MCID: SPN017
MIFTS: 29

Spindle Cell Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Liposarcoma

MalaCards integrated aliases for Spindle Cell Liposarcoma:

Name: Spindle Cell Liposarcoma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5705
NCIt 50 C27489
UMLS 72 C1275275

Summaries for Spindle Cell Liposarcoma

MalaCards based summary : Spindle Cell Liposarcoma is related to spindle cell lipoma and well-differentiated liposarcoma. An important gene associated with Spindle Cell Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Validated targets of C-MYC transcriptional activation and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Affiliated tissues include skin, breast and adipocyte, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Spindle Cell Liposarcoma

Diseases related to Spindle Cell Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 spindle cell lipoma 31.4 MDM2 CDK4
2 well-differentiated liposarcoma 31.4 MDM2 CDK4
3 lipomatosis, multiple 31.2 MDM2 HMGA1 CDK4
4 dedifferentiated liposarcoma 30.7 MDM2 CDK4
5 sclerosing liposarcoma 30.7 MDM2 CD34
6 soft tissue sarcoma 30.6 TERT MDM2
7 malignant peripheral nerve sheath tumor 30.6 SMARCB1 MDM2 CDK4
8 myxoid liposarcoma 30.3 MDM2 DDIT3 CDK4
9 rhabdomyosarcoma 29.8 MYOG MYOD1 MDM2 CDK4
10 leiomyosarcoma 29.7 WT1 MYOG MDM2 CDK4
11 liposarcoma 29.4 MDM2 DDIT3 CDK4 CD34 CALB2
12 mesenchymoma 10.7 MYOD1 MDM2
13 ring chromosome 7 10.7 MDM2 CDK4
14 inflammatory mfh 10.7 MDM2 CDK4
15 cellular myxoid liposarcoma 10.7 MDM2 CDK4
16 lipoblastoma 10.6 MDM2 CDK4
17 retroperitoneal sarcoma 10.6 SMARCB1 MDM2
18 bone osteosarcoma 10.6 MDM2 CDK4
19 periosteal chondrosarcoma 10.6 MDM2 CDK4
20 kidney rhabdoid cancer 10.5 WT1 SMARCB1
21 malignant fibrous histiocytoma of bone 10.5 MYOD1 MDM2 CDK4
22 malignant fibroxanthoma 10.5 MYOD1 MDM2 CDK4
23 heart sarcoma 10.4 WT1 MDM2
24 conventional fibrosarcoma 10.4 MDM2 CD34
25 liver inflammatory pseudotumor 10.4 CR2 CD34
26 inflammatory myofibroblastic tumor 10.4 MDM2 CR2 CDK4
27 spleen cancer 10.4 CR2 CD34
28 kidney clear cell sarcoma 10.4 WT1 TERT
29 hobnail hemangioma 10.4 WT1 CD34
30 vulvar sarcoma 10.4 SMARCB1 CD34
31 synovium cancer 10.4 TLE1 SMARCB1
32 uterine sarcoma 10.3 WT1 SMARCB1 MDM2
33 kaposiform hemangioendothelioma 10.3 PECAM1 CD34
34 rhabdoid cancer 10.3 WT1 SMARCB1 MYOD1
35 breast rhabdomyosarcoma 10.3 MYOG MYOD1
36 rhabdoid tumor predisposition syndrome 1 10.3 WT1 SMARCB1 MYOD1
37 ischemic fasciitis 10.3 MDM2 CDK4 CD34
38 periosteal osteogenic sarcoma 10.3 MDM2 CDK4 CD34
39 infiltrating lipoma 10.3 MDM2 CDK4 CD34
40 pleomorphic lipoma 10.3
41 erythema elevatum diutinum 10.3 PECAM1 CD34
42 inflammatory leiomyosarcoma 10.3 MYOG MYOD1
43 epithelioid cell melanoma 10.3 WT1 MLANA
44 infiltrating angiolipoma 10.2 MLANA MDM2 CDK4
45 conventional leiomyosarcoma 10.2 MYOG MYOD1
46 chondroid lipoma 10.2 MDM2 DDIT3 CDK4
47 mesenchymal cell neoplasm 10.2 SMARCB1 CD34
48 breast angiosarcoma 10.1 MLANA CD34
49 myxofibrosarcoma 10.1
50 rare tumor 10.1

Graphical network of the top 20 diseases related to Spindle Cell Liposarcoma:



Diseases related to Spindle Cell Liposarcoma

Symptoms & Phenotypes for Spindle Cell Liposarcoma

GenomeRNAi Phenotypes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD34 CDK4 DDIT3 MDM2 SMARCB1 TLE1

MGI Mouse Phenotypes related to Spindle Cell Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 CD34 CDK4 CR2 DDIT3 MDM2 MYOD1
2 hematopoietic system MP:0005397 10.06 CD34 CDK4 CR2 DDIT3 MDM2 PECAM1
3 immune system MP:0005387 9.97 CD34 CDK4 CR2 DDIT3 MDM2 PECAM1
4 liver/biliary system MP:0005370 9.73 CDK4 DDIT3 MDM2 PECAM1 SMARCB1 WT1
5 muscle MP:0005369 9.7 CDK4 MDM2 MYOD1 MYOG PECAM1 SMARCB1
6 neoplasm MP:0002006 9.56 CD34 CDK4 DDIT3 MDM2 MYOD1 SMARCB1
7 normal MP:0002873 9.17 CALB2 CDK4 MDM2 MYOD1 MYOG TERT

Drugs & Therapeutics for Spindle Cell Liposarcoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Liposarcoma

Genetic Tests for Spindle Cell Liposarcoma

Anatomical Context for Spindle Cell Liposarcoma

MalaCards organs/tissues related to Spindle Cell Liposarcoma:

41
Skin, Breast, Adipocyte

Publications for Spindle Cell Liposarcoma

Articles related to Spindle Cell Liposarcoma:

(show all 29)
# Title Authors PMID Year
1
Spindle cell liposarcoma with a TRIO-TERT fusion transcript. 38
30793229 2019
2
Lipomatous angiomyofibroblastoma of the vulva: diagnostic and histogenetic considerations. 38
25845047 2014
3
A large well-differentiated spindle cell liposarcoma (atypical spindle cell lipomatous tumor): clinicopathologic and immunohistochemical analysis. Diagnostic and therapeutic features. 38
25624426 2014
4
Recently characterized soft tissue tumors that bring biologic insight. 38
24384856 2014
5
Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas. 38
23887155 2013
6
Dedifferentiated liposarcoma with lipoma-like well-differentiated liposarcoma: clinicopathological study of 30 cases, with particular attention to the comingling pattern of well- and dedifferentiated components: a proposal for regrouping of the present subclassification of well-differentiated liposarcoma and dedifferentiated liposarcoma. 38
22674916 2013
7
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. 38
23413865 2013
8
[Molecular methods in the diagnosis of sarcoma]. 38
20978765 2011
9
Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period. 38
20829680 2010
10
Spindle cell liposarcoma of the face: case report and literature review. 38
20456346 2010
11
Primary retroperitoneal spindle cell liposarcoma: pathological and immunohistochemical findings. 38
20518903 2010
12
Giant oesophageal liposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation. 38
20418237 2010
13
Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. 38
20228779 2010
14
Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas. 38
18617058 2008
15
Spindle-cell liposarcoma: a rare variant of liposarcoma arising in the foot. 38
15830579 2005
16
Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. 38
15719245 2005
17
[Recent entities in soft tissue tumor pathology. Part 2]. 38
12843968 2003
18
Liposarcoma metastatic to the orbit. 38
12635688 2003
19
Images in pathology: multiple cytoplasmic vacuoles in a spindle cell liposarcoma. 38
12232576 2002
20
Newly described adipocytic lesions. 38
11757863 2001
21
Well-differentiated liposarcoma (atypical lipomatous tumors). 38
11757865 2001
22
Lipomatous myofibroblastoma: a potential diagnostic pitfall in the spectrum of the spindle cell lesions of the breast. 38
11147176 2000
23
[Lipomatous tumors of the skin and soft tissue. New entities and concepts]. 38
11148824 2000
24
Liposarcoma: new entities and evolving concepts. 38
10982304 2000
25
Multiple spindle cell lipomas: a report of 7 familial and 11 nonfamilial cases. 38
9422314 1998
26
Lipoleiomyosarcoma of the mediastinum. 38
9423230 1997
27
Recent developments in soft tissue tumors. 38
8835259 1995
28
Lipomatous tumours of soft tissues: an update. 38
8548119 1995
29
Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. 38
8067512 1994

Variations for Spindle Cell Liposarcoma

Expression for Spindle Cell Liposarcoma

Search GEO for disease gene expression data for Spindle Cell Liposarcoma.

Pathways for Spindle Cell Liposarcoma

Pathways related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.24 TERT HMGA1 CDK4
2 11.03 TLE1 TERT MYOG
3 10.55 SMARCB1 MYOD1 MDM2

GO Terms for Spindle Cell Liposarcoma

Cellular components related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.9 WT1 TLE1 TERT SMARCB1 MYOG MYOD1
2 nucleoplasm GO:0005654 9.65 WT1 TLE1 TERT SMARCB1 MYOG MYOD1
3 transcription factor complex GO:0005667 9.02 TLE1 MYOG MYOD1 HMGA1 CDK4

Biological processes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.87 WT1 SMARCB1 MYOG HMGA1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 WT1 SMARCB1 MYOG MYOD1 HMGA1 DDIT3
3 positive regulation of gene expression GO:0010628 9.84 WT1 TLE1 MDM2 CD34
4 positive regulation of transcription, DNA-templated GO:0045893 9.72 WT1 MYOG MYOD1 HMGA1 DDIT3
5 negative regulation of transcription, DNA-templated GO:0045892 9.65 WT1 TLE1 MDM2 HMGA1 DDIT3
6 beta-catenin-TCF complex assembly GO:1904837 9.59 TLE1 TERT
7 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.58 WT1 TERT
8 positive regulation of muscle cell differentiation GO:0051149 9.58 MYOG MYOD1
9 skeletal muscle fiber development GO:0048741 9.56 MYOG MYOD1
10 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.55 TERT MDM2
11 negative regulation of cell cycle arrest GO:0071157 9.52 MDM2 CDK4
12 positive regulation of myoblast differentiation GO:0045663 9.51 MYOG MYOD1
13 myoblast differentiation GO:0045445 9.49 MYOG MYOD1
14 nucleosome disassembly GO:0006337 9.48 SMARCB1 HMGA1
15 mRNA transcription by RNA polymerase II GO:0042789 9.46 MYOG DDIT3
16 positive regulation of myoblast fusion GO:1901741 9.43 MYOG MYOD1
17 myotube differentiation GO:0014902 9.4 MYOG MYOD1
18 positive regulation of skeletal muscle fiber development GO:0048743 9.16 MYOG MYOD1
19 muscle cell fate commitment GO:0042693 8.96 MYOG MYOD1
20 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Molecular functions related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.56 WT1 TERT SMARCB1 MYOG MYOD1 HMGA1
2 peroxisome proliferator activated receptor binding GO:0042975 9.16 MDM2 HMGA1
3 transcription factor binding GO:0008134 9.02 TLE1 MYOD1 HMGA1 DDIT3 CD34
4 protein binding GO:0005515 10.07 WT1 TLE1 TERT SMARCB1 PECAM1 MYOG

Sources for Spindle Cell Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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