MCID: SPL003
MIFTS: 28

Splenic Flexure Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Splenic Flexure Cancer

MalaCards integrated aliases for Splenic Flexure Cancer:

Name: Splenic Flexure Cancer 12 15
Malignant Neoplasm of Splenic Flexure of Colon 70
Malignant Neoplasm of Splenic Flexure 12
Malignant Tumor of Splenic Flexure 12
Ca Splenic Flexure - Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12191
ICD9CM 34 153.7
SNOMED-CT 67 94072004
ICD10 32 C18.5
UMLS 70 C0153440

Summaries for Splenic Flexure Cancer

MalaCards based summary : Splenic Flexure Cancer, also known as malignant neoplasm of splenic flexure of colon, is related to testicular sex cord-stromal neoplasm and testicular leydig cell tumor. An important gene associated with Splenic Flexure Cancer is GAD2 (Glutamate Decarboxylase 2), and among its related pathways/superpathways are Glucose / Energy Metabolism and Peptide hormone metabolism. Affiliated tissues include colon, liver and lymph node.

Related Diseases for Splenic Flexure Cancer

Diseases related to Splenic Flexure Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 testicular sex cord-stromal neoplasm 10.1 SLC5A4 SLC5A2
2 testicular leydig cell tumor 10.1 SLC5A4 SLC5A2
3 vulvitis 10.1 SLC5A4 SLC5A2
4 chicken egg allergy 10.1 SLC5A4 SLC5A2
5 penile disease 10.1 SLC5A4 SLC5A2
6 autoimmune polyendocrine syndrome, type ii 10.1 INS GAD2
7 autoimmune polyendocrine syndrome 10.1 INS GAD2
8 acute pancreatitis 10.0
9 adenosquamous bile duct carcinoma 10.0 GCG DPP4
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 INS GAD2
11 barre-lieou syndrome 10.0 GCG DPP4
12 adrenal cortical hypofunction 10.0 INS GAD2
13 type 1 diabetes mellitus 2 10.0 INS GAD2
14 stiff-person syndrome 10.0 INS GAD2
15 brachydactyly, type c 10.0 INS GAD2
16 postgastrectomy syndrome 10.0 INS GCG
17 autoimmune disease of endocrine system 10.0 INS GAD2
18 acute insulin response 10.0 INS GCG
19 functional gastric disease 10.0 INS GCG
20 pancreatic endocrine carcinoma 10.0 INS GCG
21 diabetic autonomic neuropathy 10.0 INS GCG
22 autonomic neuropathy 10.0 INS GCG
23 dumping syndrome 10.0 INS GCG
24 somatostatinoma 10.0 INS GCG
25 autonomic nervous system disease 9.9 INS GCG
26 apnea, obstructive sleep 9.9 INS GCG
27 fanconi syndrome 9.9 SLC5A4 SLC5A2
28 intermediate coronary syndrome 9.9 INS DPP4
29 glycogen storage disease ia 9.9 INS GCG
30 maturity-onset diabetes of the young, type 3 9.9 INS GCG
31 pancreatic agenesis 9.9 INS GCG
32 islet cell tumor 9.9 INS GCG
33 mental depression 9.9 INS DPP4
34 balanoposthitis 9.9 SLC5A4 SLC5A2 DPP4
35 trigonitis 9.9 SLC5A4 SLC5A2 DPP4
36 vulvovaginitis 9.9 SLC5A4 SLC5A2 DPP4
37 pituitary gland disease 9.8 INS GCG
38 liver lipoma 9.8 INS CEACAM5
39 carbohydrate metabolic disorder 9.8 INS GCG
40 silent myocardial infarction 9.8 SLC5A4 SLC5A2 INS
41 pyelitis 9.8 SLC5A4 SLC5A2 INS
42 renal glucosuria 9.8 SLC5A4 SLC5A2 INS
43 middle east respiratory syndrome 9.8 DPP4 CEACAM5
44 type 1 diabetes mellitus 9.7 INS GCG GAD2
45 abdominal obesity-metabolic syndrome 1 9.7 INS GCG
46 hypoglycemic coma 9.7 INS GCG DPP4
47 maturity-onset diabetes of the young, type 1 9.7 INS GCG DPP4
48 prediabetes syndrome 9.7 INS GCG DPP4
49 autoimmune disease 9.7 INS GAD2 DPP4
50 glucose intolerance 9.7 INS GCG DPP4

Comorbidity relations with Splenic Flexure Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Colorectal Cancer
Deficiency Anemia Intestinal Obstruction
Paralytic Ileus

Graphical network of the top 20 diseases related to Splenic Flexure Cancer:



Diseases related to Splenic Flexure Cancer

Symptoms & Phenotypes for Splenic Flexure Cancer

Drugs & Therapeutics for Splenic Flexure Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aberrant Lympahtic Drainage of Splenic Flexure Cancer: Are Splenic Hilar Nodes Metastases an Underecognized Phenomenon? Not yet recruiting NCT04666883

Search NIH Clinical Center for Splenic Flexure Cancer

Genetic Tests for Splenic Flexure Cancer

Anatomical Context for Splenic Flexure Cancer

MalaCards organs/tissues related to Splenic Flexure Cancer:

40
Colon, Liver, Lymph Node, Spleen, Pancreas, Kidney, Thyroid

Publications for Splenic Flexure Cancer

Articles related to Splenic Flexure Cancer:

(show all 35)
# Title Authors PMID Year
1
Surgical anatomy of the accessory middle colic artery: a meta-analysis with implications for splenic flexure cancer surgery. 61
33721386 2021
2
Evaluation of vascular anatomy for colon cancer located in the splenic flexure using the preoperative three-dimensional computed tomography angiography with colonography. 61
33047209 2021
3
Re-interpreting mesenteric vascular anatomy on 3D virtual and/or physical models: positioning the middle colic artery bifurcation and its relevance to surgeons operating colon cancer. 61
33492511 2021
4
Laparoscopic Colectomy for Splenic Flexure Cancer Approached from Four Directions. 61
33226876 2020
5
Haemorrhagic shock secondary to non-traumatic spleen rupture as a manifestation of splenic flexure cancer: A case report. 61
32418759 2020
6
Segmental Colonic Resection Is a Safe and Effective Treatment Option for Colon Cancer of the Splenic Flexure: A Nationwide Retrospective Study of the Italian Society of Surgical Oncology-Colorectal Cancer Network Collaborative Group. 61
32969880 2020
7
Colonic splenic flexure carcinoma: is laparoscopic segmental resection a safe enough oncological approach? 61
31617095 2020
8
Laparoscopic resection with complete mesocolic excision for splenic flexure cancer: long-term follow-up data from a multicenter retrospective study. 61
31451917 2020
9
Segmental Colonic Resection is a Safe and Effective Treatment Option for Colon Cancer of the Splenic Flexure: A Nationwide Retrospective Study of the Italian Society of Surgical Oncology-Colorectal Cancer Network Collaborative Group. 61
32732532 2020
10
Surgical treatment of a colon neoplasm of the splenic flexure: a multicentric study of short-term outcomes. 61
31454443 2020
11
Robotic colon resection for splenic flexure cancer with intracorporeal anastomosis (with video). 61
31324534 2020
12
Laparoscopic en bloc resection of T4b splenic flexure cancer with infiltration of the stomach and tail of the pancreas - a video vignette. 61
31549470 2020
13
Laparoscopic segmental left colectomy for splenic flexure carcinoma: a single institution experience. 61
31834555 2020
14
Robotic left colectomy with complete mesocolic excision and intracorporeal side-to-side anastomosis for splenic flexure cancer with the da Vinci Xi robotic platform - a video vignette. 61
31390679 2019
15
Does transverse colon cancer spread to the extramesocolic lymph node stations? 61
31701816 2019
16
Evaluation of the venous drainage pattern of the splenic flexure by preoperative three-dimensional computed tomography. 61
30358131 2019
17
Laparoscopic Complete Mesocolic Excision for Double Flexural Colon Cancers. 61
30927197 2019
18
Treatment of splenic flexure colon cancer: a comparison of three different surgical procedures: Experience of a high volume cancer center. 61
31358904 2019
19
Arterial anatomy of the splenic flexure using preoperative three-dimensional computed tomography. 61
30955075 2019
20
Is Segmental Colon Resection an Alternative Treatment for Splenic Flexure Cancer? 61
30950767 2019
21
How to do a laparoscopic high left colectomy with complete mesocolic excision and central vascular ligation for splenic flexure cancer. 61
30953397 2019
22
How we do it: totally laparoscopic complete mesocolon excision for splenic flexure cancer. 61
30083837 2018
23
Intracorporeal versus extracorporeal anastomosis after laparoscopic left colectomy for splenic flexure cancer: results from a multi-institutional audit on 181 consecutive patients. 61
29344788 2018
24
Lymphatic Drainage of the Splenic Flexure Defined by Intraoperative Scintigraphic Mapping. 61
29521825 2018
25
Anatomical and embryological perspectives in laparoscopic complete mesocoloic excision of splenic flexure cancers. 61
28812159 2018
26
Comparison of long-term outcomes after laparoscopic-assisted and open colectomy for splenic flexure cancer. 61
29745072 2018
27
Iatrogenic diaphragmatic hernia following laparoscopic left colectomy for splenic flexure cancer An unusual complication. 61
28232645 2016
28
Laparoscopic colonic resection for splenic flexure cancer: our experience. 61
26148781 2015
29
Survival after resection of colorectal cancer based on anatomical segment of involvement. 61
24046100 2013
30
A nationwide Danish cohort study challenging the categorisation into right-sided and left-sided colon cancer. 61
23793665 2013
31
Surgical treatment and subsequent outcome of patients with carcinoma of the splenic flexure. 61
11318121 2001
32
Carcinoma of the splenic flexure: multivariate analysis of predictive factors for clinicopathological characteristics and outcome after surgery. 61
10905361 2000
33
[Amplifying right colectomy: place in the treatment of obstructive proximal left colon cancer]. 61
10668270 1999
34
[Carcinoma of the splenic flexure. Nosological and therapeutic contribution]. 61
9272977 1996
35
Survival after resection of carcinoma of the splenic flexure. 61
2022146 1991

Variations for Splenic Flexure Cancer

Expression for Splenic Flexure Cancer

Search GEO for disease gene expression data for Splenic Flexure Cancer.

Pathways for Splenic Flexure Cancer

GO Terms for Splenic Flexure Cancer

Biological processes related to Splenic Flexure Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of insulin secretion GO:0050796 8.62 GCG DPP4

Molecular functions related to Splenic Flexure Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose:sodium symporter activity GO:0005412 8.62 SLC5A4 SLC5A2

Sources for Splenic Flexure Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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