MCID: SPL005
MIFTS: 34

Splenic Artery Aneurysm

Categories: Cardiovascular diseases

Aliases & Classifications for Splenic Artery Aneurysm

MalaCards integrated aliases for Splenic Artery Aneurysm:

Name: Splenic Artery Aneurysm 12 15
Aneurysm of Splenic Artery 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14006
ICD9CM 35 442.83
SNOMED-CT 68 70405009
UMLS 73 C0155747

Summaries for Splenic Artery Aneurysm

MalaCards based summary : Splenic Artery Aneurysm, also known as aneurysm of splenic artery, is related to portal hypertension and pancreatitis. An important gene associated with Splenic Artery Aneurysm is SAA1 (Serum Amyloid A1), and among its related pathways/superpathways are Pertussis and Lung fibrosis. Affiliated tissues include liver, spleen and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Splenic Artery Aneurysm

Graphical network of the top 20 diseases related to Splenic Artery Aneurysm:



Diseases related to Splenic Artery Aneurysm

Symptoms & Phenotypes for Splenic Artery Aneurysm

GenomeRNAi Phenotypes related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.6 ATP8B1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.6 CD163
3 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.6 ATP8B1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.6 CD163 UBC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.6 CD163
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.6 ATP8B1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.6 CD163
8 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.6 UBC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 UBC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.6 CD163
11 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.6 UBC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.6 CD163
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.6 ATP8B1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.6 ATP8B1 CD163 UBC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.6 CD163
16 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.6 CD163

Drugs & Therapeutics for Splenic Artery Aneurysm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison Between Open and Laparoscopic Splenic Aneurysms Repair Completed NCT01387828 Phase 3

Search NIH Clinical Center for Splenic Artery Aneurysm

Genetic Tests for Splenic Artery Aneurysm

Anatomical Context for Splenic Artery Aneurysm

MalaCards organs/tissues related to Splenic Artery Aneurysm:

41
Liver, Spleen, Kidney, Pancreas, Colon, Lung, Thymus

Publications for Splenic Artery Aneurysm

Articles related to Splenic Artery Aneurysm:

(show top 50) (show all 381)
# Title Authors Year
1
Laparoscopic endoscopic combined surgery for removal of migrated coil after embolization of ruptured splenic artery aneurysm. ( 29479413 )
2018
2
Splenic Artery Aneurysm Treated With Endovascular Stent Grafting: A Case Report and Review of Literature. ( 29940816 )
2018
3
Mass Image in Stomach: A Case of Splenic Artery Aneurysm. ( 29941720 )
2018
4
Acute fissuration of a giant splenic artery aneurysm detected by point-of-care ultrasound: case report. ( 29392549 )
2018
5
Syncope in a middle aged female: Splenic artery aneurysm revisited. ( 29494993 )
2018
6
A rare case of massive lower gastrointestinal bleeding from a ruptured splenic artery aneurysm. ( 29423167 )
2018
7
Spontaneous non-traumatic splenic artery aneurysm rupture: a case report and review of the literature. ( 29863260 )
2018
8
Endovascular Repair of Anomalous Splenic Artery Aneurysm with Systemic Lupus Erythematosus. ( 30217713 )
2018
9
Emergent embolization of a ruptured splenic artery aneurysm complicating Menkes disease. ( 30275920 )
2018
10
Spleno-pancreatectomy En Bloc with Parcelar Gastrectomy for Splenic Artery Aneurysm - A Case Report and Literature Review. ( 29936480 )
2018
11
Splenic Artery Aneurysm Causing Gastric Extraluminal Compression With a Positive Pillow Sign. ( 30086271 )
2018
12
Internal Coil Packing of an Amplatzer Vascular Plug after Incomplete Occlusion of the Afferent Vessel of a Splenic Artery Aneurysm. ( 30146209 )
2018
13
Endovascular and surgical management in intact splenic artery aneurysm. ( 30496903 )
2018
14
Successful use of resuscitative endovascular balloon occlusion of the aorta in the treatment of ruptured 8.5-cm splenic artery aneurysm. ( 28958475 )
2017
15
A Rare Clinical Case: Giant Splenic Artery Aneurysm and Its Successful Endovascular Treatment. ( 28785505 )
2017
16
Spontaneous splenic artery aneurysm rupture in a 38-year old female: a case report. ( 29182904 )
2017
17
Treatment of distal splenic artery aneurysm by laparoscopic aneurysmectomy with end-to-end anastomosis: A case report. ( 28489734 )
2017
18
Answer to Photo Quiz: Spontaneous rupture of a splenic artery aneurysm in a male patient. ( 29219833 )
2017
19
Splenic artery aneurysm with the double-rupture phenomenon. ( 28717782 )
2017
20
Giant splenic artery aneurysm in a pregnant patient: a case report and literature review. ( 28680611 )
2017
21
Surgical Treatment of Splenic Artery Aneurysm. ( 28318996 )
2017
22
The therapeutic challenge of giant splenic artery aneurysm: a case repport. ( 28746591 )
2017
23
Endovascular Repair of a Splenic Artery Aneurysm With Anomalous Origin From the Superior Mesenteric Artery. ( 28330438 )
2017
24
Emergency endovascular coiling of a ruptured giant splenic artery aneurysm. ( 29349435 )
2017
25
A splenic artery aneurysm presenting with multiple episodes of upper gastrointestinal bleeding: a case report. ( 28468689 )
2017
26
Spontaneous rupture of a splenic artery aneurysm in a male patient. ( 29219832 )
2017
27
3D Printing of Preoperative Simulation Models of a Splenic Artery Aneurysm: Precision and Accuracy. ( 28130050 )
2017
28
Spleen-Preserving Surgery in Splenic Artery Aneurysm. ( 29527384 )
2017
29
Successful resuscitation after splenic artery aneurysm rupture. ( 26957826 )
2016
30
Splenic artery aneurysm rupture in pregnancy. ( 28069418 )
2016
31
Splenic artery aneurysm presenting as a submucosal gastric lesion: A case report. ( 27499832 )
2016
32
Giant splenic artery aneurysm rupture. ( 27398212 )
2016
33
Surgical management of a splenic artery aneurysm. ( 27190621 )
2016
34
Computed Tomography Angiography in Diagnosis and Treatment of Splenic Artery Aneurysm. ( 26831243 )
2016
35
Rebleeding of a Splenic Artery Aneurysm after Coil Embolisation. ( 27872785 )
2016
36
Spontaneous rupture of the splenic artery aneurysm: a rare clinical presentation of acute abdomen. ( 27135088 )
2016
37
Splenic artery aneurysm. ( 27982336 )
2016
38
Genuine splenic artery aneurysm rupture treated by N-butyl cyanoacrylate and metallic coils under resuscitative endovascular balloon occlusion of the aorta. ( 29123801 )
2016
39
Intragastric Rupture of a Splenic Artery Aneurysm Associated with a Pancreatic Cancer. ( 30151446 )
2016
40
Giant splenic artery aneurysm. ( 25604380 )
2015
41
Splenic Artery Aneurysm Invaded by Desmoid-Type Fibromatosis. ( 26017693 )
2015
42
Hepatobiliary and Pancreatic: A splenic artery aneurysm presenting as a calcified pancreatic mass. ( 25776962 )
2015
43
Endovascular repair of a complex splenic artery aneurysm using a multilayer stent. ( 25918769 )
2015
44
Splenic artery aneurysm bleeding via the ampulla of Vater. ( 26397850 )
2015
45
Splenic Artery Aneurysm in Pregnancy. ( 26605452 )
2015
46
Rupture of splenic artery aneurysm in primipara five days after cesarean section: case report and review of the literature. ( 26373746 )
2015
47
Endovascular Treatment of Splenic Artery Aneurysm With a Stent-Graft: A Case Report. ( 26717355 )
2015
48
Ruptured splenic artery aneurysm detected by emergency ultrasound-a case report. ( 26069053 )
2015
49
Postmortem Computed Tomography Findings in Ruptured Splenic Artery Aneurysm: Value of the Clinical "Sentinel Clot" Sign in Identification of Bleeding Location. ( 26164764 )
2015
50
Uncommon cause of life-threatening retroperitoneal hemorrhage in a healthy young Hispanic patient: splenic artery aneurysm rupture. ( 26035985 )
2015

Variations for Splenic Artery Aneurysm

Expression for Splenic Artery Aneurysm

Search GEO for disease gene expression data for Splenic Artery Aneurysm.

Pathways for Splenic Artery Aneurysm

Pathways related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.25 SFTPA1 SFTPA2
2 11.12 SFTPA1 SFTPA2
3
Show member pathways
10.92 SFTPA1 SFTPA2
4
Show member pathways
10.79 SFTPA1 SFTPA2
5
Show member pathways
10.77 SFTPA1 SFTPA2 UBC
6
Show member pathways
10.35 SFTPA1 SFTPA2

GO Terms for Splenic Artery Aneurysm

Cellular components related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 APCS CD163 PCSK1N SAA1 SFTPA1 SFTPA2
2 extracellular space GO:0005615 9.43 APCS PCSK1N SAA1 SFTPA1 SFTPA2 UBC
3 endocytic vesicle membrane GO:0030666 9.4 CD163 UBC
4 rough endoplasmic reticulum GO:0005791 9.37 SFTPA1 SFTPA2
5 multivesicular body GO:0005771 9.26 SFTPA1 SFTPA2
6 clathrin-coated endocytic vesicle GO:0045334 9.16 SFTPA1 SFTPA2
7 lamellar body GO:0042599 8.62 SFTPA1 SFTPA2

Biological processes related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.58 HCK SAA1 UBC
2 positive regulation of phagocytosis GO:0050766 9.37 SFTPA1 SFTPA2
3 toll-like receptor signaling pathway GO:0002224 9.32 SFTPA1 SFTPA2
4 respiratory gaseous exchange GO:0007585 9.26 SFTPA1 SFTPA2
5 surfactant homeostasis GO:0043129 9.16 SFTPA1 SFTPA2
6 acute-phase response GO:0006953 9.13 APCS CD163 SAA1
7 cellular protein metabolic process GO:0044267 9.02 APCS SAA1 SFTPA1 SFTPA2 UBC

Molecular functions related to Splenic Artery Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 9.26 ATP8B1 SFTPA1
2 lipopolysaccharide binding GO:0001530 9.16 SFTPA1 SFTPA2
3 carbohydrate binding GO:0030246 9.13 APCS SFTPA1 SFTPA2
4 monosaccharide binding GO:0048029 8.62 SFTPA1 SFTPA2

Sources for Splenic Artery Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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