MCID: SPN006
MIFTS: 30

Spindle Cell Lipoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Lipoma

MalaCards integrated aliases for Spindle Cell Lipoma:

Name: Spindle Cell Lipoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10184
NCIt 49 C4254
SNOMED-CT 67 27313007
UMLS 71 C0334474

Summaries for Spindle Cell Lipoma

Disease Ontology : 12 A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.

MalaCards based summary : Spindle Cell Lipoma is related to pleomorphic lipoma and lipomatosis, multiple. An important gene associated with Spindle Cell Lipoma is CD34 (CD34 Molecule), and among its related pathways/superpathways are Striated Muscle Contraction and Inhibition of Ribosome Biogenesis by p14(ARF). Affiliated tissues include breast, bone and heart, and related phenotypes are Reduced mammosphere formation and cellular

Wikipedia : 74 Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the... more...

Related Diseases for Spindle Cell Lipoma

Diseases related to Spindle Cell Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.8 MDM2 CD34
2 lipomatosis, multiple 30.9 PLAG1 MDM2 DES CD34
3 rare tumor 30.7 DES ACTC1
4 neurofibroma 30.6 VIM CD34 ACTC1
5 familial retinoblastoma 30.4 RB1 MDM2
6 perineurioma 30.4 VIM ACTC1
7 well-differentiated liposarcoma 30.3 PLAG1 MDM2 CD34
8 spindle cell liposarcoma 30.3 MDM2 CD34
9 neurilemmoma 30.3 VIM DES CD34 ACTC1
10 fibrosarcoma 30.2 VIM DES ACTC1
11 congenital fibrosarcoma 30.2 VIM DES ACTC1
12 angiomyolipoma 30.1 VIM DES ACTC1
13 liposarcoma 30.0 VIM RB1 MDM2 DES CD34
14 leiomyoma 30.0 VIM DES CD34 ACTC1
15 lipoblastoma 29.9 PLAG1 MDM2
16 fasciitis 29.8 VIM DES CD34 ACTC1
17 cutaneous fibrous histiocytoma 29.8 VIM DES CD34 ACTC1
18 fibrous histiocytoma 29.8 VIM DES CD34 ACTC1
19 dermatofibrosarcoma protuberans 29.5 VIM DES CD99 CD34 ACTC1
20 angiolipoma 29.5 VIM MDM2 DES CD34 ACTC1
21 dedifferentiated liposarcoma 29.4 RB1 MDM2 DES ACTC1
22 histiocytoma 29.4 VIM MDM2 CD34 ACTC1
23 pleomorphic adenoma 29.2 VIM PLAG1 MDM2 DES ACTC1
24 fibroma 29.2 VIM S100A9 DES CD99 CD34 ACTC1
25 pseudosarcomatous fibromatosis 28.8 VIM NAB2 DES CD34 ACTC1
26 hemangiopericytoma, malignant 27.7 VIM NAB2 MDM2 DES CD99 CD34
27 fibroblastic rheumatism 10.4 DES ACTC1
28 ovarian fibrothecoma 10.4 DES ACTC1
29 myofibroma 10.4 DES CD34
30 infantile digital fibromatosis 10.4 VIM DES
31 primitive neuroectodermal tumor of the cervix uteri 10.4 VIM DES
32 lymphangiomatosis 10.4 VIM DES
33 lymphangiectasis 10.4 VIM ACTC1
34 mesenchymal chondrosarcoma 10.4 VIM DES
35 congenital epulis 10.4 VIM DES
36 epulis 10.4 VIM DES
37 syringocystadenoma papilliferum 10.4 DES ACTC1
38 intravascular papillary endothelial hyperplasia 10.4 VIM ACTC1
39 botryoid rhabdomyosarcoma 10.4 DES ACTC1
40 spindle cell thymoma 10.4 DES CD34
41 angiocentric glioma 10.4 VIM ACTC1
42 non-langerhans-cell histiocytosis 10.3 DES ACTC1
43 granular cell tumor 10.3 VIM DES
44 cervical polyp 10.3 DES CD34
45 desmoplastic small round cell tumor 10.3 VIM DES
46 biphasic synovial sarcoma 10.3 VIM DES
47 retinoblastoma 10.3
48 pyogenic granuloma 10.3 CD34 ACTC1
49 polymorphous low-grade adenocarcinoma 10.3 VIM ACTC1
50 granulosa cell tumor of the ovary 10.3 VIM ACTC1

Graphical network of the top 20 diseases related to Spindle Cell Lipoma:



Diseases related to Spindle Cell Lipoma

Symptoms & Phenotypes for Spindle Cell Lipoma

GenomeRNAi Phenotypes related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CD34 DES MDM2 S100A9 VIM

MGI Mouse Phenotypes related to Spindle Cell Lipoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 ACTC1 CD34 DES MDM2 NAB2 RB1
2 homeostasis/metabolism MP:0005376 9.23 ACTC1 CD34 DES MDM2 NAB2 RB1

Drugs & Therapeutics for Spindle Cell Lipoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Lipoma

Genetic Tests for Spindle Cell Lipoma

Anatomical Context for Spindle Cell Lipoma

MalaCards organs/tissues related to Spindle Cell Lipoma:

40
Breast, Bone, Heart, Tongue, Skin, Adipocyte, Small Intestine

Publications for Spindle Cell Lipoma

Articles related to Spindle Cell Lipoma:

(show top 50) (show all 324)
# Title Authors PMID Year
1
Imaging of spindle cell lipoma. 61
31932047 2020
2
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast. 61
31965112 2019
3
Lipoma arborescens - Uncommon Diagnosis for Joint Swelling: Case Report and Review of the Literature. 61
31746441 2019
4
Spindle Cell Lipomas of the Respiratory Tract: A Case Report and Comprehensive Literature Review. 61
31291740 2019
5
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma With Features Mimicking Spindle Cell Lipoma. 61
31672072 2019
6
Exceptionally large, atypically located spindle cell lipoma. 61
31676502 2019
7
"Low- fat" pseudoangiomatous spindle cell lipoma. 61
31187478 2019
8
Intrathoracic Myxoid Spindle Cell Lipoma, A Rare Presentation of a Myxoid Neoplasm. 61
31589846 2019
9
Spindle Cell Predominant Trichodiscoma or Spindle Cell Lipoma With Adnexal Induction? A Study of 25 Cases, Revealing a Subset of Cases With RB1 Heterozygous Deletion in the Spindle Cell Stroma. 61
30908293 2019
10
Fat-forming variant of solitary fibrous tumor of the pleura, mimicking spindle cell lipoma. 61
30983082 2019
11
Spindle cell lipoma mimicking pleomorphic adenoma: A diagnostic challenge on cytology. 61
30468314 2019
12
A 37 mm Spindle Cell Lipoma on the Floor of the Mouth. 61
31482039 2019
13
Spindle cell lipoma: clinicopathologic characterization of 40 cases. 61
31934089 2019
14
[Primary Orbital Liposarcoma]. 61
30567006 2019
15
Lipoblastoma-like tumor of the vulva: a clinicopathologic, immunohistochemical, fluorescence in situ hybridization and genomic copy number profiling study of seven cases. 61
29976943 2018
16
Utility of STAT6 and 13q14 deletion in the classification of the benign spindle cell stromal tumors of the breast. 61
29940288 2018
17
Dysplastic Lipoma: A Distinctive Atypical Lipomatous Neoplasm With Anisocytosis, Focal Nuclear Atypia, p53 Overexpression, and a Lack of MDM2 Gene Amplification by FISH; A Report of 66 Cases Demonstrating Occasional Multifocality and a Rare Association With Retinoblastoma. 61
30001242 2018
18
Molecular Signature of Tumors with Monoallelic 13q14 Deletion: a Case Series of Spindle Cell Lipoma and Genetically-Related Tumors Demonstrating a Link Between FOXO1 Status and p38 MAPK Pathway. 61
28887603 2018
19
Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10. 61
30303149 2018
20
STAT6 expression in spindle cell lesions of the breast: An immunohistochemical study of 48 cases. 61
30072169 2018
21
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component. 61
29358476 2018
22
[Spindle cell lipoma and pleomorphic lipoma: a clinicopathologic analysis of 65 cases]. 61
29690665 2018
23
Differential Diagnosis of Benign Spindle Cell Lesions. 61
29413661 2018
24
Adipocyte size variability in benign and malignant lipomatous tumors and morphologic mimics: a quantitative definition using digital pathology. 61
29128479 2018
25
Spindle Cell Lipoma of the Thumb. 61
29616170 2018
26
Intrasynovial spindle cell lipoma of the deep flexor of the middle finger causing intermittent carpal tunnel syndrome-case report and review of the literature. 61
29429014 2018
27
Combined classical spindle cell/pleomorphic lipoma spectrum imaging and clinical data. 61
28823067 2018
28
Incidental, low-fat variant of spindle cell lipoma: a novel tumour of the small intestine. 61
29895131 2018
29
Low-fat, plexiform spindle cell lipoma of the lip expressing S100 protein: a neural tumor simulator. 61
29940654 2018
30
[Dendritic infraclavicular fibromyxolipoma: At the boundary between spindle cell lipoma and solitary fibrous tumour]. 61
29290323 2018
31
Cytopathological Diagnosis and Differential Diagnoses of Facial Spindle Cell Lipoma. 61
29403177 2018
32
Pleomorphic fibroma of the skin with MDM2 immunoreactivity: A potential diagnostic pitfall. 61
28981153 2018
33
Exophytic Osteochondroma of the Brow. 61
28614150 2017
34
Chondrolipoma of the breast as a rare variant of myofibroblastoma: an immunohistochemical study of two cases. 61
28653201 2017
35
Intraosseous spindle cell lipoma of the mandible: case report. 61
28735633 2017
36
Spindle Cell Lipoma in Dogs. 61
28494701 2017
37
Anisometric cell lipoma: Insight from a case series and review of the literature on adipocytic neoplasms in survivors of retinoblastoma suggest a role for RB1 loss and possible relationship to fat-predominant ("fat-only") spindle cell lipoma. 61
28807343 2017
38
"Low Fat" Spindle Cell Lipoma of the Eyelid: A Diagnostic Challenge. 61
26017060 2017
39
Cytogenetic Analysis of a Pseudoangiomatous Pleomorphic/Spindle Cell Lipoma. 61
28476785 2017
40
Spindle cell lipoma with prominent Verocay bodies: A potential diagnostic pitfall. 61
28139026 2017
41
Low-Fat Plexiform Spindle Cell Lipoma With Prominent Myxoid Stroma: An Unusual Oral Presentation and Immunohistochemical Analysis. 61
28045832 2017
42
Pseudoangiomatous Spindle Cell Lipoma: a distinct subtype of spindle cell lipoma. 61
27982506 2017
43
Cytohistological Features of Spindle Cell Lipoma- A Case Report with Differential Diagnosis. 61
28384874 2017
44
Loss of chromosome 13 material in cellular angiofibromas indicates pathogenetic similarity with spindle cell lipomas. 61
28193293 2017
45
Atypical Spindle Cell Lipomatous Tumor: Clinicopathologic Characterization of 232 Cases Demonstrating a Morphologic Spectrum. 61
27879515 2017
46
Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature. 61
28123735 2017
47
Spindle Cell Lipoma in an End-Stage Renal Allograft: Case Report. 61
27932168 2016
48
S-100 protein expressing spindle cells in spindle cell lipoma: a diagnostic pitfall. 61
27444171 2016
49
Mammary-Type Myofibroblastoma: A Report of Two Cases. 61
27271111 2016
50
Pseudoangiomatous variant of spindle cell lipoma: Report of a rare case. 61
27510682 2016

Variations for Spindle Cell Lipoma

Expression for Spindle Cell Lipoma

Search GEO for disease gene expression data for Spindle Cell Lipoma.

Pathways for Spindle Cell Lipoma

Pathways related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 VIM DES ACTC1
2 10.3 RB1 MDM2

GO Terms for Spindle Cell Lipoma

Biological processes related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.46 RB1 PLAG1 MDM2 CD34
2 positive regulation of gene expression GO:0010628 9.35 VIM PLAG1 MDM2 CD34 ACTC1
3 tissue homeostasis GO:0001894 9.32 RB1 CD34
4 intermediate filament organization GO:0045109 9.26 VIM DES
5 muscle filament sliding GO:0030049 8.8 VIM DES ACTC1

Molecular functions related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 VIM RB1 NAB2 MDM2 DES
2 disordered domain specific binding GO:0097718 8.96 RB1 MDM2

Sources for Spindle Cell Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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