MCID: SPL001
MIFTS: 26

Spleen Angiosarcoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Spleen Angiosarcoma

MalaCards integrated aliases for Spleen Angiosarcoma:

Name: Spleen Angiosarcoma 12 15
Angiosarcoma of Spleen 12 74
Splenic Hemangiosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:265
NCIt 51 C4564
UMLS 74 C0346424

Summaries for Spleen Angiosarcoma

Disease Ontology : 12 An angiosarcoma and hemangioma of intra-abdominal structure and malignant soft tissue neoplasm of the spleen that results in a nonhematolymphoid malignant neoplasm of the spleen.

MalaCards based summary : Spleen Angiosarcoma, also known as angiosarcoma of spleen, is related to angiosarcoma and hepatocellular carcinoma. An important gene associated with Spleen Angiosarcoma is CYP51A1 (Cytochrome P450 Family 51 Subfamily A Member 1), and among its related pathways/superpathways are ECM-receptor interaction and Cell adhesion molecules (CAMs). Affiliated tissues include spleen, bone and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spleen Angiosarcoma

Diseases related to Spleen Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 30.2 PECAM1 VWF
2 hepatocellular carcinoma 10.0
3 portal hypertension 10.0
4 leiomyosarcoma 10.0
5 adenocarcinoma 10.0
6 gastric adenocarcinoma 10.0
7 polycythemia 10.0
8 spleen cancer 9.8 CD34 CYP51A1
9 erythema elevatum diutinum 9.8 CD34 PECAM1
10 hemangioma 9.7 CD34 PECAM1
11 deep angioma 9.7 CD34 VWF
12 intramuscular hemangioma 9.7 CD34 VWF
13 liver angiosarcoma 9.7 CD34 VWF
14 lymphangiosarcoma 9.6 CD34 VWF
15 vascular cancer 9.6 CD34 VWF
16 kaposiform hemangioendothelioma 9.5 CD34 PECAM1 VWF
17 bone marrow cancer 9.4 CD34 VWF

Graphical network of the top 20 diseases related to Spleen Angiosarcoma:



Diseases related to Spleen Angiosarcoma

Symptoms & Phenotypes for Spleen Angiosarcoma

GenomeRNAi Phenotypes related to Spleen Angiosarcoma according to GeneCards Suite gene sharing:

27 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.53 PECAM1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.53 PECAM1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.53 PECAM1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.53 PECAM1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.53 PECAM1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.53 CYP51A1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.53 PECAM1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.53 PECAM1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.53 CYP51A1 PECAM1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.53 CYP51A1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.53 PECAM1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.53 PECAM1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.53 CYP51A1 PECAM1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.53 CYP51A1

MGI Mouse Phenotypes related to Spleen Angiosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 CD34 CYP51A1 PECAM1 SPON1 VWF

Drugs & Therapeutics for Spleen Angiosarcoma

Search Clinical Trials , NIH Clinical Center for Spleen Angiosarcoma

Genetic Tests for Spleen Angiosarcoma

Anatomical Context for Spleen Angiosarcoma

MalaCards organs/tissues related to Spleen Angiosarcoma:

42
Spleen, Bone, Liver, Bone Marrow

Publications for Spleen Angiosarcoma

Articles related to Spleen Angiosarcoma:

# Title Authors Year
1
Primary Spleen Angiosarcoma With Concomitant Hepatic Hemangiomas on 18F-FDG PET/CT. ( 29356748 )
2018
2
Primary Epithelioid Angiosarcoma of Spleen: A Case Report and Review of Literature. ( 26894076 )
2016
3
Well-differentiated angiosarcoma of spleen: a teaching case mimicking hemagioma and cytogenetic analysis with array comparative genomic hybridization. ( 26462621 )
2015
4
MRI of primary spleen angiosarcoma with iron accumulation. ( 1545029 )
1992
5
Functional asplenia and uptake of bone imaging agent in angiosarcoma of spleen. ( 3161680 )
1985

Variations for Spleen Angiosarcoma

Expression for Spleen Angiosarcoma

Search GEO for disease gene expression data for Spleen Angiosarcoma.

Pathways for Spleen Angiosarcoma

Pathways related to Spleen Angiosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.34 PECAM1 VWF
2 11.12 CD34 PECAM1
3 10.57 PECAM1 VWF

GO Terms for Spleen Angiosarcoma

Cellular components related to Spleen Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 CD34 PECAM1

Biological processes related to Spleen Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.32 PECAM1 VWF
2 leukocyte migration GO:0050900 9.26 CD34 PECAM1
3 cell adhesion GO:0007155 9.26 CD34 PECAM1 SPON1 VWF
4 platelet degranulation GO:0002576 9.16 PECAM1 VWF
5 glomerular endothelium development GO:0072011 8.62 CD34 PECAM1

Molecular functions related to Spleen Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.62 SPON1 VWF

Sources for Spleen Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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