MCID: SPN279
MIFTS: 20

Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

MalaCards integrated aliases for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

Name: Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor 12 15
Settle Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050923

Summaries for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Disease Ontology : 12 A thyroid gland carcinoma that has material basis in compact bundles of long spindle epithelial cells that merge with tubulopapillary structures and/or mucinous glands.

MalaCards based summary : Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor, also known as settle tumor, is related to thyroid gland mucoepidermoid carcinoma and mucoepidermoid carcinoma. An important gene associated with Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor is TG (Thyroglobulin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. Affiliated tissues include thyroid, thymus and myeloid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Diseases related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 thyroid gland mucoepidermoid carcinoma 10.1 TG CALCA
2 mucoepidermoid carcinoma 10.1 TG CALCA
3 thyroid sarcoma 10.1 TG CALCA
4 acute thyroiditis 10.1 TG CALCA
5 thyroiditis 10.1 TG CALCA
6 fetal adenoma 10.1 TG CALCA
7 nonencapsulated sclerosing carcinoma 10.1 TG CALCA
8 carotid body cancer 10.1 TG CALCA
9 hypoadrenalism 10.1 TG CALCA
10 thyroid angiosarcoma 10.1 TG CALCA
11 nasal cavity olfactory neuroblastoma 10.1 TG CALCA
12 endemic goiter 10.1 TG CALCA
13 goiter 10.1 TG CALCA
14 papillary thyroid microcarcinoma 10.1 TG CALCA
15 ovarian germ cell cancer 10.1 TG KIT
16 nontoxic goiter 10.1 TG CALCA
17 graves disease 1 10.1 TG CALCA
18 thyroid gland medullary carcinoma 10.1 TG CALCA
19 thyroid gland follicular carcinoma 10.1 TG CALCA
20 nodular goiter 10.1 TG CALCA
21 parathyroid gland disease 10.1 TG CALCA
22 thyroid gland disease 10.0 TG CALCA
23 autoimmune disease of endocrine system 10.0 TG CALCA
24 thyroid cancer, nonmedullary, 2 10.0 TG CALCA
25 salivary gland disease 10.0 TG KIT
26 multinodular goiter 10.0 TG CALCA
27 papillary thymic adenocarcinoma 10.0 TG CD5
28 thyroid carcinoma, familial medullary 10.0 TG CALCA
29 thyrotoxic exophthalmos 10.0 TG CD5
30 thyroid carcinoma 10.0 TG CALCA
31 uterus leiomyosarcoma 10.0 KIT CALCA
32 endocrine exophthalmos 10.0 TG CD5
33 follicular adenoma 10.0 TG CALCA
34 thymic carcinoma 10.0 KIT CD5
35 thymic epithelial tumor 10.0 KIT CD5
36 type c thymoma 10.0 KIT CD5
37 combined thymoma 10.0 KIT CD5
38 thymus clear cell carcinoma 10.0 KIT CD5
39 small cell carcinoma 10.0 KIT CALCA
40 endocrine organ benign neoplasm 10.0 TG CALCA
41 mediastinal cancer 9.9 KIT CD5
42 myoma 9.9 KIT CALCA
43 papillary carcinoma 9.9 TG CALCA
44 neuroendocrine carcinoma 9.9 KIT CALCA
45 hyperthyroidism 9.9 TG CALCA
46 small cell cancer of the lung 9.9 KIT CALCA
47 lymphatic system disease 9.8 KIT CD5
48 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.8 KIT DNTT
49 myeloid sarcoma 9.8 KIT DNTT
50 hashimoto thyroiditis 9.7 TG CALCA

Graphical network of the top 20 diseases related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:



Diseases related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Symptoms & Phenotypes for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

GenomeRNAi Phenotypes related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.58 DNTT KIT
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.58 DNTT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.58 DNTT
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.58 DNTT
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.58 KIT
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.58 DNTT KIT
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.58 DNTT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.58 KIT
9 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.58 DNTT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.58 DNTT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.58 KIT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.58 KIT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.58 DNTT
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.58 KIT
15 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.58 KIT
16 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.58 KIT

Drugs & Therapeutics for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Search Clinical Trials , NIH Clinical Center for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Genetic Tests for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Anatomical Context for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

MalaCards organs/tissues related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

40
Thyroid, Thymus, Myeloid, Bone, Bone Marrow, Lung, Salivary Gland

Publications for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Articles related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

# Title Authors PMID Year
1
SETTLE tumor of thyroid: Oldest case in literature. 61
30706893 2019
2
Rapid progression of SETTLE tumor with micrometastasis. 61
18237243 2008
3
Thyroid spindle epithelial tumor with thymus-like differentiation (the "SETTLE" tumor). An immunohistochemical and electron microscopic study. 61
7576592 1995

Variations for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Expression for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Search GEO for disease gene expression data for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor.

Pathways for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Pathways related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 KIT CD5
2 10.79 KIT DNTT CD5
3 10.68 KIT CD5

GO Terms for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Molecular functions related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 TG CALCA

Sources for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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