MCID: SPL001
MIFTS: 23

Spleen Angiosarcoma

Categories: Cancer diseases, Cardiovascular diseases, Immune diseases

Aliases & Classifications for Spleen Angiosarcoma

MalaCards integrated aliases for Spleen Angiosarcoma:

Name: Spleen Angiosarcoma 12 15
Angiosarcoma of Spleen 12 70
Splenic Hemangiosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:265
NCIt 50 C4564
SNOMED-CT 67 187821001
UMLS 70 C0346424

Summaries for Spleen Angiosarcoma

Disease Ontology : 12 An angiosarcoma and hemangioma of intra-abdominal structure and malignant soft tissue neoplasm of the spleen that results in a nonhematolymphoid malignant neoplasm of the spleen.

MalaCards based summary : Spleen Angiosarcoma, also known as angiosarcoma of spleen, is related to angiosarcoma and portal hypertension. An important gene associated with Spleen Angiosarcoma is CD320 (CD320 Molecule), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Diseases of metabolism. Affiliated tissues include spleen and thyroid.

Related Diseases for Spleen Angiosarcoma

Diseases related to Spleen Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 10.0
2 portal hypertension 9.9
3 disseminated intravascular coagulation 9.9
4 thrombocytopenia 9.9
5 vascular disease 9.9
6 leiomyosarcoma 9.9
7 adenocarcinoma 9.9
8 gastric adenocarcinoma 9.9
9 polycythemia 9.9
10 splenomegaly 9.9
11 thyroid carcinoma 9.9
12 hemangioma 9.9
13 anal gland adenocarcinoma 9.8 TCN2 CD320
14 anus adenocarcinoma 9.8 TCN2 CD320
15 vitamin metabolic disorder 9.8 TCN2 CD320
16 vitamin b12 deficiency 9.8 TCN2 CD320
17 omphalocele 9.7 TCN2 CD320
18 methylmalonic acidemia 9.7 TCN2 CD320
19 megaloblastic anemia 9.6 TCN2 CD320

Graphical network of the top 20 diseases related to Spleen Angiosarcoma:



Diseases related to Spleen Angiosarcoma

Symptoms & Phenotypes for Spleen Angiosarcoma

Drugs & Therapeutics for Spleen Angiosarcoma

Search Clinical Trials , NIH Clinical Center for Spleen Angiosarcoma

Genetic Tests for Spleen Angiosarcoma

Anatomical Context for Spleen Angiosarcoma

MalaCards organs/tissues related to Spleen Angiosarcoma:

40
Spleen, Thyroid

Publications for Spleen Angiosarcoma

Articles related to Spleen Angiosarcoma:

(show all 11)
# Title Authors PMID Year
1
Primary Spleen Angiosarcoma With Concomitant Hepatic Hemangiomas on 18F-FDG PET/CT. 61
29356748 2018
2
Adjuvant Radiochemotherapy with a 23-Month Overall Survival Time in a Patient after a Surgery due to Splenic Hemangiosarcoma Rupture: A Case Report with the Literature Review. 61
29607237 2018
3
Primary Epithelioid Angiosarcoma of Spleen: A Case Report and Review of Literature. 61
26894076 2016
4
Well-differentiated angiosarcoma of spleen: a teaching case mimicking hemagioma and cytogenetic analysis with array comparative genomic hybridization. 61
26462621 2015
5
Spontaneous rupture of primary splenic angiosarcoma: a case report and literature review. 61
23497454 2013
6
Angiosarcoma of the proximal humerus: a case report and review of the literature. 61
23050518 2012
7
[Spontaneous spleen rupture due to primary splenic angiosarcoma: a case report]. 61
17978914 2007
8
[The clinical application of splenectomy in pyrexia of unknown origin with splenomegaly]. 61
15840216 2005
9
[Primary angiosarcoma of the spleen]. 61
8357650 1993
10
MRI of primary spleen angiosarcoma with iron accumulation. 61
1545029 1992
11
Functional asplenia and uptake of bone imaging agent in angiosarcoma of spleen. 61
3161680 1985

Variations for Spleen Angiosarcoma

Expression for Spleen Angiosarcoma

Search GEO for disease gene expression data for Spleen Angiosarcoma.

Pathways for Spleen Angiosarcoma

Pathways related to Spleen Angiosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.74 TCN2 CD320 AKR1C1
2
Show member pathways
11.12 TCN2 CD320
3 9.95 TCN2 CD320

GO Terms for Spleen Angiosarcoma

Biological processes related to Spleen Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.56 MIR758 MIR505 MIR452 MIR33B
2 cholesterol homeostasis GO:0042632 9.32 MIR33B AKR1C1
3 negative regulation of cholesterol efflux GO:0090370 9.16 MIR758 MIR33B
4 cobalamin metabolic process GO:0009235 8.96 TCN2 CD320
5 cobalamin transport GO:0015889 8.62 TCN2 CD320

Molecular functions related to Spleen Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cobalamin binding GO:0031419 8.62 TCN2 CD320

Sources for Spleen Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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