MCID: SPN012
MIFTS: 30

Spindle Cell Hemangioma

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Spindle Cell Hemangioma

MalaCards integrated aliases for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 12 59 15 73
Sch 12 76
Spindle Cell Hemangioendothelioma 59

Classifications:



External Ids:

Disease Ontology 12 DOID:496
NCIt 50 C4754
Orphanet 59 ORPHA210584
UMLS via Orphanet 74 C1304508
ICD10 via Orphanet 34 D18.0
UMLS 73 C1304508

Summaries for Spindle Cell Hemangioma

MalaCards based summary : Spindle Cell Hemangioma, also known as sch, is related to multiple enchondromatosis, maffucci type and enchondroma. An important gene associated with Spindle Cell Hemangioma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic), and among its related pathways/superpathways are Peroxisome and Cytosine methylation. Affiliated tissues include cervix, thyroid and bone.

Wikipedia : 76 Hemangioendotheliomas are a family of vascular neoplasms of intermediate... more...

Related Diseases for Spindle Cell Hemangioma

Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 multiple enchondromatosis, maffucci type 30.7 IDH1 IDH2
2 enchondroma 30.5 IDH1 IDH2
3 enchondromatosis, multiple, ollier type 30.0 IDH1 IDH2
4 hemangioendothelioma 11.4
5 interval angle-closure glaucoma 10.6 IDH1 IDH2
6 adult oligodendroglioma 10.6 IDH1 IDH2
7 intracranial chondrosarcoma 10.6 IDH1 IDH2
8 cytogenetically normal acute myeloid leukemia 10.6 IDH1 IDH2
9 chondroblastic osteosarcoma 10.6 IDH1 IDH2
10 intraductal papilloma 10.5 IDH1 IDH2
11 pilocytic astrocytoma of cerebellum 10.5 IDH1 IDH2
12 glioma susceptibility 1 10.5 IDH1 IDH2
13 periosteal chondrosarcoma 10.5 IDH1 IDH2
14 adult astrocytic tumour 10.5 IDH1 IDH2
15 fibrillary astrocytoma 10.5 IDH1 IDH2
16 hemangioma 10.5
17 undifferentiated pleomorphic sarcoma 10.5 IDH1 IDH2
18 drug-induced mental disorder 10.5 IDH1 IDH2
19 drug psychosis 10.4 IDH1 IDH2
20 diffuse infiltrative lymphocytosis syndrome 10.4 IDH1 IDH2
21 2-hydroxyglutaric aciduria 10.4 IDH1 IDH2
22 brain stem glioma 10.4 IDH1 IDH2
23 breast papillary carcinoma 10.3 IDH1 IDH2
24 d-2-hydroxyglutaric aciduria 1 10.3 IDH1 IDH2
25 bile duct adenocarcinoma 10.1 IDH1 IDH2
26 intrahepatic cholangiocarcinoma 10.0 IDH1 IDH2
27 blastomycosis 10.0
28 hepatitis c virus 9.9
29 hepatitis 9.9
30 hepatitis c 9.9
31 colorectal cancer 9.8
32 purpura 9.8
33 neuronitis 9.8
34 oligodendroglioma 9.8 IDH1 IDH2
35 lymphedema 9.8
36 thyroiditis 9.8
37 periostitis 9.8
38 epithelioid hemangioendothelioma 9.8
39 hypertension, essential 9.7
40 insulin-like growth factor i 9.7
41 ventricular fibrillation, paroxysmal familial, 1 9.7
42 gastric cancer 9.7
43 malignant glioma 9.7
44 fusariosis 9.7
45 congenital hypothyroidism 9.7
46 prostatic hypertrophy 9.7
47 tinea cruris 9.7
48 tinea corporis 9.7
49 paracoccidioidomycosis 9.7
50 coccidioidomycosis 9.7

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to Spindle Cell Hemangioma

Symptoms & Phenotypes for Spindle Cell Hemangioma

Drugs & Therapeutics for Spindle Cell Hemangioma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

Anatomical Context for Spindle Cell Hemangioma

MalaCards organs/tissues related to Spindle Cell Hemangioma:

41
Cervix, Thyroid, Bone

Publications for Spindle Cell Hemangioma

Articles related to Spindle Cell Hemangioma:

(show all 24)
# Title Authors Year
1
Spindle Cell Hemangioma in the Mucosa of the Upper Lip: A Case Report and Review of the Literature. ( 29780644 )
2018
2
Spindle Cell Hemangioma of the Midfoot: A Case Report. ( 29242801 )
2017
3
Multifocal spindle cell hemangioma: Report of two cases. ( 26728826 )
2016
4
Intramedullary spindle cell hemangioma: case report. ( 27058496 )
2016
5
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. ( 26945705 )
2016
6
Spindle cell hemangioma of thyroid. ( 26905134 )
2015
7
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. ( 26980977 )
2015
8
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. ( 24673328 )
2014
9
Periosteal spindle cell hemangioma of the fibula: a case report. ( 23525489 )
2013
10
Maffucci syndrome with the spindle cell hemangiomas in the mucosa of the lower lip: a rare case report and literature review. ( 23506121 )
2013
11
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. ( 23485734 )
2013
12
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. ( 22534243 )
2012
13
Spindle cell hemangioma reoccurrence in the hand: case report. ( 23730241 )
2012
14
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. ( 22927295 )
2012
15
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. ( 22057234 )
2011
16
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. ( 20860749 )
2010
17
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. ( 17656123 )
2008
18
Spindle cell hemangioma: report of a case presenting in the oral cavity. ( 17880587 )
2007
19
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. ( 16778491 )
2006
20
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? ( 16630186 )
2006
21
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. ( 15860919 )
2005
22
Spindle cell hemangioma. ( 12859394 )
2003
23
Spindle cell hemangioma. ( 10592415 )
1999
24
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. ( 10223237 )
1999

Variations for Spindle Cell Hemangioma

Expression for Spindle Cell Hemangioma

Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for Spindle Cell Hemangioma

Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 IDH1 IDH2
2
Show member pathways
9.74 IDH1 IDH2

GO Terms for Spindle Cell Hemangioma

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.26 IDH1 IDH2
2 2-oxoglutarate metabolic process GO:0006103 9.16 IDH1 IDH2
3 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
4 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.26 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
3 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Spindle Cell Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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