MCID: SPN006
MIFTS: 38

Spindle Cell Lipoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Lipoma

MalaCards integrated aliases for Spindle Cell Lipoma:

Name: Spindle Cell Lipoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10184
NCIt 50 C4254
SNOMED-CT 68 27313007 404058008
UMLS 73 C0334474

Summaries for Spindle Cell Lipoma

Disease Ontology : 12 A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.

MalaCards based summary : Spindle Cell Lipoma is related to pleomorphic lipoma and dermatofibrosarcoma protuberans. An important gene associated with Spindle Cell Lipoma is DES (Desmin), and among its related pathways/superpathways are ERK Signaling and PI3K-Akt signaling pathway. Affiliated tissues include tongue, skin and adipocyte, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Wikipedia : 76 Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the... more...

Related Diseases for Spindle Cell Lipoma

Diseases related to Spindle Cell Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.6 CDK4 MDM2
2 dermatofibrosarcoma protuberans 30.0 ACTC1 DES VIM
3 atypical lipomatous tumor 29.5 CDK4 MDM2
4 pleomorphic adenoma 29.3 ACTC1 MDM2 VIM
5 spindle cell liposarcoma 29.3 CDK4 MDM2
6 well-differentiated liposarcoma 29.3 CDK4 MDM2
7 infiltrating lipoma 29.2 CDK4 MDM2
8 hemangiopericytoma, malignant 29.1 ACTC1 DES MDM2 VIM
9 liposarcoma 28.5 CDK4 DES MDM2 VIM
10 retinoblastoma 28.3 CDK4 MDM2 RB1
11 infantile digital fibromatosis 10.6 DES VIM
12 lymphangiomatosis 10.6 DES VIM
13 primitive neuroectodermal tumor of the cervix uteri 10.6 DES VIM
14 epulis 10.6 DES VIM
15 biphasic synovial sarcoma 10.6 DES VIM
16 ovarian fibrothecoma 10.5 ACTC1 DES
17 syringoma 10.5 DES VIM
18 fibroblastic rheumatism 10.5 ACTC1 DES
19 juvenile xanthogranuloma 10.5 DES VIM
20 cutaneous leiomyosarcoma 10.5 ACTC1 DES
21 desmoplastic small round cell tumor 10.5 DES VIM
22 botryoid rhabdomyosarcoma 10.5 ACTC1 DES
23 lymphangiectasis 10.5 ACTC1 VIM
24 mesenchymal chondrosarcoma 10.5 DES VIM
25 glomangiomyoma 10.5 ACTC1 VIM
26 extraskeletal ewing sarcoma 10.5 DES VIM
27 intravascular papillary endothelial hyperplasia 10.5 ACTC1 VIM
28 pulmonary vein stenosis 10.5 ACTC1 DES
29 cystic nephroma 10.5 ACTC1 DES
30 granular cell tumor 10.5 DES VIM
31 adenofibroma 10.4 ACTC1 VIM
32 congenital epulis 10.4 DES VIM
33 angiocentric glioma 10.4 ACTC1 VIM
34 non-langerhans-cell histiocytosis 10.4 ACTC1 DES
35 bilateral retinoblastoma 10.4 DES RB1
36 dendritic cell tumor 10.3 ACTC1 VIM
37 mesenchymoma 10.3 DES MDM2
38 granulosa cell tumor of the ovary 10.3 ACTC1 VIM
39 polymorphous low-grade adenocarcinoma 10.3 ACTC1 VIM
40 retroperitoneal fibrosis 10.3 MDM2 VIM
41 angiomyolipoma 10.3 ACTC1 DES
42 neurilemmoma 10.3 DES VIM
43 familial isolated dilated cardiomyopathy 10.3 ACTC1 DES
44 myoepithelioma 10.2 ACTC1 VIM
45 anaplastic ependymoma 10.2 MDM2 VIM
46 uterine sarcoma 10.1 DES MDM2
47 angiolipoma 10.1 ACTC1 DES VIM
48 parachordoma 10.1 ACTC1 DES VIM
49 ossifying fibromyxoid tumor 10.1 ACTC1 DES VIM
50 epithelioid leiomyosarcoma 10.1 ACTC1 DES VIM

Graphical network of the top 20 diseases related to Spindle Cell Lipoma:



Diseases related to Spindle Cell Lipoma

Symptoms & Phenotypes for Spindle Cell Lipoma

GenomeRNAi Phenotypes related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CDK4 DES FOXO1 MDM2 VIM

MGI Mouse Phenotypes related to Spindle Cell Lipoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 RB1 DES FOXO1 VIM ACTC1 MDM2
2 cellular MP:0005384 9.98 RB1 DES FOXO1 VIM ACTC1 MDM2
3 behavior/neurological MP:0005386 9.95 MDM2 CDK4 RB1 DES FOXO1 VIM
4 homeostasis/metabolism MP:0005376 9.91 RB1 DES FOXO1 VIM ACTC1 MDM2
5 mortality/aging MP:0010768 9.87 CDK4 RB1 DES FOXO1 ACTC1 MDM2
6 embryo MP:0005380 9.8 CDK4 RB1 FOXO1 MDM2 VIM
7 muscle MP:0005369 9.8 RB1 DES FOXO1 VIM ACTC1 MDM2
8 neoplasm MP:0002006 9.46 MDM2 CDK4 RB1 FOXO1
9 normal MP:0002873 9.35 MDM2 CDK4 RB1 FOXO1 ACTC1
10 reproductive system MP:0005389 9.02 MDM2 CDK4 RB1 FOXO1 VIM

Drugs & Therapeutics for Spindle Cell Lipoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Lipoma

Genetic Tests for Spindle Cell Lipoma

Anatomical Context for Spindle Cell Lipoma

MalaCards organs/tissues related to Spindle Cell Lipoma:

41
Tongue, Skin, Adipocyte, Small Intestine, Bone

Publications for Spindle Cell Lipoma

Articles related to Spindle Cell Lipoma:

(show top 50) (show all 174)
# Title Authors Year
1
Cytopathological Diagnosis and Differential Diagnoses of Facial Spindle Cell Lipoma. ( 29403177 )
2018
2
Intrasynovial spindle cell lipoma of the deep flexor of the middle finger causing intermittent carpal tunnel syndrome-case report and review of the literature. ( 29429014 )
2018
3
[Dendritic infraclavicular fibromyxolipoma: At the boundary between spindle cell lipoma and solitary fibrous tumour]. ( 29290323 )
2018
4
Incidental, low-fat variant of spindle cell lipoma: a novel tumour of the small intestine. ( 29895131 )
2018
5
Spindle Cell Lipoma of the Thumb. ( 29616170 )
2018
6
Low-fat, plexiform spindle cell lipoma of the lip expressing S100 protein: a neural tumor simulator. ( 29940654 )
2018
7
Spindle cell lipoma with prominent Verocay bodies: A potential diagnostic pitfall. ( 28139026 )
2017
8
Cytohistological Features of Spindle Cell Lipoma- A Case Report with Differential Diagnosis. ( 28384874 )
2017
9
Anisometric cell lipoma: Insight from a case series and review of the literature on adipocytic neoplasms in survivors of retinoblastoma suggest a role for RB1 loss and possible relationship to fat-predominant ("fat-only") spindle cell lipoma. ( 28807343 )
2017
10
Intraosseous spindle cell lipoma of the mandible: case report. ( 28735633 )
2017
11
Spindle Cell Lipoma in Dogs. ( 28494701 )
2017
12
Cytogenetic Analysis of a Pseudoangiomatous Pleomorphic/Spindle Cell Lipoma. ( 28476785 )
2017
13
Molecular Signature of Tumors with Monoallelic 13q14 Deletion: a Case Series of Spindle Cell Lipoma and Genetically-Related Tumors Demonstrating a Link Between FOXO1 Status and p38 MAPK Pathway. ( 28887603 )
2017
14
Dermal plexiform spindle cell lipoma. ( 27833986 )
2016
15
Low-Fat Plexiform Spindle Cell Lipoma With Prominent Myxoid Stroma: An Unusual Oral Presentation and Immunohistochemical Analysis. ( 28045832 )
2016
16
Pseudoangiomatous variant of spindle cell lipoma: Report of a rare case. ( 27510682 )
2016
17
Spindle Cell Lipoma in an End-Stage Renal Allograft: Case Report. ( 27932168 )
2016
18
Pseudoangiomatous Spindle Cell Lipoma: a distinct subtype of spindle cell lipoma. ( 27982506 )
2016
19
S-100 protein expressing spindle cells in spindle cell lipoma: a diagnostic pitfall. ( 27444171 )
2016
20
Spindle cell lipoma of the soft palate. ( 25878917 )
2015
21
"Low-Fat" Pseudoangiomatous Spindle Cell Lipoma: A Rare Variant With Loss of 13q14 Region. ( 25839893 )
2015
22
Intramuscular spindle cell lipoma of the deltoid: a case report. ( 25880875 )
2015
23
Acute dyspnea caused by a giant spindle cell lipoma of the larynx. ( 26438102 )
2015
24
Spindle cell lipoma with predominant nerve sheath tumor-like areas: A potential diagnostic pitfall on aspiration cytology. ( 26457887 )
2015
25
Diagnostically challenging case of low-fat spindle cell lipoma. ( 26053070 )
2015
26
Spindle Cell Lipoma Occurring in the Buccal Mucosa: An Unusual Location of This Benign Lipomatous Neoplasm. ( 26491592 )
2015
27
Rare occurrence of lip spindle cell lipoma. ( 25815220 )
2015
28
Folliculosebaceous Cystic Hamartoma With Spindle Cell Lipoma-Like Stromal Features. ( 26588344 )
2015
29
Oral Spindle Cell Lipoma in a Rare Location: A Differential Diagnosis. ( 26615969 )
2015
30
Spindle cell lipoma of the tongue. ( 25682756 )
2015
31
Spindle cell lipoma of the wrist, occurring in a distinctly rare location: a case report with review of literature. ( 26045856 )
2015
32
Spindle Cell Lipoma of the Neck: Review of the Literature and Case Report. ( 26893975 )
2015
33
"Low Fat" Spindle Cell Lipoma of the Eyelid: A Diagnostic Challenge. ( 26017060 )
2015
34
Management of a Nasal Spindle Cell Lipoma: Diagnostic and Therapeutic Considerations. ( 26517318 )
2015
35
Letter to the Editor: Re: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case. Response to Laliotis et al. ( 26017887 )
2015
36
Nodular Mucinosis of the Breast in a Male: Reassessment of Diagnostic Criteria and Proposal for Its Classification as a Soft Tissue Tumor in the Myofibroblastoma and Spindle Cell Lipoma Spectrum. ( 27047922 )
2014
37
Spindle Cell Lipoma of the Tongue: A Clinicopathologic Study of 8 Cases and Review of the Literature. ( 25319950 )
2014
38
Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma. ( 24659226 )
2014
39
Spindle Cell Lipoma of the Conjunctiva. ( 24911538 )
2014
40
Dendritic fibromyxolipoma: a variant of spindle cell lipoma with extensive myxoid change, with cytogenetic evidence. ( 25047505 )
2014
41
Spindle cell lipoma adherent to the digital nerve in the palm. ( 25414563 )
2014
42
Imaging characteristics of spindle cell lipoma and its variants. ( 24554024 )
2014
43
RE: "Fat-free" spindle cell lipoma in retropharynx. ( 24843246 )
2014
44
MR imaging features of spindle cell lipoma. ( 24240205 )
2014
45
A rare case of spindle cell lipoma of broad ligament presenting as a pelvic mass. ( 25422813 )
2014
46
Spindle Cell Lipoma of the Orbit. ( 24819207 )
2014
47
Re: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley. ( 25372424 )
2014
48
Re: co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma. Report of a case. ( 25119179 )
2014
49
Spindle cell lipoma of the mandibular mucogingival junction: a case report of unusual oral neoplasm. ( 24556953 )
2014
50
Spindle cell lipoma of the larynx. ( 23780614 )
2013

Variations for Spindle Cell Lipoma

Expression for Spindle Cell Lipoma

Search GEO for disease gene expression data for Spindle Cell Lipoma.

Pathways for Spindle Cell Lipoma

Pathways related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CDK4 DES FOXO1 MDM2 RB1 VIM
2
Show member pathways
12.69 CDK4 FOXO1 MDM2 RB1
3
Show member pathways
12.57 CDK4 FOXO1 MDM2 RB1
4 12.53 CDK4 FOXO1 MDM2 RB1
5
Show member pathways
12.47 CDK4 FOXO1 MDM2 RB1
6
Show member pathways
12.34 CDK4 MDM2 RB1
7 12.29 ACTC1 DES VIM
8
Show member pathways
12.2 CDK4 DES RB1
9
Show member pathways
12.15 CDK4 MDM2 RB1
10 12.13 CDK4 MDM2 RB1
11 12.09 CDK4 MDM2 RB1 VIM
12 12.06 MDM2 RB1 VIM
13 12.06 CDK4 MDM2 RB1
14
Show member pathways
11.99 CDK4 MDM2 RB1
15 11.92 CDK4 FOXO1 MDM2
16
Show member pathways
11.75 CDK4 RB1 VIM
17 11.73 CDK4 RB1 VIM
18 11.66 CDK4 FOXO1 MDM2 RB1
19 11.59 FOXO1 MDM2 RB1
20 11.55 CDK4 MDM2 RB1
21 11.44 CDK4 MDM2 RB1
22 11.44 CDK4 FOXO1 MDM2 RB1
23 11.41 MDM2 RB1
24 11.4 ACTC1 DES VIM
25 11.39 FOXO1 MDM2
26 11.35 FOXO1 MDM2
27
Show member pathways
11.29 DES VIM
28 11.28 CDK4 MDM2
29 11.19 CDK4 RB1
30 11.12 CDK4 MDM2
31 11.1 CDK4 MDM2 RB1
32 10.97 CDK4 FOXO1 MDM2 RB1
33 10.89 MDM2 RB1

GO Terms for Spindle Cell Lipoma

Biological processes related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.63 ACTC1 MDM2 VIM
2 response to drug GO:0042493 9.5 ACTC1 CDK4 MDM2
3 negative regulation of neuron projection development GO:0010977 9.48 MDM2 VIM
4 cellular response to hydrogen peroxide GO:0070301 9.43 FOXO1 MDM2
5 blood vessel development GO:0001568 9.4 FOXO1 MDM2
6 protein kinase B signaling GO:0043491 9.37 FOXO1 MDM2
7 positive regulation of cell cycle GO:0045787 9.26 CDK4 MDM2
8 negative regulation of cell cycle arrest GO:0071157 9.16 CDK4 MDM2
9 intermediate filament organization GO:0045109 8.96 DES VIM
10 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.46 DES MDM2 RB1 VIM
2 scaffold protein binding GO:0097110 9.26 MDM2 VIM
3 ubiquitin protein ligase binding GO:0031625 9.13 FOXO1 MDM2 RB1
4 disordered domain specific binding GO:0097718 8.62 MDM2 RB1

Sources for Spindle Cell Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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