MCID: SPR028
MIFTS: 18

Spirochetes Disease

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Spirochetes Disease

MalaCards integrated aliases for Spirochetes Disease:

Name: Spirochetes Disease 53 55
Spirochaetales Infections 53 73

Classifications:



External Ids:

ICD10 33 A69.8
UMLS 73 C0037974

Summaries for Spirochetes Disease

MalaCards based summary : Spirochetes Disease, also known as spirochaetales infections, is related to acrodermatitis chronica atrophicans and acrodermatitis. An important gene associated with Spirochetes Disease is CFH (Complement Factor H). The drugs Ceftriaxone and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and brain.

Related Diseases for Spirochetes Disease

Diseases related to Spirochetes Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 acrodermatitis chronica atrophicans 9.7
2 acrodermatitis 9.7

Symptoms & Phenotypes for Spirochetes Disease

Drugs & Therapeutics for Spirochetes Disease

Drugs for Spirochetes Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4,Phase 3,Phase 2,Not Applicable 73384-59-5 5479530 5361919
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 564-25-0 54671203
3
Hydroxychloroquine Approved Phase 4 118-42-3 3652
4
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 59-46-1 4914
5
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
6
Clarithromycin Approved Phase 4 81103-11-9 84029
7
Penicillin G Approved, Vet_approved Phase 4,Phase 3,Not Applicable 61-33-6 5904
8
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5361202 5479529
9
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
10
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
11 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
13 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
14 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
15 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
16 penicillins Phase 4,Phase 3,Not Applicable
17 cefuroxime axetil Phase 4,Not Applicable
18 Cytochrome P-450 CYP3A Inhibitors Phase 4
19 Cytochrome P-450 Enzyme Inhibitors Phase 4
20 Penicillin G Benzathine Phase 4,Phase 3,Not Applicable
21 Penicillin G Procaine Phase 4,Phase 3,Not Applicable
22 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
23 Antitubercular Agents Phase 4,Not Applicable
24 Antirheumatic Agents Phase 4
25
Tenofovir Phase 4 147127-20-6 464205
26 Reverse Transcriptase Inhibitors Phase 4
27 Nucleic Acid Synthesis Inhibitors Phase 4
28 Anti-HIV Agents Phase 4
29 Anti-Retroviral Agents Phase 4
30 Antiviral Agents Phase 4
31
Heroin Approved, Illicit, Investigational Phase 3,Not Applicable 561-27-3 5462328
32
Methadone Approved Phase 3,Not Applicable 76-99-3 4095
33
Guaifenesin Approved, Investigational, Vet_approved Phase 3,Not Applicable 93-14-1 3516
34
Azithromycin Approved Phase 3,Phase 1,Phase 2 83905-01-5 55185 447043
35
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
36
Permethrin Approved, Investigational Phase 3 52645-53-1 40326
37 Analgesics Phase 3,Not Applicable
38 Respiratory System Agents Phase 3,Not Applicable
39 Central Nervous System Depressants Phase 3,Not Applicable
40 Chlorpheniramine, phenylpropanolamine drug combination Phase 3,Not Applicable
41 Narcotics Phase 3,Not Applicable
42 Analgesics, Opioid Phase 3,Not Applicable
43 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
44 Antitussive Agents Phase 3,Not Applicable
45 Gastrointestinal Agents Phase 2, Phase 3,Phase 1
46 PENTA Phase 3
47 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
48 glucocorticoids Phase 2, Phase 3
49
protease inhibitors Phase 2, Phase 3
50 Natriuretic Agents Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 104)
# Name Status NCT ID Phase Drugs
1 Study of Lyme Neuroborreliosis Unknown status NCT01635530 Phase 4 Doxycycline;Ceftriaxone
2 Persistent Lyme Empiric Antibiotic Study Europe Completed NCT01207739 Phase 4 Doxycycline;Clarithromycin and hydroxychloroquine;Placebo
3 Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Completed NCT02611765 Phase 4 Benzathine penicillin G intramuscular 7.2 million units;Benzathine penicillin G intramuscular 2.4 million units
4 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
5 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
6 Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin Recruiting NCT02884115 Phase 4 benzathine penicillin
7 The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Recruiting NCT02871505 Phase 4 Benzathine Penicillin G
8 One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis Recruiting NCT02857959 Phase 4 Benzathine Penicillin G
9 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Not yet recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
10 Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia Unknown status NCT02454816 Phase 2, Phase 3
11 (Men Who Have Sex With Men) MSM Community Intervention Trial Unknown status NCT01068015 Phase 3
12 Injecting Drug Use Community Intervention Trial Unknown status NCT01108614 Phase 3
13 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
14 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
15 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seropositive Chronic Lyme Disease Completed NCT00001101 Phase 3 ceftriaxone;doxycycline
16 A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease Completed NCT00000938 Phase 3 ceftriaxone;doxycycline
17 Study and Treatment of Post Lyme Disease (STOP-LD) Completed NCT00000937 Phase 3 Antibiotics
18 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
19 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3
20 Lyme Disease Prevention Program Completed NCT00000432 Phase 3
21 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment
22 Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis Completed NCT00138801 Phase 3 Ceftriaxone;Doxycycline
23 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
24 Six Versus Two Weeks Treatment With Doxycycline in Lyme Neuroborreliosis Enrolling by invitation NCT02553473 Phase 3 Doxycycline;Placebo
25 Desmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis Terminated NCT00592566 Phase 2, Phase 3 Dexamethasone, desmopressin
26 Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes Terminated NCT00958139 Phase 3
27 Phase 1/2 Lyme Vaccine Study Completed NCT01504347 Phase 1, Phase 2
28 Safety, Skin and Plasma Concentration of Azithromycin Dermal Formulation Completed NCT01243008 Phase 1, Phase 2 Application of SHB001
29 Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Completed NCT00213031 Phase 2 Carraguard (PC-515)
30 Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission Completed NCT00213018 Phase 2 Carraguard (PC-515)
31 Lay Health Advisors for Sexually Transmitted Disease Prevention Completed NCT00207506 Phase 1, Phase 2
32 Brain Imaging and Retreatment Study of Persistent Lyme Disease Completed NCT00037479 Phase 2 ceftriaxone
33 Xenodiagnosis After Antibiotic Treatment for Lyme Disease Recruiting NCT02446626 Phase 1, Phase 2
34 Safer Sex Program for Young African-American Men Recruiting NCT01439503 Phase 2
35 Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand Completed NCT00213057 Phase 1 Carraguard (PC-515)
36 Study Assessing the Safety, Immunogenicity and Dose Response of VLA15, A New Vaccine Candidate Against Lyme Borreliosis Active, not recruiting NCT03010228 Phase 1
37 A School-Based Intervention to Reduce Lyme Disease Unknown status NCT00594997 Not Applicable
38 Syphilis Treatment of Partners Trial Unknown status NCT02262390 Not Applicable
39 Meditation and Stretching for Post Treatment Lyme Disease Syndrome Unknown status NCT02344537 Not Applicable
40 A Methadone Maintenance Treatment Outcome Study in Three Provinces in China Unknown status NCT01315054 Not Applicable
41 Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM) Unknown status NCT01300689
42 Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis Unknown status NCT00942006 Not Applicable doxycycline;ceftriaxone
43 Obtaining and Storing Human Blood, Urine, and Fecal Samples for Spirochete-Related Epidemiological Research Completed NCT01089153
44 Seroprevalence Study to Evaluate the Persistence of Anti-leptospira Antibody in Subjects Vaccinated With Spirolept® Vaccine Completed NCT03497572
45 Searching for Persistence of Infection in Lyme Disease Completed NCT01143558 Early Phase 1
46 Feasibility of Introducing an Onsite Test for Syphilis in the Package of Antenatal Care in Burkina Faso Completed NCT03156751
47 Dual Rapid HIV & Syphilis Tests in Zambia Completed NCT02445846
48 Preventing Congenital Syphilis Completed NCT02353117 Not Applicable
49 Sofia 2 Lyme FIA Whole Blood Clinical Study Completed NCT03238274
50 Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM Completed NCT02257658 Not Applicable Doxycycyline

Search NIH Clinical Center for Spirochetes Disease

Genetic Tests for Spirochetes Disease

Anatomical Context for Spirochetes Disease

MalaCards organs/tissues related to Spirochetes Disease:

41
Testes, Skin, Brain, Whole Blood

Publications for Spirochetes Disease

Articles related to Spirochetes Disease:

# Title Authors Year
1
Acrodermatitis chronica atrophicans, erythema chronicum migrans and lymphadenosis benigna cutis--spirochetal diseases? ( 6197845 )
1983

Variations for Spirochetes Disease

Expression for Spirochetes Disease

Search GEO for disease gene expression data for Spirochetes Disease.

Pathways for Spirochetes Disease

GO Terms for Spirochetes Disease

Sources for Spirochetes Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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