SCH
MCID: SPN012
MIFTS: 36

Spindle Cell Hemangioma (SCH)

Categories: Cancer diseases, Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Spindle Cell Hemangioma

MalaCards integrated aliases for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 12 59 15 73
Sch 12 76
Spindle Cell Hemangioendothelioma 59

Classifications:



External Ids:

Disease Ontology 12 DOID:496
NCIt 50 C4754
Orphanet 59 ORPHA210584
UMLS via Orphanet 74 C1304508
ICD10 via Orphanet 34 D18.0
UMLS 73 C1304508

Summaries for Spindle Cell Hemangioma

MalaCards based summary : Spindle Cell Hemangioma, also known as sch, is related to multiple enchondromatosis, maffucci type and enchondroma. An important gene associated with Spindle Cell Hemangioma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic), and among its related pathways/superpathways are Peroxisome and Cytosine methylation. The drugs Abraxane and Actiq have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes.

Wikipedia : 76 Jean Baptiste Point du Sable (before 1750 ? 1818) is honored as the first permanent non-Native-American... more...

Related Diseases for Spindle Cell Hemangioma

Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 multiple enchondromatosis, maffucci type 30.3 IDH1 IDH2
2 enchondroma 30.1 IDH1 IDH2
3 enchondromatosis, multiple, ollier type 30.0 IDH1 IDH2
4 hemangioendothelioma 11.6
5 henoch-schoenlein purpura 11.1
6 hemangioma 10.6
7 hepatitis c virus 10.3
8 hepatitis 10.3
9 hepatitis c 10.3
10 interval angle-closure glaucoma 10.2 IDH1 IDH2
11 adult oligodendroglioma 10.2 IDH1 IDH2
12 intracranial chondrosarcoma 10.2 IDH1 IDH2
13 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
14 chondroblastic osteosarcoma 10.2 IDH1 IDH2
15 intraductal papilloma 10.2 IDH1 IDH2
16 pilocytic astrocytoma of cerebellum 10.2 IDH1 IDH2
17 periosteal chondrosarcoma 10.2 IDH1 IDH2
18 glioma susceptibility 1 10.2 IDH1 IDH2
19 adult astrocytic tumour 10.2 IDH1 IDH2
20 fibrillary astrocytoma 10.2 IDH1 IDH2
21 diffuse infiltrative lymphocytosis syndrome 10.1 IDH1 IDH2
22 drug-induced mental disorder 10.1 IDH1 IDH2
23 drug psychosis 10.1 IDH1 IDH2
24 undifferentiated pleomorphic sarcoma 10.1 IDH1 IDH2
25 2-hydroxyglutaric aciduria 10.1 IDH1 IDH2
26 schizophrenia 10.1
27 hypothyroidism 10.1
28 d-2-hydroxyglutaric aciduria 1 10.1 IDH1 IDH2
29 bile duct adenocarcinoma 10.1 IDH1 IDH2
30 brain stem glioma 10.1 IDH1 IDH2
31 noonan syndrome 3 10.1
32 depression 10.1
33 supratentorial cancer 10.1 IDH1 IDH2
34 cerebrum cancer 10.0 IDH1 IDH2
35 blastomycosis 10.0
36 ischemia 10.0
37 meningitis 10.0
38 central nervous system cancer 10.0 IDH1 IDH2
39 arteriovenous malformation 10.0
40 colorectal cancer 10.0
41 hypertension, essential 10.0
42 allergic rhinitis 10.0
43 leukemia 10.0
44 intrahepatic cholangiocarcinoma 9.9 IDH1 IDH2
45 lymphedema 9.9
46 epithelioid hemangioendothelioma 9.9
47 ovarian cancer 9.9
48 human immunodeficiency virus type 1 9.9
49 gastric cancer 9.9
50 aspergillosis 9.9

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to Spindle Cell Hemangioma

Symptoms & Phenotypes for Spindle Cell Hemangioma

Drugs & Therapeutics for Spindle Cell Hemangioma

FDA approved drugs:

(show all 50)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Abraxane 18 49 PACLITAXEL Celgene October 2012
2
Actiq 18 FENTANYL (citrate) Anesta Corporation November 1998
3
Akynzeo 18 49 NETUPITANT AND PALONOSETRON (hydrochloride) Helsinn October 2014
4
Aromasin Tablets 18 49 EXEMESTANE Pharmacia & Upjohn October 21. 1999
5
Arranon 18 49 NELARABINE GlaxoSmithKline October 2005
6
Arzerra 18 49 OFATUMUMAB GlaxoSmithKline October 2009
7
Bexxar 18 49 TOSITUMOMAB; IODINE I 131 TOSITUMOMAB Corixa June 2003
8
Blincyto 18 49 BLINATUMOMAB Amgen December 2014
9
Busulfex 18 49 BUSULFAN Orphan Medical February 1999
10
Cervarix 18 49 Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant GlaxoSmithKline October 2009
11
Erivedge 18 49 VISMODEGIB Genentech January 2012
12
Erwinaze 18 49 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
13
Evista 18 49 RALOXIFENE HYDROCHLORIDE Eli Lilly September 2007
14
Farydak 18 49 PANOBINOSTAT LACTATE Novartis February 2015
15
Folotyn 18 49 PRALATREXATE Allos Therapeutics September 2009
16
Herceptin 18 49 TRASTUZUMAB Genentech October 1998
17
Istodax 18 49 ROMIDEPSIN Gloucester Pharmaceuticals November 2009
18
Ixempra 18 49 IXABEPILONE Bristol-Myers Squibb October 2007
19
Kytril 18 GRANISETRON HYDROCHLORIDE Roche/SmithKline Beecham June 2001/ November 1997
20
Leukine 18 SARGRAMOSTIM Immunex on November 24, 1995/ November 1996
21
Neulasta 18 PEGFILGRASTIM Amgen January 2002
22
Neumega 18 OPRELVEKIN Genetics Institute November 1997
23
Nolvadex 18 49 TAMOXIFEN CITRATE AstraZeneca October 1998
24
Picato gel 18 INGENOL MEBUTATE LEO Pharma January 2012
25
Self-examination breast pad 18 Inventive Products on December 22, 1995
26
Sensipar 18 CINACALCET HYDROCHLORIDE Amgen March 2004
27
Sutent 18 49 SUNITINIB MALATE Pfizer May 2011/ January 2006
28
Synribo 18 49 OMACETAXINE MEPESUCCINATE Teva Pharmaceutical October 2012
29
Tafinlar 18 49 DABRAFENIB MESYLATE GlaxoSmithKline May 2013
30
UroXatral 18 ALFUZOSIN HYDROCHLORIDE Sanofi-aventis June 2003
31
Xalkori 18 49 CRIZOTINIB Pfizer August of 2011
32
Yervoy 18 49 IPILIMUMAB Bristol-Myers Squibb March 2011
33
Zelboraf 18 49 VEMURAFENIB Roche August of 2011
34
Adempas 18 RIOCIGUAT Bayer Healthcare Pharmaceuticals October 2013
35
Alvesco 18 CICLESONIDE Nycomed January 2008
36
Azmacort 18 TRIAMCINOLONE ACETONIDE Rhone Poulenc Rorer November 1996
37
Breathe Right 18 CNS June 1996
38
Cayston 18 AZTREONAM Gilead February 2010
39
Clarinex 18 DESLORATADINE Schering-Plough February 2002
40
Daliresp 18 ROFLUMILAST Forest Pharmaceuticals February 2011
41
Dulera 18 FORMOTEROL FUMARATE; MOMETASONE FUROATE Merck June 2010
42
Letairis 18 AMBRISENTAN Gilead June 2007
43
Nasacort AQ Nasal Spray 18 TRIAMCINOLONE ACETONIDE Phone-Poulenc Rorer October 1997
44
Qvar 18 BECLOMETHASONE DIPROPIONATE Ivax May 2002
45
Sirturo 18 BEDAQUILINE FUMARATE Janssen Therapeutics December 2012
46
Tagrisso 18 OSIMERTINIB MESYLATE AstraZeneca November 2015
47
Tri-Nasal Spray 18 Muro Pharmaceutical February 2000
48
Tygacil 18 TIGECYCLINE Wyeth 2005
49
Tyvaso 18 TREPROSTINIL United Therapeutics July 2009
50
Zosyn 18 PIPERACILLIN SODIUM; TAZOBACTAM SODIUM Wyeth May 1996

Search Clinical Trials , NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

Anatomical Context for Spindle Cell Hemangioma

MalaCards organs/tissues related to Spindle Cell Hemangioma:

41
Brain, Cortex, Testes, Prefrontal Cortex, Retina, Lung, Bone

Publications for Spindle Cell Hemangioma

Articles related to Spindle Cell Hemangioma:

(show top 50) (show all 942)
# Title Authors Year
1
Expression and Clinical Significance of Serum 25-OH-D in pregnant women with SCH (Subclinical Hypothyroidism) and GDM (Gestational Diabetes Mellitus). ( 30344591 )
2018
2
Spindle Cell Hemangioma in the Mucosa of the Upper Lip: A Case Report and Review of the Literature. ( 29780644 )
2018
3
MELD-SCH: A megastudy of lexical decision in simplified Chinese. ( 28779457 )
2018
4
Toxic effects of Solanum xanthocarpum Sch &Wendle against Helicoverpa armigera (Hub.), Culex quinquefasciatus (Say.) and Eisenia fetida (Savigny, 1826). ( 29143256 )
2018
5
Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer. ( 29157102 )
2018
6
Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity. ( 29382040 )
2018
7
Synthesis of 3 H, 13 C2 , 2 H414 C-SCH 430765 and 35 S-SCH 500946, potent and selective inhibitors of the NPY5 receptor. ( 29493011 )
2018
8
Chemical diversity of the essential oils of twenty populations of Tanacetum polycephalum Sch. Bip. from Iran. ( 29768020 )
2018
9
CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712. ( 29784728 )
2018
10
New Poisson-Sch type inequalities and their applications in quantum calculus. ( 30137887 )
2018
11
SCH-GAN: Semi-Supervised Cross-Modal Hashing by Generative Adversarial Network. ( 30273169 )
2018
12
Main Allelochemicals from the Rhizosphere Soil of Saussurea lappa (Decne.) Sch. Bip. and Their Effects on Plants' Antioxidase Systems. ( 30274332 )
2018
13
Pharmacological study of anti-inflammatory activity of aqueous extracts of Mikania glomerata (Spreng.) and Mikania laevigata (Sch. Bip. ex Baker). ( 30415057 )
2018
14
Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine D1 receptor antagonist SCH-23390 or the serotonin 5-HT2C agonist lorcaserin. ( 30419272 )
2018
15
Endophytic Fungus Isolated From Achyrocline satureioides Exhibits Selective Antiglioma Activity-The Role of Sch-642305. ( 30420941 )
2018
16
Characterization of polycyclic aromatic hydrocarbons (PAHs) in small craft harbour (SCH) sediments in Nova Scotia, Canada. ( 30503437 )
2018
17
Spindle Cell Hemangioma of the Midfoot: A Case Report. ( 29242801 )
2017
18
Effect of Thyroxin Treatment on Carotid Intima-Media Thickness (CIMT) Reduction in Patients with Subclinical Hypothyroidism (SCH): a Meta-Analysis of Clinical Trials. ( 28566564 )
2017
19
A simple and rapid UHPLC-MS/MS method for the quantitation of the dual aurora kinase A/B inhibitor SCH-1473759 in murine plasma. ( 27768921 )
2017
20
Structural Determination of (-)-SCH 64874 and Hirsutellomycin by Semisynthesis. ( 27966974 )
2017
21
SEM studies on acanthocephalan parasite, Echinorhynchus veli infecting the fish Synaptura orientalis (Bl & Sch, 1801). ( 28316390 )
2017
22
Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: A test-retest analysis using [11C]SCH-23390. ( 28419852 )
2017
23
Further result on Dirichlet-Sch type inequality and its application. ( 28546734 )
2017
24
Phytotoxicity Study on Bidens sulphurea Sch. Bip. as a Preliminary Approach for Weed Control. ( 28605187 )
2017
25
EPICOG-SCH: A brief battery to screen cognitive impact of schizophrenia in stable outpatients. ( 28740826 )
2017
26
Selective A2A receptor antagonist SCH 58261 modulates striatal oxidative stress and alleviates toxicity induced by 3-Nitropropionic acid in male Wistar rats. ( 28795281 )
2017
27
An Assessment of Five (PANSS, SAPS, SANS, NSA-16, CGI-SCH) commonly used Symptoms Rating Scales in Schizophrenia and Comparison to Newer Scales (CAINS, BNSS). ( 29430333 )
2017
28
Multifocal spindle cell hemangioma: Report of two cases. ( 26728826 )
2016
29
Intramedullary spindle cell hemangioma: case report. ( 27058496 )
2016
30
A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma. ( 27362300 )
2016
31
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. ( 26945705 )
2016
32
Differential effects of co-administration of oxotremorine with SCH 23390 on impulsive choice in high-impulsive rats and low-impulsive rats. ( 26772787 )
2016
33
Identification of the Fluvirucin B2 (Sch 38518) Biosynthetic Gene Cluster from Actinomadura fulva subsp. indica ATCC 53714: substrate Specificity of the β-Amino Acid Selective Adenylating Enzyme FlvN. ( 26818633 )
2016
34
Saussurea tridactyla Sch. Bip.-derived polysaccharides and flavones reduce oxidative damage in ultraviolet B-irradiated HaCaT cells via a p38MAPK-independent mechanism. ( 26855564 )
2016
35
Synthesis of (3) H, (2) H4 and (14) C-SCH 417690 (Vicriviroc). ( 26991320 )
2016
36
Systemic injection of the DAD1 antagonist SCH 23390 reduces saccharin seeking in rats. ( 27179937 )
2016
37
Total Synthesis of (+)-SCH 351448: Efficiency via Chemoselectivity and Redox-Economy Powered by Metal Catalysis. ( 27337561 )
2016
38
Hydroalcoholic extract and pure compounds from Senecio nutans Sch. Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms. ( 27392595 )
2016
39
Inhibitory effects of Saussurea involucrata (Kar. et Kir.) Sch. -Bip. on adjuvant arthritis in rats. ( 27616030 )
2016
40
Regio- and Stereoselective Homologation of 1,2-Bis(Boronic Esters): Stereocontrolled Synthesis of 1,3-Diols and Sch 725674. ( 27781356 )
2016
41
Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors. ( 27836402 )
2016
42
SCH 79797, a selective PAR1 antagonist, protects against ischemia/reperfusion-induced arrhythmias in the rat hearts. ( 27906419 )
2016
43
Chemical composition of the essential oil from Pulicaria vulgaris var. graeca (Sch.-Bip.) Fiori (Asteraceae) growing wild in Sicily and its antimicrobial activity. ( 26180932 )
2016
44
Timing of SCH 23390 administration influences extinction of conditioned hyperactivity in mice. ( 26292185 )
2016
45
First Total Synthesis of Gliomasolide C and Formal Total Synthesis of Sch-725674. ( 26633579 )
2016
46
Hypotensive and antihypertensive effects of a hydroalcoholic extract from Senecio nutans Sch. Bip. (Compositae) in mice: Chronotropic and negative inotropic effect, a nifedipine-like action. ( 26724424 )
2016
47
A Pot-Economical Approach to the Total Synthesis of Sch-725674. ( 26760683 )
2016
48
Spindle cell hemangioma of thyroid. ( 26905134 )
2015
49
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. ( 26980977 )
2015
50
An enantioselective total synthesis of Sch-725674. ( 25379975 )
2015

Variations for Spindle Cell Hemangioma

Expression for Spindle Cell Hemangioma

Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for Spindle Cell Hemangioma

Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 IDH1 IDH2
2
Show member pathways
9.74 IDH1 IDH2

GO Terms for Spindle Cell Hemangioma

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.32 IDH1 IDH2
2 2-oxoglutarate metabolic process GO:0006103 9.26 IDH1 IDH2
3 NADP metabolic process GO:0006739 9.16 IDH1 IDH2
4 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
5 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.26 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Spindle Cell Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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