MCID: SPN034
MIFTS: 19

Spindle Cell Synovial Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Synovial Sarcoma

MalaCards integrated aliases for Spindle Cell Synovial Sarcoma:

Name: Spindle Cell Synovial Sarcoma 12 15
Synovial Sarcoma with Spindle Cell Components 12
Synovial Sarcoma, Monophasic Fibrous 12
Synovial Sarcoma, Spindle Cell 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5487
NCIt 50 C4277
SNOMED-CT 67 37206003
UMLS 70 C0334505

Summaries for Spindle Cell Synovial Sarcoma

MalaCards based summary : Spindle Cell Synovial Sarcoma, also known as synovial sarcoma with spindle cell components, is related to sarcoma and spindle cell sarcoma. An important gene associated with Spindle Cell Synovial Sarcoma is SSX2 (SSX Family Member 2), and among its related pathways/superpathways is Transcriptional misregulation in cancer. Affiliated tissues include tongue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Spindle Cell Synovial Sarcoma

Diseases related to Spindle Cell Synovial Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 sarcoma 30.4 SSX2 SSX1 SS18
2 spindle cell sarcoma 28.9 TLE1 SSX2 SSX1 SS18 CD34 CCNB3
3 sarcoma, synovial 28.6 TLE1 TBC1D25 SSX2 SSX1 SS18 CD34
4 meninges sarcoma 10.2 SSX2 SS18
5 mediastinal mesenchymal tumor 10.1 TLE1 SS18
6 malignant glandular tumor of peripheral nerve sheath 10.1 TLE1 SSX2
7 congenital mesoblastic nephroma 10.1 SSX2 CCNB3
8 tibial adamantinoma 10.1 TLE1 SSX1
9 rare soft tissue tumor 10.1
10 extraosseous chondrosarcoma 10.1 SSX2 SS18
11 adamantinoma of long bones 10.1 TLE1 SSX1
12 kidney fibrosarcoma 10.1 SSX2 SSX1
13 pleomorphic liposarcoma 10.1 SSX2 SS18
14 cellular myxoid liposarcoma 10.0 SSX2 SSX1 SS18
15 myxoid liposarcoma 10.0 SSX2 SSX1 SS18
16 rhabdoid cancer 9.9 SSX2 SS18
17 kidney cortex disease 9.9 SSX2 SS18 CCNB3
18 liver fibroma 9.9 SSX2 CD34
19 kidney clear cell sarcoma 9.9 TLE1 CCNB3
20 adult fibrosarcoma 9.9 SSX1 CD34
21 retroperitoneal sarcoma 9.9 SSX2 CD34
22 cellular congenital mesoblastic nephroma 9.9 TLE1 SSX2 CCNB3
23 malignant mesenchymoma 9.9 SSX2 CD34
24 spindle cell liposarcoma 9.9 TLE1 CD34
25 extraosseous osteosarcoma 9.8 SSX1 CD34
26 esophagus sarcoma 9.8 SSX2 CD34
27 subungual glomus tumor 9.8 TLE1 CD34
28 glomus tumor 9.8 TLE1 CD34
29 pseudosarcomatous fibromatosis 9.8 SS18 CD34
30 kidney hemangiopericytoma 9.8 SSX2 SS18 CD34
31 synovium neoplasm 9.7 TLE1 SSX2 SSX1 SS18
32 biphasic synovial sarcoma 9.7 TLE1 SSX2 SSX1 SS18
33 pediatric fibrosarcoma 9.7 CD34 CCNB3
34 spermatic cord cancer 9.7 SSX2 SSX1 CD34
35 cellular schwannoma 9.7 SSX1 SS18 CD34
36 dedifferentiated liposarcoma 9.7 SSX2 SS18 CD34
37 heart sarcoma 9.7 SSX2 SSX1 CD34
38 lung sarcoma 9.7 SSX2 SSX1 CD34
39 rhabdomyosarcoma 2 9.7 SSX2 SSX1 SS18 CCNB3
40 mesenchymal cell neoplasm 9.6 SSX2 CD34 CCNB3
41 ewing sarcoma 9.6 TLE1 SSX1 SS18 CCNB3
42 epithelioid sarcoma 9.6 FXYD5 CD34
43 epithelioid cell synovial sarcoma 9.5 SSX2 SSX1 SS18 CD34
44 well-differentiated liposarcoma 9.5 SSX2 SSX1 SS18 CD34
45 skeletal muscle cancer 9.5 SSX2 SSX1 SS18 CD34
46 muscle cancer 9.5 SSX2 SSX1 SS18 CD34
47 epithelioid malignant peripheral nerve sheath tumor 9.5 TLE1 SSX2 SS18 CD34
48 connective tissue cancer 9.5 SSX2 SSX1 SS18 CD34
49 myxofibrosarcoma 9.5 TLE1 SSX2 SS18 CD34
50 dermatofibrosarcoma protuberans 9.5 TLE1 CD34

Graphical network of the top 20 diseases related to Spindle Cell Synovial Sarcoma:



Diseases related to Spindle Cell Synovial Sarcoma

Symptoms & Phenotypes for Spindle Cell Synovial Sarcoma

GenomeRNAi Phenotypes related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 9.17 TLE1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.17 TLE1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-183 9.17 TLE1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.17 SSX1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.17 SSX1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.17 SSX2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.17 SSX2

Drugs & Therapeutics for Spindle Cell Synovial Sarcoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Synovial Sarcoma

Genetic Tests for Spindle Cell Synovial Sarcoma

Anatomical Context for Spindle Cell Synovial Sarcoma

MalaCards organs/tissues related to Spindle Cell Synovial Sarcoma:

40
Tongue

Publications for Spindle Cell Synovial Sarcoma

Articles related to Spindle Cell Synovial Sarcoma:

(show all 18)
# Title Authors PMID Year
1
Monophasic spindle cell myxoid synovial sarcoma of the hand: promising results with marginal resection. 61
33509874 2021
2
Primary Subcutaneous Spindle Cell Synovial Sarcoma: First Reported Case. 61
31343425 2020
3
Nasal spindle cell sarcoma: A case report. 61
32698278 2020
4
Monophasic Synovial Sarcoma of Tongue: A Rarest of Rare Case Scenario. 61
31742025 2019
5
Primary pulmonary synovial sarcoma with calcification: A case report. 61
31426131 2019
6
Expression of TLE1 in Malignant Melanoma With Spindle Cell Morphology: A Potential Diagnostic Pitfall. 61
30301396 2019
7
Evaluation of pan-TRK immunohistochemistry in infantile fibrosarcoma, lipofibromatosis-like neural tumour and histological mimics. 61
29863809 2018
8
Expression of PAX3 Distinguishes Biphenotypic Sinonasal Sarcoma From Histologic Mimics. 61
29863547 2018
9
[Interventional Bronchoscopy for the Treatment of Pulmonary Sarcoma]. 61
27666549 2016
10
Epidemiology and survivorship of soft tissue sarcomas in adults: a national cancer database report. 61
25044961 2014
11
Primary mediastinal synovial sarcoma: a case report and review of the literature. 61
19918499 2009
12
A novel variant of SYT-SSX1 fusion gene in a case of spindle cell synovial sarcoma. 61
17721327 2007
13
Primary pulmonary synovial sarcoma confirmed by molecular detection of SYT-SSX1 fusion gene transcripts: a case report and review of the literature. 61
15879502 2005
14
Radiation-associated synovial sarcoma: clinicopathologic and molecular analysis of two cases. 61
12218218 2002
15
[Malignant neoplasms of the peripheral nerve sheaths with cellular immunophenotype of perineural cells (perineural sarcoma?)]. 61
8579488 1995
16
Monophasic spindle cell synovial sarcoma of the head and neck: report of two cases an review of the literature. 61
8308633 1994
17
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. 61
3103455 1987
18
[Electron-microscopic study of monophasic spindle-cell synovial sarcomas]. 61
3006645 1985

Variations for Spindle Cell Synovial Sarcoma

Expression for Spindle Cell Synovial Sarcoma

Search GEO for disease gene expression data for Spindle Cell Synovial Sarcoma.

Pathways for Spindle Cell Synovial Sarcoma

Pathways related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.08 SSX2 SSX1 SS18

GO Terms for Spindle Cell Synovial Sarcoma

Sources for Spindle Cell Synovial Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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