Splenic Infarction disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPL006 MIFTS: 34	Splenic Infarction Categories: Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Splenic Infarction

MalaCards integrated aliases for Splenic Infarction:

Name: Splenic Infarction ¹² ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Infarct of the Spleen ⁵³

Splenic Infarcts ⁵³

Splenic Infarct ¹²

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other diseases of blood and blood-forming organs

Diseases of spleen

Infarction of spleen

External Ids:

Disease Ontology ¹² DOID:2533

ICD10 ³³ D73.5

MeSH ⁴⁴ D013159

SNOMED-CT ⁶⁸ 22996003

UMLS ⁷³ C0037998

Sources

Summaries for Splenic Infarction

MalaCards based summary : Splenic Infarction, also known as infarct of the spleen, is related to hemolytic anemia and thrombosis. An important gene associated with Splenic Infarction is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Selenium Micronutrient Network and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Heparin and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and myeloid.

Wikipedia : ⁷⁶ Splenic infarction is a condition in which oxygen supply to the spleen is interrupted, leading to... more...

Sources

Related Diseases for Splenic Infarction

Diseases related to Splenic Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)

#	Related Disease	Score	Top Affiliating Genes
1	hemolytic anemia	29.7	HBB PIEZO1
2	thrombosis	10.3
3	endocarditis	10.3
4	malaria	10.2
5	pancreatitis	10.2
6	infective endocarditis	10.1
7	hereditary spherocytosis	10.1
8	acute pancreatitis	10.1
9	viral infectious disease	10.1
10	thrombophilia due to thrombin defect	10.0
11	anemia, autoimmune hemolytic	10.0
12	polycythemia vera	10.0
13	lymphoma	10.0
14	peritonitis	10.0
15	polycythemia	10.0
16	sickle cell disease	10.0
17	systemic lupus erythematosus	9.9
18	sickle cell anemia	9.9
19	polyarteritis nodosa, childhood-onset	9.9
20	leukemia	9.9
21	thrombocytopenia	9.9
22	splenic sequestration	9.9
23	plasmodium vivax malaria	9.9
24	scrub typhus	9.9
25	hemoglobin c disease	9.9
26	antiphospholipid syndrome	9.9
27	protein c deficiency	9.9
28	lupus erythematosus	9.9
29	pulmonary embolism	9.9
30	polyarteritis nodosa	9.9
31	splenomegaly	9.9
32	cytomegalovirus infection	9.9
33	congenital hemolytic anemia	9.9	HBB PIEZO1
34	pfeiffer syndrome	9.9
35	pancreatic cancer	9.9
36	granulomatosis with polyangiitis	9.9
37	gastric cancer	9.9
38	b-cell lymphomas	9.9
39	paroxysmal nocturnal hemoglobinuria	9.9
40	thalassemia	9.9
41	lymphocytic leukemia	9.9
42	portal hypertension	9.9
43	gastric ulcer	9.9
44	brucellosis	9.9
45	q fever	9.9
46	splenic artery aneurysm	9.9
47	toxic shock syndrome	9.9
48	splenic abscess	9.9
49	subacute bacterial endocarditis	9.9
50	hemoglobinuria	9.9

Graphical network of the top 20 diseases related to Splenic Infarction:

Sources

Symptoms & Phenotypes for Splenic Infarction

Sources

Drugs & Therapeutics for Splenic Infarction

Drugs for Splenic Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Heparin

Approved, Investigational

Phase 2

9005-49-6

772 46507594

Synonyms:

101921-26-0

102785-31-9

102-94-3

104521-37-1

11078-24-3

11129-39-8

12656-11-0

37324-73-5

9041-08-1

9045-22-1

9075-96-1

913079-23-9

91449-79-5

AC1L1ROY

ALFA 87-120

ALFA 87-163

ALFA 87-198

ALFA 87-81

ALFA 88-247

Allocinnamic acid

alpha-Heparin

Alpha-Heparin

Ardeparin

Ardeparin sodium

Ariven

Arteven

Bemiparin

Bemiparin sodium

Calcilean

Calciparine

Certoparin

CID8784

cis-.beta.-Carboxystyrene

cis-Cinnamic acid

Clexane

Clivarin

Clivarine

CY 216

Cy 222

Dalteparin

Dalteparin sodium

Depo-Heparin

EINECS 232-681-7

Enoxaparin

Enoxaparin sodium

Eparina

Eparina [DCIT]

Fluxum

FR 860

Fragmin A

Fragmin B

Fragmin IV

Fraxiparin

H 2149

Hed-heparin

Hed-Heparin

Hep Flush Kit in plastic container

Hepalean

heparin

Heparin Cy 216

Heparin CY 216

Heparin Leo

Heparin Lock Flush

Heparin Lock Flush in plastic container

Heparin Lock Flush preservative free

Heparin Lock Flush preservative free in plastic container

Heparin natrium

Heparin sodium

Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container

Heparin sodium 1,000 units in dextrose 5% in plastic container

Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container

Heparin sodium 10,000 units in dextrose 5%

Heparin sodium 10,000 units in dextrose 5% in plastic container

Heparin sodium 10,000 units in sodium chloride 0.45%

Heparin sodium 10,000 units in sodium chloride 0.9%

Heparin sodium 12,500 units in dextrose 5%

Heparin sodium 12,500 units in dextrose 5% in plastic container

Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container

Heparin sodium 12,500 units in sodium chloride 0.9%

Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container

Heparin sodium 2,000 units in dextrose 5% in plastic container

Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container

Heparin sodium 20,000 units and dextrose 5% in plastic container

Heparin sodium 20,000 units in dextrose 5% in plastic container

Heparin sodium 25,000 units and dextrose 5% in plastic container

Heparin sodium 25,000 units in dextrose 5%

Heparin sodium 25,000 units in dextrose 5% in plastic container

Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container

Heparin sodium 25,000 units in sodium chloride 0.9%

Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container

Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container

Heparin sodium 5,000 units in dextrose 5% in plastic container

Heparin sodium 5,000 units in sodium chloride 0.45%

Heparin sodium 5,000 units in sodium chloride 0.9%

Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container

Heparin sodium in plastic container

Heparin sodium preservative Free

Heparin sodium salt

Heparin sulfate

Heparin sulphate

Heparin, sodium salt

heparina

Heparina

Heparina [INN-Spanish]

Heparinate

Heparine

Heparine [INN-French]

Heparinic acid

Heparinsodiumsalt

Heparinum

Heparinum [INN-Latin]

Heparinum natricum

Hepathrom

Hepflush-10

Hep-Lock

Hep-Lock U/P

HSDB 3094

Innohep

Inno-Hep

Isocinnamic acid

Kabi 2165

KB 101

Leparan

LHN 1

Lioton 1000

Lipo-hepin

Lipo-Hepin

Liquaemin

Liquaemin Lock Flush

Liquaemin Sodium

Liquaemin sodium preservative free

Liquemin

Logiparin

Low molecular weight heparin sodium

Minolteparin sodium

MolPort-003-760-257

Multiparin

Nadroparin

Nadroparine

Novoheparin

NSC174025

Octaparin

OP 386

OP 622

Pabyrin

Panheprin

Parnaparin

Parnaparin sodium

Parvoparin

Pularin

Reviparin

Reviparin sodium

Ro 11

Sandoparin

Sodium acid heparin

Sodium heparin

Sodium heparinate

Subeparin

Sublingula

Thromboliquine

Tinzaparin

Tinzaparin sodium

Triofiban

Unfractionated heparin

UNII-12M44VTJ7B

UNII-3S182ET3UA

UNII-E47C0NF7LV

UNII-T2410KM04A

UNII-ZZ45AB24CA

Vetren

Vitrum AB

WY 90493RD

Calcium, Dietary

Phase 2

Anticoagulants

Phase 2

calcium heparin

Phase 2

Fibrinolytic Agents

Phase 2

Liver Extracts

Not Applicable

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	HEROIC (Heparin Requirement in Counterpulsation)	Terminated	NCT00445211	Phase 2	Heparin
2	Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism	Unknown status	NCT02261584	Not Applicable

Search NIH Clinical Center for Splenic Infarction

Cochrane evidence based reviews: splenic infarction

Sources

Genetic Tests for Splenic Infarction

Sources

Anatomical Context for Splenic Infarction

MalaCards organs/tissues related to Splenic Infarction:

⁴¹

Spleen, Liver, Myeloid, B Cells, Pancreas

Sources

Publications for Splenic Infarction

Articles related to Splenic Infarction:

(show top 50) (show all 306)

#	Title	Authors	Year
1	Acute Gastritis and Splenic Infarction Caused by Epstein-Barr Virus. ( 29713613 )	Jeong J.E....Park S.K.	2018
2	A case of complete splenic infarction after laparoscopic spleen-preserving distal pancreatectomy. ( 29636057 )	Kimura K....Ohira M.	2018
3	A Case of Scrub Typhus complicated with a Splenic Infarction. ( 29637756 )		2018
4	Splenic infarction due to cytomegalovirus infection in an immunocompetent patient. ( 30502300 )	Redondo A...Arteaga M	2018
5	The comorbidity of acute ischemic stroke and splenic infarction resulting from essential thrombocythemia. ( 29984396 )	Yuan J...Hu W	2018
6	Splenic artery pseudoaneurysm with splenic infarction induced by a benign gastric ulcer: A case report. ( 30024561 )	Cho SB...Lee S	2018
7	Massive Splenic Infarction in a Child With Sickle Cell Disease on Chronic Transfusion Therapy. ( 30499910 )	Pereda MA...Miller ST	2018
8	Splenic Infarction: An Under-recognized Complication of Infectious Mononucleosis? ( 29577060 )	Li Y...Abraham GM	2018
9	College Football: Conditioning Them to Death; Splenic Infarction: Keeping it in the Family. ( 30204628 )	Eichner ER	2018
10	Unusual Complications From Babesia Infection: Splenic Infarction and Splenic Rupture in Two Separate Patients. ( 30253953 )	Blackwood B...Binder W	2018
11	Spontaneous Celiac Artery Dissection Presenting With Splenic Infarction: A Case Report. ( 30344811 )	Abugroun A...Khalaf H	2018
12	Renal and Splenic Infarction in a Patient with Familial Hypercholesterolemia and Previous Cerebral Infarction. ( 30531677 )	Barzouhi AE...van Nieuwkoop C	2018
13	Long-term follow up of a massive, conservatively treated, splenic infarction in a young adolescent. ( 29044906 )	D'Angelo G....Impellizzeri P.	2017
14	Ischemic Necrosis of the Gastric Remnant without Splenic Infarction Following Subtotal Gastrectomy. ( 28835094 )	Park H.H....Sul J.Y.	2017
15	Acute Pancreatitis with Splenic Infarction as Early Postoperative Complication following Laparoscopic Sleeve Gastrectomy. ( 28487807 )	Kalabin A....Ahmed L.	2017
16	Splenic Infarction as a Delayed Febrile Complication Following Radical Gastrectomy for Gastric Cancer Patients: Computed Tomography-Based Analysis. ( 29270657 )	Jung Y.J....Park C.H.	2017
17	Splenic infarction due a common infection. ( 29078991 )	GarcA-a-VA!zquez J....Portillo MA!rquez M.	2017
18	A case of cytomegalovirus infection with splenic infarction and an esophageal ulcer in an immunocompetent adult. ( 28679983 )	Shimizu Y....Unoura M.	2017
19	Image Diagnosis: Splenic Infarction Associated with Oral Contraceptive Pills in a Healthy Young Woman. ( 28488992 )	Abdallah A.O....Motwani P.	2017
20	Splenic Infarction as Starting Symptom in Minimal Change Nephropathy. ( 28229998 )	Li Q.Y....Chen Q.K.	2017
21	Streptococcus agalactiae infective endocarditis complicated by multiple mycotic hepatic aneurysms and massive splenic infarction: a case report. ( 29284415 )		2017
22	Transient antiphospholipid syndrome and splenic infarction in a patient with parvovirus B19 acute infection. ( 28602215 )		2017
23	AN UNUSUAL CAUSE OF ACUTE ABDOMEN: SPLENIC INFARCTION. ( 29340557 )		2017
24	Splenic Infarction in Two Members of the Family with Sickle Cell Trait: A Case Report of Rare Complication. ( 29308370 )		2017
25	Splenic Infarction and Rupture Due to Melioidosis. ( 29208262 )		2017
26	Splenic infarction associated with acute infectious mononucleosis. ( 28480876 )		2017
27	Pulmonary arteriovenous malformations complicated by splenic infarction and abscess. ( 28736615 )	Naito J...Tatsumi K	2017
28	Left superior pulmonary venous thrombosis complicated with splenic infarction after video-assisted thoracoscopic left upper lobectomy. ( 30279783 )	Harada R...Kataoka M	2017
29	Sequential Insults: Acute Lyme Disease with Splenic Infarction. ( 26688425 )	Dick J.F.	2016
30	A Case of Isolated Celiac Artery Dissection Accompanied by Splenic Infarction Detected by Ultrasonography in the Emergency Department. ( 27148460 )	Emori K....Soneda J.	2016
31	Splenic Infarction in Acute Infectious Mononucleosis. ( 26602427 )	Naviglio S....Ventura A.	2016
32	Massive splenic infarction and splenic venous thrombosis observed in a patient with acute splenic syndrome of sickle cell traits on contrast-enhanced thin-slice computed tomography. ( 27251735 )	Hayashi T.Y....Hagiwara A.	2016
33	Splenic infarction as a pitfall on labeled red blood cell imaging. ( 26917904 )	Aktas G.E....Sarikaya A.	2016
34	Splenic infarction associated with acute infectious mononucleosis due to Epstein-Barr virus infection. ( 27357912 )	Heo D.H....Hwang J.H.	2016
35	Dangerous proximity: splenic infarction after abdominal abscess. ( 25448176 )	Schattner A....Adi M.	2015
36	A Diagnostic Pitfall: Salmonella Splenic Infarction in Hereditary Spherocytosis. ( 26272774 )	Sridhar S....Woo P.C.	2015
37	The unexpected finding of a splenic infarction in a patient with infectious mononucleosis due to Epstein-Barr virus. ( 26607191 )	Machado C....Monjardino L.	2015
38	An adolescent with hereditary spherocytosis who presented with splenic infarction. ( 26139647 )	Jones L....Linney M.	2015
39	Mycosis fungoides associated with splenic infarction and muscle involvement. ( 25994394 )	Watanabe M....Shimizu H.	2015
40	Splenic infarction after reversal of warfarin using Prothrombinex-VF in a patient with a mechanical aortic valve. ( 26224191 )	Sharma V....Anand D.	2015
41	Brachial artery mycotic aneurysm and splenic infarction associated with infective endocarditis. ( 26186921 )	Lin C.H....Hu S.Y.	2015
42	Evaluation with contrast ultrasound of the prevalence of splenic infarction in left-sided infective endocarditis. ( 26261464 )	Menozzi G....Garlassi E.	2015
43	Splenic infarction associated with sickle cell trait at low altitude. ( 26133225 )	Seegars M.B....Brett A.S.	2015
44	Acute Splenic Infarction at an Academic General Hospital Over 10 Years: Presentation, Etiology, and Outcome. ( 26356690 )		2015
45	Splenic infarction - A rare cause of acute abdominal pain following gastric surgery: A case series. ( 25818369 )		2015
46	Incidentally Discovered Splenic Infarction Associated with Scrub Typhus. ( 26333728 )		2015
47	Splenic infarction and G-CSF. ( 26840787 )		2015
48	Splenic Infarction in Polycythemia Vera: Can the Spleen be Saved? ( 26731841 )		2015
49	Massive splenic infarction leading to sickle cell disease. ( 25075666 )	Mengual-Ballester M....Aguayo-Albasini J.L.	2014
50	Splenic infarction in Plasmodium vivax malaria. ( 24825280 )	Taneja S....Mittal P.	2014

Sources

Genes for Splenic Infarction

Genes related to Splenic Infarction (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	HBB	Hemoglobin Subunit Beta	Protein Coding	22.45	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	APOH	Apolipoprotein H	Protein Coding	16.46	Novoseek inferred ⁵⁵	8508712 10193074 15714383 (more) 14964553 19158473
3	HORMAD1	HORMA Domain Containing 1	Protein Coding	15.26	DISEASES inferred ¹⁵
4	CPA1	Carboxypeptidase A1	Protein Coding	15.12	DISEASES inferred ¹⁵
5	PIEZO1	Piezo Type Mechanosensitive Ion Channel Component 1	Protein Coding	14.95	DISEASES inferred ¹⁵
6	SAA1	Serum Amyloid A1	Protein Coding	14.89	DISEASES inferred ¹⁵
7	STK10	Serine/Threonine Kinase 10	Protein Coding	14.77	DISEASES inferred ¹⁵

Sources

Variations for Splenic Infarction

Sources

Expression for Splenic Infarction

Search GEO for disease gene expression data for Splenic Infarction.

Sources

Pathways for Splenic Infarction

Pathways related to Splenic Infarction according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.29	HBB SAA1
2	Binding and Uptake of Ligands by Scavenger Receptors ⁶⁶ Show member pathways Scavenging by Class A Receptors ⁶⁶ Scavenging by Class B Receptors ⁶⁶ Scavenging by Class F Receptors ⁶⁶ Scavenging by Class H Receptors ⁶⁶ Scavenging of heme from plasma ⁶⁶	10.64	HBB SAA1

Sources

GO Terms for Splenic Infarction

Cellular components related to Splenic Infarction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.56	APOH HBB SAA1 STK10
2	extracellular space	GO:0005615	9.46	APOH CPA1 HBB SAA1
3	high-density lipoprotein particle	GO:0034364	8.96	APOH SAA1
4	endocytic vesicle lumen	GO:0071682	8.62	HBB SAA1

Biological processes related to Splenic Infarction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	receptor-mediated endocytosis	GO:0006898	8.62	HBB SAA1

Molecular functions related to Splenic Infarction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heparin binding	GO:0008201	8.62	APOH SAA1

Sources

Sources for Splenic Infarction

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia