SCH
MCID: SPN012
MIFTS: 33

Spindle Cell Hemangioma (SCH)

Categories: Cancer diseases, Cardiovascular diseases, Fetal diseases, Rare diseases
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Aliases & Classifications for Spindle Cell Hemangioma

MalaCards integrated aliases for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 11 58 28 14 71 75
Sch 11 75 16
Spindle Cell Hemangioendothelioma 58

Characteristics:


Age Of Onset:

Adolescent,Adult,Childhood,Elderly 58

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 11 DOID:496
NCIt 49 C4754
SNOMED-CT 68 128769003
ICD10 via Orphanet 32 D18.0
UMLS via Orphanet 72 C1304508
Orphanet 58 ORPHA210584
UMLS 71 C1304508

Summaries for Spindle Cell Hemangioma

Orphanet: 58 Spindle cell hemangioma (SCH), also known as spindle cell hemangioendothelioma, is a rare benign vascular tumor either solitary or multiple, characterized by cavernous blood vessels separated by spindle cells reminiscent of those in Kaposi’s sarcoma and located in the dermis and subcutis.

MalaCards based summary: Spindle Cell Hemangioma, also known as sch, is related to hemangioendothelioma and hemangioma. An important gene associated with Spindle Cell Hemangioma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2). Affiliated tissues include spinal cord, lymph node and spleen.

Wikipedia: 75 Hemangioendotheliomas are a family of vascular neoplasms of intermediate... more...

Related Diseases for Spindle Cell Hemangioma

Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 424)
# Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 31.7 FOSB CD34 CAMTA1
2 hemangioma 30.9 PROX1 PECAM1 IDH1 GNA14 CD34
3 enchondroma 30.5 IDH2 IDH1
4 vascular cancer 30.4 PECAM1 CD34 CAMTA1
5 intramuscular hemangioma 30.4 PECAM1 CD34
6 epithelioid hemangioendothelioma 30.2 PECAM1 CD34 CAMTA1
7 lymphangioma 30.1 PROX1 PECAM1 CD34
8 cavernous hemangioma 30.1 PECAM1 GNA14 CD34
9 angiosarcoma 30.1 PECAM1 CD34 CAMTA1
10 enchondromatosis, multiple, ollier type 30.1 PTH1R IDH2 IDH1
11 arteriovenous malformation 30.0 PECAM1 GLMN CD34
12 multiple enchondromatosis, maffucci type 29.9 PTH1R IDH2 IDH1 GNA14
13 histiocytoid hemangioma 29.8 PECAM1 FOSB CD34 CAMTA1
14 rapidly involuting congenital hemangioma 29.8 PECAM1 GNA14 CAMTA1
15 acute promyelocytic leukemia 29.2 WT1 IDH2 IDH1 CD34
16 composite hemangioendothelioma 11.2
17 henoch-schoenlein purpura 11.0
18 aspergillosis 10.4
19 chondroma 10.3 IDH2 IDH1
20 histoplasmosis meningitis 10.3 IDH2 IDH1
21 intracranial chondrosarcoma 10.3 IDH2 IDH1
22 anaplastic oligodendroglioma, idh-mutant and 1p/19q-codeleted 10.3 IDH2 IDH1
23 periosteal chondrosarcoma 10.3 IDH2 IDH1
24 juxtacortical chondroma 10.3 IDH2 IDH1
25 idh-mutant anaplastic astrocytoma 10.3 IDH2 IDH1
26 idh-wildtype anaplastic astrocytoma 10.3 IDH2 IDH1
27 spinal cord astrocytoma 10.3 IDH2 IDH1
28 adult oligodendroglioma 10.3 IDH2 IDH1
29 childhood oligodendroglioma 10.3 IDH2 IDH1
30 astrocytoma, idh-mutant, grade 4 10.3 IDH2 IDH1
31 sinonasal undifferentiated carcinoma 10.3 IDH2 IDH1
32 asthma 10.3
33 angiomyoma 10.3 PECAM1 CD34
34 d-2-hydroxyglutaric aciduria 2 10.3 IDH2 IDH1
35 2-hydroxyglutaric aciduria 10.3 IDH2 IDH1
36 generalized lymphatic anomaly 10.3 PROX1 PECAM1
37 skin epithelioid hemangioma 10.3 PECAM1 CD34
38 aorta angiosarcoma 10.3 PECAM1 CD34
39 central nervous system angiosarcoma 10.3 PECAM1 CD34
40 chondroblastic osteosarcoma 10.3 IDH2 IDH1
41 intravascular angioleiomyoma 10.3 PECAM1 CD34
42 prostate angiosarcoma 10.3 PECAM1 CD34
43 heart fibrosarcoma 10.3 PECAM1 CD34
44 thyroid angiosarcoma 10.3 PECAM1 CD34
45 glomeruloid hemangioma 10.3 PECAM1 CD34
46 conventional angiosarcoma 10.3 PECAM1 CD34
47 gemistocytic astrocytoma 10.3 IDH2 IDH1
48 gallbladder leiomyosarcoma 10.3 PECAM1 CD34
49 central nervous system hemangioma 10.3 PECAM1 CD34
50 venous hemangioma 10.3 PECAM1 CD34

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to Spindle Cell Hemangioma

Symptoms & Phenotypes for Spindle Cell Hemangioma

Drugs & Therapeutics for Spindle Cell Hemangioma

Search Clinical Trials, NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

Genetic tests related to Spindle Cell Hemangioma:

# Genetic test Affiliating Genes
1 Spindle Cell Hemangioma 28

Anatomical Context for Spindle Cell Hemangioma

Organs/tissues related to Spindle Cell Hemangioma:

MalaCards : Spinal Cord, Lymph Node, Spleen, Bone, Endothelial, Cervix, Lung

Publications for Spindle Cell Hemangioma

Articles related to Spindle Cell Hemangioma:

(show top 50) (show all 134)
# Title Authors PMID Year
1
Spindle cell hemangioma of the lung: An unusual presentation. 62
36258695 2022
2
Epithelioid and Spindle Cell Hemangioma: Clinicopathologic Analysis of 18 Primary Bone and Soft Tissue Tumors Highlighting a Predilection for the Hands and Feet, Frequent Multicentricity, and Benign Behavior. 62
36206448 2022
3
[Spindle cell hemangioma in the sternum: report of a case]. 62
36097912 2022
4
My time with Franz Enzinger at the Armed Forces Institute of Pathology. 62
35278805 2022
5
The First Case of Composite Hemangioendothelioma in The Heart. 62
35486043 2022
6
Rare spindle cell hemangioma of bone: Case report and literature review. 62
35059093 2022
7
[Spindle cell hemangioma: a clinicopathological and molecular analysis of eight cases]. 62
35249281 2022
8
Spindle Cell Hemangioma of the Lung: A Case Report. 62
35178307 2022
9
Somatic IDH1 variant (p.R132C) in an adult male with Maffucci syndrome. 62
34588213 2021
10
Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report. 62
33546375 2021
11
Spindle cell hemangioma of nasal passage and ethmoidal sinus in a 4-month old infant. 62
33458988 2021
12
Spindle cell hemangioma in the infratemporal fossa: A unique case report. 62
33310467 2021
13
Successful Outcome After Intralesional Curettage for Spindle Cell Hemangioma of Fibula in an Infant: A Case Report. 62
34805052 2021
14
Concurrent Spindle Cell Hemangioma and Schwannoma of the Jugular Foramina. 62
32810020 2020
15
Composite Hemangioendothelioma With Neuroendocrine Marker Expression: Report of a "Paraganglioma-Like" Paravertebral Case. 62
32418470 2020
16
Intramuscular composite hemangioendothelioma: case report of an unusual tumor in an unusual location. 62
32661479 2020
17
Successful treatment of spindle cell hemangiomas in a patient with Maffucci syndrome and review of literatures. 62
30977938 2019
18
Multiple spindle cell hemangiomas in both lungs: a rare case report and review of the literature. 62
31046794 2019
19
The Molecular Diagnostics of Vascular Neoplasms. 62
30709447 2019
20
Spindle cell hemangioma of the spleen: A case report. 62
30817572 2019
21
Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia. 62
29445571 2018
22
Spindle Cell Hemangioma in the Mucosa of the Upper Lip: A Case Report and Review of the Literature. 62
29780644 2018
23
Mutational analysis using Sanger and next generation sequencing in sporadic spindle cell hemangiomas: A study of 19 cases. 62
28845532 2017
24
Spindle Cell Hemangioma of the Midfoot: A Case Report. 62
29242801 2017
25
[Spindle cell hemangioma: a clinicopathologic analysis of 3 cases]. 62
28591992 2017
26
Percutaneous cryotherapy for pain treatment of spindle cell hemangioendothelioma of the hand. 62
28161304 2017
27
Histopathology of Spindle Cell Vascular Tumors. 62
28477885 2017
28
Spindle cell haemangioma of the tongue. 62
27445035 2016
29
Intramedullary spindle cell hemangioma: case report. 62
27058496 2016
30
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. 62
26945705 2016
31
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions. 62
27318413 2016
32
[Spindle-shaped hemangioma: an unusual location]. 62
27642429 2016
33
Multifocal spindle cell hemangioma: Report of two cases. 62
26728826 2016
34
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. 62
26980977 2015
35
Spindle Cell Hemangioendothelioma: Rare Clinical Entity. 62
26538705 2015
36
Spindle cell hemangioma of thyroid. 62
26905134 2015
37
Angiosarcoma of the pericardium: a case report. 62
26722576 2015
38
Spindle cell hemangioendothelioma of the sacrum: case report. 62
24785972 2014
39
A spindle cell hemangioendothelioma on the head resembling an arteriovenous malformation. 62
24978448 2014
40
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. 62
24673328 2014
41
Periosteal spindle cell hemangioma of the fibula: a case report. 62
23525489 2013
42
Maffucci syndrome with the spindle cell hemangiomas in the mucosa of the lower lip: a rare case report and literature review. 62
23506121 2013
43
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. 62
23485734 2013
44
Hemangioendothelioma. 62
23327728 2013
45
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. 62
22534243 2012
46
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. 62
22927295 2012
47
Spindle cell hemangioma reoccurrence in the hand: case report. 62
23730241 2012
48
Prox1 transcription factor as a marker for vascular tumors-evaluation of 314 vascular endothelial and 1086 nonvascular tumors. 62
22067331 2012
49
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. 62
22057234 2011
50
Wilms tumor 1 expression in vascular neoplasms and vascular malformations. 62
21697701 2011

Variations for Spindle Cell Hemangioma

Expression for Spindle Cell Hemangioma

Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for Spindle Cell Hemangioma

GO Terms for Spindle Cell Hemangioma

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vasculogenesis GO:0001570 9.8 WT1 RASIP1 GLMN
2 2-oxoglutarate metabolic process GO:0006103 9.71 IDH2 IDH1
3 NADP metabolic process GO:0006739 9.67 IDH2 IDH1
4 isocitrate metabolic process GO:0006102 9.56 IDH2 IDH1
5 glomerular endothelium development GO:0072011 9.46 PECAM1 CD34
6 positive regulation of heart growth GO:0060421 9.26 WT1 PROX1
7 glyoxylate cycle GO:0006097 8.92 IDH2 IDH1

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.92 IDH2 IDH1

Sources for Spindle Cell Hemangioma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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