Splenic Infarction disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)

MalaCards based summary: Splenic Infarction, also known as infarct of the spleen, is related to sickle cell anemia and thrombophilia due to thrombin defect. An important gene associated with Splenic Infarction is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Defects of contact activation system (CAS) and kallikrein/kinin system (KKS). Affiliated tissues include spleen, liver and lymph node, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia: ⁷⁵ Splenic infarction is a condition in which blood flow supply to the spleen is compromised, leading to... more...

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Related Diseases for Splenic Infarction

Diseases related to Splenic Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 753)

#	Related Disease	Score	Top Affiliating Genes
1	sickle cell anemia	30.6	SERPINC1 HP HBB F3 F2 CYGB
2	thrombophilia due to thrombin defect	30.5	SERPINC1 F3 F2 APOH
3	endocarditis	30.5	SERPINC1 F2 CRP APOH ALB
4	thrombosis	30.5	SERPINC1 JAK2 F3 F2 APOH
5	protein c deficiency	30.3	SERPINC1 F2 APOH
6	scrub typhus	30.3	GPT F3 CRP
7	polycythemia	30.3	JAK2 HBB F3 F2 CRP
8	antiphospholipid syndrome	30.3	SERPINC1 F3 F2 CRP APOH
9	endemic typhus	30.3	GPT CRP
10	splenic abscess	30.2	GPT F3 F2 CRP ALB
11	acute pancreatitis	30.2	MPO GPT CRP
12	epidemic typhus	30.2	GPT CRP ALB
13	spotted fever	30.2	GPT F3 CRP
14	heparin-induced thrombocytopenia	30.1	F3 F2
15	microscopic polyangiitis	30.1	PRTN3 MPO
16	neurosarcoidosis	30.1	PRTN3 CRP
17	granulomatosis with polyangiitis	30.1	PRTN3 MPO CRP
18	hemoglobinuria	30.0	SERPINC1 HP F2
19	protein s deficiency	30.0	SERPINC1 F3 F2 APOH
20	vasculitis	30.0	PRTN3 MPO CRP APOH
21	pyoderma	30.0	F3 CRP APOH
22	chronic intestinal vascular insufficiency	30.0	CRP ALB
23	vitamin k deficiency bleeding	30.0	SERPINC1 F3 F2
24	purpura	29.9	SERPINC1 F3 F2 CRP APOH
25	infective endocarditis	29.9	PRTN3 MPO F3 F2 CRP ALB
26	portal hypertension	29.9	JAK2 GPT F2 ALB
27	babesiosis	29.9	HP GPT CRP ALB
28	disseminated intravascular coagulation	29.9	SERPINC1 GPT F3 F2 CRP
29	pyelonephritis	29.9	GPT CRP ALB
30	evans' syndrome	29.9	U2AF1 HP APOH
31	severe acute respiratory syndrome	29.9	GPT F3 CRP
32	toxic shock syndrome	29.9	SERPINC1 F3 CRP
33	acquired polycythemia	29.9	JAK2 F3 CYGB
34	thrombophilia	29.9	SERPINC1 JAK2 F3 F2 APOH
35	polyarteritis nodosa	29.9	PRTN3 MPO GPT CRP APOH
36	hemolytic anemia	29.8	U2AF1 HP HBB F3 APOH ALB
37	critical covid-19	29.8	GPT F3 F2 CRP
38	limb ischemia	29.8	SERPINC1 F3 CRP ALB
39	arteriovenous malformation	29.8	F3 F2 ALB
40	viral pneumonia	29.7	GPT F3 F2 CRP
41	diabetes mellitus, ketosis-prone	29.7	GPT CRP ALB
42	hernia, hiatus	29.7	CRP ALB
43	apnea, obstructive sleep	29.7	GPT CRP ALB
44	hemophagocytic lymphohistiocytosis	29.7	U2AF1 GPT F3 CRP
45	alcoholic liver cirrhosis	29.7	GPT F2 ALB
46	dengue hemorrhagic fever	29.7	GPT F3 ALB
47	biliary atresia	29.7	GPT F2 ALB
48	meningitis	29.7	MPO CRP ALB
49	bowel dysfunction	29.7	GPT CRP ALB
50	pulmonary edema	29.7	SERPINC1 HP F2 CRP

Graphical network of the top 20 diseases related to Splenic Infarction:

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Symptoms & Phenotypes for Splenic Infarction

MGI Mouse Phenotypes related to Splenic Infarction:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.03	ALB APOH CRP CYGB F2 F3
2	muscle	MP:0005369	9.87	ALB CYGB F2 F3 HBB MPO
3	neoplasm	MP:0002006	9.85	ALB CYGB F3 HP JAK2 U2AF1
4	cardiovascular system	MP:0005385	9.85	ALB CRP CYGB F2 F3 HP
5	immune system	MP:0005387	9.73	ALB CD5 CRP F2 F3 HBB
6	hematopoietic system	MP:0005397	9.32	CD5 F2 F3 HBB HP JAK2

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Drugs & Therapeutics for Splenic Infarction

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Compare the Effects of Volume-oriented Versus Flow-oriented Incentive Spirometry on Pulmonary Function and Functional Capacity in Patients of Upper Abdominal Laparoscopic Surgery	Completed	NCT04716166

Search NIH Clinical Center for Splenic Infarction

Cochrane evidence based reviews: splenic infarction

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Genetic Tests for Splenic Infarction

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Anatomical Context for Splenic Infarction

Organs/tissues related to Splenic Infarction:

MalaCards : Spleen, Liver, Lymph Node, Pancreas, Bone Marrow, Myeloid, Heart

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Publications for Splenic Infarction

Articles related to Splenic Infarction:

(show top 50) (show all 1318)

#	Title	Authors	PMID	Year
1	[A case of acute pancreatitis and splenic infarction associated with antiphospholipid syndrome]. ⁵³ ⁶²	Koh KH...Kim JH	19158473	2009
2	Splenic infarction in a pregnant woman with systemic lupus erythematosus. ⁵³ ⁶²	Soy M...Unlu E	15714383	2005
3	Splenic infarction associated with anti-cardiolipin antibody: a report of two cases. ⁵³ ⁶²	McVay CL...Silberman AW	14964553	2004
4	[Splenic infarction in a patient with anticardiolipin antibodies and leptospirosis]. ⁵³ ⁶²	Noval J...Baro U	10193074	1999
5	Splenic infarction associated with anticardiolipin antibodies in a patient with acquired immunodeficiency syndrome. ⁵³ ⁶²	Cappell MS...Tiku M	8508712	1993
6	Splenic artery pseudoaneurysm resulting from gastric ulcer presenting acute upper gastrointestinal bleeding. ⁶²	Okumura T...Umemura T	36324839	2023
7	Splenic Infarction in Patients with Philadelphia-negative Myeloproliferative Neoplasms. ⁶²	Lee MW...Jo DY	35527026	2022
8	Commentary on "Gallstone associated celiac trunk thromboembolisms complicated with splenic infarction: A case report''. ⁶²	Tokur O...Kantarci M	36405298	2022
9	A floating mural thrombus in the ascending aorta can cause multiorgan infarction. ⁶²	Hirata R...Hirakawa Y	36328361	2022
10	A subacute presentation of Mycoplasma hominis prosthetic valve endocarditis. ⁶²	Kim MGJ...Post J	36319037	2022
11	Cytomegalovirus-associated splenic infarction in rheumatoid arthritis. ⁶²	Azuma N...Matsui K	36423785	2022
12	Comparing the Warshaw technique with vessel-preservation in laparoscopic spleen preserving distal pancreatectomy: is there a better approach? ⁶²	Zhu A...Jayaraman S	36257873	2022
13	Robotic real-time vessel navigation using indocyanine green fluorescence for lymph node dissection along the left gastroepiploic vessels during robotic distal gastrectomy - First experience. ⁶²	Ebihara Y...Hirano S	36204945	2022
14	Bilateral Renal Artery Thrombosis: A Case of Successful Kidney Recovery After Prolonged Anuria. ⁶²	Lemos Mendes MF...Marques S	36381786	2022
15	Laparoscopic D3 oncological resection in splenic flexure cancer: Technical details and its impact on long-term survival. ⁶²	Rusli SM...Kim SH	36281503	2022
16	A New Insight Into Nonbacterial Thrombotic Endocarditis: A Systematic Review of Cases. ⁶²	Venepally NR...Mookadam F	36052565	2022
17	Thromboembolism in children with multisystem inflammatory syndrome: a literature review. ⁶²	Menon NM...Srivaths LV	35031708	2022
18	Granulomatosis With Polyangiitis Complicated by Diffuse Alveolar Hemorrhage, Splenic Infarction and Stroke. ⁶²	Zhang K...Trivedi P	36381831	2022
19	Efficacy and safety of splenic artery embolization for intractable ascites using Amplatzer vascular plug versus coil after living donor liver transplantation. ⁶²	Lee CY...Ou HY	36218150	2022
20	A Rare and Interesting Presentation of Diabetic Ketoacidosis Caused by Native Aortic Valve Endocarditis Complicated by Aortic Root Abscess Resulting in Multiple Septic Emboli Causing Bowel Ischemia and Splenic Infarction. ⁶²	Vinod VC...Mlawa G	36262944	2022
21	Gallstone associated celiac trunk thromboembolisms complicated with splenic infarction: A case report. ⁶²	Wu CY...Wang CC	36157657	2022
22	Can Empirical Segmental Angioembolization of Splenic Artery Salvage Pancreatic Intraluminal Bleed? ⁶²	Sreejith S...Jayadevan ER	36177284	2022
23	Infective endocarditis on interventricular communication as cause of massive haemoptysis: a case report. ⁶²	Rodriguez Torres DJ...Orta RG	36106132	2022
24	A Mobile Thrombus of the Thoracic Aorta. ⁶²	Wolf A...Shehab M	36169285	2022
25	Complications Following Splenic Embolization for Trauma: Have Things Changed Over Time? ⁶²	Entriken C...Ekeh AP	35460920	2022
26	Celiac Trunk Thrombosis a Rare Cause of Acute Abdomen. Case Presentation. ⁶²	Alharbi M...Alharbi AM	36324364	2022
27	Antiphospholipid syndrome with renal and splenic infarction after blunt trauma: A case report. ⁶²	Lee NA...Jo YG	36159402	2022
28	Wandering spleen with torsion and infarction: A case report. ⁶²	Lugo-Fagundo E...Fishman EK	35874869	2022
29	Refractory Salmonella Prosthetic Valve Endocarditis Complicated by Splenic Infarction and Aortic Pseudoaneurysm in a Patient with Double Prosthetic Valves: A Case Report. ⁶²	Alhamadh MS...Al-Ghamdi MG	36010333	2022
30	Polyarteritis nodosa presenting with posterior reversible leukoencephalopathy syndrome. ⁶²	Heartshorne R...Alusi S	36129358	2022
31	Splenic infarction due to Mycobacterium avium complex infection in an HIV-infected patient with immune reconstitution failure: a case report. ⁶²	Wang Y...Wen Y	35899913	2022
32	A Unique Case of Nonhypoxic Splenic Infarction in a Patient With Sickle Cell Trait Due to Dehydration and Sepsis From a Dental Infection: A Case Report. ⁶²	Chaughtai S...Asif A	35949746	2022
33	Secondary Complications in COVID-19 Patients: A Case Series. ⁶²	Belfiore MP...Cappabianca S	35894019	2022
34	Splenic vessels preserving versus Warshaw technique in spleen preserving distal pancreatectomy: A systematic review and meta-analysis. ⁶²	Hang K...Li K	35605839	2022
35	Incidental and Asymptomatic Splenic Infarction and Infrarenal Thrombus in a COVID-19 Patient. ⁶²	Childers J...Akella R	35936145	2022
36	Post-COVID-19 splenic infarction in a patient with chronic atrial fibrillation: A case report. ⁶²	Sarmadian R...Hassani S	35846926	2022
37	Diagnosis and treatment of splenic torsion in children: preoperative thrombocytosis predicts splenic infarction. ⁶²	Wang Z...Chen Y	35864485	2022
38	Celiac Artery Thrombosis and Splenic Infarction as a Consequence of Mild COVID-19 Infection: Report of an Unusual Case. ⁶²	Arslan G	34198348	2022
39	Spontaneous isolated celiac and splenic artery dissection with splenic infarction. ⁶²	Pateman Aciu S...Fisher J	35464790	2022
40	Thrombosis leading to acute abdomen in corona virus disease- 19:A case series. ⁶²	Hashim Z...Mohindra S	35907170	2022
41	Splenic volvulus on ectopic spleen in adults: A case report. ⁶²	Ouazzani LCE...Chikhaoui N	35479965	2022
42	Concurrent Cerebral, Splenic, and Renal Infarction in a Patient With COVID-19 Infection. ⁶²	Rigual R...Diez-Tejedor E	34855656	2022
43	Acute complete splenic infarction secondary to COVID-19 infection. ⁶²	Javaid U...Bhargava P	35242265	2022
44	Robotic real-time vessel navigation using indocyanine green fluorescence for lymph node dissection along the left gastroepiploic vessels during robotic distal gastrectomy First experience. ⁶²	Ebihara Y...Hirano S	35661007	2022
45	Readmission after splenic salvage: How real is the risk? ⁶²	Santorelli JE...Godat LN	34857387	2022
46	Steroid-Induced Tumor Lysis Syndrome Accompanied by Diabetic Ketoacidosis and Acute Renal Failure in a Non-Hodgkin Lymphoma Patient. ⁶²	Cao K...Ganti L	35651382	2022
47	Splenic Infarction Diagnosed by Contrast-enhanced Ultrasound in Infectious Mononucleosis - An Appropriate Diagnostic Option: A Case Report with Review of the Literature. ⁶²	Reichlin M...Minotti B	35832357	2022
48	Splenic infarction after Epstein-Barr virus infection in a patient with hereditary spherocytosis: a case report and literature review. ⁶²	Ma Z...Yu H	35397569	2022
49	Hepatic Infarction in a Patient With Sickle Cell Trait Presenting With HELLP Syndrome. ⁶²	Paudel AC...Khanal S	35506117	2022
50	Acute Cytomegalovirus Infection Associated With Splenic Infarction: A Case Report and Review of the Literature. ⁶²	Blackwood GA...Gett R	35475102	2022

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Genes for Splenic Infarction

Genes related to Splenic Infarction (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	HBB	Hemoglobin Subunit Beta	Protein Coding	12.58	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	APOH	Apolipoprotein H	Protein Coding	11.54	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8508712 10193074 15714383 (more) 14964553 19158473
3	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	8.12	DISEASES inferred ¹⁴ ¹⁴
4	F2	Coagulation Factor II, Thrombin	Protein Coding	6.73	DISEASES inferred ¹⁴
5	CRP	C-Reactive Protein	Protein Coding	6.58	DISEASES inferred ¹⁴
6	F3	Coagulation Factor III, Tissue Factor	Protein Coding	6.57	DISEASES inferred ¹⁴
7	SERPINC1	Serpin Family C Member 1	Protein Coding	6.21	DISEASES inferred ¹⁴
8	JAK2	Janus Kinase 2	Protein Coding	5.84	DISEASES inferred ¹⁴
9	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	5.52	DISEASES inferred ¹⁴
10	PRTN3	Proteinase 3	Protein Coding	5.43	DISEASES inferred ¹⁴
11	HP	Haptoglobin	Protein Coding	5.21	DISEASES inferred ¹⁴
12	ALB	Albumin	Protein Coding	5.12	DISEASES inferred ¹⁴
13	CYGB	Cytoglobin	Protein Coding	5.05	DISEASES inferred ¹⁴
14	CD5	CD5 Molecule	Protein Coding	5.01	DISEASES inferred ¹⁴
15	MPO	Myeloperoxidase	Protein Coding	4.98	DISEASES inferred ¹⁴

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Variations for Splenic Infarction

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Expression for Splenic Infarction

Search GEO for disease gene expression data for Splenic Infarction.

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Pathways for Splenic Infarction

Pathways related to Splenic Infarction according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.29	SERPINC1 PRTN3 JAK2 HBB F3 F2
2	Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) ⁶⁶ Show member pathways Blood clotting cascade ⁷⁴ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Complement and coagulation cascades ⁷⁴ Defective F8 binding to von Willebrand factor ⁶⁶ Defective F8 cleavage by thrombin ⁶⁶ Defective F8 sulfation at Y1699 ⁶⁶ Defective F9 activation ⁶⁶ Defective F9 secretion ⁶⁶ Defective factor IX causes hemophilia B ⁶⁶ Defective factor VIII causes hemophilia A ⁶⁶ Defective factor XII causes hereditary angioedema ⁶⁶ Defective gamma-carboxylation of F9 ⁶⁶ Diseases of hemostasis ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶ Thrombin/protease-activated receptor (PAR) pathway ⁶¹	11.72	SERPINC1 PRTN3 F3 F2
3	Binding and Uptake of Ligands by Scavenger Receptors ⁶⁶ Show member pathways Scavenging by Class A Receptors ⁶⁶ Scavenging by Class B Receptors ⁶⁶ Scavenging by Class F Receptors ⁶⁶ Scavenging by Class H Receptors ⁶⁶ Scavenging of heme from plasma ⁶⁶	11.29	HP HBB ALB

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GO Terms for Splenic Infarction

Cellular components related to Splenic Infarction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.13	SERPINC1 PRTN3 MPO HP HBB F3
2	collagen-containing extracellular matrix	GO:0062023	9.96	SERPINC1 PRTN3 F3 F2 APOH
3	blood microparticle	GO:0072562	9.65	ALB F2 HBB HP SERPINC1
4	extracellular space	GO:0005615	9.64	SERPINC1 PRTN3 MPO HP HBB GPT

Biological processes related to Splenic Infarction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	acute-phase response	GO:0006953	9.73	HP F2 CRP
2	hemostasis	GO:0007599	9.33	SERPINC1 F3 F2
3	cellular oxidant detoxification	GO:0098869	9.28	MPO HP HBB CYGB ALB
4	regulation of blood coagulation	GO:0030193	9.26	SERPINC1 F2 APOH

Molecular functions related to Splenic Infarction according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:0004252	9.97	PRTN3 HP F3 F2
2	heparin binding	GO:0008201	9.92	SERPINC1 MPO F2 APOH
3	heme binding	GO:0020037	9.76	MPO JAK2 HBB CYGB
4	hemoglobin binding	GO:0030492	9.56	HP HBB
5	peroxidase activity	GO:0004601	9.43	MPO HBB CYGB
6	oxygen binding	GO:0019825	9.1	HBB CYGB ALB

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Sources for Splenic Infarction

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

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⁸ Cosmic

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¹¹ Disease Ontology

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¹⁵ DrugBank

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¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

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³³ ICD11

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³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

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⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SPL006 MIFTS: 39	Splenic Infarction Categories: Blood diseases, Cardiovascular diseases, Immune diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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