SCH
MCID: SPN012
MIFTS: 31

Spindle Cell Hemangioma (SCH)

Categories: Cancer diseases, Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Spindle Cell Hemangioma

MalaCards integrated aliases for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 12 58 15 70
Sch 12 73 17
Spindle Cell Hemangioendothelioma 58

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 12 DOID:496
NCIt 50 C4754
SNOMED-CT 67 128769003
ICD10 via Orphanet 33 D18.0
UMLS via Orphanet 71 C1304508
Orphanet 58 ORPHA210584
UMLS 70 C1304508

Summaries for Spindle Cell Hemangioma

MalaCards based summary : Spindle Cell Hemangioma, also known as sch, is related to hemangioma and enchondroma. An important gene associated with Spindle Cell Hemangioma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), and among its related pathways/superpathways is Cytosine methylation. Affiliated tissues include spleen, spinal cord and endothelial.

Wikipedia : 73 Hemangioendotheliomas are a family of vascular neoplasms of intermediate... more...

Related Diseases for Spindle Cell Hemangioma

Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
# Related Disease Score Top Affiliating Genes
1 hemangioma 31.0 PROX1 IDH2 IDH1 GNA14
2 enchondroma 30.4 IDH2 IDH1
3 kaposiform hemangioendothelioma 30.3 PROX1 GNA14
4 multiple enchondromatosis, maffucci type 30.1 IDH2 IDH1
5 hemangioendothelioma 11.3
6 henoch-schoenlein purpura 11.0
7 adult brain stem glioma 10.3 IDH2 IDH1
8 brain stem glioma 10.3 IDH2 IDH1
9 cytogenetically normal acute myeloid leukemia 10.3 IDH2 IDH1
10 intracranial chondrosarcoma 10.3 IDH2 IDH1
11 periosteal chondrosarcoma 10.3 IDH2 IDH1
12 adult oligodendroglioma 10.3 IDH2 IDH1
13 childhood oligodendroglioma 10.3 IDH2 IDH1
14 juxtacortical chondroma 10.3 IDH2 IDH1
15 gemistocytic astrocytoma 10.3 IDH2 IDH1
16 adult astrocytic tumour 10.3 IDH2 IDH1
17 hepatitis c virus 10.3
18 mixed oligodendroglioma-astrocytoma 10.2 IDH2 IDH1
19 tick-borne encephalitis 10.2
20 encephalitis 10.2
21 mixed glioma 10.2 IDH2 IDH1
22 epithelioid hemangioendothelioma 10.2
23 chondroblastic osteosarcoma 10.2 IDH2 IDH1
24 bronchitis 10.2
25 haemophilus influenzae 10.2
26 hepatitis c 10.2
27 low grade glioma 10.2 IDH2 IDH1
28 lipomatosis, multiple 10.2
29 pleomorphic lipoma 10.2
30 immune deficiency disease 10.1
31 human immunodeficiency virus type 1 10.1
32 hypothyroidism 10.1
33 candidiasis 10.1
34 kaposi sarcoma 10.1
35 wilms tumor 1 10.1
36 angiosarcoma 10.1
37 aspergillosis 10.1
38 osteogenic sarcoma 10.1
39 allergic rhinitis 10.1
40 exercise-induced bronchoconstriction 10.1
41 neutropenia 10.1
42 blastomycosis 10.1
43 hypereosinophilic syndrome 10.1
44 huntington disease 10.0
45 cryptococcosis 10.0
46 coccidioidomycosis 10.0
47 purpura 10.0
48 rhinitis 10.0
49 meningitis 10.0
50 human herpesvirus 8 10.0

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to Spindle Cell Hemangioma

Symptoms & Phenotypes for Spindle Cell Hemangioma

Drugs & Therapeutics for Spindle Cell Hemangioma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

Anatomical Context for Spindle Cell Hemangioma

MalaCards organs/tissues related to Spindle Cell Hemangioma:

40
Spleen, Spinal Cord, Endothelial, Lymph Node, Pancreas, Thyroid, Skin

Publications for Spindle Cell Hemangioma

Articles related to Spindle Cell Hemangioma:

(show top 50) (show all 124)
# Title Authors PMID Year
1
Spindle cell hemangioma of nasal passage and ethmoidal sinus in a 4-month old infant. 61
33458988 2021
2
Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report. 61
33546375 2021
3
Spindle cell hemangioma in the infratemporal fossa: A unique case report. 61
33310467 2021
4
Concurrent Spindle Cell Hemangioma and Schwannoma of the Jugular Foramina. 61
32810020 2020
5
Composite Hemangioendothelioma With Neuroendocrine Marker Expression: Report of a "Paraganglioma-Like" Paravertebral Case. 61
32418470 2020
6
Intramuscular composite hemangioendothelioma: case report of an unusual tumor in an unusual location. 61
32661479 2020
7
Successful treatment of spindle cell hemangiomas in a patient with Maffucci syndrome and review of literatures. 61
30977938 2019
8
Multiple spindle cell hemangiomas in both lungs: a rare case report and review of the literature. 61
31046794 2019
9
Spindle cell hemangioma of the spleen: A case report. 61
30817572 2019
10
The Molecular Diagnostics of Vascular Neoplasms. 61
30709447 2019
11
Spindle Cell Hemangioma in the Mucosa of the Upper Lip: A Case Report and Review of the Literature. 61
29780644 2018
12
Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia. 61
29445571 2018
13
Mutational analysis using Sanger and next generation sequencing in sporadic spindle cell hemangiomas: A study of 19 cases. 61
28845532 2017
14
Spindle Cell Hemangioma of the Midfoot: A Case Report. 61
29242801 2017
15
[Spindle cell hemangioma: a clinicopathologic analysis of 3 cases]. 61
28591992 2017
16
Histopathology of Spindle Cell Vascular Tumors. 61
28477885 2017
17
Percutaneous cryotherapy for pain treatment of spindle cell hemangioendothelioma of the hand. 61
28161304 2017
18
Spindle cell haemangioma of the tongue. 61
27445035 2016
19
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. 61
26945705 2016
20
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions. 61
27318413 2016
21
Intramedullary spindle cell hemangioma: case report. 61
27058496 2016
22
Multifocal spindle cell hemangioma: Report of two cases. 61
26728826 2016
23
[Spindle-shaped hemangioma: an unusual location]. 61
27642429 2016
24
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. 61
26980977 2015
25
Spindle Cell Hemangioendothelioma: Rare Clinical Entity. 61
26538705 2015
26
Spindle cell hemangioma of thyroid. 61
26905134 2015
27
Angiosarcoma of the pericardium: a case report. 61
26722576 2015
28
Spindle cell hemangioendothelioma of the sacrum: case report. 61
24785972 2014
29
A spindle cell hemangioendothelioma on the head resembling an arteriovenous malformation. 61
24978448 2014
30
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. 61
24673328 2014
31
Periosteal spindle cell hemangioma of the fibula: a case report. 61
23525489 2013
32
Maffucci syndrome with the spindle cell hemangiomas in the mucosa of the lower lip: a rare case report and literature review. 61
23506121 2013
33
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. 61
23485734 2013
34
Hemangioendothelioma. 61
23327728 2013
35
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. 61
22534243 2012
36
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. 61
22927295 2012
37
Spindle cell hemangioma reoccurrence in the hand: case report. 61
23730241 2012
38
Prox1 transcription factor as a marker for vascular tumors-evaluation of 314 vascular endothelial and 1086 nonvascular tumors. 61
22067331 2012
39
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. 61
22057234 2011
40
Wilms tumor 1 expression in vascular neoplasms and vascular malformations. 61
21697701 2011
41
[Vascular tumors and pseudo-tumors. Spindle-cell hemangioma]. 61
21839351 2011
42
Hemangioma related to Maffucci syndrome in a man: a case report. 61
21689466 2011
43
Spindle cell hemangioendothelioma of the temporal muscle resected with zygomatic osteotomy: a case report of an unusual intramuscular lesion mimicking sarcoma. 61
22606579 2011
44
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. 61
20860749 2010
45
Reactive proliferation of endothelial cells and pericytes associated with arteriovenous malformation. 61
20507408 2010
46
Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity. 61
20196675 2010
47
[Spindle cell hemangioma in frontal bone: report of a case]. 61
20388381 2010
48
Do intracranial neoplasms differ in Ollier disease and maffucci syndrome? An in-depth analysis of the literature. 61
19934970 2009
49
Composite cutaneous hemangioendothelioma on the back. 61
18496428 2008
50
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. 61
17656123 2008

Variations for Spindle Cell Hemangioma

Expression for Spindle Cell Hemangioma

Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for Spindle Cell Hemangioma

Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
9.74 IDH2 IDH1

GO Terms for Spindle Cell Hemangioma

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 2-oxoglutarate metabolic process GO:0006103 9.26 IDH2 IDH1
2 NADP metabolic process GO:0006739 9.16 IDH2 IDH1
3 isocitrate metabolic process GO:0006102 8.96 IDH2 IDH1
4 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenyl-nucleotide exchange factor activity GO:0000774 9.16 BAG2 BAG1
2 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
3 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Spindle Cell Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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