MCID: SPL060
MIFTS: 32

Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Categories: Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

MalaCards integrated aliases for Splenic Diffuse Red Pulp Small B-Cell Lymphoma:

Name: Splenic Diffuse Red Pulp Small B-Cell Lymphoma 59 73
Splenic Diffuse Red Pulp Lymphoma 59
Sdrpl 59

Classifications:



External Ids:

Orphanet 59 ORPHA300869
ICD10 via Orphanet 34 C83.0
UMLS 73 C2699508

Summaries for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

MalaCards based summary : Splenic Diffuse Red Pulp Small B-Cell Lymphoma, also known as splenic diffuse red pulp lymphoma, is related to b-cell lymphomas and lymphoma. An important gene associated with Splenic Diffuse Red Pulp Small B-Cell Lymphoma is CCNA2 (Cyclin A2), and among its related pathways/superpathways are GPCR Pathway and Influenza A. Affiliated tissues include b cells, t cells and spleen, and related phenotypes are cardiovascular system and embryo

Related Diseases for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Graphical network of the top 20 diseases related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma:



Diseases related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Symptoms & Phenotypes for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

MGI Mouse Phenotypes related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 BCOR CCND3 MAP2K1 NOTCH1 TP53
2 embryo MP:0005380 9.55 MAP2K1 NOTCH1 TP53 BCOR CCNA2
3 mortality/aging MP:0010768 9.43 BCOR CCNA2 CCND3 MAP2K1 NOTCH1 TP53
4 neoplasm MP:0002006 8.92 CCND3 MAP2K1 NOTCH1 TP53

Drugs & Therapeutics for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Search Clinical Trials , NIH Clinical Center for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Genetic Tests for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Anatomical Context for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

MalaCards organs/tissues related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma:

41
B Cells, T Cells, Spleen, Bone, Bone Marrow

Publications for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Articles related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma:

(show all 13)
# Title Authors Year
1
A rare case of splenic diffuse red pulp small B-cell lymphoma (SDRPL): a review of the literature on primary splenic lymphoma with hairy cells. ( 29662866 )
2018
2
Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations. ( 28069605 )
2017
3
Development of B-cell prolymphocytic leukemia in a patient with splenic diffuse red pulp small B-cell lymphoma. ( 29199492 )
2017
4
Cyclin A2 as a potential differential marker of splenic diffuse red pulp small B-cell lymphoma: a report of the first case. ( 27761608 )
2017
5
Exome sequencing identifies recurrent BCOR alterations and the absence of KLF2, TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma. ( 28751561 )
2017
6
Splenic diffuse red-pulp small B-cell lymphoma associated with hepatitis B virus: a report of two cases. ( 27581334 )
2016
7
NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease. ( 26426381 )
2016
8
Annexin A1 expression in a splenic diffuse red pulp small B-cell lymphoma: report of the first case. ( 23795986 )
2013
9
Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology? ( 23073320 )
2012
10
Concurrent splenic diffuse red pulp small B-cell lymphoma and benign clonal proliferation of T-cell large granular lymphocytes. ( 22385871 )
2012
11
Splenic diffuse red pulp small-B cell lymphoma: toward the emergence of a new lymphoma entity. ( 22541613 )
2012
12
Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL). ( 20677173 )
2011
13
Splenic diffuse red pulp small B-cell lymphoma: revision of a series of cases reveals characteristic clinico-pathological features. ( 20220064 )
2010

Variations for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Expression for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Search GEO for disease gene expression data for Splenic Diffuse Red Pulp Small B-Cell Lymphoma.

Pathways for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Pathways related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 CCNA2 CCND3 MAP2K1 NOTCH1 TP53
2
Show member pathways
12.52 CCND3 MAP2K1 TP53
3
Show member pathways
12.49 MAP2K1 NOTCH1 TP53
4
Show member pathways
12.48 MAP2K1 NOTCH1 TP53
5 12.48 CCND3 MAP2K1 NOTCH1 TP53
6
Show member pathways
12.38 CCNA2 CCND3 MAP2K1 NOTCH1 TP53
7
Show member pathways
12.28 CCNA2 MAP2K1 TP53
8
Show member pathways
12.27 CCNA2 CCND3 TP53
9
Show member pathways
12.23 CCNA2 MAP2K1 TP53
10 12.2 MAP2K1 NOTCH1 TP53
11 12.18 CCNA2 CCND3 TP53
12 12.05 CCNA2 CCND3 TP53
13
Show member pathways
12.02 CCNA2 CCND3 TP53
14 11.96 CCNA2 CCND3 TP53
15
Show member pathways
11.85 CCND3 MAP2K1
16
Show member pathways
11.71 CCND3 MAP2K1 TP53
17
Show member pathways
11.7 MAP2K1 TP53
18
Show member pathways
11.7 CCNA2 CCND3 TP53
19 11.64 MAP2K1 NOTCH1 TP53
20 11.52 MAP2K1 TP53
21 11.51 CCNA2 CCND3
22
Show member pathways
11.51 CCNA2 TP53
23 11.49 CCNA2 CCND3 TP53
24 11.47 CCND3 MAP2K1
25
Show member pathways
11.45 CCNA2 CCND3
26 11.44 MAP2K1 TP53
27 11.39 CCNA2 TP53
28 11.32 BCOR NOTCH1 TP53
29 11.31 CCNA2 TP53
30 11.3 CCND3 TP53
31 11.13 CCNA2 CCND3 MAP2K1 TP53
32 11.08 CCNA2 CCND3 TP53
33 11.07 MAP2K1 NOTCH1
34 10.64 CCNA2 CCND3 TP53

GO Terms for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Cellular components related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCNA2 CCND3

Biological processes related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.63 BCOR NOTCH1 TP53
2 negative regulation of cell proliferation GO:0008285 9.54 MAP2K1 NOTCH1 TP53
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.46 BCOR CCND3 NOTCH1 TP53
4 keratinocyte differentiation GO:0030216 9.43 MAP2K1 NOTCH1
5 heart development GO:0007507 9.43 BCOR MAP2K1 NOTCH1
6 Ras protein signal transduction GO:0007265 9.4 CCNA2 TP53
7 animal organ regeneration GO:0031100 9.32 CCNA2 NOTCH1
8 positive regulation of transcription, DNA-templated GO:0045893 9.26 CCNA2 MAP2K1 NOTCH1 TP53
9 cell cycle arrest GO:0007050 8.8 MAP2K1 NOTCH1 TP53

Molecular functions related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 8.8 CCNA2 CCND3 TP53

Sources for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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