MCID: SPL006
MIFTS: 39

Splenic Infarction

Categories: Blood diseases, Cardiovascular diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Splenic Infarction

MalaCards integrated aliases for Splenic Infarction:

Name: Splenic Infarction 11 53 43 14 16 71 75
Infarct of the Spleen 19
Splenic Infarcts 19
Splenic Infarct 11

Classifications:



External Ids:

Disease Ontology 11 DOID:2533
MeSH 43 D013159
SNOMED-CT 68 22996003
ICD10 31 D73.5
UMLS 71 C0037998

Summaries for Splenic Infarction

GARD: 19 Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)

MalaCards based summary: Splenic Infarction, also known as infarct of the spleen, is related to sickle cell anemia and thrombophilia due to thrombin defect. An important gene associated with Splenic Infarction is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. Affiliated tissues include spleen, liver and lymph node, and related phenotypes are homeostasis/metabolism and muscle

Wikipedia: 75 Splenic infarction is a condition in which blood flow supply to the spleen is compromised, leading to... more...

Related Diseases for Splenic Infarction

Diseases related to Splenic Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 752)
# Related Disease Score Top Affiliating Genes
1 sickle cell anemia 30.6 SERPINC1 HP HBB F3 F2 CYGB
2 thrombophilia due to thrombin defect 30.5 SERPINC1 F3 F2 APOH
3 endocarditis 30.5 SERPINC1 F2 CRP APOH ALB
4 thrombosis 30.5 SERPINC1 JAK2 F3 F2 APOH
5 protein c deficiency 30.3 SERPINC1 F2 APOH
6 scrub typhus 30.3 GPT F3 CRP
7 polycythemia 30.3 JAK2 HBB F3 F2 CRP
8 antiphospholipid syndrome 30.3 SERPINC1 F3 F2 CRP APOH
9 endemic typhus 30.3 GPT CRP
10 splenic abscess 30.2 GPT F3 F2 CRP ALB
11 neutrophilia, hereditary 30.2 U2AF1 MPO JAK2 CRP
12 acute pancreatitis 30.2 MPO GPT CRP
13 epidemic typhus 30.2 GPT CRP ALB
14 spotted fever 30.2 GPT F3 CRP
15 heparin-induced thrombocytopenia 30.1 F3 F2
16 microscopic polyangiitis 30.1 PRTN3 MPO
17 neurosarcoidosis 30.1 PRTN3 CRP
18 hemoglobinuria 30.0 SERPINC1 HP F2
19 protein s deficiency 30.0 SERPINC1 F3 F2 APOH
20 pyoderma 30.0 F3 CRP APOH
21 chronic intestinal vascular insufficiency 30.0 CRP ALB
22 granulomatosis with polyangiitis 30.0 PRTN3 MPO CRP
23 vitamin k deficiency bleeding 30.0 SERPINC1 F3 F2
24 purpura 29.9 SERPINC1 F3 F2 CRP APOH
25 portal hypertension 29.9 JAK2 GPT F2 ALB
26 infective endocarditis 29.9 PRTN3 MPO F3 F2 CRP ALB
27 babesiosis 29.9 HP GPT CRP ALB
28 disseminated intravascular coagulation 29.9 SERPINC1 GPT F3 F2 CRP
29 pyelonephritis 29.9 GPT CRP ALB
30 vasculitis 29.9 PRTN3 MPO CRP APOH
31 evans' syndrome 29.9 U2AF1 HP APOH
32 severe acute respiratory syndrome 29.9 GPT F3 CRP
33 toxic shock syndrome 29.9 SERPINC1 F3 CRP
34 acquired polycythemia 29.9 JAK2 F3 CYGB
35 thrombophilia 29.9 SERPINC1 JAK2 F3 F2 APOH
36 hemolytic anemia 29.8 U2AF1 HP HBB F3 APOH ALB
37 critical covid-19 29.8 GPT F3 F2 CRP
38 polyarteritis nodosa 29.8 PRTN3 MPO GPT CRP APOH
39 limb ischemia 29.8 SERPINC1 F3 CRP ALB
40 arteriovenous malformation 29.8 F3 F2 ALB
41 viral pneumonia 29.7 GPT F3 F2 CRP
42 diabetes mellitus, ketosis-prone 29.7 GPT CRP ALB
43 hernia, hiatus 29.7 CRP ALB
44 apnea, obstructive sleep 29.7 GPT CRP ALB
45 hemophagocytic lymphohistiocytosis 29.7 U2AF1 GPT F3 CRP
46 alcoholic liver cirrhosis 29.7 GPT F2 ALB
47 dengue hemorrhagic fever 29.7 GPT F3 ALB
48 meningitis 29.7 MPO CRP ALB
49 biliary atresia 29.7 GPT F2 ALB
50 pulmonary edema 29.7 SERPINC1 HP F2 CRP

Graphical network of the top 20 diseases related to Splenic Infarction:



Diseases related to Splenic Infarction

Symptoms & Phenotypes for Splenic Infarction

MGI Mouse Phenotypes related to Splenic Infarction:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ALB APOH CRP CYGB F2 F3
2 muscle MP:0005369 9.87 ALB CYGB F2 F3 HBB MPO
3 neoplasm MP:0002006 9.85 ALB CYGB F3 HP JAK2 U2AF1
4 cardiovascular system MP:0005385 9.85 ALB CRP CYGB F2 F3 HP
5 immune system MP:0005387 9.73 ALB CD5 CRP F2 F3 HBB
6 hematopoietic system MP:0005397 9.32 CD5 F2 F3 HBB HP JAK2

Drugs & Therapeutics for Splenic Infarction

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Compare the Effects of Volume-oriented Versus Flow-oriented Incentive Spirometry on Pulmonary Function and Functional Capacity in Patients of Upper Abdominal Laparoscopic Surgery Completed NCT04716166

Search NIH Clinical Center for Splenic Infarction

Cochrane evidence based reviews: splenic infarction

Genetic Tests for Splenic Infarction

Anatomical Context for Splenic Infarction

Organs/tissues related to Splenic Infarction:

MalaCards : Spleen, Liver, Lymph Node, Pancreas, Bone Marrow, Myeloid, Heart

Publications for Splenic Infarction

Articles related to Splenic Infarction:

(show top 50) (show all 1310)
# Title Authors PMID Year
1
[A case of acute pancreatitis and splenic infarction associated with antiphospholipid syndrome]. 53 62
19158473 2009
2
Splenic infarction in a pregnant woman with systemic lupus erythematosus. 53 62
15714383 2005
3
Splenic infarction associated with anti-cardiolipin antibody: a report of two cases. 53 62
14964553 2004
4
[Splenic infarction in a patient with anticardiolipin antibodies and leptospirosis]. 53 62
10193074 1999
5
Splenic infarction associated with anticardiolipin antibodies in a patient with acquired immunodeficiency syndrome. 53 62
8508712 1993
6
MDS-408 Partial Splenic Embolization in Patients With Myelodysplastic Syndrome and Myelofibrosis. 62
36163956 2022
7
Thromboembolism in children with multisystem inflammatory syndrome: a literature review. 62
35031708 2022
8
A New Insight Into Nonbacterial Thrombotic Endocarditis: A Systematic Review of Cases. 62
36052565 2022
9
Comparing the Warshaw technique with vessel-preservation in laparoscopic spleen preserving distal pancreatectomy: is there a better approach? 62
36257873 2022
10
Robotic real-time vessel navigation using indocyanine green fluorescence for lymph node dissection along the left gastroepiploic vessels during robotic distal gastrectomy - First experience. 62
36204945 2022
11
Wandering spleen with torsion and infarction: A case report. 62
35874869 2022
12
Complications Following Splenic Embolization for Trauma: Have Things Changed Over Time? 62
35460920 2022
13
Antiphospholipid syndrome with renal and splenic infarction after blunt trauma: A case report. 62
36159402 2022
14
A Rare and Interesting Presentation of Diabetic Ketoacidosis Caused by Native Aortic Valve Endocarditis Complicated by Aortic Root Abscess Resulting in Multiple Septic Emboli Causing Bowel Ischemia and Splenic Infarction. 62
36262944 2022
15
A Mobile Thrombus of the Thoracic Aorta. 62
36169285 2022
16
Gallstone associated celiac trunk thromboembolisms complicated with splenic infarction: A case report. 62
36157657 2022
17
Efficacy and safety of splenic artery embolization for intractable ascites using Amplatzer vascular plug versus coil after living donor liver transplantation. 62
36218150 2022
18
Infective endocarditis on interventricular communication as cause of massive haemoptysis: a case report. 62
36106132 2022
19
Can Empirical Segmental Angioembolization of Splenic Artery Salvage Pancreatic Intraluminal Bleed? 62
36177284 2022
20
Polyarteritis nodosa presenting with posterior reversible leukoencephalopathy syndrome. 62
36129358 2022
21
Refractory Salmonella Prosthetic Valve Endocarditis Complicated by Splenic Infarction and Aortic Pseudoaneurysm in a Patient with Double Prosthetic Valves: A Case Report. 62
36010333 2022
22
Splenic infarction due to Mycobacterium avium complex infection in an HIV-infected patient with immune reconstitution failure: a case report. 62
35899913 2022
23
A Unique Case of Nonhypoxic Splenic Infarction in a Patient With Sickle Cell Trait Due to Dehydration and Sepsis From a Dental Infection: A Case Report. 62
35949746 2022
24
Secondary Complications in COVID-19 Patients: A Case Series. 62
35894019 2022
25
Splenic vessels preserving versus Warshaw technique in spleen preserving distal pancreatectomy: A systematic review and meta-analysis. 62
35605839 2022
26
Diagnosis and treatment of splenic torsion in children: preoperative thrombocytosis predicts splenic infarction. 62
35864485 2022
27
Incidental and Asymptomatic Splenic Infarction and Infrarenal Thrombus in a COVID-19 Patient. 62
35936145 2022
28
Post-COVID-19 splenic infarction in a patient with chronic atrial fibrillation: A case report. 62
35846926 2022
29
Spontaneous isolated celiac and splenic artery dissection with splenic infarction. 62
35464790 2022
30
Thrombosis leading to acute abdomen in corona virus disease- 19:A case series. 62
35907170 2022
31
Celiac Artery Thrombosis and Splenic Infarction as a Consequence of Mild COVID-19 Infection: Report of an Unusual Case. 62
34198348 2022
32
Splenic volvulus on ectopic spleen in adults: A case report. 62
35479965 2022
33
Splenic Infarction in Patients with Philadelphia-negative Myeloproliferative Neoplasms. 62
35527026 2022
34
Concurrent Cerebral, Splenic, and Renal Infarction in a Patient With COVID-19 Infection. 62
34855656 2022
35
Robotic real-time vessel navigation using indocyanine green fluorescence for lymph node dissection along the left gastroepiploic vessels during robotic distal gastrectomy First experience. 62
35661007 2022
36
Acute complete splenic infarction secondary to COVID-19 infection. 62
35242265 2022
37
Readmission after splenic salvage: How real is the risk? 62
34857387 2022
38
Splenic Infarction Diagnosed by Contrast-enhanced Ultrasound in Infectious Mononucleosis - An Appropriate Diagnostic Option: A Case Report with Review of the Literature. 62
35832357 2022
39
Splenic infarction after Epstein-Barr virus infection in a patient with hereditary spherocytosis: a case report and literature review. 62
35397569 2022
40
Hepatic Infarction in a Patient With Sickle Cell Trait Presenting With HELLP Syndrome. 62
35506117 2022
41
Steroid-Induced Tumor Lysis Syndrome Accompanied by Diabetic Ketoacidosis and Acute Renal Failure in a Non-Hodgkin Lymphoma Patient. 62
35651382 2022
42
Splenic infarct in a COVID-19 patient under anticoagulant therapy with normal D-dimer levels. 62
35194547 2022
43
Acute Cytomegalovirus Infection Associated With Splenic Infarction: A Case Report and Review of the Literature. 62
35475102 2022
44
Use of dual-energy computed tomography to detect mycoplasma-related pulmonary embolism and splenic infarction. 62
34742676 2022
45
Indocyanine green fluorescence angiography-guided simultaneous laparoscopic distal gastrectomy and spleen-preserving distal pancreatectomy for conserving the gastrosplenic ligament: A case report. 62
35158232 2022
46
Haemophilus Parainfluenzae mural endocarditis with large atrial septal defect and peripheral embolization. 62
35261698 2022
47
Characteristics and surgical outcomes of patients with atraumatic splenic rupture. 62
35209723 2022
48
Gastrointestinal: Lupus enteritis with splenic infarction. 62
34328241 2022
49
A case report of wandering spleen with pedicle torsion and splenic infarction being misdiagnosed as organ inversion complicated with acute appendicitis. 62
36147692 2022
50
Isolated Splenic Infarction: An Initial Manifestation of Postoperative Atrial Fibrillation. 62
35699230 2022

Variations for Splenic Infarction

Expression for Splenic Infarction

Search GEO for disease gene expression data for Splenic Infarction.

Pathways for Splenic Infarction

Pathways related to Splenic Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 SERPINC1 PRTN3 JAK2 HBB F3 F2
2
Show member pathways
11.72 SERPINC1 PRTN3 F3 F2
3
Show member pathways
11.29 HP HBB ALB

GO Terms for Splenic Infarction

Cellular components related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.13 SERPINC1 PRTN3 MPO HP HBB F3
2 collagen-containing extracellular matrix GO:0062023 9.96 SERPINC1 PRTN3 F3 F2 APOH
3 blood microparticle GO:0072562 9.65 ALB F2 HBB HP SERPINC1
4 extracellular space GO:0005615 9.64 SERPINC1 PRTN3 MPO HP HBB GPT

Biological processes related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.73 HP F2 CRP
2 hemostasis GO:0007599 9.33 SERPINC1 F3 F2
3 cellular oxidant detoxification GO:0098869 9.28 MPO HP HBB CYGB ALB
4 regulation of blood coagulation GO:0030193 9.26 SERPINC1 F2 APOH

Molecular functions related to Splenic Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.97 PRTN3 HP F3 F2
2 heparin binding GO:0008201 9.92 SERPINC1 MPO F2 APOH
3 heme binding GO:0020037 9.76 MPO JAK2 HBB CYGB
4 hemoglobin binding GO:0030492 9.56 HP HBB
5 peroxidase activity GO:0004601 9.43 MPO HBB CYGB
6 oxygen binding GO:0019825 9.1 HBB CYGB ALB

Sources for Splenic Infarction

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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