MCID: SPN006
MIFTS: 34

Spindle Cell Lipoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Lipoma

MalaCards integrated aliases for Spindle Cell Lipoma:

Name: Spindle Cell Lipoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10184
NCIt 50 C4254
SNOMED-CT 67 404058008
UMLS 70 C0334474

Summaries for Spindle Cell Lipoma

Disease Ontology : 12 A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.

MalaCards based summary : Spindle Cell Lipoma is related to pleomorphic lipoma and lipomatosis, multiple. An important gene associated with Spindle Cell Lipoma is CD34 (CD34 Molecule), and among its related pathways/superpathways are Measles and DNA Damage Response. Affiliated tissues include breast, tongue and skin, and related phenotypes are Reduced mammosphere formation and cellular

Wikipedia : 73 Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the... more...

Related Diseases for Spindle Cell Lipoma

Diseases related to Spindle Cell Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.5 MDM2 CDK4 CD34
2 lipomatosis, multiple 31.2 MDM2 DES CDK4 CD34
3 neurofibroma 30.6 VIM CD34 ACTC1
4 rare tumor 30.6 DES ACTC1
5 well-differentiated liposarcoma 30.5 MDM2 CDK4 CD34
6 neurilemmoma 30.4 VIM DES CD34 ACTC1
7 perineurioma 30.4 VIM ACTC1
8 angiomyolipoma 30.1 VIM DES ACTC1
9 mesenchymal cell neoplasm 30.1 NAB2 CD34
10 fasciitis 30.1 VIM CD34 ACTC1
11 leiomyoma 30.1 VIM DES CD34 ACTC1
12 pleomorphic adenoma 30.0 VIM MDM2 DES ACTC1
13 lipoblastoma 30.0 MDM2 CDK4
14 liposarcoma 30.0 VIM RB1 MDM2 DES CDK4 CD34
15 infiltrating lipoma 29.9 MDM2 CDK4 CD34
16 myositis ossificans 29.9 MDM2 CDK4
17 fibrous histiocytoma 29.9 VIM DES CD34 ACTC1
18 cutaneous fibrous histiocytoma 29.9 VIM DES CD34 ACTC1
19 angiolipoma 29.8 VIM MDM2 DES CD34 ACTC1
20 spindle cell liposarcoma 29.7 MDM2 CDK4 CD34
21 fibroma 29.4 VIM S100A9 DES CD99 CD34 ACTC1
22 dermatofibrosarcoma protuberans 29.3 VIM DES CDK4 CD99 CD34 ACTC1
23 pseudosarcomatous fibromatosis 29.2 VIM NAB2 DES CD34 ACTC1
24 hemangiopericytoma, malignant 28.5 VIM NAB2 MDM2 DES CD99 CD34
25 dedifferentiated liposarcoma 28.2 RB1 NAB2 MDM2 DES CDK4 CD34
26 retinoblastoma 10.4
27 fibroblastic rheumatism 10.3 DES ACTC1
28 ovarian fibrothecoma 10.3 DES ACTC1
29 myofibroma 10.3 DES CD34
30 infantile digital fibromatosis 10.3 VIM DES
31 adult cystic nephroma 10.3 DES ACTC1
32 primitive neuroectodermal tumor of the cervix uteri 10.3 VIM DES
33 lymphangiectasis 10.3 VIM ACTC1
34 lymphangiomatosis 10.3 VIM DES
35 mesenchymal chondrosarcoma 10.3 VIM DES
36 congenital epulis 10.3 VIM DES
37 epulis 10.3 VIM DES
38 intravascular papillary endothelial hyperplasia 10.3 VIM ACTC1
39 botryoid rhabdomyosarcoma 10.3 DES ACTC1
40 myxoid liposarcoma 10.3
41 dysphagia 10.3
42 granular cell tumor 10.3 VIM DES
43 angiocentric glioma 10.3 VIM ACTC1
44 cervical polyp 10.3 DES CD34
45 intravenous leiomyomatosis 10.3 DES CD34
46 non-langerhans-cell histiocytosis 10.2 DES ACTC1
47 liver fibroma 10.2 VIM CD34
48 biphasic synovial sarcoma 10.2 VIM DES
49 polymorphous low-grade adenocarcinoma 10.2 VIM ACTC1
50 vaginal endometrial stromal sarcoma 10.2 VIM CD34

Graphical network of the top 20 diseases related to Spindle Cell Lipoma:



Diseases related to Spindle Cell Lipoma

Symptoms & Phenotypes for Spindle Cell Lipoma

GenomeRNAi Phenotypes related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD34 CDK4 DES MDM2 S100A9 VIM

MGI Mouse Phenotypes related to Spindle Cell Lipoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 ACTC1 CD34 CDK4 DES MDM2 NAB2
2 hematopoietic system MP:0005397 9.86 ACTC1 CD34 CDK4 MDM2 NAB2 RB1
3 homeostasis/metabolism MP:0005376 9.81 ACTC1 CD34 CDK4 DES MDM2 NAB2
4 muscle MP:0005369 9.43 ACTC1 CDK4 DES MDM2 RB1 VIM
5 normal MP:0002873 9.1 ACTC1 CDK4 MDM2 NAB2 RB1 VIM

Drugs & Therapeutics for Spindle Cell Lipoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Lipoma

Genetic Tests for Spindle Cell Lipoma

Anatomical Context for Spindle Cell Lipoma

MalaCards organs/tissues related to Spindle Cell Lipoma:

40
Breast, Tongue, Skin, Bone, Small Intestine, Adipocyte, Kidney

Publications for Spindle Cell Lipoma

Articles related to Spindle Cell Lipoma:

(show top 50) (show all 342)
# Title Authors PMID Year
1
Coexistence of three nevus lipomatosus cutaneus superficialis with typical, cutaneous adenolipoma-like, and dermal spindle cell lipoma-like histopathological features in a patient. 61
33713046 2021
2
A fat tumor goes on a diet: Rare case of low-fat spindle cell lipoma. 61
33527490 2021
3
A report of a patient presenting with three metachronous 13q14LOH mesenchymal tumours: spindle cell lipoma, cellular angiofibroma and mammary myofibroblastoma. 61
33392798 2021
4
Spindle Cell Lipoma Arising from the Supraglottis: A Case Report and Review of the Literature. 61
33394369 2021
5
Dendritic fibromyxolipoma: A case report. 61
33262887 2021
6
Telocytes/CD34+ Stromal Cells in Pathologically Affected White Adipose Tissue. 61
33353193 2020
7
Lipoma arborescens - Uncommon Diagnosis for Joint Swelling: Case Report and Review of the Literature. 61
31746441 2020
8
Cutaneous side effects in a cohort of patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: General description and further characterization, correlation with photoexposition and study of hypopigmentation as treatment's prognostic factor. 61
33073453 2020
9
"The unusual suspects"-Mammographic, sonographic, and histopathologic appearance of atypical breast masses. 61
32470708 2020
10
Intrasynovial spindle cell lipoma of the deep flexor of the middle finger causing intermittent carpal tunnel syndrome-case report and review of the literature. 61
29429014 2020
11
Atypical Spindle Cell Lipomatous Lesion Resected From Patient With History of CLL. 61
32683914 2020
12
A Novel Case of Mammary-Type Myofibroblastoma With Sarcomatous Features. 61
32752900 2020
13
Spindle cell lipoma of the larynx: A case report. 61
32702862 2020
14
Primary pleural liposarcoma combined spindle cell lipoma of the lung. 61
32438529 2020
15
Intrathoracic Myxoid Spindle Cell Lipoma: A Rare Presentation of a Myxoid Neoplasm. 61
31589846 2020
16
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma With Features Mimicking Spindle Cell Lipoma. 61
31672072 2020
17
Imaging of spindle cell lipoma. 61
31932047 2020
18
Spindle cell lipoma, dorsum of hand in a 4 year old child: A rare entity. 61
32317540 2020
19
Bucco-Parapharyngeal Occurrence of Pleomorphic Spindle Cell Lipoma-A Unique Entity: Case Report. 61
32271663 2020
20
A Rare Cause of Cough: Tracheobronchial Myxoid Spindle Cell Lipoma. 61
32551146 2020
21
Diagnostic importance of clinicopathologic features and p16, CD34, MDM2 expression in differential diagnosis of adipocytic tumors. 61
32175898 2020
22
The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour. 61
32566457 2020
23
A Painless Restricted Motion of the Thumb: What Etiology? About An Uncommon Tumor in Uncommon Localization. 61
32550032 2020
24
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast. 61
31965112 2019
25
Spindle Cell Lipomas of the Respiratory Tract: A Case Report and Comprehensive Literature Review. 61
31291740 2019
26
"Low- fat" pseudoangiomatous spindle cell lipoma. 61
31187478 2019
27
Exceptionally large, atypically located spindle cell lipoma. 61
31676502 2019
28
Spindle Cell Predominant Trichodiscoma or Spindle Cell Lipoma With Adnexal Induction? A Study of 25 Cases, Revealing a Subset of Cases With RB1 Heterozygous Deletion in the Spindle Cell Stroma. 61
30908293 2019
29
Fat-forming variant of solitary fibrous tumor of the pleura, mimicking spindle cell lipoma. 61
30983082 2019
30
Spindle cell lipoma mimicking pleomorphic adenoma: A diagnostic challenge on cytology. 61
30468314 2019
31
A 37 mm Spindle Cell Lipoma on the Floor of the Mouth. 61
31482039 2019
32
Spindle cell lipoma: clinicopathologic characterization of 40 cases. 61
31934089 2019
33
[Primary Orbital Liposarcoma]. 61
30567006 2019
34
Lipoblastoma-like tumor of the vulva: a clinicopathologic, immunohistochemical, fluorescence in situ hybridization and genomic copy number profiling study of seven cases. 61
29976943 2018
35
Utility of STAT6 and 13q14 deletion in the classification of the benign spindle cell stromal tumors of the breast. 61
29940288 2018
36
Dysplastic Lipoma: A Distinctive Atypical Lipomatous Neoplasm With Anisocytosis, Focal Nuclear Atypia, p53 Overexpression, and a Lack of MDM2 Gene Amplification by FISH; A Report of 66 Cases Demonstrating Occasional Multifocality and a Rare Association With Retinoblastoma. 61
30001242 2018
37
Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10. 61
30303149 2018
38
Molecular Signature of Tumors with Monoallelic 13q14 Deletion: a Case Series of Spindle Cell Lipoma and Genetically-Related Tumors Demonstrating a Link Between FOXO1 Status and p38 MAPK Pathway. 61
28887603 2018
39
STAT6 expression in spindle cell lesions of the breast: An immunohistochemical study of 48 cases. 61
30072169 2018
40
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component. 61
29358476 2018
41
[Spindle cell lipoma and pleomorphic lipoma: a clinicopathologic analysis of 65 cases]. 61
29690665 2018
42
Differential Diagnosis of Benign Spindle Cell Lesions. 61
29413661 2018
43
Adipocyte size variability in benign and malignant lipomatous tumors and morphologic mimics: a quantitative definition using digital pathology. 61
29128479 2018
44
Spindle Cell Lipoma of the Thumb. 61
29616170 2018
45
Cytopathological Diagnosis and Differential Diagnoses of Facial Spindle Cell Lipoma. 61
29403177 2018
46
[Dendritic infraclavicular fibromyxolipoma: At the boundary between spindle cell lipoma and solitary fibrous tumour]. 61
29290323 2018
47
Low-fat, plexiform spindle cell lipoma of the lip expressing S100 protein: a neural tumor simulator. 61
29940654 2018
48
Incidental, low-fat variant of spindle cell lipoma: a novel tumour of the small intestine. 61
29895131 2018
49
Combined classical spindle cell/pleomorphic lipoma spectrum imaging and clinical data. 61
28823067 2018
50
Pleomorphic fibroma of the skin with MDM2 immunoreactivity: A potential diagnostic pitfall. 61
28981153 2018

Variations for Spindle Cell Lipoma

Expression for Spindle Cell Lipoma

Search GEO for disease gene expression data for Spindle Cell Lipoma.

Pathways for Spindle Cell Lipoma

GO Terms for Spindle Cell Lipoma

Biological processes related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 VIM MDM2 CD34 ACTC1
2 positive regulation of cell cycle GO:0045787 9.4 MDM2 CDK4
3 negative regulation of cell cycle arrest GO:0071157 9.37 MDM2 CDK4
4 tissue homeostasis GO:0001894 9.32 RB1 CD34
5 intermediate filament organization GO:0045109 9.16 VIM DES
6 astrocyte development GO:0014002 8.96 VIM S100A9
7 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 RB1 MDM2

Sources for Spindle Cell Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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