MCID: SPL006
MIFTS: 35

Splenic Infarction

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Splenic Infarction

MalaCards integrated aliases for Splenic Infarction:

Name: Splenic Infarction 12 55 44 15 17 72
Infarct of the Spleen 53
Splenic Infarcts 53
Splenic Infarct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2533
MeSH 44 D013159
SNOMED-CT 68 22996003
ICD10 33 D73.5
UMLS 72 C0037998

Summaries for Splenic Infarction

MalaCards based summary : Splenic Infarction, also known as infarct of the spleen, is related to endocarditis and infective endocarditis. An important gene associated with Splenic Infarction is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and pancreas.

Wikipedia : 75 Splenic infarction is a condition in which blood flow supply to the spleen is compromised, leading to... more...

Related Diseases for Splenic Infarction

Diseases related to Splenic Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 320)
# Related Disease Score Top Affiliating Genes
1 endocarditis 30.7 F2 APOH
2 infective endocarditis 30.3 F2 APOH
3 sickle cell anemia 29.9 HBB F2
4 thrombotic thrombocytopenic purpura 29.9 F3 APOH
5 portal vein thrombosis 29.8 F2 APOH
6 spinal cord infarction 29.7 F2 APOH
7 antiphospholipid syndrome 29.7 F3 F2 APOH
8 thrombophlebitis 29.7 F2 APOH
9 thrombosis 29.7 F3 F2 APOH
10 ischemic colitis 29.6 F2 APOH
11 thrombophilia due to thrombin defect 29.6 F3 F2 APOH
12 disseminated intravascular coagulation 29.6 F3 F2
13 thrombocytosis 29.5 F3 F2
14 pulmonary embolism 29.5 F3 F2 APOH
15 vascular disease 29.3 F3 F2 APOH
16 thrombophilia 29.3 F3 F2 APOH
17 protein s deficiency 29.2 F3 F2 APOH
18 purpura 29.2 F3 F2 APOH
19 stroke, ischemic 29.1 F3 F2 APOH
20 hepatic infarction 29.0 F3 F2 APOH
21 budd-chiari syndrome 29.0 F3 F2 APOH
22 patent foramen ovale 28.8 F2 APOH
23 hemoglobin se disease 11.7
24 sickle cell - hemoglobin d disease 11.4
25 splenomegaly 10.5
26 pfeiffer syndrome 10.4
27 splenic abscess 10.4
28 malaria 10.3
29 catastrophic antiphospholipid syndrome 10.3 F3 APOH
30 pancreatitis 10.3
31 intracranial thrombosis 10.3 F3 APOH
32 hemolytic anemia 10.2
33 vasculitis 10.2
34 factor xii deficiency 10.2 F3 APOH
35 deficiency anemia 10.2
36 portal hypertension 10.2
37 hereditary spherocytosis 10.2
38 liver cirrhosis 10.2
39 sickle cell disease 10.2
40 acute pancreatitis 10.2
41 peritonitis 10.2
42 polycythemia 10.2
43 temporal arteritis 10.2 SERPINA3 APOH
44 polycythemia vera 10.2
45 aneurysm 10.2
46 varicose veins 10.1
47 atrial fibrillation 10.1
48 splenic sequestration 10.1
49 thrombocytopenia 10.1
50 b-cell lymphoma 10.1

Graphical network of the top 20 diseases related to Splenic Infarction:



Diseases related to Splenic Infarction

Symptoms & Phenotypes for Splenic Infarction

Drugs & Therapeutics for Splenic Infarction

Drugs for Splenic Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis Withdrawn NCT01932554 Phase 2 Abciximab;Placebo;Ibuprofen;Parenteral narcotic
2 Comparative Study of Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584

Search NIH Clinical Center for Splenic Infarction

Cochrane evidence based reviews: splenic infarction

Genetic Tests for Splenic Infarction

Anatomical Context for Splenic Infarction

MalaCards organs/tissues related to Splenic Infarction:

41
Spleen, Liver, Pancreas, Heart, B Cells, Lung, Bone

Publications for Splenic Infarction

Articles related to Splenic Infarction:

(show top 50) (show all 931)
# Title Authors PMID Year
1
[A case of acute pancreatitis and splenic infarction associated with antiphospholipid syndrome]. 9 38
19158473 2009
2
Splenic infarction in a pregnant woman with systemic lupus erythematosus. 9 38
15714383 2005
3
Splenic infarction associated with anti-cardiolipin antibody: a report of two cases. 9 38
14964553 2004
4
[Splenic infarction in a patient with anticardiolipin antibodies and leptospirosis]. 9 38
10193074 1999
5
Splenic infarction associated with anticardiolipin antibodies in a patient with acquired immunodeficiency syndrome. 9 38
8508712 1993
6
"Bright Band Sign" A Grayscale Ultrasound Finding in Hepatic Infarction. 38
30666665 2019
7
Splenic Infarct on Exposure to Extreme High Altitude in Individuals with Sickle Trait: A Single-Center Experience. 38
31407926 2019
8
Splenic infarction in babesiosis: A rare presentation. 38
31428398 2019
9
Splenic Infarction in Plasmodium vivax Infection in South Korea. 38
31436158 2019
10
A rare case of non-traumatic intrasplenic pseudoaneurysms in a patient with acute T-cell lymphoblastic leukemia. 38
31372947 2019
11
Uncommon presentations in ANCA vasculitis: clinical characteristics and outcomes. 38
31037456 2019
12
Splenic Infarction after Warfarin Overdose Treatment: Is It a Coincidence or Complication? 38
31009721 2019
13
[Massive splenic infarct in a pediatric patient without predisposing factors]. 38
31339281 2019
14
"Wandering spleen" as a rare cause of recurrent abdominal pain: a systematic review. 38
30019879 2019
15
Acute splenic infarction presenting as an unusual manifestation of essential thrombocythaemia with normal platelet count. 38
31272993 2019
16
Ovarian Cancer Presenting as Cryptogenic Stroke from Patent Foramen Ovale. 38
31324738 2019
17
Robotic spleen-preserving splenic hilar lymph node dissection during total gastrectomy for gastric cancer. 38
30945060 2019
18
Descending aortic replacement for intimal angiosarcoma. 38
31263892 2019
19
Splinter haemorrhages, splenic infarcts, and pulmonary embolism in granulomatosis with polyangiitis. 38
30426847 2019
20
Video-robotic aneurismectomy for splenic artery aneurysm: case report and literature review. 38
31250696 2019
21
Splenic infarction due to cytomegalovirus infection in an immunocompetent patient. 38
30502300 2019
22
Splenic infarction complicated with immune reconstitution inflammatory syndrome due to disseminated Mycobacterium genavense infection in a patient infected with human immunodeficiency virus. 38
31227383 2019
23
Serum Troponin Level in Acute Ischemic Stroke Identifies Patients with Visceral Infarcts. 38
30665837 2019
24
Splenic infarction from vascular torsion in a child with normal splenic anatomy. 38
31092484 2019
25
Dual-interventional therapy for multiple splenic artery aneurysms in a patient with portal hypertension: A case report. 38
31083153 2019
26
Splenic Marginal Zone B-Cell Lymphoma With Splenic Infarction in a Patient With Cold Agglutinin Disease. 38
30888998 2019
27
Massive Splenic Infarction in a Child With Sickle Cell Disease on Chronic Transfusion Therapy. 38
30499910 2019
28
Clinical Comparison of Spleen-Preserving Distal Pancreatectomy With or Without Splenic Vessel Preservation: A Systematic Review and Meta-Analysis. 38
30312137 2019
29
Partial splenic embolization with Glubran®2/Lipiodol® mixture for oncological patients with hypersplenism-related thrombocytopenia requiring systemic chemotherapy. 38
31032188 2019
30
Splenic necrosis requiring ultrasound-guided drainage following meningococcal septicaemia. 38
30949357 2019
31
Laparoscopic splenectomy for polysplenia with splenic torsion: a case report. 38
30778694 2019
32
Splenic infarction induced by epstein-barr virus infection in a patient with sickle cell trait. 38
30746887 2019
33
Splenic Artery Aneurysms, A Rare Complication of Type 1 Gaucher Disease: Report of Five Cases. 38
30744043 2019
34
Epstein Barr Virus-induced Antiphospholipid Antibodies Resulting in Splenic Infarct: A Case Report. 38
31037233 2019
35
True learning curve of laparoscopic spleen-preserving distal pancreatectomy with splenic vessel preservation. 38
29934868 2019
36
Pulmonary embolism with migrating thrombus through patent foramen ovale: A case for a mixed pharmacological and percutaneous management. 38
30693053 2019
37
Association between MTHFR 677C>T polymorphism and vascular complications in sickle cell disease: A meta-analysis. 38
30686687 2019
38
[Essential thrombocythemia accompanied by adrenal infarction]. 38
30842376 2019
39
Splenic infarction as a rare presentation of severe babesiosis. 38
30740305 2019
40
Warshaw Technique in Laparoscopic Spleen-Preserving Distal Pancreatectomy: Surgical Strategy and Late Outcomes of Splenic Preservation. 38
31317027 2019
41
Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy Regimen. 38
30906610 2019
42
Unusual Case of Life-Threatening Gastro Intestinal Bleed from a Splenic Artery Pseudoaneurysm: Case Report and Review of Literature. 38
30881708 2019
43
Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea. 38
30630283 2018
44
Canis Caveat (Beware of the Dog) - Septic Shock Due To Capnocytophaga Canimorsus Contracted From A Dog Bite 38
30560637 2018
45
Splenic Infarction as Only Manifestation of Antiphospholipid Syndrome in a Patient With Rheumatoid Arthritis. 38
30601167 2018
46
Renal and Splenic Infarction in a Patient with Familial Hypercholesterolemia and Previous Cerebral Infarction. 38
30531677 2018
47
Splenic Artery Aneurysm Treated With Endovascular Stent Grafting: A Case Report and Review of Literature. 38
29940816 2018
48
Splenic embolization for a giant splenic hemangioma in a child: a case report. 38
30419881 2018
49
Splenic infarction due a common infection. 38
29078991 2018
50
Unusual Complications From Babesia Infection: Splenic Infarction and Splenic Rupture in Two Separate Patients. 38
30253953 2018

Variations for Splenic Infarction

Expression for Splenic Infarction

Search GEO for disease gene expression data for Splenic Infarction.

Pathways for Splenic Infarction

Pathways related to Splenic Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 SERPINA3 HBB F3 F2 APOH
2
Show member pathways
11.26 SERPINA3 SAA1 HBB F2

GO Terms for Splenic Infarction

Cellular components related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 SERPINA3 SAA1 HBB F2 APOH
2 collagen-containing extracellular matrix GO:0062023 9.54 SERPINA3 F3 APOH
3 extracellular region GO:0005576 9.43 SERPINA3 SAA1 HBB F3 F2 APOH
4 blood microparticle GO:0072562 9.33 SERPINA3 HBB F2
5 high-density lipoprotein particle GO:0034364 9.32 SAA1 APOH
6 endocytic vesicle lumen GO:0071682 9.26 SAA1 HBB
7 extracellular space GO:0005615 9.1 SERPINA3 SAA1 HBB F3 F2 APOH

Biological processes related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.54 HBB F3 F2
2 hemostasis GO:0007599 9.4 F3 F2
3 blood coagulation, intrinsic pathway GO:0007597 9.32 F2 APOH
4 regulation of blood coagulation GO:0030193 9.26 F2 APOH
5 positive regulation of blood coagulation GO:0030194 9.16 F2 APOH
6 negative regulation of fibrinolysis GO:0051918 8.96 F2 APOH
7 acute-phase response GO:0006953 8.8 SERPINA3 SAA1 F2

Molecular functions related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 SAA1 F2 APOH

Sources for Splenic Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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