MCID: SPT022
MIFTS: 32

Spitzoid Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Spitzoid Melanoma

MalaCards integrated aliases for Spitzoid Melanoma:

Name: Spitzoid Melanoma 12
Atypical Spitz Nevus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070326
NCIt 51 C136825

Summaries for Spitzoid Melanoma

Disease Ontology : 12 A skin melanoma that is characterized by asymmetric shape, diameter greater than 1 cm, a lesion with a deep invasive component, and a high degree of cytologic atypia.

MalaCards based summary : Spitzoid Melanoma, also known as atypical spitz nevus, is related to spitz nevus and melanoma. An important gene associated with Spitzoid Melanoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are MAPK-Erk Pathway and MAPK signaling pathway. Affiliated tissues include skin, thyroid and lymph node, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Spitzoid Melanoma

Diseases related to Spitzoid Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 spitz nevus 30.5 BRAF HRAS
2 melanoma 10.9
3 li-fraumeni syndrome 10.1
4 li-fraumeni syndrome 2 10.1
5 burn scar 10.1
6 melanoma in congenital melanocytic nevus 10.1
7 neurofibroma 10.1
8 leopard syndrome 9.9 BRAF HRAS
9 pulmonic stenosis 9.9 BRAF HRAS
10 cardiofaciocutaneous syndrome 1 9.9 BRAF HRAS
11 ovarian serous cystadenocarcinoma 9.9 BRAF HRAS
12 adenocarcinoma 9.9 BRAF HRAS
13 leukemia, chronic lymphocytic 9.9 BRAF HRAS
14 leukemia, chronic lymphocytic 2 9.9 BRAF HRAS
15 colorectal adenocarcinoma 9.9 BRAF HRAS
16 testicular germ cell tumor 9.9 BRAF HRAS
17 differentiated thyroid carcinoma 9.9 BRAF HRAS
18 renal cell carcinoma, papillary, 1 9.9 BRAF HRAS
19 suppression of tumorigenicity 12 9.9 BRAF HRAS
20 transitional cell carcinoma 9.8 BRAF HRAS
21 thyroid cancer 9.8 BRAF HRAS
22 thyroid cancer, nonmedullary, 2 9.8 BRAF HRAS
23 melanoma, cutaneous malignant 1 9.8 BRAF HRAS
24 bladder urothelial carcinoma 9.8 BRAF HRAS
25 lung squamous cell carcinoma 9.8 BRAF HRAS
26 squamous cell carcinoma 9.8 BRAF HRAS
27 myeloma, multiple 9.8 BRAF HRAS
28 noonan syndrome 1 9.8 BRAF HRAS
29 squamous cell carcinoma, head and neck 9.8 BRAF HRAS
30 large intestine cancer 9.7 BRAF HRAS
31 brain cancer 9.7 BRAF HRAS
32 gastric adenocarcinoma 9.7 BRAF HRAS
33 glioblastoma 9.7 BRAF HRAS
34 lung cancer susceptibility 3 9.6 BRAF HRAS
35 sarcoma 9.5 BRAF HRAS

Graphical network of the top 20 diseases related to Spitzoid Melanoma:



Diseases related to Spitzoid Melanoma

Symptoms & Phenotypes for Spitzoid Melanoma

GenomeRNAi Phenotypes related to Spitzoid Melanoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.65 BRAF HRAS
2 Decreased viability GR00221-A-1 9.65 HRAS
3 Decreased viability GR00221-A-2 9.65 HRAS
4 Decreased viability GR00221-A-3 9.65 HRAS
5 Decreased viability GR00221-A-4 9.65 BRAF
6 Decreased viability GR00301-A 9.65 BRAF
7 Decreased viability GR00381-A-1 9.65 BRAF
8 Decreased viability GR00402-S-2 9.65 BRAF HRAS
9 Decreased cell migration GR00055-A-1 9.16 BRAF HRAS
10 Increased cell migration GR00055-A-3 8.62 BRAF HRAS

Drugs & Therapeutics for Spitzoid Melanoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Molecular Analysis of Childhood and Adolescent Melanocytic Lesions Recruiting NCT02775643

Search NIH Clinical Center for Spitzoid Melanoma

Genetic Tests for Spitzoid Melanoma

Anatomical Context for Spitzoid Melanoma

MalaCards organs/tissues related to Spitzoid Melanoma:

42
Skin, Thyroid, Lymph Node, Brain

Publications for Spitzoid Melanoma

Articles related to Spitzoid Melanoma:

(show all 40)
# Title Authors Year
1
Potentially Actionable MAP3K8 Alterations Are Common in Spitzoid Melanoma. ( 30877083 )
2019
2
Spitzoid melanoma with histopathological features of ALK gene rearrangement exhibiting ALK copy number gain: a novel mechanism of ALK activation in spitzoid neoplasia. ( 29897634 )
2019
3
Parallel ridge dermoscopic pattern in plantar atypical Spitz nevus. ( 28862772 )
2018
4
Agminated Spitz naevi or metastatic spitzoid melanoma? ( 29405264 )
2018
5
A hypopigmented atypical spitz nevus. ( 27176085 )
2016
6
The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing. ( 26892443 )
2016
7
Hypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update. ( 25692081 )
2015
8
A case of spitzoid melanoma. ( 25834363 )
2015
9
A Pediatric Case of Spitzoid Melanoma with Subsequent Large Lymph Node Metastasis. ( 26082599 )
2015
10
Spitzoid melanoma of childhood: a case series and review. ( 30190841 )
2015
11
Spitzoid melanoma in a child with Li-Fraumeni syndrome. ( 24251760 )
2014
12
Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview. ( 24075547 )
2013
13
Spitzoid and non-spitzoid melanoma in children: a prognostic comparative study. ( 22928628 )
2013
14
Intratumoral heterogeneity of chromosome 9 loss and CDKN2A (p16) protein expression in a morphologically challenging spitzoid melanoma. ( 23221484 )
2013
15
Characteristics of spitzoid melanoma and clues for differential diagnosis with spitz nevus. ( 22257900 )
2012
16
A case of spitzoid melanoma with lymph node metastasis in a child. ( 22468113 )
2012
17
Fluorescence in situ hybridization for the differential diagnosis between Spitz naevus and spitzoid melanoma. ( 22882594 )
2012
18
Expression of p16 alone does not differentiate between Spitz nevi and Spitzoid melanoma. ( 23005921 )
2012
19
What is your diagnosis? Spitzoid melanoma. ( 23259204 )
2012
20
Spitzoid melanoma and micrometastases in two lymph node regions: a critical situation. ( 21489908 )
2011
21
Spitz nevi, atypical spitzoid neoplasms, and spitzoid melanoma. ( 21549244 )
2011
22
Erratum: Cutaneous Spitzoid melanoma in a very young girl of Asian descent. ( 22110563 )
2011
23
Cutaneous Spitzoid melanoma in a very young girl of Asian descent. ( 22700484 )
2011
24
Spitzoid melanoma: dermoscopic report and diagnostic discussion. ( 21251441 )
2010
25
Spitzoid melanoma in children: clinicopathological study and application of immunohistochemistry as an adjunct diagnostic tool. ( 19032380 )
2009
26
Spitzoid melanoma. ( 19880042 )
2009
27
Spitz Nevi, Atypical Spitzoid Neoplasms, and Spitzoid Melanoma. ( 26838535 )
2009
28
Amelanotic spitzoid melanoma in a prepubescent boy. ( 17437116 )
2008
29
Spitz nevus versus spitzoid melanoma: diagnostic difficulties, conceptual controversies. ( 16858148 )
2006
30
Are all melanomas the same? Spitzoid melanoma is a distinct subtype of melanoma. ( 16421887 )
2006
31
Spitzoid melanoma in childhood. ( 16709493 )
2006
32
Positive sentinel node biopsy in a 30-month-old boy with atypical Spitz tumour (Spitzoid melanoma). ( 16722946 )
2006
33
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma. ( 16096402 )
2005
34
Synchronously diagnosed pre-sacral neurofibroma and cutaneous spitzoid melanoma: a fortuitous association? ( 15363097 )
2004
35
Genetic similarities between Spitz nevus and Spitzoid melanoma in children. ( 15503312 )
2004
36
Spitz naevus versus Spitzoid melanoma: when and how can they be distinguished? ( 11902448 )
2002
37
A current dilemma in histopathology: atypical spitz tumor or Spitzoid melanoma? ( 11994167 )
2002
38
Atypical spitz nevus/tumor. ( 10667434 )
1999
39
Cytogenetics of an atypical Spitz nevus metastatic to a single lymph node. ( 9566288 )
1998
40
Amelanotic Spitzoid melanoma in the burn scar of a child. ( 8844745 )
1996

Variations for Spitzoid Melanoma

Expression for Spitzoid Melanoma

Search GEO for disease gene expression data for Spitzoid Melanoma.

Pathways for Spitzoid Melanoma

Pathways related to Spitzoid Melanoma according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 BRAF HRAS
2 12.36 BRAF HRAS
3
Show member pathways
12.36 BRAF HRAS
4
Show member pathways
12.34 BRAF HRAS
5
Show member pathways
12.33 BRAF HRAS
6
Show member pathways
12.31 BRAF HRAS
7
Show member pathways
12.29 BRAF HRAS
8
Show member pathways
12.28 BRAF HRAS
9
Show member pathways
12.26 BRAF HRAS
10 12.23 BRAF HRAS
11
Show member pathways
12.21 BRAF HRAS
12
Show member pathways
12.15 BRAF HRAS
13
Show member pathways
12.13 BRAF HRAS
14
Show member pathways
12.12 BRAF HRAS
15
Show member pathways
12.04 BRAF HRAS
16
Show member pathways
12.02 BRAF HRAS
17
Show member pathways
12 BRAF HRAS
18
Show member pathways
11.99 BRAF HRAS
19
Show member pathways
11.95 BRAF HRAS
20
Show member pathways
11.91 BRAF HRAS
21 11.9 BRAF HRAS
22
Show member pathways
11.88 BRAF HRAS
23
Show member pathways
11.87 BRAF HRAS
24
Show member pathways
11.85 BRAF HRAS
25
Show member pathways
11.82 BRAF HRAS
26
Show member pathways
11.8 BRAF HRAS
27 11.78 BRAF HRAS
28
Show member pathways
11.76 BRAF HRAS
29
Show member pathways
11.73 BRAF HRAS
30
Show member pathways
11.68 BRAF HRAS
31
Show member pathways
11.66 BRAF HRAS
32
Show member pathways
11.6 BRAF HRAS
33 11.56 BRAF HRAS
34 11.53 BRAF HRAS
35 11.5 BRAF HRAS
36 11.46 BRAF HRAS
37 11.35 BRAF HRAS
38
Show member pathways
11.32 BRAF HRAS
39 11.23 BRAF HRAS
40 11.15 BRAF HRAS
41
Show member pathways
11.07 BRAF HRAS
42 11.02 BRAF HRAS
43 10.93 BRAF HRAS
44 10.59 BRAF HRAS
45 10.15 BRAF HRAS

GO Terms for Spitzoid Melanoma

Biological processes related to Spitzoid Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.4 BRAF HRAS
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.37 BRAF HRAS
3 MAPK cascade GO:0000165 9.32 BRAF HRAS
4 negative regulation of neuron apoptotic process GO:0043524 9.26 BRAF HRAS
5 T cell receptor signaling pathway GO:0050852 9.16 BRAF HRAS
6 animal organ morphogenesis GO:0009887 8.96 BRAF HRAS
7 protein heterooligomerization GO:0051291 8.62 BRAF HRAS

Molecular functions related to Spitzoid Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 8.62 BRAF HRAS

Sources for Spitzoid Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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