MCID: SPN035
MIFTS: 57

Spindle Cell Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Sarcoma

MalaCards integrated aliases for Spindle Cell Sarcoma:

Name: Spindle Cell Sarcoma 12 6 15
Sarcoma 44 72
Sarcoma, Spindle Cell 72
Sarcoma Spindle Cell 55
Sarcoma - Category 72

Classifications:



External Ids:

Disease Ontology 12 DOID:4235
MeSH 44 D012509
NCIt 50 C27005
SNOMED-CT 68 9801004
UMLS 72 C0205945 C1261473 C1299262

Summaries for Spindle Cell Sarcoma

Disease Ontology : 12 A sarcoma that results in cells that are spindle-shaped. They are usually resistant to radiation therapy.

MalaCards based summary : Spindle Cell Sarcoma, also known as sarcoma, is related to small cell sarcoma and epithelioid sarcoma. An important gene associated with Spindle Cell Sarcoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are ERK Signaling and Glioma. The drugs Lopinavir and Lamivudine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and myeloid, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 75 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

Related Diseases for Spindle Cell Sarcoma

Diseases related to Spindle Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2113)
# Related Disease Score Top Affiliating Genes
1 small cell sarcoma 33.9 NF2 MDM2
2 epithelioid sarcoma 33.4 VIM MUC1 KRT7
3 endometrial stromal sarcoma 33.4 VIM IL6 DES ACTC1
4 botryoid rhabdomyosarcoma 33.3 DES ACTC1
5 biphasic synovial sarcoma 32.8 VIM MUC1 DES
6 embryonal sarcoma 32.8 VIM S100B MDM2 DES
7 extraskeletal ewing sarcoma 32.7 VIM MUC1 DES
8 reticulum cell sarcoma 32.5 VIM MUC1 DES ACTC1
9 monophasic synovial sarcoma 32.2 VIM S100B MUC1 KRT7
10 bednar tumor 32.1 VIM S100B
11 dendritic cell tumor 32.0 VIM S100B MUC1 ACTC1
12 malignant mesenchymoma 31.9 NTRK3 MDM2 DES
13 desmoplastic small round cell tumor 31.5 VIM MUC1 DES
14 mesothelioma, malignant 31.2 VIM NF2 MUC1 KRT7
15 sarcoma, synovial 30.8 VIM MUC1 MDM2 KRT7 DES
16 leiomyoma 30.8 VIM DES ACTC1
17 mesenchymoma 30.8 MDM2 DES
18 retroperitoneal fibrosis 30.7 VIM MDM2
19 dedifferentiated liposarcoma 30.6 MDM2 DES ACTC1
20 fibrosarcoma 30.5 VIM NTRK3 DES
21 intravascular papillary endothelial hyperplasia 30.5 VIM ACTC1
22 epulis 30.4 VIM DES
23 liposarcoma 30.3 VIM MDM2 DES
24 pseudosarcomatous fibromatosis 30.2 VIM DES ACTC1
25 myopericytoma 30.2 S100B ACTC1
26 chordoma 30.2 VIM S100B MUC1 KRT7 DES
27 cystic nephroma 30.2 VIM DES
28 rhabdoid meningioma 30.2 VIM NF2
29 cellular schwannoma 30.1 S100B NF2 MDM2
30 secretory meningioma 30.1 VIM MUC1 KRT7
31 gliosarcoma 30.1 VIM S100B ACTC1
32 rhabdomyosarcoma 30.1 VIM MDM2 DES ACTC1
33 well-differentiated liposarcoma 30.1 MUC1 MDM2 KRT7
34 myoepithelioma 30.1 VIM S100B ACTC1
35 malignant fibrous histiocytoma of bone 30.0 MDM2 DES
36 lymphangiectasis 30.0 VIM ACTC1
37 amelanotic melanoma 30.0 VIM S100B
38 hemangiopericytoma, malignant 30.0 VIM S100B MUC1 MDM2 DES ACTC1
39 malignant giant cell tumor 30.0 S100B ACTC1
40 epithelioid leiomyosarcoma 30.0 VIM DES ACTC1
41 metanephric adenoma 29.9 VIM KRT7
42 smooth muscle tumor 29.9 VIM DES ACTC1
43 ovarian fibrothecoma 29.9 DES ACTC1
44 fibromatosis 29.8 VIM DES ACTC1
45 granular cell tumor 29.8 VIM S100B DES
46 infantile myofibromatosis 29.8 VIM DES ACTC1
47 neurilemmoma 29.8 VIM S100B NF2 DES
48 meningioma, radiation-induced 29.8 VIM S100B NF2 MUC1
49 lymphangiomatosis 29.7 VIM DES
50 glomus tumor 29.7 VIM DES ACTC1

Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to Spindle Cell Sarcoma

Symptoms & Phenotypes for Spindle Cell Sarcoma

MGI Mouse Phenotypes related to Spindle Cell Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.11 CCNE1 CDKN1B DES IL6 MDM2 NF2
2 cardiovascular system MP:0005385 10.09 ACTC1 CCNE1 CDKN1B DES IL6 KMT2B
3 homeostasis/metabolism MP:0005376 10.07 ACTC1 CDKN1B DES IL6 KMT2B KRT7
4 cellular MP:0005384 10.06 ACTC1 CCNE1 CDKN1B DES IL6 KMT2B
5 mortality/aging MP:0010768 10.02 ACTC1 CCNE1 CDKN1B DES IL6 KMT2B
6 muscle MP:0005369 9.73 ACTC1 CDKN1B DES IL6 MDM2 VIM
7 nervous system MP:0003631 9.56 CCNE1 CDKN1B IL6 KMT2B MDM2 NF2
8 neoplasm MP:0002006 9.55 CCNE1 CDKN1B IL6 MDM2 NF2
9 reproductive system MP:0005389 9.23 CCNE1 CDKN1B IL6 KMT2B MDM2 NF2

Drugs & Therapeutics for Spindle Cell Sarcoma

Drugs for Spindle Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 609)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lopinavir Approved Phase 4 192725-17-0 92727
2
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
3
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
4
Fosaprepitant Approved Phase 4 172673-20-0 219090
5
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
6
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
7
Dalteparin Approved Phase 4 9005-49-6
8
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
9
Enoxaparin Approved Phase 4 9005-49-6 772
10 Cytochrome P-450 CYP3A Inhibitors Phase 4
11 neurokinin A Phase 4
12 Neurokinin-1 Receptor Antagonists Phase 4
13
Substance P Phase 4 33507-63-0 44359816
14 Anticoagulants Phase 4
15 Heparin, Low-Molecular-Weight Phase 4
16 Fibrinolytic Agents Phase 4
17 calcium heparin Phase 4
18 Platelet Aggregation Inhibitors Phase 4
19 Antipyretics Phase 4
20
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 5281106 54677470
21
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
22
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
23
Irinotecan Approved, Investigational Phase 3 100286-90-6, 97682-44-5 60838
24
Morphine Approved, Investigational Phase 3 57-27-2 5288826
25
Nicotine Approved Phase 3 54-11-5 942 89594
26
Bortezomib Approved, Investigational Phase 3 179324-69-7 93860 387447
27
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
28
Abacavir Approved, Investigational Phase 2, Phase 3 136470-78-5 65140 441300
29
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
31
Sulfamethoxazole Approved Phase 3 723-46-6 5329
32
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
33
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
34
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
35
Varenicline Approved, Investigational Phase 3 249296-44-4 5310966
36
Dacarbazine Approved, Investigational Phase 2, Phase 3 4342-03-4 5351166
37
Epirubicin Approved Phase 3 56420-45-2 41867
38 Cranberry Approved, Investigational Phase 3
39 Grape Approved Phase 3
40
Cefazolin Approved Phase 3 25953-19-9 656510 33255
41
Denosumab Approved Phase 3 615258-40-7
42
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
43
Idarubicin Approved Phase 3 58957-92-9 42890
44
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
45
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
46
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
47
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
48
Emtricitabine Approved, Investigational Phase 3 143491-57-0 60877
49
Cetuximab Approved Phase 3 205923-56-4 56842117 2333
50
Nevirapine Approved Phase 3 129618-40-2 4463

Interventional clinical trials:

(show top 50) (show all 1642)
# Name Status NCT ID Phase Drugs
1 EpSSG (European Soft Tissue Sarcoma Study Group) Protocol for Non-Metastatic Rhabdomyosarcoma in Children Unknown status NCT00339118 Phase 4 doxorubicin, cytoxan
2 Optimizing Influenza Vaccination in Surgical Oncology Patients Unknown status NCT01698177 Phase 4
3 A Randomized Comparison of Protease Inhibitor-based Versus Non-nucleoside Reverse Transcriptase Inhibitor-based Antiretroviral Therapy for Initial Treatment of Individuals With AIDS-related Kaposi's Sarcoma in Sub-Saharan Africa Completed NCT00444379 Phase 4 Lopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir
4 A Prospective Randomized Trial Comparing the Response of HIV Kaposi's Sarcoma (KS) to HAART Versus the Combination of HAART and Chemotherapy (CXT) Completed NCT00380770 Phase 4 Generic HAART Triomune : d4T, 3TC, NVP;Generic HAART Triomune : d4T, 3TC, NVP and chemotherapy ABV
5 Prospective, Randomized Evaluation of Hyperbaric Oxygen Therapy on Wound Healing Following Management of Soft Tissue Sarcoma With Neo-Adjuvant Radiation and Surgical Resection Recruiting NCT03144206 Phase 4 Hyperbaric oxygen
6 Pharmacologic Interaction Between Ifosfamide and Aprepitant in Treated Patients With Soft Tissue Sarcoma Recruiting NCT03514381 Phase 4 Patients starting a treatment with Doxorubicin and Ifosfamide
7 Quality of Life in Patients With Non-adipocyte Soft Tissue Sarcoma Under Palliative Chemotherapy or Pazopanib — a Randomized, Controlled Trial Recruiting NCT03735758 Phase 4 Pazopanib or chemotherapy
8 An Open Label, Multicenter, Non-Comparative, Phase IV Study of Panitumumab to Characterize Its Safety, Tolerability and Activity in Indian Subjects With Previously Treated Wild-Type RAS (KRAS and NRAS), Metastatic Colorectal Cancer Recruiting NCT02301962 Phase 4 Panitumumab
9 Low Molecular Weight Heparin Versus Aspirin for Venous Thromboembolism Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
10 Registry of Retroperitoneal, Abdominal, Pelvic and Truncal Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet® to Evaluate the Safety and Feasibility Over 5 Years Not yet recruiting NCT04033081 Phase 4
11 Tacrolimus for the Treatment of Superficial Kaposiform Hemangioendothelioma and Tufted Angioma: a Single Arm Prospective Study Not yet recruiting NCT04056962 Phase 4 Tacrolimus ointment
12 A Registered Randomized, Double-Blind, Placebo-Controlled (2:1), Multi-Centered Clinical Trial of Anlotinib as a Treatment for Soft Tissue Sarcoma Unknown status NCT02449343 Phase 2, Phase 3 Anlotinib;Placebo
13 Phase III Study About the Effects of the Addition of Polychemotherapy to Adjuvant Radiotherapy in the Treatment of Non-Metastatic Uterine Sarcomas Unknown status NCT00162721 Phase 3 doxorubicin, ifosfamide, cisplatin
14 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Adriamycin, Bleomycin, and Vincristine (ABV) in the Treatment of Severe AIDS-Related Kaposi's Sarcoma Unknown status NCT00002318 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
15 A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS) Unknown status NCT01344018 Phase 3
16 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
17 EUROPEAN INTERGROUP COOPERATIVE EWING'S SARCOMA STUDY [EICESS 92] Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
18 Phase 3, Open Label, Multi-centre, Randomised Controlled International Study in Ewing Sarcoma Unknown status NCT00987636 Phase 3 Zoledronic acid;Busulfan;Treosulfan
19 Intensified Methotrexate, Vinblastine, Doxorubicin and Cisplatin +/-Panitumumab as First-line Treatment of Advanced Urothelial Carcinoma in Patients Without Harvey Nor Kirsten Rat Sarcoma Viral Oncogene Homolog Mutations. Phase II Study Unknown status NCT02818725 Phase 3 Chemotherapy;panitumumab
20 Phase III Study of The Role of Barrier Resection in Local Control in Treatment of Extremity Soft Tissue Sarcomas Unknown status NCT02120768 Phase 3
21 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
22 A Phase III Randomized Trial of Gemcitabine (NSC# 613327) Plus Docetaxel (NSC# 628503) Followed by Doxorubicin (NSC# 123127) Versus Observation for Uterus-Limited, High-Grade Uterine Leiomyosarcoma Unknown status NCT01533207 Phase 3 Docetaxel;Doxorubicin Hydrochloride;Gemcitabine Hydrochloride
23 A Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Ifosfamide Plus Paclitaxel in Chemotherapy-Naive Patients With Newly Diagnosed Stage I-IV, Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumors) of the Uterus, Fallopian Tube, Peritoneum or Ovary Unknown status NCT00954174 Phase 3 Carboplatin;Ifosfamide;Paclitaxel
24 A Double-Blind Randomized Placebo Controlled Trial for Prevention of Tuberculosis-Immune Reconstitution Inflammatory Syndrome With Non-Steroid Anti-Inflammatory Drugs (NSAIDs) in HIV-Infected Adults Unknown status NCT02060006 Phase 3 Meloxicam 7.5mg daily for 8 weeks
25 A Protocol For Nonmetastatic Rhabdomyosarcoma [RMS-2005] Unknown status NCT00379457 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate;vinorelbine tartrate
26 Prospective and Randomized Study of Fixed Versus Flexible Prophylactic Administration of Granulocyte Colony-Stimulating Factor (G-CSF) in Children With Cancer Unknown status NCT01987596 Phase 3
27 Comparing the Effectiveness of Combined Hyperthermia and External Beam Radiation (EBRT) Versus EBRT Alone in Treating Patients With Painful Bone Metastases Unknown status NCT01842048 Phase 3
28 A Randomized Double Blind Phase III Trial of Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior Therapy Completed NCT00753688 Phase 3 PAZOPANIB;Placebo
29 A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma. Completed NCT00002093 Phase 3 Daunorubicin (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
30 Use of Stealth Liposomal Doxorubicin HCl ( DOX-SL ) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma. Completed NCT00002147 Phase 3 Doxorubicin hydrochloride (liposomal)
31 A Multicenter, Randomized, Open-Label Phase 3 Study to Investigate the Efficacy and Safety of Aldoxorubicin Compared to Investigator's Choice in Subjects With Metastatic, Locally Advanced, or Unresectable Soft Tissue Sarcomas Who Either Relapsed or Were Refractory to Prior Non-Adjuvant Chemotherapy Completed NCT02049905 Phase 3 Aldoxorubicin;Investigator's Choice Treatment (Darcabazine, Pazopanib, Gemcitabine + Docetaxel, Doxorubicin, Ifosfamide)
32 Safety and Efficacy of (PN-152,243)/PN-196,444 in the Prevention of Thrombocytopenia Administered to Patients With High-Risk Sarcoma Receiving Intensive Chemotherapy (Adriamycin and Ifosfamide (AI)) Completed NCT00038311 Phase 3 PN-152,243)/PN-196,444
33 Double-Blind Randomized Evaluation of Clinical Benefits of DOXIL in Patients With AIDS-Related Kaposi's Sarcoma Treated With DOXIL or DaunoXome Completed NCT00002985 Phase 3 daunorubicin hydrochloride;pegylated liposomal doxorubicin hydrochloride
34 Open Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma Completed NCT00002319 Phase 3 Doxorubicin hydrochloride (liposomal)
35 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
36 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
37 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002105 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate
38 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
39 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
40 A Phase III Multicenter, International, Randomized, Double-blind, Placebo-controlled Study of Doxorubicin Plus Palifosfamide-tris vs. Doxorubicin Plus Placebo in Patients With Front-line Metastatic Soft Tissue Sarcoma. Completed NCT01168791 Phase 3 doxorubicin in combination with palifosfamide-tris;doxorubicin in combination with placebo
41 A Randomized Phase III Trial Comparing Trabectedin (Yondelis®) to the Best Supportive Care in Patients With Advanced Soft Tissue Sarcoma Completed NCT02672527 Phase 3 Trabectedin;Dexamethasone
42 Randomised Trial Of Single Agent Doxorubicin Versus Doxorubicin Plus Ifosfamide In The First Line Treatment Of Advanced Or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
43 Phase III Prospective Randomized Trial of Pre-Operative Intensity Modulated Radiation Therapy (IMRT) Plus Surgery Versus Surgery Alone For Primary Retroperitoneal Sarcoma Completed NCT00131898 Phase 3
44 Phase III Randomized Study of Adjuvant Pelvic Radiotherapy Versus Observation Alone in Patients With Completely Resected, Stage I or II, High-Grade Uterine Sarcoma Completed NCT00002459 Phase 3
45 Ph III Random Trial of 120-Min Infusion Gemcitabine v. 90-Min Infusion Gemcitabine + Docetaxel in Unresectable Soft Tissue Sarcoma: A Multi-Disciplinary Trial of the North Amer. Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00142571 Phase 3 Gemcitabine;Docetaxel
46 A Phase III Randomized Placebo Controlled and Double Blinded Study of IM862 for Patients With Muco-Cutaneous AIDS Associated Kaposi's Sarcoma Completed NCT00002445 Phase 3 IM862
47 A Phase III Randomized Study of Preoperative Radiation Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcomas (RPS) Completed NCT00091351 Phase 3
48 Randomized Study Comparing Neoadjuvant Chemotherapy Etoposide + Ifosfamide + Adriamycin (EIA) Combined With Regional Hyperthermia (RHT) Versus Neoadjuvant Chemotherapy Alone in the Treatment of High-Risk Soft Tissue Sarcomas in Adults Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
49 A Randomized Phase 3, Multicenter, Open-Label Study Comparing TH-302 in Combination With Doxorubicin vs. Doxorubicin Alone in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma Completed NCT01440088 Phase 3 TH-302 in Combination with Doxorubicin;Doxorubicin
50 A Randomized Study of the Effect of Adjuvant Chemotherapy With Doxorubicin and Ifosfamide With Mesna in the Treatment of High-Grade Adult Extremity Soft Tissue Sarcoma Completed NCT00001300 Phase 3 doxorubicin;ifosfamide;mesna

Search NIH Clinical Center for Spindle Cell Sarcoma

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Ifosfamide
Mitoxantrone
Mitoxantrone Hydrochloride
Thiotepa

Cochrane evidence based reviews: sarcoma

Genetic Tests for Spindle Cell Sarcoma

Anatomical Context for Spindle Cell Sarcoma

MalaCards organs/tissues related to Spindle Cell Sarcoma:

41
Bone, Lung, Myeloid, Breast, Liver, Kidney, Uterus

Publications for Spindle Cell Sarcoma

Articles related to Spindle Cell Sarcoma:

(show top 50) (show all 30388)
# Title Authors PMID Year
1
Carcinosarcoma in the pouch of douglas. 9 38
19484471 2010
2
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. 9 38
17343592 2007
3
Primary intraabdominal synovial sarcoma: a case report. 9 38
15800696 2005
4
An ultrastructural, immunohistochemical, and cytogenetical study of a monophasic pulmonary synovial sarcoma: implications of the frequent ultrastructure of oligocilia and concentric membranous bodies with positive immunostaining for VS38c and MEF2. 9 38
12907368 2003
5
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors. 9 38
11570907 2001
6
Malignant mixed müllerian tumors of the ovary. 9 38
10820916 2000
7
Corticomedullary tumors of the adrenal glands. Report of two cases. Association of corticomedullary tumor with spindle cell sarcoma. 9 38
9122025 1996
8
Primary retroperitoneal synovial sarcoma. 9 38
7849384 1994
9
Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. 9 38
1718079 1991
10
The role of radiation therapy and margin width in localized soft-tissue sarcoma: Analysis from the US Sarcoma Collaborative. 38
31172531 2019
11
One shot NEPA plus dexamethasone to prevent multiple-day chemotherapy in sarcoma patients. 38
30762142 2019
12
Primary adrenal gland epithelioid sarcoma: A case report and literature review. 38
31087789 2019
13
Hanging Undifferentiated Embryonal Sarcoma of the Liver in Adult: an Unusual Presentation of an Aggressive Tumor. 38
29779073 2019
14
Recurrence patterns after resection of retroperitoneal sarcomas: An eight-institution study from the US Sarcoma Collaborative. 38
31246290 2019
15
Primary Orbital Synovial Sarcoma Mimicking a Periocular Cyst. 38
30624245 2019
16
Basic Knowledge in Soft Tissue Sarcoma. 38
31236647 2019
17
Cancer-testis antigens in canine histiocytic sarcoma and other malignancies. 38
30854786 2019
18
Vascular modulation through exercise improves chemotherapy efficacy in Ewing sarcoma. 38
31136074 2019
19
A germline BARD1 mutation in a patient with Ewing Sarcoma: Implications for familial testing and counseling. 38
31157509 2019
20
Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy. 38
31207107 2019
21
Local recurrence of Ewing sarcoma: Is wide excision an acceptable treatment? 38
31286523 2019
22
Histiocytic Sarcoma and Hemangiosarcoma Update. 38
31186126 2019
23
Lymph Node Sampling and Survival in Child and Adolescent Extremity Soft-Tissue Sarcoma. 38
31028942 2019
24
Acetabular myeloid sarcoma as an extramedullary presentation of chronic myeloid leukaemia blast crisis. 38
31172503 2019
25
The opportunities and shortcomings of using big data and national databases for sarcoma research. 38
31090929 2019
26
Pleomorphic undifferentiated aortic sarcoma presenting as persistent endoleak after endovascular aneurysm repair. 38
31334403 2019
27
Successful treatment for Kaposi sarcoma inflammatory cytokine syndrome in a severe CD4+ lymphocytopenic HIV patient. 38
31356257 2019
28
Primary orbital low-grade fibromyxoid sarcoma. 38
31436218 2019
29
Clear Cell Sarcoma-Like Tumor of the Gastrointestinal Tract. 38
29623567 2019
30
Myeloid Sarcoma of the Parotid Gland and Stomach Presenting with Obstructive Jaundice: A Rare Presentation 38
30993960 2019
31
[YWHAE rearrangement high grade endometrial stromal sarcoma: report of a case]. 38
31422597 2019
32
Sarcoma with MGA-NUTM1 fusion in the lung: an emerging entity. 38
31385070 2019
33
Use of Cardioprotective Dexrazoxane Is Associated with Increased Myelotoxicity in Anthracycline-Treated Soft-Tissue Sarcoma Patients. 38
31390619 2019
34
[The importance of radiology in bone sarcoma diagnostics : Initial and advanced diagnostics]. 38
31392388 2019
35
Intimal sarcoma in an ascending aortic Dacron graft mimicking a thrombus. 38
31369080 2019
36
Changing odds of survival over time among patients undergoing surgical resection of extremity soft tissue sarcoma. 38
31042013 2019
37
Stanmore noninvasive extendible endoprosthesis in the treatment of bone sarcoma in the preadolescent. 38
31093984 2019
38
Perilipin 1 Expression Differentiates Liposarcoma from Other Types of Soft Tissue Sarcoma. 38
31125552 2019
39
Adult Primary Peripheral PNET/Ewing's Sarcoma of the Cervical and Thoracic Spine. 38
31366545 2019
40
Targeted therapy of BRAF V600E-mutant histiocytic sarcoma: a case report and review of the literature. 38
31376203 2019
41
Primary pulmonary synovial sarcoma with calcification: A case report. 38
31426131 2019
42
PAX8-positive Biphasic Synovial Sarcoma Expressing Hormonal Receptors. 38
28248726 2019
43
ST-Segment Elevation Myocardial Infarction Due to Right Coronary Artery Compression by Cardiac Synovial Sarcoma. 38
31422086 2019
44
Synovial Sarcoma of the Nerve-Clinical and Pathological Features: Case Series and Systematic Review. 38
31435657 2019
45
Successful Full-term Pregnancies After High-dose Pelvic Radiotherapy for Ewing Sarcoma: A Case Report. 38
31415018 2019
46
PET-CT imaging features that differentiate between positive and negative EWSR1 translocation in Ewing sarcoma. 38
31107830 2019
47
FDG PET/CT in a Case of Primary Pulmonary Ewing Sarcoma. 38
31274619 2019
48
Getting away with phase transition: NPM1-mutated bone myeloid sarcoma mimicking Ewing sarcoma. 38
30879096 2019
49
Targeting glycolysis through inhibition of lactate dehydrogenase impairs tumor growth in preclinical models of Ewing sarcoma. 38
31431459 2019
50
Outcomes of extraskeletal vs. skeletal Ewing sarcoma patients treated with standard chemotherapy protocol. 38
31429039 2019

Variations for Spindle Cell Sarcoma

ClinVar genetic disease variations for Spindle Cell Sarcoma:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 NF2 NM_000268.3(NF2): c.583_589del (p.His195fs) deletion Pathogenic 22:30051649-30051655 22:29655660-29655666
2 MGA ; NUTM1 der(15)t(5: 15)(q23.2;q15.1) Translocation Pathogenic
3 subset of 62 genes:ACTC1 ; MEIS2 ; SPRED1 GRCh37/hg19 15q14-15.1 chr15: 34638237..42057083 complex variant complex Pathogenic 15:34638237-42057083 :0-0

Expression for Spindle Cell Sarcoma

Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for Spindle Cell Sarcoma

Pathways related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.55 VIM NTRK3 MUC1 MDM2 IL6 DES
2
Show member pathways
12.44 MDM2 IL6 CDKN1B CCNE1
3 12.2 VIM MDM2 CDKN1B CCNE1
4 12.14 VIM MDM2 CDKN1B CCNE1
5
Show member pathways
12 IL6 DES ACTC1
6 11.92 MDM2 IL6 CCNE1
7 11.9 NTRK3 MDM2 CDKN1B
8
Show member pathways
11.84 MDM2 IL6 CDKN1B
9 11.77 VIM IL6 CDKN1B
10 11.73 VIM MUC1 IL6
11
Show member pathways
11.67 VIM KRT7 DES
12 11.63 MDM2 IL6 CDKN1B
13 11.59 VIM NF2 MUC1 KRT7 DES ACTC1
14 11.44 MDM2 CDKN1B CCNE1
15 11.3 NF2 MDM2 CDKN1B CCNE1
16 11.29 VIM DES ACTC1
17 11.08 MDM2 CDKN1B CCNE1

GO Terms for Spindle Cell Sarcoma

Cellular components related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.36 VIM S100B NTRK3 NF2 MUC1 MDM2

Biological processes related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.67 MDM2 IL6 CDKN1B ACTC1
2 positive regulation of gene expression GO:0010628 9.55 VIM NTRK3 MDM2 IL6 ACTC1
3 intermediate filament organization GO:0045109 9.46 VIM DES
4 lens fiber cell differentiation GO:0070306 9.43 NTRK3 NF2
5 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.43 MUC1 MDM2 CDKN1B
6 cellular response to antibiotic GO:0071236 9.4 MDM2 CDKN1B
7 positive regulation of cell cycle GO:0045787 9.32 MDM2 CDKN1B
8 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
9 positive regulation of cell proliferation GO:0008284 9.02 S100B NTRK3 MDM2 IL6 CDKN1B

Molecular functions related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.73 VIM S100B NTRK3 NF2 MUC1 MDM2
2 p53 binding GO:0002039 8.8 NTRK3 MUC1 MDM2

Sources for Spindle Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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