MCID: SPT007
MIFTS: 39

Spitz Nevus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Spitz Nevus

MalaCards integrated aliases for Spitz Nevus:

Name: Spitz Nevus 54 56
Epithelioid and Spindle Cell Nevus 74
Spitz Naevus 54
Spitz Nevi 54

Classifications:



External Ids:

UMLS 74 C0206739

Summaries for Spitz Nevus

NIH Rare Diseases : 54 Spitz nevus are non-cancerous skin lesions that tend to be dome-shaped, red, reddish-brown or dark colored. They usually develop on the face or limbs of young children. They tend to grow quickly initially, but then stabilize or even disappear after a period of time. Spitz nevi can be very difficult to distinguish from melanoma, as a result treatment tends to involve excision of the nevi.

MalaCards based summary : Spitz Nevus, also known as epithelioid and spindle cell nevus, is related to melanoma and keratoacanthoma. An important gene associated with Spitz Nevus is HRAS (HRas Proto-Oncogene, GTPase), and among its related pathways/superpathways are MAPK signaling pathway and Endometrial cancer. Affiliated tissues include skin, cervix and thyroid, and related phenotypes are neoplasm and no phenotypic analysis

Wikipedia : 77 A Spitz nevus is a benign skin lesion. A type of melanocytic nevus, it affects the epidermis and... more...

Related Diseases for Spitz Nevus

Diseases related to Spitz Nevus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 melanoma 30.9 BRAF CDKN2A TP53
2 keratoacanthoma 30.0 MKI67 TP53
3 sarcoma 29.9 BRAF HRAS TP53
4 skin melanoma 29.8 BRAF CDKN2A TP53
5 glioblastoma 29.5 BRAF CDKN2A HRAS TP53
6 melanocytic nevus syndrome, congenital 12.0
7 spitzoid melanoma 11.7
8 melanoma in congenital melanocytic nevus 10.5
9 hemangioma 10.3
10 tièche-jadassohn nevus 10.3
11 prostate adenoid cystic carcinoma 10.3 HRAS LRRC56
12 serous cystadenocarcinoma 10.2 HRAS TP53
13 cystadenocarcinoma 10.2 HRAS TP53
14 carcinosarcoma 10.2 HRAS TP53
15 biliary papillomatosis 10.2 HRAS TP53
16 epithelial-myoepithelial carcinoma 10.2 HRAS TP53
17 leopard syndrome 10.2 BRAF HRAS
18 mixed cell type cancer 10.2 HRAS TP53
19 liver angiosarcoma 10.2 HRAS TP53
20 nevus, epidermal 10.2
21 nodular malignant melanoma 10.2
22 dermatitis 10.2
23 granulomatous dermatitis 10.2
24 ampulla of vater cancer 10.2 HRAS TP53
25 melanomatosis 10.2 CDKN2A HRAS
26 gastrointestinal system benign neoplasm 10.2 HRAS TP53
27 ovary adenocarcinoma 10.2 HRAS TP53
28 bile duct adenocarcinoma 10.2 HRAS TP53
29 intestinal benign neoplasm 10.2 HRAS TP53
30 nevus of ota 10.2 BRAF TP53
31 gallbladder adenoma 10.2 CDKN2A HRAS
32 hyperplastic polyposis syndrome 10.2 BRAF TP53
33 lung benign neoplasm 10.1 HRAS TP53
34 mature teratoma 10.1 BRAF TP53
35 pleomorphic xanthoastrocytoma 10.1 BRAF TP53
36 malignant ovarian surface epithelial-stromal neoplasm 10.1 HRAS TP53
37 ovary epithelial cancer 10.1 HRAS TP53
38 cardiofaciocutaneous syndrome 1 10.1 BRAF HRAS
39 central nervous system melanocytic neoplasm 10.1 CDKN2A HRAS
40 pancreas disease 10.1 HRAS TP53
41 histiocytic sarcoma 10.1 BRAF CDKN2A
42 keratinizing squamous cell carcinoma 10.1 CDKN2A TP53
43 bladder carcinoma in situ 10.1 CDKN2A TP53
44 vulva squamous cell carcinoma 10.1 CDKN2A TP53
45 acral lentiginous melanoma 10.1 BRAF CDKN2A
46 scrotal carcinoma 10.1 CDKN2A TP53
47 thyroid lymphoma 10.1 CDKN2A TP53
48 vulvar disease 10.1 CDKN2A TP53
49 bartholin's gland disease 10.1 CDKN2A TP53
50 anal squamous cell carcinoma 10.1 CDKN2A TP53

Graphical network of the top 20 diseases related to Spitz Nevus:



Diseases related to Spitz Nevus

Symptoms & Phenotypes for Spitz Nevus

MGI Mouse Phenotypes related to Spitz Nevus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 BRAF CDKN2A HRAS TP53
2 no phenotypic analysis MP:0003012 8.92 CDKN2A HRAS MKI67 TP53

Drugs & Therapeutics for Spitz Nevus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Artificial Intelligence-assisted Evaluation of Pigmented Skin Lesions Recruiting NCT03362138

Search NIH Clinical Center for Spitz Nevus

Genetic Tests for Spitz Nevus

Anatomical Context for Spitz Nevus

MalaCards organs/tissues related to Spitz Nevus:

42
Skin, Cervix, Thyroid, Tongue, Brain, Ovary, Pancreas

Publications for Spitz Nevus

Articles related to Spitz Nevus:

(show top 50) (show all 158)
# Title Authors Year
1
Spitz Nevus Intermingling With Hemangioma, Angiomatoid Spitz Nevus, Angiotropism, and Vascular Co-option Viewed With Differing Availability Heuristics. ( 28398920 )
2018
2
Genomic Assessment of Blitz Nevi Suggests Classification as a Subset of Blue Nevus Rather Than Spitz Nevus: Clinical, Histopathologic, and Molecular Analysis of 18 Cases. ( 28475519 )
2018
3
Parallel ridge dermoscopic pattern in plantar atypical Spitz nevus. ( 28862772 )
2018
4
Acral pigmented Spitz nevus in a child with transepidermal migration of melanocytes: Dermoscopic and reflectance confocal microscopic features. ( 29314193 )
2018
5
Reevaluation of established and new criteria in differential diagnosis of Spitz nevus and melanoma. ( 29417221 )
2018
6
Angiomatoid and desmoplastic Spitz nevus presenting as a keloidal nodule. ( 29582459 )
2018
7
Patient Perspectives: What is a Spitz nevus? ( 30397961 )
2018
8
Agminated Spitz nevus arising in normal skin with redundant HRAS mutation. ( 27694096 )
2017
9
Polypoid Spitz Nevus With a Halo Reaction. ( 28135210 )
2017
10
The diagnosis and management of the Spitz nevus in the pediatric population: a systematic review and meta-analysis protocol. ( 28407793 )
2017
11
THE FAST CLINICAL EVOLUTION OF A SPITZ NEVUS: THREE-YEAR FOLLOW-UP OF A CHILD. ( 28977136 )
2017
12
Spitz Nevus Intermingling With a Hemangioma. ( 27043337 )
2016
13
Balloon-cell variant of the Spitz nevus. ( 26147249 )
2016
14
Spitz nevus arising in the eyelid of a teenager. ( 26498574 )
2016
15
Spitz Nevus: A Rare Lesion of the Oral Cavity. ( 27001333 )
2016
16
A hypopigmented atypical spitz nevus. ( 27176085 )
2016
17
Pediatric pigmented Spitz nevus: A natural course toward involution assessed with dermoscopy. ( 27444090 )
2016
18
Pigmented Spitz nevus simulating a solitary angiokeratoma. ( 25773434 )
2015
19
Ulcerated Spitz nevus masquerading as a juvenile xanthogranuloma. ( 25441121 )
2015
20
Desmoplastic Spitz Nevus Combined With Cutaneous Leiomyoma: A Rare Collision Tumor. ( 25171428 )
2015
21
Dermoscopy of pigmented variant of acral Spitz nevus. ( 25500025 )
2015
22
Recurrent Spitz nevus with multiple satellite lesions on perineum. ( 25566925 )
2015
23
Spitz nevus on the palm with crista transverse dots/dotted lines revealed by dermoscopic examination. ( 25807954 )
2015
24
Agminated spitz nevus on sole of elderly. ( 25814764 )
2015
25
Spitz Nevus on the Perianal Area of a Child: An Unusual Location. ( 26719661 )
2015
26
An atypical variant of phacomatosis pigmentokeratotica: verrucous epidermal nevus, speckled lentiginous nevus, and Spitz nevus associated with scoliosis. ( 24877171 )
2014
27
Intraoral Spitz nevus: case report and literature review. ( 24139994 )
2014
28
Congenital Spitz nevus on the foot. ( 24506180 )
2014
29
Spitz nevus on the sole of the foot presenting with transepidermal elimination. ( 24855573 )
2014
30
Lipoblastoid/signet-ring cell-rich Spitz nevus: a hitherto unreported microscopic variant. ( 24977308 )
2014
31
Compound clear cell sarcoma misdiagnosed as a Spitz nevus. ( 23980901 )
2013
32
Pseudogranulomatous Spitz nevus: a variant of Spitz nevus with heavy inflammatory infiltrate mimicking a granulomatous dermatitis. ( 22985334 )
2013
33
Spitz nevus arising upon a congenital glomuvenous malformation. ( 22304367 )
2013
34
Neuropilin-2 as a useful marker in the differentiation between Spitzoid malignant melanoma and Spitz nevus. ( 22954749 )
2013
35
Inflammatory changes with features of chronic leukocytoclastic vasculitis in a Spitz nevus. ( 24033918 )
2013
36
Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview. ( 24075547 )
2013
37
Solitary spindle cell xanthogranuloma mimicking a spitz nevus. ( 24257193 )
2013
38
Verrucous spitz nevus in a Japanese female. ( 24348378 )
2013
39
HRAS-mutated Spitz nevus on the cheek in a middle-aged man. ( 22113246 )
2012
40
Characteristics of spitzoid melanoma and clues for differential diagnosis with spitz nevus. ( 22257900 )
2012
41
Spitz nevus with Homer-Wright rosette-like structures. ( 22356919 )
2012
42
What is your diagnosis? Desmoplastic Spitz nevus. ( 22439303 )
2012
43
Spitz nevus and Reed nevus. ( 22714748 )
2012
44
Dermoscopic findings of pigmented Spitz nevus of the sole. ( 22779696 )
2012
45
Desmoplastic nevus: An entity distinct from spitz nevus and blue nevus. ( 21124206 )
2011
46
Polypoid Spitz nevus: two cases evaluated with genetic technique, prolonged follow up, and sentinel lymph node biopsy. ( 21645037 )
2011
47
Dermatoscopy of an angiomatoid spitz nevus. ( 21712688 )
2011
48
Acral pigmented spitz nevus that clinically mimicked acral lentiginous malignant melanoma. ( 21747632 )
2011
49
The spitz nevus: review and update. ( 19914455 )
2010
50
Spitz nevus in a Hispanic population: a clinicopathological study of 130 cases. ( 20098300 )
2010

Variations for Spitz Nevus

Expression for Spitz Nevus

Search GEO for disease gene expression data for Spitz Nevus.

Pathways for Spitz Nevus

Pathways related to Spitz Nevus according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1 12.52 BRAF HRAS TP53
2
Show member pathways
12.48 BRAF CDKN2A HRAS TP53
3
Show member pathways
12.46 BRAF HRAS TP53
4
Show member pathways
12.43 BRAF HRAS TP53
5 12.43 BRAF CDKN2A HRAS TP53
6
Show member pathways
12.32 BRAF HRAS TP53
7
Show member pathways
12.29 BRAF HRAS TP53
8 12.27 CDKN2A HRAS TP53
9 12.26 CDKN2A MKI67 TP53
10
Show member pathways
12.25 BRAF HRAS TP53
11
Show member pathways
12.22 BRAF CDKN2A HRAS TP53
12
Show member pathways
12.22 BRAF CDKN2A HRAS TP53
13 12.08 CDKN2A HRAS TP53
14 12 BRAF HRAS TP53
15
Show member pathways
11.99 BRAF HRAS TP53
16 11.99 CDKN2A HRAS TP53
17
Show member pathways
11.94 BRAF HRAS TP53
18 11.87 CDKN2A HRAS TP53
19
Show member pathways
11.86 BRAF HRAS TP53
20
Show member pathways
11.81 BRAF HRAS TP53
21 11.6 CDKN2A HRAS TP53
22 11.51 BRAF HRAS
23 11.5 BRAF CDKN2A HRAS TP53
24 11.49 HRAS TP53
25 11.48 HRAS TP53
26 11.48 HRAS TP53
27
Show member pathways
11.47 BRAF HRAS
28 11.42 BRAF HRAS
29 11.37 CDKN2A TP53
30 11.35 CDKN2A TP53
31 11.28 HRAS TP53
32 11.28 BRAF CDKN2A HRAS TP53
33 11.26 BRAF HRAS
34 11.13 BRAF HRAS
35 11.09 CDKN2A TP53
36 10.89 CDKN2A TP53
37
Show member pathways
10.88 CDKN2A TP53
38 10.79 BRAF CDKN2A HRAS TP53

GO Terms for Spitz Nevus

Biological processes related to Spitz Nevus according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.65 CDKN2A HRAS TP53
2 cell proliferation GO:0008283 9.63 HRAS MKI67 TP53
3 cellular response to drug GO:0035690 9.49 BRAF TP53
4 intrinsic apoptotic signaling pathway GO:0097193 9.43 HRAS TP53
5 cell aging GO:0007569 9.4 HRAS TP53
6 cellular response to gamma radiation GO:0071480 9.37 HRAS TP53
7 cell cycle arrest GO:0007050 9.33 CDKN2A HRAS TP53
8 cellular senescence GO:0090398 9.32 CDKN2A HRAS
9 replicative senescence GO:0090399 9.26 CDKN2A TP53
10 positive regulation of gene expression GO:0010628 9.26 BRAF CDKN2A HRAS TP53
11 Ras protein signal transduction GO:0007265 8.8 CDKN2A HRAS TP53

Molecular functions related to Spitz Nevus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Spitz Nevus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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