MCID: SPN017
MIFTS: 31

Spindle Cell Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Liposarcoma

MalaCards integrated aliases for Spindle Cell Liposarcoma:

Name: Spindle Cell Liposarcoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5705
NCIt 50 C27489
UMLS 73 C1275275

Summaries for Spindle Cell Liposarcoma

MalaCards based summary : Spindle Cell Liposarcoma is related to spindle cell lipoma and liposarcoma. An important gene associated with Spindle Cell Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Hematopoietic cell lineage and C-MYB transcription factor network. Affiliated tissues include liver, bone and ovary, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Spindle Cell Liposarcoma

Diseases related to Spindle Cell Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 spindle cell lipoma 30.4 CDK4 MDM2
2 liposarcoma 30.3 CALB2 CD34 CDK4 DDIT3 MDM2
3 atypical lipomatous tumor 30.3 CDK4 MDM2 SMARCB1
4 mesenchymoma 10.3 MDM2 MYOD1
5 ring chromosome 7 10.3 CDK4 MDM2
6 retroperitoneal sarcoma 10.3 MDM2 SMARCB1
7 cellular myxoid liposarcoma 10.3 CDK4 MDM2
8 inflammatory mfh 10.3 CDK4 MDM2
9 prostate embryonal rhabdomyosarcoma 10.3 KIT MYOD1
10 lipoblastoma 10.2 CDK4 MDM2
11 bone osteosarcoma 10.2 CDK4 MDM2
12 angiokeratoma of fordyce 10.2 HBA1 WT1
13 testicular gonadoblastoma 10.2 KIT WT1
14 prostate rhabdomyosarcoma 10.2 KIT MYOD1
15 benign mesothelioma 10.2 HBA1 WT1
16 langerhans cell sarcoma 10.2 CR2 HBA1
17 kidney rhabdoid cancer 10.2 SMARCB1 WT1
18 periosteal chondrosarcoma 10.2 CDK4 MDM2
19 malignant fibrous histiocytoma of bone 10.2 CDK4 MDM2 MYOD1
20 malignant fibroxanthoma 10.2 CDK4 MDM2 MYOD1
21 esophagus sarcoma 10.2 CREB3L2 KIT
22 skin epithelioid hemangioma 10.2 CD34 HBA1
23 ovary sarcoma 10.2 CD34 HBA1
24 ovarian angiosarcoma 10.2 CD34 HBA1
25 liver inflammatory pseudotumor 10.2 CD34 CR2
26 histiocytoma 10.2 KIT MDM2 MYOD1
27 intravascular fasciitis 10.2 CD34 HBA1
28 breast rhabdomyosarcoma 10.2 MYOD1 MYOG
29 gallbladder leiomyoma 10.2 CD34 KIT
30 lung leiomyosarcoma 10.2 CD34 KIT
31 pediatric angiosarcoma 10.2 CD34 HBA1
32 thyroid angiosarcoma 10.2 CD34 HBA1
33 rhabdoid cancer 10.2 MYOD1 SMARCB1 WT1
34 spleen angiosarcoma 10.2 CD34 HBA1
35 liver leiomyoma 10.2 CD34 KIT
36 hypereosinophilic syndrome, idiopathic 10.2 KIT WT1
37 bone epithelioid hemangioma 10.2 CD34 HBA1
38 rhabdoid tumor predisposition syndrome 1 10.2 MYOD1 SMARCB1 WT1
39 deep leiomyoma 10.2 CD34 KIT
40 thyroid sarcoma 10.2 CD34 HBA1
41 extracutaneous mastocytoma 10.2 CD34 KIT
42 small intestine leiomyosarcoma 10.2 CD34 KIT
43 hordeolum 10.2 CD34 HBA1
44 vulvar sarcoma 10.2 CD34 SMARCB1
45 small intestinal sarcoma 10.2 CD34 KIT
46 cystic nephroma 10.2 KIT WT1
47 glomeruloid hemangioma 10.2 CD34 HBA1
48 hemangioma of liver 10.2 CD34 HBA1
49 prostate leiomyosarcoma 10.2 CD34 KIT
50 well-differentiated liposarcoma 10.2 CDK4 MDM2

Graphical network of the top 20 diseases related to Spindle Cell Liposarcoma:



Diseases related to Spindle Cell Liposarcoma

Symptoms & Phenotypes for Spindle Cell Liposarcoma

GenomeRNAi Phenotypes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD34 CDK4 DDIT3 MDM2 SMARCB1 TLE1

MGI Mouse Phenotypes related to Spindle Cell Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CD34 CDK4 CR2 DDIT3 KIT MDM2
2 liver/biliary system MP:0005370 9.8 CDK4 DDIT3 KIT MDM2 SMARCB1 WT1
3 muscle MP:0005369 9.8 CDK4 KIT MDM2 MYOD1 MYOG SMARCB1
4 neoplasm MP:0002006 9.76 CD34 CDK4 DDIT3 KIT MDM2 MYOD1
5 no phenotypic analysis MP:0003012 9.43 KIT MDM2 MLANA MYOD1 MYOG WT1
6 normal MP:0002873 9.17 CALB2 CDK4 KIT MDM2 MYOD1 MYOG

Drugs & Therapeutics for Spindle Cell Liposarcoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Liposarcoma

Genetic Tests for Spindle Cell Liposarcoma

Anatomical Context for Spindle Cell Liposarcoma

MalaCards organs/tissues related to Spindle Cell Liposarcoma:

41
Liver, Bone, Ovary, Spleen, Prostate, Thyroid, Testis

Publications for Spindle Cell Liposarcoma

Articles related to Spindle Cell Liposarcoma:

(show all 11)
# Title Authors Year
1
A large well-differentiated spindle cell liposarcoma (atypical spindle cell lipomatous tumor): clinicopathologic and immunohistochemical analysis Diagnostic and therapeutic features. ( 25624426 )
2014
2
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. ( 23413865 )
2013
3
Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas. ( 23887155 )
2013
4
Spindle cell liposarcoma of the face: case report and literature review. ( 20456346 )
2010
5
Giant oesophageal liposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation. ( 20418237 )
2010
6
Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. ( 20228779 )
2010
7
Primary retroperitoneal spindle cell liposarcoma: pathological and immunohistochemical findings. ( 20518903 )
2010
8
Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. ( 15719245 )
2005
9
Spindle-cell liposarcoma: a rare variant of liposarcoma arising in the foot. ( 15830579 )
2005
10
Images in pathology: multiple cytoplasmic vacuoles in a spindle cell liposarcoma. ( 12232576 )
2002
11
Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. ( 8067512 )
1994

Variations for Spindle Cell Liposarcoma

Expression for Spindle Cell Liposarcoma

Search GEO for disease gene expression data for Spindle Cell Liposarcoma.

Pathways for Spindle Cell Liposarcoma

Pathways related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 CD34 CR2 KIT
2 11.22 CD34 KIT MYOD1
3 10.88 MDM2 MYOD1 SMARCB1
4 10.52 CD34 CR2 KIT

GO Terms for Spindle Cell Liposarcoma

Cellular components related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.61 CDK4 CREB3L2 DDIT3 MDM2 MYOD1 MYOG
2 transcription factor complex GO:0005667 8.92 CDK4 MYOD1 MYOG TLE1

Biological processes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 CREB3L2 DDIT3 MYOD1 MYOG SMARCB1 WT1
2 positive regulation of transcription, DNA-templated GO:0045893 9.65 CREB3L2 DDIT3 MYOD1 MYOG WT1
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.58 DDIT3 KIT SMARCB1
4 skeletal muscle fiber development GO:0048741 9.52 MYOD1 MYOG
5 negative regulation of cell cycle arrest GO:0071157 9.51 CDK4 MDM2
6 positive regulation of myoblast differentiation GO:0045663 9.49 MYOD1 MYOG
7 myoblast differentiation GO:0045445 9.48 MYOD1 MYOG
8 mRNA transcription by RNA polymerase II GO:0042789 9.46 DDIT3 MYOG
9 positive regulation of myoblast fusion GO:1901741 9.43 MYOD1 MYOG
10 myotube differentiation GO:0014902 9.37 MYOD1 MYOG
11 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYOD1 MYOG
12 positive regulation of gene expression GO:0010628 9.1 CD34 CREB3L2 KIT MDM2 TLE1 WT1
13 muscle cell fate commitment GO:0042693 8.96 MYOD1 MYOG

Molecular functions related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.56 CD34 DDIT3 MYOD1 TLE1
2 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.46 CREB3L2 DDIT3 MYOG WT1
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.35 CREB3L2 DDIT3 MYOD1 MYOG SMARCB1
4 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.92 CREB3L2 MYOD1 MYOG WT1

Sources for Spindle Cell Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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