MCID: SPL006
MIFTS: 37

Splenic Infarction

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Splenic Infarction

MalaCards integrated aliases for Splenic Infarction:

Name: Splenic Infarction 12 54 43 15 17 71
Infarct of the Spleen 52
Splenic Infarcts 52
Splenic Infarct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2533
MeSH 43 D013159
SNOMED-CT 67 22996003
ICD10 32 D73.5
UMLS 71 C0037998

Summaries for Splenic Infarction

MalaCards based summary : Splenic Infarction, also known as infarct of the spleen, is related to infective endocarditis and endocarditis. An important gene associated with Splenic Infarction is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Visual Cycle in Retinal Rods. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and heart.

Wikipedia : 74 Splenic infarction is a condition in which blood flow supply to the spleen is compromised, leading to... more...

Related Diseases for Splenic Infarction

Diseases related to Splenic Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 533)
# Related Disease Score Top Affiliating Genes
1 infective endocarditis 30.8 F2 CRP APOH
2 endocarditis 30.8 SERPINC1 F2 CRP APOH
3 sickle cell anemia 30.7 HBB F2 CD40LG
4 splenic artery aneurysm 30.5 SAA1 PCSK1N
5 vasculitis 30.4 SERPINA3 CRP CD40LG APOH
6 thrombophilia due to thrombin defect 30.4 SERPINC1 F3 F2 APOH
7 protein c deficiency 30.3 SERPINC1 F2 APOH
8 subacute bacterial endocarditis 30.3 CRP CD40LG
9 acute pancreatitis 30.2 SERPINA3 GPT CRP
10 erythema infectiosum 30.2 CD40LG APOH
11 neuroretinitis 30.2 CRP CD40LG
12 atrial fibrillation 30.1 SERPINC1 F3 F2 CRP
13 spinal cord infarction 30.1 SERPINC1 F2 APOH
14 hypersplenism 30.1 SERPINC1 GPT F2
15 deficiency anemia 30.0 JAK2 HP HBB CRP
16 pyoderma 30.0 F3 CRP APOH
17 polyarteritis nodosa 30.0 GPT CRP APOH
18 brucellosis 30.0 SAA1 CRP CD40LG
19 abdominal tuberculosis 29.9 F2 CRP CD40LG
20 epidemic typhus 29.9 GPT CRP CD40LG
21 splenic abscess 29.9 PCSK1N GPT F2 CRP CD40LG
22 hemoglobinuria 29.9 SERPINC1 HP F2
23 protein s deficiency 29.9 SERPINC1 F3 F2 APOH
24 intermediate coronary syndrome 29.9 SERPINC1 F3 CRP
25 paroxysmal nocturnal hemoglobinuria 29.9 SERPINC1 HP F2
26 leptospirosis 29.9 F2 CRP CD40LG
27 sarcoidosis 1 29.9 SERPINA3 CRP CD40LG
28 heparin-induced thrombocytopenia 29.9 SERPINC1 F3 CD40LG
29 mycoplasma pneumoniae pneumonia 29.9 F3 CRP CD40LG
30 toxic shock syndrome 29.9 SERPINC1 F3 CRP CD40LG
31 hemolytic anemia 29.8 HP HBB F3 CD40LG APOH
32 babesiosis 29.8 HP GPT CD40LG
33 splenic sequestration 29.7 HP HBB F3 F2 CD40LG
34 antiphospholipid syndrome 29.7 SERPINC1 F3 F2 CRP CD40LG APOH
35 scrub typhus 29.7 GPT F3 CRP CD40LG
36 thrombocytosis 29.6 SERPINC1 JAK2 F3 F2 CRP
37 intestinal obstruction 29.6 SERPINA3 GPT CRP
38 migraine with or without aura 1 29.6 F2 CRP CD40LG APOH
39 portal hypertension 29.5 JAK2 GPT F3 F2 CD40LG
40 anemia, autoimmune hemolytic 29.5 HP CD5 CD40LG
41 pharyngitis 29.5 GPT CRP CD40LG
42 thrombosis 29.5 SERPINC1 JAK2 F3 F2 CD40LG APOH
43 pulmonary hypertension 29.5 SERPINC1 F3 F2 CRP
44 cholecystitis 29.5 HP GPT F2
45 pulmonary embolism 29.4 SERPINC1 F3 F2 CRP CD40LG APOH
46 kawasaki disease 29.4 GPT CRP CD40LG
47 disseminated intravascular coagulation 29.4 SERPINC1 GPT F3 F2 CRP
48 plasmodium falciparum malaria 29.4 HP HBB CRP CD40LG
49 acute kidney failure 29.4 HP GPT F2
50 pulmonary edema 29.4 SERPINC1 HP F2 CRP

Graphical network of the top 20 diseases related to Splenic Infarction:



Diseases related to Splenic Infarction

Symptoms & Phenotypes for Splenic Infarction

Drugs & Therapeutics for Splenic Infarction

Drugs for Splenic Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis Withdrawn NCT01932554 Phase 2 Abciximab;Placebo;Ibuprofen;Parenteral narcotic
2 Comparative Study of Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584

Search NIH Clinical Center for Splenic Infarction

Cochrane evidence based reviews: splenic infarction

Genetic Tests for Splenic Infarction

Anatomical Context for Splenic Infarction

MalaCards organs/tissues related to Splenic Infarction:

40
Spleen, Liver, Heart, B Cells, Lung, Pancreas, Bone

Publications for Splenic Infarction

Articles related to Splenic Infarction:

(show top 50) (show all 955)
# Title Authors PMID Year
1
[A case of acute pancreatitis and splenic infarction associated with antiphospholipid syndrome]. 54 61
19158473 2009
2
Splenic infarction in a pregnant woman with systemic lupus erythematosus. 54 61
15714383 2005
3
Splenic infarction associated with anti-cardiolipin antibody: a report of two cases. 54 61
14964553 2004
4
[Splenic infarction in a patient with anticardiolipin antibodies and leptospirosis]. 54 61
10193074 1999
5
Splenic infarction associated with anticardiolipin antibodies in a patient with acquired immunodeficiency syndrome. 54 61
8508712 1993
6
Splenic Infarction in a Narcoleptic Patient Treated With Methylphenidate, Venlafaxine, and Pitolisant. 61
31502855 2020
7
Laparoscopic management of gastric remnant ischemia after laparoscopic distal gastrectomy with Billroth-I anastomosis-A case report. 61
31884262 2020
8
Laparoscopic ligation of splenic vessels for the treatment of hereditary spherocytosis in children. 61
31982941 2020
9
Hyperviscosity-related splenic infarction, gastrointestinal ischaemia-reperfusion injury and transient dysarthria in a patient with distributive shock due to idiopathic systemic capillary leak syndrome (Clarkson's syndrome). 61
31980475 2020
10
Ovarian Cancer Presenting as Cryptogenic Stroke from Patent Foramen Ovale. 61
31324738 2019
11
Descending aortic replacement for intimal angiosarcoma. 61
31263892 2019
12
Splenic infarct with scrub typhus: a rare presentation. 61
31789114 2019
13
Massive Splenic Infarction and Autosplencetomy: First Presentation of Homozygous Sickle Cell Disease in a Toddler. 61
31842178 2019
14
Splenic infarction complicated with immune reconstitution inflammatory syndrome due to disseminated Mycobacterium genavense infection in a patient infected with human immunodeficiency virus. 61
31227383 2019
15
Association Between Troponin Levels and Visceral Infarction in Patients with Acute Ischemic Stroke. 61
31668582 2019
16
Splenic findings in patients with acute babesiosis. 61
31832741 2019
17
Response to letter of Dr Jolobe entitled Paradoxical embolism as a cause of renal and/or splenic infarction Manuscripts submitted to QJM (ref 123456789). 61
31681947 2019
18
Paradoxical embolism as a cause of renal and/or splenic infarction. 61
31681946 2019
19
Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial. 61
31758329 2019
20
Unusual solution to abdominal pain with contrast enhanced ultrasound. 61
31690686 2019
21
Association between MTHFR 677C>T polymorphism and vascular complications in sickle cell disease: A meta-analysis. 61
30686687 2019
22
Preservation or Ligation of Splenic Vessels During Spleen-Preserving Distal Pancreatectomy: A Meta-Analysis. 61
29641270 2019
23
Splenic infarction associated with transient anti-prothrombin antibodies is a rare manifestation of acute Mycoplasma pneumoniae infection. 61
31740285 2019
24
Mesenteric Ischemia due to Thrombosis Involving the Aorta, Celiac Artery, and Superior Mesenteric Artery in a Young Female with Protein C Deficiency. 61
31890360 2019
25
Splenic Infarction: A Dark Side of the Nephrotic Syndrome. 61
31715160 2019
26
Cytomegalovirus-Associated Splenic Infarction. 61
31622579 2019
27
Splenic Infarction in Plasmodium vivax Infection in South Korea. 61
31436158 2019
28
Coeliac trunk dissection causing splenic infarction: a comprehensive review. 61
31615776 2019
29
A Rare Cause of Gastrointestinal Bleeding in a 65-Year-Old Man with History of Polycythemia Vera. 61
31824626 2019
30
Multiple Splenic Infarcts Complicating Plasmodium vivax Malaria. 61
31593054 2019
31
Unusual Presentation of Aspergillus Pericarditis: A Case Report. 61
31543739 2019
32
Splenic Infarct on Exposure to Extreme High Altitude in Individuals with Sickle Trait: A Single-Center Experience. 61
31407926 2019
33
"Bright Band Sign" A Grayscale Ultrasound Finding in Hepatic Infarction. 61
30666665 2019
34
Splenic infarction in babesiosis: A rare presentation. 61
31428398 2019
35
Uncommon presentations in ANCA vasculitis: clinical characteristics and outcomes. 61
31037456 2019
36
A rare case of non-traumatic intrasplenic pseudoaneurysms in a patient with acute T-cell lymphoblastic leukemia. 61
31372947 2019
37
Partial Splenic Artery Embolization in 35 Cancer Patients: Results of a Single Institution Retrospective Study. 61
31471193 2019
38
Infective endocarditis due to Granulicatella elegans presenting with musculoskeletal symptoms. 61
31466970 2019
39
[Massive splenic infarct in a pediatric patient without predisposing factors]. 61
31339281 2019
40
"Wandering spleen" as a rare cause of recurrent abdominal pain: a systematic review. 61
30019879 2019
41
Splenic Infarction after Warfarin Overdose Treatment: Is It a Coincidence or Complication? 61
31009721 2019
42
Robotic spleen-preserving splenic hilar lymph node dissection during total gastrectomy for gastric cancer. 61
30945060 2019
43
Acute splenic infarction presenting as an unusual manifestation of essential thrombocythaemia with normal platelet count. 61
31272993 2019
44
Splenic infarction due to cytomegalovirus infection in an immunocompetent patient. 61
30502300 2019
45
Video-robotic aneurismectomy for splenic artery aneurysm: case report and literature review. 61
31250696 2019
46
Splinter haemorrhages, splenic infarcts, and pulmonary embolism in granulomatosis with polyangiitis. 61
30426847 2019
47
Splenic Marginal Zone B-Cell Lymphoma With Splenic Infarction in a Patient With Cold Agglutinin Disease. 61
30888998 2019
48
Splenic infarction from vascular torsion in a child with normal splenic anatomy. 61
31092484 2019
49
Dual-interventional therapy for multiple splenic artery aneurysms in a patient with portal hypertension: A case report. 61
31083153 2019
50
Serum Troponin Level in Acute Ischemic Stroke Identifies Patients with Visceral Infarcts. 61
30665837 2019

Variations for Splenic Infarction

Expression for Splenic Infarction

Search GEO for disease gene expression data for Splenic Infarction.

Pathways for Splenic Infarction

GO Terms for Splenic Infarction

Cellular components related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 SERPINC1 SERPINA3 SAA1 HP HBB GPT
2 extracellular region GO:0005576 9.73 SERPINC1 SERPINA3 SAA1 PCSK1N HP HBB
3 collagen-containing extracellular matrix GO:0062023 9.72 SERPINC1 SERPINA3 F3 F2 APOH
4 blood microparticle GO:0072562 9.55 SERPINC1 SERPINA3 HP HBB F2
5 endocytic vesicle lumen GO:0071682 9.43 SAA1 HP HBB
6 haptoglobin-hemoglobin complex GO:0031838 9.4 HP HBB
7 extracellular space GO:0005615 9.4 SERPINC1 SERPINA3 SAA1 PCSK1N HP HBB

Biological processes related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.58 SAA1 F2 CD40LG
2 blood coagulation GO:0007596 9.55 SERPINC1 JAK2 HBB F3 F2
3 blood coagulation, intrinsic pathway GO:0007597 9.43 F2 APOH
4 hemostasis GO:0007599 9.43 SERPINC1 F3 F2
5 positive regulation of blood coagulation GO:0030194 9.37 F2 APOH
6 negative regulation of fibrinolysis GO:0051918 9.32 F2 APOH
7 regulation of blood coagulation GO:0030193 9.13 SERPINC1 F2 APOH
8 acute-phase response GO:0006953 9.02 SERPINA3 SAA1 HP F2 CRP

Molecular functions related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase inhibitor activity GO:0004867 9.33 SERPINC1 SERPINA3 PCSK1N
2 hemoglobin binding GO:0030492 8.96 HP HBB
3 heparin binding GO:0008201 8.92 SERPINC1 SAA1 F2 APOH

Sources for Splenic Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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