MCID: SPL006
MIFTS: 34

Splenic Infarction

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Splenic Infarction

MalaCards integrated aliases for Splenic Infarction:

Name: Splenic Infarction 12 55 44 15 73
Infarct of the Spleen 53
Splenic Infarcts 53
Splenic Infarct 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2533
ICD10 33 D73.5
MeSH 44 D013159
SNOMED-CT 68 22996003
UMLS 73 C0037998

Summaries for Splenic Infarction

MalaCards based summary : Splenic Infarction, also known as infarct of the spleen, is related to hemolytic anemia and thrombosis. An important gene associated with Splenic Infarction is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Selenium Micronutrient Network and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Heparin and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and myeloid.

Wikipedia : 76 Splenic infarction is a condition in which oxygen supply to the spleen is interrupted, leading to... more...

Related Diseases for Splenic Infarction

Diseases related to Splenic Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 hemolytic anemia 29.7 HBB PIEZO1
2 thrombosis 10.3
3 endocarditis 10.3
4 malaria 10.2
5 pancreatitis 10.2
6 infective endocarditis 10.1
7 hereditary spherocytosis 10.1
8 acute pancreatitis 10.1
9 viral infectious disease 10.1
10 thrombophilia due to thrombin defect 10.0
11 anemia, autoimmune hemolytic 10.0
12 polycythemia vera 10.0
13 lymphoma 10.0
14 peritonitis 10.0
15 polycythemia 10.0
16 sickle cell disease 10.0
17 systemic lupus erythematosus 9.9
18 sickle cell anemia 9.9
19 polyarteritis nodosa, childhood-onset 9.9
20 leukemia 9.9
21 thrombocytopenia 9.9
22 splenic sequestration 9.9
23 plasmodium vivax malaria 9.9
24 scrub typhus 9.9
25 hemoglobin c disease 9.9
26 antiphospholipid syndrome 9.9
27 protein c deficiency 9.9
28 lupus erythematosus 9.9
29 pulmonary embolism 9.9
30 polyarteritis nodosa 9.9
31 splenomegaly 9.9
32 cytomegalovirus infection 9.9
33 congenital hemolytic anemia 9.9 HBB PIEZO1
34 pfeiffer syndrome 9.9
35 pancreatic cancer 9.9
36 granulomatosis with polyangiitis 9.9
37 gastric cancer 9.9
38 b-cell lymphomas 9.9
39 paroxysmal nocturnal hemoglobinuria 9.9
40 thalassemia 9.9
41 lymphocytic leukemia 9.9
42 portal hypertension 9.9
43 gastric ulcer 9.9
44 brucellosis 9.9
45 q fever 9.9
46 splenic artery aneurysm 9.9
47 toxic shock syndrome 9.9
48 splenic abscess 9.9
49 subacute bacterial endocarditis 9.9
50 hemoglobinuria 9.9

Graphical network of the top 20 diseases related to Splenic Infarction:



Diseases related to Splenic Infarction

Symptoms & Phenotypes for Splenic Infarction

Drugs & Therapeutics for Splenic Infarction

Drugs for Splenic Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
2 Calcium, Dietary Phase 2
3 Anticoagulants Phase 2
4 calcium heparin Phase 2
5 Fibrinolytic Agents Phase 2
6 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HEROIC (Heparin Requirement in Counterpulsation) Terminated NCT00445211 Phase 2 Heparin
2 Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584 Not Applicable

Search NIH Clinical Center for Splenic Infarction

Cochrane evidence based reviews: splenic infarction

Genetic Tests for Splenic Infarction

Anatomical Context for Splenic Infarction

MalaCards organs/tissues related to Splenic Infarction:

41
Spleen, Liver, Myeloid, B Cells, Pancreas

Publications for Splenic Infarction

Articles related to Splenic Infarction:

(show top 50) (show all 306)
# Title Authors Year
1
Acute Gastritis and Splenic Infarction Caused by Epstein-Barr Virus. ( 29713613 )
2018
2
A case of complete splenic infarction after laparoscopic spleen-preserving distal pancreatectomy. ( 29636057 )
2018
3
A Case of Scrub Typhus complicated with a Splenic Infarction. ( 29637756 )
2018
4
Splenic infarction due to cytomegalovirus infection in an immunocompetent patient. ( 30502300 )
2018
5
The comorbidity of acute ischemic stroke and splenic infarction resulting from essential thrombocythemia. ( 29984396 )
2018
6
Splenic artery pseudoaneurysm with splenic infarction induced by a benign gastric ulcer: A case report. ( 30024561 )
2018
7
Massive Splenic Infarction in a Child With Sickle Cell Disease on Chronic Transfusion Therapy. ( 30499910 )
2018
8
Splenic Infarction: An Under-recognized Complication of Infectious Mononucleosis? ( 29577060 )
2018
9
College Football: Conditioning Them to Death; Splenic Infarction: Keeping it in the Family. ( 30204628 )
2018
10
Unusual Complications From Babesia Infection: Splenic Infarction and Splenic Rupture in Two Separate Patients. ( 30253953 )
2018
11
Spontaneous Celiac Artery Dissection Presenting With Splenic Infarction: A Case Report. ( 30344811 )
2018
12
Renal and Splenic Infarction in a Patient with Familial Hypercholesterolemia and Previous Cerebral Infarction. ( 30531677 )
2018
13
Long-term follow up of a massive, conservatively treated, splenic infarction in a young adolescent. ( 29044906 )
2017
14
Ischemic Necrosis of the Gastric Remnant without Splenic Infarction Following Subtotal Gastrectomy. ( 28835094 )
2017
15
Acute Pancreatitis with Splenic Infarction as Early Postoperative Complication following Laparoscopic Sleeve Gastrectomy. ( 28487807 )
2017
16
Splenic Infarction as a Delayed Febrile Complication Following Radical Gastrectomy for Gastric Cancer Patients: Computed Tomography-Based Analysis. ( 29270657 )
2017
17
Splenic infarction due a common infection. ( 29078991 )
2017
18
A case of cytomegalovirus infection with splenic infarction and an esophageal ulcer in an immunocompetent adult. ( 28679983 )
2017
19
Image Diagnosis: Splenic Infarction Associated with Oral Contraceptive Pills in a Healthy Young Woman. ( 28488992 )
2017
20
Splenic Infarction as Starting Symptom in Minimal Change Nephropathy. ( 28229998 )
2017
21
Streptococcus agalactiae infective endocarditis complicated by multiple mycotic hepatic aneurysms and massive splenic infarction: a case report. ( 29284415 )
2017
22
Transient antiphospholipid syndrome and splenic infarction in a patient with parvovirus B19 acute infection. ( 28602215 )
2017
23
AN UNUSUAL CAUSE OF ACUTE ABDOMEN: SPLENIC INFARCTION. ( 29340557 )
2017
24
Splenic Infarction in Two Members of the Family with Sickle Cell Trait: A Case Report of Rare Complication. ( 29308370 )
2017
25
Splenic Infarction and Rupture Due to Melioidosis. ( 29208262 )
2017
26
Splenic infarction associated with acute infectious mononucleosis. ( 28480876 )
2017
27
Pulmonary arteriovenous malformations complicated by splenic infarction and abscess. ( 28736615 )
2017
28
Left superior pulmonary venous thrombosis complicated with splenic infarction after video-assisted thoracoscopic left upper lobectomy. ( 30279783 )
2017
29
Sequential Insults: Acute Lyme Disease with Splenic Infarction. ( 26688425 )
2016
30
A Case of Isolated Celiac Artery Dissection Accompanied by Splenic Infarction Detected by Ultrasonography in the Emergency Department. ( 27148460 )
2016
31
Splenic Infarction in Acute Infectious Mononucleosis. ( 26602427 )
2016
32
Massive splenic infarction and splenic venous thrombosis observed in a patient with acute splenic syndrome of sickle cell traits on contrast-enhanced thin-slice computed tomography. ( 27251735 )
2016
33
Splenic infarction as a pitfall on labeled red blood cell imaging. ( 26917904 )
2016
34
Splenic infarction associated with acute infectious mononucleosis due to Epstein-Barr virus infection. ( 27357912 )
2016
35
Dangerous proximity: splenic infarction after abdominal abscess. ( 25448176 )
2015
36
A Diagnostic Pitfall: Salmonella Splenic Infarction in Hereditary Spherocytosis. ( 26272774 )
2015
37
The unexpected finding of a splenic infarction in a patient with infectious mononucleosis due to Epstein-Barr virus. ( 26607191 )
2015
38
An adolescent with hereditary spherocytosis who presented with splenic infarction. ( 26139647 )
2015
39
Mycosis fungoides associated with splenic infarction and muscle involvement. ( 25994394 )
2015
40
Splenic infarction after reversal of warfarin using Prothrombinex-VF in a patient with a mechanical aortic valve. ( 26224191 )
2015
41
Brachial artery mycotic aneurysm and splenic infarction associated with infective endocarditis. ( 26186921 )
2015
42
Evaluation with contrast ultrasound of the prevalence of splenic infarction in left-sided infective endocarditis. ( 26261464 )
2015
43
Splenic infarction associated with sickle cell trait at low altitude. ( 26133225 )
2015
44
Acute Splenic Infarction at an Academic General Hospital Over 10 Years: Presentation, Etiology, and Outcome. ( 26356690 )
2015
45
Splenic infarction - A rare cause of acute abdominal pain following gastric surgery: A case series. ( 25818369 )
2015
46
Incidentally Discovered Splenic Infarction Associated with Scrub Typhus. ( 26333728 )
2015
47
Splenic infarction and G-CSF. ( 26840787 )
2015
48
Splenic Infarction in Polycythemia Vera: Can the Spleen be Saved? ( 26731841 )
2015
49
Massive splenic infarction leading to sickle cell disease. ( 25075666 )
2014
50
Splenic infarction in Plasmodium vivax malaria. ( 24825280 )
2014

Variations for Splenic Infarction

Expression for Splenic Infarction

Search GEO for disease gene expression data for Splenic Infarction.

Pathways for Splenic Infarction

GO Terms for Splenic Infarction

Cellular components related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 APOH HBB SAA1 STK10
2 extracellular space GO:0005615 9.46 APOH CPA1 HBB SAA1
3 high-density lipoprotein particle GO:0034364 8.96 APOH SAA1
4 endocytic vesicle lumen GO:0071682 8.62 HBB SAA1

Biological processes related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 8.62 HBB SAA1

Molecular functions related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.62 APOH SAA1

Sources for Splenic Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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