MCID: SPL060
MIFTS: 34

Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

MalaCards integrated aliases for Splenic Diffuse Red Pulp Small B-Cell Lymphoma:

Name: Splenic Diffuse Red Pulp Small B-Cell Lymphoma 60 74
Splenic Diffuse Red Pulp Lymphoma 60
Sdrpl 60

Classifications:



External Ids:

ICD10 via Orphanet 35 C83.0
Orphanet 60 ORPHA300869
UMLS 74 C2699508

Summaries for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

MalaCards based summary : Splenic Diffuse Red Pulp Small B-Cell Lymphoma, also known as splenic diffuse red pulp lymphoma, is related to lymphoma and hepatitis. An important gene associated with Splenic Diffuse Red Pulp Small B-Cell Lymphoma is CCND3 (Cyclin D3), and among its related pathways/superpathways are GPCR Pathway and Gastric cancer. Affiliated tissues include b cells, bone and t cells, and related phenotypes are cardiovascular system and embryo

Related Diseases for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Graphical network of the top 20 diseases related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma:



Diseases related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Symptoms & Phenotypes for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

MGI Mouse Phenotypes related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.72 BCOR CCND3 MAP2K1 NOTCH1 TP53
2 embryo MP:0005380 9.65 BCOR CCNA2 MAP2K1 NOTCH1 TP53
3 hematopoietic system MP:0005397 9.55 BCOR CCNA2 CCND3 NOTCH1 TP53
4 mortality/aging MP:0010768 9.43 BCOR CCNA2 CCND3 MAP2K1 NOTCH1 TP53
5 neoplasm MP:0002006 8.92 CCND3 MAP2K1 NOTCH1 TP53

Drugs & Therapeutics for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Search Clinical Trials , NIH Clinical Center for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Genetic Tests for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Anatomical Context for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

MalaCards organs/tissues related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma:

42
B Cells, Bone, T Cells, Tongue, Spleen, Bone Marrow, Spinal Cord

Publications for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Articles related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma:

(show all 15)
# Title Authors Year
1
Development of B-cell prolymphocytic leukemia in a patient with splenic diffuse red pulp small B-cell lymphoma. ( 29199492 )
2018
2
A rare case of splenic diffuse red pulp small B-cell lymphoma (SDRPL): a review of the literature on primary splenic lymphoma with hairy cells. ( 29662866 )
2018
3
Cyclin A2 as a potential differential marker of splenic diffuse red pulp small B-cell lymphoma: a report of the first case. ( 27761608 )
2017
4
Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations. ( 28069605 )
2017
5
Exome sequencing identifies recurrent BCOR alterations and the absence of KLF2, TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma. ( 28751561 )
2017
6
Splenic diffuse red pulp lymphoma has a distinct pattern of somatic mutations amongst B-cell malignancies. ( 27347751 )
2017
7
NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease. ( 26426381 )
2016
8
Splenic diffuse red-pulp small B-cell lymphoma associated with hepatitis B virus: a report of two cases. ( 27581334 )
2016
9
A Single-center Experience in Splenic Diffuse Red Pulp Lymphoma Diagnosis. ( 27131623 )
2016
10
Annexin A1 expression in a splenic diffuse red pulp small B-cell lymphoma: report of the first case. ( 23795986 )
2013
11
Concurrent splenic diffuse red pulp small B-cell lymphoma and benign clonal proliferation of T-cell large granular lymphocytes. ( 22385871 )
2012
12
Splenic diffuse red pulp small-B cell lymphoma: toward the emergence of a new lymphoma entity. ( 22541613 )
2012
13
Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology? ( 23073320 )
2012
14
Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL). ( 20677173 )
2011
15
Splenic diffuse red pulp small B-cell lymphoma: revision of a series of cases reveals characteristic clinico-pathological features. ( 20220064 )
2010

Variations for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Expression for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Search GEO for disease gene expression data for Splenic Diffuse Red Pulp Small B-Cell Lymphoma.

Pathways for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Pathways related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 CCNA2 CCND3 MAP2K1 NOTCH1 TP53
2
Show member pathways
12.48 MAP2K1 NOTCH1 TP53
3 12.46 CCND3 MAP2K1 NOTCH1 TP53
4
Show member pathways
12.41 MAP2K1 NOTCH1 TP53
5
Show member pathways
12.39 CCNA2 CCND3 MAP2K1 NOTCH1 TP53
6
Show member pathways
12.29 CCNA2 CCND3 TP53
7
Show member pathways
12.25 CCNA2 MAP2K1 TP53
8 12.22 MAP2K1 NOTCH1 TP53
9 12.21 CCNA2 CCND3 TP53
10 12.11 CCNA2 CCND3 TP53
11
Show member pathways
12.07 CCND3 MAP2K1 TP53
12 12.03 CCNA2 CCND3 TP53
13
Show member pathways
12 CCNA2 CCND3 TP53
14 11.94 CCNA2 CCND3 TP53
15
Show member pathways
11.88 CCND3 MAP2K1 TP53
16
Show member pathways
11.7 CCNA2 CCND3 TP53
17 11.64 MAP2K1 NOTCH1 TP53
18 11.52 MAP2K1 TP53
19 11.51 CCNA2 CCND3
20
Show member pathways
11.51 CCNA2 TP53
21 11.49 CCNA2 CCND3 TP53
22 11.47 CCND3 MAP2K1
23
Show member pathways
11.45 CCNA2 CCND3
24 11.44 MAP2K1 TP53
25 11.39 CCNA2 TP53
26 11.32 CCNA2 TP53
27 11.32 BCOR NOTCH1 TP53
28 11.3 CCND3 TP53
29 11.13 CCNA2 CCND3 MAP2K1 TP53
30 11.09 MAP2K1 NOTCH1
31 11.08 CCNA2 CCND3 TP53
32 10.64 CCNA2 CCND3 TP53

GO Terms for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Cellular components related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCNA2 CCND3

Biological processes related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 CCNA2 CCND3 NOTCH1
2 negative regulation of cell proliferation GO:0008285 9.67 MAP2K1 NOTCH1 TP53
3 positive regulation of gene expression GO:0010628 9.65 MAP2K1 NOTCH1 TP53
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.56 BCOR CCND3 NOTCH1 TP53
5 keratinocyte differentiation GO:0030216 9.52 MAP2K1 NOTCH1
6 Ras protein signal transduction GO:0007265 9.51 CCNA2 TP53
7 heart development GO:0007507 9.5 BCOR MAP2K1 NOTCH1
8 positive regulation of cell cycle GO:0045787 9.46 CCNA2 CCND3
9 positive regulation of transcription, DNA-templated GO:0045893 9.46 CCNA2 MAP2K1 NOTCH1 TP53
10 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.43 CCNA2 CCND3
11 animal organ regeneration GO:0031100 9.4 CCNA2 NOTCH1
12 regulation of mitotic nuclear division GO:0007088 9.37 CCNA2 CCND3
13 cell cycle arrest GO:0007050 9.13 MAP2K1 NOTCH1 TP53
14 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.62 MAP2K1 TP53

Molecular functions related to Splenic Diffuse Red Pulp Small B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.33 CCNA2 CCND3 MAP2K1
2 protein kinase binding GO:0019901 9.13 CCNA2 CCND3 TP53
3 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 8.62 CCNA2 CCND3

Sources for Splenic Diffuse Red Pulp Small B-Cell Lymphoma

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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
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31 HGMD
32 HMDB
33 HPO
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35 ICD10 via Orphanet
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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55 NINDS
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58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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