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MCID: SPL006
MIFTS: 38

Splenic Infarction

Categories: Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Splenic Infarction

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MalaCards integrated aliases for Splenic Infarction:

Name: Splenic Infarction 12 56 45 15 17 74
Infarct of the Spleen 54
Splenic Infarcts 54
Splenic Infarct 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:2533
MeSH 45 D013159
SNOMED-CT 69 22996003
ICD10 34 D73.5
UMLS 74 C0037998
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Summaries for Splenic Infarction

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MalaCards based summary : Splenic Infarction, also known as infarct of the spleen, is related to hemoglobin se disease and sickle cell - hemoglobin d disease. An important gene associated with Splenic Infarction is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Heparin and Calcium have been mentioned in the context of this disorder. Affiliated tissues include spleen, b cells and liver.

Wikipedia : 77 Splenic infarction is a condition in which blood flow supply to the spleen is compromised, leading to... more...

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Related Diseases for Splenic Infarction

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Diseases related to Splenic Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 hemoglobin se disease 11.6
2 sickle cell - hemoglobin d disease 11.3
3 malaria 10.3
4 thrombosis 10.3
5 endocarditis 10.3
6 pfeiffer syndrome 10.2
7 pancreatitis 10.2
8 infective endocarditis 10.1
9 hereditary spherocytosis 10.1
10 varicose veins 10.1
11 acute pancreatitis 10.1
12 polycythemia vera 10.1
13 sickle cell anemia 10.1
14 leukemia 10.1
15 lymphoma 10.1
16 antiphospholipid syndrome 10.1
17 polycythemia 10.1
18 thrombophilia due to thrombin defect 10.0
19 anemia, autoimmune hemolytic 10.0
20 hemolytic anemia 10.0
21 peritonitis 10.0
22 sickle cell disease 10.0
23 systemic lupus erythematosus 10.0
24 pancreatic cancer 10.0
25 thrombocytopenia 10.0
26 epidemic typhus 10.0
27 splenic sequestration 10.0
28 plasmodium vivax malaria 10.0
29 scrub typhus 10.0
30 hemoglobin c disease 10.0
31 protein c deficiency 10.0
32 lupus erythematosus 10.0
33 pulmonary embolism 10.0
34 polyarteritis nodosa 10.0
35 splenomegaly 10.0
36 cytomegalovirus infection 10.0
37 sarcoidosis 1 9.9
38 granulomatosis with polyangiitis 9.9
39 gastric cancer 9.9
40 liver cirrhosis 9.9
41 paroxysmal nocturnal hemoglobinuria 9.9
42 thalassemia 9.9
43 visceral heterotaxy 9.9
44 atrial fibrillation 9.9
45 lymphocytic leukemia 9.9
46 portal hypertension 9.9
47 gastric ulcer 9.9
48 brucellosis 9.9
49 q fever 9.9
50 splenic artery aneurysm 9.9

Graphical network of the top 20 diseases related to Splenic Infarction:



Diseases related to Splenic Infarction
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Symptoms & Phenotypes for Splenic Infarction

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Drugs & Therapeutics for Splenic Infarction

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Drugs for Splenic Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 2 9005-49-6 46507594 772
2
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
3 Anticoagulants Phase 2
4 calcium heparin Phase 2
5 Fibrinolytic Agents Phase 2
6 Calcium, Dietary Phase 2
7 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HEROIC (Heparin Requirement in Counterpulsation) Terminated NCT00445211 Phase 2 Heparin
2 Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Unknown status NCT02261584 Not Applicable

Search NIH Clinical Center for Splenic Infarction

Cochrane evidence based reviews: splenic infarction

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Genetic Tests for Splenic Infarction

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Anatomical Context for Splenic Infarction

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MalaCards organs/tissues related to Splenic Infarction:

42
Spleen, B Cells, Liver, Myeloid, Kidney, Pancreas
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Publications for Splenic Infarction

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Articles related to Splenic Infarction:

(show top 50) (show all 314)
# Title Authors Year
1
Splenic infarction as a rare presentation of severe babesiosis. ( 30740305 )
2019
2
Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy Regimen. ( 30906610 )
2019
3
Splenic Marginal Zone B-Cell Lymphoma With Splenic Infarction in a Patient With Cold Agglutinin Disease. ( 30888998 )
2019
4
Massive Splenic Infarction in a Child With Sickle Cell Disease on Chronic Transfusion Therapy. ( 30499910 )
2019
5
Splenic infarction induced by epstein-barr virus infection in a patient with sickle cell trait. ( 30746887 )
2019
6
Splenic infarction from vascular torsion in a child with normal splenic anatomy. ( 31092484 )
2019
7
Splenic Infarction as Only Manifestation of Antiphospholipid Syndrome in a Patient With Rheumatoid Arthritis. ( 30601167 )
2018
8
Splenic infarction due to cytomegalovirus infection in an immunocompetent patient. ( 30502300 )
2018
9
The comorbidity of acute ischemic stroke and splenic infarction resulting from essential thrombocythemia. ( 29984396 )
2018
10
Splenic artery pseudoaneurysm with splenic infarction induced by a benign gastric ulcer: A case report. ( 30024561 )
2018
11
Acute Gastritis and Splenic Infarction Caused by Epstein-Barr Virus. ( 29713613 )
2018
12
A Case of Scrub Typhus complicated with a Splenic Infarction. ( 29637756 )
2018
13
Splenic infarction associated with acute infectious mononucleosis. ( 28480876 )
2018
14
Ischemic Necrosis of the Gastric Remnant without Splenic Infarction Following Subtotal Gastrectomy. ( 28835094 )
2018
15
Splenic infarction due a common infection. ( 29078991 )
2018
16
Splenic Infarction as a Delayed Febrile Complication Following Radical Gastrectomy for Gastric Cancer Patients: Computed Tomography-Based Analysis. ( 29270657 )
2018
17
Splenic Infarction: An Under-recognized Complication of Infectious Mononucleosis? ( 29577060 )
2018
18
A case of complete splenic infarction after laparoscopic spleen-preserving distal pancreatectomy. ( 29636057 )
2018
19
College Football: Conditioning Them to Death; Splenic Infarction: Keeping it in the Family. ( 30204628 )
2018
20
Unusual Complications From Babesia Infection: Splenic Infarction and Splenic Rupture in Two Separate Patients. ( 30253953 )
2018
21
Spontaneous Celiac Artery Dissection Presenting With Splenic Infarction: A Case Report. ( 30344811 )
2018
22
Renal and Splenic Infarction in a Patient with Familial Hypercholesterolemia and Previous Cerebral Infarction. ( 30531677 )
2018
23
Splenic Infarction in Acute Cytomegalovirus and Human Parvovirus Concomitant Infection. ( 30631613 )
2018
24
Acute Pancreatitis with Splenic Infarction as Early Postoperative Complication following Laparoscopic Sleeve Gastrectomy. ( 28487807 )
2017
25
Transient antiphospholipid syndrome and splenic infarction in a patient with parvovirus B19 acute infection. ( 28602215 )
2017
26
Streptococcus agalactiae infective endocarditis complicated by multiple mycotic hepatic aneurysms and massive splenic infarction: a case report. ( 29284415 )
2017
27
Splenic Infarction and Rupture Due to Melioidosis. ( 29208262 )
2017
28
Splenic infarction associated with acute infectious mononucleosis due to Epstein-Barr virus infection. ( 27357912 )
2017
29
Splenic Infarction as Starting Symptom in Minimal Change Nephropathy. ( 28229998 )
2017
30
Image Diagnosis: Splenic Infarction Associated with Oral Contraceptive Pills in a Healthy Young Woman. ( 28488992 )
2017
31
Pulmonary arteriovenous malformations complicated by splenic infarction and abscess. ( 28736615 )
2017
32
Long-term follow up of a massive, conservatively treated, splenic infarction in a young adolescent. ( 29044906 )
2017
33
Splenic Infarction in Two Members of the Family with Sickle Cell Trait: A Case Report of Rare Complication. ( 29308370 )
2017
34
AN UNUSUAL CAUSE OF ACUTE ABDOMEN: SPLENIC INFARCTION. ( 29340557 )
2017
35
Left superior pulmonary venous thrombosis complicated with splenic infarction after video-assisted thoracoscopic left upper lobectomy. ( 30279783 )
2017
36
A case of cytomegalovirus infection with splenic infarction and an esophageal ulcer in an immunocompetent adult. ( 28679983 )
2017
37
A Diagnostic Pitfall: Salmonella Splenic Infarction in Hereditary Spherocytosis. ( 26272774 )
2016
38
Sequential Insults: Acute Lyme Disease with Splenic Infarction. ( 26688425 )
2016
39
Splenic Infarction in Acute Infectious Mononucleosis. ( 26602427 )
2016
40
Splenic infarction as a pitfall on labeled red blood cell imaging. ( 26917904 )
2016
41
A Case of Isolated Celiac Artery Dissection Accompanied by Splenic Infarction Detected by Ultrasonography in the Emergency Department. ( 27148460 )
2016
42
Massive splenic infarction and splenic venous thrombosis observed in a patient with acute splenic syndrome of sickle cell traits on contrast-enhanced thin-slice computed tomography. ( 27251735 )
2016
43
Evaluation with contrast ultrasound of the prevalence of splenic infarction in left-sided infective endocarditis. ( 26261464 )
2015
44
Brachial artery mycotic aneurysm and splenic infarction associated with infective endocarditis. ( 26186921 )
2015
45
An adolescent with hereditary spherocytosis who presented with splenic infarction. ( 26139647 )
2015
46
Mycosis fungoides associated with splenic infarction and muscle involvement. ( 25994394 )
2015
47
Splenic Infarction in Polycythemia Vera: Can the Spleen be Saved? ( 26731841 )
2015
48
Incidentally Discovered Splenic Infarction Associated with Scrub Typhus. ( 26333728 )
2015
49
Splenic infarction associated with sickle cell trait at low altitude. ( 26133225 )
2015
50
Splenic infarction after reversal of warfarin using Prothrombinex-VF in a patient with a mechanical aortic valve. ( 26224191 )
2015
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Variations for Splenic Infarction

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Expression for Splenic Infarction

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Search GEO for disease gene expression data for Splenic Infarction.
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Pathways for Splenic Infarction

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Pathways related to Splenic Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 12.41 APOH HBB SERPINA3
2
Selenium Micronutrient Network 1
Show member pathways
 11.13 HBB SAA1 SERPINA3
3
Binding and Uptake of Ligands by Scavenger Receptors 67
Show member pathways
 10.97 HBB SAA1
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GO Terms for Splenic Infarction

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Cellular components related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.67 APOH HBB SAA1 SERPINA3
2 extracellular region GO:0005576 9.65 APOH CPA1 HBB SAA1 SERPINA3
3 collagen-containing extracellular matrix GO:0062023 9.4 APOH SERPINA3
4 extracellular space GO:0005615 9.35 APOH CPA1 HBB SAA1 SERPINA3
5 blood microparticle GO:0072562 9.32 HBB SERPINA3
6 high-density lipoprotein particle GO:0034364 9.16 APOH SAA1
7 endocytic vesicle lumen GO:0071682 8.62 HBB SAA1

Biological processes related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.16 HBB SAA1
2 platelet degranulation GO:0002576 8.96 APOH SERPINA3
3 acute-phase response GO:0006953 8.62 SAA1 SERPINA3

Molecular functions related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.62 APOH SAA1
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Sources for Splenic Infarction

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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