MCID: SPN279
MIFTS: 20

Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Categories: Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

MalaCards integrated aliases for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

Name: Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor 12 15
Spindle Epithelial Tumour with Thymus-Like Differentiation Tumour 12
Settle Tumour 12
Settle Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050923

Summaries for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Disease Ontology : 12 A thyroid gland carcinoma that has material basis in compact bundles of long spindle epithelial cells that merge with tubulopapillary structures and/or mucinous glands.

MalaCards based summary : Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor, also known as spindle epithelial tumour with thymus-like differentiation tumour, is related to thyroid gland mucoepidermoid carcinoma and mucoepidermoid carcinoma. An important gene associated with Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor is TG (Thyroglobulin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. Affiliated tissues include thymus, thyroid and myeloid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Diseases related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 thyroid gland mucoepidermoid carcinoma 10.1 TG CALCA
2 mucoepidermoid carcinoma 10.1 TG CALCA
3 isthmus cancer 10.1 TG CALCA
4 substernal goiter 10.1 TG CALCA
5 goiter 10.1 TG CALCA
6 atypical follicular adenoma 10.1 TG CALCA
7 follicular adenoma 10.1 TG CALCA
8 thyroid sarcoma 10.1 TG CALCA
9 carotid body cancer 10.1 TG CALCA
10 nonencapsulated sclerosing carcinoma 10.1 TG CALCA
11 acute thyroiditis 10.1 TG CALCA
12 thyroiditis 10.1 TG CALCA
13 fetal adenoma 10.1 TG CALCA
14 thyroid angiosarcoma 10.1 TG CALCA
15 endometrial small cell carcinoma 10.1 TG KIT
16 endemic goiter 10.1 TG CALCA
17 nasal cavity olfactory neuroblastoma 10.1 TG CALCA
18 papillary thyroid microcarcinoma 10.1 TG CALCA
19 suppurative thyroiditis 10.1 TG CALCA
20 ovarian germ cell cancer 10.1 TG KIT
21 nontoxic goiter 10.0 TG CALCA
22 graves disease 1 10.0 TG CALCA
23 thyroid gland medullary carcinoma 10.0 TG CALCA
24 nodular goiter 10.0 TG CALCA
25 thyroid cancer, nonmedullary, 2 10.0 TG CALCA
26 parathyroid gland disease 10.0 TG CALCA
27 small cell carcinoma 10.0 KIT CALCA
28 thyroid gland disease 10.0 TG CALCA
29 multinodular goiter 10.0 TG CALCA
30 uterine corpus sarcoma 10.0 KIT CALCA
31 thyroid carcinoma, familial medullary 10.0 TG CALCA
32 thyroid carcinoma 10.0 TG CALCA
33 endocrine organ benign neoplasm 10.0 TG CALCA
34 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0 KIT DNTT
35 multiple endocrine neoplasia 10.0 TG CALCA
36 myoma 10.0 KIT CALCA
37 papillary carcinoma 10.0 TG CALCA
38 myeloid sarcoma 9.9 KIT DNTT
39 neuroendocrine carcinoma 9.9 KIT CALCA
40 small cell cancer of the lung 9.9 KIT CALCA
41 hyperthyroidism 9.9 TG CALCA
42 thyrotoxic exophthalmos 9.9 TG CD5
43 endocrine exophthalmos 9.9 TG CD5
44 merkel cell carcinoma 9.9 KIT DNTT
45 papillary thymic adenocarcinoma 9.9 TG CD5
46 hashimoto thyroiditis 9.9 TG CALCA
47 dendritic cell thymoma 9.9 TG CD5
48 thymic epithelial tumor 9.9 KIT CD5
49 lymphoepithelioma-like thymic carcinoma 9.9 KIT CD5
50 orbital disease 9.9 TG CD5

Graphical network of the top 20 diseases related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:



Diseases related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Symptoms & Phenotypes for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

GenomeRNAi Phenotypes related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.53 DNTT
2 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.53 DNTT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.53 DNTT
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.53 DNTT
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.53 KIT
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.53 DNTT KIT
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.53 DNTT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.53 KIT
9 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.53 DNTT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.53 KIT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-61 9.53 KIT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.53 DNTT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.53 KIT
14 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.53 KIT
15 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.53 KIT

Drugs & Therapeutics for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Search Clinical Trials , NIH Clinical Center for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Genetic Tests for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Anatomical Context for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

MalaCards organs/tissues related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

40
Thymus, Thyroid, Myeloid, Bone Marrow, Bone, Lung, Uterus

Publications for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Articles related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

# Title Authors PMID Year
1
SETTLE tumor of thyroid: Oldest case in literature. 61
30706893 2019
2
Rapid progression of SETTLE tumor with micrometastasis. 61
18237243 2008
3
Thyroid spindle epithelial tumor with thymus-like differentiation (the "SETTLE" tumor). An immunohistochemical and electron microscopic study. 61
7576592 1995

Variations for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Expression for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Search GEO for disease gene expression data for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor.

Pathways for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Pathways related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 KIT CD5
2 10.79 KIT DNTT CD5

GO Terms for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Molecular functions related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 TG CALCA

Sources for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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