ES
MCID: SPR013
MIFTS: 33

Spiradenoma (ES)

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Spiradenoma

MalaCards integrated aliases for Spiradenoma:

Name: Spiradenoma 12 15
Eccrine Spiradenoma 12 20 70
Benign Eccrine Spiradenoma 12 20
Eccrine Spiradenoma of Skin 12
Eccrine Spiradenoma, Benign 20
Es 20

Classifications:



External Ids:

Disease Ontology 12 DOID:5444
NCIt 50 C4170
SNOMED-CT 67 403938001
UMLS 70 C0334347

Summaries for Spiradenoma

MalaCards based summary : Spiradenoma, also known as eccrine spiradenoma, is related to malignant spiradenoma and brooke-spiegler syndrome. An important gene associated with Spiradenoma is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Cytoskeletal Signaling and Interleukin-4 and 13 signaling. Affiliated tissues include skin, smooth muscle and breast, and related phenotype is homeostasis/metabolism.

Wikipedia : 73 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

Related Diseases for Spiradenoma

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 354)
# Related Disease Score Top Affiliating Genes
1 malignant spiradenoma 32.7 TP53 KRT7 CYLD
2 brooke-spiegler syndrome 31.2 VIM TP53 KRT7 KRT14 CYLD
3 skin benign neoplasm 30.5 KRT7 KRT14 CYLD
4 eccrine acrospiroma 30.3 KRT7 KRT15
5 apocrine adenocarcinoma 30.0 MUC1 KRT7
6 sweat gland cancer 30.0 TP53 KRT7 KRT15
7 sweat gland benign neoplasm 29.9 TP53 KRT7 KRT14 CYLD
8 juvenile xanthogranuloma 29.9 S100B S100A1
9 syringoma 29.6 VIM S100B S100A1 MUC1 KRT7
10 basal cell carcinoma 29.6 TP53 KRT7 KRT15 KRT14 CYLD
11 hidradenoma 29.6 VIM MUC1 KRT7 KRT15
12 pilomatrixoma 29.5 S100B MUC1 KRT15 KRT14
13 angiosarcoma 29.3 VIM TP53 MUC1 KRT7
14 syringocystadenoma papilliferum 29.3 VIM S100B MUC1 ACTC1
15 chondrosarcoma 29.2 VIM S100B S100A1 MUC1
16 glomus tumor 29.2 VIM TP53 S100A1 MUC1 ACTC1
17 carcinosarcoma 29.1 VIM TP53 S100A1 MUC1 KRT7 ACTC1
18 spindle cell sarcoma 29.1 VIM S100B MUC1 KRT7 ACTC1
19 epithelial-myoepithelial carcinoma 29.0 VIM TP53 KRT7 KRT14 ACTC1
20 dermatofibrosarcoma protuberans 28.9 VIM TP53 S100B S100A1 ACTC1
21 myoepithelial carcinoma 28.7 VIM TP53 MUC1 KRT7 KRT14 ACTC1
22 rhabdomyosarcoma 28.6 VIM TP53 S100B S100A1 KRT7 ACTC1
23 neurofibroma 28.6 VIM TP53 S100B S100A1 MUC1 ACTC1
24 leiomyosarcoma 28.6 VIM TP53 S100B S100A1 MUC1 ACTC1
25 adenoid cystic carcinoma 28.4 VIM TP53 S100B S100A1 MUC1 KRT7
26 breast malignant eccrine spiradenoma 11.3
27 benign eccrine breast spiradenoma 11.1
28 adnexal spiradenoma/cylindroma of a sweat gland 11.1
29 anus basaloid carcinoma 10.4 KRT7 CYLD
30 oncocytic breast carcinoma 10.3 KRT7 KRT14
31 ceruminous adenocarcinoma 10.3 KRT7 KRT14
32 benign breast adenomyoepithelioma 10.3 KRT7 KRT14
33 sclerosing perineurioma 10.3 S100B MUC1
34 rare tumor 10.3
35 localized hypertrophic neuropathy 10.3 S100B MUC1
36 reticular perineurioma 10.3 S100B MUC1
37 intracranial cysts 10.3 S100B MUC1
38 squamous cell bile duct carcinoma 10.3 KRT7 KRT14
39 breast metaplastic carcinoma 10.3 KRT7 KRT14
40 scrotum paget's disease 10.3 MUC1 KRT7
41 ovarian seromucinous carcinoma 10.3 TP53 KRT7
42 aggressive digital papillary adenocarcinoma 10.3 S100B MUC1
43 breast hemangioma 10.3 TP53 KRT7
44 gallbladder signet ring cell adenocarcinoma 10.3 MUC1 KRT7
45 meningeal melanocytoma 10.3 S100B MUC1
46 eccrine papillary adenocarcinoma 10.3 KRT7 KRT14
47 intratubular embryonal carcinoma 10.3 TP53 KRT7
48 cerebral primitive neuroectodermal tumor 10.3 S100B MUC1
49 papillary transitional carcinoma 10.3 TP53 KRT7
50 urinary bladder villous adenoma 10.3 MUC1 KRT7

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to Spiradenoma

Symptoms & Phenotypes for Spiradenoma

MGI Mouse Phenotypes related to Spiradenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 ACTC1 ALPK1 CYLD KRT14 KRT15 KRT7

Drugs & Therapeutics for Spiradenoma

Search Clinical Trials , NIH Clinical Center for Spiradenoma

Genetic Tests for Spiradenoma

Anatomical Context for Spiradenoma

MalaCards organs/tissues related to Spiradenoma:

40
Skin, Smooth Muscle, Breast, Lymph Node, Salivary Gland

Publications for Spiradenoma

Articles related to Spiradenoma:

(show top 50) (show all 358)
# Title Authors PMID Year
1
MYB Translocations in Both Myoepithelial and Ductoglandular Epithelial Cells in Adenoid Cystic Carcinoma: A Histopathologic and Genetic Reappraisal in Six Primary Cutaneous Cases. 61
32732690 2021
2
Metaplastic spiradenocarcinoma: Report of two cases with sarcomatous differentiation. 61
33051901 2021
3
Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review. 61
33522696 2021
4
Malignant Eccrine Adenoma With Sarcomatous (Heterologous) Components: Report of a Rare Skin Adnexal Neoplasm With Literature Review. 61
33532153 2020
5
Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics. 61
33264133 2020
6
Spiradenoma of the breast: a rare diagnostic pitfall in the evaluation of solid-basaloid breast lesions with a dual cell population. 61
33150535 2020
7
Expression of TdT in Myoepithelial Cells: Investigation in Breasts, Sweat Glands, and Salivary Lesions Emphasizing the Never-Documented Immunohistochemical Findings. 61
32362207 2020
8
Brooke-Spiegler Syndrome With Cervical Spine Lesion. 61
33209538 2020
9
[Skin spiradenoma of breast: a clinicopathological analysis of five cases]. 61
32610389 2020
10
Primary Cutaneous Adenomyoepithelioma Ex Spiradenoma With Malignant Histologic Features, Epithelial-Myoepithelial Carcinoma Type: A First Case Report With Molecular Studies. 61
31813296 2020
11
Spiradenoma With Adenoid Cystic Carcinoma-Like Features. 61
31855584 2020
12
Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV. 61
32169099 2020
13
Lipomatous basal cell adenoma (Basal cell lipoadenoma) - Report of the first two cases. 61
31869766 2020
14
Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions. 61
32190505 2020
15
Malignant Eccrine Spiradenoma of the External Auditory Canal: A Case Report and Literature Review. 61
33469512 2020
16
Giant vascular eccrine spiradenoma presenting as a thrombosed varix. 61
31799485 2019
17
Diverse presentations of cutaneous mosaicism occur in CYLD cutaneous syndrome and may result in parent-to-child transmission. 61
31085270 2019
18
An Unusual Nodule on the Auricle: Eccrine Spiradenoma. 61
31119990 2019
19
Magnifying glass on spiradenoma and cylindroma histogenesis and tumorigenesis using systematic transcriptome analysis. 61
31128548 2019
20
Eccrine spiradenoma of the nipple: Case report, differential diagnosis and literature review. 61
30806477 2019
21
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma. 61
31101826 2019
22
Trichoblastic carcinoma arising in trichoepithelioma in Brooke-Spiegler syndrome. 61
30971565 2019
23
Histological findings and pathologic diagnosis of spiradenocarcinoma: A case series and review of the literature. 61
30588645 2019
24
Immunohistochemical Study of Non-Epithelial Cells in Spiradenoma. 61
30918150 2019
25
Malignant transformation of a spiradenoma with blaschkoïd pattern. 61
30455896 2018
26
p63 and smooth muscle actin expression in low-grade spiradenocarcinomas in a case of CYLD cutaneous syndrome. 61
29962004 2018
27
Sonographic appearance of an eccrine spiradenoma: A case report. 61
29271484 2018
28
Eccrine spiradenoma mimicking a painful traumatic neuroma: case report. 61
29076781 2018
29
Myoepithelial-Rich and Infiltrative Giant Vascular Eccrine Spiradenoma: A Unique Presentation of a Rare Adnexal Tumor. 61
28984693 2018
30
Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells. 61
29436004 2018
31
Ultrasonographic Features of Eccrine Spiradenoma. 61
29120034 2018
32
A rare case of Brooke-Spiegler syndrome: integrated surgical treatment of multiple giant eccrine spiradenomas of the head and neck in a young girl. 61
30241087 2018
33
Eccrine spiradenoma: A rare adnexal tumor. 61
30082561 2017
34
Eccrine Spiradenoma of the Scalp. 61
29090205 2017
35
Multiple eccrine spiradenomas in a zosteriform pattern. 61
29469747 2017
36
A Case of Eccrine Spiradenoma: A Rarely Seen Soft Tissue Tumor on the Extensor Surface of Arm. 61
28761313 2017
37
Allergic contact dermatitis to methylisothiazolinone in hair care products: report of a case. 61
29469746 2017
38
MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors. 61
28098399 2017
39
[Malignant transformation of an eccrine spiradenoma]. 61
28277254 2017
40
FDG PET/CT in Malignant Eccrine Spiradenoma. 61
28005641 2017
41
Giant vascular eccrine spiradenoma of the leg: MR imaging findings. 61
27397887 2017
42
Cytopathologic features of an unusual case of multiple eccrine spiradenomas misdiagnosed as a malignant round cell tumor. 61
28182081 2017
43
Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature. 61
27870729 2016
44
Fine needle aspiration cytology of cylindroma of scalp: A case report. 61
27456213 2016
45
The role of DOG1 immunohistochemistry in dermatopathology. 61
27506854 2016
46
Spiradenoma causing longitudinal splitting of the nail. 61
27663150 2016
47
Glomus tumours of the hand: Review of literature. 61
27857505 2016
48
Lymphangiectatic Variant of Eccrine Spiradenoma - A Diagnostic Challenge. 61
28806004 2016
49
Brooke-Spiegler Syndrome and Phenotypic Variants: An Update. 61
26971504 2016
50
Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. 61
26563774 2016

Variations for Spiradenoma

Expression for Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for Spiradenoma

Pathways related to Spiradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 VIM MUC1 KRT7 ACTC1
2 11.39 VIM TP53 MUC1
3
Show member pathways
11.17 VIM KRT7 KRT14

GO Terms for Spiradenoma

Cellular components related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.85 VIM TP53 S100B S100A1 MUC1 KRT7
2 cytosol GO:0005829 9.65 VIM TP53 S100B S100A1 KRT7 KRT15
3 intermediate filament GO:0005882 8.92 VIM KRT7 KRT15 KRT14

Biological processes related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 necroptotic process GO:0070266 9.26 TP53 CYLD
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.16 TP53 MUC1
3 cornification GO:0070268 9.13 KRT7 KRT15 KRT14
4 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 8.62 TP53 MUC1

Molecular functions related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 S100 protein binding GO:0044548 9.16 S100B S100A1
2 structural constituent of cytoskeleton GO:0005200 9.13 VIM KRT15 KRT14
3 keratin filament binding GO:1990254 8.62 VIM KRT14

Sources for Spiradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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