MCID: SPN032
MIFTS: 44

Spindle Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Carcinoma

MalaCards integrated aliases for Spindle Cell Carcinoma:

Name: Spindle Cell Carcinoma 12 15
Sarcomatoid Carcinoma 12 17
Carcinoma, Spindle-Cell 71
Carcinoma Spindle Cell 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4015
MeSH 43 D002277
NCIt 49 C27004
SNOMED-CT 67 65692009
UMLS 71 C0205697

Summaries for Spindle Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary : Spindle Cell Carcinoma, also known as sarcomatoid carcinoma, is related to sarcomatoid transitional cell carcinoma and fibromatosis. An important gene associated with Spindle Cell Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Relaxin signaling pathway and Keratinization. The drugs Sunitinib and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Related Diseases for Spindle Cell Carcinoma

Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 794)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid transitional cell carcinoma 32.8 SYP CDH1
2 fibromatosis 31.2 VIM DES ACTC1
3 benign mesothelioma 31.0 KRT7 KRT5 CD34
4 lung giant cell carcinoma 30.9 VIM KRT18 CDH1
5 malignant fibrous histiocytoma 30.8 VIM MUC1 DES ACTC1
6 renal cell carcinoma, papillary, 1 30.8 KRT7 KRT19 HRAS CDH1 AMACR
7 intrahepatic cholangiocarcinoma 30.6 MUC1 KRT7 KRT19 CDH1
8 ureteral benign neoplasm 30.6 SYP KRT7
9 sarcomatoid mesothelioma 30.6 VIM MUC1 KRT5 DES ACTC1
10 pseudomyxoma peritonei 30.5 MUC1 KRT7 CDH1
11 adrenal cortical carcinoma 30.5 VIM SYP MUC1 CHGA ACTC1
12 adenosquamous prostate carcinoma 30.5 KRT8 AMACR
13 pancreatic ductal carcinoma 30.4 MUC1 KRT7 CDH1
14 mature teratoma 30.4 SYP KRT7 ENO2
15 collecting duct carcinoma 30.4 VIM MUC1 KRT7 KRT19 AMACR
16 spindle cell thymoma 30.4 MUC1 ENO2 DES
17 well-differentiated liposarcoma 30.4 MUC1 KRT7 CD34
18 bile duct cysts 30.3 KRT7 KRT19 HRAS
19 lung oat cell carcinoma 30.3 SYP ENO2 CHGA
20 pulmonary blastoma 30.3 SYP DES CHGA ACTC1
21 cutaneous leiomyosarcoma 30.3 VIM MUC1 DES ACTC1
22 reticulum cell sarcoma 30.3 VIM MUC1 DES ACTC1
23 ganglioneuroma 30.3 SYP ENO2 CHGA
24 fasciitis 30.3 VIM ESR1 CD34 ACTC1
25 angiosarcoma 30.2 VIM MUC1 KRT8 KRT7 CD34
26 pulmonary neuroendocrine tumor 30.2 SYP ENO2 CHGA
27 carcinosarcoma 30.2 VIM PGR MUC1 KRT7 HRAS DES
28 ameloblastic carcinoma 30.2 VIM TP63 KRT14
29 adenoma 30.2 SYP MUC1 KRT7 CHGA CDH1
30 small cell carcinoma of the bladder 30.2 SYP KRT7 ENO2 CHGA
31 sarcomatoid squamous cell skin carcinoma 30.2 KRT5 CD34
32 exophthalmos 30.2 SYP ENO2 CD34
33 mesothelioma, malignant 30.1 VIM MUC1 KRT7 KRT5 KRT19 DES
34 granular cell tumor 30.1 VIM SYP ENO2 DES
35 pseudosarcomatous fibromatosis 30.1 VIM DES CD34 ACTC1
36 rhabdoid tumor predisposition syndrome 1 30.1 VIM SYP MUC1 DES ACTC1
37 follicular adenoma 30.1 KRT19 HRAS CDH1
38 fibrous histiocytoma 30.1 VIM ENO2 DES CD34 ACTC1
39 clear cell renal cell carcinoma 30.1 VIM MUC1 KRT7 CDH1 AMACR
40 spindle cell sarcoma 30.0 VIM MUC1 KRT7 DES CD34 ACTC1
41 angiomyolipoma 30.0 VIM PGR KRT7 ESR1 DES ACTC1
42 perivascular epithelioid cell tumor 30.0 SYP PGR MUC1 DES ACTC1
43 gallbladder cancer 30.0 MUC1 KRT7 KRT19 CDH1
44 benign teratoma 30.0 SYP MUC1 KRT7 ENO2 CHGA
45 appendix adenocarcinoma 30.0 SYP KRT7 HRAS CHGA
46 squamous cell carcinoma 30.0 TP63 MUC1 KRT7 KRT19 KRT14 HRAS
47 lung benign neoplasm 30.0 SYP KRT7 HRAS ENO2 CHGA
48 squamous cell papilloma 30.0 KRT14 HRAS
49 apocrine adenocarcinoma 29.9 PGR MUC1 KRT7 KRT5 ESR1
50 pulmonary sclerosing hemangioma 29.9 SYP KRT7 ENO2 CHGA CDH1

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to Spindle Cell Carcinoma

Symptoms & Phenotypes for Spindle Cell Carcinoma

GenomeRNAi Phenotypes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.77 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.77 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.77 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.77 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.77 KRT18
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.77 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.77 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.77 KRT18
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.77 KRT18 KRT5 KRT7 KRT8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.77 KRT18
11 Reduced mammosphere formation GR00396-S 9.23 CD34 CDH1 CHGA DES HRAS KRT18

MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 ACTC1 CD34 CDH1 DES ENO2 ESR1
2 cardiovascular system MP:0005385 10.2 ACTC1 CDH1 CHGA DES ESR1 HRAS
3 growth/size/body region MP:0005378 10.18 ACTC1 AMACR CDH1 CHGA ENO2 ESR1
4 homeostasis/metabolism MP:0005376 10.17 ACTC1 AMACR CD34 CDH1 CHGA DES
5 mortality/aging MP:0010768 10.03 ACTC1 AMACR CDH1 CHGA DES ESR1
6 digestive/alimentary MP:0005381 10.01 CDH1 ESR1 HRAS KRT14 KRT19 KRT5
7 integument MP:0010771 9.91 CD34 CDH1 ESR1 HRAS KRT14 KRT19
8 neoplasm MP:0002006 9.56 CD34 CDH1 ESR1 HRAS KRT14 KRT19
9 no phenotypic analysis MP:0003012 9.17 CDH1 CHGA ESR1 HRAS KRT19 PGR

Drugs & Therapeutics for Spindle Cell Carcinoma

Drugs for Spindle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
2
Gemcitabine Approved Phase 2 95058-81-4 60750
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
5
Ipilimumab Approved Phase 2 477202-00-9
6
nivolumab Approved Phase 2 946414-94-4
7
Durvalumab Approved, Investigational Phase 2 1428935-60-7
8
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
9
Mesna Approved, Investigational Phase 2 3375-50-6 598
10
Ifosfamide Approved Phase 2 3778-73-2 3690
11
Tremelimumab Investigational Phase 2 745013-59-6
12 Protein Kinase Inhibitors Phase 2
13 Angiogenesis Inhibitors Phase 2
14 Immunologic Factors Phase 2
15 Endothelial Growth Factors Phase 2
16 Mitogens Phase 2
17 Anti-Infective Agents Phase 2
18 Antiviral Agents Phase 2
19 Immunosuppressive Agents Phase 2
20 Antimetabolites Phase 2
21 Immunoglobulins Phase 2
22 Antibodies Phase 2
23 Antibodies, Monoclonal Phase 2
24 Antineoplastic Agents, Immunological Phase 2
25
Liposomal doxorubicin Phase 2 31703
26 Alkylating Agents Phase 2
27
Isophosphamide mustard Phase 2 0
28 Anti-Bacterial Agents Phase 2
29 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell Carcinoma Unknown status NCT01219751 Phase 2 Sunitinib
2 Phase II Safety and Efficacy Study of Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Metastatic or Unresectable Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2 Capecitabine;Gemcitabine;Bevacizumab
3 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
4 A Phase II, Open-label Study to Evaluate the Efficacy and Safety of HMPL-504 in Locally Advanced/Metastatic MET-Mutation-Positive Pulmonary Sarcomatoid Carcinomas and Other Non-small Cell Lung Cancer Recruiting NCT02897479 Phase 2 Savolitinib
5 Phase II Study of Durvalumab + Tremelimumab in Pulmonary Sarcomatoid Carcinoma Active, not recruiting NCT03022500 Phase 2 durvalumab + tremelimumab
6 Phase II Study of Durvalumab ,Doxorubicin, and Ifosfamide in Pulmonary Sarcomatoid Carcinoma Not yet recruiting NCT04224337 Phase 2 Durvalumab + doxorubicin + ifosfamide
7 Integrative Analysis of Pulmonary Sarcomatoid Carcinoma (PSC) Not yet recruiting NCT04215913

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

Anatomical Context for Spindle Cell Carcinoma

MalaCards organs/tissues related to Spindle Cell Carcinoma:

40
Lung, Breast, Kidney, Skin, Prostate, Pancreas, Thyroid

Publications for Spindle Cell Carcinoma

Articles related to Spindle Cell Carcinoma:

(show top 50) (show all 1588)
# Title Authors PMID Year
1
Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. 61 54
16330937 2006
2
Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors. 54 61
15897741 2005
3
Lymphoepithelioma-like carcinoma of the renal pelvis: a case report with immunohistochemical analysis and in situ hybridization for the Epstein-Barr viral genome. 61 54
9872659 1998
4
Lymphoepithelioma-like carcinoma of the vagina: a case report with special reference to the immunophenotype of the tumor cells and tumor-infiltrating lymphoreticular cells. 61 54
8005741 1994
5
Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic NF2 Mutations. 61
32217839 2020
6
Rapid progression of mucinous tubular and spindle cell carcinoma of the kidney without sarcomatoid changes: A case report. 61
32300530 2020
7
Localized biphasic malignant peritoneal mesothelioma presenting as a rectal tumor. 61
31602554 2020
8
The treatment and outcome of a pulmonary sarcomatoid carcinoma patient infected with SARS-CoV-2. 61
32563532 2020
9
MYC Expression has Limited Utility in the Distinction of Undifferentiated Radiation-associated Sarcomas from Sporadic Sarcomas and Sarcomatoid Carcinoma. 61
32506510 2020
10
Lung nuclear protein in testis carcinoma in an elderly Korean woman: A case report with cytohistological analysis. 61
32319714 2020
11
Sarcomatoid variant of squamous carcinoma in recurrent and second primary tumors of the oral cavity. 61
32506553 2020
12
Characteristics of penile cancer in Japan: An analysis of nationwide hospital-based cancer registry data. 61
32307745 2020
13
Primary tumor standardized uptake value (SUVmax) measured on 18F-FDG PET/CT and mixed NSCLC components predict survival in surgical-resected combined small-cell lung cancer. 61
32494919 2020
14
Clinical, pathological and treatment factors associated with the survival of patients with pulmonary sarcomatoid carcinoma. 61
32382345 2020
15
Rare case of sarcomatoid carcinoma of the prostate with metastatic skin tumor manifestation. 61
32515114 2020
16
First-line albumin-bound paclitaxel/carboplatin plus apatinib in advanced pulmonary sarcomatoid carcinoma: A case series and review of the literature. 61
32502055 2020
17
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective. 61
32476435 2020
18
Morphological features useful in the differential diagnosis between undifferentiated carcinoma and gastrointestinal stromal tumor. 61
32388398 2020
19
Sarcoma metastasis to the pancreas: experience at a single institution. 61
32311873 2020
20
Sarcomatoid carcinoma of the pancreas with rare long-term survival: a case report. 61
32450860 2020
21
Vertical One-and-a-Half Syndrome Due to Metastatic Spindle Cell Carcinoma of the Lung. 61
32450926 2020
22
18 F-FDG PET/CT imaging of small intestinal metastasis from pulmonary sarcomatoid carcinoma: Brief report and review of the literature. 61
32410331 2020
23
Evidence of NTRK1 Fusion as Resistance Mechanism to EGFR TKI in EGFR+ NSCLC: Results From a Large-Scale Survey of NTRK1 Fusions in Chinese Patients With Lung Cancer. 61
31761448 2020
24
Pancreatic sarcomatoid carcinoma: CT, MRI, and 18F-FDG PET/CT features. 61
32044096 2020
25
Resection of pulmonary sarcomatoid carcinoma metastasized to the right ventricle. 61
32293053 2020
26
Efficacy of Immune Checkpoint Inhibitors in Lung Sarcomatoid Carcinoma. 61
31991225 2020
27
Multiple carcinosarcomas of the esophagus with adeno-carcinomatous components: A case report. 61
32536778 2020
28
Considering the Better Donor-side in Reconstruction of Composite Radius After Resection of Spindle Cell Sarcoma Using Free Fibular Osteocutaneous Flap: A Case Report. 61
32494219 2020
29
Stereotactic body radiation therapy (SBRT) in the management of pulmonary spindle cell carcinoma. 61
32327465 2020
30
Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway. 61
31069711 2020
31
A diagnostically challenging spindle cell carcinoma of the neck: Treatment with Mohs micrographic surgery and clinical course. 61
32258305 2020
32
Frequent Mutations of POT1 Distinguish Pulmonary Sarcomatoid Carcinoma From Other Lung Cancer Histologies. 61
32414627 2020
33
Pulmonary Sarcomatoid Carcinoma: Experience from SEER Database and Shanghai Pulmonary Hospital. 61
32268141 2020
34
Morphologic and genetic heterogeneity in breast fibroepithelial lesions-a comprehensive mapping study. 61
32322022 2020
35
Application of laser capture microdissection and polymerase chain reaction in the diagnosis of Trichoderma longibrachiatum infection: a promising diagnostic tool for 'fungal contaminants' infection. 61
31127839 2020
36
A case treated with Crizotinib after secondary MET amplification of A double Rare L747S and G719S EGFR mutation Pulmonary Sarcomatoid Carcinoma. 61
32122695 2020
37
Favorable response to pembrolizumab after durvalumab failure in a stage III sarcomatoid carcinoma of the lung: a case report. 61
32245391 2020
38
Carcinosarcoma Arising from Inverted Papilloma in a Patient with History of Radiotherapy for Sinonasal Squamous Cell Carcinoma. 61
32200390 2020
39
Primary malignant pericardial tumour in Lynch syndrome. 61
32143595 2020
40
Paraneoplastic Hyperleukocytosis Mimicking Hematologic Malignancy Revealing a Localized Lung Cancer. 61
31408646 2020
41
Nivolumab for the Treatment of Patients with Metastatic Non-Clear Cell Renal Cell Carcinoma (nccRCC): A Single-Institutional Experience and Literature Meta-Analysis. 61
32162795 2020
42
Clinical and pathological characteristics of bladder cancer in post brachytherapy patients. 61
31982182 2020
43
Infarct-Like Spindle Cell Carcinoma of the Lung: Clinicopathologic, Immunohistochemical, and Molecular Analysis of 4 Cases. 61
32188318 2020
44
Rapid Sarcomatoid Transformation of Lung Squamous Cell Carcinoma After Neoadjuvant Therapy: A Case Report. 61
32132066 2020
45
Relationship Between Programmed Death Receptor-Ligand 1 Expression and Response to Checkpoint Inhibitor Immunotherapy in Pulmonary Sarcomatoid Carcinoma: A Pooled Analysis. 61
32265109 2020
46
Molecular Profiling of the Metaplastic Spindle Cell Carcinoma of the Breast Reveals Potentially Targetable Biomarkers. 61
32197944 2020
47
A case of high-grade mucinous tubular and spindle cell carcinoma. 61
32104563 2020
48
Expression Profiling of Driver Genes in Female Never-smokers With Non-adenocarcinoma Non-small-cell Lung Cancer in China. 61
32139332 2020
49
Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx. 61
31852360 2020
50
Squamous cell carcinoma with sarcomatoid differentiation or carcinosarcoma of the uterine cervix associated with HPV33 infection: report of a rare case. 61
32035484 2020

Variations for Spindle Cell Carcinoma

Expression for Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for Spindle Cell Carcinoma

Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 PGR KRT19 KRT18 KRT14 HRAS ESR1
2
Show member pathways
12.09 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
3 11.81 VIM MUC1 KRT8 KRT7 KRT5 KRT19
4
Show member pathways
11.59 VIM KRT8 KRT7 KRT5 KRT19 KRT18
5 11.4 VIM DES ACTC1
6 11.04 KRT8 KRT19 ESR1

GO Terms for Spindle Cell Carcinoma

Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.25 VIM TP63 PGR MUC1 KRT8 KRT7
2 cytosol GO:0005829 10.21 VIM PGR KRT8 KRT7 KRT5 KRT19
3 extracellular exosome GO:0070062 9.93 VIM MUC1 KRT8 KRT7 KRT5 KRT19
4 perinuclear region of cytoplasm GO:0048471 9.91 SYP KRT18 HRAS CHGA CDH1 CD34
5 keratin filament GO:0045095 9.65 KRT8 KRT7 KRT5 KRT18 KRT14
6 intermediate filament cytoskeleton GO:0045111 9.58 VIM KRT8 DES
7 cell periphery GO:0071944 9.35 KRT8 KRT19 KRT18 KRT14 CD34
8 intermediate filament GO:0005882 9.23 VIM KRT8 KRT7 KRT5 KRT19 KRT18

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemidesmosome assembly GO:0031581 9.43 KRT5 KRT14
2 keratinization GO:0031424 9.43 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
3 epithelial cell development GO:0002064 9.4 TP63 ESR1
4 hepatocyte apoptotic process GO:0097284 9.37 KRT8 KRT18
5 muscle filament sliding GO:0030049 9.33 VIM DES ACTC1
6 paracrine signaling GO:0038001 9.32 PGR CD34
7 cell differentiation involved in embryonic placenta development GO:0060706 9.26 KRT8 KRT19
8 cornification GO:0070268 9.1 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14

Molecular functions related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.26 VIM KRT8 KRT5 KRT18
2 keratin filament binding GO:1990254 9.16 VIM KRT14
3 structural constituent of cytoskeleton GO:0005200 9.02 VIM KRT5 KRT19 KRT14 DES

Sources for Spindle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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