Aliases & Classifications for Splenic Abscess

MalaCards integrated aliases for Splenic Abscess:

Name: Splenic Abscess 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2530
ICD10 33 D73.3
NCIt 50 C35347
SNOMED-CT 68 82053000
UMLS 73 C0272412

Summaries for Splenic Abscess

MalaCards based summary : Splenic Abscess is related to endocarditis and infective endocarditis, and has symptoms including hepatosplenomegaly An important gene associated with Splenic Abscess is IER3IP1 (Immediate Early Response 3 Interacting Protein 1). The drugs Meropenem and Ceftazidime have been mentioned in the context of this disorder. Affiliated tissues include spleen, colon and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Splenic Abscess

Diseases related to Splenic Abscess via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 endocarditis 10.4
2 infective endocarditis 10.3
3 peritonitis 10.2
4 melioidosis 10.2
5 cat-scratch disease 10.1
6 brucellosis 10.1
7 typhoid fever 10.1
8 pancreatic cancer 10.0
9 pancreatitis 10.0
10 melancholia 10.0 CRP IER3IP1
11 acute cystitis 10.0 CRP IER3IP1
12 dysentery 10.0 CRP IER3IP1
13 neutrophilic dermatosis, acute febrile 10.0
14 lymphoma 10.0
15 colitis 10.0
16 gastric ulcer 10.0
17 pyelonephritis 10.0
18 sickle cell disease 10.0
19 splenomegaly 10.0
20 glucose metabolism disease 10.0 CRP IER3IP1
21 acquired metabolic disease 9.9 CRP IER3IP1
22 respiratory system disease 9.9 CRP IER3IP1
23 systemic lupus erythematosus 9.9
24 myeloma, multiple 9.9
25 malaria 9.9
26 chronic granulomatous disease 9.9
27 crohn's disease 9.9
28 leukemia 9.9
29 thalassemia 9.9
30 crohn's colitis 9.9
31 osteomyelitis 9.9
32 blastomycosis 9.9
33 purpura 9.9
34 acute pyelonephritis 9.9
35 actinomycosis 9.9
36 lupus erythematosus 9.9
37 nervous system disease 9.8 CRP IER3IP1
38 hepatocellular carcinoma 9.7
39 tetralogy of fallot 9.7
40 thrombocytopenic purpura, autoimmune 9.7
41 polycythemia vera 9.7
42 sickle cell anemia 9.7
43 leukemia, chronic myeloid 9.7
44 aspergillosis 9.7
45 myelodysplastic syndrome 9.7
46 acute leukemia 9.7
47 anaplastic large cell lymphoma 9.7
48 b-cell lymphomas 9.7
49 diabetes mellitus 9.7
50 diffuse large b-cell lymphoma 9.7

Graphical network of the top 20 diseases related to Splenic Abscess:



Diseases related to Splenic Abscess

Symptoms & Phenotypes for Splenic Abscess

UMLS symptoms related to Splenic Abscess:


hepatosplenomegaly

GenomeRNAi Phenotypes related to Splenic Abscess according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.43 CRP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.43 CRP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.43 POU3F4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.43 CRP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.43 CRP POU3F4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.32 POU3F4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.32 CRP POU3F4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.32 CRP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.32 CRP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.32 POU3F4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.32 POU3F4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.32 POU3F4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.32 CRP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.32 CRP

Drugs & Therapeutics for Splenic Abscess

Drugs for Splenic Abscess (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meropenem Approved, Investigational Not Applicable 119478-56-7 64778 441130
2
Ceftazidime Approved Not Applicable 78439-06-2, 72558-82-8 5481173
3 Anti-Infective Agents Not Applicable
4 Anti-Bacterial Agents Not Applicable
5 Pharmaceutical Solutions Not Applicable
6 Thienamycins Not Applicable
7 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis Unknown status NCT00579956 Not Applicable Meropenem;Ceftazidime
2 Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584 Not Applicable
3 Yttrium-90 Radioembolization for Cirrhosis-Associated Thrombocytopenia Recruiting NCT03059030 Not Applicable

Search NIH Clinical Center for Splenic Abscess

Genetic Tests for Splenic Abscess

Anatomical Context for Splenic Abscess

MalaCards organs/tissues related to Splenic Abscess:

41
Spleen, Colon, Liver, B Cells, Myeloid, Pancreas, Neutrophil

Publications for Splenic Abscess

Articles related to Splenic Abscess:

(show top 50) (show all 453)
# Title Authors Year
1
A case report: Splenic abscess caused by Burkholderia pseudomallei. ( 29952975 )
2018
2
Clostridium Cadaveris Splenic Abscess in an Adolescent. ( 29611311 )
2018
3
Splenic abscess complicating endoscopic retrograde cholangiopancreatography. ( 29904296 )
2018
4
Pancreatic adenosquamous carcinoma masquerading as a locally invading splenic abscess. ( 29740918 )
2018
5
Massive splenic abscess secondary to haematogenous dissemination of Clostridium glycolium. ( 29753533 )
2018
6
Embolizing pulmonary aspergillosis, mycobacterial & aspergillous splenic abscess and cytomegalovirus co-infection following steroid induced immunosuppression: a case report. ( 30081818 )
2018
7
Successful Conservative Management of a Large Splenic Abscess Secondary to Infective Endocarditis. ( 30326233 )
2018
8
Delayed Intra Splenic Abscess: a Specific Complication Following Laparoscopic Sleeve Gastrectomy. ( 29248980 )
2018
9
Splenic Abscess: An Uncommon Entity with Potentially Life-Threatening Evolution. ( 29666665 )
2018
10
Fever of unknown origin due to primary tubercular splenic abscess in a low-income/middle-income country. ( 30150350 )
2018
11
Laparoscopic drainage of splenic abscess to avoid splenectomy. ( 30187605 )
2018
12
Rare case of Propionibacterium acnes-related splenic abscess. ( 30244225 )
2018
13
Splenic abscess following laparoscopic cholecystectomy: a case report of a rare disease and a review of its management. ( 30264011 )
2018
14
Splenic Abscess of an Unknown Etiology. ( 30266130 )
2018
15
From occult parodontopathy to splenic abscess leading to septic shock. ( 30524118 )
2018
16
Septicemic Melioidosis with Ruptured Splenic Abscess in a Patient with Thalassemia Intermedia. ( 28250624 )
2017
17
Case report of successful partial splenectomy for a splenic abscess in a paediatric patient. ( 28768231 )
2017
18
Salmonella Thompson splenic abscess in a healthy female. ( 28835413 )
2017
19
Systemic infection and splenic abscess. ( 28405071 )
2017
20
Isolated splenic abscess in brucellosis. ( 28473914 )
2017
21
Comparison of the Mortality in Emergency Department Sepsis Score, Modified Early Warning Score, Rapid Emergency Medicine Score and Rapid Acute Physiology Score for predicting the outcomes of adult splenic abscess patients in the emergency department. ( 29091954 )
2017
22
Infective endocarditis, embolic stroke and splenic abscess: a case report. ( 29423161 )
2017
23
Pylephlebitis with splenic abscess following transrectal prostate biopsy: rare complications of intra-abdominal infection. ( 28775833 )
2017
24
Gastric wall and splenic abscess in the background of an invasive salmonellosis caused by Salmonella enteritidis. ( 29150121 )
2017
25
Splenic Abscess Caused by Salmonella Typhi and Co-Infection with Leptospira. ( 29327530 )
2017
26
Splenic Abscess After Acute Pyelonephritis. ( 28215950 )
2017
27
Splenic abscess caused by Streptococcus anginosus following laparoscopic sleeve gastrectomy: a case report of a rare complication of bariatric surgery. ( 28458877 )
2017
28
Splenic Abscess: An Unusual Complication of Colon Cancer. ( 28912912 )
2017
29
Triad of infective endocarditis, splenic abscess, and septicemia caused by<i>Brucella melitensis</i>. ( 28966504 )
2017
30
Splenic Abscess in Immunocompetent Patients Managed Primarily without Splenectomy: A Series of 7 Cases. ( 28746018 )
2017
31
Splenic Abscess Requiring Early Splenectomy Following Angioembolization for Blunt Splenic Injury in an Immunocompromised Host: Implications for Management. ( 28206920 )
2016
32
Conservative management of splenic abscess septic emboli after tooth extractions. ( 26785862 )
2016
33
Splenic Abscess Requiring Early Splenectomy Following Angioembolization for Blunt Splenic Injury in an Immunocompromised Host: Implications for Management. ( 28877791 )
2016
34
Experience with Splenic Abscess from Southern India. ( 27891372 )
2016
35
Aseptic Splenic Abscess and Sweet Syndrome. ( 27111793 )
2016
36
Primary splenic abscess requiring splenectomy. ( 26991530 )
2016
37
Splenic abscess complicated by gastrosplenic fistula. ( 27306445 )
2016
38
Splenic abscess with portal venous gas caused by intrasplenic migration of an endoscopic double pigtail drain as a treatment of post-sleeve gastrectomy fistula. ( 26712579 )
2016
39
Splenic abscess due to fungal infection after kidney transplantation; a case report. ( 27689116 )
2016
40
Salmonella typhi Splenic Abscess Following Blunt Abdominal Injury: A Case Report. ( 27630844 )
2016
41
Colosplenic fistula as a complication of splenic abscess. ( 27459080 )
2016
42
Splenic Abscess with Bleeding in a Female Patient Following Coronary Artery Bypass Grafting and Cholecystectomy - A Case Report and Literature Review. ( 28141548 )
2016
43
Splenic abscess owing to cancer at the splenic flexure: A case report and comprehensive review. ( 27661050 )
2016
44
Pulmonary consolidation versus splenic abscess due to Salmonella enterica. ( 25443589 )
2016
45
Splenic Abscess Requiring Early Splenectomy Following Angioembolization for Blunt Splenic Injury in an Immunocompromised Host: Implications for Management. ( 30454215 )
2016
46
Splenic abscess in ulcerative colitis under anti tumor necrosis factor treatment. ( 26151700 )
2015
47
Sclerosing angiomatoid nodular transformation of spleen masquerading as a splenic abscess. ( 26275265 )
2015
48
Chronic Splenic Abscess as the First Manifestation of Pancreatic Tail Tumor. ( 27011620 )
2015
49
Splenic abscess in cancer chemotherapy. ( 26559779 )
2015
50
Cat-scratch disease presenting as a solitary splenic abscess in an elderly man. ( 25804947 )
2015

Variations for Splenic Abscess

Expression for Splenic Abscess

Search GEO for disease gene expression data for Splenic Abscess.

Pathways for Splenic Abscess

GO Terms for Splenic Abscess

Biological processes related to Splenic Abscess according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 8.8 CRP EPHX2 LIPA

Sources for Splenic Abscess

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....