MCID: SPN017
MIFTS: 26

Spindle Cell Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Liposarcoma

MalaCards integrated aliases for Spindle Cell Liposarcoma:

Name: Spindle Cell Liposarcoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5705
NCIt 49 C27489
UMLS 71 C1275275

Summaries for Spindle Cell Liposarcoma

MalaCards based summary : Spindle Cell Liposarcoma is related to spindle cell lipoma and sclerosing liposarcoma. An important gene associated with Spindle Cell Liposarcoma is CD34 (CD34 Molecule), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and Bladder cancer. Affiliated tissues include heart, breast and bone, and related phenotypes are Reduced mammosphere formation and neoplasm

Related Diseases for Spindle Cell Liposarcoma

Diseases related to Spindle Cell Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 spindle cell lipoma 30.7 MDM2 CD34
2 sclerosing liposarcoma 30.3 MDM2 CD34
3 liposarcoma 29.7 MDM2 DDIT3 CDK4 CD34
4 malignant peripheral nerve sheath tumor 29.7 MDM2 CDK4 CD34
5 pleomorphic lipoma 29.5 UBE2D1 MDM2 CDK4 CD34
6 well-differentiated liposarcoma 29.4 MDM2 DDIT3 CDK4 CD34
7 dedifferentiated liposarcoma 29.3 MDM2 DDIT3 CDK4
8 myxoid liposarcoma 29.3 MDM2 DDIT3 CDK4
9 lipomatosis, multiple 28.7 MDM2 HMGA1 DDIT3 CDK4 CD34
10 angiolipoma 10.3 MDM2 CD34
11 aortic malignant tumor 10.2 MDM2 CD34
12 heart leiomyosarcoma 10.2 MDM2 CD34
13 inflammatory liposarcoma 10.2 MDM2 CD34
14 heart sarcoma 10.2 MDM2 CD34
15 malignant mesenchymoma 10.2 MDM2 CD34
16 mesenchymoma 10.2 MDM2 CD34
17 spindle cell synovial sarcoma 10.2 TLE1 CD34
18 ring chromosome 7 10.1 MDM2 CDK4
19 mediastinum liposarcoma 10.1 MDM2 CDK4
20 conventional fibrosarcoma 10.1 MDM2 CD34
21 diffuse lipomatosis 10.1 MDM2 CDK4
22 undifferentiated embryonal sarcoma of the liver 10.1 MDM2 CDK4
23 embryonal sarcoma 10.1 MDM2 CDK4
24 myxofibrosarcoma 10.1
25 rare tumor 10.1
26 infiltrating lipoma 10.1 MDM2 CDK4
27 subungual glomus tumor 10.1 TLE1 CD34
28 heart cancer 10.1 MDM2 CD34
29 glomus tumor 10.1 TLE1 CD34
30 lipoblastoma 10.1 MDM2 CDK4
31 mediastinum sarcoma 10.1 MDM2 CDK4
32 inflammatory mfh 10.1 MDM2 CDK4
33 adult liposarcoma 10.1 MDM2 CDK4
34 juxtacortical osteosarcoma 10.1 MDM2 CDK4
35 nasal cavity neoplasm 10.1 UBE2D1 CD34
36 paratesticular lipoma 10.1 MDM2 CDK4
37 parasagittal meningioma 10.1 UBE2D1 CD34
38 lipoma of spermatic cord 10.1 MDM2 CDK4
39 angiomatous meningioma 10.1 UBE2D1 CD34
40 monophasic synovial sarcoma 10.1 TLE1 CD34
41 cerebral convexity meningioma 10.1 UBE2D1 CD34
42 peripheral osteosarcoma 10.1 MDM2 CDK4
43 spindle cell thymoma 10.1 UBE2D1 CD34
44 meninges hemangiopericytoma 10.1 UBE2D1 CD34
45 spindle cell sarcoma 10.1 MDM2 CD34
46 secondary hypertrophic osteoarthropathy 10.1 UBE2D1 CD34
47 parameningeal embryonal rhabdomyosarcoma 10.1 MDM2 CDK4
48 follicular dendritic cell sarcoma 10.0 MDM2 CD34
49 embryonal rhabdomyosarcoma 10.0 MDM2 CDK4
50 pelvic lipomatosis 10.0 HMGA1 CD34

Graphical network of the top 20 diseases related to Spindle Cell Liposarcoma:



Diseases related to Spindle Cell Liposarcoma

Symptoms & Phenotypes for Spindle Cell Liposarcoma

GenomeRNAi Phenotypes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CD34 CDK4 DDIT3 MDM2 TLE1

MGI Mouse Phenotypes related to Spindle Cell Liposarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CD34 CDK4 DDIT3 MDM2

Drugs & Therapeutics for Spindle Cell Liposarcoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Liposarcoma

Genetic Tests for Spindle Cell Liposarcoma

Anatomical Context for Spindle Cell Liposarcoma

MalaCards organs/tissues related to Spindle Cell Liposarcoma:

40
Heart, Breast, Bone, Ovary, Adipocyte, Skin, Skeletal Muscle

Publications for Spindle Cell Liposarcoma

Articles related to Spindle Cell Liposarcoma:

(show all 29)
# Title Authors PMID Year
1
Spindle cell liposarcoma with a TRIO-TERT fusion transcript. 61
30793229 2019
2
Lipomatous angiomyofibroblastoma of the vulva: diagnostic and histogenetic considerations. 61
25845047 2014
3
A large well-differentiated spindle cell liposarcoma (atypical spindle cell lipomatous tumor): clinicopathologic and immunohistochemical analysis. Diagnostic and therapeutic features. 61
25624426 2014
4
Recently characterized soft tissue tumors that bring biologic insight. 61
24384856 2014
5
Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas. 61
23887155 2013
6
Dedifferentiated liposarcoma with lipoma-like well-differentiated liposarcoma: clinicopathological study of 30 cases, with particular attention to the comingling pattern of well- and dedifferentiated components: a proposal for regrouping of the present subclassification of well-differentiated liposarcoma and dedifferentiated liposarcoma. 61
22674916 2013
7
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. 61
23413865 2013
8
[Molecular methods in the diagnosis of sarcoma]. 61
20978765 2011
9
Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. 61
20829680 2010
10
Spindle cell liposarcoma of the face: case report and literature review. 61
20456346 2010
11
Primary retroperitoneal spindle cell liposarcoma: pathological and immunohistochemical findings. 61
20518903 2010
12
Giant oesophageal liposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation. 61
20418237 2010
13
Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. 61
20228779 2010
14
Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas. 61
18617058 2008
15
Spindle-cell liposarcoma: a rare variant of liposarcoma arising in the foot. 61
15830579 2005
16
Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. 61
15719245 2005
17
[Recent entities in soft tissue tumor pathology. Part 2]. 61
12843968 2003
18
Liposarcoma metastatic to the orbit. 61
12635688 2003
19
Images in pathology: multiple cytoplasmic vacuoles in a spindle cell liposarcoma. 61
12232576 2002
20
Newly described adipocytic lesions. 61
11757863 2001
21
Well-differentiated liposarcoma (atypical lipomatous tumors). 61
11757865 2001
22
Lipomatous myofibroblastoma: a potential diagnostic pitfall in the spectrum of the spindle cell lesions of the breast. 61
11147176 2000
23
[Lipomatous tumors of the skin and soft tissue. New entities and concepts]. 61
11148824 2000
24
Liposarcoma: new entities and evolving concepts. 61
10982304 2000
25
Multiple spindle cell lipomas: a report of 7 familial and 11 nonfamilial cases. 61
9422314 1998
26
Lipoleiomyosarcoma of the mediastinum. 61
9423230 1997
27
Recent developments in soft tissue tumors. 61
8835259 1995
28
Lipomatous tumours of soft tissues: an update. 61
8548119 1995
29
Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. 61
8067512 1994

Variations for Spindle Cell Liposarcoma

Expression for Spindle Cell Liposarcoma

Search GEO for disease gene expression data for Spindle Cell Liposarcoma.

Pathways for Spindle Cell Liposarcoma

GO Terms for Spindle Cell Liposarcoma

Cellular components related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.43 UBE2D1 TLE1 MDM2 HMGA1 DDIT3 CDK4
2 transcription factor complex GO:0005667 8.8 TLE1 HMGA1 CDK4

Biological processes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle GO:0045787 9.16 MDM2 CDK4
2 negative regulation of cell cycle arrest GO:0071157 8.96 MDM2 CDK4
3 negative regulation of transcription, DNA-templated GO:0045892 8.92 TLE1 MDM2 HMGA1 DDIT3

Molecular functions related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome proliferator activated receptor binding GO:0042975 8.96 MDM2 HMGA1
2 transcription factor binding GO:0008134 8.92 TLE1 HMGA1 DDIT3 CD34

Sources for Spindle Cell Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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