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MCID: SPN009
MIFTS: 41

Spindle Cell Rhabdomyosarcoma

Categories: Cancer diseases, Muscle diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Spindle Cell Rhabdomyosarcoma

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MalaCards integrated aliases for Spindle Cell Rhabdomyosarcoma:

Name: Spindle Cell Rhabdomyosarcoma 12 15 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Muscle diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3260
NCIt 49 C6519
SNOMED-CT 67 128749008 404055006
UMLS 71 C1266134
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Summaries for Spindle Cell Rhabdomyosarcoma

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MalaCards based summary : Spindle Cell Rhabdomyosarcoma is related to embryonal rhabdomyosarcoma and leiomyosarcoma. An important gene associated with Spindle Cell Rhabdomyosarcoma is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Neural Crest Differentiation and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Vincristine and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, lymph node and spinal cord, and related phenotypes are Decreased influenza A H1N1 (A/WSN/33) virus numbers and cellular

Wikipedia : 74 Spindle cell rhabdomyosarcoma is a subtype of embryonal rhabdomyosarcoma first described by Cavazzana,... more...

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Related Diseases for Spindle Cell Rhabdomyosarcoma

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Diseases related to Spindle Cell Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 embryonal rhabdomyosarcoma 31.8 PAX7 PAX3 MYOG MYOD1 MB DES
2 leiomyosarcoma 30.6 MYOG MB DES
3 prostate rhabdomyosarcoma 30.5 MYOG MYOD1
4 malignant triton tumor 30.0 MYOG MYOD1 MB DES
5 hemangiopericytoma, malignant 29.7 MYOG DES
6 adult fibrosarcoma 29.6 MYOG MYOD1 MAML3
7 congenital fibrosarcoma 29.6 VGLL2 MYOG DES CCNB3
8 sarcoma, synovial 29.5 PAX3 MYOG DES CCNB3
9 rhabdomyosarcoma 29.5 VGLL2 PAX7 PAX3 NCOA2 MYOG MYOD1
10 giant cell myocarditis 10.4 MB DES
11 malignant fibrous histiocytoma of bone 10.4 MYOD1 DES
12 undifferentiated embryonal sarcoma of the liver 10.4 MYOG MYOD1
13 pineal region teratoma 10.4 MYOG MYOD1
14 gliomatosis peritonei 10.4 GFAP DES
15 prostate embryonal rhabdomyosarcoma 10.4 MYOG MYOD1
16 primitive neuroectodermal tumor of the cervix uteri 10.4 GFAP DES
17 cervical polyp 10.4 MYOG DES
18 prostate sarcoma 10.4 MYOG MYOD1
19 lung combined type small cell carcinoma 10.3 MYOG GFAP
20 cutaneous leiomyosarcoma 10.3 GFAP DES
21 syringocystadenoma papilliferum 10.3 GFAP DES
22 parachordoma 10.3 GFAP DES
23 prostate stromal sarcoma 10.3 MYOG MYOD1
24 extraosseous ewing sarcoma 10.3 MYOG MYOD1
25 epithelioid leiomyosarcoma 10.3 MB DES
26 rare tumor 10.3
27 rhabdoid tumor predisposition syndrome 1 10.3 MYOD1 DES
28 endobronchial leiomyoma 10.3 MYOG GFAP
29 olfactory nerve neoplasm 10.3 MYOG GFAP
30 cranial nerve malignant neoplasm 10.3 MYOG GFAP
31 gallbladder sarcoma 10.3 MYOG MYOD1 DES
32 fibrosarcoma 10.2
33 embryonal sarcoma 10.2 MYOG MYOD1 DES
34 melanotic neuroectodermal tumor 10.2 MYOG GFAP
35 skeletal muscle neoplasm 10.2 MYOG MYOD1 MB
36 horner's syndrome 10.2 MYOG MYOD1 DES
37 bilateral retinoblastoma 10.2 MYOG MB DES
38 myofibroma 10.2 MYOG MB DES
39 adenosarcoma 10.2 MB DES
40 medulloepithelioma 10.2 GFAP DES
41 gas gangrene 10.2 MYOG MYOD1 MB
42 dedifferentiated liposarcoma 10.2 MYOG MB DES
43 pseudosarcomatous fibromatosis 10.2 MYOG DES
44 liposarcoma 10.2 MYOG MB DES
45 soft tissue sarcoma 10.2
46 kidney rhabdoid cancer 10.2 MB CCNB3
47 cellular congenital mesoblastic nephroma 10.1 VGLL2 CCNB3
48 ectomesenchymoma 10.1 PAX3 MYOG DES
49 congenital mesoblastic nephroma 10.1 VGLL2 CCNB3
50 orbit rhabdomyosarcoma 10.1 PAX3 MYOG MB

Graphical network of the top 20 diseases related to Spindle Cell Rhabdomyosarcoma:



Diseases related to Spindle Cell Rhabdomyosarcoma
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Symptoms & Phenotypes for Spindle Cell Rhabdomyosarcoma

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GenomeRNAi Phenotypes related to Spindle Cell Rhabdomyosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/WSN/33) virus numbers GR00195-A-2 8.8 CCNB3 CRYAA MYOD1

MGI Mouse Phenotypes related to Spindle Cell Rhabdomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 CCNB3 DES GFAP MAML3 MB MYOG
2 growth/size/body region MP:0005378 9.81 GFAP MAML3 MB MYOD1 MYOG NCOA2
3 embryo MP:0005380 9.8 MAML3 MB MYOG NCOA2 PAX3 PAX7
4 muscle MP:0005369 9.61 DES GFAP MB MYOD1 MYOG PAX3
5 normal MP:0002873 9.23 GFAP MAML3 MYOD1 MYOG PAX3 PAX7
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Drugs & Therapeutics for Spindle Cell Rhabdomyosarcoma

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Drugs for Spindle Cell Rhabdomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
2
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4 Immunologic Factors Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Immunosuppressive Agents Phase 3
7 Anti-Bacterial Agents Phase 3
8 Anti-Infective Agents Phase 3
9 Alkylating Agents Phase 3
10 Cactinomycin Phase 3
11 Tubulin Modulators Phase 3
12 Antirheumatic Agents Phase 3
13 Antimitotic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vincristine, Dactinomycin, and Lower Doses of Cyclophosphamide With or Without Radiation Therapy for Patients With Newly Diagnosed Low-Risk Embryonal/Botryoid/Spindle Cell Rhabdomyosarcoma Active, not recruiting NCT00075582 Phase 3 dactinomycin;cyclophosphamide;vincristine sulfate

Search NIH Clinical Center for Spindle Cell Rhabdomyosarcoma

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Genetic Tests for Spindle Cell Rhabdomyosarcoma

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Anatomical Context for Spindle Cell Rhabdomyosarcoma

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MalaCards organs/tissues related to Spindle Cell Rhabdomyosarcoma:

40
Bone, Lymph Node, Spinal Cord, Kidney, Uterus, Prostate, Testes
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Publications for Spindle Cell Rhabdomyosarcoma

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Articles related to Spindle Cell Rhabdomyosarcoma:

(show top 50) (show all 69)
# Title Authors PMID Year
1
Epithelioid and spindle cell rhabdomyosarcoma with FUS-TFCP2 or EWSR1-TFCP2 fusion: report of two cases. 61
32556562 2020
2
A rare case of congenital spindle cell rhabdomyosarcoma with TEAD1-NCOA2 fusion: A subset of spindle cell rhabdomyosarcoma with indolent behavior. 61
31999033 2020
3
Congenital spindle cell rhabdomyosarcoma. 61
31339226 2019
4
Beyond "Triton": Malignant Peripheral Nerve Sheath Tumors With Complete Heterologous Rhabdomyoblastic Differentiation Mimicking Spindle Cell Rhabdomyosarcoma. 61
31107719 2019
5
Spindle cell rhabdomyosarcoma in a lumbar vertebra with FUS-TFCP2 fusion. 61
30948206 2019
6
Combined Sclerosing and Spindle Cell Rhabdomyosarcoma in Previous Craniotomy Site: A Case Report and a Review of the Literature. 61
30270691 2019
7
Spindle cell rhabdomyosarcoma of the anterior mandible manifesting as a periapical lesion of pulpal origin: Case report. 61
29665230 2019
8
MYOD1-mutant spindle cell and sclerosing rhabdomyosarcoma: an aggressive subtype irrespective of age. A reappraisal for molecular classification and risk stratification. 61
30181563 2019
9
Primary Meningeal Rhabdomyosarcoma of the Spinal Cord of a Young Dog with Neuromelanocytosis and Multiple Cutaneous Neurofibromas. 61
30502797 2018
10
Novel MEIS1-NCOA2 Gene Fusions Define a Distinct Primitive Spindle Cell Sarcoma of the Kidney. 61
30179902 2018
11
Evaluation of pan-TRK immunohistochemistry in infantile fibrosarcoma, lipofibromatosis-like neural tumour and histological mimics. 61
29863809 2018
12
Expression of PAX3 Distinguishes Biphenotypic Sinonasal Sarcoma From Histologic Mimics. 61
29863547 2018
13
Spindle cell rhabdomyosarcoma of bone with FUS-TFCP2 fusion: confirmation of a very recently described rhabdomyosarcoma subtype. 61
29758589 2018
14
Lumbar Intraspinal Spindle Cell Rhabdomyosarcoma as a Rare Cause of Spinal Stenosis: A Case Report. 61
29452297 2018
15
Oral rhabdomyosarcoma in an adult male: A rare case report. 61
30158795 2018
16
Fibroblastic and myofibroblastic tumors of children: new genetic entities and new ancillary testing. 61
30613391 2018
17
TFG-MET fusion in an infantile spindle cell sarcoma with neural features. 61
28510278 2017
18
FOSB is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma. 61
28009608 2017
19
Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) in the adolescent population. 61
28262537 2017
20
Biphenotypic sinonasal sarcoma with diffuse infiltration and intracranial extension: a case report. 61
31966535 2017
21
Mixed Botryoid and Spindle Cell Bladder Rhabdomyosarcoma: An Outstanding Pediatric Case. 61
28116202 2017
22
MYOD1 (L122R) mutations are associated with spindle cell and sclerosing rhabdomyosarcomas with aggressive clinical outcomes. 61
27562493 2016
23
Spindle-cell rhabdomyosarcoma of the thumb: Rare site, rare tumor in a child. 61
27502215 2016
24
A rare case of multifocal pseudomyogenic hemangioendothelioma, involving soft tissues and bone, misdiagnosed as a rhabdomyosarcoma: Diagnostic and treatment implications. 61
27510684 2016
25
A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases. 61
26501226 2016
26
Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. 61
26585554 2016
27
Paratesticular Spindle Cell Rhabdomyosarcoma. 61
26500726 2015
28
Spindle cell/sclerosing rhabdomyosarcoma: case series from a single institution emphasizing morphology, immunohistochemistry and follow-up. 61
26823695 2015
29
Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: evidence for a common pathogenesis. 61
24824843 2014
30
An Adult Case of Paratesticular Spindle Cell Rhabdomyosarcoma. 61
26839788 2014
31
An adult spindle cell rhabdomyosarcoma in the head and neck region with long-term survival: a case report. 61
24946859 2014
32
Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. 61
24272621 2014
33
Spindle cell rhabdomyosarcoma of the retroperitoneum: an unusual case developed in a pregnant woman but obscured by pregnancy. 61
25197361 2014
34
Spindle cell rhabdomyosarcoma in the hypopharynx of an adult. 61
25197406 2014
35
Spindle cell rhabdomyosarcoma of the prostate. 61
23320845 2013
36
Spindle cell rhabdomyosarcoma: a brief diagnostic review and differential diagnosis. 61
23899074 2013
37
Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. 61
23463663 2013
38
Spindle cell rhabdomyosarcoma displaying CD34 positivity: a potential diagnostic pitfall; report of two pediatric cases. 61
24022313 2013
39
Spindle cell rhabdomyosarcoma of the neck with t(6;8) translocation: report of a case and literature review. 61
23113671 2013
40
Spindle Cell Sarcomas. 61
26837645 2011
41
Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature. 61
19017660 2010
42
Aggressive spindle cell rhabdomyosarcoma in an 11-month-old boxer dog. 61
20460837 2010
43
Exfoliative cytologic findings of maxillary sinus spindle cell rhabdomyosarcoma. 61
20518428 2010
44
[Spindle cell rhabdomyosarcoma in adults: a new entity in the spectrum of malignant mesenchymal tumors of soft tissues]. 61
19997735 2010
45
Unique case of giant adult paratesticular spindle cell rhabdomyosarcoma. 61
19036416 2009
46
Radiation-induced mandibular adult spindle cell rhabdomyosarcoma. 61
18023143 2008
47
[Clinicopathologic analysis of spindle cell rhabdomyosarcoma: report of 8 cases]. 61
18646700 2008
48
[Sclerosing rhabdomyosarcoma: a clinicopathologic study of four cases with review of literature]. 61
18070445 2007
49
Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. 61
17013628 2006
50
Rhabdomyosarcomas in adults and children: an update. 61
17090187 2006
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Variations for Spindle Cell Rhabdomyosarcoma

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Cosmic variations for Spindle Cell Rhabdomyosarcoma:

9 (show top 50) (show all 435)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM88149182 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.668C>G p.P223R 17:7674863-7674863 3
2 COSM88120884 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.739A>G p.N247D 17:7674224-7674224 3
3 COSM87911460 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.961A>T p.K321* 17:7673567-7673567 3
4 COSM87900604 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 3
5 COSM87898463 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.733G>T p.G245C 17:7674230-7674230 3
6 COSM87898578 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.733G>A p.G245S 17:7674230-7674230 3
7 COSM87898351 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.743G>A p.R248Q 17:7674220-7674220 3
8 COSM88094731 SOX9 soft tissue,NS,rhabdomyosarcoma,embryonal c.76A>G p.M26V 17:72121467-72121467 3
9 COSM97041246 PTPRT soft tissue,NS,rhabdomyosarcoma,embryonal c.2277G>T p.Q759H 20:42248779-42248779 3
10 COSM146438832 PTPN11 soft tissue,NS,rhabdomyosarcoma,embryonal c.214G>A p.A72T 12:112450394-112450394 3
11 COSM146438781 PTPN11 soft tissue,NS,rhabdomyosarcoma,embryonal c.226G>C p.E76Q 12:112450406-112450406 3
12 COSM146439443 PTPN11 soft tissue,NS,rhabdomyosarcoma,embryonal c.1520G>T p.G507V 12:112489084-112489084 3
13 COSM146438825 PTPN11 soft tissue,NS,rhabdomyosarcoma,embryonal c.205G>A p.E69K 12:112450385-112450385 3
14 COSM90839845 PTCH1 soft tissue,NS,rhabdomyosarcoma,embryonal c.208G>A p.A70T 9:95506593-95506593 3
15 COSM90587293 POLE soft tissue,NS,rhabdomyosarcoma,embryonal c.5975G>C p.C1992S 12:132634215-132634215 3
16 COSM96437477 PIK3CG soft tissue,NS,rhabdomyosarcoma,embryonal c.2638G>A p.E880K 7:106883041-106883041 3
17 COSM87132301 PIK3CA soft tissue,NS,rhabdomyosarcoma,embryonal c.1624G>A p.E542K 3:179218294-179218294 3
18 COSM87132245 PIK3CA soft tissue,NS,rhabdomyosarcoma,embryonal c.3140A>G p.H1047R 3:179234297-179234297 3
19 COSM87132308 PIK3CA soft tissue,NS,rhabdomyosarcoma,embryonal c.1633G>A p.E545K 3:179218303-179218303 3
20 COSM88818803 PDGFRA soft tissue,NS,rhabdomyosarcoma,embryonal c.3195G>C p.E1065D 4:54295197-54295197 3
21 COSM97687376 NTRK3 soft tissue,NS,rhabdomyosarcoma,embryonal c.492C>A p.C164* 15:88137534-88137534 3
22 COSM97107326 NRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.181C>A p.Q61K 1:114713909-114713909 3
23 COSM97107379 NRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.35G>A p.G12D 1:114716126-114716126 3
24 COSM97107772 NRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.37G>C p.G13R 1:114716124-114716124 3
25 COSM97107813 NRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.34G>A p.G12S 1:114716127-114716127 3
26 COSM97107359 NRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.182A>G p.Q61R 1:114713908-114713908 3
27 COSM97108079 NRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.183A>T p.Q61H 1:114713907-114713907 3
28 COSM97107717 NRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.38G>T p.G13V 1:114716123-114716123 3
29 COSM97107724 NRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.34G>T p.G12C 1:114716127-114716127 3
30 COSM87643288 NOTCH1 soft tissue,NS,rhabdomyosarcoma,embryonal c.3277T>C p.Y1093H 9:136508280-136508280 3
31 COSM93680412 NF1 soft tissue,NS,rhabdomyosarcoma,embryonal c.7870G>C p.A2624P 17:31357269-31357269 3
32 COSM84820183 MYOD1 soft tissue,NS,rhabdomyosarcoma,embryonal c.365T>G p.L122R 11:17720147-17720147 3
33 COSM101727756 MAP3K1 soft tissue,NS,rhabdomyosarcoma,embryonal c.1337G>A p.C446Y 5:56871945-56871945 3
34 COSM87804028 KRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.38G>A p.G13D 12:25245347-25245347 3
35 COSM87804075 KRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.34G>T p.G12C 12:25245351-25245351 3
36 COSM87804005 KRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.35G>A p.G12D 12:25245350-25245350 3
37 COSM87804083 KRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.35G>C p.G12A 12:25245350-25245350 3
38 COSM87808527 KRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.182A>T p.Q61L 12:25227342-25227342 3
39 COSM87690443 KMT2D soft tissue,NS,rhabdomyosarcoma,embryonal c.1291G>T p.E431* 12:49052392-49052392 3
40 COSM102156541 KDM6A soft tissue,NS,rhabdomyosarcoma,embryonal c.493C>T p.R165* 23:45020659-45020659 3
41 COSM112988832 HRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.37G>C p.G13R 11:534286-534286 3
42 COSM112988997 HRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.34G>T p.G12C 11:534289-534289 3
43 COSM112989371 HRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.34G>A p.G12S 11:534289-534289 3
44 COSM112988917 HRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.35G>T p.G12V 11:534288-534288 3
45 COSM112988925 HRAS soft tissue,NS,rhabdomyosarcoma,embryonal c.181C>A p.Q61K 11:533875-533875 3
46 COSM107501436 FGFR1 soft tissue,NS,rhabdomyosarcoma,embryonal c.1704G>T p.M568I 8:38417358-38417358 3
47 COSM92447825 ERCC5 soft tissue,NS,rhabdomyosarcoma,embryonal c.3256G>A p.G1086R 13:102875598-102875598 3
48 COSM122749648 ENSG00000282278 soft tissue,NS,rhabdomyosarcoma,embryonal c.2475G>C p.E825D 4:54295197-54295197 3
49 COSM128911139 DICER1 soft tissue,NS,rhabdomyosarcoma,embryonal c.2062C>T p.R688* 14:95112226-95112226 3
50 COSM128908198 DICER1 soft tissue,NS,rhabdomyosarcoma,embryonal c.5425G>A p.G1809R 14:95091305-95091305 3
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Expression for Spindle Cell Rhabdomyosarcoma

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Search GEO for disease gene expression data for Spindle Cell Rhabdomyosarcoma.
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Pathways for Spindle Cell Rhabdomyosarcoma

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Pathways related to Spindle Cell Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neural Crest Differentiation 1
11.14 PAX7 PAX3 GFAP
2
Mesenchymal Stem Cells and Lineage-specific Markers 64
11 PAX7 PAX3 MYOG MYOD1 DES
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GO Terms for Spindle Cell Rhabdomyosarcoma

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Cellular components related to Spindle Cell Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.73 VGLL2 TFCP2 TEAD1 PAX7 PAX3 NCOA2
2 nuclear chromatin GO:0000790 9.17 TFCP2 TEAD1 PAX7 PAX3 NCOA2 MYOG

Biological processes related to Spindle Cell Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.87 VGLL2 TEAD1 PAX7 PAX3 NCOA2 MYOG
2 cellular response to estradiol stimulus GO:0071392 9.56 MYOG MYOD1
3 positive regulation of muscle cell differentiation GO:0051149 9.55 MYOG MYOD1
4 skeletal muscle fiber development GO:0048741 9.54 MYOG MYOD1
5 skeletal muscle tissue regeneration GO:0043403 9.52 PAX7 MYOG
6 positive regulation of myoblast differentiation GO:0045663 9.51 MYOG MYOD1
7 positive regulation of myoblast fusion GO:1901741 9.49 MYOG MYOD1
8 intermediate filament organization GO:0045109 9.48 GFAP DES
9 myoblast differentiation GO:0045445 9.46 MYOG MYOD1
10 muscle organ development GO:0007517 9.46 PAX7 PAX3 MYOG MYOD1
11 mRNA transcription by RNA polymerase II GO:0042789 9.43 TFCP2 MYOG
12 myotube differentiation GO:0014902 9.4 MYOG MYOD1
13 positive regulation of skeletal muscle fiber development GO:0048743 9.37 MYOG MYOD1
14 positive regulation of transcription by RNA polymerase II GO:0045944 9.28 VGLL2 TFCP2 TEAD1 PAX7 PAX3 NCOA2
15 muscle cell fate commitment GO:0042693 9.26 MYOG MYOD1
16 skeletal muscle tissue development GO:0007519 9.26 VGLL2 PAX7 MYOG MYOD1

Molecular functions related to Spindle Cell Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.73 TFCP2 TEAD1 PAX7 PAX3 MYOG MYOD1
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.72 TFCP2 TEAD1 NCOA2 MYOG MYOD1
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.71 TFCP2 TEAD1 MYOG MYOD1
4 transcription coactivator activity GO:0003713 9.67 VGLL2 NCOA2 MYOD1 MAML3
5 protein dimerization activity GO:0046983 9.63 NCOA2 MYOG MYOD1
6 sequence-specific DNA binding GO:0043565 9.63 TFCP2 TEAD1 PAX7 PAX3 MYOG MYOD1
7 nuclear hormone receptor binding GO:0035257 9.43 NCOA2 MYOD1
8 proximal promoter sequence-specific DNA binding GO:0000987 9.26 TFCP2 TEAD1 MYOG MYOD1
9 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.23 VGLL2 TFCP2 TEAD1 PAX7 PAX3 NCOA2
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Sources for Spindle Cell Rhabdomyosarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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