MCID: SPN034
MIFTS: 29

Spindle Cell Synovial Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Synovial Sarcoma

MalaCards integrated aliases for Spindle Cell Synovial Sarcoma:

Name: Spindle Cell Synovial Sarcoma 12 15
Synovial Sarcoma with Spindle Cell Components 12
Synovial Sarcoma, Monophasic Fibrous 12
Synovial Sarcoma, Spindle Cell 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5487
NCIt 50 C4277
SNOMED-CT 68 37206003
UMLS 73 C0334505

Summaries for Spindle Cell Synovial Sarcoma

MalaCards based summary : Spindle Cell Synovial Sarcoma, also known as synovial sarcoma with spindle cell components, is related to sarcoma and sarcoma, synovial. An important gene associated with Spindle Cell Synovial Sarcoma is SSX1 (SSX Family Member 1), and among its related pathways/superpathways are Gastric cancer and Neural Crest Differentiation. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Spindle Cell Synovial Sarcoma

Diseases related to Spindle Cell Synovial Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 sarcoma 29.9 KIT SS18 SSX1 SSX2 SSX2B
2 sarcoma, synovial 27.8 KIT KRT7 MET SS18 SSX1 SSX2
3 proliferative fasciitis 10.9 MB SMARCB1
4 sensory organ benign neoplasm 10.8 ISL1 KRT7
5 deafness, autosomal recessive 39 10.7 HGF MET
6 middle ear adenoma 10.7 ISL1 KRT7
7 epithelioid cell synovial sarcoma 10.7 SSX1 SSX2B
8 kidney rhabdoid cancer 10.7 MB SMARCB1
9 deafness, autosomal recessive 97 10.7 HGF MET
10 extraskeletal mesenchymal chondrosarcoma 10.7 SSX1 SSX2B
11 renal pelvis adenocarcinoma 10.6 KRT7 SLC2A1
12 tibial adamantinoma 10.6 CD34 SSX1
13 endometrial squamous cell carcinoma 10.6 HGF MET
14 large cell medulloblastoma 10.6 HGF MET
15 jejunal cancer 10.5 KIT KRT7
16 central pontine myelinolysis 10.5 MAG MBP
17 meninges sarcoma 10.5 CD34 MB
18 epithelioid sarcoma 10.5 KRT7 MB SMARCB1
19 cribriform carcinoma 10.5 KIT KRT7
20 malignant mixed mullerian tumor 10.5 KIT KRT7
21 diffuse meningeal melanocytosis 10.4 CD34 HGF
22 monophasic synovial sarcoma 10.4 KRT7 SSX1
23 uterine sarcoma 10.4 KIT MB SMARCB1
24 gastric tubular adenocarcinoma 10.4 KRT7 MBP SIL1
25 vulvar dystrophy 10.4 CD34 MBP
26 gallbladder leiomyoma 10.4 CD34 KIT
27 lung leiomyosarcoma 10.4 CD34 KIT
28 sclerosing liposarcoma 10.4 CD34 MB
29 chordoma 10.4 KRT7 MET SMARCB1
30 adenoid basal cell carcinoma 10.4 KIT KRT7
31 liver leiomyoma 10.4 CD34 KIT
32 deep leiomyoma 10.4 CD34 KIT
33 extracutaneous mastocytoma 10.3 CD34 KIT
34 extraosseous osteosarcoma 10.3 CD34 KRT7
35 small intestine leiomyosarcoma 10.3 CD34 KIT
36 small intestinal sarcoma 10.3 CD34 KIT
37 intratubular embryonal carcinoma 10.3 KIT KRT7
38 gallbladder sarcoma 10.3 CD34 KIT
39 mixed cell type cancer 10.3 KIT KRT7 MB
40 malignant leydig cell tumor 10.3 KIT KRT7
41 prostate leiomyosarcoma 10.3 CD34 KIT
42 diffuse cutaneous mastocytosis 10.3 CD34 KIT
43 nephrogenic adenofibroma 10.2 CD34 KRT7 SS18
44 eccrine adenocarcinoma 10.2 CD34 KRT7
45 gastric leiomyosarcoma 10.2 CD34 KIT
46 cardiovascular organ benign neoplasm 10.2 CD34 MB SLC2A1
47 benign perivascular tumor 10.2 CD34 MB SLC2A1
48 glomangioma 10.2 CD34 MB SLC2A1
49 vulvar sarcoma 10.2 CD34 KRT7 SMARCB1
50 malignant mesenchymoma 10.2 KIT MB SSX2B

Graphical network of the top 20 diseases related to Spindle Cell Synovial Sarcoma:



Diseases related to Spindle Cell Synovial Sarcoma

Symptoms & Phenotypes for Spindle Cell Synovial Sarcoma

GenomeRNAi Phenotypes related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.36 SSX2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.36 TLE1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.36 SSX2B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.36 SSX2 SSX2B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.36 SSX1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.36 TLE1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.36 SSX1 SSX2 SSX2B TLE1

MGI Mouse Phenotypes related to Spindle Cell Synovial Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.93 SMARCB1 CD34 CDH2 HGF ISL1 KIT
2 embryo MP:0005380 9.61 SMARCB1 SS18 CDH2 HGF ISL1 KIT
3 homeostasis/metabolism MP:0005376 9.4 SLC2A1 CD34 SMARCB1 SS18 CDH2 ISL1

Drugs & Therapeutics for Spindle Cell Synovial Sarcoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Synovial Sarcoma

Genetic Tests for Spindle Cell Synovial Sarcoma

Anatomical Context for Spindle Cell Synovial Sarcoma

Publications for Spindle Cell Synovial Sarcoma

Articles related to Spindle Cell Synovial Sarcoma:

# Title Authors Year
1
A novel variant of SYT-SSX1 fusion gene in a case of spindle cell synovial sarcoma. ( 17721327 )
2007
2
Monophasic spindle cell synovial sarcoma of the head and neck: report of two cases an review of the literature. ( 8308633 )
1994
3
[Electron-microscopic study of monophasic spindle-cell synovial sarcomas]. ( 3006645 )
1985

Variations for Spindle Cell Synovial Sarcoma

Expression for Spindle Cell Synovial Sarcoma

Search GEO for disease gene expression data for Spindle Cell Synovial Sarcoma.

Pathways for Spindle Cell Synovial Sarcoma

Pathways related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 CDH17 HGF KIT MET SMARCB1
2 11.55 CDH2 ISL1 MBP
3 11.29 MET SS18 SSX1 SSX2 SSX2B
4 11.14 KIT MET SLC2A1
5 10.8 CDH2 HGF MET
6 10.63 HGF MET
7 10.16 MAG MBP

GO Terms for Spindle Cell Synovial Sarcoma

Cellular components related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 CD34 CDH17 CDH2 KIT MET
2 npBAF complex GO:0071564 8.96 SMARCB1 SS18
3 compact myelin GO:0043218 8.62 MAG MBP

Biological processes related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.67 HGF KIT MBP MET
2 phosphatidylinositol phosphorylation GO:0046854 9.61 HGF KIT MET
3 cell morphogenesis GO:0000902 9.58 CDH2 HGF SS18
4 negative regulation of nucleic acid-templated transcription GO:1903507 9.33 SSX1 SSX2 SSX2B
5 positive regulation of myelination GO:0031643 9.32 HGF MAG
6 hepatocyte growth factor receptor signaling pathway GO:0048012 9.26 HGF MET
7 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 8.96 HGF MET
8 positive regulation of granulocyte colony-stimulating factor production GO:0071657 8.62 CD34 ISL1

Molecular functions related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.13 HGF KIT MET
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 HGF KIT MET

Sources for Spindle Cell Synovial Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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