MCID: SPL012
MIFTS: 42

Splenic Disease

Categories: Immune diseases, Blood diseases

Aliases & Classifications for Splenic Disease

MalaCards integrated aliases for Splenic Disease:

Name: Splenic Disease 12 15
Splenic Diseases 44 73
Abnormality of the Spleen 29
Spleen Diseases 43
Spleen Disease 12
Dyssplenism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2529
ICD10 33 D73 D73.9
ICD9CM 35 289.50
MeSH 44 D013158
NCIt 50 C35823
UMLS 73 C0037997

Summaries for Splenic Disease

MedlinePlus : 43 Your spleen is an organ above your stomach and under your ribs on your left side. It is about as big as your fist. The spleen is part of your lymphatic system, which fights infection and keeps your body fluids in balance. It contains white blood cells that fight germs. Your spleen also helps control the amount of blood in your body, and destroys old and damaged cells. Certain diseases might cause your spleen to swell. You can also damage or rupture your spleen in an injury, especially if it is already swollen. If your spleen is too damaged, you might need surgery to remove it. You can live without a spleen. Other organs, such as your liver, will take over some of the spleen's work. Without a spleen, however, your body will lose some of its ability to fight infections.

MalaCards based summary : Splenic Disease, also known as splenic diseases, is related to nodal marginal zone lymphoma and spleen cancer, and has symptoms including hepatosplenomegaly An important gene associated with Splenic Disease is IER3IP1 (Immediate Early Response 3 Interacting Protein 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Aspirin and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and heart.

Wikipedia : 76 Splenic diseases include splenomegaly, where the spleen is enlarged for various reasons. On the other... more...

Related Diseases for Splenic Disease

Diseases related to Splenic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 nodal marginal zone lymphoma 10.9
2 spleen cancer 10.9
3 splenic sequestration 10.8 HBB THPO
4 splenic infarction 10.7 F2 HBB
5 hemoglobin e disease 10.7 F2 HBB
6 thrombocytopenia due to platelet alloimmunization 10.7 CD40LG THPO
7 livedoid vasculopathy 10.7 CD40LG F2
8 antipyrine metabolism 10.7 ALB F2
9 non-a-e hepatitis 10.7 ALB F2
10 buruli ulcer 10.6 CD40LG HBB
11 abdominal tuberculosis 10.6 ALB F2
12 colorado tick fever 10.6 ALB CD40LG
13 primary thrombocytopenia 10.6 CD40LG THPO
14 cork-handlers' disease 10.6 ALB CD40LG
15 acute chest syndrome 10.6 CD40LG HBB
16 kwashiorkor 10.6 ALB F2
17 hepatitis d 10.6 CD40LG F2
18 plasmodium malariae malaria 10.6 ALB CD40LG
19 hepatic tuberculosis 10.6 ALB F2
20 autoimmune disease of blood 10.6 CD40LG THPO
21 hepatic coma 10.6 ALB F2
22 yellow nail syndrome 10.6 ALB CD40LG
23 exanthema subitum 10.6 CD40LG THPO
24 esophageal varix 10.6 ALB F2
25 ascending cholangitis 10.6 ALB F2
26 diffuse glomerulonephritis 10.6 ALB CD40LG
27 aleutian mink disease 10.6 ALB CD40LG
28 non-secretory myeloma 10.5 ALB CD40LG
29 transient arthritis 10.5 ALB CD40LG
30 folic acid deficiency anemia 10.5 EPO THPO
31 hypersensitivity reaction type iii disease 10.5 ALB CD40LG
32 cerebral falx meningioma 10.5 F2 F3
33 intestinal impaction 10.5 F2 F3
34 compartment syndrome 10.5 ALB F2
35 cerebral sinovenous thrombosis 10.5 F2 F3
36 leech infestation 10.5 F2 F3
37 acute cystitis 10.5 ALB IER3IP1
38 qualitative platelet defect 10.5 F2 F3
39 giant hemangioma 10.5 F2 F3
40 sagittal sinus thrombosis 10.5 F2 F3
41 von willebrand disease, type 1 10.5 F2 F3
42 blue toe syndrome 10.5 F2 F3
43 intracranial embolism 10.5 F2 F3
44 pleuropneumonia 10.5 CD40LG HBB
45 heparin-induced thrombocytopenia 10.5 CD40LG F3
46 femoral neuropathy 10.5 F2 F3
47 choledocholithiasis 10.5 ALB F2
48 alcohol-related birth defect 10.5 F2 F3
49 legionnaires' disease 10.5 ALB CD40LG
50 anterior cranial fossa meningioma 10.5 F2 F3

Graphical network of the top 20 diseases related to Splenic Disease:



Diseases related to Splenic Disease

Symptoms & Phenotypes for Splenic Disease

UMLS symptoms related to Splenic Disease:


hepatosplenomegaly

Drugs & Therapeutics for Splenic Disease

Drugs for Splenic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
3
Dalteparin Approved Phase 4 9005-49-6
4
Dipyridamole Approved Phase 4 58-32-2 3108
5
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
6 Nadroparin Approved, Investigational Phase 4 9041-08-1
7
Warfarin Approved Phase 4 81-81-2 6691 54678486
8 tannic acid Approved, Nutraceutical Phase 4
9 Liver Extracts Phase 4,Not Applicable
10 Analgesics Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Anticoagulants Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4
15 Antipyretics Phase 4
16 Antirheumatic Agents Phase 4
17 calcium heparin Phase 4
18 Calcium, Dietary Phase 4
19 Cyclooxygenase Inhibitors Phase 4
20 Fibrinolytic Agents Phase 4
21 Heparin, Low-Molecular-Weight Phase 4
22 Peripheral Nervous System Agents Phase 4
23 Phosphodiesterase Inhibitors Phase 4
24 Platelet Aggregation Inhibitors Phase 4
25 Vasodilator Agents Phase 4
26
Valproic Acid Approved, Investigational Phase 1, Phase 2 99-66-1 3121
27 Anticonvulsants Phase 1, Phase 2
28 Antimanic Agents Phase 1, Phase 2
29 Central Nervous System Depressants Phase 1, Phase 2
30 GABA Agents Phase 1, Phase 2
31 Neurotransmitter Agents Phase 1, Phase 2
32 Psychotropic Drugs Phase 1, Phase 2
33 Tranquilizing Agents Phase 1, Phase 2
34 Kava Approved, Investigational, Nutraceutical 9000-38-8
35
Imidacloprid Vet_approved 105827-78-9 86418

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy Recruiting NCT02238444 Phase 4 Warfarin;Dipyridamole;Aspirin;Low Molecular Weight Heparin
2 Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS) Completed NCT00605657 Phase 1, Phase 2 Valproic Acid
3 Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584 Not Applicable
4 Non-traumatic Rupture of the Spleen. Can Splenectomy be Applied Selectively? Unknown status NCT01845662
5 Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis Unknown status NCT01201655
6 Prospective Randomized Comparison of Clinical Results of Hand Assisted Laparoscopic Splenectomies and Open Splenectomies Completed NCT00754806
7 Outcome After Conservative and Surgical Treatment of Splenic Injuries After Blunt Abdominal Trauma. Completed NCT00910182
8 Defining Immunodeficiency in Heterotaxy Syndrome: Pilot Study Data Completed NCT01929967
9 Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study Completed NCT01591928
10 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
11 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
12 Ultrasound Emergency Diagnosis of Small Bowel Obstruction Not yet recruiting NCT03226665
13 Hypersplenism in Patients With Liver Cirrhosis and Portal Hypertension Not yet recruiting NCT03269877
14 Racial Distribution of Heterotaxy Syndrome Terminated NCT00485654

Search NIH Clinical Center for Splenic Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: splenic diseases

Genetic Tests for Splenic Disease

Genetic tests related to Splenic Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Spleen 29

Anatomical Context for Splenic Disease

MalaCards organs/tissues related to Splenic Disease:

41
Spleen, Liver, Heart

Publications for Splenic Disease

Articles related to Splenic Disease:

(show all 23)
# Title Authors Year
1
Molecular detection of vector-borne pathogens in blood and splenic samples from dogs with splenic disease. ( 28285583 )
2017
2
No evidence of splenic disease in patients with splenic marginal zone lymphoma undergoing splenectomy for autoimmune hemolytic anemia after monotherapy with rituximab. ( 27082039 )
2016
3
Histopathological correlation of splenic disease with radiological and surgical findings: should we incorporate splenectomy into standard procedures for disseminated Millerian adenocarcinoma? ( 29787010 )
2016
4
Correction: In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosmiasis. ( 26474175 )
2015
5
In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosmiasis. ( 26394390 )
2015
6
Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma sp. in dogs with splenic disease. ( 22092618 )
2011
7
Use of an ultrasonically activated scalpel for splenectomy in 10 dogs with naturally occurring splenic disease. ( 15860110 )
2005
8
Experience with benign splenic disease. ( 15571023 )
2004
9
Ultrasonographic appearance of splenic disease in 101 cats. ( 11678567 )
2001
10
Surgical management of splenic disease. ( 11226539 )
2001
11
Community-acquired Staphylococcus epidermidis endocarditis complicated by splenic disease 9 years after aortic valve replacement. ( 10680992 )
1999
12
Surgical aspects of splenic disease and lymphoma. ( 9663186 )
1998
13
Contrast-enhanced MR imaging of diffuse and focal splenic disease with use of magnetic starch microspheres. ( 8061436 )
1994
14
Focal splenic disease demonstrated by ultrasound and computed tomography. ( 3884617 )
1985
15
Rectus sheath hematoma mimicking acute splenic disease. ( 6225332 )
1983
16
Splenic disease. ( 625270 )
1978
17
Hepato splenic disease caused by Bilharzia haematobium in Upper Egypt. ( 4817356 )
1974
18
Elective splenectomy for primary hematologic and splenic disease. ( 5270604 )
1970
19
Splenic disease diagnosis by radioisotope scanning. ( 14004363 )
1962
20
Surgical aspects of splenic disease. ( 14387371 )
1955
21
Surgical aspects of splenic disease. ( 14387366 )
1955
22
Effect of splenic function and splenic disease on female physiology, with a brief analysis of 182 gestations after splenectomy. ( 15436199 )
1950
23
Surgical aspects of splenic disease. ( 18141301 )
1949

Variations for Splenic Disease

Expression for Splenic Disease

Search GEO for disease gene expression data for Splenic Disease.

Pathways for Splenic Disease

Pathways related to Splenic Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.1 ALB F2 F3 HBB THPO
2
Show member pathways
11.46 ALB F2 HBB
3 10.72 CD40LG RFXANK

GO Terms for Splenic Disease

Cellular components related to Splenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 ADAM17 CD40LG EPO F3
2 extracellular region GO:0005576 9.5 ALB CD40LG EPO F2 F3 HBB
3 blood microparticle GO:0072562 9.33 ALB F2 HBB
4 extracellular space GO:0005615 9.17 ALB CD40LG EPO F2 F3 HBB

Biological processes related to Splenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.33 F2 F3 HBB
2 acute-phase response GO:0006953 9.26 EPO F2
3 positive regulation of protein phosphorylation GO:0001934 9.13 ADAM17 F2 THPO
4 regulation of signaling receptor activity GO:0010469 8.92 CD40LG EPO F2 THPO

Molecular functions related to Splenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CD40LG EPO THPO

Sources for Splenic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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