Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

MalaCards integrated aliases for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

Name: Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor ¹² ¹⁵

Spindle Epithelial Tumour with Thymus-Like Differentiation Tumour ¹²

Settle Tumour ¹²

Settle Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050923

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Summaries for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Disease Ontology : ¹² A thyroid gland carcinoma that has material basis in compact bundles of long spindle epithelial cells that merge with tubulopapillary structures and/or mucinous glands.

MalaCards based summary : Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor, also known as spindle epithelial tumour with thymus-like differentiation tumour, is related to thyroid gland mucoepidermoid carcinoma and mucoepidermoid carcinoma. An important gene associated with Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor is TG (Thyroglobulin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. Affiliated tissues include thymus, thyroid and myeloid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Diseases related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)

#	Related Disease	Score	Top Affiliating Genes
1	thyroid gland mucoepidermoid carcinoma	10.1	TG CALCA
2	mucoepidermoid carcinoma	10.1	TG CALCA
3	isthmus cancer	10.1	TG CALCA
4	substernal goiter	10.1	TG CALCA
5	goiter	10.1	TG CALCA
6	atypical follicular adenoma	10.1	TG CALCA
7	follicular adenoma	10.1	TG CALCA
8	thyroid sarcoma	10.1	TG CALCA
9	carotid body cancer	10.1	TG CALCA
10	nonencapsulated sclerosing carcinoma	10.1	TG CALCA
11	acute thyroiditis	10.1	TG CALCA
12	thyroiditis	10.1	TG CALCA
13	fetal adenoma	10.1	TG CALCA
14	thyroid angiosarcoma	10.1	TG CALCA
15	endometrial small cell carcinoma	10.1	TG KIT
16	endemic goiter	10.1	TG CALCA
17	nasal cavity olfactory neuroblastoma	10.1	TG CALCA
18	papillary thyroid microcarcinoma	10.1	TG CALCA
19	suppurative thyroiditis	10.1	TG CALCA
20	ovarian germ cell cancer	10.1	TG KIT
21	nontoxic goiter	10.0	TG CALCA
22	graves disease 1	10.0	TG CALCA
23	thyroid gland medullary carcinoma	10.0	TG CALCA
24	nodular goiter	10.0	TG CALCA
25	thyroid cancer, nonmedullary, 2	10.0	TG CALCA
26	parathyroid gland disease	10.0	TG CALCA
27	small cell carcinoma	10.0	KIT CALCA
28	thyroid gland disease	10.0	TG CALCA
29	multinodular goiter	10.0	TG CALCA
30	uterine corpus sarcoma	10.0	KIT CALCA
31	thyroid carcinoma, familial medullary	10.0	TG CALCA
32	thyroid carcinoma	10.0	TG CALCA
33	endocrine organ benign neoplasm	10.0	TG CALCA
34	acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	10.0	KIT DNTT
35	multiple endocrine neoplasia	10.0	TG CALCA
36	myoma	10.0	KIT CALCA
37	papillary carcinoma	10.0	TG CALCA
38	myeloid sarcoma	9.9	KIT DNTT
39	neuroendocrine carcinoma	9.9	KIT CALCA
40	small cell cancer of the lung	9.9	KIT CALCA
41	hyperthyroidism	9.9	TG CALCA
42	thyrotoxic exophthalmos	9.9	TG CD5
43	endocrine exophthalmos	9.9	TG CD5
44	merkel cell carcinoma	9.9	KIT DNTT
45	papillary thymic adenocarcinoma	9.9	TG CD5
46	hashimoto thyroiditis	9.9	TG CALCA
47	dendritic cell thymoma	9.9	TG CD5
48	thymic epithelial tumor	9.9	KIT CD5
49	lymphoepithelioma-like thymic carcinoma	9.9	KIT CD5
50	orbital disease	9.9	TG CD5

Graphical network of the top 20 diseases related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

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Symptoms & Phenotypes for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

GenomeRNAi Phenotypes related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor according to GeneCards Suite gene sharing:

²⁶ (show all 15)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	9.53	DNTT
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.53	DNTT
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-145	9.53	DNTT
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	9.53	DNTT
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.53	KIT
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	9.53	DNTT KIT
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.53	DNTT
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-170	9.53	KIT
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-182	9.53	DNTT
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	9.53	KIT
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-61	9.53	KIT
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.53	DNTT
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.53	KIT
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	9.53	KIT
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	9.53	KIT

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Drugs & Therapeutics for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Search Clinical Trials , NIH Clinical Center for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

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Genetic Tests for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

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Anatomical Context for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

MalaCards organs/tissues related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

⁴⁰

Thymus, Thyroid, Myeloid, Bone Marrow, Bone, Lung, Uterus

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Publications for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Articles related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor:

#	Title	Authors	PMID	Year
1	SETTLE tumor of thyroid: Oldest case in literature. ⁶¹	Nandini H...Kannan S	30706893	2019
2	Rapid progression of SETTLE tumor with micrometastasis. ⁶¹	Erickson ML...Reyes-Mugica M	18237243	2008
3	Thyroid spindle epithelial tumor with thymus-like differentiation (the "SETTLE" tumor). An immunohistochemical and electron microscopic study. ⁶¹	Hofman P...Thyss A	7576592	1995

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Genes for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Genes related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TG	Thyroglobulin	Protein Coding	5.31	DISEASES inferred ¹⁵
2	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	5.06	DISEASES inferred ¹⁵
3	DNTT	DNA Nucleotidylexotransferase	Protein Coding	3.98	DISEASES inferred ¹⁵
4	CD5	CD5 Molecule	Protein Coding	3.97	DISEASES inferred ¹⁵
5	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	3.41	DISEASES inferred ¹⁵

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Variations for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

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Expression for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Search GEO for disease gene expression data for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor.

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Pathways for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Pathways related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.02	KIT CD5
2	Hematopoietic cell lineage ³⁶	10.79	KIT DNTT CD5

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GO Terms for Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor

Molecular functions related to Spindle Epithelial Tumor with Thymus-Like Differentiation Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	8.62	TG CALCA

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