SCA10
MCID: SPN314
MIFTS: 51

Spinocerebellar Ataxia 10 (SCA10)

Categories: Ear diseases, Eye diseases, Fetal diseases, Genetic diseases, Liver diseases, Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Spinocerebellar Ataxia 10

MalaCards integrated aliases for Spinocerebellar Ataxia 10:

Name: Spinocerebellar Ataxia 10 58 54 76 30 13 6 74
Spinocerebellar Ataxia Type 10 12 25 54 60 15
Sca10 58 25 54 60 76
Ataxia, Spinocerebellar, Type 10 41

Characteristics:

Orphanet epidemiological data:

60
spinocerebellar ataxia type 10
Inheritance: Autosomal dominant; Age of onset: Adult;

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
genetic anticipation
reduced penetrance
age at onset 14 to 44 years
patients of brazilian origin have a pure cerebellar atrophy
patients of mexican or amerindian origin have a complicated phenotype with additional neurologic features
normal alleles have 10 to 29 repeats and pathologic alleles have 400 to 4,500 repeats


HPO:

33
spinocerebellar ataxia 10:
Onset and clinical course incomplete penetrance
Inheritance genetic anticipation autosomal dominant inheritance


GeneReviews:

25
Penetrance Penetrance is usually complete. however, apparent reduced penetrance has been reported [alonso et al 2006, matsuura et al 2006, raskin et al 2007]...

Classifications:

Orphanet: 60  
Rare neurological diseases


Summaries for Spinocerebellar Ataxia 10

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 98761Disease definitionSpinocerebellar ataxia type 10 (SCA10) is a subtype of type I autosomal dominant cerebellar ataxia (ADCA type I; see this term). It is characterized by slowly progressive cerebellar syndrome and epilepsy, sometimes mild pyramidal signs, peripheral neuropathy and neuropsychological disturbances.EpidemiologyPrevalence is unknown. Many kindreds have been found in Mexican and Brazilian populations. SCA10 is the second most common inherited ataxia in these two countries.Clinical descriptionAge of onset ranges from 18 to 45 years (mean age = 32.2 years). The most common type of epilepsy is generalized motor seizures, but partial motor or partial complex seizures can occur.EtiologySCA10 is caused by an ATTCT pentanucleotide repeat expansion in intron 9 of the ATXN10 gene (22q13). Exact pathogenesis has not been determined but RNA processing may be involved.PrognosisPrognosis is poor, especially for patients with refractory epilepsy. Exact disease duration is unknown. However, the mean disease duration can be estimated to be about 13 years.Visit the Orphanet disease page for more resources.

MalaCards based summary : Spinocerebellar Ataxia 10, also known as spinocerebellar ataxia type 10, is related to aceruloplasminemia and spinocerebellar ataxia, autosomal recessive 10, and has symptoms including seizures, gait ataxia and abnormality of extrapyramidal motor function. An important gene associated with Spinocerebellar Ataxia 10 is ATXN10 (Ataxin 10), and among its related pathways/superpathways are NGF Pathway and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. Affiliated tissues include eye, spinal cord and cerebellum, and related phenotypes are dysarthria and gait ataxia

Disease Ontology : 12 An autosomal dominant cerebellar ataxia that is characterized by gait ataxia, upper-limb ataxia, dysarthria and dysphagia, has material basis in mutation in the ATXN10 gene.

OMIM : 58 The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. A commonly accepted clinical classification (Harding, 1993) divides ADCAs into 3 different groups based on the presence or absence of associated symptoms such as brainstem signs or retinopathy. The presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia makes the diagnosis of ADCA I, the presence of retinopathy points to ADCA II, and the absence of associated signs to ADCA III. Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes. For a general discussion of autosomal dominant spinocerebellar ataxia, see SCA1 (164400). (603516)

UniProtKB/Swiss-Prot : 76 Spinocerebellar ataxia 10: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).

GeneReviews: NBK1175

Related Diseases for Spinocerebellar Ataxia 10

Diseases in the Spinocerebellar Ataxia 2 family:

Spinocerebellar Ataxia 31 Spinocerebellar Ataxia 29
Spinocerebellar Ataxia 34 Spinocerebellar Ataxia 1
Spinocerebellar Ataxia 7 Spinocerebellar Ataxia 6
Spinocerebellar Ataxia, Autosomal Recessive 2 Spinocerebellar Ataxia, Autosomal Recessive 3
Spinocerebellar Ataxia 4 Spinocerebellar Ataxia 5
Spinocerebellar Ataxia 10 Spinocerebellar Ataxia 12
Spinocerebellar Ataxia 11 Spinocerebellar Ataxia 13
Spinocerebellar Ataxia 14 Spinocerebellar Ataxia 15
Spinocerebellar Ataxia 17 Spinocerebellar Ataxia, Autosomal Recessive 4
Spinocerebellar Ataxia 19 Spinocerebellar Ataxia 21
Spinocerebellar Ataxia 18 Spinocerebellar Ataxia, Autosomal Recessive 6
Spinocerebellar Ataxia 20 Spinocerebellar Ataxia 25
Spinocerebellar Ataxia 8 Spinocerebellar Ataxia, Autosomal Recessive 7
Spinocerebellar Ataxia 26 Spinocerebellar Ataxia 27
Spinocerebellar Ataxia 23 Spinocerebellar Ataxia 28
Spinocerebellar Ataxia, Autosomal Recessive 8 Spinocerebellar Ataxia 9
Spinocerebellar Ataxia 30 Spinocerebellar Ataxia, Autosomal Recessive 10
Spinocerebellar Ataxia 35 Spinocerebellar Ataxia 32
Spinocerebellar Ataxia 36 Spinocerebellar Ataxia, Autosomal Recessive 11
Spinocerebellar Ataxia, Autosomal Recessive 12 Spinocerebellar Ataxia, Autosomal Recessive 13
Spinocerebellar Ataxia, Autosomal Recessive 14 Spinocerebellar Ataxia, Autosomal Recessive 15
Spinocerebellar Ataxia, Autosomal Recessive 16 Spinocerebellar Ataxia 37
Spinocerebellar Ataxia 38 Spinocerebellar Ataxia 40
Spinocerebellar Ataxia, Autosomal Recessive 17 Spinocerebellar Ataxia, Autosomal Recessive 18
Spinocerebellar Ataxia, Autosomal Recessive 20 Spinocerebellar Ataxia 41
Spinocerebellar Ataxia, Autosomal Recessive 21 Spinocerebellar Ataxia 42
Spinocerebellar Ataxia, Autosomal Recessive 22 Spinocerebellar Ataxia, Autosomal Recessive 23
Spinocerebellar Ataxia 43 Spinocerebellar Ataxia, Autosomal Recessive 24
Spinocerebellar Ataxia, Autosomal Recessive 25 Spinocerebellar Ataxia, Autosomal Recessive 26
Spinocerebellar Ataxia 44 Spinocerebellar Ataxia 45
Spinocerebellar Ataxia 46 Spinocerebellar Ataxia 47
Spinocerebellar Ataxia 48 Spinocerebellar Ataxia, Autosomal Recessive 27
Spinocerebellar Ataxia Type 19/22 Grid2-Related Spinocerebellar Ataxia
Spinocerebellar Ataxia Autosomal Recessive 5

Diseases related to Spinocerebellar Ataxia 10 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 aceruloplasminemia 29.9 ANO10 ATXN10 KCNC3
2 spinocerebellar ataxia, autosomal recessive 10 11.5
3 spinocerebellar ataxia 12 10.3
4 autosomal dominant cerebellar ataxia 10.3
5 fragile x tremor/ataxia syndrome 10.2
6 spinocerebellar ataxia 17 10.2
7 spinocerebellar ataxia 8 10.2
8 epilepsy 10.0
9 huntington disease 10.0
10 spinocerebellar ataxia 36 10.0
11 movement disease 10.0
12 ataxia and polyneuropathy, adult-onset 10.0
13 immature cataract 9.6 CCT3 CNBP

Graphical network of the top 20 diseases related to Spinocerebellar Ataxia 10:



Diseases related to Spinocerebellar Ataxia 10

Symptoms & Phenotypes for Spinocerebellar Ataxia 10

Human phenotypes related to Spinocerebellar Ataxia 10:

60 33 (show all 41)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dysarthria 60 33 hallmark (90%) Very frequent (99-80%) HP:0001260
2 gait ataxia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002066
3 progressive cerebellar ataxia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002073
4 dyskinesia 60 33 frequent (33%) Frequent (79-30%) HP:0100660
5 gait imbalance 60 33 frequent (33%) Frequent (79-30%) HP:0002141
6 dysmetria 60 33 frequent (33%) Frequent (79-30%) HP:0001310
7 intention tremor 60 33 frequent (33%) Frequent (79-30%) HP:0002080
8 dysdiadochokinesis 60 33 frequent (33%) Frequent (79-30%) HP:0002075
9 cerebellar atrophy 60 33 frequent (33%) Frequent (79-30%) HP:0001272
10 scanning speech 60 33 frequent (33%) Frequent (79-30%) HP:0002168
11 unsteady gait 60 33 frequent (33%) Frequent (79-30%) HP:0002317
12 impaired smooth pursuit 60 33 frequent (33%) Frequent (79-30%) HP:0007772
13 gaze-evoked nystagmus 60 33 frequent (33%) Frequent (79-30%) HP:0000640
14 eeg with generalized epileptiform discharges 60 33 frequent (33%) Frequent (79-30%) HP:0011198
15 generalized-onset seizure 33 frequent (33%) HP:0002197
16 depressivity 60 33 occasional (7.5%) Occasional (29-5%) HP:0000716
17 hyperreflexia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001347
18 sleep disturbance 60 33 occasional (7.5%) Occasional (29-5%) HP:0002360
19 babinski sign 60 33 occasional (7.5%) Occasional (29-5%) HP:0003487
20 focal impaired awareness seizure 60 33 occasional (7.5%) Occasional (29-5%) HP:0002384
21 aggressive behavior 60 33 occasional (7.5%) Occasional (29-5%) HP:0000718
22 status epilepticus 60 33 occasional (7.5%) Occasional (29-5%) HP:0002133
23 hyporeflexia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001265
24 generalized hypotonia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001290
25 lower limb spasticity 60 33 occasional (7.5%) Occasional (29-5%) HP:0002061
26 urinary urgency 60 33 occasional (7.5%) Occasional (29-5%) HP:0000012
27 apathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0000741
28 focal motor seizure 60 33 occasional (7.5%) Occasional (29-5%) HP:0011153
29 nystagmus 60 33 Frequent (79-30%) HP:0000639
30 seizures 33 HP:0001250
31 dysphagia 33 HP:0002015
32 abnormal pyramidal sign 33 HP:0007256
33 decreased nerve conduction velocity 33 HP:0000762
34 limb ataxia 33 HP:0002070
35 generalized seizures 60 Frequent (79-30%)
36 dementia 33 HP:0000726
37 abnormality of extrapyramidal motor function 33 HP:0002071
38 urinary incontinence 33 HP:0000020
39 incoordination 33 HP:0002311
40 morphological abnormality of the pyramidal tract 33 HP:0002062
41 kinetic tremor 60 Frequent (79-30%)

Symptoms via clinical synopsis from OMIM:

58
Head And Neck Eyes:
nystagmus
ocular movement abnormalities

Abdomen Gastrointestinal:
dysphagia

Neurologic Behavioral Psychiatric Manifestations:
depression

Neurologic Central Nervous System:
seizures
dysarthria
hyperreflexia
cognitive impairment
gait ataxia
more
Genitourinary Bladder:
urinary urgency
urinary incontinence

Neurologic Peripheral Nervous System:
nerve conduction abnormalities

Clinical features from OMIM:

603516

UMLS symptoms related to Spinocerebellar Ataxia 10:


seizures, gait ataxia, abnormality of extrapyramidal motor function, dysdiadochokinesis, scanning speech, urgency of micturition, abnormal pyramidal signs

GenomeRNAi Phenotypes related to Spinocerebellar Ataxia 10 according to GeneCards Suite gene sharing:

27 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 10 PLK1
2 Decreased substrate adherent cell growth GR00193-A-2 10 AURKB PLK1 PRKCD
3 Decreased substrate adherent cell growth GR00193-A-3 10 PLK1
4 Decreased substrate adherent cell growth GR00193-A-4 10 AURKB PLK1 NTRK1
5 Decreased viability GR00055-A-2 9.53 PLK1
6 Decreased viability GR00173-A 9.53 AURKB PLK1 PRKCD
7 Decreased viability GR00221-A-1 9.53 AURKB PRKCD
8 Decreased viability GR00221-A-2 9.53 AURKB PLK1 PRKCD
9 Decreased viability GR00221-A-4 9.53 AURKB
10 Decreased viability GR00231-A 9.53 PLK1
11 Decreased viability GR00240-S-1 9.53 PLK1
12 Decreased viability GR00301-A 9.53 PLK1
13 Decreased viability GR00402-S-2 9.53 AURKB PLK1 PRKCD
14 Decreased vesicular stomatitis virus (VSV) infection GR00356-A-1 9.13 AURKB MAP2K1 PLK1

MGI Mouse Phenotypes related to Spinocerebellar Ataxia 10:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.36 ATXN10 AURKB CCT3 CNBP KCNC3 MAP2K1

Drugs & Therapeutics for Spinocerebellar Ataxia 10

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Troriluzole in Adult Subjects With Spinocerebellar Ataxia Recruiting NCT03701399 Phase 3 troriluzole;Placebos
2 Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 10 (SCA10) Completed NCT00004306
3 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Spinocerebellar Ataxia 10

Genetic Tests for Spinocerebellar Ataxia 10

Genetic tests related to Spinocerebellar Ataxia 10:

# Genetic test Affiliating Genes
1 Spinocerebellar Ataxia 10 30 ATXN10

Anatomical Context for Spinocerebellar Ataxia 10

MalaCards organs/tissues related to Spinocerebellar Ataxia 10:

42
Eye, Spinal Cord, Cerebellum, Skin, Liver

Publications for Spinocerebellar Ataxia 10

Articles related to Spinocerebellar Ataxia 10:

(show all 25)
# Title Authors Year
1
Olfactory Function in SCA10. ( 29922950 )
2019
2
Frequency of SCA8, SCA10, SCA12, SCA36, FXTAS and C9orf72 repeat expansions in SCA patients negative for the most common SCA subtypes. ( 29316893 )
2018
3
Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions. ( 28423040 )
2017
4
Haplotype Study in SCA10 Families Provides Further Evidence for a Common Ancestral Origin of the Mutation. ( 28905220 )
2017
5
Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10. ( 27248057 )
2016
6
Spinocerebellar ataxia-10 with paranoid schizophrenia. ( 25745322 )
2015
7
Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10). ( 26039897 )
2015
8
SMRT Sequencing of Long Tandem Nucleotide Repeats in SCA10 Reveals Unique Insight of Repeat Expansion Structure. ( 26295943 )
2015
9
Analysis of SCA8, SCA10, SCA12, SCA17 and SCA19 in patients with unknown spinocerebellar ataxia: a Thai multicentre study. ( 26374734 )
2015
10
The unique co-occurrence of spinocerebellar ataxia type 10 (SCA10) and Huntington disease. ( 23083689 )
2013
11
Expansion of the Spinocerebellar ataxia type 10 (SCA10) repeat in a patient with Sioux Native American ancestry. ( 24278426 )
2013
12
Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: a toxic RNA gain-of-function model. ( 22065565 )
2012
13
Investigation of SCA10 in the Cypriot population: further exclusion of SCA dynamic repeat mutations. ( 23026538 )
2012
14
Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10. ( 20548952 )
2010
15
EFNS guidelines on the molecular diagnosis of ataxias and spastic paraplegias. ( 20050888 )
2010
16
Ancestral origin of the ATTCT repeat expansion in spinocerebellar ataxia type 10 (SCA10). ( 19234597 )
2009
17
FXTAS, SCA10, and SCA17 in American patients with movement disorders. ( 15889413 )
2005
18
Recent progress in spinocerebellar ataxia type-10 (SCA10). ( 15895557 )
2005
19
Clinical phenotype of Brazilian families with spinocerebellar ataxia 10. ( 15505178 )
2004
20
Detection of large pathogenic expansions in FRDA1, SCA10, and SCA12 genes using a simple fluorescent repeat-primed PCR assay. ( 15096564 )
2004
21
Somatic and germline instability of the ATTCT repeat in spinocerebellar ataxia type 10. ( 15127363 )
2004
22
Unpaired structures in SCA10 (ATTCT)n.(AGAAT)n repeats. ( 12589756 )
2003
23
SCA10 and ATTCT repeat expansion: clinical features and molecular aspects. ( 14526179 )
2003
24
Genetic localization of the Ca2+ channel gene CACNG2 near SCA10 on chromosome 22q13. ( 10643919 )
2000
25
Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10. ( 11017075 )
2000

Variations for Spinocerebellar Ataxia 10

ClinVar genetic disease variations for Spinocerebellar Ataxia 10:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(10_32) NT expansion Benign rs60726084 GRCh37 Chromosome 22, 46191240: 46191244
2 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(10_32) NT expansion Benign rs60726084 GRCh38 Chromosome 22, 45795360: 45795364
3 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(360_370) NT expansion Pathogenic GRCh37 Chromosome 22, 46191240: 46191244
4 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(360_370) NT expansion Pathogenic GRCh38 Chromosome 22, 45795360: 45795364
5 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(400_760) NT expansion Pathogenic GRCh37 Chromosome 22, 46191240: 46191244
6 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(400_760) NT expansion Pathogenic GRCh38 Chromosome 22, 45795360: 45795364
7 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(800_4500) NT expansion Pathogenic GRCh37 Chromosome 22, 46191240: 46191244
8 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(800_4500) NT expansion Pathogenic GRCh38 Chromosome 22, 45795360: 45795364
9 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(850) short repeat Pathogenic GRCh37 Chromosome 22, 46191240: 46191240
10 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT(850) short repeat Pathogenic GRCh38 Chromosome 22, 45795360: 45795360
11 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT[280] NT expansion Pathogenic GRCh37 Chromosome 22, 46191240: 46191244
12 ATXN10 NM_013236.3(ATXN10): c.1173+54822_1173+54826ATTCT[280] NT expansion Pathogenic GRCh38 Chromosome 22, 45795360: 45795364

Expression for Spinocerebellar Ataxia 10

Search GEO for disease gene expression data for Spinocerebellar Ataxia 10.

Pathways for Spinocerebellar Ataxia 10

Pathways related to Spinocerebellar Ataxia 10 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.61 MAP2K1 NTRK1 PRKCD
2 11.49 MAP2K1 NTRK1 PRKCD
3 10.86 AURKB CCT3 PLK1
4
Show member pathways
10.81 MAP2K1 PRKCD
5 10.37 AURKB MAP2K1 PLK1

GO Terms for Spinocerebellar Ataxia 10

Cellular components related to Spinocerebellar Ataxia 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.96 ATXN10 AURKB CCT3 CNBP GGCT MAP2K1
2 cytoskeleton GO:0005856 9.63 AURKB CCT3 KCNC3 MAP2K1 PLK1 RAD51
3 cytoplasm GO:0005737 9.4 ATXN10 AURKB CCT3 CNBP HNRNPK KCNC3
4 spindle midzone GO:0051233 9.32 AURKB PLK1
5 condensed nuclear chromosome, centromeric region GO:0000780 8.96 AURKB PLK1

Biological processes related to Spinocerebellar Ataxia 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.54 MAP2K1 NTRK1 PRKCD
2 phosphorylation GO:0016310 9.35 AURKB MAP2K1 NTRK1 PLK1 PRKCD
3 mitotic spindle assembly checkpoint GO:0007094 9.32 AURKB PLK1
4 cellular senescence GO:0090398 9.26 MAP2K1 PRKCD
5 positive regulation of proteolysis GO:0045862 9.16 OGT PLK1
6 protein phosphorylation GO:0006468 9.02 AURKB MAP2K1 NTRK1 PLK1 PRKCD

Molecular functions related to Spinocerebellar Ataxia 10 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.72 AURKB MAP2K1 NTRK1 PLK1 PRKCD
2 protein serine/threonine kinase activity GO:0004674 9.71 AURKB MAP2K1 PLK1 PRKCD
3 nucleotide binding GO:0000166 9.67 AURKB MAP2K1 PLK1 RAD51
4 protein serine/threonine/tyrosine kinase activity GO:0004712 9.43 AURKB MAP2K1
5 single-stranded DNA binding GO:0003697 9.43 CNBP HNRNPK RAD51
6 protein kinase activity GO:0004672 9.35 AURKB MAP2K1 NTRK1 PLK1 PRKCD
7 kinase binding GO:0019900 9.33 AURKB NTRK1 PRKCD
8 ATP binding GO:0005524 9.17 AURKB CCT3 MAP2K1 NTRK1 PLK1 PRKCD

Sources for Spinocerebellar Ataxia 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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