MCID: SPT007
MIFTS: 35

Spitz Nevus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Spitz Nevus

MalaCards integrated aliases for Spitz Nevus:

Name: Spitz Nevus 52 54
Epithelioid and Spindle Cell Nevus 71
Spitz Naevus 52
Spitz Nevi 52

Classifications:



External Ids:

UMLS 71 C0206739

Summaries for Spitz Nevus

NIH Rare Diseases : 52 Spitz nevus are non-cancerous skin lesions that tend to be dome-shaped, red, reddish-brown or dark colored. They usually develop on the face or limbs of young children. They tend to grow quickly initially, but then stabilize or even disappear after a period of time. Spitz nevi can be very difficult to distinguish from melanoma , as a result treatment tends to involve excision of the nevi.

MalaCards based summary : Spitz Nevus, also known as epithelioid and spindle cell nevus, is related to spitzoid melanoma and acral lentiginous melanoma. An important gene associated with Spitz Nevus is HRAS (HRas Proto-Oncogene, GTPase), and among its related pathways/superpathways are Endometrial cancer and Development HGF signaling pathway. Affiliated tissues include skin, thyroid and lymph node, and related phenotypes are neoplasm and no phenotypic analysis

Wikipedia : 74 A Spitz nevus is a benign skin lesion. A type of melanocytic nevus, it affects the epidermis and... more...

Related Diseases for Spitz Nevus

Diseases related to Spitz Nevus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 spitzoid melanoma 33.1 HRAS BRAF
2 acral lentiginous melanoma 30.2 CDKN2A BRAF
3 melanoma 30.2 TP53 HRAS CDKN2A BRAF
4 plexiform neurofibroma 29.9 TP53 HRAS CDKN2A
5 rhabdomyosarcoma 29.8 TP53 HRAS CDKN2A
6 keratosis 29.7 TP53 HRAS CDKN2A
7 keratoacanthoma 29.7 TP53 MKI67
8 nodular malignant melanoma 29.7 TP53 HRAS CDKN2A BRAF
9 skin melanoma 29.4 TP53 HRAS CDKN2A BRAF
10 histiocytoma 29.4 TP53 CDKN2A
11 glioblastoma multiforme 29.2 TP53 HRAS CDKN2A BRAF
12 leukemia 29.2 TP53 HRAS CDKN2A BRAF
13 basal cell carcinoma 29.0 TP53 MKI67 CDKN2A
14 squamous cell carcinoma 28.3 TP53 MKI67 HRAS CDKN2A BRAF
15 melanocytic nevus syndrome, congenital 11.6
16 tièche-jadassohn nevus 10.5
17 hemangioma 10.5
18 cutaneous fibrous histiocytoma 10.4
19 melanoma in congenital melanocytic nevus 10.4
20 neurofibroma 10.4
21 dowling-degos disease 1 10.2
22 benign struma ovarii 10.2 HRAS BRAF
23 nevus, epidermal 10.2
24 dermatitis 10.2
25 granulomatous dermatitis 10.2
26 keloid disorder 10.2
27 pyogenic granuloma 10.2
28 superficial spreading melanoma 10.2
29 adult teratoma 10.2 TP53 HRAS
30 squamous cell papilloma 10.2 TP53 HRAS
31 wolffian duct adenocarcinoma 10.2 TP53 HRAS
32 biliary tract benign neoplasm 10.2 TP53 HRAS
33 tumor of exocrine pancreas 10.2 TP53 HRAS
34 appendix disease 10.2 TP53 HRAS
35 villous adenoma 10.2 HRAS BRAF
36 appendix cancer 10.2 TP53 HRAS
37 papillary adenoma 10.2 TP53 HRAS
38 nevus of ota 10.2 TP53 BRAF
39 endometrioid ovary carcinoma 10.2 TP53 HRAS
40 hyperplastic polyposis syndrome 10.2 TP53 BRAF
41 nasal cavity cancer 10.2 TP53 HRAS
42 female reproductive endometrioid cancer 10.2 TP53 HRAS
43 liver benign neoplasm 10.2 TP53 HRAS
44 epithelial-myoepithelial carcinoma 10.2 TP53 HRAS
45 myoepithelial carcinoma 10.1 TP53 HRAS
46 uterine body mixed cancer 10.1 TP53 HRAS
47 skin papilloma 10.1 TP53 HRAS
48 thyroid gland anaplastic carcinoma 10.1 TP53 BRAF
49 lip cancer 10.1 TP53 BRAF
50 duodenum disease 10.1 TP53 HRAS

Symptoms & Phenotypes for Spitz Nevus

MGI Mouse Phenotypes related to Spitz Nevus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 BRAF CDKN2A HRAS TP53
2 no phenotypic analysis MP:0003012 8.92 CDKN2A HRAS MKI67 TP53

Drugs & Therapeutics for Spitz Nevus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dermoscopy Evaluation of Pigmented Skin Lesions by a Neuronal Network Clinical Decision Support: an Open Prospective Non Interventional Study Unknown status NCT03362138

Search NIH Clinical Center for Spitz Nevus

Genetic Tests for Spitz Nevus

Anatomical Context for Spitz Nevus

MalaCards organs/tissues related to Spitz Nevus:

40
Skin, Thyroid, Lymph Node, Lung, Breast, Ovary, Appendix

Publications for Spitz Nevus

Articles related to Spitz Nevus:

(show top 50) (show all 654)
# Title Authors PMID Year
1
BRAF and NRAS mutations in spitzoid melanocytic lesions. 54 61
16799476 2006
2
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma. 54 61
16096402 2005
3
Genetic similarities between Spitz nevus and Spitzoid melanoma in children. 54 61
15503312 2004
4
Absence of BRAF gene mutations differentiates spitz nevi from malignant melanoma. 54 61
15330192 2004
5
Spitz Tumors With ROS1 Fusions: A Clinicopathological Study of 6 Cases, Including FISH for Chromosomal Copy Number Alterations and Mutation Analysis Using Next-Generation Sequencing. 61
31361613 2020
6
Ciliation index is a useful diagnostic tool in challenging spitzoid melanocytic neoplasms. 61
31978411 2020
7
A Case of Adjacent, Clonally Distinct Borderline Melanocytic Tumors on the Arm. 61
31268925 2020
8
Spitz melanoma is a distinct subset of spitzoid melanoma. 61
31900433 2020
9
A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3-SCAPER gene fusion. 61
31437301 2020
10
Pediatric cellular neurothekeoma: Seven cases and systematic review of the literature. 61
31930561 2020
11
BRCA1-associated protein (BAP1)-inactivated melanocytic tumors. 61
31233225 2019
12
Eruptive disseminated Spitz nevi - a case report. 61
31899063 2019
13
Spitz nevi in older adults: correlation of histopathology with results of a gene expression profiling assay. 61
31866264 2019
14
Assessment of Shave Removal Without Further Excision in the Treatment of Spitz Nevi: A Retrospective Study of 58 Cases. 61
31808712 2019
15
Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations. 61
31719662 2019
16
Spitz Nevus and Other Spitzoid Tumors in Children. Part 2: Cytogenetic and Molecular Features. Prognosis and Treatment. 61
31739993 2019
17
Dermoscopic findings of Spitz nevus on acral volar skin. 61
31571613 2019
18
Spitz Nevus and Other Spitzoid Tumors in Children -Part 1: Clinical, Histopathologic, and Immunohistochemical Features. 61
31787210 2019
19
The morphologic spectrum of germline-mutated BAP1-inactivated melanocytic tumors includes lesions with conventional nevic melanocytes: A case report and review of literature. 61
31206729 2019
20
Corresponding anaplastic lymphoma kinase-tropomyosin 3 (ALK-TPM3) fusion in a patient with a primary cutaneous anaplastic large-cell lymphoma and a Spitz nevus. 61
31687467 2019
21
Prevalence and Preliminary Validation of Screening Criteria to Identify Carriers of Germline BAP1 Mutations. 61
31323388 2019
22
Utility of p16-Ki-67-HMB45 score in sorting benign from malignant Spitz tumors. 61
31351802 2019
23
Assessment of Second-Opinion Strategies for Diagnoses of Cutaneous Melanocytic Lesions. 61
31603483 2019
24
Dermoscopy of Spitz/Reed naevi and management. 61
30762033 2019
25
Nestin Expression in Spitzoid Lesions: An Immunohistochemical Characterization With Clinical and Dermoscopic Correlations. 61
30212379 2019
26
The Amount of Melanin Influences p16 Loss in Spitzoid Melanocytic Lesions: Correlation With CDKN2A Status by FISH and MLPA. 61
29489509 2019
27
The first case of vaginal angiomatoid Spitz nevus causing vaginal bleeding. 61
31338348 2019
28
Observational Study Examining the Diagnostic Practice of Ki67 Staining for Melanocytic Lesions. 61
31233404 2019
29
Expression of estrogen receptors in spitz and reed nevi. 61
31355620 2019
30
The large spectrum of Spitzoid tumors: a retrospective survival study. 61
28704985 2019
31
Fusion of ALK to the melanophilin gene MLPH in pediatric Spitz nevi. 61
30857967 2019
32
Expression of p15 in a spectrum of spitzoid melanocytic neoplasms. 61
30666677 2019
33
[Clinicopathological features and prognosis of ALK-positive Spitz tumors]. 61
30831648 2019
34
Melanoma frequency among symmetrical Spitzoid-looking lesions: a retrospective study. 61
28528541 2019
35
Melanoma and melanocytic nevi in pediatric patients: a single institution experience. 61
28290622 2019
36
Reflectance confocal microscopy for the noninvasive diagnosis of cutaneous juvenile xanthogranuloma. 61
30019531 2019
37
Atypical melanocytic lesions: a historical overview. 61
31556548 2019
38
Molecular profiling of Spitz nevi identified by digital RNA counting. 61
30095598 2018
39
Plexiform Atypical Spitz Tumor With Rosette-Like Giant Cells: A Histologic and Immunohistochemical Study on a Case Suggesting Ganglioneuroblastic Differentiation: Review of the Literature and Considerations on Histogenesis. 61
29771688 2018
40
PRAME Expression in Melanocytic Tumors. 61
30045064 2018
41
Patient Perspectives: What is a Spitz nevus? 61
30397961 2018
42
Desmoplastic intradermal spitz nevi arising within red tattoo ink. 61
30695974 2018
43
A Diagnostic Algorithm Combining Immunohistochemistry and Molecular Cytogenetics to Diagnose Challenging Melanocytic Tumors. 61
28362709 2018
44
Prevalence of ALK gene alterations among the spectrum of plexiform spitzoid lesions. 61
29920315 2018
45
p16. 61
30076191 2018
46
Multiple Spitz nevi after allogeneic hematopoietic stem cell transplantation. 61
29943855 2018
47
Rare Variant of Agminated Spitz Nevi on a Hypopigmented Background and Segmental Distribution: Case Report and Review of Literature. 61
29533278 2018
48
Genomic Fusions in Pigmented Spindle Cell Nevus of Reed. 61
29794873 2018
49
ALK Rearrangements Are Infrequent in Cellular Blue Nevus and Deep Penetrating Nevus. 61
29923908 2018
50
Angiomatoid and desmoplastic Spitz nevus presenting as a keloidal nodule. 61
29582459 2018

Variations for Spitz Nevus

Expression for Spitz Nevus

Search GEO for disease gene expression data for Spitz Nevus.

Pathways for Spitz Nevus

Pathways related to Spitz Nevus according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.48 TP53 HRAS CDKN2A BRAF
2
Show member pathways
12.47 TP53 HRAS BRAF
3 12.43 TP53 HRAS CDKN2A BRAF
4
Show member pathways
12.42 TP53 HRAS BRAF
5
Show member pathways
12.37 TP53 HRAS BRAF
6 12.29 TP53 HRAS CDKN2A
7
Show member pathways
12.29 TP53 HRAS CDKN2A BRAF
8 12.25 TP53 MKI67 CDKN2A
9
Show member pathways
12.25 TP53 HRAS BRAF
10
Show member pathways
12.24 TP53 HRAS BRAF
11
Show member pathways
12.15 TP53 HRAS CDKN2A BRAF
12 12.08 TP53 HRAS CDKN2A
13 12.02 TP53 HRAS BRAF
14 12 TP53 HRAS CDKN2A
15
Show member pathways
11.97 TP53 HRAS BRAF
16
Show member pathways
11.89 TP53 HRAS BRAF
17
Show member pathways
11.89 TP53 HRAS BRAF
18 11.87 TP53 HRAS CDKN2A
19
Show member pathways
11.84 TP53 HRAS BRAF
20 11.6 TP53 HRAS CDKN2A
21 11.5 TP53 HRAS CDKN2A BRAF
22 11.43 HRAS BRAF
23 11.38 TP53 CDKN2A
24 11.35 TP53 CDKN2A
25 11.28 TP53 HRAS
26 11.28 TP53 HRAS CDKN2A BRAF
27 11.26 HRAS BRAF
28 11.2 HRAS BRAF
29 11.11 HRAS BRAF
30 11.09 TP53 CDKN2A
31
Show member pathways
10.9 TP53 CDKN2A
32 10.89 TP53 CDKN2A
33 10.79 TP53 HRAS CDKN2A BRAF

GO Terms for Spitz Nevus

Biological processes related to Spitz Nevus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterooligomerization GO:0051291 9.46 HRAS BRAF
2 intrinsic apoptotic signaling pathway GO:0097193 9.43 TP53 HRAS
3 cellular response to gamma radiation GO:0071480 9.4 TP53 HRAS
4 cell aging GO:0007569 9.37 TP53 HRAS
5 cell cycle arrest GO:0007050 9.33 TP53 HRAS CDKN2A
6 cellular senescence GO:0090398 9.32 HRAS CDKN2A
7 replicative senescence GO:0090399 9.26 TP53 CDKN2A
8 positive regulation of gene expression GO:0010628 9.26 TP53 HRAS CDKN2A BRAF
9 Ras protein signal transduction GO:0007265 8.8 TP53 HRAS CDKN2A

Molecular functions related to Spitz Nevus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.96 TP53 CDKN2A
2 protein C-terminus binding GO:0008022 8.8 TP53 MKI67 HRAS

Sources for Spitz Nevus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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