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ES
MCID: SPR013
MIFTS: 39

Spiradenoma (ES)

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Spiradenoma

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MalaCards integrated aliases for Spiradenoma:

Name: Spiradenoma 11 14 75
Eccrine Spiradenoma 11 19 71
Benign Eccrine Spiradenoma 11 19
Eccrine Spiradenoma of Skin 11
Eccrine Spiradenoma, Benign 19
Es 19

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:5444
NCIt 49 C4170
SNOMED-CT 68 403938001
UMLS 71 C0334347
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Summaries for Spiradenoma

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GARD: 19 A benign epithelial neoplasm with eccrine or apocrine differentiation, arising from the sweat glands. It usually presents as a solitary, well circumscribed, firm nodule in the face and upper trunk. It is characterized by the presence of basaloid cells forming nodules in the dermis. Cases of carcinoma arising from long standing spiradenomas have been reported.

MalaCards based summary: Spiradenoma, also known as eccrine spiradenoma, is related to malignant spiradenoma and brooke-spiegler syndrome. An important gene associated with Spiradenoma is CYLD (CYLD Lysine 63 Deubiquitinase). Affiliated tissues include skin, salivary gland and smooth muscle, and related phenotype is digestive/alimentary.

Wikipedia: 75 Spiradenomas (SA) are rare, benign cutaneous adnexal tumors that may progress to become their malignant... more...
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Related Diseases for Spiradenoma

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Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
# Related Disease Score Top Affiliating Genes
1 malignant spiradenoma 32.0 PIP KRT7 KRT5 CYLD CEACAM5
2 brooke-spiegler syndrome 30.9 TRAIP TMEM207 NFIB KRT7 CYLD ALPK1
3 adenoid cystic carcinoma 30.8 NTRK3 NFIB KRT7 CYLD
4 skin benign neoplasm 30.5 PIP KRT7 KRT5 CYLD
5 syringoma 30.4 PIP KRT7 CEACAM5
6 eccrine acrospiroma 30.1 PIP KRT7 KRT5 CEACAM5
7 breast metaplastic carcinoma 30.1 KRT7 KRT5
8 basal cell carcinoma 29.9 PIP KRT7 KRT5 KRT15 CYLD
9 apocrine adenoma 29.8 PIP KRT7 CEACAM5
10 adenocarcinoma in situ 29.8 KRT7 CEACAM5
11 mixed cell type cancer 29.8 KRT7 KRT5 CEACAM5
12 hidradenoma 29.7 PIP KRT7 KRT5 KRT15 CEACAM5
13 spindle cell sarcoma 29.7 SOX10 NTRK3 KRT7
14 sweat gland benign neoplasm 29.7 SOX10 PIP KRT7 KRT5 CYLD CEACAM5
15 myoepithelial carcinoma 29.6 SOX10 NFIB KRT7 KRT5
16 apocrine adenocarcinoma 29.5 PIP KRT7 KRT5 CEACAM5
17 sweat gland cancer 29.5 PIP KRT7 KRT5 KRT15 CEACAM5
18 salivary gland adenoid cystic carcinoma 29.5 SOX10 PIP NTRK3 NFIB KRT7 KRT5
19 syringocystadenoma papilliferum 29.0 SOX10 PIP KRT7 KRT5 KRT15 CEACAM5
20 epithelial-myoepithelial carcinoma 29.0 SOX10 PIP NTRK3 NFIB KRT7 KRT5
21 breast malignant eccrine spiradenoma 11.3
22 benign eccrine breast spiradenoma 11.1
23 adnexal spiradenoma/cylindroma of a sweat gland 11.1
24 rare tumor 10.4
25 epidermal appendage tumor 10.3 KRT15 CYLD
26 lung adenoid cystic carcinoma 10.3 NFIB KRT7
27 cervical adenoid cystic carcinoma 10.3 NFIB KRT7
28 anal canal paget's disease 10.3 PIP KRT7
29 anal gland adenocarcinoma 10.3 PIP KRT7
30 bartholin's gland adenocarcinoma 10.3 PIP KRT7
31 basosquamous carcinoma 10.3 KRT7 KRT15
32 anus adenocarcinoma 10.3 PIP KRT7
33 oncocytic breast carcinoma 10.3 PIP KRT7
34 anal canal adenocarcinoma 10.3 PIP KRT7
35 gastric signet ring cell adenocarcinoma 10.3 PIP KRT7
36 eyelid carcinoma 10.3 PIP KRT7
37 meibomian cyst 10.3 PIP KRT7
38 posttransplant acute limbic encephalitis 10.3
39 laryngeal adenoid cystic carcinoma 10.3 KRT7 KRT5
40 inverted transitional papilloma 10.3 KRT7 KRT5
41 erysipeloid 10.3 PIP KRT7
42 microinvasive cervical squamous cell carcinoma 10.3 KRT7 KRT5
43 subareolar duct papillomatosis 10.3 KRT7 KRT5
44 prostatic urethral cancer 10.3 KRT7 KRT5
45 nipple benign neoplasm 10.3 KRT7 KRT5
46 bartholin's gland disease 10.3 PIP KRT7
47 vulvar sebaceous carcinoma 10.3 KRT7 KRT5
48 rete testis neoplasm 10.3 KRT7 KRT5
49 adenosquamous gallbladder carcinoma 10.3 KRT7 KRT5
50 bilateral hypoactive labyrinth 10.3 SOX10 KRT7

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to Spiradenoma
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Symptoms & Phenotypes for Spiradenoma

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MGI Mouse Phenotypes related to Spiradenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 CEACAM5 CYLD KRT15 KRT5 NFIB PIP
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Drugs & Therapeutics for Spiradenoma

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Search Clinical Trials, NIH Clinical Center for Spiradenoma

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Genetic Tests for Spiradenoma

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Anatomical Context for Spiradenoma

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Organs/tissues related to Spiradenoma:

MalaCards : Skin, Salivary Gland, Smooth Muscle, Breast, Lymph Node, Bone
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Publications for Spiradenoma

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Articles related to Spiradenoma:

(show top 50) (show all 376)
# Title Authors PMID Year
1
Tender Cutaneous Neoplasms: Case Reports of Patients With a Symptomatic Dermatofibroma and a New Acrostic for Painful Tumors of the Skin. 62
36321023 2022
2
Cutaneous ultrasound: key diagnostic tool for the relapse of a single eccrine spiradenoma. 62
34637118 2022
3
Fine needle aspiration cytopathology of eccrine spiradenoma. 62
35672250 2022
4
Intravenous Lobular Capillary Hemangioma: A Case Report and Proposal for New Cutaneous Tender Tumor Differential Diagnosis Acronym. 62
36120217 2022
5
A rare histopathological spiradenocylindroma: a case report. 62
35857041 2022
6
Benign eccrine spiradenoma imitating a nerve sheath tumor: illustrative case. 62
35733843 2022
7
Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review. 62
35717180 2022
8
Reflectance confocal microscopy of spiradenoma. 62
35662854 2022
9
Giant vascular eccrine spiradenoma; A rare entity with review of literature. 62
35075012 2022
10
Efficacy of Triamcinolone Acetonide Injection in a Case of Giant Spiradenoma. 62
35791436 2022
11
Eccrine spiradenoma mimicking adenoid cystic carcinoma cytologically (Two case reports and literature review). 62
34525270 2022
12
Acquired nasolacrimal duct obstruction: clinical and histological findings of 275 cases. 62
34986808 2022
13
Recent Advances on Immunohistochemistry and Molecular Biology for the Diagnosis of Adnexal Sweat Gland Tumors. 62
35158743 2022
14
Giant (pseudo) vascular spiradenoma: a case report of an extremely rare entity with the immuno-histological demonstration of the coexistence of vascular and pseudo-vascular components. 62
33890732 2021
15
Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review. 62
33522696 2021
16
Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics. 62
33264133 2021
17
Spiradenoma of the breast: a rare diagnostic pitfall in the evaluation of solid-basaloid breast lesions with a dual cell population. 62
33150535 2021
18
MYB Translocations in Both Myoepithelial and Ductoglandular Epithelial Cells in Adenoid Cystic Carcinoma: A Histopathologic and Genetic Reappraisal in Six Primary Cutaneous Cases. 62
32732690 2021
19
A rare case of malignant eccrine spiradenoma mimicking carcinosarcoma. 62
33851645 2021
20
Giant vascular eccrine spiradenoma: the first case in the scrotum and review of the literature author. 62
33941210 2021
21
Ultrasonographic features of eccrine spiradenoma: A case report. 62
33832160 2021
22
Metaplastic spiradenocarcinoma: Report of two cases with sarcomatous differentiation. 62
33051901 2021
23
Eccrine spiradenoma: a rare adnexal tumour with atypical presentation: A case report. 62
33819250 2021
24
Malignant Eccrine Adenoma With Sarcomatous (Heterologous) Components: Report of a Rare Skin Adnexal Neoplasm With Literature Review. 62
33532153 2020
25
Expression of TdT in Myoepithelial Cells: Investigation in Breasts, Sweat Glands, and Salivary Lesions Emphasizing the Never-Documented Immunohistochemical Findings. 62
32362207 2020
26
Brooke-Spiegler Syndrome With Cervical Spine Lesion. 62
33209538 2020
27
[Skin spiradenoma of breast: a clinicopathological analysis of five cases]. 62
32610389 2020
28
Primary Cutaneous Adenomyoepithelioma Ex Spiradenoma With Malignant Histologic Features, Epithelial-Myoepithelial Carcinoma Type: A First Case Report With Molecular Studies. 62
31813296 2020
29
Spiradenoma With Adenoid Cystic Carcinoma-Like Features. 62
31855584 2020
30
Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV. 62
32169099 2020
31
Lipomatous basal cell adenoma (Basal cell lipoadenoma) - Report of the first two cases. 62
31869766 2020
32
Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions. 62
32190505 2020
33
Malignant Eccrine Spiradenoma of the External Auditory Canal: A Case Report and Literature Review. 62
33469512 2020
34
Diverse presentations of cutaneous mosaicism occur in CYLD cutaneous syndrome and may result in parent-to-child transmission. 62
31085270 2019
35
Giant vascular eccrine spiradenoma presenting as a thrombosed varix. 62
31799485 2019
36
An Unusual Nodule on the Auricle: Eccrine Spiradenoma. 62
31119990 2019
37
Eccrine spiradenoma of the nipple: Case report, differential diagnosis and literature review. 62
30806477 2019
38
Magnifying glass on spiradenoma and cylindroma histogenesis and tumorigenesis using systematic transcriptome analysis. 62
31128548 2019
39
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma. 62
31101826 2019
40
Trichoblastic carcinoma arising in trichoepithelioma in Brooke-Spiegler syndrome. 62
30971565 2019
41
Histological findings and pathologic diagnosis of spiradenocarcinoma: A case series and review of the literature. 62
30588645 2019
42
Immunohistochemical Study of Non-Epithelial Cells in Spiradenoma. 62
30918150 2019
43
Malignant transformation of a spiradenoma with blaschkoïd pattern. 62
30455896 2018
44
p63 and smooth muscle actin expression in low-grade spiradenocarcinomas in a case of CYLD cutaneous syndrome. 62
29962004 2018
45
Eccrine spiradenoma mimicking a painful traumatic neuroma: case report. 62
29076781 2018
46
Sonographic appearance of an eccrine spiradenoma: A case report. 62
29271484 2018
47
Myoepithelial-Rich and Infiltrative Giant Vascular Eccrine Spiradenoma: A Unique Presentation of a Rare Adnexal Tumor. 62
28984693 2018
48
Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells. 62
29436004 2018
49
Ultrasonographic Features of Eccrine Spiradenoma. 62
29120034 2018
50
A rare case of Brooke-Spiegler syndrome: integrated surgical treatment of multiple giant eccrine spiradenomas of the head and neck in a young girl. 62
30241087 2018
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Variations for Spiradenoma

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Cosmic variations for Spiradenoma:

8 (show top 50) (show all 2495)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122741017 TP53 skin,trunk,carcinoma,NS c.440G>A p.G147E 17:7673784-7673784 4
2 COSM144653327 TP53 skin,face,carcinoma,NS c.*131C>T p.? 17:7670685-7670685 4
3 COSM112254631 TP53 skin,face,carcinoma,NS c.586C>T p.R196* 17:7674945-7674945 4
4 COSM143371865 TP53 skin,face,carcinoma,NS c.469C>T p.R157* 17:7674945-7674945 4
5 COSM93183824 TP53 skin,face,carcinoma,NS c.680C>T p.S227F 17:7674283-7674283 4
6 COSM121875437 TP53 skin,face,carcinoma,NS c.178C>T p.Q60* 17:7674957-7674957 4
7 COSM143388508 TP53 skin,face,carcinoma,NS c.629G>C p.R210T 17:7674217-7674217 4
8 COSM111758868 TP53 skin,face,carcinoma,NS c.742C>T p.R248W 17:7674221-7674221 4
9 COSM142570304 TP53 skin,face,carcinoma,NS c.715C>T p.P239S 17:7673788-7673788 4
10 COSM142560384 TP53 skin,face,carcinoma,NS c.616G>T p.G206C 17:7674230-7674230 4
11 COSM142742951 TP53 skin,face,carcinoma,NS c.315G>A p.Q105= 17:7675180-7675180 4
12 COSM105639284 TP53 skin,face,carcinoma,NS c.712T>A p.C238S 17:7674251-7674251 4
13 COSM112253879 TP53 skin,face,carcinoma,NS c.742C>T p.R248W 17:7674221-7674221 4
14 COSM121878773 TP53 skin,face,carcinoma,NS c.241C>T p.R81* 17:7674894-7674894 4
15 COSM111776406 TP53 skin,face,carcinoma,NS c.993+1G>A p.? 17:7673534-7673534 4
16 COSM142837551 TP53 skin,face,carcinoma,NS c.742C>T p.R248W 17:7674221-7674221 4
17 COSM122742188 TP53 skin,face,carcinoma,NS c.58C>T p.P20S 17:7675158-7675158 4
18 COSM122735020 TP53 skin,face,carcinoma,NS c.190C>T p.R64* 17:7674945-7674945 4
19 COSM88272290 TP53 skin,trunk,carcinoma,NS c.480G>C p.M160I 17:7675132-7675132 4
20 COSM144028845 TP53 skin,face,carcinoma,NS c.679T>A p.C227S 17:7674251-7674251 4
21 COSM144021997 TP53 skin,face,carcinoma,NS c.421C>T p.P141S 17:7675158-7675158 4
22 COSM144015364 TP53 skin,face,carcinoma,NS c.604C>T p.R202* 17:7674894-7674894 4
23 COSM143944858 TP53 skin,trunk,carcinoma,NS c.109C>T p.R37* 17:7674945-7674945 4
24 COSM143156879 TP53 skin,trunk,carcinoma,NS c.245C>T p.S82F 17:7674241-7674241 4
25 COSM144316210 TP53 skin,trunk,carcinoma,NS c.716C>T p.P239L 17:7673787-7673787 4
26 COSM121877621 TP53 skin,face,carcinoma,NS c.190C>T p.R64* 17:7674945-7674945 4
27 COSM93201188 TP53 skin,face,carcinoma,NS c.993+1G>A p.? 17:7673534-7673534 4
28 COSM106455733 TP53 skin,trunk,carcinoma,NS c.853G>C p.E285Q 17:7673767-7673767 4
29 COSM144658487 TP53 skin,face,carcinoma,NS c.143C>A p.P48Q 17:7676109-7676109 4
30 COSM142639459 TP53 skin,face,carcinoma,NS c.597T>A p.C199* 17:7674249-7674249 4
31 COSM105620390 TP53 skin,face,carcinoma,NS c.733G>T p.G245C 17:7674230-7674230 4
32 COSM144014436 TP53 skin,face,carcinoma,NS c.553C>T p.R185* 17:7674945-7674945 4
33 COSM112253194 TP53 skin,face,carcinoma,NS c.833C>G p.P278R 17:7673787-7673787 4
34 COSM112263720 TP53 skin,face,carcinoma,NS c.832C>T p.P278S 17:7673788-7673788 4
35 COSM122272676 TP53 skin,face,carcinoma,NS c.190C>T p.R64* 17:7674945-7674945 4
36 COSM143157606 TP53 skin,trunk,carcinoma,NS c.109C>T p.R37* 17:7674945-7674945 4
37 COSM144310437 TP53 skin,trunk,carcinoma,NS c.727C>T p.R243W 17:7673776-7673776 4
38 COSM93239210 TP53 skin,face,carcinoma,NS c.706T>C p.Y236H 17:7674257-7674257 4
39 COSM144651436 TP53 skin,face,carcinoma,NS c.625C>T p.R209W 17:7674221-7674221 4
40 COSM105620642 TP53 skin,face,carcinoma,NS c.742C>T p.R248W 17:7674221-7674221 4
41 COSM144013959 TP53 skin,face,carcinoma,NS c.502C>T p.H168Y 17:7675077-7675077 4
42 COSM143949062 TP53 skin,face,carcinoma,NS c.263A>C p.N88T 17:7674223-7674223 4
43 COSM112571322 TP53 skin,trunk,carcinoma,NS c.480G>C p.M160I 17:7675132-7675132 4
44 COSM112253674 TP53 skin,trunk,carcinoma,NS c.722C>T p.S241F 17:7674241-7674241 4
45 COSM121876459 TP53 skin,face,carcinoma,NS c.346C>T p.R116W 17:7674221-7674221 4
46 COSM111775215 TP53 skin,face,carcinoma,NS c.746G>C p.R249T 17:7674217-7674217 4
47 COSM111765498 TP53 skin,face,carcinoma,NS c.854A>T p.E285V 17:7673766-7673766 4
48 COSM142845131 TP53 skin,trunk,carcinoma,NS c.832C>T p.P278S 17:7673788-7673788 4
49 COSM142838765 TP53 skin,face,carcinoma,NS c.*131C>T p.? 17:7670685-7670685 4
50 COSM93191278 TP53 skin,face,carcinoma,NS c.517G>A p.V173M 17:7675095-7675095 4
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Expression for Spiradenoma

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Search GEO for disease gene expression data for Spiradenoma.
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Pathways for Spiradenoma

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GO Terms for Spiradenoma

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Biological processes related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.43 TRAIP CYLD CD200
2 intermediate filament organization GO:0045109 9.1 KRT7 KRT5 KRT15
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Sources for Spiradenoma

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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