MCID: SPN035
MIFTS: 51

Spindle Cell Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Sarcoma

MalaCards integrated aliases for Spindle Cell Sarcoma:

Name: Spindle Cell Sarcoma 12 6 15
Sarcoma 44 70
Sarcoma, Spindle Cell 70
Sarcoma Spindle Cell 54
Sarcoma - Category 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4235
MeSH 44 D012509
NCIt 50 C27005
SNOMED-CT 67 9801004
UMLS 70 C0205945 C1261473 C1299262

Summaries for Spindle Cell Sarcoma

Disease Ontology : 12 A sarcoma that results in cells that are spindle-shaped. They are usually resistant to radiation therapy.

MalaCards based summary : Spindle Cell Sarcoma, also known as sarcoma, is related to alveolar soft part sarcoma and endometrial stromal sarcoma. An important gene associated with Spindle Cell Sarcoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Cytoskeletal Signaling. The drugs Bleomycin and Efavirenz have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and uterus.

Wikipedia : 73 Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when... more...

Related Diseases for Spindle Cell Sarcoma

Diseases related to Spindle Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2183)
# Related Disease Score Top Affiliating Genes
1 alveolar soft part sarcoma 33.0 VIM DES ACTC1
2 endometrial stromal sarcoma 32.8 VIM S100B DES ACTC1
3 epithelioid sarcoma 32.7 VIM MUC1 KRT7 CD34
4 botryoid rhabdomyosarcoma 32.6 DES ACTC1
5 reticulum cell sarcoma 32.5 VIM MUC1 DES ACTC1
6 retroperitoneal sarcoma 32.5 SSX2 MDM2 CD34
7 undifferentiated embryonal sarcoma of the liver 32.4 SERPINA3 MDM2
8 vaginal endometrial stromal sarcoma 32.3 VIM CD34
9 kidney sarcoma 32.2 SSX2 SSX1
10 central epithelioid sarcoma 32.2 VIM KRT7 CD34
11 pancreas sarcoma 32.2 SERPINA3 MDM2
12 dendritic cell tumor 32.1 VIM S100B NCOA2 MUC1 ACTC1
13 embryonal sarcoma 32.1 VIM SERPINA3 S100B MDM2 DES
14 vulvar proximal-type epithelioid sarcoma 32.1 VIM KRT7 CD34
15 myxoid liposarcoma 32.0 SSX2 SSX1 MDM2
16 biphasic synovial sarcoma 32.0 VIM SSX2 SSX1 MUC1 DES
17 vagina sarcoma 32.0 VIM CD34
18 lung sarcoma 32.0 SSX2 SSX1 SERPINA3 CD34
19 epithelioid cell synovial sarcoma 31.9 SSX2 SSX1 KRT7 CD34
20 fallopian tube adenosarcoma 31.8 NCOA2 MEIS1
21 reticulosarcoma 31.8 SERPINA3 MUC1 CDKN1B
22 fallopian tube carcinosarcoma 31.8 NCOA2 MEIS1
23 bednar tumor 31.8 VIM S100B
24 giant cell glioblastoma 31.8 SERPINA3 MDM2 CD34
25 rhabdoid cancer 31.8 VIM SSX2 SERPINA3 NF2 MUC1 DES
26 desmoplastic small round cell tumor 31.7 VIM S100B MUC1 DES ACTC1
27 prostate angiosarcoma 31.7 VEGFA CD34
28 mesothelioma, malignant 31.7 VIM NF2 MUC1 KRT7
29 adenosarcoma 31.7 VIM SERPINA3 DES ACTC1
30 monophasic synovial sarcoma 31.7 VIM SSX2 SSX1 S100B MUC1 KRT7
31 chondrosarcoma, extraskeletal myxoid 31.6 SSX2 SSX1 CD34
32 breast leiomyosarcoma 31.6 KRT7 CD34
33 malignant mesenchymoma 31.5 SSX2 SERPINA3 MDM2 DES CD34
34 muscle cancer 31.5 SSX2 SSX1 SERPINA3 MDM2 DES CD34
35 plasmablastic lymphoma 31.5 MUC1 DES
36 chordoma 31.5 VIM VEGFA SERPINA3 S100B MUC1 KRT7
37 sarcoma 31.4 VIM VEGFA SSX2 SSX1 S100B NF2
38 soft tissue sarcoma 31.3 VEGFA MDM2
39 leukemia, acute myeloid 31.2 VEGFA SERPINA3 NCOA2 MEIS1 MDM2 CDKN1B
40 leiomyoma 31.2 VIM DES CD34 ACTC1
41 benign mesothelioma 31.2 VIM NF2 KRT7
42 rare tumor 31.0 NF2 DES ACTC1
43 wilms tumor 1 31.0 VIM VEGFA SERPINA3 MUC1 KRT7 DES
44 fibrosarcoma 30.9 VIM NTRK3 DES ACTC1
45 secretory meningioma 30.9 VIM SERPINA3 NF2 MUC1 KRT7
46 hemangiopericytoma, malignant 30.9 VIM SSX2 SSX1 SERPINA3 S100B MUC1
47 rhabdomyosarcoma 2 30.8 SSX2 SSX1 NCOA2 MDM2 DES
48 adenocarcinoma 30.8 VEGFA NTRK3 MUC1 MDM2 KRT7 CDKN1B
49 bacillary angiomatosis 30.8 VEGFA CD34
50 hemangioma 30.8 VIM VEGFA MUC1 KRT7 CD34 ACTC1

Graphical network of the top 20 diseases related to Spindle Cell Sarcoma:



Diseases related to Spindle Cell Sarcoma

Symptoms & Phenotypes for Spindle Cell Sarcoma

Drugs & Therapeutics for Spindle Cell Sarcoma

Drugs for Spindle Cell Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 506)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 4 11056-06-7 5360373
2
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
3
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
4
Lopinavir Approved Phase 4 192725-17-0 92727
5
Nevirapine Approved Phase 4 129618-40-2 4463
6
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
7
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
8
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
9
Sirolimus Approved, Investigational Phase 4 53123-88-9 6436030 5284616
10
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
11
tannic acid Approved Phase 4 1401-55-4
12
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
13
Tranexamic Acid Approved Phase 4 1197-18-8 5526
14
Heparin Approved, Investigational Phase 4 9005-49-6 772 9812414
15
Dalteparin Approved Phase 4 9005-49-6
16
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
17
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
18
Enoxaparin Approved Phase 4 9005-49-6 772
19
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
20 Reverse Transcriptase Inhibitors Phase 4
21 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
22 Antifungal Agents Phase 4
23 Coagulants Phase 4
24 Antifibrinolytic Agents Phase 4
25 Hemostatics Phase 4
26 Anticoagulants Phase 4
27 Fibrinolytic Agents Phase 4
28 Heparin, Low-Molecular-Weight Phase 4
29 calcium heparin Phase 4
30 Antipyretics Phase 4
31 Platelet Aggregation Inhibitors Phase 4
32
Zidovudine Approved Phase 3 30516-87-1 35370
33
Ritonavir Approved, Investigational Phase 2, Phase 3 155213-67-5 392622
34
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
35
Treosulfan Approved, Investigational Phase 3 299-75-2 9296
36
Abacavir Approved, Investigational Phase 2, Phase 3 136470-78-5 441300 65140
37
Panitumumab Approved, Investigational Phase 3 339177-26-3 50070211
38
Palbociclib Approved, Investigational Phase 3 571190-30-2 5005498 5330286 11431660
39
Olaparib Approved Phase 3 763113-22-0 23725625
40
Trametinib Approved Phase 3 871700-17-3 11707110
41
Ceritinib Approved Phase 3 1032900-25-6
42
Dabrafenib Approved, Investigational Phase 3 1195765-45-7 44462760 44516822
43
Lapatinib Approved, Investigational Phase 3 231277-92-2, 388082-78-8 208908 9941095
44
Sorafenib Approved, Investigational Phase 3 284461-73-0 216239 406563
45
Ifosfamide Approved Phase 3 3778-73-2 3690
46
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
47
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
48
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
49
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
50
Olaratumab Approved, Investigational Phase 3 1024603-93-7

Interventional clinical trials:

(show top 50) (show all 1414)
# Name Status NCT ID Phase Drugs
1 EpSSG (European Soft Tissue Sarcoma Study Group) Protocol for Non-Metastatic Rhabdomyosarcoma in Children Unknown status NCT00339118 Phase 4 doxorubicin, cytoxan
2 A Randomized Comparison of Protease Inhibitor-based Versus Non-nucleoside Reverse Transcriptase Inhibitor-based Antiretroviral Therapy for Initial Treatment of Individuals With AIDS-related Kaposi's Sarcoma in Sub-Saharan Africa Completed NCT00444379 Phase 4 Lopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir
3 A Prospective Randomized Trial Comparing the Response of HIV Kaposi's Sarcoma (KS) to HAART Versus the Combination of HAART and Chemotherapy (CXT) Completed NCT00380770 Phase 4 Generic HAART Triomune : d4T, 3TC, NVP;Generic HAART Triomune : d4T, 3TC, NVP and chemotherapy ABV
4 Pharmacologic Interaction Between Ifosfamide and Aprepitant in Treated Patients With Soft Tissue Sarcoma Completed NCT03514381 Phase 4 Patients starting a treatment with Doxorubicin and Ifosfamide
5 Prospective, Randomized Evaluation of Hyperbaric Oxygen Therapy on Wound Healing Following Management of Soft Tissue Sarcoma With Neo-Adjuvant Radiation and Surgical Resection Recruiting NCT03144206 Phase 4 Hyperbaric oxygen
6 Quality of Life in Patients With Non-adipocyte Soft Tissue Sarcoma Under Palliative Chemotherapy or Pazopanib - a Randomized, Controlled Trial Recruiting NCT03735758 Phase 4 pazopanib or guideline conform chemotherapy
7 Registry of Retroperitoneal, Abdominal, Pelvic and Truncal Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet® to Evaluate the Safety and Feasibility Over 5 Years Recruiting NCT04033081 Phase 4
8 Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule Recruiting NCT04223583 Phase 4 Anlotinib Hydrochloride
9 Tranexamic Acid in Radical Resection and Endoprosthetic Reconstruction: A Randomized Controlled Trial Recruiting NCT04347122 Phase 4 Tranexamic Acid (TXA)
10 Guided Discontinuation Versus Maintenance Treatment of Sirolimus in Pediatric Patients With Kaposiform Hemangioendothelioma: a Randomized Controlled Trial Recruiting NCT04448873 Phase 4 Sirolimus
11 Tacrolimus for the Treatment of Superficial Kaposiform Hemangioendothelioma and Tufted Angioma: a Single Arm Prospective Study Recruiting NCT04056962 Phase 4 Tacrolimus ointment
12 Safety and Efficacy of Low-dose Sirolimus to Kaposiform Hemangioendothelioma:A Prospective, Randomized Open Trial Recruiting NCT04077515 Phase 4 Sirolimus(0.8mg/m2);Sirolimus(0.7mg/m2)
13 Low Molecular Weight Heparin Versus Aspirin for Venous Thromboembolism Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
14 Phase III Study of The Role of Barrier Resection in Local Control in Treatment of Extremity Soft Tissue Sarcomas Unknown status NCT02120768 Phase 3
15 Risk-Based Treatment for Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) in Patients Under 30 Years of Age Unknown status NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
16 EUROPEAN INTERGROUP COOPERATIVE EWING'S SARCOMA STUDY [EICESS 92] Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
17 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Adriamycin, Bleomycin, and Vincristine (ABV) in the Treatment of Severe AIDS-Related Kaposi's Sarcoma Unknown status NCT00002318 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
18 A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS) Unknown status NCT01344018 Phase 3
19 A Registered Randomized, Double-Blind, Placebo-Controlled (2:1), Multi-Centered Clinical Trial of Anlotinib as a Treatment for Soft Tissue Sarcoma Unknown status NCT02449343 Phase 2, Phase 3 Anlotinib;Placebo
20 A Protocol For Nonmetastatic Rhabdomyosarcoma [RMS-2005] Unknown status NCT00379457 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate;vinorelbine tartrate
21 Phase III Study About the Effects of the Addition of Polychemotherapy to Adjuvant Radiotherapy in the Treatment of Non-Metastatic Uterine Sarcomas Unknown status NCT00162721 Phase 3 doxorubicin, ifosfamide, cisplatin
22 European Ewing Tumour Working Initiative of National Groups Ewing Tumour Studies 1999 (EURO-E.W.I.N.G.99) Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
23 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
24 Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) Versus VAC Alternating With Vincristine and Irinotecan (VI) for Patients With Intermediate-Risk Rhabdomyosarcoma (RMS) Unknown status NCT00354835 Phase 3 Irinotecan Hydrochloride;Cyclophosphamide;Vincristine Sulfate
25 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
26 A Multicenter, Randomized, Open-Label Phase 3 Study to Investigate the Efficacy and Safety of Aldoxorubicin Compared to Investigator's Choice in Subjects With Metastatic, Locally Advanced, or Unresectable Soft Tissue Sarcomas Who Either Relapsed or Were Refractory to Prior Non-Adjuvant Chemotherapy Completed NCT02049905 Phase 3 Aldoxorubicin;Investigator's Choice Treatment (Darcabazine, Pazopanib, Gemcitabine + Docetaxel, Doxorubicin, Ifosfamide)
27 Establishment of an Indication-based Identification and Psychosocial Treatment of Orthopedic Cancer Patients Suffering From Psychosocial Stress Completed NCT01631175 Phase 3
28 Ph III Random Trial of 120-Min Infusion Gemcitabine v. 90-Min Infusion Gemcitabine + Docetaxel in Unresectable Soft Tissue Sarcoma: A Multi-Disciplinary Trial of the North Amer. Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00142571 Phase 3 Gemcitabine;Docetaxel
29 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
30 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
31 Open Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma Completed NCT00002319 Phase 3 Doxorubicin hydrochloride (liposomal)
32 A Placebo-Controlled Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS-Associated Kaposi's Sarcoma Completed NCT00000994 Phase 3 Zidovudine
33 A Phase III Randomized Placebo Controlled and Double Blinded Study of IM862 for Patients With Muco-Cutaneous AIDS Associated Kaposi's Sarcoma Completed NCT00002445 Phase 3 IM862
34 Phase 3, Open Label, Multi-centre, Randomised Controlled International Study in Ewing Sarcoma Completed NCT00987636 Phase 3 Zoledronic acid;Busulfan;Treosulfan
35 Trial of Chemotherapy Intensification Through Compression in Ewing's Sarcoma and Related Tumors Completed NCT00006734 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
36 Use of Stealth Liposomal Doxorubicin HCl ( DOX-SL ) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma. Completed NCT00002147 Phase 3 Doxorubicin hydrochloride (liposomal)
37 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002105 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate
38 Phase III Study of Paclitaxel Versus Liposomal Doxorubicin for the Treatment of Advanced AIDS-Associated Kaposi's Sarcoma Completed NCT00003350 Phase 3 paclitaxel;pegylated liposomal doxorubicin hydrochloride
39 Double-Blind Randomized Evaluation of Clinical Benefits of DOXIL in Patients With AIDS-Related Kaposi's Sarcoma Treated With DOXIL or DaunoXome Completed NCT00002985 Phase 3 daunorubicin hydrochloride;pegylated liposomal doxorubicin hydrochloride
40 A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma. Completed NCT00002093 Phase 3 Daunorubicin (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
41 A Pilot Study Of the Effects of Highly Active Antiretroviral Therapy on Kaposi's Sarcoma in Zimbabwe Completed NCT00834457 Phase 2, Phase 3 abacavir/3TC/zidovudine;abacavir /3TC plus ritonavir boosted lopinavir
42 A Randomized Evaluation of Antiretroviral Therapy Alone or With Delayed Chemotherapy Versus Antiretroviral Therapy With Immediate Adjunctive Chemotherapy for Treatment of Limited Stage AIDS-KS in Resource-Limited Settings (REACT-KS) AMC 067 Completed NCT01352117 Phase 3 efavirenz/emtricitabine/tenofovir disoproxil fumarate;etoposide
43 Randomized Double-blind Placebo-controlled Trial of Primary Prophylaxis With Recombinant Human Thrombopoietin Administered to Patients With High Risk Sarcoma Receiving Intensive Chemotherapy Completed NCT00283582 Phase 3 rhTPO
44 Actinomycin D and Vincristine With or Without Radiation Therapy, for Newly Diagnosed Patients With Low-Risk Rhabdomyosarcoma or Undifferentiated Sarcoma: IRS-V Protocol Completed NCT00002995 Phase 3 cyclophosphamide;vincristine sulfate
45 A Randomized Phase 3, Multicenter, Open-Label Study Comparing TH-302 in Combination With Doxorubicin vs. Doxorubicin Alone in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma Completed NCT01440088 Phase 3 TH-302 in Combination with Doxorubicin;Doxorubicin
46 A Phase III Multicenter, International, Randomized, Double-blind, Placebo-controlled Study of Doxorubicin Plus Palifosfamide-tris vs. Doxorubicin Plus Placebo in Patients With Front-line Metastatic Soft Tissue Sarcoma. Completed NCT01168791 Phase 3 doxorubicin in combination with palifosfamide-tris;doxorubicin in combination with placebo
47 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
48 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
49 Phase III Randomized Study of Adjuvant Pelvic Radiotherapy Versus Observation Alone in Patients With Completely Resected, Stage I or II, High-Grade Uterine Sarcoma Completed NCT00002459 Phase 3
50 A Phase III Randomized Clinical Trial of Laparoscopic Pelvic and Para-Aortic Node Sampling With Vaginal Hysterectomy and BSO Versus Open Laparotomy With Pelvic and Para-Aortic Node Sampling and Abdominal Hysterectomy and BSO in Endometrial Adenocarcinoma and Uterine Sarcoma, Clinical Stage I, IIA, Grade I, II, III Completed NCT00002706 Phase 3

Search NIH Clinical Center for Spindle Cell Sarcoma

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Ifosfamide
Mitoxantrone
Mitoxantrone Hydrochloride
Thiotepa

Cochrane evidence based reviews: sarcoma

Genetic Tests for Spindle Cell Sarcoma

Anatomical Context for Spindle Cell Sarcoma

MalaCards organs/tissues related to Spindle Cell Sarcoma:

40
Myeloid, Bone, Uterus, Endothelial, Bone Marrow, Prostate, T Cells

Publications for Spindle Cell Sarcoma

Articles related to Spindle Cell Sarcoma:

(show top 50) (show all 30393)
# Title Authors PMID Year
1
Carcinosarcoma in the pouch of douglas. 61 54
19484471 2010
2
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. 54 61
17343592 2007
3
Primary intraabdominal synovial sarcoma: a case report. 54 61
15800696 2005
4
An ultrastructural, immunohistochemical, and cytogenetical study of a monophasic pulmonary synovial sarcoma: implications of the frequent ultrastructure of oligocilia and concentric membranous bodies with positive immunostaining for VS38c and MEF2. 54 61
12907368 2003
5
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors. 61 54
11570907 2001
6
Malignant mixed müllerian tumors of the ovary. 54 61
10820916 2000
7
Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3. 54 61
9563467 1998
8
Corticomedullary tumors of the adrenal glands. Report of two cases. Association of corticomedullary tumor with spindle cell sarcoma. 54 61
9122025 1996
9
Primary retroperitoneal synovial sarcoma. 54 61
7849384 1994
10
Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. 54 61
1718079 1991
11
Clear cell sarcoma of the kidney in Austrian children: Long-term survival after relapse. 61
33438324 2021
12
A rare case report of breast sarcoma. 61
33680274 2021
13
Indeterminate pulmonary nodules are not associated with worse overall survival in Ewing Sarcoma. 61
33717939 2021
14
Primary Ewing Sarcoma of Seminal Vesicle on PET/CT. 61
33630793 2021
15
The first pediatric case of sacral Ewing sarcoma treated with space-making particle therapy. 61
33314634 2021
16
Extraskeletal Ewing sarcoma of the buccal space. 61
33360836 2021
17
Extraskeletal Ewing sarcoma: Diagnosis, management and prognosis. 61
33747211 2021
18
Rare presentation of isolated bilateral testicular myeloid sarcoma: A case report. 61
33552919 2021
19
Extra-uterine endometrial stromal sarcoma of the left adnexa and distal ureter: A case report. 61
33553557 2021
20
Potential application of genomic profiling for the diagnosis and treatment of patients with sarcoma. 61
33747210 2021
21
Clinical management and outcomes of primary ovarian leiomyosarcoma - Experience from a sarcoma specialist unit. 61
33732852 2021
22
Electrochemotherapy in Kaposi sarcoma: A systematic review. 61
33680455 2021
23
Successful treatment of nodular human immunodeficiency virus-associated Kaposi sarcoma of the foot utilizing combination intralesional bleomycin and cryotherapy. 61
33732841 2021
24
Tazemetostat for advanced epithelioid sarcoma: current status and future perspectives. 61
33289402 2021
25
Histiocytic sarcoma following combination chemotherapy for primary mediastinal germ cell tumor: a diagnostic dilemma. 61
33786289 2021
26
Intestinal epithelioid sarcoma. 61
33051050 2021
27
Epithelioid Sarcoma of the Tongue: An Unusual Tumor Mimic for Squamous Cell Carcinoma. 61
32814436 2021
28
The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma. 61
33811537 2021
29
Postmarketing observational study of pazopanib in patients with metastatic soft tissue sarcoma in Japan. 61
33283234 2021
30
Reconstruction of upper limb soft-tissue defects after sarcoma resection with free flaps: A systematic review. 61
33277214 2021
31
Switch maintenance therapy with anlotinib after chemotherapy in unresectable or metastatic soft tissue sarcoma: a single-center retrospective study. 61
32974853 2021
32
Surgical management of paratesticular rhabdomyosarcoma: A consensus opinion from the Children's Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe. 61
33522706 2021
33
Long-term patient-reported outcome measures following limb salvage with complex reconstruction or amputation in the treatment of upper extremity sarcoma. 61
33650694 2021
34
EWSR1-PATZ1-rearranged sarcoma: a report of nine cases of spindle and round cell neoplasms with predilection for thoracoabdominal soft tissues and frequent expression of neural and skeletal muscle markers. 61
33012788 2021
35
Mediastinal undifferentiated pleomorphic sarcoma with pleural effusion cytopathologically misdiagnosed as epithelial malignant pleural mesothelioma: An autopsy case report. 61
33605078 2021
36
Metastatic Low-Grade Sarcoma with CARS-ALK Fusion Dramatically Responded to Multiple ALK Tyrosine Kinase Inhibitors: A Case Report with Comprehensive Genomic Analysis. 61
32997436 2021
37
[Successful treatment with paclitaxel of a visceral relapse of post-transplant Kaposi's sarcoma]. 61
33563572 2021
38
Primary synovial sarcoma of the mediastinum: a rare tumor diagnosed by endoscopic ultrasound-fine needle biopsy (EUS-FNB)-Cytomorphologic, immunohistochemical, and molecular analysis. 61
33792887 2021
39
Soft tissue sarcoma in adolescent and young adult patients: a retrospective study using a nationwide bone and soft tissue tumor registry in Japan. 61
33791777 2021
40
The value of re-staging chest CT at first local recurrence of extremity and trunk soft tissue sarcoma. 61
33037910 2021
41
Surgical treatment of primary pulmonary artery sarcoma. 61
32918676 2021
42
Primary capicua transcriptional repressor-rearranged sarcoma of the lung. 61
33338234 2021
43
Langerhans cell sarcoma involving skin and showing epidermotropism: A comprehensive review. 61
32644218 2021
44
Late metastasis in Ewing sarcoma. 61
33155385 2021
45
Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma. 61
33480647 2021
46
Mithramycin A Radiosensitizes EWS:Fli1+ Ewing Sarcoma Cells by Inhibiting Double Strand Break Repair. 61
33373655 2021
47
Irinotecan and temozolomide chemotherapy in paediatric and adult populations with relapsed Ewing Sarcoma. 61
32761317 2021
48
Secondary CIC-rearranged sarcoma responsive to chemotherapy regimens for Ewing sarcoma: A case report. 61
33680459 2021
49
Clinicopathologic and Molecular Cytogenetic Analysis of 8 Cases With Uterine Cervical Ewing Sarcoma: Case Series With Literature Review. 61
33538423 2021
50
Final analysis of the randomized trial on imatinib as an adjuvant in localized gastrointestinal stromal tumors (GIST) from the EORTC Soft Tissue and Bone Sarcoma Group (STBSG), the Australasian Gastro-Intestinal Trials Group (AGITG), UNICANCER, French Sarcoma Group (FSG), Italian Sarcoma Group (ISG), and Spanish Group for Research on Sarcomas (GEIS)☆. 61
33482247 2021

Variations for Spindle Cell Sarcoma

ClinVar genetic disease variations for Spindle Cell Sarcoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NF2 NM_000268.4(NF2):c.583_589del (p.His195fs) Deletion Pathogenic 585330 rs1569294187 GRCh37: 22:30051646-30051652
GRCh38: 22:29655657-29655663
2 MGA , NUTM1 der(15)t(5:15)(q23.2;q15.1) Translocation Pathogenic 585331 GRCh37:
GRCh38:
3 overlap with 62 genes GRCh37/hg19 15q14-15.1 chr15:34638237..42057083 complex variant Complex Pathogenic 585332 GRCh37: 15:34638237-42057083
GRCh38:

Expression for Spindle Cell Sarcoma

Search GEO for disease gene expression data for Spindle Cell Sarcoma.

Pathways for Spindle Cell Sarcoma

Pathways related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.64 SSX2 SSX1 MEIS1 MDM2 CDKN1B
2 11.59 VIM NF2 MUC1 KRT7 DES ACTC1
3 11.33 VIM VEGFA S100B
4 11.19 VIM DES ACTC1

GO Terms for Spindle Cell Sarcoma

Cellular components related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.53 VIM SSX2 SSX1 SERPINA3 S100B NUTM1

Biological processes related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of lipid metabolic process GO:0019216 9.61 SERPINA3 NCOA2 GPS2
2 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.43 MUC1 MDM2 CDKN1B
3 positive regulation of cell proliferation GO:0008284 9.43 VEGFA S100B NTRK3 MEIS1 MDM2 CDKN1B
4 positive regulation of positive chemotaxis GO:0050927 9.4 VEGFA NTRK3
5 cellular response to antibiotic GO:0071236 9.37 MDM2 CDKN1B
6 muscle filament sliding GO:0030049 9.33 VIM DES ACTC1
7 vascular wound healing GO:0061042 9.32 VEGFA CD34
8 positive regulation of gene expression GO:0010628 9.1 VIM VEGFA NTRK3 MDM2 CD34 ACTC1

Molecular functions related to Spindle Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 VIM VEGFA SSX2 SSX1 SERPINA3 S100B
2 p53 binding GO:0002039 8.8 NTRK3 MUC1 MDM2

Sources for Spindle Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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