SCA31
MCID: SPN103
MIFTS: 38

Spinocerebellar Ataxia 31 (SCA31)

Categories: Ear diseases, Eye diseases, Fetal diseases, Genetic diseases, Liver diseases, Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Spinocerebellar Ataxia 31

MalaCards integrated aliases for Spinocerebellar Ataxia 31:

Name: Spinocerebellar Ataxia 31 56 52 73 29 13 6 71
Spinocerebellar Ataxia Type 31 12 52 58 15
Sca31 56 52 58 73
Spinocerebellar Ataxia 16q22-Linked 52 73
Pure Spinocerebellar Ataxia Japanese Type 73
Spinocerebellar Ataxia, 16q22-Linked 56
Ataxia, Spinocerebellar, Type 31 39
Sca4 Pure Japanese Type 73

Characteristics:

Orphanet epidemiological data:

58
spinocerebellar ataxia type 31
Inheritance: Autosomal dominant; Age of onset: Adolescent,Adult,Childhood,Elderly; Age of death: elderly;

OMIM:

56
Inheritance:
autosomal dominant

Miscellaneous:
late adult onset (after age 55 years)
earlier onset is rare


HPO:

31
spinocerebellar ataxia 31:
Inheritance autosomal dominant inheritance
Onset and clinical course late onset


Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0050980
OMIM 56 117210
OMIM Phenotypic Series 56 PS164400
MeSH 43 D020754
ICD10 via Orphanet 33 G11.8
UMLS via Orphanet 72 C1861736
Orphanet 58 ORPHA217012
MedGen 41 C1861736
UMLS 71 C1861736

Summaries for Spinocerebellar Ataxia 31

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 217012 Definition Spinocerebellar ataxia type 31 (SCA31) is a very rare subtype of autosomal dominant cerebellar ataxia type III (ADCA type III; see this term) characterized by the late-onset of cerebral ataxia, dysarthria and horizontal gaze nystagmus , and that is occasionally accompanied by pyramidal signs, tremor, decreased vibration sense and hearing difficulties. Epidemiology SCA31 is the third most common form of ADCA (see this term) in Japan, where more than 20 families have been reported to date. It is rarely found in other Asian countries and is extremely rare in Western countries. Clinical description The mean age of disease onset is 58 years but it can present between the ages of 8 to 83 years. Ataxia, dysarthria, and horizontal gaze nystagmus are the common manifestations of SCA31 and the disease duration can be more than 10 years. Less common manifestations include pyramidal signs, tremor, decreased vibration sense, and hearing difficulties. Etiology SCA31 is due to non-coding pentanucleotide repeat expansions in the BEAN1 gene (16q21), encoding protein BEAN1. Genetic counseling SCA31 is inherited autosomal dominantly with incomplete penetrance and genetic counseling is possible. Visit the Orphanet disease page for more resources.

MalaCards based summary : Spinocerebellar Ataxia 31, also known as spinocerebellar ataxia type 31, is related to spinocerebellar ataxia 1 and spinocerebellar ataxia 36, and has symptoms including gait ataxia An important gene associated with Spinocerebellar Ataxia 31 is BEAN1 (Brain Expressed Associated With NEDD4 1). Affiliated tissues include cerebellum, eye and spinal cord, and related phenotypes are dysarthria and gait ataxia

Disease Ontology : 12 An autosomal dominant cerebellar ataxia that is characterized by late-onset ataxia, dysarthria and horizontal nystagmus, has material basis in repeat expansion mutation in the BEAN1 gene.

UniProtKB/Swiss-Prot : 73 Spinocerebellar ataxia 31: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA31 belongs to the autosomal dominant cerebellar ataxias type III (ADCA III) which are characterized by pure cerebellar ataxia without additional signs.

More information from OMIM: 117210 PS164400

Related Diseases for Spinocerebellar Ataxia 31

Diseases in the Spinocerebellar Ataxia 6 family:

Spinocerebellar Ataxia 31 Spinocerebellar Ataxia 29
Spinocerebellar Ataxia 34 Spinocerebellar Ataxia 1
Spinocerebellar Ataxia 7 Spinocerebellar Ataxia 2
Spinocerebellar Ataxia, Autosomal Recessive 2 Spinocerebellar Ataxia, Autosomal Recessive 3
Spinocerebellar Ataxia 4 Spinocerebellar Ataxia 5
Spinocerebellar Ataxia 10 Spinocerebellar Ataxia 12
Spinocerebellar Ataxia 11 Spinocerebellar Ataxia 13
Spinocerebellar Ataxia 14 Spinocerebellar Ataxia 15
Spinocerebellar Ataxia 17 Spinocerebellar Ataxia, Autosomal Recessive 4
Spinocerebellar Ataxia 19 Spinocerebellar Ataxia 21
Spinocerebellar Ataxia 18 Spinocerebellar Ataxia, Autosomal Recessive 6
Spinocerebellar Ataxia 20 Spinocerebellar Ataxia 25
Spinocerebellar Ataxia 8 Spinocerebellar Ataxia, Autosomal Recessive 7
Spinocerebellar Ataxia 26 Spinocerebellar Ataxia 27
Spinocerebellar Ataxia 23 Spinocerebellar Ataxia 28
Spinocerebellar Ataxia, Autosomal Recessive 8 Spinocerebellar Ataxia 9
Spinocerebellar Ataxia 30 Spinocerebellar Ataxia, Autosomal Recessive 10
Spinocerebellar Ataxia 35 Spinocerebellar Ataxia 32
Spinocerebellar Ataxia 36 Spinocerebellar Ataxia, Autosomal Recessive 11
Spinocerebellar Ataxia, Autosomal Recessive 12 Spinocerebellar Ataxia, Autosomal Recessive 13
Spinocerebellar Ataxia, Autosomal Recessive 14 Spinocerebellar Ataxia, Autosomal Recessive 15
Spinocerebellar Ataxia, Autosomal Recessive 16 Spinocerebellar Ataxia 37
Spinocerebellar Ataxia 38 Spinocerebellar Ataxia 40
Spinocerebellar Ataxia, Autosomal Recessive 17 Spinocerebellar Ataxia, Autosomal Recessive 18
Spinocerebellar Ataxia, Autosomal Recessive 20 Spinocerebellar Ataxia 41
Spinocerebellar Ataxia, Autosomal Recessive 21 Spinocerebellar Ataxia 42
Spinocerebellar Ataxia, Autosomal Recessive 22 Spinocerebellar Ataxia, Autosomal Recessive 23
Spinocerebellar Ataxia 43 Spinocerebellar Ataxia, Autosomal Recessive 24
Spinocerebellar Ataxia, Autosomal Recessive 25 Spinocerebellar Ataxia, Autosomal Recessive 26
Spinocerebellar Ataxia 44 Spinocerebellar Ataxia 45
Spinocerebellar Ataxia 46 Spinocerebellar Ataxia 47
Spinocerebellar Ataxia 48 Spinocerebellar Ataxia, Autosomal Recessive 27
Spinocerebellar Ataxia Type 19/22 Grid2-Related Spinocerebellar Ataxia
Spinocerebellar Ataxia Autosomal Recessive 5

Diseases related to Spinocerebellar Ataxia 31 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 spinocerebellar ataxia 1 31.1 CACNA1A ATXN3 ATXN10
2 spinocerebellar ataxia 36 30.0 NOP56 ATXN10
3 spinocerebellar ataxia 6 29.9 CACNA1A ATXN3
4 machado-joseph disease 29.4 CACNA1A ATXN3
5 dentatorubral-pallidoluysian atrophy 29.3 CACNA1A ATXN3 ATXN10
6 hereditary ataxia 28.3 NOP56 CACNA1A BEAN1 ATXN3 ATXN10
7 aceruloplasminemia 27.9 PLEKHG4 NOP56 NEDD4 CACNA1A ATXN3 ATXN10
8 autosomal dominant cerebellar ataxia 27.8 TK2 PLEKHG4 NOP56 CACNA1A ATXN3 ATXN10
9 mitochondrial dna depletion syndrome 7 11.6
10 dystonia 10.3
11 spinocerebellar degeneration 10.3
12 autosomal dominant cerebellar ataxia type iii 10.2 PLEKHG4 CACNA1A
13 multiple system atrophy 1 10.1
14 spinocerebellar ataxia 4 10.1
15 motor neuron disease 10.1
16 creutzfeldt-jakob disease 10.1
17 respiratory failure 10.1
18 dementia 10.1
19 hereditary spastic paraplegia 10.1
20 blepharospasm 10.1
21 neuromyelitis optica 10.1
22 rem sleep behavior disorder 10.1
23 pathologic nystagmus 10.1
24 neuromyelitis optica spectrum disorder 10.1
25 ataxia and polyneuropathy, adult-onset 10.1
26 paraplegia 10.1
27 primary cerebellar degeneration 9.8 CACNA1A ATXN3
28 spinocerebellar ataxia 38 9.8 CACNA1A ATXN3
29 mental retardation, x-linked, with cerebellar hypoplasia and distinctive facial appearance 9.8 CACNA1A ATXN3
30 myotonic dystrophy 2 9.8 NOP56 ATXN10
31 episodic ataxia, type 2 9.8 CACNA1A ATXN3
32 spinocerebellar ataxia 30 9.8 TK2 PLEKHG4 NOP56
33 episodic ataxia 9.8 CACNA1A ATXN3
34 spinocerebellar ataxia 17 9.7 CACNA1A ATXN3
35 spinocerebellar ataxia 12 9.7 CACNA1A ATXN3
36 ocular motility disease 9.7 CACNA1A ATXN3
37 myotonic disease 9.7 ATXN3 ATXN10
38 spinal and bulbar muscular atrophy, x-linked 1 9.6 CACNA1A ATXN3
39 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 9.6 NOP56 ATXN10
40 spinocerebellar ataxia 8 9.6 ATXN3 ATXN10
41 dystonia 12 9.6 CACNA1A ATXN3
42 myotonic dystrophy 1 9.6 ATXN3 ATXN10
43 kearns-sayre syndrome 9.5 TK2 CACNA1A ATXN3
44 spinocerebellar ataxia 2 9.4 CACNA1A ATXN3 ATXN10
45 contractures, pterygia, and variable skeletal fusions syndrome 1a 9.4 CACNA1A ATXN3 ATXN10
46 movement disease 9.3 CACNA1A ATXN3
47 x-linked hereditary ataxia 9.3 NOP56 ATXN3 ATXN10
48 spinocerebellar ataxia 10 9.3 NOP56 ATXN3 ATXN10
49 fragile x-associated tremor/ataxia syndrome 9.3 NOP56 ATXN3 ATXN10
50 huntington disease-like 2 9.3 NOP56 ATXN3 ATXN10

Graphical network of the top 20 diseases related to Spinocerebellar Ataxia 31:



Diseases related to Spinocerebellar Ataxia 31

Symptoms & Phenotypes for Spinocerebellar Ataxia 31

Human phenotypes related to Spinocerebellar Ataxia 31:

58 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dysarthria 58 31 hallmark (90%) Very frequent (99-80%) HP:0001260
2 gait ataxia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002066
3 cerebellar atrophy 58 31 hallmark (90%) Very frequent (99-80%) HP:0001272
4 nystagmus 58 31 frequent (33%) Frequent (79-30%) HP:0000639
5 hyporeflexia 58 31 frequent (33%) Frequent (79-30%) HP:0001265
6 gaze-evoked horizontal nystagmus 31 frequent (33%) HP:0007979
7 spasticity 58 31 occasional (7.5%) Occasional (29-5%) HP:0001257
8 tremor 58 31 occasional (7.5%) Occasional (29-5%) HP:0001337
9 hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000365
10 hyperactive deep tendon reflexes 58 31 occasional (7.5%) Occasional (29-5%) HP:0006801
11 impaired vibratory sensation 58 31 occasional (7.5%) Occasional (29-5%) HP:0002495
12 sensorineural hearing impairment 31 occasional (7.5%) HP:0000407
13 ataxia 31 HP:0001251
14 hyperreflexia 58 Occasional (29-5%)
15 limb ataxia 31 HP:0002070

Symptoms via clinical synopsis from OMIM:

56
Neurologic Central Nervous System:
nystagmus
dysarthria
gait ataxia
limb ataxia
cerebellar atrophy
more
Head And Neck Eyes:
gaze-evoked horizontal nystagmus (not always present)

Head And Neck Ears:
hearing loss, late-onset sensorineural, mild-to moderate (less common)

Clinical features from OMIM:

117210

UMLS symptoms related to Spinocerebellar Ataxia 31:


gait ataxia

GenomeRNAi Phenotypes related to Spinocerebellar Ataxia 31 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased infection with West Nile virus (WNV) GR00348-A-2 9.13 BEAN1 CACNA1A NOP56
2 Decreased West Nile virus (WNV) infection GR00348-A-3 8.8 BEAN1 CACNA1A NOP56

Drugs & Therapeutics for Spinocerebellar Ataxia 31

Search Clinical Trials , NIH Clinical Center for Spinocerebellar Ataxia 31

Genetic Tests for Spinocerebellar Ataxia 31

Genetic tests related to Spinocerebellar Ataxia 31:

# Genetic test Affiliating Genes
1 Spinocerebellar Ataxia 31 29 BEAN1

Anatomical Context for Spinocerebellar Ataxia 31

MalaCards organs/tissues related to Spinocerebellar Ataxia 31:

40
Cerebellum, Eye, Spinal Cord, Brain, Testes

Publications for Spinocerebellar Ataxia 31

Articles related to Spinocerebellar Ataxia 31:

(show top 50) (show all 61)
# Title Authors PMID Year
1
Spinocerebellar ataxia type 31 is associated with "inserted" penta-nucleotide repeats containing (TGGAA)n. 61 56 6
19878914 2009
2
Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia. 6 56
17611710 2007
3
16q-linked autosomal dominant cerebellar ataxia: a clinical and genetic study. 6 56
16780885 2006
4
A -16C>T substitution in the 5' UTR of the puratrophin-1 gene is prevalent in autosomal dominant cerebellar ataxia in Nagano. 56 6
16614795 2006
5
An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domains. 6 56
16001362 2005
6
EFNS guidelines on the molecular diagnosis of ataxias and spastic paraplegias. 6
20050888 2010
7
Clinical and genetic characterization of 16q-linked autosomal dominant spinocerebellar ataxia in South Kyushu, Japan. 56
19444286 2009
8
Spectrum and prevalence of autosomal dominant spinocerebellar ataxia in Hokkaido, the northern island of Japan: a study of 113 Japanese families. 56
17805477 2007
9
A clinical, genetic, and neuropathologic study in a family with 16q-linked ADCA type III. 56
16116133 2005
10
Fine mapping of 16q-linked autosomal dominant cerebellar ataxia type III in Japanese families. 56
15455264 2004
11
Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ADCA) type III in Japan. 56
12624721 2003
12
A gene on SCA4 locus causes dominantly inherited pure cerebellar ataxia. 56
10822439 2000
13
Hereditary Ataxia Overview 6
20301317 1998
14
Autosomal dominant pure cerebellar ataxia. Neurological and genetic study. 56
1486455 1992
15
The clinical features and classification of the late onset autosomal dominant cerebellar ataxias. A study of 11 families, including descendants of the 'the Drew family of Walworth'. 56
7066668 1982
16
Hereditary cerebello-olivary degeneration of late onset. 56
5535038 1970
17
Spinocerebellar ataxia type 10 (SCA10): Mutation analysis and common haplotype based inference suggest its rarity in Indian population. 61
31737797 2019
18
Molecular Mechanisms and Future Therapeutics for Spinocerebellar Ataxia Type 31 (SCA31). 61
31755042 2019
19
Impaired Adaptive Motor Learning Is Correlated With Cerebellar Hemispheric Gray Matter Atrophy in Spinocerebellar Ataxia Patients: A Voxel-Based Morphometry Study. 61
31803128 2019
20
Spinocerebellar Ataxia Type 31 with Blepharospasm. 61
29434122 2018
21
[Analysis of spinocerebellar ataxia type 31 related mutations among patients from mainland China]. 61
29896721 2018
22
Case Report: A patient with spinocerebellar ataxia type 31 and sporadic Creutzfeldt-Jakob disease. 61
29411683 2018
23
Sequence configuration of spinocerebellar ataxia type 8 repeat expansions in a Japanese cohort of 797 ataxia subjects. 61
29111027 2017
24
Inter-generational instability of inserted repeats during transmission in spinocerebellar ataxia type 31. 61
28638142 2017
25
[Overview of Hereditary Spinocerebellar Ataxias in Japan]. 61
28819072 2017
26
Neuromyelitis Optica Spectrum Disorder Coinciding with Spinocerebellar Ataxia Type 31. 61
28626410 2017
27
Natural History of Spinocerebellar Ataxia Type 31: a 4-Year Prospective Study. 61
27830516 2017
28
SCA31 Flies Perform in a Balancing Act between RAN Translation and RNA-Binding Proteins. 61
28384473 2017
29
Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31. 61
28343865 2017
30
Co-existence of spastic paraplegia-30 with novel KIF1A mutation and spinocerebellar ataxia 31 with intronic expansion of BEAN and TK2 in a family. 61
28017198 2017
31
[Recent advances in clinical and genetic research of spinocerebellar ataxia type 36]. 61
26663071 2015
32
When should we test patients with familial ataxias for SCA31? A misdiagnosed condition outside Japan? 61
26033715 2015
33
Autopsy case of spinocerebellar ataxia type 31 with severe dementia at the terminal stage. 61
25495291 2015
34
Visual scanning area is abnormally enlarged in hereditary pure cerebellar ataxia. 61
25231433 2015
35
Rare frequency of downbeat positioning nystagmus in spinocerebellar ataxia type 31. 61
25684342 2015
36
Clinical characteristics of combined cases of spinocerebellar ataxia types 6 and 31. 61
26004545 2015
37
The 3-second rule in hereditary pure cerebellar ataxia: a synchronized tapping study. 61
25706752 2015
38
Distinctive features of degenerating Purkinje cells in spinocerebellar ataxia type 31. 61
24344778 2014
39
[The utility of voxel-based morphometry in the diagnosis of spinocerebellar degeneration]. 61
24899352 2014
40
Rapid detection of expanded short tandem repeats in personal genomics using hybrid sequencing. 61
24215022 2014
41
[A case of 77-year-old male with spinocerebellar ataxia type 31 with left dominant dystonia]. 61
25142535 2014
42
Top-down but not bottom-up visual scanning is affected in hereditary pure cerebellar ataxia. 61
25545148 2014
43
Voiding Dysfunction in Spinocerebellar Ataxia Type 31. 61
26663503 2014
44
[Clinical features and MRI findings in spinocerebellar ataxia type 31 (SCA31) comparing with spinocerebellar ataxia type 6 (SCA6)]. 61
24990830 2014
45
Abnormal RNA structures (RNA foci) containing a penta-nucleotide repeat (UGGAA)n in the Purkinje cell nucleus is associated with spinocerebellar ataxia type 31 pathogenesis. 61
23607545 2013
46
Autosomal dominant cerebellar ataxia type III: a review of the phenotypic and genotypic characteristics. 61
23331413 2013
47
Acoustic impairment is a distinguishable clinical feature of Asidan/SCA36. 61
23140984 2013
48
Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31. 61
22992774 2012
49
Brain pathology of spinocerebellar ataxias. 61
22684686 2012
50
Spinocerebellar ataxia type 31 exists in northeast China. 61
22353852 2012

Variations for Spinocerebellar Ataxia 31

ClinVar genetic disease variations for Spinocerebellar Ataxia 31:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 BEAN1 BEAN1, 2.5- TO 3.8-KB INSinsertion Pathogenic 733
2 PLEKHG4 NM_001129729.3(PLEKHG4):c.-16C>TSNV Uncertain significance 1635 rs886041026 16:67313932-67313932 16:67280029-67280029

Expression for Spinocerebellar Ataxia 31

Search GEO for disease gene expression data for Spinocerebellar Ataxia 31.

Pathways for Spinocerebellar Ataxia 31

GO Terms for Spinocerebellar Ataxia 31

Sources for Spinocerebellar Ataxia 31

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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