ES
MCID: SPR013
MIFTS: 37

Spiradenoma (ES)

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Spiradenoma

MalaCards integrated aliases for Spiradenoma:

Name: Spiradenoma 12 15
Eccrine Spiradenoma 12 53 73
Benign Eccrine Spiradenoma 12 53
Eccrine Spiradenoma of Skin 12
Eccrine Spiradenoma, Benign 53
Es 53

Classifications:



External Ids:

Disease Ontology 12 DOID:5444
NCIt 50 C4170
SNOMED-CT 68 4977000
UMLS 73 C0334347

Summaries for Spiradenoma

MalaCards based summary : Spiradenoma, also known as eccrine spiradenoma, is related to malignant spiradenoma and brooke-spiegler syndrome. An important gene associated with Spiradenoma is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Abraxane and Abstral have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and kidney, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 76 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

Related Diseases for Spiradenoma

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 323)
# Related Disease Score Top Affiliating Genes
1 malignant spiradenoma 34.0 KRT7 TP53
2 brooke-spiegler syndrome 32.6 CYLD KRT14 KRT7
3 syringoma 30.3 S100B VIM
4 hidradenoma 30.1 KRT7 VIM
5 mixed cell type cancer 30.0 KRT7 TP53
6 epithelioid sarcoma 29.8 KRT7 VIM
7 ependymoma 29.7 S100B VIM
8 carcinosarcoma 29.7 ACTC1 KRT7 TP53 VIM
9 glomus tumor 29.6 ACTC1 TP53 VIM
10 basal cell carcinoma 29.6 CYLD KRT14 KRT7 TP53
11 teratoma 29.4 ACTC1 KRT7 TP53
12 adenoid cystic carcinoma 28.8 ACTC1 CYLD KRT14 KRT7 S100B TP53
13 breast malignant eccrine spiradenoma 12.3
14 benign eccrine breast spiradenoma 12.1
15 adnexal spiradenoma/cylindroma of a sweat gland 12.1
16 ewing sarcoma 11.6
17 continuous spike-wave during slow sleep syndrome 11.3
18 cylindromatosis, familial 11.2
19 diabetic mastopathy 11.1
20 eisenmenger syndrome 11.1
21 ichthyosis prematurity syndrome 10.5
22 anus basaloid carcinoma 10.2 CYLD KRT7
23 sarcoma 10.2
24 status epilepticus 10.2
25 perineurioma 10.1 S100B VIM
26 hydromyelia 10.1 S100B VIM
27 bednar tumor 10.1 S100B VIM
28 primary hepatic neuroendocrine carcinoma 10.1 S100B VIM
29 sarcoma, synovial 10.1 KRT7 VIM
30 oncocytoma 10.1 KRT7 VIM
31 craniopharyngioma 10.1 KRT14 KRT7
32 syringocystadenoma papilliferum 10.1 S100B VIM
33 fibrous meningioma 10.1 S100B VIM
34 chordoid meningioma 10.1 S100B VIM
35 eccrine porocarcinoma 10.1 S100B VIM
36 myxopapillary ependymoma 10.1 S100B VIM
37 juvenile xanthogranuloma 10.1 S100B VIM
38 benign breast adenomyoepithelioma 10.1 KRT14 KRT7
39 breast adenomyoepithelioma 10.1 KRT14 KRT7
40 pleomorphic liposarcoma 10.1 S100B VIM
41 oncocytic breast carcinoma 10.1 KRT14 KRT7
42 amelanotic melanoma 10.1 S100B VIM
43 secretory meningioma 10.1 KRT7 VIM
44 large cell acanthoma 10.1 KRT14 KRT7
45 anaplastic ependymoma 10.1 S100B VIM
46 adenoid squamous cell carcinoma 10.1 KRT7 VIM
47 nodular hidradenoma 10.1 KRT7 VIM
48 papillary adenoma 10.1 KRT7 VIM
49 bile duct adenoma 10.1 KRT7 VIM
50 odontogenic myxoma 10.1 S100B VIM

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to Spiradenoma

Symptoms & Phenotypes for Spiradenoma

MGI Mouse Phenotypes related to Spiradenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.43 ACTC1 CYLD KRT14 KRT7 TP53 VIM
2 homeostasis/metabolism MP:0005376 9.17 ACTC1 CYLD KRT14 KRT7 S100B TP53

Drugs & Therapeutics for Spiradenoma

FDA approved drugs:

(show top 50) (show all 250)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Abraxane 18 49 PACLITAXEL Celgene October 2012
2
Abstral 18 FENTANYL (citrate) ProStrakan January 2011
3
Actiq 18 FENTANYL (citrate) Anesta Corporation November 1998
4
Adcetris 18 49 BRENTUXIMAB VEDOTIN Seattle Genetics August 2011
5
Afinitor 18 49 EVEROLIMUS Novartis March 2009
6
Akynzeo 18 49 NETUPITANT AND PALONOSETRON (hydrochloride) Helsinn October 2014
7
Alimta 18 49 PEMETREXED (also Pemetrexed Disodium) Eli Lilly February 2004
8
Aloxi 18 49 PALONOSETRON (hydrochloride) MGI Pharma, Helsinn Healthcare August 2003
9
Anexsia 18 ACETAMINOPHEN; HYDROCODONE BITARTRATE Mallinckrodt Group August 1996
10
Anzemet 18 DOLASETRON MESYLATE Hoechst Marion Roussel February 1998
11
Aredia 18 49 PAMIDRONATE DISODIUM Chiron August 1996
12
Arimidex 18 49 ANASTROZOLE AstraZeneca January 1996
13
Aromasin Tablets 18 49 EXEMESTANE Pharmacia & Upjohn October 21. 1999
14
Arranon 18 49 NELARABINE GlaxoSmithKline October 2005
15
Arzerra 18 49 OFATUMUMAB GlaxoSmithKline October 2009
16
Avastin 18 49 BEVACIZUMAB Genentech July 2009
17
Beleodaq 18 49 BELINOSTAT Spectrum Pharmaceuticals July 2014
18
Bexxar 18 49 TOSITUMOMAB; IODINE I 131 TOSITUMOMAB Corixa June 2003
19
Blincyto 18 49 BLINATUMOMAB Amgen December 2014
20
Bosulif 18 49 BOSUTINIB MONOHYDRATE Pfizer September 2012
21
Bromfenac 18 BROMFENAC SODIUM Duract, Wyeth-Ayerst Laboratories July 1997
22
Busulfex 18 49 BUSULFAN Orphan Medical February 1999
23
Campath 18 49 ALEMTUZUMAB Berlex Laboratories May 2001
24
Campostar 18 49 IRINOTECAN HYDROCHLORIDE Pharmacia & Upjohn June 1996
25
CEA-Scan 18 Immunomedics April 1996
26
Cervarix 18 49 Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant GlaxoSmithKline October 2009
27
Clolar 18 49 CLOFARABINE Genzyme December, 2004
28
Cometriq 18 49 CABOZANTINIB S-MALATE Exelixis November 2012
29
Cyramza 18 49 RAMUCIRUMAB Eli Lilly April 2014
30
Degarelix 18 49 degarelix Ferring Pharmaceuticals December of 2008
31
Doxil 18 49 DOXORUBICIN HYDROCHLORIDE Alza June 1999
32
Eligard 18 49 LEUPROLIDE ACETATE Atrix Laboratories January 2002
33
Elitek 18 49 RASBURICASE sanofi-aventis October 2009
34
Ellence 18 49 EPIRUBICIN HYDROCHLORIDE Pharmacia & Upjohn September 1999
35
Elliotts B Solution 18 CALCIUM CHLORIDE; DEXTROSE; MAGNESIUM SULFATE; POTASSIUM CHLORIDE; SODIUM BICARBONATE; SODIUM CHLORIDE; SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE Orphan Medical October 1996
36
Eloxatin 18 49 OXALIPLATIN Sanofi-aventis August 2002
37
Emend 18 49 APREPITANT FOSAPREPITANT DIMEGLUMINE Merck March 2003
38
Erbitux 18 49 CETUXIMAB Imclone, Bristol-Myers Squibb February 2004
39
Erivedge 18 49 VISMODEGIB Genentech January 2012
40
Erwinaze 18 49 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
41
Ethyol 18 AMIFOSTINE Alza December 8, 1995
42
Eulexin 18 FLUTAMIDE Schering-Plough June 1996
43
Evista 18 49 RALOXIFENE HYDROCHLORIDE Eli Lilly September 2007
44
Farydak 18 49 PANOBINOSTAT LACTATE Novartis February 2015
45
Faslodex 18 49 FULVESTRANT AstraZeneca April 2002
46
Femara 18 49 LETROZOLE Novartis January 2001
47
Feridex I.V. 18 FERUMOXIDES Advanced Magnetics February 1996
48
Folotyn 18 49 PRALATREXATE Allos Therapeutics September 2009
49
Fusilev 18 LEVOLEUCOVORIN CALCIUM Spectrum Pharmaceuticals March of 2008
50
Gardasil 18 49 quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine Merck June 2006

Search Clinical Trials , NIH Clinical Center for Spiradenoma

Genetic Tests for Spiradenoma

Anatomical Context for Spiradenoma

MalaCards organs/tissues related to Spiradenoma:

41
Skin, Lung, Kidney, Liver, Heart, Ovary, Thyroid

Publications for Spiradenoma

Articles related to Spiradenoma:

(show top 50) (show all 175)
# Title Authors Year
1
Malignant transformation of a spiradenoma with blaschkoïd pattern. ( 30455896 )
2018
2
FDG PET/CT in Malignant Eccrine Spiradenoma. ( 28005641 )
2017
3
Sonographic appearance of an eccrine spiradenoma: A case report. ( 29271484 )
2017
4
Myoepithelial-Rich and Infiltrative Giant Vascular Eccrine Spiradenoma: A Unique Presentation of a Rare Adnexal Tumor. ( 28984693 )
2017
5
A Case of Eccrine Spiradenoma: A Rarely Seen Soft Tissue Tumor on the Extensor Surface of Arm. ( 28761313 )
2017
6
Eccrine Spiradenoma of the Scalp. ( 29090205 )
2017
7
Spiradenoma ( 28846324 )
2017
8
Eccrine spiradenoma mimicking a painful traumatic neuroma: case report. ( 29076781 )
2017
9
Ultrasonographic Features of Eccrine Spiradenoma. ( 29120034 )
2017
10
Eccrine spiradenoma: A rare adnexal tumor. ( 30082561 )
2017
11
Lymphangiectatic Variant of Eccrine Spiradenoma - A Diagnostic Challenge. ( 28806004 )
2016
12
A rare case of eccrine spiradenoma-treatment and management. ( 27069311 )
2016
13
Spiradenoma causing longitudinal splitting of the nail. ( 27663150 )
2016
14
Giant vascular eccrine spiradenoma of the leg: MR imaging findings. ( 27397887 )
2016
15
Giant Vascular Eccrine Spiradenoma. ( 26365030 )
2015
16
Zosteriform spiradenoma with spiradenocarcinoma: A rare entity. ( 26904446 )
2015
17
Sonographic and sonoelastographic findings of a rarely seen soft tissue tumor: eccrine spiradenoma. ( 26576987 )
2015
18
Malignant eccrine spiradenoma of the external ear. ( 26211868 )
2015
19
Inexplicable Co- Existence of Eccrine Spiradenoma and Lichen Planus in an old Case of Basal Cell Carcinoma. ( 25737995 )
2015
20
Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. ( 26563774 )
2015
21
Malignant eccrine breast spiradenoma. A case report and literature review. ( 26318134 )
2015
22
Trichoepithelioma and spiradenoma collision tumor. ( 25942028 )
2015
23
Eccrine Spiradenoma Arising from the Breast Skin. ( 26236527 )
2015
24
Giant eccrine spiradenoma mimicking a malignant tumor. ( 25566913 )
2015
25
Malignant Eccrine Spiradenoma of the Face. ( 26167988 )
2015
26
Spiradenocarcinoma in Preexisting Spiradenoma With a Large In Situ Adenocarcinoma Component. ( 25830720 )
2015
27
A serpentine inside eccrine spiradenoma: a new trichoscopic sign. ( 25878450 )
2015
28
Multiple Segmental Eccrine Spiradenoma with a Zosteriform Pattern: A Case Report and Literature Review. ( 26273161 )
2015
29
Eccrine spiradenoma in knee. ( 25284865 )
2014
30
Tubular Spitz Naevus Mimicking Eccrine Spiradenoma. ( 23756597 )
2014
31
Case of recurrence of spiradenoma in palpebral conjunctiva. ( 24969313 )
2014
32
A malignant eccrine spiradenoma of the scalp. ( 24842352 )
2014
33
Differential diagnosis of eccrine spiradenoma: A case report. ( 25187803 )
2014
34
Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers. ( 25354097 )
2014
35
Fine needle aspiration cytology of eccrine spiradenoma of back: report of a rare case. ( 25328342 )
2014
36
Cystic eccrine spiradenoma of the finger mimicking a ganglion. ( 25289292 )
2014
37
Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. ( 24118397 )
2013
38
Immunohistochemical characterization of non-epithelial cells in spiradenoma. ( 24580131 )
2013
39
Giant vascular eccrine spiradenoma mimicking calcifying epithelioma. ( 23961898 )
2013
40
Neonatal spiradenoma. ( 22747799 )
2013
41
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma and eccrine spiradenoma. ( 24261740 )
2013
42
Malignant spiradenoma/cylindroma of the vulva. ( 23147883 )
2012
43
Dermatoscopic pattern of a spiradenoma. ( 23785623 )
2012
44
Painful eccrine spiradenoma containing nerve fibers: a case report. ( 22777362 )
2012
45
Eccrine spiradenoma arising in the breast misdiagnosed as an epidermal inclusion cyst. ( 21430945 )
2011
46
Malignant eccrine spiradenoma: a meta-analysis of reported cases. ( 20851376 )
2011
47
Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression. ( 21598248 )
2011
48
A rare case of giant malignant eccrine spiradenoma. ( 21342314 )
2011
49
Carcinosarcoma ex eccrine spiradenoma of the vulva: report of the first case. ( 21464722 )
2011
50
Differential considerations of skin tumours with florid vascularisation: report of a solitary giant vascular eccrine spiradenoma. ( 22689604 )
2011

Variations for Spiradenoma

Expression for Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for Spiradenoma

Pathways related to Spiradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 ACTC1 KRT7 VIM
2
Show member pathways
10.83 KRT14 KRT7 VIM

GO Terms for Spiradenoma

Cellular components related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 ACTC1 CYLD KRT14 KRT7 S100B TP53
2 intermediate filament GO:0005882 8.8 KRT14 KRT7 VIM

Biological processes related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.13 ACTC1 TP53 VIM
2 muscle filament sliding GO:0030049 8.62 ACTC1 VIM

Molecular functions related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament binding GO:1990254 8.62 KRT14 VIM

Sources for Spiradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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