SCH
MCID: SPN012
MIFTS: 30

Spindle Cell Hemangioma (SCH)

Categories: Cancer diseases, Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Spindle Cell Hemangioma

MalaCards integrated aliases for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 12 59 15 72
Sch 12 75 17
Spindle Cell Hemangioendothelioma 59

Classifications:



External Ids:

Disease Ontology 12 DOID:496
NCIt 50 C4754
ICD10 via Orphanet 34 D18.0
UMLS via Orphanet 73 C1304508
Orphanet 59 ORPHA210584
UMLS 72 C1304508

Summaries for Spindle Cell Hemangioma

MalaCards based summary : Spindle Cell Hemangioma, also known as sch, is related to multiple enchondromatosis, maffucci type and enchondroma. An important gene associated with Spindle Cell Hemangioma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1), and among its related pathways/superpathways is Cytosine methylation. Affiliated tissues include bone, spleen and spinal cord.

Wikipedia : 75 Hemangioendotheliomas are a family of vascular neoplasms of intermediate... more...

Related Diseases for Spindle Cell Hemangioma

Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 multiple enchondromatosis, maffucci type 31.1 IDH2 IDH1
2 enchondroma 30.6 IDH2 IDH1
3 enchondromatosis, multiple, ollier type 30.3 IDH2 IDH1
4 hemangioendothelioma 11.7
5 hemangioma 10.7
6 interval angle-closure glaucoma 10.5 IDH2 IDH1
7 adult oligodendroglioma 10.5 IDH2 IDH1
8 intracranial chondrosarcoma 10.5 IDH2 IDH1
9 cytogenetically normal acute myeloid leukemia 10.5 IDH2 IDH1
10 chondroblastic osteosarcoma 10.5 IDH2 IDH1
11 intraductal papilloma 10.5 IDH2 IDH1
12 pilocytic astrocytoma of cerebellum 10.5 IDH2 IDH1
13 periosteal chondrosarcoma 10.5 IDH2 IDH1
14 glioma susceptibility 1 10.4 IDH2 IDH1
15 fibrillary astrocytoma 10.4 IDH2 IDH1
16 adult astrocytic tumour 10.4 IDH2 IDH1
17 diffuse infiltrative lymphocytosis syndrome 10.4 IDH2 IDH1
18 undifferentiated pleomorphic sarcoma 10.4 IDH2 IDH1
19 drug psychosis 10.4 IDH2 IDH1
20 drug-induced mental disorder 10.4 IDH2 IDH1
21 2-hydroxyglutaric aciduria 10.4 IDH2 IDH1
22 d-2-hydroxyglutaric aciduria 1 10.4 IDH2 IDH1
23 bile duct adenocarcinoma 10.3 IDH2 IDH1
24 encephalitis 10.3
25 hepatitis c virus 10.3
26 tick-borne encephalitis 10.3
27 brain stem glioma 10.3 IDH2 IDH1
28 bronchitis 10.3
29 haemophilus influenzae 10.3
30 cerebrum cancer 10.3 IDH2 IDH1
31 supratentorial cancer 10.2 IDH2 IDH1
32 hypothyroidism 10.2
33 central nervous system cancer 10.1 IDH2 IDH1
34 epithelioid hemangioendothelioma 10.1
35 lipomatosis, multiple 10.1
36 pleomorphic lipoma 10.1
37 sarcoma 10.1
38 osteogenic sarcoma 10.1
39 aspergillosis 10.1
40 neutropenia 10.1
41 blastomycosis 10.1
42 candidiasis 10.1
43 hypereosinophilic syndrome 10.1
44 allergic rhinitis 10.1
45 human immunodeficiency virus type 1 10.1
46 visual epilepsy 10.1
47 cryptococcosis 10.1
48 diarrhea 10.1
49 coccidioidomycosis 10.1
50 hepatitis c 10.1

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to Spindle Cell Hemangioma

Symptoms & Phenotypes for Spindle Cell Hemangioma

Drugs & Therapeutics for Spindle Cell Hemangioma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

Anatomical Context for Spindle Cell Hemangioma

MalaCards organs/tissues related to Spindle Cell Hemangioma:

41
Bone, Spleen, Spinal Cord, Endothelial, Liver, Lung, Lymph Node

Publications for Spindle Cell Hemangioma

Articles related to Spindle Cell Hemangioma:

(show top 50) (show all 118)
# Title Authors PMID Year
1
Successful treatment of spindle cell hemangiomas in a patient with Maffucci syndrome and review of literatures. 38
30977938 2019
2
Multiple spindle cell hemangiomas in both lungs: a rare case report and review of the literature. 38
31046794 2019
3
The Molecular Diagnostics of Vascular Neoplasms. 38
30709447 2019
4
Spindle cell hemangioma of the spleen: A case report. 38
30817572 2019
5
Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia. 38
29445571 2018
6
Spindle Cell Hemangioma in the Mucosa of the Upper Lip: A Case Report and Review of the Literature. 38
29780644 2018
7
Mutational analysis using Sanger and next generation sequencing in sporadic spindle cell hemangiomas: A study of 19 cases. 38
28845532 2017
8
Spindle Cell Hemangioma of the Midfoot: A Case Report. 38
29242801 2017
9
[Spindle cell hemangioma: a clinicopathologic analysis of 3 cases]. 38
28591992 2017
10
Histopathology of Spindle Cell Vascular Tumors. 38
28477885 2017
11
Percutaneous cryotherapy for pain treatment of spindle cell hemangioendothelioma of the hand. 38
28161304 2017
12
Spindle cell haemangioma of the tongue. 38
27445035 2016
13
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. 38
26945705 2016
14
Intramedullary spindle cell hemangioma: case report. 38
27058496 2016
15
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions. 38
27318413 2016
16
Multifocal spindle cell hemangioma: Report of two cases. 38
26728826 2016
17
[Spindle-shaped hemangioma: an unusual location]. 38
27642429 2016
18
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. 38
26980977 2015
19
Spindle Cell Hemangioendothelioma: Rare Clinical Entity. 38
26538705 2015
20
Spindle cell hemangioma of thyroid. 38
26905134 2015
21
Angiosarcoma of the pericardium: a case report. 38
26722576 2015
22
Spindle cell hemangioendothelioma of the sacrum: case report. 38
24785972 2014
23
A spindle cell hemangioendothelioma on the head resembling an arteriovenous malformation. 38
24978448 2014
24
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. 38
24673328 2014
25
Periosteal spindle cell hemangioma of the fibula: a case report. 38
23525489 2013
26
Maffucci syndrome with the spindle cell hemangiomas in the mucosa of the lower lip: a rare case report and literature review. 38
23506121 2013
27
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. 38
23485734 2013
28
Hemangioendothelioma. 38
23327728 2013
29
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. 38
22534243 2012
30
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. 38
22927295 2012
31
Spindle cell hemangioma reoccurrence in the hand: case report. 38
23730241 2012
32
Prox1 transcription factor as a marker for vascular tumors-evaluation of 314 vascular endothelial and 1086 nonvascular tumors. 38
22067331 2012
33
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. 38
22057234 2011
34
Wilms tumor 1 expression in vascular neoplasms and vascular malformations. 38
21697701 2011
35
[Vascular tumors and pseudo-tumors. Spindle-cell hemangioma]. 38
21839351 2011
36
Hemangioma related to Maffucci syndrome in a man: a case report. 38
21689466 2011
37
Spindle cell hemangioendothelioma of the temporal muscle resected with zygomatic osteotomy: a case report of an unusual intramuscular lesion mimicking sarcoma. 38
22606579 2011
38
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. 38
20860749 2010
39
Reactive proliferation of endothelial cells and pericytes associated with arteriovenous malformation. 38
20507408 2010
40
Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity. 38
20196675 2010
41
[Spindle cell hemangioma in frontal bone: report of a case]. 38
20388381 2010
42
Do intracranial neoplasms differ in Ollier disease and maffucci syndrome? An in-depth analysis of the literature. 38
19934970 2009
43
Composite cutaneous hemangioendothelioma on the back. 38
18496428 2008
44
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. 38
17656123 2008
45
Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases. 38
18190450 2008
46
Surgical management of gynecomastia--a 10-year analysis. 38
18026791 2008
47
Eccrine angiomatous hamartoma with features resembling verrucous hemangioma. 38
17997743 2007
48
Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome. 38
17895759 2007
49
Spindle cell hemangioma: report of a case presenting in the oral cavity. 38
17880587 2007
50
Spindle cell hemangioendothelioma. 38
17388212 2007

Variations for Spindle Cell Hemangioma

Expression for Spindle Cell Hemangioma

Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for Spindle Cell Hemangioma

Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
9.74 IDH2 IDH1

GO Terms for Spindle Cell Hemangioma

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.32 IDH2 IDH1
2 2-oxoglutarate metabolic process GO:0006103 9.26 IDH2 IDH1
3 NADP metabolic process GO:0006739 9.16 IDH2 IDH1
4 isocitrate metabolic process GO:0006102 8.96 IDH2 IDH1
5 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxylic ester hydrolase activity GO:0052689 9.32 SIAE ACOT1
2 NAD binding GO:0051287 9.26 IDH2 IDH1
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH2 IDH1
4 isocitrate dehydrogenase activity GO:0004448 8.96 IDH2 IDH1
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH2 IDH1

Sources for Spindle Cell Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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