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MCID: SPN035
MIFTS: 53

Spindle Cell Sarcoma

Categories: Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Spindle Cell Sarcoma

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MalaCards integrated aliases for Spindle Cell Sarcoma:

Name: Spindle Cell Sarcoma 12 6 15
Sarcoma 43 71
Sarcoma, Spindle Cell 71
Sarcoma Spindle Cell 54
Sarcoma - Category 71

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4235
MeSH 43 D012509
NCIt 49 C27005
SNOMED-CT 67 9801004
UMLS 71 C0205945 C1261473 C1299262
Sources

Summaries for Spindle Cell Sarcoma

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Disease Ontology : 12 A sarcoma that results in cells that are spindle-shaped. They are usually resistant to radiation therapy.

MalaCards based summary : Spindle Cell Sarcoma, also known as sarcoma, is related to ewing sarcoma of bone and reticulum cell sarcoma. An important gene associated with Spindle Cell Sarcoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Cytoskeletal Signaling. The drugs Lopinavir and Lamivudine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and myeloid, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 74 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

Sources

Related Diseases for Spindle Cell Sarcoma

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Diseases related to Spindle Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2178)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma of bone 34.1 VIM DES
2 reticulum cell sarcoma 33.9 VIM MUC1 DES ACTC1
3 epithelioid sarcoma 33.9 VIM MUC1 KRT7 CD34
4 pancreas sarcoma 33.8 SERPINA3 MDM2
5 alveolar soft part sarcoma 33.8 VIM MYOG DES ACTC1
6 extraskeletal ewing sarcoma 33.8 VIM MUC1 DES
7 epithelioid cell synovial sarcoma 33.8 SSX2 SSX1
8 gallbladder sarcoma 33.7 MYOG DES
9 central epithelioid sarcoma 33.6 VIM KRT7 CD34
10 vulvar proximal-type epithelioid sarcoma 33.6 VIM KRT7 CD34
11 meninges sarcoma 33.6 SSX2 SS18
12 kidney clear cell sarcoma 33.4 SSX1 NTRK3 CCNB3
13 undifferentiated embryonal sarcoma of the liver 33.4 SERPINA3 MYOG MDM2
14 vagina sarcoma 33.2 VIM MYOG CD34
15 endometrial stromal sarcoma 33.2 VIM S100B DES CCNB3 ACTC1
16 retroperitoneal sarcoma 33.1 SSX2 MYOG MDM2 CD34
17 dendritic cell tumor 33.1 VIM S100B NCOA2 MUC1 ACTC1
18 botryoid rhabdomyosarcoma 33.1 MYOG DES ACTC1
19 lung sarcoma 32.9 SSX2 SSX1 SERPINA3 CD34
20 uterine carcinosarcoma 32.9 VIM MUC1 MDM2 DES
21 kidney sarcoma 32.8 SSX2 SS18 CCNB3
22 desmoplastic small round cell tumor 32.5 VIM MUC1 DES
23 embryonal sarcoma 32.5 VIM SERPINA3 S100B MYOG MDM2 DES
24 biphasic synovial sarcoma 32.5 VIM SSX2 SSX1 SS18 MUC1 DES
25 reticulosarcoma 32.4 SERPINA3 MUC1 CDKN1B
26 rhabdoid cancer 32.4 SSX2 SS18 MYOG
27 giant cell glioblastoma 32.3 SERPINA3 MDM2 CD34
28 breast angiosarcoma 32.3 VEGFA CD34
29 bednar tumor 32.2 VIM S100B
30 adenosarcoma 32.1 VIM SERPINA3 DES ACTC1
31 monophasic synovial sarcoma 32.0 VIM SSX2 SSX1 SS18 MUC1 KRT7
32 prostate angiosarcoma 32.0 VEGFA CD34
33 mesothelioma, malignant 31.9 VIM NF2 MUC1 KRT7 DES
34 chordoma 31.5 VIM VEGFA SERPINA3 S100B MUC1 KRT7
35 wilms tumor 1 31.1 VEGFA SERPINA3 MYOG KRT7 CD34
36 pneumothorax 31.1 VIM MUC1 ACTC1
37 soft tissue sarcoma 30.9 VEGFA MDM2
38 meningioma, radiation-induced 30.9 VIM S100B NF2 MUC1
39 rare tumor 30.9 NF2 DES ACTC1
40 rhabdoid tumor predisposition syndrome 1 30.8 VIM MUC1 DES ACTC1
41 leiomyoma 30.8 VIM DES CD34 ACTC1
42 malignant mesenchymoma 30.8 SSX2 SERPINA3 MYOG MDM2 DES CD34
43 benign mesothelioma 30.8 KRT7 CD34
44 pyogenic granuloma 30.7 CD34 ACTC1
45 leukemia, acute myeloid 30.6 VEGFA SERPINA3 NCOA2 MDM2 CDKN1B CD34
46 retroperitoneal fibrosis 30.5 VIM MDM2
47 secretory meningioma 30.5 VIM SERPINA3 NF2 MUC1 KRT7
48 myopericytoma 30.5 S100B ACTC1
49 osteochondroma 30.5 VIM S100B NCOA2
50 bacillary angiomatosis 30.4 VEGFA CD34

Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to Spindle Cell Sarcoma
Sources

Symptoms & Phenotypes for Spindle Cell Sarcoma

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MGI Mouse Phenotypes related to Spindle Cell Sarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.9 ACTC1 CCNB3 CD34 CDKN1B DES KRT7
2 homeostasis/metabolism MP:0005376 9.77 ACTC1 CD34 CDKN1B DES KRT7 MDM2
3 integument MP:0010771 9.28 CD34 CDKN1B MDM2 MYOG NCOA2 NF2
Sources

Drugs & Therapeutics for Spindle Cell Sarcoma

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Drugs for Spindle Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 595)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lopinavir Approved Phase 4 192725-17-0 92727
2
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
3
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
4
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
5
Tranexamic Acid Approved Phase 4 1197-18-8 5526
6
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
7
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
8
Dalteparin Approved Phase 4 9005-49-6
9
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
10
Enoxaparin Approved Phase 4 9005-49-6 772
11 Cytochrome P-450 CYP3A Inhibitors Phase 4
12 Hemostatics Phase 4
13 Antifibrinolytic Agents Phase 4
14 Coagulants Phase 4
15 Anticoagulants Phase 4
16 Fibrinolytic Agents Phase 4
17 Heparin, Low-Molecular-Weight Phase 4
18 calcium heparin Phase 4
19 Platelet Aggregation Inhibitors Phase 4
20 Antipyretics Phase 4
21
Morphine Approved, Investigational Phase 3 57-27-2 5288826
22
Meloxicam Approved, Vet_approved Phase 3 71125-38-7 54677470 5281106
23
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
24
Irinotecan Approved, Investigational Phase 3 97682-44-5, 100286-90-6 60838
25
Nicotine Approved Phase 3 54-11-5 942 89594
26
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
27
Abacavir Approved, Investigational Phase 2, Phase 3 136470-78-5 441300 65140
28
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
29
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
30
Sulfamethoxazole Approved Phase 3 723-46-6 5329
31
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
32
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
33
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
34
Varenicline Approved, Investigational Phase 3 249296-44-4 5310966
35
Epirubicin Approved Phase 3 56420-45-2 41867
36
Palbociclib Approved, Investigational Phase 3 571190-30-2 5005498 11431660 5330286
37
Olaparib Approved Phase 3 763113-22-0 23725625
38
Ceritinib Approved Phase 3 1032900-25-6
39
Denosumab Approved Phase 3 615258-40-7
40
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
41
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
42
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
43
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
44
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
45
Idarubicin Approved Phase 3 58957-92-9 42890
46
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
47
Daunorubicin Approved Phase 3 20830-81-3 30323
48
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
49
Bortezomib Approved, Investigational Phase 3 179324-69-7 387447 93860
50
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314

Interventional clinical trials:

(show top 50) (show all 1790)
# Name Status NCT ID Phase Drugs
1 EpSSG (European Soft Tissue Sarcoma Study Group) Protocol for Non-Metastatic Rhabdomyosarcoma in Children Unknown status NCT00339118 Phase 4 doxorubicin, cytoxan
2 Optimizing Influenza Vaccination in Surgical Oncology Patients Unknown status NCT01698177 Phase 4
3 A Randomized Comparison of Protease Inhibitor-based Versus Non-nucleoside Reverse Transcriptase Inhibitor-based Antiretroviral Therapy for Initial Treatment of Individuals With AIDS-related Kaposi's Sarcoma in Sub-Saharan Africa Completed NCT00444379 Phase 4 Lopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir
4 A Prospective Randomized Trial Comparing the Response of HIV Kaposi's Sarcoma (KS) to HAART Versus the Combination of HAART and Chemotherapy (CXT) Completed NCT00380770 Phase 4 Generic HAART Triomune : d4T, 3TC, NVP;Generic HAART Triomune : d4T, 3TC, NVP and chemotherapy ABV
5 Prospective, Randomized Evaluation of Hyperbaric Oxygen Therapy on Wound Healing Following Management of Soft Tissue Sarcoma With Neo-Adjuvant Radiation and Surgical Resection Recruiting NCT03144206 Phase 4 Hyperbaric oxygen
6 Pharmacologic Interaction Between Ifosfamide and Aprepitant in Treated Patients With Soft Tissue Sarcoma Recruiting NCT03514381 Phase 4 Patients starting a treatment with Doxorubicin and Ifosfamide
7 Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule Recruiting NCT04223583 Phase 4 Anlotinib Hydrochloride
8 Quality of Life in Patients With Non-adipocyte Soft Tissue Sarcoma Under Palliative Chemotherapy or Pazopanib — a Randomized, Controlled Trial Recruiting NCT03735758 Phase 4 pazopanib or guideline conform chemotherapy
9 Tacrolimus for the Treatment of Superficial Kaposiform Hemangioendothelioma and Tufted Angioma: a Single Arm Prospective Study Recruiting NCT04056962 Phase 4 Tacrolimus ointment
10 An Open Label, Multicenter, Non-Comparative, Phase IV Study of Panitumumab to Characterize Its Safety, Tolerability and Activity in Indian Subjects With Previously Treated Wild-Type RAS (KRAS and NRAS), Metastatic Colorectal Cancer Recruiting NCT02301962 Phase 4 Panitumumab
11 Tranexamic Acid in Radical Resection and Endoprosthetic Reconstruction: A Randomized Controlled Trial Recruiting NCT04347122 Phase 4 Tranexamic Acid (TXA)
12 Safety and Efficacy of Low-dose Sirolimus to Kaposiform Hemangioendothelioma:A Prospective, Randomized Open Trial Recruiting NCT04077515 Phase 4 Sirolimus(0.8mg/m2);Sirolimus(0.7mg/m2)
13 Low Molecular Weight Heparin Versus Aspirin for Venous Thromboembolism Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
14 Registry of Retroperitoneal, Abdominal, Pelvic and Truncal Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet® to Evaluate the Safety and Feasibility Over 5 Years Not yet recruiting NCT04033081 Phase 4
15 A Registered Randomized, Double-Blind, Placebo-Controlled (2:1), Multi-Centered Clinical Trial of Anlotinib as a Treatment for Soft Tissue Sarcoma Unknown status NCT02449343 Phase 2, Phase 3 Anlotinib;Placebo
16 Phase III Study About the Effects of the Addition of Polychemotherapy to Adjuvant Radiotherapy in the Treatment of Non-Metastatic Uterine Sarcomas Unknown status NCT00162721 Phase 3 doxorubicin, ifosfamide, cisplatin
17 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Adriamycin, Bleomycin, and Vincristine (ABV) in the Treatment of Severe AIDS-Related Kaposi's Sarcoma Unknown status NCT00002318 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
18 A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS) Unknown status NCT01344018 Phase 3
19 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
20 MULTICENTER RANDOMIZED, OPEN-LABEL PHASE II/III STUDY, TO COMPARE EFFICACY OF NBTXR3 IMPLANTED AS INTRATUMOR INJECTION AND ACTIVATED BY RADIOTHERAPY, VERSUS RADIOTHERAPY ALONE IN PATIENTS WITH LOCALLY ADVANCED SOFT TISSUE SARCOMA (EXTREMITY AND TRUNK WALL) Unknown status NCT02379845 Phase 2, Phase 3
21 EUROPEAN INTERGROUP COOPERATIVE EWING'S SARCOMA STUDY [EICESS 92] Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
22 Intensified Methotrexate, Vinblastine, Doxorubicin and Cisplatin +/-Panitumumab as First-line Treatment of Advanced Urothelial Carcinoma in Patients Without Harvey Nor Kirsten Rat Sarcoma Viral Oncogene Homolog Mutations. Phase II Study Unknown status NCT02818725 Phase 3 Chemotherapy;panitumumab
23 Phase III Study of The Role of Barrier Resection in Local Control in Treatment of Extremity Soft Tissue Sarcomas Unknown status NCT02120768 Phase 3
24 European Ewing Tumour Working Initiative of National Groups Ewing Tumour Studies 1999 (EURO-E.W.I.N.G.99) Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
25 Risk-Based Treatment for Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) in Patients Under 30 Years of Age Unknown status NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
26 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
27 A Double-Blind Randomized Placebo Controlled Trial for Prevention of Tuberculosis-Immune Reconstitution Inflammatory Syndrome With Non-Steroid Anti-Inflammatory Drugs (NSAIDs) in HIV-Infected Adults Unknown status NCT02060006 Phase 3 Meloxicam 7.5mg daily for 8 weeks
28 A Protocol For Nonmetastatic Rhabdomyosarcoma [RMS-2005] Unknown status NCT00379457 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate;vinorelbine tartrate
29 Prospective and Randomized Study of Fixed Versus Flexible Prophylactic Administration of Granulocyte Colony-Stimulating Factor (G-CSF) in Children With Cancer Unknown status NCT01987596 Phase 3
30 Comparing the Effectiveness of Combined Hyperthermia and External Beam Radiation (EBRT) Versus EBRT Alone in Treating Patients With Painful Bone Metastases Unknown status NCT01842048 Phase 3
31 Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) Versus VAC Alternating With Vincristine and Irinotecan (VI) for Patients With Intermediate-Risk Rhabdomyosarcoma (RMS) Unknown status NCT00354835 Phase 3 Irinotecan Hydrochloride;Cyclophosphamide;Vincristine Sulfate
32 A Randomized Double Blind Phase III Trial of Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior Therapy Completed NCT00753688 Phase 3 PAZOPANIB;Placebo
33 A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma. Completed NCT00002093 Phase 3 Daunorubicin (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
34 Use of Stealth Liposomal Doxorubicin HCl ( DOX-SL ) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma. Completed NCT00002147 Phase 3 Doxorubicin hydrochloride (liposomal)
35 A Multicenter, Randomized, Open-Label Phase 3 Study to Investigate the Efficacy and Safety of Aldoxorubicin Compared to Investigator's Choice in Subjects With Metastatic, Locally Advanced, or Unresectable Soft Tissue Sarcomas Who Either Relapsed or Were Refractory to Prior Non-Adjuvant Chemotherapy Completed NCT02049905 Phase 3 Aldoxorubicin;Investigator's Choice Treatment (Darcabazine, Pazopanib, Gemcitabine + Docetaxel, Doxorubicin, Ifosfamide)
36 Safety and Efficacy of (PN-152,243)/PN-196,444 in the Prevention of Thrombocytopenia Administered to Patients With High-Risk Sarcoma Receiving Intensive Chemotherapy (Adriamycin and Ifosfamide (AI)) Completed NCT00038311 Phase 3 PN-152,243)/PN-196,444
37 Double-Blind Randomized Evaluation of Clinical Benefits of DOXIL in Patients With AIDS-Related Kaposi's Sarcoma Treated With DOXIL or DaunoXome Completed NCT00002985 Phase 3 daunorubicin hydrochloride;pegylated liposomal doxorubicin hydrochloride
38 Open Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma Completed NCT00002319 Phase 3 Doxorubicin hydrochloride (liposomal)
39 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
40 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
41 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002105 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate
42 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
43 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
44 A Phase III Multicenter, International, Randomized, Double-blind, Placebo-controlled Study of Doxorubicin Plus Palifosfamide-tris vs. Doxorubicin Plus Placebo in Patients With Front-line Metastatic Soft Tissue Sarcoma. Completed NCT01168791 Phase 3 doxorubicin in combination with palifosfamide-tris;doxorubicin in combination with placebo
45 A Randomized Phase III Trial Comparing Trabectedin (Yondelis®) to the Best Supportive Care in Patients With Advanced Soft Tissue Sarcoma Completed NCT02672527 Phase 3 Trabectedin;Dexamethasone
46 Phase III Prospective Randomized Trial of Pre-Operative Intensity Modulated Radiation Therapy (IMRT) Plus Surgery Versus Surgery Alone For Primary Retroperitoneal Sarcoma Completed NCT00131898 Phase 3
47 Randomised Trial Of Single Agent Doxorubicin Versus Doxorubicin Plus Ifosfamide In The First Line Treatment Of Advanced Or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
48 Ph III Random Trial of 120-Min Infusion Gemcitabine v. 90-Min Infusion Gemcitabine + Docetaxel in Unresectable Soft Tissue Sarcoma: A Multi-Disciplinary Trial of the North Amer. Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00142571 Phase 3 Gemcitabine;Docetaxel
49 Phase III Randomized Study of Adjuvant Pelvic Radiotherapy Versus Observation Alone in Patients With Completely Resected, Stage I or II, High-Grade Uterine Sarcoma Completed NCT00002459 Phase 3
50 A Phase III Randomized Placebo Controlled and Double Blinded Study of IM862 for Patients With Muco-Cutaneous AIDS Associated Kaposi's Sarcoma Completed NCT00002445 Phase 3 IM862

Search NIH Clinical Center for Spindle Cell Sarcoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ifosfamide
Mitoxantrone
Mitoxantrone Hydrochloride
Thiotepa

Cochrane evidence based reviews: sarcoma

Sources

Genetic Tests for Spindle Cell Sarcoma

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Sources

Anatomical Context for Spindle Cell Sarcoma

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MalaCards organs/tissues related to Spindle Cell Sarcoma:

40
Bone, Lung, Myeloid, Breast, Liver, Kidney, Uterus
Sources

Publications for Spindle Cell Sarcoma

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Articles related to Spindle Cell Sarcoma:

(show top 50) (show all 30402)
# Title Authors PMID Year
1
Carcinosarcoma in the pouch of douglas. 61 54
19484471 2010
2
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. 54 61
17343592 2007
3
Primary intraabdominal synovial sarcoma: a case report. 54 61
15800696 2005
4
An ultrastructural, immunohistochemical, and cytogenetical study of a monophasic pulmonary synovial sarcoma: implications of the frequent ultrastructure of oligocilia and concentric membranous bodies with positive immunostaining for VS38c and MEF2. 61 54
12907368 2003
5
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors. 54 61
11570907 2001
6
Malignant mixed müllerian tumors of the ovary. 61 54
10820916 2000
7
Corticomedullary tumors of the adrenal glands. Report of two cases. Association of corticomedullary tumor with spindle cell sarcoma. 61 54
9122025 1996
8
Primary retroperitoneal synovial sarcoma. 54 61
7849384 1994
9
Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. 61 54
1718079 1991
10
Antinociceptive activity of Schinus terebinthifolia leaf lectin (SteLL) in sarcoma 180-bearing mice. 61
32416247 2020
11
CIC-rearranged round cell (Ewing-like) sarcoma of the uterus: Review of the literature. 61
32529020 2020
12
Gastric Ewing Sarcoma identified on a Meckel's scan. 61
32577140 2020
13
Case report of intra-articular synovial sarcoma in the hip joint. 61
32577142 2020
14
Malignant primitive epithelioid sarcoma with features of rhabdoid tumor presenting in utero with diffusely metastatic disease. 61
32551227 2020
15
French Sarcoma Group proposals for management of sarcoma patients during the COVID-19 outbreak. 61
32278878 2020
16
A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma. 61
32141887 2020
17
Kaposi sarcoma in HIV-negative men who have sex with men: a case series of nonepidemic Kaposi sarcoma. 61
31755130 2020
18
Isolated limb perfusion is an effective treatment modality for locally advanced Kaposi sarcoma of the extremities. 61
32359920 2020
19
Alveolar soft part sarcoma: A distinct cytomorphology and characteristic TFE3 staining. 61
32315502 2020
20
Novel therapeutic options for alveolar soft part sarcoma: antiangiogenic therapy, immunotherapy and beyond. 61
32541316 2020
21
Cabozantinib as an emerging treatment for sarcoma. 61
32541320 2020
22
Immunotherapy in sarcoma: combinations or single agents? In whom? 61
32541322 2020
23
Enhancing rotational placement of reconstruction prostheses of the distal femur after sarcoma resection. 61
32507678 2020
24
Limb preserving surgery for soft-tissue sarcoma in the hand: a retrospective study of 51 cases. 61
31973665 2020
25
SMARCA4-deficient uterine sarcoma: A case report and a concise review. 61
32551237 2020
26
The natural history of epithelioid sarcoma. A retrospective multicentre case-series within the Italian Sarcoma Group. 61
32307188 2020
27
Granulocytic Sarcoma: A Rare Cause of Wrist Pain. 61
32149843 2020
28
Undifferentiated embryonal sarcoma of liver: Paradoxical imaging appearance. 61
32489512 2020
29
Right Atrial Intimal Sarcoma on 18F-FDG PET/CT. 61
32404706 2020
30
Tumor-induced osteomalacia in an adolescent with an undifferentiated embryonal sarcoma of the liver. 61
32383825 2020
31
Advances in image enhancement for sarcoma surgery. 61
32247870 2020
32
Role of Metastatic Site Irradiation in Pediatric Patients With Metastatic Ewing Sarcoma. 61
32079986 2020
33
Primary renal Ewing Sarcoma masquerading as Wilms in an adolescent female. 61
32322516 2020
34
A novel MBTD1-PHF1 gene fusion in endometrial stromal sarcoma: A case report and literature review. 61
32237188 2020
35
Primary pulmonary artery sarcoma in the pediatric patient: Review of literature and a case report. 61
32477441 2020
36
PET with 18F-Fluorodeoxyglucose/Computed Tomography in the Management of Pediatric Sarcoma. 61
32498989 2020
37
Low-Grade Myofibroblastic Sarcoma Demonstrated on 99mTc-MDP Bone Scan and 18F-FDG PET/CT. 61
32433178 2020
38
18F-FDG PET/CT in Follicular Dendritic Cell Sarcoma With Paraneoplastic Pemphigus as the First Manifestation. 61
32371617 2020
39
Kaposi's Sarcoma Occurring in HIV Infection Controlled on HAART. 61
31751529 2020
40
Outcomes of palliative-intent surgery in retroperitoneal sarcoma-Results from the US Sarcoma Collaborative. 61
32167587 2020
41
Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications. 61
31995235 2020
42
Rb and p53-Deficient Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma Require Skp2 for Survival. 61
32161142 2020
43
Desmoid tumor mimics local recurrence of extremity sarcoma on MRI. 61
32212166 2020
44
Primary bone sarcoma with BCOR internal tandem duplication. 61
31900635 2020
45
Donor-derived acute promyelocytic leukemia presenting as myeloid sarcoma in a transplanted kidney. 61
32523036 2020
46
Primary cutaneous localized/clearly-outlined true histiocytic sarcoma: Two long-term follow-up cases. 61
32180261 2020
47
Modeling the Tumor Microenvironment and Pathogenic Signaling in Bone Sarcoma. 61
32057288 2020
48
Unusual Mimicker of the Carotid Body Tumor: Synovial Sarcoma of the Carotid Space. 61
32209939 2020
49
Detection of synovial sarcoma with an atypical fusion transcript by using SS18-SSX and SSX antibodies. 61
32564448 2020
50
Allergic contact dermatitis caused by timolol eyedrop application for classic Kaposi sarcoma. 61
32542767 2020
Sources

Variations for Spindle Cell Sarcoma

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ClinVar genetic disease variations for Spindle Cell Sarcoma:

6 ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NF2 NM_000268.4(NF2):c.583_589del (p.His195fs)deletion Pathogenic 585330 rs1569294187 22:30051646-30051652 22:29655657-29655663
2 MGA , NUTM1 der(15)t(5:15)(q23.2;q15.1)Translocation Pathogenic 585331
3 subset of 62 genes: ACTC1 , MEIS2 , SPRED1 GRCh37/hg19 15q14-15.1 chr15:34638237..42057083 complex variantcomplex Pathogenic 585332 15:34638237-42057083
Sources

Expression for Spindle Cell Sarcoma

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Search GEO for disease gene expression data for Spindle Cell Sarcoma.
Sources

Pathways for Spindle Cell Sarcoma

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Pathways related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Transcriptional misregulation in cancer 36
11.64 SSX2 SSX1 SS18 MDM2 CDKN1B
2
Cytoskeletal Signaling 4
11.59 VIM NF2 MUC1 KRT7 DES ACTC1
3
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.48 MYOG DES CD34
4
Neural Stem Cells and Lineage-specific Markers 64
11.33 VIM VEGFA S100B
5
Striated Muscle Contraction 65 1
11.19 VIM DES ACTC1
Sources

GO Terms for Spindle Cell Sarcoma

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Cellular components related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.83 VIM VEGFA S100B NTRK3 NF2 NCOA2
2 nucleus GO:0005634 9.53 VIM SSX2 SSX1 SS18 SERPINA3 S100B

Biological processes related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.83 VEGFA S100B NTRK3 MDM2 CDKN1B
2 lens fiber cell differentiation GO:0070306 9.4 NTRK3 NF2
3 positive regulation of positive chemotaxis GO:0050927 9.37 VEGFA NTRK3
4 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.33 MUC1 MDM2 CDKN1B
5 cellular response to antibiotic GO:0071236 9.32 MDM2 CDKN1B
6 vascular wound healing GO:0061042 9.26 VEGFA CD34
7 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
8 positive regulation of gene expression GO:0010628 9.1 VIM VEGFA NTRK3 MDM2 CD34 ACTC1

Molecular functions related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 VIM VEGFA SSX2 SSX1 SS18 SERPINA3
2 p53 binding GO:0002039 9.13 NTRK3 MUC1 MDM2
Sources

Sources for Spindle Cell Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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