MCID: SPN035
MIFTS: 51

Spindle Cell Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Sarcoma

MalaCards integrated aliases for Spindle Cell Sarcoma:

Name: Spindle Cell Sarcoma 12 6 15
Sarcoma 43 71
Sarcoma, Spindle Cell 71
Sarcoma Spindle Cell 54
Sarcoma - Category 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4235
MeSH 43 D012509
NCIt 49 C27005
SNOMED-CT 67 9801004
UMLS 71 C0205945 C1261473 C1299262

Summaries for Spindle Cell Sarcoma

Disease Ontology : 12 A sarcoma that results in cells that are spindle-shaped. They are usually resistant to radiation therapy.

MalaCards based summary : Spindle Cell Sarcoma, also known as sarcoma, is related to mediastinum sarcoma and ewing sarcoma of bone. An important gene associated with Spindle Cell Sarcoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Cytoskeletal Signaling. The drugs Lopinavir and Lamivudine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and breast.

Wikipedia : 74 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

Related Diseases for Spindle Cell Sarcoma

Diseases related to Spindle Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2174)
# Related Disease Score Top Affiliating Genes
1 mediastinum sarcoma 34.2 MDM2 KRT7
2 ewing sarcoma of bone 34.2 VIM DES
3 endometrial stromal sarcoma 33.9 VIM S100B DES ACTC1
4 alveolar soft part sarcoma 33.9 VIM MYOG DES ACTC1
5 reticulum cell sarcoma 33.9 VIM MUC1 DES ACTC1
6 gallbladder sarcoma 33.8 MYOG DES
7 pancreas sarcoma 33.8 SERPINA3 MDM2
8 extraskeletal ewing sarcoma 33.8 VIM MUC1 DES
9 epithelioid sarcoma 33.7 VIM MUC1 KRT7 CD34
10 esophagus sarcoma 33.6 SSX2 CD34
11 vulvar sarcoma 33.6 CD34 ACTC1
12 undifferentiated embryonal sarcoma of the liver 33.5 SERPINA3 MYOG MDM2
13 central epithelioid sarcoma 33.4 VIM KRT7 CD34
14 vulvar proximal-type epithelioid sarcoma 33.3 VIM KRT7 CD34
15 botryoid rhabdomyosarcoma 33.2 MYOG DES ACTC1
16 retroperitoneal sarcoma 33.0 SSX2 MYOG MDM2 CD34
17 dendritic cell tumor 32.9 VIM S100B NCOA2 MUC1 ACTC1
18 bone angioendothelial sarcoma 32.9 SSX1 SS18
19 meninges sarcoma 32.9 SSX2 SS18 SERPINA3
20 kidney sarcoma 32.8 SSX2 SSX1 SS18
21 uterine carcinosarcoma 32.8 VIM VEGFA MUC1 DES
22 embryonal sarcoma 32.5 VIM SERPINA3 S100B MYOG MDM2 DES
23 desmoplastic small round cell tumor 32.5 VIM MUC1 DES
24 reticulosarcoma 32.4 SERPINA3 MUC1 CDKN1B
25 adenosarcoma 32.1 VIM SERPINA3 DES ACTC1
26 lung sarcoma 32.1 SSX2 SSX1 SS18 CD34
27 rhabdoid cancer 32.1 SSX2 SS18 MYOG
28 bednar tumor 32.1 VIM S100B
29 biphasic synovial sarcoma 32.0 VIM SSX2 SSX1 SS18 MUC1 DES
30 mesothelioma, malignant 31.9 VIM NF2 MUC1 KRT7 DES
31 prostate angiosarcoma 31.8 VEGFA CD34
32 epithelioid cell synovial sarcoma 31.8 SSX2 SSX1 SS18 KRT7 CD34
33 uterus leiomyosarcoma 31.6 MYOG KRT7 CD34
34 breast leiomyosarcoma 31.5 VEGFA KRT7 CD34
35 chordoma 31.3 VIM VEGFA SERPINA3 S100B MUC1 KRT7
36 wilms tumor 1 31.1 VEGFA MYOG KRT7 CD34
37 soft tissue sarcoma 31.0 VEGFA MDM2
38 chondrosarcoma, extraskeletal myxoid 30.9 SSX2 SSX1 SS18 CD34
39 monophasic synovial sarcoma 30.9 VIM SSX2 SSX1 SS18 S100B MUC1
40 rhabdoid tumor predisposition syndrome 1 30.8 VIM MUC1 DES ACTC1
41 rare tumor 30.8 NF2 DES ACTC1
42 meningioma, radiation-induced 30.8 VIM S100B NF2 MUC1
43 malignant mesenchymoma 30.7 SSX2 SERPINA3 MYOG MDM2 DES CD34
44 leiomyoma 30.6 VIM DES CD34 ACTC1
45 benign mesothelioma 30.6 KRT7 CD34
46 dedifferentiated liposarcoma 30.6 MYOG MDM2 DES ACTC1
47 retroperitoneal fibrosis 30.5 VIM MDM2
48 pyogenic granuloma 30.5 CD34 ACTC1
49 secretory meningioma 30.5 VIM SERPINA3 NF2 MUC1 KRT7
50 lymphangiosarcoma 30.4 VEGFA CD34

Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to Spindle Cell Sarcoma

Symptoms & Phenotypes for Spindle Cell Sarcoma

Drugs & Therapeutics for Spindle Cell Sarcoma

Drugs for Spindle Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 603)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lopinavir Approved Phase 4 192725-17-0 92727
2
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
3
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
4
Fosaprepitant Approved Phase 4 172673-20-0 219090
5
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
6
Dalteparin Approved Phase 4 9005-49-6
7
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
8
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
9
Enoxaparin Approved Phase 4 9005-49-6 772
10 Cytochrome P-450 CYP3A Inhibitors Phase 4
11 neurokinin A Phase 4
12
Substance P Phase 4 33507-63-0 44359816
13 Neurokinin-1 Receptor Antagonists Phase 4
14 Anticoagulants Phase 4
15 Fibrinolytic Agents Phase 4
16 Heparin, Low-Molecular-Weight Phase 4
17 calcium heparin Phase 4
18 Platelet Aggregation Inhibitors Phase 4
19 Antipyretics Phase 4
20
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 5281106 54677470
21
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
22
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
23
Irinotecan Approved, Investigational Phase 3 97682-44-5, 100286-90-6 60838
24
Morphine Approved, Investigational Phase 3 57-27-2 5288826
25
Bortezomib Approved, Investigational Phase 3 179324-69-7 387447 93860
26
Nicotine Approved Phase 3 54-11-5 942 89594
27
Darbepoetin alfa Approved, Investigational Phase 3 209810-58-2, 11096-26-7
28
Abacavir Approved, Investigational Phase 2, Phase 3 136470-78-5 65140 441300
29
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
31
Sulfamethoxazole Approved Phase 3 723-46-6 5329
32
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
33
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
34
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
35
Varenicline Approved, Investigational Phase 3 249296-44-4 5310966
36
Durvalumab Approved, Investigational Phase 3 1428935-60-7
37
Dacarbazine Approved, Investigational Phase 2, Phase 3 4342-03-4 5351166
38
Epirubicin Approved Phase 3 56420-45-2 41867
39
Palbociclib Approved, Investigational Phase 3 571190-30-2 11431660 5005498 5330286
40
Olaparib Approved Phase 3 763113-22-0 23725625
41 Cranberry Approved, Investigational Phase 3
42 Grape Approved Phase 3
43
Ceritinib Approved Phase 3 1032900-25-6
44
Denosumab Approved Phase 3 615258-40-7
45
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
46
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
47
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
48
Idarubicin Approved Phase 3 58957-92-9 42890
49
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
50
Daunorubicin Approved Phase 3 20830-81-3 30323

Interventional clinical trials:

(show top 50) (show all 1716)
# Name Status NCT ID Phase Drugs
1 EpSSG (European Soft Tissue Sarcoma Study Group) Protocol for Non-Metastatic Rhabdomyosarcoma in Children Unknown status NCT00339118 Phase 4 doxorubicin, cytoxan
2 Optimizing Influenza Vaccination in Surgical Oncology Patients Unknown status NCT01698177 Phase 4
3 A Randomized Comparison of Protease Inhibitor-based Versus Non-nucleoside Reverse Transcriptase Inhibitor-based Antiretroviral Therapy for Initial Treatment of Individuals With AIDS-related Kaposi's Sarcoma in Sub-Saharan Africa Completed NCT00444379 Phase 4 Lopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir
4 A Prospective Randomized Trial Comparing the Response of HIV Kaposi's Sarcoma (KS) to HAART Versus the Combination of HAART and Chemotherapy (CXT) Completed NCT00380770 Phase 4 Generic HAART Triomune : d4T, 3TC, NVP;Generic HAART Triomune : d4T, 3TC, NVP and chemotherapy ABV
5 Prospective, Randomized Evaluation of Hyperbaric Oxygen Therapy on Wound Healing Following Management of Soft Tissue Sarcoma With Neo-Adjuvant Radiation and Surgical Resection Recruiting NCT03144206 Phase 4 Hyperbaric oxygen
6 Pharmacologic Interaction Between Ifosfamide and Aprepitant in Treated Patients With Soft Tissue Sarcoma Recruiting NCT03514381 Phase 4 Patients starting a treatment with Doxorubicin and Ifosfamide
7 Quality of Life in Patients With Non-adipocyte Soft Tissue Sarcoma Under Palliative Chemotherapy or Pazopanib — a Randomized, Controlled Trial Recruiting NCT03735758 Phase 4 pazopanib or guideline conform chemotherapy
8 An Open Label, Multicenter, Non-Comparative, Phase IV Study of Panitumumab to Characterize Its Safety, Tolerability and Activity in Indian Subjects With Previously Treated Wild-Type RAS (KRAS and NRAS), Metastatic Colorectal Cancer Recruiting NCT02301962 Phase 4 Panitumumab
9 Tacrolimus for the Treatment of Superficial Kaposiform Hemangioendothelioma and Tufted Angioma: a Single Arm Prospective Study Recruiting NCT04056962 Phase 4 Tacrolimus ointment
10 Safety and Efficacy of Low-dose Sirolimus to Kaposiform Hemangioendothelioma:A Prospective, Randomized Open Trial Recruiting NCT04077515 Phase 4 Sirolimus(0.8mg/m2);Sirolimus(0.7mg/m2)
11 Low Molecular Weight Heparin Versus Aspirin for Venous Thromboembolism Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
12 Registry of Retroperitoneal, Abdominal, Pelvic and Truncal Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet® to Evaluate the Safety and Feasibility Over 5 Years Not yet recruiting NCT04033081 Phase 4
13 A Registered Randomized, Double-Blind, Placebo-Controlled (2:1), Multi-Centered Clinical Trial of Anlotinib as a Treatment for Soft Tissue Sarcoma Unknown status NCT02449343 Phase 2, Phase 3 Anlotinib;Placebo
14 Phase III Study About the Effects of the Addition of Polychemotherapy to Adjuvant Radiotherapy in the Treatment of Non-Metastatic Uterine Sarcomas Unknown status NCT00162721 Phase 3 doxorubicin, ifosfamide, cisplatin
15 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Adriamycin, Bleomycin, and Vincristine (ABV) in the Treatment of Severe AIDS-Related Kaposi's Sarcoma Unknown status NCT00002318 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
16 A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS) Unknown status NCT01344018 Phase 3
17 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
18 EUROPEAN INTERGROUP COOPERATIVE EWING'S SARCOMA STUDY [EICESS 92] Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
19 Intensified Methotrexate, Vinblastine, Doxorubicin and Cisplatin +/-Panitumumab as First-line Treatment of Advanced Urothelial Carcinoma in Patients Without Harvey Nor Kirsten Rat Sarcoma Viral Oncogene Homolog Mutations. Phase II Study Unknown status NCT02818725 Phase 3 Chemotherapy;panitumumab
20 Phase III Study of The Role of Barrier Resection in Local Control in Treatment of Extremity Soft Tissue Sarcomas Unknown status NCT02120768 Phase 3
21 European Ewing Tumour Working Initiative of National Groups Ewing Tumour Studies 1999 (EURO-E.W.I.N.G.99) Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
22 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
23 A Phase III Randomized Trial of Gemcitabine (NSC# 613327) Plus Docetaxel (NSC# 628503) Followed by Doxorubicin (NSC# 123127) Versus Observation for Uterus-Limited, High-Grade Uterine Leiomyosarcoma Unknown status NCT01533207 Phase 3 Docetaxel;Doxorubicin Hydrochloride;Gemcitabine Hydrochloride
24 A Double-Blind Randomized Placebo Controlled Trial for Prevention of Tuberculosis-Immune Reconstitution Inflammatory Syndrome With Non-Steroid Anti-Inflammatory Drugs (NSAIDs) in HIV-Infected Adults Unknown status NCT02060006 Phase 3 Meloxicam 7.5mg daily for 8 weeks
25 A Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Ifosfamide Plus Paclitaxel in Chemotherapy-Naive Patients With Newly Diagnosed Stage I-IV, Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumors) of the Uterus, Fallopian Tube, Peritoneum or Ovary Unknown status NCT00954174 Phase 3 Carboplatin;Ifosfamide;Paclitaxel
26 A Protocol For Nonmetastatic Rhabdomyosarcoma [RMS-2005] Unknown status NCT00379457 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate;vinorelbine tartrate
27 Prospective and Randomized Study of Fixed Versus Flexible Prophylactic Administration of Granulocyte Colony-Stimulating Factor (G-CSF) in Children With Cancer Unknown status NCT01987596 Phase 3
28 Comparing the Effectiveness of Combined Hyperthermia and External Beam Radiation (EBRT) Versus EBRT Alone in Treating Patients With Painful Bone Metastases Unknown status NCT01842048 Phase 3
29 A Randomized Double Blind Phase III Trial of Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior Therapy Completed NCT00753688 Phase 3 PAZOPANIB;Placebo
30 A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma. Completed NCT00002093 Phase 3 Daunorubicin (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
31 Use of Stealth Liposomal Doxorubicin HCl ( DOX-SL ) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma. Completed NCT00002147 Phase 3 Doxorubicin hydrochloride (liposomal)
32 A Multicenter, Randomized, Open-Label Phase 3 Study to Investigate the Efficacy and Safety of Aldoxorubicin Compared to Investigator's Choice in Subjects With Metastatic, Locally Advanced, or Unresectable Soft Tissue Sarcomas Who Either Relapsed or Were Refractory to Prior Non-Adjuvant Chemotherapy Completed NCT02049905 Phase 3 Aldoxorubicin;Investigator's Choice Treatment (Darcabazine, Pazopanib, Gemcitabine + Docetaxel, Doxorubicin, Ifosfamide)
33 Safety and Efficacy of (PN-152,243)/PN-196,444 in the Prevention of Thrombocytopenia Administered to Patients With High-Risk Sarcoma Receiving Intensive Chemotherapy (Adriamycin and Ifosfamide (AI)) Completed NCT00038311 Phase 3 PN-152,243)/PN-196,444
34 Double-Blind Randomized Evaluation of Clinical Benefits of DOXIL in Patients With AIDS-Related Kaposi's Sarcoma Treated With DOXIL or DaunoXome Completed NCT00002985 Phase 3 daunorubicin hydrochloride;pegylated liposomal doxorubicin hydrochloride
35 Open Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma Completed NCT00002319 Phase 3 Doxorubicin hydrochloride (liposomal)
36 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
37 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
38 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002105 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate
39 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
40 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
41 A Phase III Multicenter, International, Randomized, Double-blind, Placebo-controlled Study of Doxorubicin Plus Palifosfamide-tris vs. Doxorubicin Plus Placebo in Patients With Front-line Metastatic Soft Tissue Sarcoma. Completed NCT01168791 Phase 3 doxorubicin in combination with palifosfamide-tris;doxorubicin in combination with placebo
42 A Randomized Phase III Trial Comparing Trabectedin (Yondelis®) to the Best Supportive Care in Patients With Advanced Soft Tissue Sarcoma Completed NCT02672527 Phase 3 Trabectedin;Dexamethasone
43 Phase III Prospective Randomized Trial of Pre-Operative Intensity Modulated Radiation Therapy (IMRT) Plus Surgery Versus Surgery Alone For Primary Retroperitoneal Sarcoma Completed NCT00131898 Phase 3
44 Randomised Trial Of Single Agent Doxorubicin Versus Doxorubicin Plus Ifosfamide In The First Line Treatment Of Advanced Or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
45 Ph III Random Trial of 120-Min Infusion Gemcitabine v. 90-Min Infusion Gemcitabine + Docetaxel in Unresectable Soft Tissue Sarcoma: A Multi-Disciplinary Trial of the North Amer. Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00142571 Phase 3 Gemcitabine;Docetaxel
46 Phase III Randomized Study of Adjuvant Pelvic Radiotherapy Versus Observation Alone in Patients With Completely Resected, Stage I or II, High-Grade Uterine Sarcoma Completed NCT00002459 Phase 3
47 A Phase III Randomized Placebo Controlled and Double Blinded Study of IM862 for Patients With Muco-Cutaneous AIDS Associated Kaposi's Sarcoma Completed NCT00002445 Phase 3 IM862
48 A Phase III Randomized Study of Preoperative Radiation Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcomas (RPS) Completed NCT00091351 Phase 3
49 Randomized Study Comparing Neoadjuvant Chemotherapy Etoposide + Ifosfamide + Adriamycin (EIA) Combined With Regional Hyperthermia (RHT) Versus Neoadjuvant Chemotherapy Alone in the Treatment of High-Risk Soft Tissue Sarcomas in Adults Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
50 A Randomized Phase 3, Multicenter, Open-Label Study Comparing TH-302 in Combination With Doxorubicin vs. Doxorubicin Alone in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma Completed NCT01440088 Phase 3 TH-302 in Combination with Doxorubicin;Doxorubicin

Search NIH Clinical Center for Spindle Cell Sarcoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ifosfamide
Mitoxantrone
Mitoxantrone Hydrochloride
Thiotepa

Cochrane evidence based reviews: sarcoma

Genetic Tests for Spindle Cell Sarcoma

Anatomical Context for Spindle Cell Sarcoma

MalaCards organs/tissues related to Spindle Cell Sarcoma:

40
Bone, Lung, Breast, Myeloid, Kidney, Liver, Uterus

Publications for Spindle Cell Sarcoma

Articles related to Spindle Cell Sarcoma:

(show top 50) (show all 30395)
# Title Authors PMID Year
1
Carcinosarcoma in the pouch of douglas. 54 61
19484471 2010
2
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. 54 61
17343592 2007
3
Primary intraabdominal synovial sarcoma: a case report. 54 61
15800696 2005
4
An ultrastructural, immunohistochemical, and cytogenetical study of a monophasic pulmonary synovial sarcoma: implications of the frequent ultrastructure of oligocilia and concentric membranous bodies with positive immunostaining for VS38c and MEF2. 54 61
12907368 2003
5
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors. 54 61
11570907 2001
6
Malignant mixed müllerian tumors of the ovary. 54 61
10820916 2000
7
Corticomedullary tumors of the adrenal glands. Report of two cases. Association of corticomedullary tumor with spindle cell sarcoma. 54 61
9122025 1996
8
Primary retroperitoneal synovial sarcoma. 54 61
7849384 1994
9
Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. 54 61
1718079 1991
10
A rare case of Ewing's sarcoma of the kidney. 61
31890597 2020
11
Update on oncogenesis and therapy for Kaposi sarcoma. 61
31815777 2020
12
Myeloid sarcoma. 61
31904666 2020
13
Novel SS18-NEDD4 gene fusion in a primary renal synovial sarcoma. 61
31595587 2020
14
Primary Intra-abdominal Ewing's Sarcoma in Adults: A Multimodality Imaging Spectrum. 61
30642618 2020
15
Myeloid sarcoma of the tongue as a first manifestation of acute promyelocytic leukemia: A case report. 61
32021572 2020
16
An Exceptional Vulvar Tumor: Myeloid Sarcoma of the Labia Majora. 61
30829759 2020
17
Myeloid Sarcoma With CBFB-MYH11 Fusion (inv(16) or t(16;16)) Prevails in the Abdomen. 61
31671434 2020
18
Hybrid Low-Grade Fibromyxoid Sarcoma and Sclerosing Epithelioid Fibrosarcoma of the Pancreas. 61
32034641 2020
19
Long-term impact of lymphadenectomies in patients with low-grade, early-stage uterine endometrial stroma sarcoma. 61
32022392 2020
20
Primary tricuspid valve intimal sarcoma found in chest wall and lung tumors. 61
31500441 2020
21
Prognoses of superficial soft tissue sarcoma: The importance of fascia-tumor relationship on MRI. 61
31610904 2020
22
Outcome of Ewing's sarcoma of the scapula-a long-term follow-up study. 61
31735563 2020
23
Undifferentiated small round cell sarcoma in a young male: a case report. 61
32014859 2020
24
Investigation on the genomic characterization of uterine sarcoma for rAd-p53 combined with chemotherapy treatment. 61
32013587 2020
25
Stereotactic Body Radiotherapy Versus Metastasectomy in Patients With Pulmonary Metastases From Soft Tissue Sarcoma. 61
32024603 2020
26
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a case report and review of the literature. 61
32039736 2020
27
Soft tissue sarcoma: DWI and DCE-MRI parameters correlate with Ki-67 labeling index. 61
31630234 2020
28
Extended ray resection for sarcoma of the hand: long-term survival and functional results. 61
31711343 2020
29
Emergent radiation therapy to cardiac Ewing's sarcoma with haemodynamic failure due to pulmonary artery compression. 61
31365050 2020
30
Low-grade fibromyxoid sarcoma: A report of the Cooperative Weichteilsarkom Studiengruppe (CWS). 61
31736251 2020
31
Pilot Trial AMC-063: Safety and Efficacy of Bortezomib in AIDS-associated Kaposi Sarcoma. 61
31624104 2020
32
Iatrogenic Kaposi sarcoma in a patient treated with ruxolitinib: A case report. 61
31829460 2020
33
Kaposi sarcoma involving gastrointestinal tract in VIH. 61
31735522 2020
34
Parkin expression reverses mitochondrial dysfunction in fused in sarcoma-induced amyotrophic lateral sclerosis. 61
31290213 2020
35
Malignant peripheral nerve-sheath tumors in an adolescent patient with mosaic localized NF1: A case report. 61
31929887 2020
36
Incidental Detection of Pleomorphic Sarcoma on 68Ga-PSMA PET/CT in a Patient With Prostate Cancer. 61
31490315 2020
37
Pediatric myeloid sarcoma: a single institution clinicopathologic and molecular analysis. 61
31682773 2020
38
Surgical outcomes and prognostic factors of non-metastatic radiation-induced sarcoma of bone. 61
31703834 2020
39
Sarcoma Surveillance: A Review of Current Evidence and Guidelines. 61
31651565 2020
40
Right heart masses in a patient with endometrial stromal sarcoma. 61
31074021 2020
41
A Rare Pulmonary Artery Sarcoma Masquerading as Pulmonary Embolus. 61
31279785 2020
42
Extremity Soft Tissue Sarcoma: Role of Local Control. 61
32025823 2020
43
Glycogen synthase kinase 3β as a potential therapeutic target in synovial sarcoma and fibrosarcoma. 61
31808966 2020
44
TLE1 expression fails to distinguish between synovial sarcoma, atypical fibroxanthoma, and dermatofibrosarcoma protuberans. 61
31614009 2020
45
The Role of Neoadjuvant Chemotherapy in Resectable Primary Synovial Sarcoma. 61
32014949 2020
46
Complications after thigh sarcoma resection. 61
32020627 2020
47
SMARCA4-deficient Uterine Sarcoma and Undifferentiated Endometrial Carcinoma Are Distinct Clinicopathologic Entities. 61
31567195 2020
48
FDG PET/CT of Primary Ewing Sarcoma of IVC. 61
31876813 2020
49
Precision medicine in Ewing sarcoma: a translational point of view. 61
32026343 2020
50
Outcomes following proton therapy for Ewing sarcoma of the cranium and skull base. 61
31736243 2020

Variations for Spindle Cell Sarcoma

ClinVar genetic disease variations for Spindle Cell Sarcoma:

6 ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NF2 NM_016418.5(NF2):c.583_589del (p.His195fs)deletion Pathogenic 585330 rs1569294187 22:30051646-30051652 22:29655657-29655663
2 MGA , NUTM1 der(15)t(5:15)(q23.2;q15.1)Translocation Pathogenic 585331
3 subset of 62 genes: ACTC1 , MEIS2 , SPRED1 GRCh37/hg19 15q14-15.1 chr15:34638237..42057083 complex variantcomplex Pathogenic 585332 15:34638237-42057083

Expression for Spindle Cell Sarcoma

Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for Spindle Cell Sarcoma

Pathways related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 SSX2 SSX1 SS18 MDM2 CDKN1B
2 11.59 VIM NF2 MUC1 KRT7 DES ACTC1
3 11.33 VIM VEGFA S100B
4 11.19 VIM DES ACTC1

GO Terms for Spindle Cell Sarcoma

Cellular components related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.83 VIM SSX2 SSX1 SS18 SERPINA3 S100B
2 cytoplasm GO:0005737 9.5 VIM VEGFA S100B NTRK3 NF2 NCOA2

Biological processes related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 VEGFA S100B NTRK3 MDM2 CDKN1B
2 lens fiber cell differentiation GO:0070306 9.37 NTRK3 NF2
3 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.33 MUC1 MDM2 CDKN1B
4 positive regulation of positive chemotaxis GO:0050927 9.32 VEGFA NTRK3
5 cellular response to antibiotic GO:0071236 9.26 MDM2 CDKN1B
6 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
7 positive regulation of gene expression GO:0010628 9.1 VIM VEGFA NTRK3 MDM2 CD34 ACTC1

Molecular functions related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 VIM VEGFA SSX2 SSX1 SS18 SERPINA3
2 p53 binding GO:0002039 9.13 NTRK3 MUC1 MDM2

Sources for Spindle Cell Sarcoma

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