MCID: SPN034
MIFTS: 31

Spindle Cell Synovial Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Synovial Sarcoma

MalaCards integrated aliases for Spindle Cell Synovial Sarcoma:

Name: Spindle Cell Synovial Sarcoma 12 15
Synovial Sarcoma with Spindle Cell Components 12
Synovial Sarcoma, Monophasic Fibrous 12
Synovial Sarcoma, Spindle Cell 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5487
NCIt 50 C4277
SNOMED-CT 68 37206003
UMLS 73 C0334505

Summaries for Spindle Cell Synovial Sarcoma

MalaCards based summary : Spindle Cell Synovial Sarcoma, also known as synovial sarcoma with spindle cell components, is related to sarcoma, synovial and proliferative fasciitis. An important gene associated with Spindle Cell Synovial Sarcoma is SSX1 (SSX Family Member 1), and among its related pathways/superpathways are Neural Crest Differentiation and Transcriptional misregulation in cancer. Affiliated tissues include lung, skin and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Spindle Cell Synovial Sarcoma

Diseases related to Spindle Cell Synovial Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 sarcoma, synovial 29.3 CALB2 KRT7 MET SS18 SSX1 SSX2
2 proliferative fasciitis 10.2 MB SMARCB1
3 kidney rhabdoid cancer 10.2 MB SMARCB1
4 epithelioid cell synovial sarcoma 10.2 SSX1 SSX2B
5 middle ear adenoma 10.2 ISL1 KRT7
6 extraskeletal mesenchymal chondrosarcoma 10.2 SSX1 SSX2B
7 deafness, autosomal recessive 39 10.2 HGF MET
8 ceruminoma 10.2 KRT7 SLC2A1
9 deafness, autosomal recessive 97 10.2 HGF MET
10 renal pelvis adenocarcinoma 10.2 KRT7 SLC2A1
11 sarcoma 10.2
12 endometrial squamous cell carcinoma 10.2 HGF MET
13 large cell medulloblastoma 10.2 HGF MET
14 central pontine myelinolysis 10.2 MAG MBP
15 monophasic synovial sarcoma 10.2 KRT7 SSX1
16 salivary gland carcinoma 10.1 HGF ISL1 MET
17 epithelioid sarcoma 10.1 KRT7 MB SMARCB1
18 tibial adamantinoma 10.1 CD34 SSX1
19 hypotrichosis, congenital, with juvenile macular dystrophy 10.1 CDH17 CDH2
20 gastric tubular adenocarcinoma 10.1 KRT7 MBP SIL1
21 chordoma 10.1 KRT7 MET SMARCB1
22 meninges sarcoma 10.1 CD34 MB
23 epithelial predominant wilms' tumor 10.1 CDH17 KRT7
24 doxorubicin induced cardiomyopathy 10.1 HGF MET
25 sclerosing liposarcoma 10.1 CD34 MB
26 vulvar dystrophy 10.1 CD34 MBP
27 deep angioma 10.0 CD34 SLC2A1
28 large cell carcinoma with rhabdoid phenotype 10.0 CALB2 SMARCB1
29 cardiovascular organ benign neoplasm 10.0 CD34 MB SLC2A1
30 benign perivascular tumor 10.0 CD34 MB SLC2A1
31 cystitis cystica 10.0 CDH17 KRT7 SLC2A1
32 nephrogenic adenofibroma 10.0 CD34 KRT7 SS18
33 renal cell carcinoma, papillary, 1 10.0 KRT7 MET OSCAR
34 vulvar sarcoma 10.0 CD34 KRT7 SMARCB1
35 kidney hemangiopericytoma 10.0 CD34 SS18 SSX2B
36 mixed liposarcoma 10.0 CD34 MB
37 intraneural perineurioma 10.0 CD34 KRT7 SLC2A1
38 eccrine adenocarcinoma 10.0 CD34 KRT7
39 conventional angiosarcoma 10.0 CD34 OSCAR
40 bile duct cystadenocarcinoma 10.0 CALB2 KRT7
41 adult fibrosarcoma 10.0 CD34 MB
42 malignant leydig cell tumor 10.0 CALB2 KRT7
43 pericardium cancer 9.9 CALB2 KRT7 MB
44 clear cell adenofibroma 9.9 CALB2 KRT7 SLC2A1
45 intramuscular hemangioma 9.9 CD34 SLC2A1
46 pericardial mesothelioma 9.9 CALB2 KRT7 MB
47 synovium cancer 9.9 SMARCB1 SS18 SSX1 SSX2B TLE1
48 malignant biphasic mesothelioma 9.9 CALB2 KRT7 OSCAR
49 peritoneal benign neoplasm 9.9 CALB2 CD34
50 liposarcoma 9.8 CALB2 CD34 MB

Graphical network of the top 20 diseases related to Spindle Cell Synovial Sarcoma:



Diseases related to Spindle Cell Synovial Sarcoma

Symptoms & Phenotypes for Spindle Cell Synovial Sarcoma

GenomeRNAi Phenotypes related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.36 SSX2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.36 TLE1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.36 SSX2B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.36 SSX2 SSX2B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.36 SSX1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.36 TLE1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.36 SSX1 SSX2 SSX2B TLE1

MGI Mouse Phenotypes related to Spindle Cell Synovial Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.9 CD34 CDH2 HGF ISL1 KRT7 MB
2 embryo MP:0005380 9.56 CDH2 HGF ISL1 MB MET SLC2A1
3 nervous system MP:0003631 9.32 CALB2 CDH2 ISL1 MAG MBP MET

Drugs & Therapeutics for Spindle Cell Synovial Sarcoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Synovial Sarcoma

Genetic Tests for Spindle Cell Synovial Sarcoma

Anatomical Context for Spindle Cell Synovial Sarcoma

MalaCards organs/tissues related to Spindle Cell Synovial Sarcoma:

41
Lung, Skin, Kidney, Cervix, Thyroid, Thymus, Salivary Gland

Publications for Spindle Cell Synovial Sarcoma

Articles related to Spindle Cell Synovial Sarcoma:

# Title Authors Year
1
A novel variant of SYT-SSX1 fusion gene in a case of spindle cell synovial sarcoma. ( 17721327 )
2007
2
Monophasic spindle cell synovial sarcoma of the head and neck: report of two cases an review of the literature. ( 8308633 )
1994

Variations for Spindle Cell Synovial Sarcoma

Expression for Spindle Cell Synovial Sarcoma

Search GEO for disease gene expression data for Spindle Cell Synovial Sarcoma.

Pathways for Spindle Cell Synovial Sarcoma

Pathways related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 CDH2 ISL1 MBP
2 11.29 MET SS18 SSX1 SSX2 SSX2B
3 10.8 CDH2 HGF MET
4 10.55 HGF MET
5 10.06 MAG MBP

GO Terms for Spindle Cell Synovial Sarcoma

Cellular components related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.43 CD34 CDH17 CDH2 MBP MET OSCAR
2 SWI/SNF complex GO:0016514 9.26 SMARCB1 SS18
3 npBAF complex GO:0071564 9.16 SMARCB1 SS18
4 compact myelin GO:0043218 8.62 MAG MBP

Biological processes related to Spindle Cell Synovial Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon regeneration GO:0031103 9.32 ISL1 MAG
2 positive regulation of myelination GO:0031643 9.26 HGF MAG
3 hepatocyte growth factor receptor signaling pathway GO:0048012 9.16 HGF MET
4 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 8.96 HGF MET
5 positive regulation of granulocyte colony-stimulating factor production GO:0071657 8.62 CD34 ISL1

Sources for Spindle Cell Synovial Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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