MCID: SPL012
MIFTS: 45

Splenic Disease

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Splenic Disease

MalaCards integrated aliases for Splenic Disease:

Name: Splenic Disease 12 15 17
Splenic Diseases 44 70
Abnormality of the Spleen 29
Spleen Diseases 42
Spleen Disease 12
Dyssplenism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2529
ICD9CM 34 289.50
MeSH 44 D013158
NCIt 50 C35823
SNOMED-CT 67 51244008
ICD10 32 D73 D73.9
UMLS 70 C0037997

Summaries for Splenic Disease

MedlinePlus : 42 Your spleen is an organ above your stomach and under your ribs on your left side. It is about as big as your fist. The spleen is part of your lymphatic system, which fights infection and keeps your body fluids in balance. It contains white blood cells that fight germs. Your spleen also helps control the amount of blood in your body, and destroys old and damaged cells. Certain diseases might cause your spleen to swell. You can also damage or rupture your spleen in an injury, especially if it is already swollen. If your spleen is too damaged, you might need surgery to remove it. You can live without a spleen. Other organs, such as your liver, will take over some of the spleen's work. Without a spleen, however, your body will lose some of its ability to fight infections.

MalaCards based summary : Splenic Disease, also known as splenic diseases, is related to splenic infarction and pulmonary edema, and has symptoms including hepatosplenomegaly An important gene associated with Splenic Disease is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. Affiliated tissues include spleen, lymph node and liver, and related phenotypes are immune system and hematopoietic system

Wikipedia : 73 The spleen is an organ found in all vertebrates. Similar in structure to a large lymph node, it acts... more...

Related Diseases for Splenic Disease

Diseases related to Splenic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 794)
# Related Disease Score Top Affiliating Genes
1 splenic infarction 30.4 GPT F2 ALB
2 pulmonary edema 30.2 TNF IL10 F2
3 mast cell neoplasm 30.2 U2AF1 IL2 H2AC18 CD8A
4 sleeping sickness 30.2 LMLN IL10 H2AC18
5 hepatitis e 30.1 TNF IFNG GPT F2 ALB
6 echinococcosis 30.1 TNF IL10 IFNG CD8A
7 histiocytosis 30.1 U2AF1 TNF IFNG CCR6
8 lymphangioma 30.0 IFNG H2AC18 CCR6
9 hypersplenism 30.0 THPO IL4 IFNG GPT F2 CD4
10 endocarditis 30.0 TNF IL10 IFNG F2 ALB
11 anemia, autoimmune hemolytic 29.9 IGHV4-38-2 CD8A CD5 CD4 CD19 CCR6
12 purpura 29.9 TNF THPO IL4 IL10 IFNG F2
13 portal hypertension 29.8 TNF THPO GPT F2 CD4 ALB
14 marginal zone b-cell lymphoma 29.8 U2AF1 SIGLEC5 IGHV4-38-2 CD5 CD19 CCR6
15 vascular disease 29.8 TNF IL2 IL10 IFNG F2 CD4
16 sarcoidosis 1 29.7 TNF SLC11A1 IL2 IFNG CD8A CD4
17 trypanosomiasis 29.7 TNF IL4 IL10 IFNG H2AC18 GPT
18 intestinal schistosomiasis 29.7 TNF SIGLEC5 IL4 IL2 IL10 CD8A
19 hemolytic anemia 29.7 TNF IL4 IL2 IL10 IFNG F2
20 schistosomiasis 29.6 TNF IL4 IL2 IL10 IFNG GPT
21 aplastic anemia 29.5 U2AF1 TNF THPO IL4 IL2 IL10
22 liver cirrhosis 29.4 TNF THPO IL2 IL10 IFNG GPT
23 deficiency anemia 29.1 U2AF1 TNF THPO SLC11A1 H2AC18 GPT
24 nodal marginal zone lymphoma 11.0
25 punctate inner choroidopathy 10.5 TNF IL10
26 elephantiasis 10.5 IL4 IL10 CD4
27 riedel's fibrosing thyroiditis 10.5 CD4 ALB
28 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.5 IL4 IL2
29 myelitis 10.5 TNF IL10 CCR6
30 non-a-e hepatitis 10.5 F2 ALB
31 early yaws 10.5 CD8A CD4
32 antipyrine metabolism 10.5 F2 ALB
33 tropical endomyocardial fibrosis 10.5 TNF IL4 IL10
34 endomyocardial fibrosis 10.5 TNF IL4 IL10
35 loiasis 10.5 IL4 IL10 CD4
36 subcutaneous mycosis 10.5 IL10 CD4 CCR6
37 oral hairy leukoplakia 10.5 IL10 CD8A CD4
38 ventilation pneumonitis 10.5 CD8A CD4
39 trichinosis 10.5 IL4 IL10 CD4
40 multifocal choroiditis 10.5 TNF IL10
41 timothy grass allergy 10.5 IL4 IL10 CD4
42 cork-handlers' disease 10.5 CD8A CD4 ALB
43 esophageal candidiasis 10.5 CD8A CD4 CCR6
44 scabies 10.5 IL10 CD4 CCR6
45 inflammatory bowel disease 18 10.5 IL4 IL10 CCR6
46 egg allergy 10.5 IL4 IL10 CCR6
47 hypopyon 10.5 TNF IL10 CD4
48 type 1 diabetes mellitus 23 10.5 TNF CD8A CD4
49 chest wall lymphoma 10.5 IGHV4-38-2 CCR6
50 anus cancer 10.5 H2AC18 CD8A CD4

Graphical network of the top 20 diseases related to Splenic Disease:



Diseases related to Splenic Disease

Symptoms & Phenotypes for Splenic Disease

UMLS symptoms related to Splenic Disease:


hepatosplenomegaly

MGI Mouse Phenotypes related to Splenic Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.17 ALB CCR6 CD19 CD4 CD5 CD8A
2 hematopoietic system MP:0005397 10.15 CCR6 CD19 CD4 CD5 CD8A IFNG
3 digestive/alimentary MP:0005381 10.1 ALB CD19 CD4 F2 IFNG IL10
4 integument MP:0010771 9.96 CD19 CD4 CD5 CD8A F2 IFNG
5 neoplasm MP:0002006 9.7 ALB CD19 IFNG IL10 IL2 SLC11A1
6 no phenotypic analysis MP:0003012 9.5 CD4 CD5 IFNG IL10 IL2 IL4
7 normal MP:0002873 9.32 ALB CCR6 CD19 CD4 CD5 CD8A

Drugs & Therapeutics for Splenic Disease

Search Clinical Trials , NIH Clinical Center for Splenic Disease

Inferred drug relations via UMLS 70 / NDF-RT 51 :


alglucerase
imiglucerase

Cochrane evidence based reviews: splenic diseases

Genetic Tests for Splenic Disease

Genetic tests related to Splenic Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Spleen 29

Anatomical Context for Splenic Disease

MalaCards organs/tissues related to Splenic Disease:

40
Spleen, Lymph Node, Liver, Bone Marrow, Bone, Ovary

Publications for Splenic Disease

Articles related to Splenic Disease:

(show top 50) (show all 227)
# Title Authors PMID Year
1
Sarcopenia is a useful risk stratification tool to prognosticate splenic abscess patients in the emergency department. 42
32917483 2021
2
Risk of invasive pneumococcal disease in patients with asplenia/hyposplenism: A nationwide population-based study in Korea, 2009-2018. 42
32663603 2020
3
Laboratory results and clinical findings of children with hydatid cyst disease. 42
32620733 2020
4
Hemoperitoneum due to splenic injury after colonoscopy, a complication perhaps not so uncommon. 61
33486966 2021
5
Partial Splenectomy for a Sizeable Cavernous Hemangioma: Case Report and a Review of the Literature. 61
33633911 2021
6
Conventional Ultrasound and Contrast-Enhanced Ultrasound in the Diagnosis of Splenic Diseases: A Systematic Review and Meta-analysis. 61
32323353 2020
7
Radiological Society of North America (RSNA) 3D Printing Special Interest Group (SIG) clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: abdominal, hepatobiliary, and gastrointestinal conditions. 61
32514795 2020
8
Splenic lymphangioma in adulthood: A case report. 61
32086147 2020
9
Comparison of early postoperative results between robot-assisted and laparoscopic splenectomy for non-traumatic splenic diseases rather than portal hypertensive hypersplenism-a meta-analysis. 61
31350089 2020
10
Laparoscopic near-total splenectomy. Report of a case. 61
33191191 2020
11
Administration of certain sedative drugs is associated with variation in sonographic and radiographic splenic size in healthy cats. 61
31368224 2019
12
Diagnostic and Clinical Impact of Staging 18F-FDG PET/CT in Mantle-Cell Lymphoma: A Two-Center Experience. 61
31129112 2019
13
Splenic mass diagnosis in dogs undergoing splenectomy according to breed size. 61
31040215 2019
14
The forensic spleen: Morphological, radiological, and toxicological investigations. 61
30803735 2019
15
Spontaneous Splenic Rupture following Colorectal Surgery and Hemodialysis. 61
31321113 2019
16
The forensic spleen: Morphological, radiological, and toxicological investigations. 61
30173072 2018
17
Magnetic resonance elastography of liver and spleen: Methods and applications. 61
29369503 2018
18
Complications and short-term outcomes associated with single-port laparoscopic splenectomy in dogs. 61
29178506 2018
19
Early detection and integral resection are keys to extend survival in patients suffered from primary angiosarcoma of the spleen: A care-compliant case report and literature review. 61
29384853 2018
20
Anatomic variations of the spleen: current state of terminology, classification, and embryological background. 61
28631052 2018
21
Clinical features and prognostic significance of splenic involvement in sarcoidosis. 61
29424195 2017
22
Laparoscopic splenectomy for sclerosing angiomatoid nodular transformation of the spleen. 61
28695885 2017
23
Splenomegaly in small-breed dogs: 45 cases(2005-2011). 61
28467747 2017
24
Molecular detection of vector-borne pathogens in blood and splenic samples from dogs with splenic disease. 61
28285583 2017
25
Cystic lymphangioma of spleen in adults. 61
28122799 2017
26
A case of splenic metastasis of ovarian cancer treated with complete laparoscopic splenectomy and transvaginal specimen extraction. 61
26976616 2016
27
Splenic injury following elective colonoscopy: a rare complication. 61
28003318 2016
28
No evidence of splenic disease in patients with splenic marginal zone lymphoma undergoing splenectomy for autoimmune hemolytic anemia after monotherapy with rituximab. 61
27082039 2016
29
Correlation of pre-operative CT findings with surgical & histological tumor dissemination patterns at cytoreduction for primary advanced and relapsed epithelial ovarian cancer: A retrospective evaluation. 61
27586894 2016
30
Sonographic Bands of Hypoechogenicity in the Spleen in Children: Zebra Spleen. 61
27305585 2016
31
Splenic Cysts. 61
27403673 2016
32
Occurrence and Clinicopathologic Features of Splenic Neoplasia Based on Body Weight: 325 Dogs (2003-2013). 61
27259024 2016
33
[Non-traumatic arteriovenous malformation of the spleen with fatal hemorrhage]. 61
27223590 2016
34
Single-site multiport combined splenectomy and cholecystectomy with conventional laparoscopic instruments: Case series and review of literature. 61
26708949 2016
35
Histopathological correlation of splenic disease with radiological and surgical findings: should we incorporate splenectomy into standard procedures for disseminated Millerian adenocarcinoma? 61
29787010 2016
36
Experience with Extra Hepatic Intra Abdominal Hydatid Cyst. 61
27746469 2015
37
Correction: In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosmiasis. 61
26474175 2015
38
In Vivo MRI Assessment of Hepatic and Splenic Disease in a Murine Model of Schistosomiasis [corrected]. 61
26394390 2015
39
Non-traumatic splenic rupture on dual antiplatelet therapy with aspirin and ticagrelor after stenting for acute coronary syndrome. 61
30524542 2015
40
Clinical significance of single-port laparoscopic splenectomy: comparison of single-port and multiport laparoscopic procedure. 61
26236693 2015
41
Short-Term Outcome of Multiple Port Laparoscopic Splenectomy in 10 Dogs. 61
25522804 2015
42
Acoustic radiation force impulse (ARFI) elastography of the spleen in healthy adult cats--a preliminary study. 61
25482989 2015
43
Nonneoplastic, benign, and malignant splenic diseases: cross-sectional imaging findings and rare disease entities. 61
25055265 2014
44
Ultrasonography of the spleen. Pictorial essay. 61
24567925 2014
45
Perioperative outcomes of laparoscopic versus open splenectomy for nontraumatic diseases: a meta-analysis. 61
24985592 2014
46
Juvenile myelomonocytic leukemia: molecular pathogenesis informs current approaches to therapy and hematopoietic cell transplantation. 61
24734223 2014
47
Effect of two sedative protocols and hepatosplenic disease on Doppler indices of splenic arteries in dogs: a preliminary study. 61
23623458 2013
48
Dynamic contrast-enhanced MRI improves accuracy for detecting focal splenic involvement in children and adolescents with Hodgkin disease. 61
23377561 2013
49
Simultaneous synthesis and amine-functionalization of single-phase BaYF5:Yb/Er nanoprobe for dual-modal in vivo upconversion fluorescence and long-lasting X-ray computed tomography imaging. 61
23715609 2013
50
Laparoscopic splenectomy: a single center experience. Unusual cases and expanded inclusion criteria for laparoscopic approach. 61
23355349 2013

Variations for Splenic Disease

Expression for Splenic Disease

Search GEO for disease gene expression data for Splenic Disease.

Pathways for Splenic Disease

Pathways related to Splenic Disease according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 TNF THPO IL4 IL2 IL10 IFNG
2
Show member pathways
13.52 TNF THPO IL4 IL2 IL10 IFNG
3
Show member pathways
13.28 TNF THPO IL4 IL2 IL10 CD4
4
Show member pathways
12.83 TNF IL4 IL2 IL10 IFNG CD8A
5
Show member pathways
12.64 TNF IL4 IL2 IL10 IFNG CD4
6
Show member pathways
12.6 TNF IL4 IL2 IL10 IFNG CD4
7
Show member pathways
12.58 TNF IL2 IL10 IFNG F2 CD4
8
Show member pathways
12.56 TNF IL4 IL2 IL10 IFNG CD8A
9 12.49 TNF IL4 IL2 IL10 IFNG CD8A
10
Show member pathways
12.41 THPO IL4 IL2 IL10 IFNG
11
Show member pathways
12.31 TNF IL2 IL10 CCR6
12
Show member pathways
12.3 TNF IL4 IL2 IFNG F2 ALB
13
Show member pathways
12.26 TNF THPO IL4 IL2 IL10 IFNG
14
Show member pathways
12.24 TNF IL4 IL10 IFNG
15 12.07 TNF IL2 IL10 CD8A CD4
16 12 TNF IL4 IL2 IFNG
17
Show member pathways
11.98 IL4 IL2 IFNG CD8A CD4
18 11.86 TNF THPO IL4 CD8A CD5 CD4
19
Show member pathways
11.78 TNF IL4 IL2 IFNG
20 11.71 TNF IL4 IL10 CCR6
21
Show member pathways
11.68 TNF IL2 IL10 IFNG CD4
22 11.67 TNF IL2 IL10 IFNG CD8A CD4
23
Show member pathways
11.64 TNF IL2 IFNG
24
Show member pathways
11.64 TNF IL2 IFNG CD8A
25 11.54 TNF IL2 IFNG
26 11.53 TNF IL10 IFNG
27 11.52 TNF IL4 IL10
28 11.5 TNF IL2 IFNG
29 11.46 TNF IL4 IL2 IL10 IFNG CD8A
30 11.43 IL4 IL2 IL10 IFNG CD4
31 11.4 CD8A CD4 CD19
32 11.39 TNF THPO IL4 IL2 IL10 IFNG
33 11.38 TNF IL10 IFNG
34
Show member pathways
11.37 TNF IL2 IL10 IFNG
35 11.33 IL4 IL2 IFNG
36 11.31 TNF IL4 IFNG
37 11.24 IL2 IFNG CD4
38 11.17 IL4 IL2 IL10 IFNG
39 11.1 TNF IL4 IL2 IL10 IFNG CD4

GO Terms for Splenic Disease

Cellular components related to Splenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNF THPO IL4 IL2 IL10 IFNG
2 external side of plasma membrane GO:0009897 9.23 TNF IGHV4-38-2 F2 CD8A CD5 CD4

Biological processes related to Splenic Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.03 IL2 IFNG CD8A CD4 CD19
2 cytokine-mediated signaling pathway GO:0019221 9.92 TNF IL4 IL2 IL10 CD4
3 positive regulation of interferon-gamma production GO:0032729 9.79 TNF SLC11A1 IL2
4 positive regulation of T cell proliferation GO:0042102 9.78 IL4 IL2 CD4
5 humoral immune response GO:0006959 9.77 TNF IFNG CCR6
6 positive regulation of phagocytosis GO:0050766 9.72 TNF SLC11A1 IFNG
7 T cell activation GO:0042110 9.71 IL4 CD8A CD4
8 negative regulation of T-helper 17 cell differentiation GO:2000320 9.63 IL4 IL2
9 positive regulation of JAK-STAT cascade GO:0046427 9.63 TNF IL10 F2
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.62 IL4 IL2
11 endothelial cell apoptotic process GO:0072577 9.62 TNF IL10
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 TNF IL4 IL2 IFNG
13 microglial cell activation GO:0001774 9.61 TNF IL4 IFNG
14 positive regulation of mononuclear cell migration GO:0071677 9.59 TNF IL4
15 negative regulation of cytokine production involved in immune response GO:0002719 9.58 TNF IL10
16 positive regulation of cellular respiration GO:1901857 9.58 IL4 IFNG
17 neuroinflammatory response GO:0150076 9.57 IL4 IFNG
18 type 2 immune response GO:0042092 9.56 IL4 IL10
19 positive regulation of cytokine production GO:0001819 9.56 TNF SLC11A1 IL10 IFNG
20 positive regulation of plasma cell differentiation GO:1900100 9.51 IL2 IL10
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 TNF IFNG
22 regulation of isotype switching GO:0045191 9.48 IL4 IL10
23 positive regulation of protein phosphorylation GO:0001934 9.43 TNF THPO IL2 IFNG F2 CD4
24 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 TNF IFNG
25 positive regulation of nitrogen compound metabolic process GO:0051173 9.37 TNF IFNG
26 positive regulation of MHC class II biosynthetic process GO:0045348 9.33 IL4 IL10 IFNG
27 immune response GO:0006955 9.28 TNF SLC11A1 IL4 IL2 IL10 IFNG

Molecular functions related to Splenic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 THPO IL4 IL2 IL10 F2
2 cytokine activity GO:0005125 9.1 TNF THPO IL4 IL2 IL10 IFNG

Sources for Splenic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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