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MCID: SPN009
MIFTS: 39

Spindle Cell Rhabdomyosarcoma

Categories: Cancer diseases, Muscle diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Spindle Cell Rhabdomyosarcoma

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MalaCards integrated aliases for Spindle Cell Rhabdomyosarcoma:

Name: Spindle Cell Rhabdomyosarcoma 12 15 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Muscle diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3260
NCIt 50 C6519
SNOMED-CT 67 404055006
UMLS 71 C1266134
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Summaries for Spindle Cell Rhabdomyosarcoma

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MalaCards based summary : Spindle Cell Rhabdomyosarcoma is related to prostate rhabdomyosarcoma and adult fibrosarcoma. An important gene associated with Spindle Cell Rhabdomyosarcoma is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Vincristine and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spinal cord and uterus, and related phenotypes are muscle and normal

Wikipedia : 74 Spindle cell rhabdomyosarcoma is a subtype of embryonal rhabdomyosarcoma first described by Cavazzana,... more...

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Related Diseases for Spindle Cell Rhabdomyosarcoma

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Diseases related to Spindle Cell Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 prostate rhabdomyosarcoma 30.4 MYOG MYOD1
2 adult fibrosarcoma 30.4 MYOG MYOD1
3 embryonal rhabdomyosarcoma 30.4 PAX3 MYOG MYOD1 MB DES
4 sarcomatoid carcinoma 30.2 MYOG MUC1 MB DES
5 monophasic synovial sarcoma 30.2 S100B MUC1
6 hemangiopericytoma, malignant 29.9 S100B MYOG MUC1 DES
7 congenital fibrosarcoma 29.8 VGLL2 S100A1 MYOG DES
8 malignant peripheral nerve sheath tumor 29.8 S100B S100A1 MYOG MUC1
9 malignant triton tumor 29.8 S100B MYOG MYOD1 MB DES
10 leiomyosarcoma 29.7 S100B S100A1 MYOG MUC1 MB DES
11 sarcoma, synovial 29.4 S100B PAX3 MYOG MUC1 DES
12 rhabdomyosarcoma 29.3 VGLL2 S100B S100A1 PAX3 NCOA2 MYOG
13 spindle cell sarcoma 29.3 VGLL2 S100B NCOA2 MYOG MUC1 DES
14 bladder sarcoma 10.4 MYOG MYOD1
15 giant cell myocarditis 10.4 MB DES
16 malignant fibrous histiocytoma of bone 10.4 MYOD1 DES
17 pineal region teratoma 10.3 MYOG MYOD1
18 conventional leiomyosarcoma 10.3 MYOG MYOD1
19 prostate embryonal rhabdomyosarcoma 10.3 MYOG MYOD1
20 gliomatosis peritonei 10.3 GFAP DES
21 undifferentiated embryonal sarcoma of the liver 10.3 MYOG MYOD1
22 cervical polyp 10.3 MYOG DES
23 primitive neuroectodermal tumor of the cervix uteri 10.3 GFAP DES
24 rare tumor 10.3
25 prostate stromal sarcoma 10.3 MYOG MYOD1
26 adenosarcoma 10.3 MB DES
27 extraosseous ewing sarcoma 10.3 MYOG MYOD1
28 spindle cell thymoma 10.3 MUC1 DES
29 lung combined type small cell carcinoma 10.3 MYOG GFAP
30 cervical adenosarcoma 10.3 MYOG MYOD1
31 plasmablastic lymphoma 10.3 MUC1 DES
32 endobronchial leiomyoma 10.3 MYOG GFAP
33 fibrosarcoma 10.3
34 glomangioma 10.3 S100A1 DES
35 myxosarcoma 10.3 S100A1 MB
36 olfactory nerve neoplasm 10.3 MYOG GFAP
37 cranial nerve malignant neoplasm 10.3 MYOG GFAP
38 biphasic synovial sarcoma 10.3 MUC1 DES
39 ovarian benign neoplasm 10.3 MUC1 DES
40 papillary ependymoma 10.2 S100B GFAP
41 liposarcoma 10.2 MYOG MB DES
42 papillary tumor of the pineal region 10.2 S100A1 MUC1
43 gliofibroma 10.2 MYOD1 GFAP
44 inflammatory leiomyosarcoma 10.2 MYOG MYOD1 DES
45 gallbladder sarcoma 10.2 MYOG MYOD1 DES
46 sclerosing perineurioma 10.2 S100B MUC1
47 localized hypertrophic neuropathy 10.2 S100B MUC1
48 malignant giant cell tumor of soft parts 10.2 S100B MB
49 reticular perineurioma 10.2 S100B MUC1
50 chondromyxoid fibroma 10.2 S100A1 DES

Graphical network of the top 20 diseases related to Spindle Cell Rhabdomyosarcoma:



Diseases related to Spindle Cell Rhabdomyosarcoma
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Symptoms & Phenotypes for Spindle Cell Rhabdomyosarcoma

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MGI Mouse Phenotypes related to Spindle Cell Rhabdomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.61 DES GFAP MB MYOD1 MYOG PAX3
2 normal MP:0002873 9.23 GFAP MYOD1 MYOG PAX3 S100A1 S100B
Sources

Drugs & Therapeutics for Spindle Cell Rhabdomyosarcoma

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Drugs for Spindle Cell Rhabdomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
2
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4 Immunosuppressive Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Immunologic Factors Phase 3
7 Anti-Bacterial Agents Phase 3
8 Anti-Infective Agents Phase 3
9 Antirheumatic Agents Phase 3
10 Antimitotic Agents Phase 3
11 Tubulin Modulators Phase 3
12 Cactinomycin Phase 3
13 Alkylating Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vincristine, Dactinomycin, and Lower Doses of Cyclophosphamide With or Without Radiation Therapy for Patients With Newly Diagnosed Low-Risk Embryonal/Botryoid/Spindle Cell Rhabdomyosarcoma Active, not recruiting NCT00075582 Phase 3 dactinomycin;cyclophosphamide;vincristine sulfate

Search NIH Clinical Center for Spindle Cell Rhabdomyosarcoma

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Genetic Tests for Spindle Cell Rhabdomyosarcoma

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Anatomical Context for Spindle Cell Rhabdomyosarcoma

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MalaCards organs/tissues related to Spindle Cell Rhabdomyosarcoma:

40
Lymph Node, Spinal Cord, Uterus, Prostate, Tongue
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Publications for Spindle Cell Rhabdomyosarcoma

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Articles related to Spindle Cell Rhabdomyosarcoma:

(show top 50) (show all 73)
# Title Authors PMID Year
1
Testicular Torsion in a Rare Case of Prostatic Spindle Cell Rhabdomyosarcoma. 61
33505810 2020
2
Establishment and Characterization of a Sclerosing Spindle Cell Rhabdomyosarcoma Cell Line with a Complex Genomic Profile. 61
33322555 2020
3
SRF Fusions Other Than With RELA Expand the Molecular Definition of SRF-fused Perivascular Tumors. 61
33021523 2020
4
Epithelioid and spindle cell rhabdomyosarcoma with FUS-TFCP2 or EWSR1-TFCP2 fusion: report of two cases. 61
32556562 2020
5
[Giant spindle cell rhabdomyosarcoma of children in the thoracic cavity: a case report]. 61
32988163 2020
6
A rare case of congenital spindle cell rhabdomyosarcoma with TEAD1-NCOA2 fusion: A subset of spindle cell rhabdomyosarcoma with indolent behavior. 61
31999033 2020
7
Nasal spindle cell tumor with rhabdomyoblastic features: A rare and diagnostically difficult case. 61
33101687 2020
8
Congenital spindle cell rhabdomyosarcoma. 61
31339226 2019
9
Beyond "Triton": Malignant Peripheral Nerve Sheath Tumors With Complete Heterologous Rhabdomyoblastic Differentiation Mimicking Spindle Cell Rhabdomyosarcoma. 61
31107719 2019
10
Spindle cell rhabdomyosarcoma in a lumbar vertebra with FUS-TFCP2 fusion. 61
30948206 2019
11
Combined Sclerosing and Spindle Cell Rhabdomyosarcoma in Previous Craniotomy Site: A Case Report and a Review of the Literature. 61
30270691 2019
12
Spindle cell rhabdomyosarcoma of the anterior mandible manifesting as a periapical lesion of pulpal origin: Case report. 61
29665230 2019
13
MYOD1-mutant spindle cell and sclerosing rhabdomyosarcoma: an aggressive subtype irrespective of age. A reappraisal for molecular classification and risk stratification. 61
30181563 2019
14
Primary Meningeal Rhabdomyosarcoma of the Spinal Cord of a Young Dog with Neuromelanocytosis and Multiple Cutaneous Neurofibromas. 61
30502797 2018
15
Novel MEIS1-NCOA2 Gene Fusions Define a Distinct Primitive Spindle Cell Sarcoma of the Kidney. 61
30179902 2018
16
Evaluation of pan-TRK immunohistochemistry in infantile fibrosarcoma, lipofibromatosis-like neural tumour and histological mimics. 61
29863809 2018
17
Expression of PAX3 Distinguishes Biphenotypic Sinonasal Sarcoma From Histologic Mimics. 61
29863547 2018
18
Lumbar Intraspinal Spindle Cell Rhabdomyosarcoma as a Rare Cause of Spinal Stenosis: A Case Report. 61
29452297 2018
19
Spindle cell rhabdomyosarcoma of bone with FUS-TFCP2 fusion: confirmation of a very recently described rhabdomyosarcoma subtype. 61
29758589 2018
20
Oral rhabdomyosarcoma in an adult male: A rare case report. 61
30158795 2018
21
Fibroblastic and myofibroblastic tumors of children: new genetic entities and new ancillary testing. 61
30613391 2018
22
TFG-MET fusion in an infantile spindle cell sarcoma with neural features. 61
28510278 2017
23
FOSB is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma. 61
28009608 2017
24
Robot-assisted retroperitoneal lymph node dissection (RA-RPLND) in the adolescent population. 61
28262537 2017
25
Mixed Botryoid and Spindle Cell Bladder Rhabdomyosarcoma: An Outstanding Pediatric Case. 61
28116202 2017
26
Biphenotypic sinonasal sarcoma with diffuse infiltration and intracranial extension: a case report. 61
31966535 2017
27
MYOD1 (L122R) mutations are associated with spindle cell and sclerosing rhabdomyosarcomas with aggressive clinical outcomes. 61
27562493 2016
28
Spindle-cell rhabdomyosarcoma of the thumb: Rare site, rare tumor in a child. 61
27502215 2016
29
A rare case of multifocal pseudomyogenic hemangioendothelioma, involving soft tissues and bone, misdiagnosed as a rhabdomyosarcoma: Diagnostic and treatment implications. 61
27510684 2016
30
A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases. 61
26501226 2016
31
Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. 61
26585554 2016
32
Paratesticular Spindle Cell Rhabdomyosarcoma. 61
26500726 2015
33
Spindle cell/sclerosing rhabdomyosarcoma: case series from a single institution emphasizing morphology, immunohistochemistry and follow-up. 61
26823695 2015
34
Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: evidence for a common pathogenesis. 61
24824843 2014
35
An Adult Case of Paratesticular Spindle Cell Rhabdomyosarcoma. 61
26839788 2014
36
An adult spindle cell rhabdomyosarcoma in the head and neck region with long-term survival: a case report. 61
24946859 2014
37
Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. 61
24272621 2014
38
Spindle cell rhabdomyosarcoma in the hypopharynx of an adult. 61
25197406 2014
39
Spindle cell rhabdomyosarcoma of the retroperitoneum: an unusual case developed in a pregnant woman but obscured by pregnancy. 61
25197361 2014
40
Spindle cell rhabdomyosarcoma of the prostate. 61
23320845 2013
41
Spindle cell rhabdomyosarcoma: a brief diagnostic review and differential diagnosis. 61
23899074 2013
42
Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. 61
23463663 2013
43
Spindle cell rhabdomyosarcoma displaying CD34 positivity: a potential diagnostic pitfall; report of two pediatric cases. 61
24022313 2013
44
Spindle cell rhabdomyosarcoma of the neck with t(6;8) translocation: report of a case and literature review. 61
23113671 2013
45
Spindle Cell Sarcomas. 61
26837645 2011
46
Sclerosing spindle cell rhabdomyosarcoma in an adult: report of a new case and review of the literature. 61
19017660 2010
47
Aggressive spindle cell rhabdomyosarcoma in an 11-month-old boxer dog. 61
20460837 2010
48
Exfoliative cytologic findings of maxillary sinus spindle cell rhabdomyosarcoma. 61
20518428 2010
49
[Spindle cell rhabdomyosarcoma in adults: a new entity in the spectrum of malignant mesenchymal tumors of soft tissues]. 61
19997735 2010
50
Unique case of giant adult paratesticular spindle cell rhabdomyosarcoma. 61
19036416 2009
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Variations for Spindle Cell Rhabdomyosarcoma

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Cosmic variations for Spindle Cell Rhabdomyosarcoma:

9 (show top 50) (show all 435)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM93183630 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.743G>A p.R248Q 17:7674220-7674220 3
2 COSM112255322 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 3
3 COSM122271658 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.337G>T p.G113C 17:7674230-7674230 3
4 COSM145017865 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.616G>A p.G206S 17:7674230-7674230 3
5 COSM144013587 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.700G>A p.G234S 17:7674230-7674230 3
6 COSM143576669 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.551C>G p.P184R 17:7674863-7674863 3
7 COSM144015364 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.604C>T p.R202* 17:7674894-7674894 3
8 COSM143371076 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.616G>A p.G206S 17:7674230-7674230 3
9 COSM142845635 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.961A>T p.K321* 17:7673567-7673567 3
10 COSM121878773 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.241C>T p.R81* 17:7674894-7674894 3
11 COSM105622516 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 3
12 COSM112446896 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.739A>G p.N247D 17:7674224-7674224 3
13 COSM122105750 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.272C>G p.P91R 17:7674863-7674863 3
14 COSM142838784 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 3
15 COSM143946062 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.160C>T p.R54* 17:7674894-7674894 3
16 COSM144651337 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.616G>A p.G206S 17:7674230-7674230 3
17 COSM145221104 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.551C>G p.P184R 17:7674863-7674863 3
18 COSM88149182 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.668C>G p.P223R 17:7674863-7674863 3
19 COSM142570943 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.844A>T p.K282* 17:7673567-7673567 3
20 COSM105620276 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.743G>A p.R248Q 17:7674220-7674220 3
21 COSM142837352 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.743G>A p.R248Q 17:7674220-7674220 3
22 COSM144182541 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.706A>G p.N236D 17:7674224-7674224 3
23 COSM122271749 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.337G>A p.G113S 17:7674230-7674230 3
24 COSM111760544 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 3
25 COSM112264430 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.961A>T p.K321* 17:7673567-7673567 3
26 COSM142771096 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.551C>G p.P184R 17:7674863-7674863 3
27 COSM121876092 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.337G>T p.G113C 17:7674230-7674230 3
28 COSM122734259 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.337G>T p.G113C 17:7674230-7674230 3
29 COSM121888820 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.565A>T p.K189* 17:7673567-7673567 3
30 COSM111943171 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.739A>G p.N247D 17:7674224-7674224 3
31 COSM122735989 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.241C>T p.R81* 17:7674894-7674894 3
32 COSM144088618 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.160C>T p.R54* 17:7674894-7674894 3
33 COSM144310285 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.616G>T p.G206C 17:7674230-7674230 3
34 COSM144087230 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.256G>A p.G86S 17:7674230-7674230 3
35 COSM144653365 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.520C>T p.R174* 17:7674894-7674894 3
36 COSM142560281 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.626G>A p.R209Q 17:7674220-7674220 3
37 COSM143552762 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.622A>G p.N208D 17:7674224-7674224 3
38 COSM111770654 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.961A>T p.K321* 17:7673567-7673567 3
39 COSM122466647 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.343A>G p.N115D 17:7674224-7674224 3
40 COSM142837497 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.733G>A p.G245S 17:7674230-7674230 3
41 COSM122282790 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.565A>T p.K189* 17:7673567-7673567 3
42 COSM88120884 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.739A>G p.N247D 17:7674224-7674224 3
43 COSM142749760 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.622A>G p.N208D 17:7674224-7674224 3
44 COSM106053189 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.743G>A p.R248Q 17:7674220-7674220 3
45 COSM122495250 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.272C>G p.P91R 17:7674863-7674863 3
46 COSM144651227 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.616G>T p.G206C 17:7674230-7674230 3
47 COSM144013367 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.710G>A p.R237Q 17:7674220-7674220 3
48 COSM111758576 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.743G>A p.R248Q 17:7674220-7674220 3
49 COSM144129449 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.191C>G p.P64R 17:7674863-7674863 3
50 COSM87911460 TP53 soft tissue,NS,rhabdomyosarcoma,embryonal c.961A>T p.K321* 17:7673567-7673567 3
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Expression for Spindle Cell Rhabdomyosarcoma

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Search GEO for disease gene expression data for Spindle Cell Rhabdomyosarcoma.
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Pathways for Spindle Cell Rhabdomyosarcoma

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Pathways related to Spindle Cell Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
10.9 PAX3 MYOG MYOD1 DES
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GO Terms for Spindle Cell Rhabdomyosarcoma

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Cellular components related to Spindle Cell Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.81 TFCP2 TEAD1 S100B S100A1 PAX3 NCOA2
2 nucleus GO:0005634 9.73 VGLL2 TFCP2 TEAD1 S100B S100A1 PAX3
3 chromatin GO:0000785 9.17 TFCP2 TEAD1 PAX3 NCOA2 MYOG MYOD1

Biological processes related to Spindle Cell Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.95 VGLL2 TEAD1 PAX3 NCOA2 MYOG MYOD1
2 positive regulation of transcription, DNA-templated GO:0045893 9.8 TEAD1 PAX3 NCOA2 MYOG MYOD1
3 positive regulation of muscle cell differentiation GO:0051149 9.54 MYOG MYOD1
4 skeletal muscle fiber development GO:0048741 9.52 MYOG MYOD1
5 skeletal muscle tissue regeneration GO:0043403 9.51 MYOG MYOD1
6 muscle organ development GO:0007517 9.5 PAX3 MYOG MYOD1
7 positive regulation of myoblast differentiation GO:0045663 9.49 MYOG MYOD1
8 intermediate filament organization GO:0045109 9.46 GFAP DES
9 myoblast differentiation GO:0045445 9.43 MYOG MYOD1
10 myotube differentiation GO:0014902 9.37 MYOG MYOD1
11 positive regulation of skeletal muscle fiber development GO:0048743 9.26 MYOG MYOD1
12 positive regulation of transcription by RNA polymerase II GO:0045944 9.17 VGLL2 TFCP2 TEAD1 PAX3 NCOA2 MYOG
13 muscle cell fate commitment GO:0042693 9.16 MYOG MYOD1
14 skeletal muscle tissue development GO:0007519 9.13 VGLL2 MYOG MYOD1

Molecular functions related to Spindle Cell Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.67 TFCP2 TEAD1 MYOG MYOD1
2 DNA-binding transcription factor activity GO:0003700 9.65 TFCP2 TEAD1 PAX3 MYOG MYOD1
3 protein dimerization activity GO:0046983 9.61 NCOA2 MYOG MYOD1
4 sequence-specific double-stranded DNA binding GO:1990837 9.55 TFCP2 TEAD1 PAX3 MYOG MYOD1
5 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.5 TFCP2 TEAD1 PAX3 NCOA2 MYOG MYOD1
6 nuclear hormone receptor binding GO:0035257 9.4 NCOA2 MYOD1
7 S100 protein binding GO:0044548 9.32 S100B S100A1
8 proximal promoter sequence-specific DNA binding GO:0000987 8.92 TFCP2 TEAD1 MYOG MYOD1
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Sources for Spindle Cell Rhabdomyosarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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