MCID: SPN017
MIFTS: 29

Spindle Cell Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Liposarcoma

MalaCards integrated aliases for Spindle Cell Liposarcoma:

Name: Spindle Cell Liposarcoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5705
NCIt 51 C27489
UMLS 74 C1275275

Summaries for Spindle Cell Liposarcoma

MalaCards based summary : Spindle Cell Liposarcoma is related to spindle cell lipoma and atypical lipomatous tumor. An important gene associated with Spindle Cell Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic cell lineage. Related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Spindle Cell Liposarcoma

Diseases related to Spindle Cell Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 spindle cell lipoma 30.6 CDK4 MDM2
2 atypical lipomatous tumor 30.4 CDK4 MDM2 SMARCB1
3 liposarcoma 29.9 CALB2 CD34 CDK4 DDIT3 MDM2
4 mesenchymoma 10.5 MDM2 MYOD1
5 ring chromosome 7 10.4 CDK4 MDM2
6 cellular myxoid liposarcoma 10.4 CDK4 MDM2
7 inflammatory mfh 10.4 CDK4 MDM2
8 retroperitoneal sarcoma 10.4 MDM2 SMARCB1
9 lipoblastoma 10.4 CDK4 MDM2
10 bone osteosarcoma 10.4 CDK4 MDM2
11 prostate embryonal rhabdomyosarcoma 10.4 KIT MYOD1
12 periosteal chondrosarcoma 10.4 CDK4 MDM2
13 prostate rhabdomyosarcoma 10.3 KIT MYOD1
14 kidney rhabdoid cancer 10.3 SMARCB1 WT1
15 malignant fibrous histiocytoma of bone 10.3 CDK4 MDM2 MYOD1
16 testicular gonadoblastoma 10.3 KIT WT1
17 malignant fibroxanthoma 10.3 CDK4 MDM2 MYOD1
18 sclerosing liposarcoma 10.3 CD34 MDM2
19 well-differentiated liposarcoma 10.3 CDK4 MDM2
20 liver inflammatory pseudotumor 10.3 CD34 CR2
21 spleen cancer 10.3 CD34 CR2
22 acral lentiginous melanoma 10.3 KIT TERT
23 breast rhabdomyosarcoma 10.3 MYOD1 MYOG
24 vulvar sarcoma 10.3 CD34 SMARCB1
25 hobnail hemangioma 10.3 CD34 WT1
26 gallbladder leiomyoma 10.3 CD34 KIT
27 hypereosinophilic syndrome, idiopathic 10.3 KIT WT1
28 lung leiomyosarcoma 10.3 CD34 KIT
29 histiocytoma 10.2 KIT MDM2 MYOD1
30 liver leiomyoma 10.2 CD34 KIT
31 rhabdoid cancer 10.2 MYOD1 SMARCB1 WT1
32 fibrosarcoma of bone 10.2 CDK4 KIT MDM2
33 deep leiomyoma 10.2 CD34 KIT
34 cystic nephroma 10.2 KIT WT1
35 rhabdoid tumor predisposition syndrome 1 10.2 MYOD1 SMARCB1 WT1
36 pulmonary vein stenosis 10.2 KIT PECAM1
37 extracutaneous mastocytoma 10.2 CD34 KIT
38 small intestine leiomyosarcoma 10.2 CD34 KIT
39 small intestinal sarcoma 10.2 CD34 KIT
40 inflammatory leiomyosarcoma 10.2 MYOD1 MYOG
41 kidney clear cell sarcoma 10.2 TERT WT1
42 kaposiform hemangioendothelioma 10.2 CD34 PECAM1
43 prostate leiomyosarcoma 10.2 CD34 KIT
44 conventional leiomyosarcoma 10.2 MYOD1 MYOG
45 synovium cancer 10.2 SMARCB1 TLE1
46 heart sarcoma 10.2 KIT MDM2 WT1
47 periosteal osteogenic sarcoma 10.2 CD34 CDK4 MDM2
48 plexiform schwannoma 10.2 CD34 KIT
49 ischemic fasciitis 10.2 CD34 CDK4 MDM2
50 infiltrating lipoma 10.2 CD34 CDK4 MDM2

Graphical network of the top 20 diseases related to Spindle Cell Liposarcoma:



Diseases related to Spindle Cell Liposarcoma

Symptoms & Phenotypes for Spindle Cell Liposarcoma

GenomeRNAi Phenotypes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD34 CDK4 DDIT3 MDM2 SMARCB1 TLE1

MGI Mouse Phenotypes related to Spindle Cell Liposarcoma:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.23 CD34 CDK4 CR2 DDIT3 KIT MDM2
2 hematopoietic system MP:0005397 10.18 CD34 CDK4 CR2 DDIT3 KIT MDM2
3 cellular MP:0005384 10.16 CD34 CDK4 DDIT3 KIT MDM2 PECAM1
4 cardiovascular system MP:0005385 10.13 CDK4 DDIT3 KIT MDM2 MYOD1 PECAM1
5 immune system MP:0005387 10.13 CD34 CDK4 CR2 DDIT3 KIT MDM2
6 digestive/alimentary MP:0005381 9.97 CDK4 KIT MDM2 PECAM1 SMARCB1 TERT
7 muscle MP:0005369 9.97 CDK4 KIT MDM2 MYOD1 MYOG PECAM1
8 neoplasm MP:0002006 9.97 CD34 CDK4 DDIT3 KIT MDM2 MYOD1
9 liver/biliary system MP:0005370 9.95 CDK4 DDIT3 KIT MDM2 PECAM1 SMARCB1
10 normal MP:0002873 9.76 CALB2 CDK4 KIT MDM2 MYOD1 MYOG
11 no phenotypic analysis MP:0003012 9.73 KIT MDM2 MLANA MYOD1 MYOG WT1
12 renal/urinary system MP:0005367 9.43 CDK4 CR2 KIT MDM2 PECAM1 WT1
13 respiratory system MP:0005388 9.1 KIT MYOD1 MYOG PECAM1 TERT WT1

Drugs & Therapeutics for Spindle Cell Liposarcoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Liposarcoma

Genetic Tests for Spindle Cell Liposarcoma

Anatomical Context for Spindle Cell Liposarcoma

Publications for Spindle Cell Liposarcoma

Articles related to Spindle Cell Liposarcoma:

(show all 12)
# Title Authors Year
1
Spindle cell liposarcoma with a TRIO-TERT fusion transcript. ( 30793229 )
2019
2
A large well-differentiated spindle cell liposarcoma (atypical spindle cell lipomatous tumor): clinicopathologic and immunohistochemical analysis Diagnostic and therapeutic features. ( 25624426 )
2014
3
Palmar well differentiated spindle cell liposarcoma: presentation of a rare tumor at a rare site. ( 23413865 )
2013
4
Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas. ( 23887155 )
2013
5
Spindle cell liposarcoma of the face: case report and literature review. ( 20456346 )
2010
6
Giant oesophageal liposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation. ( 20418237 )
2010
7
Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. ( 20228779 )
2010
8
Primary retroperitoneal spindle cell liposarcoma: pathological and immunohistochemical findings. ( 20518903 )
2010
9
Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. ( 15719245 )
2005
10
Spindle-cell liposarcoma: a rare variant of liposarcoma arising in the foot. ( 15830579 )
2005
11
Images in pathology: multiple cytoplasmic vacuoles in a spindle cell liposarcoma. ( 12232576 )
2002
12
Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. ( 8067512 )
1994

Variations for Spindle Cell Liposarcoma

Expression for Spindle Cell Liposarcoma

Search GEO for disease gene expression data for Spindle Cell Liposarcoma.

Pathways for Spindle Cell Liposarcoma

Pathways related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.18 CD34 KIT MLANA PECAM1
2 11.48 CD34 CR2 KIT
3 11.33 MYOG TERT TLE1
4 11.22 CD34 KIT MYOD1
5 10.88 MDM2 MYOD1 SMARCB1
6 10.52 CD34 CR2 KIT

GO Terms for Spindle Cell Liposarcoma

Cellular components related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.61 CDK4 DDIT3 MDM2 MYOD1 MYOG SMARCB1
2 transcription factor complex GO:0005667 8.92 CDK4 MYOD1 MYOG TLE1

Biological processes related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.54 DDIT3 KIT SMARCB1
2 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.52 MDM2 TERT
3 skeletal muscle fiber development GO:0048741 9.51 MYOD1 MYOG
4 negative regulation of cell cycle arrest GO:0071157 9.49 CDK4 MDM2
5 positive regulation of myoblast differentiation GO:0045663 9.48 MYOD1 MYOG
6 myoblast differentiation GO:0045445 9.46 MYOD1 MYOG
7 mRNA transcription by RNA polymerase II GO:0042789 9.43 DDIT3 MYOG
8 positive regulation of myoblast fusion GO:1901741 9.4 MYOD1 MYOG
9 positive regulation of gene expression GO:0010628 9.35 CD34 KIT MDM2 TLE1 WT1
10 myotube differentiation GO:0014902 9.32 MYOD1 MYOG
11 positive regulation of skeletal muscle fiber development GO:0048743 9.26 MYOD1 MYOG
12 muscle cell fate commitment GO:0042693 9.16 MYOD1 MYOG
13 glomerular endothelium development GO:0072011 8.62 CD34 PECAM1

Molecular functions related to Spindle Cell Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.35 CR2 DDIT3 KIT PECAM1 TERT
2 transcription factor binding GO:0008134 8.92 CD34 DDIT3 MYOD1 TLE1

Sources for Spindle Cell Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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