ES
MCID: SPR013
MIFTS: 33

Spiradenoma (ES)

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Spiradenoma

MalaCards integrated aliases for Spiradenoma:

Name: Spiradenoma 12 15
Eccrine Spiradenoma 12 54 74
Benign Eccrine Spiradenoma 12 54
Eccrine Spiradenoma of Skin 12
Eccrine Spiradenoma, Benign 54
Es 54

Classifications:



External Ids:

Disease Ontology 12 DOID:5444
NCIt 51 C4170
SNOMED-CT 69 4977000
UMLS 74 C0334347

Summaries for Spiradenoma

MalaCards based summary : Spiradenoma, also known as eccrine spiradenoma, is related to malignant spiradenoma and brooke-spiegler syndrome. An important gene associated with Spiradenoma is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways is Cytoskeletal Signaling. Affiliated tissues include skin, smooth muscle and lymph node.

Wikipedia : 77 Spiradenoma, also spiroma or eccrine spiradenoma, is a cutaneous condition that is typically... more...

Related Diseases for Spiradenoma

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 394)
# Related Disease Score Top Affiliating Genes
1 malignant spiradenoma 34.2 KRT7 TP53
2 brooke-spiegler syndrome 32.6 CYLD KRT14 KRT7
3 syringoma 30.4 MUC1 S100B
4 hidradenoma 30.2 KRT7 MUC1
5 epithelioid sarcoma 30.0 KRT7 MUC1
6 sweat gland cancer 29.9 KRT14 KRT7 TP53
7 basal cell carcinoma 29.9 CYLD KRT7 TP53
8 glomus tumor 29.8 ACTC1 TP53
9 ependymoma 29.7 MUC1 S100B
10 carcinosarcoma 29.5 ACTC1 KRT7 MUC1 TP53
11 teratoma 29.4 ACTC1 KRT7 TP53
12 adenoid cystic carcinoma 28.1 ACTC1 CYLD KRT14 KRT7 MUC1 S100B
13 breast malignant eccrine spiradenoma 12.3
14 benign eccrine breast spiradenoma 12.1
15 adnexal spiradenoma/cylindroma of a sweat gland 12.1
16 ewing sarcoma 11.6
17 eisenmenger syndrome 11.5
18 continuous spike-wave during slow sleep syndrome 11.3
19 cylindromatosis, familial 11.2
20 diabetic mastopathy 11.1
21 ichthyosis prematurity syndrome 10.5
22 anus basaloid carcinoma 10.3 CYLD KRT7
23 pilomatrixoma 10.2 MUC1 S100B
24 meningioma, radiation-induced 10.2 MUC1 S100B
25 cellular schwannoma 10.2 S100B TP53
26 ganglioglioma 10.2 S100B TP53
27 hemangioblastoma 10.2 MUC1 S100B
28 status epilepticus 10.2
29 neurofibroma 10.2 MUC1 S100B
30 perineurioma 10.2 MUC1 S100B
31 ovarian cancer 1 10.2 KRT7 TP53
32 sarcoma, synovial 10.2 KRT7 MUC1
33 oncocytoma 10.2 KRT7 MUC1
34 gastrointestinal system benign neoplasm 10.2 KRT7 TP53
35 small cell carcinoma 10.2 KRT7 TP53
36 colorectal adenocarcinoma 10.2 KRT7 TP53
37 ovarian clear cell carcinoma 10.2 KRT7 TP53
38 cell type benign neoplasm 10.2 KRT7 TP53
39 vulva cancer 10.2 KRT7 TP53
40 localized hypertrophic neuropathy 10.2 MUC1 S100B
41 inverted papilloma 10.2 KRT7 TP53
42 sclerosing perineurioma 10.2 MUC1 S100B
43 germ cell and embryonal cancer 10.2 KRT7 TP53
44 mucinous adenocarcinoma 10.2 KRT7 MUC1
45 lung benign neoplasm 10.2 KRT7 TP53
46 ovary adenocarcinoma 10.2 KRT7 TP53
47 cavernous hemangioma 10.2 KRT7 MUC1
48 pericardial mesothelioma 10.2 KRT7 MUC1
49 intracranial cysts 10.2 MUC1 S100B
50 reticular perineurioma 10.2 MUC1 S100B

Graphical network of the top 20 diseases related to Spiradenoma:



Diseases related to Spiradenoma

Symptoms & Phenotypes for Spiradenoma

Drugs & Therapeutics for Spiradenoma

Search Clinical Trials , NIH Clinical Center for Spiradenoma

Genetic Tests for Spiradenoma

Anatomical Context for Spiradenoma

MalaCards organs/tissues related to Spiradenoma:

42
Skin, Smooth Muscle, Lymph Node

Publications for Spiradenoma

Articles related to Spiradenoma:

(show top 50) (show all 176)
# Title Authors Year
1
Eccrine spiradenoma of the nipple: Case report, differential diagnosis and literature review. ( 30806477 )
2019
2
Malignant transformation of a spiradenoma with blaschkoïd pattern. ( 30455896 )
2018
3
FDG PET/CT in Malignant Eccrine Spiradenoma. ( 28005641 )
2017
4
Sonographic appearance of an eccrine spiradenoma: A case report. ( 29271484 )
2017
5
Myoepithelial-Rich and Infiltrative Giant Vascular Eccrine Spiradenoma: A Unique Presentation of a Rare Adnexal Tumor. ( 28984693 )
2017
6
A Case of Eccrine Spiradenoma: A Rarely Seen Soft Tissue Tumor on the Extensor Surface of Arm. ( 28761313 )
2017
7
Eccrine Spiradenoma of the Scalp. ( 29090205 )
2017
8
Spiradenoma ( 28846324 )
2017
9
Eccrine spiradenoma mimicking a painful traumatic neuroma: case report. ( 29076781 )
2017
10
Ultrasonographic Features of Eccrine Spiradenoma. ( 29120034 )
2017
11
Eccrine spiradenoma: A rare adnexal tumor. ( 30082561 )
2017
12
Lymphangiectatic Variant of Eccrine Spiradenoma - A Diagnostic Challenge. ( 28806004 )
2016
13
A rare case of eccrine spiradenoma-treatment and management. ( 27069311 )
2016
14
Spiradenoma causing longitudinal splitting of the nail. ( 27663150 )
2016
15
Giant vascular eccrine spiradenoma of the leg: MR imaging findings. ( 27397887 )
2016
16
Giant Vascular Eccrine Spiradenoma. ( 26365030 )
2015
17
Zosteriform spiradenoma with spiradenocarcinoma: A rare entity. ( 26904446 )
2015
18
Sonographic and sonoelastographic findings of a rarely seen soft tissue tumor: eccrine spiradenoma. ( 26576987 )
2015
19
Malignant eccrine spiradenoma of the external ear. ( 26211868 )
2015
20
Inexplicable Co- Existence of Eccrine Spiradenoma and Lichen Planus in an old Case of Basal Cell Carcinoma. ( 25737995 )
2015
21
Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. ( 26563774 )
2015
22
Malignant eccrine breast spiradenoma. A case report and literature review. ( 26318134 )
2015
23
Trichoepithelioma and spiradenoma collision tumor. ( 25942028 )
2015
24
Eccrine Spiradenoma Arising from the Breast Skin. ( 26236527 )
2015
25
Giant eccrine spiradenoma mimicking a malignant tumor. ( 25566913 )
2015
26
Malignant Eccrine Spiradenoma of the Face. ( 26167988 )
2015
27
Spiradenocarcinoma in Preexisting Spiradenoma With a Large In Situ Adenocarcinoma Component. ( 25830720 )
2015
28
A serpentine inside eccrine spiradenoma: a new trichoscopic sign. ( 25878450 )
2015
29
Multiple Segmental Eccrine Spiradenoma with a Zosteriform Pattern: A Case Report and Literature Review. ( 26273161 )
2015
30
Eccrine spiradenoma in knee. ( 25284865 )
2014
31
Tubular Spitz Naevus Mimicking Eccrine Spiradenoma. ( 23756597 )
2014
32
Case of recurrence of spiradenoma in palpebral conjunctiva. ( 24969313 )
2014
33
A malignant eccrine spiradenoma of the scalp. ( 24842352 )
2014
34
Differential diagnosis of eccrine spiradenoma: A case report. ( 25187803 )
2014
35
Spiradenoma and cylindroma originate from the hair follicle bulge and not from the eccrine sweat gland: an immunohistochemical study with CD200 and other stem cell markers. ( 25354097 )
2014
36
Fine needle aspiration cytology of eccrine spiradenoma of back: report of a rare case. ( 25328342 )
2014
37
Cystic eccrine spiradenoma of the finger mimicking a ganglion. ( 25289292 )
2014
38
Infiltrative Recurrent Eccrine Spiradenoma of the Anterior Neck Treated Using Mohs Micrographic Surgery. ( 24118397 )
2013
39
Immunohistochemical characterization of non-epithelial cells in spiradenoma. ( 24580131 )
2013
40
Giant vascular eccrine spiradenoma mimicking calcifying epithelioma. ( 23961898 )
2013
41
Neonatal spiradenoma. ( 22747799 )
2013
42
Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma and eccrine spiradenoma. ( 24261740 )
2013
43
Malignant spiradenoma/cylindroma of the vulva. ( 23147883 )
2012
44
Dermatoscopic pattern of a spiradenoma. ( 23785623 )
2012
45
Painful eccrine spiradenoma containing nerve fibers: a case report. ( 22777362 )
2012
46
Eccrine spiradenoma arising in the breast misdiagnosed as an epidermal inclusion cyst. ( 21430945 )
2011
47
Malignant eccrine spiradenoma: a meta-analysis of reported cases. ( 20851376 )
2011
48
Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression. ( 21598248 )
2011
49
A rare case of giant malignant eccrine spiradenoma. ( 21342314 )
2011
50
Carcinosarcoma ex eccrine spiradenoma of the vulva: report of the first case. ( 21464722 )
2011

Variations for Spiradenoma

Expression for Spiradenoma

Search GEO for disease gene expression data for Spiradenoma.

Pathways for Spiradenoma

Pathways related to Spiradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 ACTC1 KRT7 MUC1

GO Terms for Spiradenoma

Cellular components related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.17 ACTC1 CYLD KRT14 KRT7 MUC1 S100B

Biological processes related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 8.96 MUC1 TP53
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.62 MUC1 TP53

Molecular functions related to Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 8.62 MUC1 TP53

Sources for Spiradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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