MCID: SPL013
MIFTS: 19

Splenic Manifestation of Leukemia

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Splenic Manifestation of Leukemia

MalaCards integrated aliases for Splenic Manifestation of Leukemia:

Name: Splenic Manifestation of Leukemia 12 15
Splenic Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:710
NCIt 50 C7296
UMLS 70 C1336065

Summaries for Splenic Manifestation of Leukemia

Disease Ontology : 12 A leukemia that is located in the spleen. It results in an enlargement of the leukemia.

MalaCards based summary : Splenic Manifestation of Leukemia, also known as splenic leukemia, is related to deficiency anemia and hemolytic anemia. An important gene associated with Splenic Manifestation of Leukemia is EMB (Embigin). Affiliated tissues include spleen, thymus and ovary, and related phenotypes are Decreased NANOG protein expression and Decreased NANOG protein expression

Related Diseases for Splenic Manifestation of Leukemia

Diseases related to Splenic Manifestation of Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 deficiency anemia 9.8
2 hemolytic anemia 9.8
3 ovary sarcoma 9.6 TCL1B TCL1A
4 lymphoma 9.2 TCL1B TCL1A BCL11B

Symptoms & Phenotypes for Splenic Manifestation of Leukemia

GenomeRNAi Phenotypes related to Splenic Manifestation of Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased NANOG protein expression GR00184-A-3 9.55 TAF7
2 Decreased NANOG protein expression GR00184-A-6 9.55 TAF7 TCL1A
3 Decreased NANOG protein expression GR00184-A-8 9.55 TAF7 TCL1A
4 Decreased POU5F1-GFP protein expression GR00184-A-1 9.35 TAF12 TAF7 TCL1A
5 Decreased POU5F1-GFP protein expression GR00184-A-4 9.35 TAF7 TCL1A
6 Decreased viability after Maraba virus infection GR00252-A-1 9.23 TAF12 TCL1B
7 Decreased viability after Maraba virus infection GR00252-A-2 9.23 BCL11B TAF12 TCL1B
8 Decreased viability after Maraba virus infection GR00252-A-3 9.23 BCL11B TAF12 TCL1B

Drugs & Therapeutics for Splenic Manifestation of Leukemia

Search Clinical Trials , NIH Clinical Center for Splenic Manifestation of Leukemia

Genetic Tests for Splenic Manifestation of Leukemia

Anatomical Context for Splenic Manifestation of Leukemia

The Foundational Model of Anatomy Ontology organs/tissues related to Splenic Manifestation of Leukemia:

19
Spleen

MalaCards organs/tissues related to Splenic Manifestation of Leukemia:

40
Spleen, Thymus, Ovary

Publications for Splenic Manifestation of Leukemia

Articles related to Splenic Manifestation of Leukemia:

# Title Authors PMID Year
1
Phenotypic heterogeneity of leukemias associated with Friend MuLV infection: studies on T-cell lymphomas and null cell leukemias in euthymic and thymus-deficient mice. 61
6332242 1984
2
[Acquired hemolytic anemia with symptoms of a pure splenic leukemia]. 61
13442249 1957

Variations for Splenic Manifestation of Leukemia

Expression for Splenic Manifestation of Leukemia

Search GEO for disease gene expression data for Splenic Manifestation of Leukemia.

Pathways for Splenic Manifestation of Leukemia

GO Terms for Splenic Manifestation of Leukemia

Cellular components related to Splenic Manifestation of Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor TFIID complex GO:0005669 8.96 TAF7 TAF12
2 transcription factor TFTC complex GO:0033276 8.62 TAF7 TAF12

Biological processes related to Splenic Manifestation of Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signal transduction by p53 class mediator GO:1901796 9.32 TAF7 TAF12
2 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.26 TCL1B TCL1A
3 positive regulation of protein serine/threonine kinase activity GO:0071902 9.16 TCL1B TCL1A
4 DNA-templated transcription, initiation GO:0006352 8.96 TAF7 TAF12
5 RNA polymerase II preinitiation complex assembly GO:0051123 8.62 TAF7 TAF12

Molecular functions related to Splenic Manifestation of Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II general transcription initiation factor activity GO:0016251 8.96 TAF7 TAF12
2 protein serine/threonine kinase activator activity GO:0043539 8.62 TCL1B TCL1A

Sources for Splenic Manifestation of Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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