MCID: SPR013
MIFTS: 39

Spiradenoma

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Spiradenoma

MalaCards integrated aliases for Spiradenoma:

Name: Spiradenoma 12 15
Eccrine Spiradenoma 12 53 73
Benign Eccrine Spiradenoma 12 53
Eccrine Spiradenoma of Skin 12
Eccrine Spiradenoma, Benign 53
Es 53

Classifications:



External Ids:

Disease Ontology 12 DOID:5444
NCIt 50 C4170
SNOMED-CT 68 403938001 4977000
UMLS 73 C0334347

Summaries for Spiradenoma

MalaCards based summary : Spiradenoma, also known as eccrine spiradenoma, is related to malignant spiradenoma and brooke-spiegler syndrome. An important gene associated with Spiradenoma is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Cytoskeletal Signaling and Interleukin-4 and 13 signaling. The drugs Erbitux and Evista have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells.

Wikipedia : 76 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

Related Diseases for Spiradenoma

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 329)
# Related Disease Score Top Affiliating Genes
1 malignant spiradenoma 34.1 KRT7 TP53
2 brooke-spiegler syndrome 32.5 CYLD KRT14 KRT7
3 mixed cell type cancer 30.0 KRT7 TP53
4 glomus tumor 29.9 TP53 VIM
5 syringoma 29.2 MUC1 S100B VIM
6 hidradenoma 28.9 KRT7 MUC1 VIM
7 epithelioid sarcoma 28.8 KRT7 MUC1 VIM
8 ependymoma 28.6 MUC1 S100B VIM
9 basal cell carcinoma 28.6 CYLD KRT14 KRT7 TP53
10 adenoid cystic carcinoma 25.7 CYLD KRT14 KRT7 MUC1 S100B TP53
11 benign eccrine breast spiradenoma 11.9
12 breast malignant eccrine spiradenoma 11.9
13 adnexal spiradenoma/cylindroma of a sweat gland 11.9
14 ewing sarcoma 11.4
15 cylindromatosis, familial 11.1
16 diabetic mastopathy 10.9
17 eisenmenger syndrome 10.9
18 anus basaloid carcinoma 10.6 CYLD KRT7
19 hydromyelia 10.5 S100B VIM
20 bednar tumor 10.5 S100B VIM
21 primary hepatic neuroendocrine carcinoma 10.5 S100B VIM
22 melanotic neuroectodermal tumor 10.5 S100B VIM
23 angiocentric glioma 10.5 S100B VIM
24 juvenile xanthogranuloma 10.4 S100B VIM
25 benign breast adenomyoepithelioma 10.4 KRT14 KRT7
26 adenoid squamous cell carcinoma 10.4 KRT7 VIM
27 cutaneous fibrous histiocytoma 10.4 S100B VIM
28 epidermal appendage tumor 10.4 CYLD TP53
29 large cell acanthoma 10.4 KRT14 KRT7
30 oncocytic breast carcinoma 10.4 KRT14 KRT7
31 papillary adenoma 10.4 KRT7 VIM
32 benign metastasizing leiomyoma 10.4 KRT7 VIM
33 odontogenic myxoma 10.4 S100B VIM
34 granular cell tumor 10.4 S100B VIM
35 medulloepithelioma 10.4 KRT7 VIM
36 metanephric adenoma 10.4 KRT7 VIM
37 adenomatoid tumor 10.4 KRT7 VIM
38 breast adenomyoepithelioma 10.4 KRT14 KRT7
39 breast myoepithelial neoplasm 10.4 KRT14 KRT7
40 malignant giant cell tumor 10.4 S100B TP53
41 ameloblastic carcinoma 10.3 KRT14 VIM
42 microglandular adenosis 10.3 S100B TP53
43 endodermal sinus tumor 10.3 KRT7 VIM
44 osteochondroma 10.3 S100B VIM
45 odontoma 10.3 KRT14 VIM
46 female reproductive endometrioid cancer 10.3 KRT7 TP53
47 eccrine sweat gland neoplasm 10.3 KRT7 TP53
48 pleuropulmonary blastoma 10.3 S100B TP53
49 bladder carcinoma in situ 10.3 KRT7 TP53
50 papillary serous adenocarcinoma 10.3 KRT7 TP53

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to Spiradenoma

Symptoms & Phenotypes for Spiradenoma

Drugs & Therapeutics for Spiradenoma

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Erbitux 18 49 CETUXIMAB Imclone, Bristol-Myers Squibb February 2004
2
Evista 18 49 RALOXIFENE HYDROCHLORIDE Eli Lilly September 2007
3
Istodax 18 49 ROMIDEPSIN Gloucester Pharmaceuticals November 2009
4
Treanda 18 49 BENDAMUSTINE HYDROCHLORIDE Cephalon October 2008

Search Clinical Trials , NIH Clinical Center for Spiradenoma

Genetic Tests for Spiradenoma

Anatomical Context for Spiradenoma

MalaCards organs/tissues related to Spiradenoma:

41
Skin, T Cells, B Cells, Endothelial, Testes, Colon, Bone

Publications for Spiradenoma

Articles related to Spiradenoma:

(show top 50) (show all 173)
# Title Authors Year
1
FDG PET/CT in Malignant Eccrine Spiradenoma. ( 28005641 )
2017
2
Sonographic appearance of an eccrine spiradenoma: A case report. ( 29271484 )
2017
3
Myoepithelial-Rich and Infiltrative Giant Vascular Eccrine Spiradenoma: A Unique Presentation of a Rare Adnexal Tumor. ( 28984693 )
2017
4
A Case of Eccrine Spiradenoma: A Rarely Seen Soft Tissue Tumor on the Extensor Surface of Arm. ( 28761313 )
2017
5
Eccrine Spiradenoma of the Scalp. ( 29090205 )
2017
6
Spiradenoma ( 28846324 )
2017
7
Eccrine spiradenoma mimicking a painful traumatic neuroma: case report. ( 29076781 )
2017
8
Ultrasonographic Features of Eccrine Spiradenoma. ( 29120034 )
2017
9
Lymphangiectatic Variant of Eccrine Spiradenoma - A Diagnostic Challenge. ( 28806004 )
2016
10
A rare case of eccrine spiradenoma-treatment and management. ( 27069311 )
2016
11
Spiradenoma causing longitudinal splitting of the nail. ( 27663150 )
2016
12
Giant vascular eccrine spiradenoma of the leg: MR imaging findings. ( 27397887 )
2016
13
Distinctive immunostaining of claudin-4 in spiradenomas. ( 26616722 )
2016
14
Giant Vascular Eccrine Spiradenoma. ( 26365030 )
2015
15
Zosteriform spiradenoma with spiradenocarcinoma: A rare entity. ( 26904446 )
2015
16
Sonographic and sonoelastographic findings of a rarely seen soft tissue tumor: eccrine spiradenoma. ( 26576987 )
2015
17
Malignant eccrine spiradenoma of the external ear. ( 26211868 )
2015
18
Inexplicable Co- Existence of Eccrine Spiradenoma and Lichen Planus in an old Case of Basal Cell Carcinoma. ( 25737995 )
2015
19
Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. ( 26563774 )
2015
20
Malignant eccrine breast spiradenoma. A case report and literature review. ( 26318134 )
2015
21
Trichoepithelioma and spiradenoma collision tumor. ( 25942028 )
2015
22
Eccrine Spiradenoma Arising from the Breast Skin. ( 26236527 )
2015
23
Giant eccrine spiradenoma mimicking a malignant tumor. ( 25566913 )
2015
24
Malignant Eccrine Spiradenoma of the Face. ( 26167988 )
2015
25
Spiradenocarcinoma in Preexisting Spiradenoma With a Large In Situ Adenocarcinoma Component. ( 25830720 )
2015
26
A serpentine inside eccrine spiradenoma: a new trichoscopic sign. ( 25878450 )
2015
27
Multiple Segmental Eccrine Spiradenoma with a Zosteriform Pattern: A Case Report and Literature Review. ( 26273161 )
2015
28
Eccrine spiradenoma in knee. ( 25284865 )
2014
29
Tubular Spitz Naevus Mimicking Eccrine Spiradenoma. ( 23756597 )
2014
30
Case of recurrence of spiradenoma in palpebral conjunctiva. ( 24969313 )
2014
31
A malignant eccrine spiradenoma of the scalp. ( 24842352 )
2014
32
Differential diagnosis of eccrine spiradenoma: A case report. ( 25187803 )
2014
33
Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers. ( 25354097 )
2014
34
Fine needle aspiration cytology of eccrine spiradenoma of back: report of a rare case. ( 25328342 )
2014
35
Cystic eccrine spiradenoma of the finger mimicking a ganglion. ( 25289292 )
2014
36
Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. ( 24118397 )
2013
37
Immunohistochemical characterization of non-epithelial cells in spiradenoma. ( 24580131 )
2013
38
Giant vascular eccrine spiradenoma mimicking calcifying epithelioma. ( 23961898 )
2013
39
Neonatal spiradenoma. ( 22747799 )
2013
40
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma and eccrine spiradenoma. ( 24261740 )
2013
41
Malignant spiradenoma/cylindroma of the vulva. ( 23147883 )
2012
42
Dermatoscopic pattern of a spiradenoma. ( 23785623 )
2012
43
Painful eccrine spiradenoma containing nerve fibers: a case report. ( 22777362 )
2012
44
Eccrine spiradenoma arising in the breast misdiagnosed as an epidermal inclusion cyst. ( 21430945 )
2011
45
Malignant eccrine spiradenoma: a meta-analysis of reported cases. ( 20851376 )
2011
46
Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression. ( 21598248 )
2011
47
A rare case of giant malignant eccrine spiradenoma. ( 21342314 )
2011
48
Carcinosarcoma ex eccrine spiradenoma of the vulva: report of the first case. ( 21464722 )
2011
49
Differential considerations of skin tumours with florid vascularisation: report of a solitary giant vascular eccrine spiradenoma. ( 22689604 )
2011
50
Alteration of the I^-catenin pathway in spiradenoma. ( 21518380 )
2011

Variations for Spiradenoma

Expression for Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for Spiradenoma

Pathways related to Spiradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 KRT7 MUC1 VIM
2 11.19 MUC1 TP53 VIM
3
Show member pathways
10.83 KRT14 KRT7 VIM

GO Terms for Spiradenoma

Cellular components related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 CYLD KRT14 KRT7 MUC1 S100B TP53
2 intermediate filament GO:0005882 8.8 KRT14 KRT7 VIM

Biological processes related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.16 MUC1 TP53
2 cytokine-mediated signaling pathway GO:0019221 9.13 MUC1 TP53 VIM
3 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.62 MUC1 TP53

Molecular functions related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament binding GO:1990254 8.62 KRT14 VIM

Sources for Spiradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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