MCID: SPN048
MIFTS: 28

Spindle Cell Thymoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Spindle Cell Thymoma

MalaCards integrated aliases for Spindle Cell Thymoma:

Name: Spindle Cell Thymoma 12 15
Thymoma, Medullary 12
Medullary Thymoma 12
Thymoma, Type a 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3279
NCIt 50 C6454
SNOMED-CT 67 128707003
UMLS 70 C1266091

Summaries for Spindle Cell Thymoma

MalaCards based summary : Spindle Cell Thymoma, also known as thymoma, medullary, is related to carcinosarcoma and malignant type a thymoma. An important gene associated with Spindle Cell Thymoma is DES (Desmin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs nivolumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include thymus, bone marrow and bone.

Related Diseases for Spindle Cell Thymoma

Diseases related to Spindle Cell Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 carcinosarcoma 29.9 MUC1 DES CALB2
2 malignant type a thymoma 11.2
3 thymoma, familial 10.5
4 thymoma 10.5
5 cutaneous leiomyosarcoma 10.2 MUC1 DES
6 parachordoma 10.2 MUC1 DES
7 fibroma 10.2 DES CALB2
8 syringocystadenoma papilliferum 10.2 MUC1 DES
9 plasmablastic lymphoma 10.2 MUC1 DES
10 reticulum cell sarcoma 10.2 MUC1 DES
11 ovarian fibrothecoma 10.2 DES CALB2
12 biphasic synovial sarcoma 10.2 MUC1 DES
13 adenofibroma 10.2 MUC1 CALB2
14 ischemic fasciitis 10.2 MUC1 DES
15 peritoneal mesothelioma 10.2 MUC1 CALB2
16 spindle cell rhabdomyosarcoma 10.2 MUC1 DES
17 proximal spinal muscular atrophy 10.2 MUC1 DES
18 syringoma 10.2 MUC1 DES
19 pleomorphic liposarcoma 10.2 MUC1 DES
20 perivascular epithelioid cell tumor 10.2 MUC1 DES
21 lung sarcomatoid carcinoma 10.2 MUC1 CALB2
22 pancreatic mucinous cystadenoma 10.2 MUC1 CALB2
23 nephroma 10.2 MUC1 DES
24 cystadenoma 10.2 MUC1 CALB2
25 pericardial mesothelioma 10.2 MUC1 CALB2
26 ovarian serous cystadenofibroma 10.2 MUC1 CALB2
27 endosalpingiosis 10.2 MUC1 CALB2
28 benign giant cell tumor 10.2 MUC1 DES
29 lipid-rich breast carcinoma 10.2 MUC1 KRT5
30 esophageal neuroendocrine tumor 10.2 MUC1 KRT5
31 monophasic synovial sarcoma 10.1 MUC1 CALB2
32 apocrine adenocarcinoma 10.1 MUC1 KRT5
33 bile duct mucoepidermoid carcinoma 10.1 MUC1 KRT5
34 cavernous hemangioma 10.1 MUC1 DES
35 spindle cell sarcoma 10.1 MUC1 DES
36 solid adenocarcinoma with mucin production 10.1 MUC1 KRT5
37 polycystic liver disease 1 with or without kidney cysts 10.1 MUC1 CALB2
38 papillary thymic adenocarcinoma 10.1 CD5 CALB2
39 myxofibrosarcoma 10.1 MUC1 DES
40 primitive neuroectodermal tumor of the cervix uteri 10.1 ENO2 DES
41 sex cord-gonadal stromal tumor 10.1 MUC1 CALB2
42 liver fibroma 10.1 KRT5 CALB2
43 lymphohistiocytoid mesothelioma 10.1 CD5 CALB2
44 testicular fibroma 10.1 KRT5 CALB2
45 rhabdoid cancer 10.1 MUC1 DES
46 pericardium cancer 10.1 KRT5 CALB2
47 malignant biphasic mesothelioma 10.1 KRT5 CALB2
48 congenital epulis 10.1 ENO2 DES
49 nephrogenic adenoma of the urethra 10.1 KRT5 CALB2
50 epulis 10.1 ENO2 DES

Graphical network of the top 20 diseases related to Spindle Cell Thymoma:



Diseases related to Spindle Cell Thymoma

Symptoms & Phenotypes for Spindle Cell Thymoma

Drugs & Therapeutics for Spindle Cell Thymoma

Drugs for Spindle Cell Thymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-arm, Multicentre, Phase II Study of Immunotherapy in Patients With Type B3 Thymoma and Thymic Carcinoma Previously Treated With Chemotherapy Recruiting NCT03134118 Phase 2 Nivolumab

Search NIH Clinical Center for Spindle Cell Thymoma

Genetic Tests for Spindle Cell Thymoma

Anatomical Context for Spindle Cell Thymoma

MalaCards organs/tissues related to Spindle Cell Thymoma:

40
Thymus, Bone Marrow, Bone, Lung, Thyroid, Neutrophil

Publications for Spindle Cell Thymoma

Articles related to Spindle Cell Thymoma:

(show top 50) (show all 80)
# Title Authors PMID Year
1
Management of thymomatous myasthenia gravis - Case report of a rare Covid19 infection sequelae. 61
33744800 2021
2
Ectopic thymoma in the middle mediastinum: A case report and literature review. 61
33763676 2021
3
RADIORYTHMIC: Phase III, Opened, Randomized Study of Postoperative Radiotherapy Versus Surveillance in Stage IIb/III of Masaoka Koga Thymoma after Complete Surgical Resection. 61
33736940 2021
4
Primary pulmonary meningiomas: report of two cases and review of the literature. 61
33045659 2020
5
A mutation analysis of the EGFR pathway genes, RAS, EGFR, PIK3CA, AKT1 and BRAF, and TP53 gene in thymic carcinoma and thymoma type A/B3. 61
31179560 2019
6
Influence of Smoking and Histologic Subtype on Developing Extrathymic Malignancy in Thymoma Patients. 61
30576633 2019
7
Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Atypical Thymoma With Rhabdomyomatous Differentiation. 61
30300145 2019
8
Thymoma and thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic analysis of 18 cases. 61
29945642 2018
9
Histogram analysis of apparent diffusion coefficient maps for assessing thymic epithelial tumours: correlation with world health organization classification and clinical staging. 61
29260882 2018
10
Good's Syndrome-Association of the Late Onset Combined Immunodeficiency with Thymoma: Review of Literature and Case Report. 61
29512373 2018
11
Surgical approach in thymectomy: Our experience and review of the literature. 61
28787670 2017
12
Concurrent spindle-cell thymoma and thymic cysts in a Barbary sheep (Ammotragus lervia): case report and review of the literature. 61
27698165 2016
13
Spindle cell thymomas with neuroendocrine morphology: a clinicopathological and immunohistochemical study of 18 cases. 61
24702597 2014
14
Diffusion-weighted MR imaging vs. multi-detector row CT: Direct comparison of capability for assessment of management needs for anterior mediastinal solitary tumors. 61
24636535 2014
15
Microscopic thymoma and parathyroid adenoma: rare combination of two distinct pathologies. 61
25002944 2014
16
The histomorphologic spectrum of spindle cell thymoma. 61
23260329 2014
17
Extrathoracic recurrence of type A thymoma. 61
24859411 2014
18
Desmoplastic spindle cell thymomas: a clinicopathologic and immunohistochemical study of 14 cases. 61
23084585 2013
19
Pulmonary metastasis from encapsulated cervical ectopic type a thymoma. 61
23176955 2012
20
Type A thymoma with generalised myasthenia gravis. 61
22128624 2011
21
Malignant invasive thymoma in the posterior mediastinum. 61
19324171 2009
22
My, what asthenia you have. 61
18929761 2008
23
Solitary fibrous tumor of the anterior mediastinum: a rare extrapleural neoplasm. 61
18038888 2007
24
Primary pericardial synovial sarcoma confirmed by molecular genetic studies: a case report. 61
17609629 2007
25
Spindle cell neuroendocrine carcinoma of the lung: report of a case with fine needle aspiration cytology and differential diagnostic considerations. 61
17425210 2007
26
High-dose methylprednisolone with chemotherapy for invasive thymoma: a case report. 61
17094379 2006
27
Malignant melanoma of mediastinum misdiagnosed as a spindle cell thymoma in a fine needle aspirate: a case report. 61
16124173 2005
28
[Case #2: thoracic pathology: thymoma type A or medullary thymoma]. 61
16149200 2005
29
Fine-needle aspiration biopsy of ectopic cervical spindle-cell thymoma: a case report. 61
15880711 2005
30
A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor. 61
15467709 2005
31
Primary intrapulmonary spindle cell thymoma with marked granulomatous reaction: report of a case with review of literature. 61
14615837 2003
32
Images in clinical medicine. Spindle-cell thymoma. 61
14534337 2003
33
Recurrent pneumonia post-thymectomy as a manifestation of Good syndrome. 61
12554014 2003
34
A novel animal model of thymic tumour: development of epithelial thymoma in transgenic rats carrying human T lymphocyte virus type I pX gene. 61
12641821 2002
35
[Recurrence of thymoma accompanied with hypogammaglobulinemia 20 years after surgery: a case report]. 61
11974900 2002
36
Pigmented spindle cell carcinoid tumour of the thymus with ectopic adrenocorticotropic hormone secretion: report of a rare variant and differential diagnosis of mediastinal spindle cell neoplasms. 61
11952860 2002
37
Pericardial rhabdomyomatous spindle cell thymoma with mucinous cystic degeneration. 61
11422489 2001
38
Spindle cell and mixed spindle/lymphocytic thymomas: an integrated clinicopathologic and immunohistochemical study of 81 cases. 61
11145245 2001
39
Histologic types of thymoma associated with pure red cell aplasia: a study of five cases including a composite tumor of organoid thymoma associated with an unusual lipofibroadenoma. 61
11469342 2001
40
Myasthenic crisis after resection of an isolated metastatic thymoma of the cervical spine. 61
19078542 1999
41
Micronodular thymoma with lymphoid B-cell hyperplasia: clinicopathologic and immunohistochemical study of eighteen cases of a distinctive morphologic variant of thymic epithelial neoplasm. 61
10435566 1999
42
Spindle cell thymic carcinoma: clinicopathologic and immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm. 61
10366152 1999
43
Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile. 61
9850173 1998
44
Thymoma-associated pancytopenia: effectiveness of cyclosporine A. 61
9829850 1998
45
Papillary carcinoma of the thymus: report of four cases of a new microscopic type of thymic carcinoma. 61
9669349 1998
46
Thymoma-associated cutaneous graft-versus-host-like reaction. 61
9604457 1997
47
Spindle-cell lesions of the mediastinum: diagnosis by fine-needle aspiration biopsy. 61
9285187 1997
48
Immunohistochemical metallothionein expression in thymoma: correlation with histological types and cellular origin. 61
9088953 1997
49
Primary thymic epithelial neoplasms showing combined features of thymoma and thymic carcinoma. A clinicopathologic study of 22 cases. 61
8944040 1996
50
Sweet's syndrome in a patient with idiopathic myelofibrosis and thymoma-myasthenia gravis-immunodeficiency complex: efficacy of treatment with etretinate. 61
8900854 1996

Variations for Spindle Cell Thymoma

Expression for Spindle Cell Thymoma

Search GEO for disease gene expression data for Spindle Cell Thymoma.

Pathways for Spindle Cell Thymoma

Pathways related to Spindle Cell Thymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 MUC1 KRT5 KRT13 DES
2
Show member pathways
11.17 KRT5 KRT13 DES

GO Terms for Spindle Cell Thymoma

Cellular components related to Spindle Cell Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 MUC1 KRT5 KRT13 ENO2 DES
2 intermediate filament cytoskeleton GO:0045111 9.16 KRT13 DES
3 intermediate filament GO:0005882 8.8 KRT5 KRT13 DES

Biological processes related to Spindle Cell Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton organization GO:0007010 8.8 KRT5 KRT13 DES

Sources for Spindle Cell Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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