MCID: SPT007
MIFTS: 40

Spitz Nevus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Spitz Nevus

MalaCards integrated aliases for Spitz Nevus:

Name: Spitz Nevus 53 55
Epithelioid and Spindle Cell Nevus 73
Spitz Naevus 53
Spitz Nevi 53

Classifications:



External Ids:

UMLS 73 C0206739

Summaries for Spitz Nevus

NIH Rare Diseases : 53 Spitz nevus are non-cancerous skin lesions that tend to be dome-shaped, red, reddish-brown or dark colored. They usually develop on the face or limbs of young children. They tend to grow quickly initially, but then stabilize or even disappear after a period of time. Spitz nevi can be very difficult to distinguish from melanoma, as a result treatment tends to involve excision of the nevi.

MalaCards based summary : Spitz Nevus, also known as epithelioid and spindle cell nevus, is related to melanoma and keratoacanthoma. An important gene associated with Spitz Nevus is HRAS (HRas Proto-Oncogene, GTPase), and among its related pathways/superpathways are MAPK signaling pathway and Endometrial cancer. Affiliated tissues include skin, tongue and lung, and related phenotypes are neoplasm and no phenotypic analysis

Wikipedia : 76 A Spitz nevus (also known as an epithelioid and spindle-cell nevus,benign juvenile melanoma, and... more...

Related Diseases for Spitz Nevus

Diseases related to Spitz Nevus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 melanoma 31.0 BRAF CDKN2A TP53
2 keratoacanthoma 30.0 MKI67 TP53
3 sarcoma 29.9 BRAF HRAS TP53
4 skin melanoma 29.8 BRAF CDKN2A TP53
5 glioblastoma 29.7 BRAF CDKN2A HRAS TP53
6 melanocytic nevus syndrome, congenital 12.0
7 hemangioma 10.2
8 tièche-jadassohn nevus 10.2
9 prostate adenoid cystic carcinoma 10.2 HRAS LRRC56
10 nevus, epidermal 10.2
11 nodular malignant melanoma 10.2
12 dermatitis 10.2
13 granulomatous dermatitis 10.2
14 serous cystadenocarcinoma 10.2 HRAS TP53
15 cystadenocarcinoma 10.2 HRAS TP53
16 carcinosarcoma 10.1 HRAS TP53
17 biliary papillomatosis 10.1 HRAS TP53
18 epithelial-myoepithelial carcinoma 10.1 HRAS TP53
19 leopard syndrome 10.1 BRAF HRAS
20 mixed cell type cancer 10.1 HRAS TP53
21 liver angiosarcoma 10.1 HRAS TP53
22 ampulla of vater cancer 10.1 HRAS TP53
23 melanomatosis 10.1 CDKN2A HRAS
24 gastrointestinal system benign neoplasm 10.1 HRAS TP53
25 bile duct adenocarcinoma 10.1 HRAS TP53
26 ovary adenocarcinoma 10.1 HRAS TP53
27 intestinal benign neoplasm 10.1 HRAS TP53
28 nevus of ota 10.1 BRAF TP53
29 gallbladder adenoma 10.1 CDKN2A HRAS
30 hyperplastic polyposis syndrome 10.1 BRAF TP53
31 lung benign neoplasm 10.1 HRAS TP53
32 mature teratoma 10.1 BRAF TP53
33 pleomorphic xanthoastrocytoma 10.1 BRAF TP53
34 malignant ovarian surface epithelial-stromal neoplasm 10.1 HRAS TP53
35 ovary epithelial cancer 10.1 HRAS TP53
36 cardiofaciocutaneous syndrome 1 10.1 BRAF HRAS
37 central nervous system melanocytic neoplasm 10.1 CDKN2A HRAS
38 pancreas disease 10.1 HRAS TP53
39 bladder squamous cell carcinoma 10.1 CDKN2A TP53
40 keratinizing squamous cell carcinoma 10.1 CDKN2A TP53
41 glioma susceptibility 1 10.1
42 langerhans cell histiocytosis 10.1
43 hematopoietic stem cell transplantation 10.1
44 epilepsy 10.1
45 glioblastoma multiforme 10.1
46 rhabdomyosarcoma 10.1
47 histiocytosis 10.1
48 bladder carcinoma in situ 10.1 CDKN2A TP53
49 vulva squamous cell carcinoma 10.1 CDKN2A TP53
50 acral lentiginous melanoma 10.1 BRAF CDKN2A

Graphical network of the top 20 diseases related to Spitz Nevus:



Diseases related to Spitz Nevus

Symptoms & Phenotypes for Spitz Nevus

MGI Mouse Phenotypes related to Spitz Nevus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 BRAF CDKN2A HRAS TP53
2 no phenotypic analysis MP:0003012 8.92 CDKN2A HRAS MKI67 TP53

Drugs & Therapeutics for Spitz Nevus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Artificial Intelligence-assisted Evaluation of Pigmented Skin Lesions Recruiting NCT03362138

Search NIH Clinical Center for Spitz Nevus

Genetic Tests for Spitz Nevus

Anatomical Context for Spitz Nevus

MalaCards organs/tissues related to Spitz Nevus:

41
Skin, Tongue, Lung, Brain, Pancreas, Cervix, Thyroid

Publications for Spitz Nevus

Articles related to Spitz Nevus:

(show top 50) (show all 158)
# Title Authors Year
1
Angiomatoid and desmoplastic Spitz nevus presenting as a keloidal nodule. ( 29582459 )
2018
2
Acral pigmented Spitz nevus in a child with transepidermal migration of melanocytes: Dermoscopic and reflectance confocal microscopic features. ( 29314193 )
2018
3
Reevaluation of established and new criteria in differential diagnosis of Spitz nevus and melanoma. ( 29417221 )
2018
4
Patient Perspectives: What is a Spitz nevus? ( 30397961 )
2018
5
The diagnosis and management of the Spitz nevus in the pediatric population: a systematic review and meta-analysisA protocol. ( 28407793 )
2017
6
Spitz Nevus Intermingling With Hemangioma, Angiomatoid Spitz Nevus, Angiotropism, and Vascular Co-option Viewed With Differing Availability Heuristics. ( 28398920 )
2017
7
Polypoid Spitz Nevus With a Halo Reaction. ( 28135210 )
2017
8
Genomic Assessment of Blitz Nevi Suggests Classification as a Subset of Blue Nevus Rather Than Spitz Nevus: Clinical, Histopathologic, and Molecular Analysis of 18 Cases. ( 28475519 )
2017
9
Parallel ridge dermoscopic pattern in plantar atypical Spitz nevus. ( 28862772 )
2017
10
THE FAST CLINICAL EVOLUTION OF A SPITZ NEVUS: THREE-YEAR FOLLOW-UP OF A CHILD. ( 28977136 )
2017
11
Agminated Spitz nevus arising in normal skin with redundant HRAS mutation. ( 27694096 )
2016
12
Spitz Nevus: A Rare Lesion of the Oral Cavity. ( 27001333 )
2016
13
A hypopigmented atypical spitz nevus. ( 27176085 )
2016
14
Spitz Nevus Intermingling With a Hemangioma. ( 27043337 )
2016
15
Pediatric pigmented Spitz nevus: A natural course toward involution assessed with dermoscopy. ( 27444090 )
2016
16
Spitz nevus on the palm with crista transverse dots/dotted lines revealed by dermoscopic examination. ( 25807954 )
2015
17
Ulcerated Spitz nevus masquerading as a juvenile xanthogranuloma. ( 25441121 )
2015
18
Dermoscopy of pigmented variant of acral Spitz nevus. ( 25500025 )
2015
19
Recurrent Spitz nevus with multiple satellite lesions on perineum. ( 25566925 )
2015
20
Pigmented Spitz nevus simulating a solitary angiokeratoma. ( 25773434 )
2015
21
Spitz Nevus on the Perianal Area of a Child: An Unusual Location. ( 26719661 )
2015
22
Agminated spitz nevus on sole of elderly. ( 25814764 )
2015
23
Balloon-cell variant of the Spitz nevus. ( 26147249 )
2015
24
Spitz Nevus Arising in the Eyelid of a Teenager. ( 26498574 )
2015
25
Spitz nevus on the sole of the foot presenting with transepidermal elimination. ( 24855573 )
2014
26
Lipoblastoid/signet-ring cell-rich Spitz nevus: a hitherto unreported microscopic variant. ( 24977308 )
2014
27
Desmoplastic Spitz Nevus Combined With Cutaneous Leiomyoma: A Rare Collision Tumor. ( 25171428 )
2014
28
An atypical variant of phacomatosis pigmentokeratotica: verrucous epidermal nevus, speckled lentiginous nevus, and Spitz nevus associated with scoliosis. ( 24877171 )
2014
29
Congenital Spitz nevus on the foot. ( 24506180 )
2014
30
Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview. ( 24075547 )
2013
31
Neuropilin-2 as a useful marker in the differentiation between Spitzoid malignant melanoma and Spitz nevus. ( 22954749 )
2013
32
Intraoral Spitz nevus: case report and literature review. ( 24139994 )
2013
33
Verrucous spitz nevus in a Japanese female. ( 24348378 )
2013
34
Solitary spindle cell xanthogranuloma mimicking a spitz nevus. ( 24257193 )
2013
35
Compound clear cell sarcoma misdiagnosed as a Spitz nevus. ( 23980901 )
2013
36
Spitz nevus arising upon a congenital glomuvenous malformation. ( 22304367 )
2013
37
Pseudogranulomatous Spitz nevus: a variant of Spitz nevus with heavy inflammatory infiltrate mimicking a granulomatous dermatitis. ( 22985334 )
2013
38
Inflammatory changes with features of chronic leukocytoclastic vasculitis in a Spitz nevus. ( 24033918 )
2013
39
Characteristics of spitzoid melanoma and clues for differential diagnosis with spitz nevus. ( 22257900 )
2012
40
What is your diagnosis? Desmoplastic Spitz nevus. ( 22439303 )
2012
41
Spitz nevus and Reed nevus. ( 22714748 )
2012
42
Dermoscopic findings of pigmented Spitz nevus of the sole. ( 22779696 )
2012
43
HRAS-mutated Spitz nevus on the cheek in a middle-aged man. ( 22113246 )
2012
44
Spitz nevus with Homer-Wright rosette-like structures. ( 22356919 )
2012
45
Desmoplastic nevus: An entity distinct from spitz nevus and blue nevus. ( 21124206 )
2011
46
Dermatoscopy of an angiomatoid spitz nevus. ( 21712688 )
2011
47
Acral pigmented spitz nevus that clinically mimicked acral lentiginous malignant melanoma. ( 21747632 )
2011
48
Polypoid Spitz nevus: two cases evaluated with genetic technique, prolonged follow up, and sentinel lymph node biopsy. ( 21645037 )
2011
49
Spitz nevus and atypical spitzoid neoplasm. ( 21051010 )
2010
50
Spitz nevus in a Hispanic population: a clinicopathological study of 130 cases. ( 20098300 )
2010

Variations for Spitz Nevus

Expression for Spitz Nevus

Search GEO for disease gene expression data for Spitz Nevus.

Pathways for Spitz Nevus

Pathways related to Spitz Nevus according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1 12.53 BRAF HRAS TP53
2
Show member pathways
12.5 BRAF CDKN2A HRAS TP53
3
Show member pathways
12.47 BRAF HRAS TP53
4
Show member pathways
12.44 BRAF HRAS TP53
5 12.43 BRAF CDKN2A HRAS TP53
6
Show member pathways
12.3 BRAF HRAS TP53
7
Show member pathways
12.29 BRAF CDKN2A HRAS TP53
8 12.28 CDKN2A HRAS TP53
9 12.27 CDKN2A MKI67 TP53
10
Show member pathways
12.26 BRAF HRAS TP53
11
Show member pathways
12.23 BRAF HRAS TP53
12
Show member pathways
12.22 BRAF CDKN2A HRAS TP53
13
Show member pathways
12.17 BRAF CDKN2A HRAS
14 12.16 CDKN2A HRAS TP53
15 12.02 BRAF HRAS TP53
16
Show member pathways
12 BRAF HRAS TP53
17 12 CDKN2A HRAS TP53
18
Show member pathways
11.95 BRAF HRAS TP53
19 11.89 CDKN2A HRAS TP53
20
Show member pathways
11.88 BRAF HRAS TP53
21
Show member pathways
11.84 BRAF HRAS TP53
22 11.73 BRAF HRAS TP53
23 11.6 CDKN2A HRAS TP53
24 11.51 BRAF HRAS
25 11.5 HRAS TP53
26 11.5 BRAF CDKN2A HRAS TP53
27 11.49 HRAS TP53
28 11.48 HRAS TP53
29
Show member pathways
11.48 BRAF HRAS
30 11.43 BRAF HRAS
31 11.38 CDKN2A TP53
32 11.35 CDKN2A TP53
33 11.29 HRAS TP53
34 11.28 BRAF CDKN2A HRAS TP53
35 11.26 BRAF HRAS
36 11.14 BRAF HRAS
37 11.1 CDKN2A TP53
38 10.9 CDKN2A TP53
39
Show member pathways
10.89 CDKN2A TP53
40 10.79 BRAF CDKN2A HRAS TP53

GO Terms for Spitz Nevus

Biological processes related to Spitz Nevus according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.65 CDKN2A HRAS TP53
2 cell proliferation GO:0008283 9.63 HRAS MKI67 TP53
3 cellular response to drug GO:0035690 9.49 BRAF TP53
4 intrinsic apoptotic signaling pathway GO:0097193 9.43 HRAS TP53
5 cell aging GO:0007569 9.4 HRAS TP53
6 cellular response to gamma radiation GO:0071480 9.37 HRAS TP53
7 cell cycle arrest GO:0007050 9.33 CDKN2A HRAS TP53
8 cellular senescence GO:0090398 9.32 CDKN2A HRAS
9 replicative senescence GO:0090399 9.26 CDKN2A TP53
10 positive regulation of gene expression GO:0010628 9.26 BRAF CDKN2A HRAS TP53
11 Ras protein signal transduction GO:0007265 8.8 CDKN2A HRAS TP53

Molecular functions related to Spitz Nevus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Spitz Nevus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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