MCID: SPL011
MIFTS: 30

Spleen Cancer

Categories: Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Spleen Cancer

MalaCards integrated aliases for Spleen Cancer:

Name: Spleen Cancer 12 53 15
Spleen Neoplasm 12 76 53
Splenic Neoplasms 44 73
Splenic Neoplasm 12 53
Malignant Neoplasm of Spleen 73
Malignant Tumour of Spleen 12
Malignant Splenic Tumor 12
Tumor of Spleen 53

Classifications:



External Ids:

Disease Ontology 12 DOID:672
ICD10 33 C26.1
MeSH 44 D013160
NCIt 50 C3383 C3539

Summaries for Spleen Cancer

Disease Ontology : 12 A lymphatic system cancer that affects white blood cells and involves tumor deposits in the spleen.

MalaCards based summary : Spleen Cancer, also known as spleen neoplasm, is related to dendritic cell tumor and pulmonary artery leiomyosarcoma. An important gene associated with Spleen Cancer is CYP51A1 (Cytochrome P450 Family 51 Subfamily A Member 1), and among its related pathways/superpathways are Dendritic Cells Developmental Lineage Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spleen, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Splenic diseases include splenomegaly, where the spleen is enlarged for various reasons. On the other... more...

Related Diseases for Spleen Cancer

Diseases related to Spleen Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 dendritic cell tumor 29.6 CD68 CR2
2 pulmonary artery leiomyosarcoma 10.4 CD68 HBA1
3 interdigitating dendritic cell sarcoma 10.4 CD163 CR2
4 histiocytic and dendritic cell cancer 10.4 CD163 CR2
5 miliaria 10.4 CD68 HBA1
6 chondroid lipoma 10.3 CD68 HBA1
7 rosai-dorfman disease 10.3 CD163 CR2
8 central nervous system sarcoma 10.3 CD163 CD68
9 t-cell/histiocyte rich large b cell lymphoma 10.3 CD68 CR2
10 pneumatosis cystoides intestinalis 10.3 CD68 HBA1
11 lymphoplasmacyte-rich meningioma 10.3 CD163 CD68
12 petroclival meningioma 10.2 CD163 CD68
13 pericardium cancer 10.2 F8 HBA1
14 photokeratitis 10.2 CD163 CD68
15 ovary sarcoma 10.1 CD34 HBA1
16 ovarian angiosarcoma 10.1 CD34 HBA1
17 intravascular fasciitis 10.1 CD34 HBA1
18 thyroid angiosarcoma 10.1 CD34 HBA1
19 neurogenic arthropathy 10.1 CD34 HBA1
20 bone epithelioid hemangioma 10.1 CD34 HBA1
21 langerhans cell sarcoma 10.1 CD163 CR2 HBA1
22 thyroid sarcoma 10.1 CD34 HBA1
23 extraosseous osteosarcoma 10.0 CD34 HBA1
24 breast angiosarcoma 10.0 CD34 HBA1
25 conventional angiosarcoma 10.0 CD34 HBA1
26 enterobiasis 10.0 CD163 CD68
27 lung lymphoma 10.0 CR2 F8
28 venous hemangioma 10.0 CD34 HBA1
29 senile angioma 10.0 CD34 HBA1
30 interstitial emphysema 10.0 CD34 HBA1
31 liver inflammatory pseudotumor 10.0 CD34 CR2
32 angiomyoma 10.0 CD34 HBA1
33 chorioangioma 10.0 CD34 HBA1
34 brain sarcoma 9.9 CD163 CD68 HBA1
35 mesenchymal cell neoplasm 9.9 CD34 HBA1
36 retina lymphoma 9.9 CD34 CD68
37 extracutaneous mastocytoma 9.9 CD34 CD68
38 sternum cancer 9.9 CD34 CD68
39 liver angiosarcoma 9.9 CD34 HBA1
40 melanotic neurilemmoma 9.8 CD34 CD68
41 indeterminate leprosy 9.8 CD68 F8 HBA1
42 diffuse meningeal melanocytosis 9.8 CD34 CD68
43 cardiovascular organ benign neoplasm 9.8 CD34 HBA1
44 sarcomatoid squamous cell skin carcinoma 9.8 CD34 CD68
45 benign perivascular tumor 9.8 CD34 HBA1
46 conventional fibrosarcoma 9.8 CD34 CD68
47 ischemic fasciitis 9.8 CD34 CD68
48 nephrogenic adenofibroma 9.8 CD34 HBA1
49 spleen angiosarcoma 9.8 CD34 CYP51A1 HBA1
50 aleukemic leukemia cutis 9.7 CD34 CD68

Graphical network of the top 20 diseases related to Spleen Cancer:



Diseases related to Spleen Cancer

Symptoms & Phenotypes for Spleen Cancer

MGI Mouse Phenotypes related to Spleen Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CD163 CD34 CD68 CR2 EPX F8
2 immune system MP:0005387 9.17 CD163 CD34 CD68 CR2 CYP51A1 EPX

Drugs & Therapeutics for Spleen Cancer

Search Clinical Trials , NIH Clinical Center for Spleen Cancer

Cochrane evidence based reviews: splenic neoplasms

Genetic Tests for Spleen Cancer

Anatomical Context for Spleen Cancer

MalaCards organs/tissues related to Spleen Cancer:

41
Spleen

Publications for Spleen Cancer

Articles related to Spleen Cancer:

# Title Authors Year
1
Imaging Findings of Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor of Spleen. ( 23751835 )
2013

Variations for Spleen Cancer

Expression for Spleen Cancer

Search GEO for disease gene expression data for Spleen Cancer.

Pathways for Spleen Cancer

Pathways related to Spleen Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 CD163 CD34
2 10.86 CD163 CD34 CD68
3 10.68 CD34 CR2

GO Terms for Spleen Cancer

Cellular components related to Spleen Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 CD163 CD34 CD68 CR2 CYP51A1 EMB

Biological processes related to Spleen Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.16 EPX HBA1
2 acute-phase response GO:0006953 8.96 CD163 F8
3 hydrogen peroxide catabolic process GO:0042744 8.62 EPX HBA1

Molecular functions related to Spleen Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 EPX HBA1
2 heme binding GO:0020037 8.8 CYP51A1 EPX HBA1

Sources for Spleen Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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