MCID: SPL012
MIFTS: 39

Splenic Disease

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Splenic Disease

MalaCards integrated aliases for Splenic Disease:

Name: Splenic Disease 12 15
Splenic Diseases 44 73
Abnormality of the Spleen 29
Spleen Diseases 43
Spleen Disease 12
Dyssplenism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2529
ICD10 33 D73 D73.9
ICD9CM 35 289.50
MeSH 44 D013158
NCIt 50 C35823
SNOMED-CT 68 51244008 58381000
UMLS 73 C0037997

Summaries for Splenic Disease

MedlinePlus : 43 Your spleen is an organ above your stomach and under your ribs on your left side. It is about as big as your fist. The spleen is part of your lymphatic system, which fights infection and keeps your body fluids in balance. It contains white blood cells that fight germs. Your spleen also helps control the amount of blood in your body, and destroys old and damaged cells. Certain diseases might cause your spleen to swell. You can also damage or rupture your spleen in an injury, especially if it is already swollen. If your spleen is too damaged, you might need surgery to remove it. You can live without a spleen. Other organs, such as your liver, will take over some of the spleen's work. Without a spleen, however, your body will lose some of its ability to fight infections.

MalaCards based summary : Splenic Disease, also known as splenic diseases, is related to nodal marginal zone lymphoma and spleen cancer, and has symptoms including hepatosplenomegaly An important gene associated with Splenic Disease is THPO (Thrombopoietin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Warfarin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and heart, and related phenotype is normal.

Wikipedia : 76 Splenic diseases include splenomegaly, where the spleen is enlarged for various reasons. On the other... more...

Related Diseases for Splenic Disease

Diseases related to Splenic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 nodal marginal zone lymphoma 11.0
2 spleen cancer 11.0
3 splenic sequestration 10.3 HBB THPO
4 hemoglobin e disease 10.2 F2 HBB
5 antipyrine metabolism 10.2 ALB F2
6 non-a-e hepatitis 10.2 ALB F2
7 epstein-barr virus hepatitis 10.2 ALB F2
8 abdominal tuberculosis 10.2 ALB F2
9 cerebral falx meningioma 10.2 F2 F3
10 hepatic tuberculosis 10.2 ALB F2
11 leech infestation 10.2 F2 F3
12 prothrombin deficiency 10.2 F2 F3
13 kwashiorkor 10.2 ALB F2
14 intestinal impaction 10.2 F2 F3
15 cerebral sinovenous thrombosis 10.2 F2 F3
16 hepatic coma 10.2 ALB F2
17 qualitative platelet defect 10.2 F2 F3
18 giant hemangioma 10.2 F2 F3
19 infantile liver failure syndrome 1 10.2 ALB F2
20 sagittal sinus thrombosis 10.2 F2 F3
21 blue toe syndrome 10.2 F2 F3
22 blind loop syndrome 10.2 ALB HBB
23 femoral neuropathy 10.2 F2 F3
24 alcohol-related birth defect 10.2 F2 F3
25 esophageal varix 10.2 ALB F2
26 hantavirus pulmonary syndrome 10.2 F2 F3
27 ascending cholangitis 10.2 ALB F2
28 von willebrand disease, type 1 10.2 F2 F3
29 anterior cranial fossa meningioma 10.2 F2 F3
30 korean hemorrhagic fever 10.2 F2 F3
31 marantic endocarditis 10.2 F2 F3
32 vascular hemostatic disease 10.2 F2 F3
33 purpura fulminans 10.2 F2 F3
34 compartment syndrome 10.2 ALB F2
35 hepatorenal syndrome 10.2 ALB F2
36 peripheral vertigo 10.2 F2 F3
37 inherited blood coagulation disease 10.2 F2 F3
38 choledocholithiasis 10.2 ALB F2
39 coenurosis 10.2 F2 MT-CO1
40 acute cystitis 10.2 ALB IER3IP1
41 hemophilia 10.2 F2 F3
42 endocardium disease 10.2 F2 F3
43 transient arthritis 10.2 ALB F3
44 branch retinal artery occlusion 10.2 F2 F3
45 autoimmune disease of urogenital tract 10.2 ALB F2
46 dysentery 10.2 ALB IER3IP1
47 dysfibrinogenemia 10.2 ALB F2
48 factor xi deficiency 10.1 F2 F3
49 squamous cell papilloma 10.1 F2 F3
50 portal hypertension 10.1 ALB F2 THPO

Graphical network of the top 20 diseases related to Splenic Disease:



Diseases related to Splenic Disease

Symptoms & Phenotypes for Splenic Disease

UMLS symptoms related to Splenic Disease:


hepatosplenomegaly

MGI Mouse Phenotypes related to Splenic Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 ADAM17 ALB EPO F2 F3 GBA

Drugs & Therapeutics for Splenic Disease

Drugs for Splenic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 4 81-81-2 6691 54678486
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
5
Dipyridamole Approved Phase 4 58-32-2 3108
6
Nadroparin Approved, Investigational Phase 4
7
Dalteparin Approved Phase 4 9005-49-6
8 tannic acid Approved Phase 4
9 Liver Extracts Phase 4,Not Applicable
10 Vasodilator Agents Phase 4
11 Antipyretics Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Analgesics Phase 4
14 Calcium, Dietary Phase 4
15 Fibrinolytic Agents Phase 4
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Analgesics, Non-Narcotic Phase 4
18 Anticoagulants Phase 4
19 Antirheumatic Agents Phase 4
20 Heparin, Low-Molecular-Weight Phase 4
21 calcium heparin Phase 4
22 Cyclooxygenase Inhibitors Phase 4
23 Platelet Aggregation Inhibitors Phase 4
24 Peripheral Nervous System Agents Phase 4
25 Phosphodiesterase Inhibitors Phase 4
26
Valproic Acid Approved, Investigational Phase 1, Phase 2 99-66-1 3121
27 Central Nervous System Depressants Phase 1, Phase 2
28 Antimanic Agents Phase 1, Phase 2
29 Neurotransmitter Agents Phase 1, Phase 2
30 Tranquilizing Agents Phase 1, Phase 2
31 GABA Agents Phase 1, Phase 2
32 Psychotropic Drugs Phase 1, Phase 2
33 Anticonvulsants Phase 1, Phase 2
34 Kava Approved, Investigational, Nutraceutical 9000-38-8
35
Imidacloprid Vet_approved 105827-78-9 86418

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Warfarin Prevents Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy Recruiting NCT02238444 Phase 4 Warfarin;Dipyridamole;Aspirin;Low Molecular Weight Heparin
2 Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS) Completed NCT00605657 Phase 1, Phase 2 Valproic Acid
3 Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584 Not Applicable
4 Non-traumatic Rupture of the Spleen. Can Splenectomy be Applied Selectively? Unknown status NCT01845662
5 Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis Unknown status NCT01201655
6 Prospective Randomized Comparison of Clinical Results of Hand Assisted Laparoscopic Splenectomies and Open Splenectomies Completed NCT00754806
7 Outcome After Conservative and Surgical Treatment of Splenic Injuries After Blunt Abdominal Trauma. Completed NCT00910182
8 Defining Immunodeficiency in Heterotaxy Syndrome: Pilot Study Data Completed NCT01929967
9 Heterotaxy Syndrome and Intestinal Rotation Abnormalities - A Prospective Study Completed NCT01591928
10 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
11 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
12 Ultrasound Emergency Diagnosis of Small Bowel Obstruction Not yet recruiting NCT03226665
13 Hypersplenism in Patients With Liver Cirrhosis and Portal Hypertension Not yet recruiting NCT03269877
14 Racial Distribution of Heterotaxy Syndrome Terminated NCT00485654

Search NIH Clinical Center for Splenic Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: splenic diseases

Genetic Tests for Splenic Disease

Genetic tests related to Splenic Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Spleen 29

Anatomical Context for Splenic Disease

MalaCards organs/tissues related to Splenic Disease:

41
Spleen, Liver, Heart

Publications for Splenic Disease

Articles related to Splenic Disease:

(show all 31)
# Title Authors Year
1
Molecular detection of vector-borne pathogens in blood and splenic samples from dogs with splenic disease. ( 28285583 )
2017
2
No evidence of splenic disease in patients with splenic marginal zone lymphoma undergoing splenectomy for autoimmune hemolytic anemia after monotherapy with rituximab. ( 27082039 )
2016
3
Histopathological correlation of splenic disease with radiological and surgical findings: should we incorporate splenectomy into standard procedures for disseminated Millerian adenocarcinoma? ( 29787010 )
2016
4
Correction: In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosmiasis. ( 26474175 )
2015
5
In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosmiasis. ( 26394390 )
2015
6
Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities. ( 25055265 )
2014
7
Primary versus secondary splenic pedicle dissection in laparoscopic splenectomy for splenic diseases. ( 23206537 )
2013
8
Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma sp. in dogs with splenic disease. ( 22092618 )
2011
9
Single incision approach for splenic diseases: a preliminary report on a series of 8 cases. ( 20177924 )
2010
10
Use of an ultrasonically activated scalpel for splenectomy in 10 dogs with naturally occurring splenic disease. ( 15860110 )
2005
11
Experience with benign splenic disease. ( 15571023 )
2004
12
Emergency laparoscopic splenectomy for "wandering" (pelvic) spleen: case report and review of the literature on laparoscopic approach to splenic diseases. ( 12045854 )
2002
13
Ultrasonographic appearance of splenic disease in 101 cats. ( 11678567 )
2001
14
Surgical management of splenic disease. ( 11226539 )
2001
15
Community-acquired Staphylococcus epidermidis endocarditis complicated by splenic disease 9 years after aortic valve replacement. ( 10680992 )
1999
16
Surgical aspects of splenic disease and lymphoma. ( 9663186 )
1998
17
Contrast-enhanced MR imaging of diffuse and focal splenic disease with use of magnetic starch microspheres. ( 8061436 )
1994
18
Ultrasound or CT in splenic diseases? ( 7946685 )
1994
19
Prevalence and type of splenic diseases in cats: 455 cases (1985-1991). ( 1399784 )
1992
20
Prevalence, type, and importance of splenic diseases in dogs: 1,480 cases (1985-1989). ( 1568933 )
1992
21
The spleen: diagnosis of splenic diseases using radiolabeled tracers. ( 2675910 )
1989
22
Focal splenic disease demonstrated by ultrasound and computed tomography. ( 3884617 )
1985
23
Rectus sheath hematoma mimicking acute splenic disease. ( 6225332 )
1983
24
Splenic disease. ( 625270 )
1978
25
Hepato splenic disease caused by Bilharzia haematobium in Upper Egypt. ( 4817356 )
1974
26
Elective splenectomy for primary hematologic and splenic disease. ( 5270604 )
1970
27
Splenic disease diagnosis by radioisotope scanning. ( 14004363 )
1962
28
Surgical aspects of splenic disease. ( 14387371 )
1955
29
Surgical aspects of splenic disease. ( 14387366 )
1955
30
Effect of splenic function and splenic disease on female physiology, with a brief analysis of 182 gestations after splenectomy. ( 15436199 )
1950
31
Surgical aspects of splenic disease. ( 18141301 )
1949

Variations for Splenic Disease

Expression for Splenic Disease

Search GEO for disease gene expression data for Splenic Disease.

Pathways for Splenic Disease

Pathways related to Splenic Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 ALB F2 F3 HBB THPO
2
Show member pathways
11.13 ALB F2 HBB

GO Terms for Splenic Disease

Cellular components related to Splenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ALB EPO F2 F3 GBA HBB
2 blood microparticle GO:0072562 9.13 ALB F2 HBB

Biological processes related to Splenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.62 ADAM17 EPO F2 THPO
2 blood coagulation GO:0007596 9.43 F2 F3 HBB
3 acute-phase response GO:0006953 9.4 EPO F2
4 response to testosterone GO:0033574 9.37 EPO GBA
5 positive regulation of protein phosphorylation GO:0001934 9.33 ADAM17 F2 THPO
6 response to electrical stimulus GO:0051602 8.96 EPO MT-CO1
7 response to dexamethasone GO:0071548 8.62 EPO GBA

Molecular functions related to Splenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 8.62 ALB HBB

Sources for Splenic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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