MCID: SPL011
MIFTS: 33

Spleen Cancer

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Spleen Cancer

MalaCards integrated aliases for Spleen Cancer:

Name: Spleen Cancer 12 20 15 17
Spleen Neoplasm 12 73 20
Splenic Neoplasms 44 70
Splenic Neoplasm 12 20
Malignant Neoplasm of Spleen 70
Malignant Tumour of Spleen 12
Malignant Splenic Tumor 12
Tumor of Spleen 20

Classifications:



External Ids:

Disease Ontology 12 DOID:672
MeSH 44 D013160
NCIt 50 C3383 C3539
SNOMED-CT 67 127230005 94071006
ICD10 32 C26.1
UMLS 70 C0037999 C0153470

Summaries for Spleen Cancer

Disease Ontology : 12 A lymphatic system cancer that affects white blood cells and involves tumor deposits in the spleen.

MalaCards based summary : Spleen Cancer, also known as spleen neoplasm, is related to thyrotoxic exophthalmos and endocrine exophthalmos. An important gene associated with Spleen Cancer is IGHV4-38-2 (Immunoglobulin Heavy Variable 4-38-2), and among its related pathways/superpathways are Innate Immune System and Downstream signaling events of B Cell Receptor (BCR). Affiliated tissues include spleen and lymph node, and related phenotypes are Decreased replication of vaccinia virus (VACV) and hematopoietic system

Wikipedia : 73 The spleen is an organ found in all vertebrates. Similar in structure to a large lymph node, it acts... more...

Related Diseases for Spleen Cancer

Diseases related to Spleen Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 thyrotoxic exophthalmos 10.4 MME CD5
2 endocrine exophthalmos 10.4 MME CD5
3 b cell prolymphocytic leukemia 10.4 CD5 CD19
4 hilar lung carcinoma 10.4 MME CD79A
5 lung hilum cancer 10.4 MME CD79A
6 gamma heavy chain disease 10.4 MYD88 IGHV4-38-2
7 heart lymphoma 10.4 MME BCL6
8 ovarian lymphoma 10.4 MME BCL6
9 refractory hematologic cancer 10.4 CD22 CD19
10 refractory hairy cell leukemia 10.4 CD22 CD19
11 liver lymphoma 10.4 MME CD79A
12 central nervous system leukemia 10.3 MME CD19
13 t-cell/histiocyte rich large b cell lymphoma 10.3 MME BCL6
14 mental retardation, autosomal dominant 10 10.3 IGHV4-38-2 CD22
15 invasive malignant thymoma 10.3 MME CD19
16 agammaglobulinemia, non-bruton type 10.3 CD79B CD79A
17 hodgkin's lymphoma, nodular sclerosis 10.3 CD79A BCL6
18 anemia, autoimmune hemolytic 10.3 IGHV4-38-2 CD5 CD19
19 mental retardation, autosomal dominant 33 10.3 MME IGHV4-38-2 CD22
20 lymphosarcoma 10.3 CD22 BCL6
21 ureteral lymphoma 10.3 MME CD5 BCL6
22 chest wall lymphoma 10.3 MME IGHV4-38-2 BCL6
23 prostate lymphoma 10.3 MME CD5 BCL6
24 appendix lymphoma 10.3 MME CD5 BCL6
25 monoclonal paraproteinemia 10.3 IGHV4-38-2 CD79A CD19
26 sclerosing hepatic carcinoma 10.3 MME CD79A CD5
27 soft palate cancer 10.3 CD22 BCL6
28 mediastinal cancer 10.3 CD79A CD5
29 immunodeficiency with hyper-igm, type 1 10.3 IGHV4-38-2 CD79A CD19
30 cerebral lymphoma 10.3 MME CD79A CD19
31 paranasal sinus lymphoma 10.3 MME CD79A BCL6
32 primary central nervous system lymphoma 10.3 MYD88 BCL6
33 heavy chain disease 10.3 MYD88 IGHV4-38-2 CD79A
34 lymphoblastic lymphoma 10.3 MME CD5 BCL6
35 gray zone lymphoma 10.3 MME CD79A BCL6
36 relapsed/refractory diffuse large b-cell lymphoma 10.3 CD79B CD22 CD19
37 kidney cortex disease 10.3 U2AF1 MME
38 infected hydrocele 10.2 SPN CD79A
39 intrahepatic bile duct adenoma 10.2 NOTCH2 MME
40 nasal cavity lymphoma 10.2 MME IGHV4-38-2 CD5 BCL6
41 pleural empyema 10.2 CD79A BCL6
42 agammaglobulinemia, x-linked 10.2 CD79B CD79A CD19
43 agammaglobulinemia 10.2 CD79B CD79A CD19
44 plasmacytoma 10.2 CD79B CD79A CD5
45 orofaciodigital syndrome viii 10.2 IGHV4-38-2 BIRC3 BCL6
46 monoclonal gammopathy of uncertain significance 10.2 U2AF1 MYD88 IGHV4-38-2 CD19
47 epiglottis neoplasm 10.2 MME CD79A CD5 BCL6
48 silo filler's disease 10.2 MYD88 ITGAX
49 pediatric lymphoma 10.2 MME IGHV4-38-2 CD79A BCL6
50 colon lymphoma 10.2 MME CD79A CD5 BCL6

Graphical network of the top 20 diseases related to Spleen Cancer:



Diseases related to Spleen Cancer

Symptoms & Phenotypes for Spleen Cancer

GenomeRNAi Phenotypes related to Spleen Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased replication of vaccinia virus (VACV) GR00362-A 8.32 KLF2

MGI Mouse Phenotypes related to Spleen Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 BCL6 BIRC3 CARD11 CD19 CD22 CD5
2 immune system MP:0005387 10.21 BCL6 BIRC3 CARD11 CD19 CD22 CD5
3 cellular MP:0005384 10.11 BCL6 BIRC3 CARD11 CD19 CD22 CD79A
4 liver/biliary system MP:0005370 9.85 BCL6 CD19 CD79A KLF2 MME MYD88
5 no phenotypic analysis MP:0003012 9.65 BCL6 CD5 CD79A CD79B ITGAX KLF2
6 normal MP:0002873 9.28 BCL6 BIRC3 CD19 CD5 CD79A CD79B

Drugs & Therapeutics for Spleen Cancer

Search Clinical Trials , NIH Clinical Center for Spleen Cancer

Cochrane evidence based reviews: splenic neoplasms

Genetic Tests for Spleen Cancer

Anatomical Context for Spleen Cancer

MalaCards organs/tissues related to Spleen Cancer:

40
Spleen, Lymph Node

Publications for Spleen Cancer

Articles related to Spleen Cancer:

# Title Authors PMID Year
1
Abdominal collateral vein as an unconventional vascular access for hemodialysis in patient with central vein occlusion. 61
24796505 2014
2
Correlation between urokinase-type plasminogen activator production and the metastatic ability of human rectal cancer cells. 61
1765431 1991
3
[Report on nationwide pooled data and cohort investigation in UFT phase II study]. 61
3115185 1987

Variations for Spleen Cancer

Expression for Spleen Cancer

Search GEO for disease gene expression data for Spleen Cancer.

Pathways for Spleen Cancer

Pathways related to Spleen Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 TRAF3 TNFAIP3 MYD88 MME ITGAX CD79B
2
Show member pathways
12.55 CD79B CD79A CD22 CD19 CARD11
3
Show member pathways
12.41 CD79B CD79A CD22 CD19 BCL6
4
Show member pathways
12.38 TRAF3 TNFAIP3 MYD88 BIRC3
5
Show member pathways
12.25 CD22 CD19 CARD11 BCL6
6 12.21 TRAF3 TNFAIP3 MYD88 CD79A CD19 CARD11
7
Show member pathways
12.19 CD79B CD79A CD22 CD19 CARD11 BCL6
8 12.05 TRAF3 TNFAIP3 MYD88 BIRC3
9 11.76 TRAF3 TNFAIP3 BIRC3
10
Show member pathways
11.73 CD79B CD79A CD22 CD19
11 11.67 TRAF3 TNFAIP3 MYD88 CARD11 BIRC3
12 11.66 MME CD5 CD22 CD19
13 11.34 SPN NOTCH2 MME ITGAX CD79B CD79A
14 11.22 SPN MME ITGAX ITGAE CD19
15 11.09 TRAF3 TNFAIP3 BIRC3

GO Terms for Spleen Cancer

Cellular components related to Spleen Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.15 SPN NOTCH2 MYD88 MME ITGAX ITGAE
2 integral component of plasma membrane GO:0005887 9.8 SPN NOTCH2 MME CD79B CD5 CD22
3 cell surface GO:0009986 9.72 SPN NOTCH2 MME ITGAX CD22
4 membrane raft GO:0045121 9.35 MME CD79A CD19 CARD11 BIRC3
5 external side of plasma membrane GO:0009897 9.28 SPN ITGAX ITGAE IGHV4-38-2 CD79B CD79A
6 B cell receptor complex GO:0019815 9.16 CD79B CD79A

Biological processes related to Spleen Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.88 TRAF3 MYD88 CD79B CD79A CD19 BCL6
2 regulation of apoptotic process GO:0042981 9.76 TRAF3 CARD11 BIRC3 BCL6
3 defense response to bacterium GO:0042742 9.73 SPN NOTCH2 MYD88 IGHV4-38-2
4 regulation of inflammatory response GO:0050727 9.65 MYD88 BIRC3 BCL6
5 cell surface receptor signaling pathway GO:0007166 9.65 SPN MYD88 CD79B CD79A BIRC3
6 immunoglobulin mediated immune response GO:0016064 9.49 MYD88 CD19
7 B cell receptor signaling pathway GO:0050853 9.46 IGHV4-38-2 CD79B CD79A CD19
8 Toll signaling pathway GO:0008063 9.37 TRAF3 MYD88
9 regulation of immune response GO:0050776 9.35 SPN CD22 CD19 CARD11 BCL6
10 regulation of germinal center formation GO:0002634 9.32 TNFAIP3 BCL6
11 B cell differentiation GO:0030183 8.92 CD79B CD79A CARD11 BCL6

Sources for Spleen Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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