MCID: SPL006
MIFTS: 35

Splenic Infarction

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Splenic Infarction

MalaCards integrated aliases for Splenic Infarction:

Name: Splenic Infarction 12 55 44 15 73
Infarct of the Spleen 53
Splenic Infarcts 53
Splenic Infarct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2533
ICD10 33 D73.5
MeSH 44 D013159
UMLS 73 C0037998

Summaries for Splenic Infarction

MalaCards based summary : Splenic Infarction, also known as infarct of the spleen, is related to endocarditis and infective endocarditis. An important gene associated with Splenic Infarction is HBB (Hemoglobin Subunit Beta). The drugs Heparin and Anticoagulants have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and myeloid.

Wikipedia : 76 Splenic infarction is a condition in which oxygen supply to the spleen is interrupted, leading to... more...

Related Diseases for Splenic Infarction

Diseases related to Splenic Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 endocarditis 30.2 APOH F2
2 infective endocarditis 30.2 APOH F2
3 thrombophilia due to thrombin defect 29.9 APOH F2
4 thrombosis 29.8 APOH F2
5 antiphospholipid syndrome 29.8 APOH F2
6 portal vein thrombosis 29.7 APOH F2
7 sickle cell anemia 29.6 F2 HBB
8 hemolytic anemia 29.5 APOH HBB PIEZO1
9 pulmonary embolism 29.3 APOH F2
10 purpura 29.1 APOH F2
11 hemoglobin e disease 10.4 F2 HBB
12 splenic disease 10.3 F2 HBB
13 spinal cord infarction 10.3 APOH F2
14 livedoid vasculopathy 10.3 APOH F2
15 cerebral sinovenous thrombosis 10.3 APOH F2
16 prothrombin deficiency, congenital 10.3 APOH F2
17 ischemic colitis 10.3 APOH F2
18 papilledema 10.3 APOH F2
19 sneddon syndrome 10.3 APOH F2
20 retinal artery occlusion 10.3 APOH F2
21 buerger disease 10.3 APOH F2
22 hepatic infarction 10.3 APOH F2
23 retinal vascular occlusion 10.3 APOH F2
24 thrombophlebitis 10.3 APOH F2
25 prothrombin deficiency 10.3 APOH F2
26 antithrombin iii deficiency 10.3 APOH F2
27 peripheral vertigo 10.3 APOH F2
28 central retinal vein occlusion 10.2 APOH F2
29 branch retinal artery occlusion 10.2 APOH F2
30 protein s deficiency 10.2 APOH F2
31 placental abruption 10.2 APOH F2
32 ischemic optic neuropathy 10.2 APOH F2
33 intracranial hypertension 10.2 APOH F2
34 intermittent claudication 10.2 APOH F2
35 retinal vein occlusion 10.1 APOH F2
36 pancreatitis 10.1
37 thrombophilia due to activated protein c resistance 10.1 APOH F2
38 malaria 10.1
39 budd-chiari syndrome 10.1 APOH F2
40 hereditary spherocytosis 10.0
41 aneurysm 10.0
42 leukemia 9.9
43 acute pancreatitis 9.9
44 immune system disease 9.9 APOH F2 HBB
45 anemia, autoimmune hemolytic 9.9
46 polycythemia vera 9.9
47 hepatitis 9.9
48 peritonitis 9.9
49 polycythemia 9.9
50 thrombocytopenia 9.8

Graphical network of the top 20 diseases related to Splenic Infarction:



Diseases related to Splenic Infarction

Symptoms & Phenotypes for Splenic Infarction

Drugs & Therapeutics for Splenic Infarction

Drugs for Splenic Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
2 Anticoagulants Phase 2
3 calcium heparin Phase 2
4 Calcium, Dietary Phase 2
5 Fibrinolytic Agents Phase 2
6 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HEROIC (Heparin Requirement in Counterpulsation) Terminated NCT00445211 Phase 2 Heparin
2 Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584 Not Applicable

Search NIH Clinical Center for Splenic Infarction

Cochrane evidence based reviews: splenic infarction

Genetic Tests for Splenic Infarction

Anatomical Context for Splenic Infarction

MalaCards organs/tissues related to Splenic Infarction:

41
Spleen, Liver, Myeloid, B Cells

Publications for Splenic Infarction

Articles related to Splenic Infarction:

(show top 50) (show all 311)
# Title Authors Year
1
Acute Gastritis and Splenic Infarction Caused by Epstein-Barr Virus. ( 29713613 )
2018
2
Lessons learned from splenic infarcts with fever of unknown origin (FUO): culture-negative endocarditis (CNE) or malignancy? ( 29417312 )
2018
3
A case of complete splenic infarction after laparoscopic spleen-preserving distal pancreatectomy. ( 29636057 )
2018
4
A Case of Scrub Typhus complicated with a Splenic Infarction. ( 29637756 )
2018
5
Splenic Infarction: An Under-recognized Complication of Infectious Mononucleosis? ( 29577060 )
2018
6
Long-term follow up of a massive, conservatively treated, splenic infarction in a young adolescent. ( 29044906 )
2017
7
Ischemic Necrosis of the Gastric Remnant without Splenic Infarction Following Subtotal Gastrectomy. ( 28835094 )
2017
8
Acute Pancreatitis with Splenic Infarction as Early Postoperative Complication following Laparoscopic Sleeve Gastrectomy. ( 28487807 )
2017
9
Splenic Infarction as a Delayed Febrile Complication Following Radical Gastrectomy for Gastric Cancer Patients: Computed Tomography-Based Analysis. ( 29270657 )
2017
10
Splenic infarction due a common infection. ( 29078991 )
2017
11
A case of cytomegalovirus infection with splenic infarction and an esophageal ulcer in an immunocompetent adult. ( 28679983 )
2017
12
Image Diagnosis: Splenic Infarction Associated with Oral Contraceptive Pills in a Healthy Young Woman. ( 28488992 )
2017
13
Splenic Infarction as Starting Symptom in Minimal Change Nephropathy. ( 28229998 )
2017
14
Streptococcus agalactiae infective endocarditis complicated by multiple mycotic hepatic aneurysms and massive splenic infarction: a case report. ( 29284415 )
2017
15
Transient antiphospholipid syndrome and splenic infarction in a patient with parvovirus B19 acute infection. ( 28602215 )
2017
16
AN UNUSUAL CAUSE OF ACUTE ABDOMEN: SPLENIC INFARCTION. ( 29340557 )
2017
17
Splenic Infarction in Two Members of the Family with Sickle Cell Trait: A Case Report of Rare Complication. ( 29308370 )
2017
18
Splenic Infarction and Rupture Due to Melioidosis. ( 29208262 )
2017
19
Splenic infarction associated with acute infectious mononucleosis. ( 28480876 )
2017
20
Spontaneous Splenic Infarcts in a Cirrhotic Patient with Primary Biliary Cirrhosis. ( 28203139 )
2017
21
Pulmonary arteriovenous malformations complicated by splenic infarction and abscess. ( 28736615 )
2017
22
Sequential Insults: Acute Lyme Disease with Splenic Infarction. ( 26688425 )
2016
23
A Case of Isolated Celiac Artery Dissection Accompanied by Splenic Infarction Detected by Ultrasonography in the Emergency Department. ( 27148460 )
2016
24
Splenic Infarction in Acute Infectious Mononucleosis. ( 26602427 )
2016
25
Massive splenic infarction and splenic venous thrombosis observed in a patient with acute splenic syndrome of sickle cell traits on contrast-enhanced thin-slice computed tomography. ( 27251735 )
2016
26
Splenic infarction as a pitfall on labeled red blood cell imaging. ( 26917904 )
2016
27
Splenic infarction associated with acute infectious mononucleosis due to Epstein-Barr virus infection. ( 27357912 )
2016
28
Group B Streptococcal Tricuspid Valve Endocarditis with Splenic Infarction after an Elective Abortion. ( 27617630 )
2016
29
Dangerous proximity: splenic infarction after abdominal abscess. ( 25448176 )
2015
30
A Diagnostic Pitfall: Salmonella Splenic Infarction in Hereditary Spherocytosis. ( 26272774 )
2015
31
The unexpected finding of a splenic infarction in a patient with infectious mononucleosis due to Epstein-Barr virus. ( 26607191 )
2015
32
An adolescent with hereditary spherocytosis who presented with splenic infarction. ( 26139647 )
2015
33
Mycosis fungoides associated with splenic infarction and muscle involvement. ( 25994394 )
2015
34
Splenic infarction after reversal of warfarin using Prothrombinex-VF in a patient with a mechanical aortic valve. ( 26224191 )
2015
35
Brachial artery mycotic aneurysm and splenic infarction associated with infective endocarditis. ( 26186921 )
2015
36
Evaluation with contrast ultrasound of the prevalence of splenic infarction in left-sided infective endocarditis. ( 26261464 )
2015
37
Splenic infarction associated with sickle cell trait at low altitude. ( 26133225 )
2015
38
Acute Splenic Infarction at an Academic General Hospital Over 10 Years: Presentation, Etiology, and Outcome. ( 26356690 )
2015
39
Splenic infarction - A rare cause of acute abdominal pain following gastric surgery: A case series. ( 25818369 )
2015
40
Incidentally Discovered Splenic Infarction Associated with Scrub Typhus. ( 26333728 )
2015
41
Splenic infarction and G-CSF. ( 26840787 )
2015
42
Splenic Infarction in Polycythemia Vera: Can the Spleen be Saved? ( 26731841 )
2015
43
Massive splenic infarction leading to sickle cell disease. ( 25075666 )
2014
44
Splenic infarction in Plasmodium vivax malaria. ( 24825280 )
2014
45
Malaria-Induced Splenic Infarction. ( 25294615 )
2014
46
Spontaneous massive splenic infarction in the setting of renal transplant and septic shock: a case report and review of the literature. ( 25317176 )
2014
47
A novel frameshift mutation in exon 4 causing a deficiency of high-molecular-weight kininogen in a patient with splenic infarction. ( 24492696 )
2014
48
Massive splenic infarction and portal vein thrombosis in children with chronic myeloid leukemia. ( 24942025 )
2014
49
Splenic infarction caused by a rare coinfection of Epstein-Barr virus, cytomegalovirus, and Mycoplasma pneumoniae. ( 25186505 )
2014
50
Splenic infarction due to disseminated primary CMV infection. ( 25159098 )
2014

Variations for Splenic Infarction

Expression for Splenic Infarction

Search GEO for disease gene expression data for Splenic Infarction.

Pathways for Splenic Infarction

GO Terms for Splenic Infarction

Biological processes related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation, intrinsic pathway GO:0007597 9.26 APOH F2
2 positive regulation of blood coagulation GO:0030194 9.16 APOH F2
3 regulation of blood coagulation GO:0030193 8.96 APOH F2
4 negative regulation of fibrinolysis GO:0051918 8.62 APOH F2

Sources for Splenic Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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