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SMZL
MCID: SPL004
MIFTS: 50

Splenic Marginal Zone Lymphoma (SMZL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Splenic Marginal Zone Lymphoma

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MalaCards integrated aliases for Splenic Marginal Zone Lymphoma:

Name: Splenic Marginal Zone Lymphoma 12 58 15 37 17
Splenic Marginal Zone B-Cell Lymphoma 70
Smzl 58

Characteristics:

Orphanet epidemiological data:

58
splenic marginal zone lymphoma
Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:0050750
ICD10 via Orphanet 33 C83.0
UMLS via Orphanet 71 C0349632
Orphanet 58 ORPHA86854
UMLS 70 C0349632
Sources

Summaries for Splenic Marginal Zone Lymphoma

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Disease Ontology : 12 A marginal zone B-cell lymphocyte located in the spleen comprised of B-cells in place of white pulp.

MalaCards based summary : Splenic Marginal Zone Lymphoma, also known as splenic marginal zone b-cell lymphoma, is related to marginal zone b-cell lymphoma and lymphoma, hodgkin, classic. An important gene associated with Splenic Marginal Zone Lymphoma is NOTCH2 (Notch Receptor 2), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Pathways in cancer. The drugs Thiotepa and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include spleen comprised of b-cells in place of white pulp, bone marrow and bone, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Splenic marginal zone lymphoma (SMZL) is a type of cancer (specifically a lymphoma) made up of B-cells... more...

Sources

Related Diseases for Splenic Marginal Zone Lymphoma

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Diseases related to Splenic Marginal Zone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 marginal zone b-cell lymphoma 31.6 SDC1 PAX5 MALT1 FOXP1 CD5 BTK
2 lymphoma, hodgkin, classic 31.3 TRAF3 PAX5 CD40 BCL6
3 lymphoma 31.2 PAX5 NFKB2 MALT1 CDK6 CD5 BIRC3
4 nodal marginal zone b-cell lymphoma 31.2 MALT1 BCL6
5 b-cell non-hodgkin lymphoma 31.2 NFKB2 BCL6
6 nodal marginal zone lymphoma 31.1 NOTCH2 CD5 BCL6
7 composite lymphoma 30.8 PAX5 CD5 BCL6
8 lymphoplasmacytic lymphoma 30.7 SDC1 PAX5 CD5 BTK BCL6
9 follicular lymphoma 30.7 SYK CD5 CD40 BCL6 AICDA
10 macroglobulinemia 30.7 SYK SDC1 PAX5 CD40 BTK
11 splenic disease 30.6 ITGAE CD5 BCL6
12 cll/sll 30.4 PAX5 CD5 BTK BCL6
13 agammaglobulinemia 30.3 SYK CD40 BTK
14 mantle cell lymphoma 30.1 SYK PAX5 MALT1 CDK6 CD5 CD40
15 burkitt lymphoma 30.1 PAX5 CD40 BIRC3 BCL6 AICDA
16 waldenstroem's macroglobulinemia 30.1 TRAF3 SDC1 PAX5 CD5 CD40 BTK
17 mature b-cell neoplasm 29.9 SDC1 PAX5 CD5 CD40 BCL6 AICDA
18 b-cell lymphoma 29.9 SYK PAX5 NFKB2 MALT1 FOXP1 CDK6
19 leukemia, chronic lymphocytic 29.8 SYK SDC1 PAX5 ITGAE CD5 CD40
20 lymphoma, non-hodgkin, familial 29.8 SYK SDC1 PAX5 MALT1 CDK6 CD5
21 lymphoma, mucosa-associated lymphoid type 29.8 SDC1 PAX5 MALT1 FOXP1 CD5 CD40
22 immune deficiency disease 29.7 SYK CD5 CD40 BTK BCL6 AICDA
23 myeloma, multiple 29.7 TRAF3 SDC1 CREBBP CD5 CD40 BTK
24 diffuse large b-cell lymphoma 29.5 SYK SDC1 PAX5 MALT1 FOXP1 CREBBP
25 splenomegaly 10.9
26 hemolytic anemia 10.6
27 anemia, autoimmune hemolytic 10.6
28 lymphoproliferative syndrome 10.6
29 hepatitis c virus 10.6
30 deficiency anemia 10.5
31 hepatitis c 10.5
32 hepatitis b 10.5
33 hepatitis 10.5
34 hairy cell leukemia 10.5
35 indolent b cell lymphoma 10.5
36 neutropenia 10.5
37 pancytopenia 10.5
38 thrombocytopenia 10.5
39 bladder lymphoma 10.4 CD5 BCL6
40 angioedema 10.4
41 hypersplenism 10.4
42 acquired angioedema 10.4
43 chromosomal triplication 10.4
44 ureteral lymphoma 10.4 CD5 BCL6
45 paranasal sinus lymphoma 10.4 PAX5 BCL6
46 prostate lymphoma 10.4 CD5 BCL6
47 epiglottis neoplasm 10.4 CD5 BCL6
48 bone lymphoma 10.4 CD5 BCL6
49 colon lymphoma 10.3 CD5 BCL6
50 appendix lymphoma 10.3 CD5 BCL6

Graphical network of the top 20 diseases related to Splenic Marginal Zone Lymphoma:



Diseases related to Splenic Marginal Zone Lymphoma
Sources

Symptoms & Phenotypes for Splenic Marginal Zone Lymphoma

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MGI Mouse Phenotypes related to Splenic Marginal Zone Lymphoma:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.39 AICDA BCL6 BIRC3 BTK CD40 CD5
2 immune system MP:0005387 10.33 AICDA BCL6 BIRC3 BTK CD40 CD5
3 cellular MP:0005384 10.29 AICDA BCL6 BIRC3 BTK CDK6 CREBBP
4 growth/size/body region MP:0005378 10.29 BCL6 BTK CD5 CDK6 CREBBP ITGAE
5 homeostasis/metabolism MP:0005376 10.25 AICDA BCL6 BIRC3 BTK CD40 CREBBP
6 endocrine/exocrine gland MP:0005379 10.15 BCL6 CD40 CDK6 CREBBP NFKB2 NOTCH2
7 mortality/aging MP:0010768 10.13 AICDA AMOTL1 BCL6 BIRC3 BTK CDK6
8 integument MP:0010771 10.02 AICDA BCL6 BTK CD5 CREBBP MALT1
9 liver/biliary system MP:0005370 9.92 BCL6 CDK6 CREBBP KLF2 NFKB2 NOTCH2
10 neoplasm MP:0002006 9.7 AICDA BTK CDK6 CREBBP NOTCH2 PAX5
11 no phenotypic analysis MP:0003012 9.5 AICDA BCL6 CD5 KLF2 NOTCH2 SYK
12 normal MP:0002873 9.32 AICDA AMOTL1 BCL6 BIRC3 CD40 CD5
Sources

Drugs & Therapeutics for Splenic Marginal Zone Lymphoma

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Drugs for Splenic Marginal Zone Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 296)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiotepa Approved, Investigational Phase 4 52-24-4 5453
2
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
3
Idarubicin Approved Phase 3 58957-92-9 42890
4 Orange Approved Phase 3
5
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
6
Ondansetron Approved Phase 3 99614-02-5 4595
7
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
8
Morphine Approved, Investigational Phase 3 57-27-2 5288826
9
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 3 14838-15-4 26934
10
Chlorambucil Approved Phase 3 305-03-3 2708
11
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
12
Darbepoetin alfa Approved, Investigational Phase 3 209810-58-2, 11096-26-7
13
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
14
Palivizumab Approved, Investigational Phase 3 188039-54-5
15
Ribavirin Approved Phase 3 36791-04-5 37542
16
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
17
Captopril Approved Phase 3 62571-86-2 44093
18
Acyclovir Approved Phase 3 59277-89-3 2022
19
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
20
Ofloxacin Approved Phase 3 82419-36-1 4583
21
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
22
Carboplatin Approved Phase 2, Phase 3 41575-94-4 10339178 498142 38904
23
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
24
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 468682 2826718
25
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
26
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
27
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
28
Dalteparin Approved Phase 3 9005-49-6
29
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
30
Tazobactam Approved Phase 3 89786-04-9 123630
31
Vancomycin Approved Phase 3 1404-90-6 441141 14969
32
Piperacillin Approved Phase 3 66258-76-2 43672
33
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
34
Mycophenolic acid Approved Phase 3 24280-93-1 446541
35
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
36
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
37
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
38
Polyestradiol phosphate Approved Phase 3 28014-46-2
39
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
40
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
41
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
42
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
43
Ginseng Approved, Investigational, Nutraceutical Phase 3 50647-08-0
44
St. John's Wort Approved, Investigational, Nutraceutical Phase 3 84082-80-4
45
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
46
Epratuzumab Investigational Phase 2, Phase 3 205923-57-5
47 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
48 Ferric Oxide, Saccharated Phase 3
49 Dextrans Phase 3
50 Plasma Substitutes Phase 3

Interventional clinical trials:

(show top 50) (show all 361)
# Name Status NCT ID Phase Drugs
1 Evaluation of Allogeneic Marrow Transplants Depleted of T-Cells by CD34+ Selection in Patients Undergoing Transplantation With an Unrelated Matched or 1 Antigen Mismatched Donor or a 1 Antigen Mismatched Related Donor Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
2 Randomized Controlled Study of Iron Supplementation to Support the Response to Recombinant Human Erythropoietin for the Treatment of Chemotherapy-Induced Anaemia Unknown status NCT00482716 Phase 3
3 A Randomized Double-Blind Controlled Trial of Ketamine Versus Placebo in Conjunction With Best Pain Management in Neuropathic Pain in Cancer Patients Unknown status NCT01316744 Phase 3 ketamine hydrochloride
4 Randomised Controlled Trial of CID (Chlorambucil, Idarubicin, Dexamethasone) Versus CD (Chlorambucil, Dexamethasone) for Induction of Remission in Low Grade Non-Hodgkin's Lymphoma (Kiel Classification) Followed by Randomised Controlled Assessment of Standard Dose Interferon Versus Low Dose Interferon Versus No Further Therapy as Maintenance Treatment After Remission Induction Unknown status NCT00003639 Phase 3 chlorambucil;dexamethasone;idarubicin
5 A Randomized Phase III Study to Assess Intensification of the Conditioning Regimen for Allogenic Stem Cell Transplantation (ALLO-SCT) for Leukemia or Myelodysplastic Syndrome With a High Risk of Relapse Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
6 A Prospective Randomised Phase III Trial of Early Hospital Discharge Versus Standard Inpatient Management of Cancer Patients With Low-Risk Febrile Neutropenia Receiving Oral Antibiotics. Oral Antibiotics for Neutropenic Sepsis Giving Early Hospital Discharge [ORANGE] Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
7 Multicenter, Double-Blind, Randomized Study to Compare the Safety and Efficacy of Levofloxacin With That of Cefepime in the Treatment of Fever and Neutropenia - Phase IIIB Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
8 The Utility of LymphoScan Imaging in the Dectection of Residual Tumor After Chemotherapy and/or Radiotherapy in Patients With Non-Hodgkin's Lymphoma Unknown status NCT00003338 Phase 2, Phase 3
9 The Utility of LymphoScan Imaging in the Localization and Staging of Patients With Non-Hodgkin's Lymphoma Unknown status NCT00003337 Phase 3
10 A European Randomized Multicenter Study of Interferon Alfa-2b Versus No Treatment After Intensive Therapy and Autologous Hematopoietic Stem Cell Transplantation for Relapsing Lymphoma Patients (Non-Hodgkin Lymphomas and Hodgkin's Disease) Unknown status NCT00003924 Phase 3
11 Randomised Study Comparing 6 And 8 Cycles Of Chemotherapy With CHOP ( Cyclophosphamide, Doxorubicin, Vincristine And Prednisone) At 14-Day Intervals (CHOP-14), Both With Or Without The Monoclonal Anti-CD20 Antibody Rituximab In Patients Aged 61 To 80 Years With Aggressive Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
12 Preparatory Aid to Improve Decision Making About Cancer Clinical Trials (PRE-ACT) Completed NCT00750009 Phase 3
13 Phase III Randomized Trial of an Opioid Titration Order Sheet Compared to Standard of Care in Patients With Cancer Related Pain. Completed NCT00666211 Phase 3
14 A Randomised Trial of Chlorambucil Versus Fludarabine as Initial Therapy of Waldenström's Macroglobulinaemia and Splenic Lymphoma With Villous Lymphocytes Completed NCT00608374 Phase 3 chlorambucil;fludarabine phosphate
15 The Use of American Ginseng (Panax Quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind, Placebo-Controlled Phase III Study Completed NCT00719563 Phase 3 American ginseng
16 Randomized Placebo Controlled Double Blind Study of Restasis Versus Placebo in Primary Prevention of Ocular GVHD After Allogeneic Stem Cell Transplantation Completed NCT00755040 Phase 3 cyclosporine ophthalmic emulsion
17 A Phase III, Randomized Study of the Effects of Parenteral Iron, Oral Iron, or No Iron Supplementation on the Erythropoietic Response to Darbepoetin Alfa for Cancer Patients With Chemotherapy-Associated Anemia Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
18 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
19 Phase III Trial of T Lymphocyte Depletion by Elutriation and CD34 Add-Back for Allogeneic Bone Marrow Transplantation Completed NCT00265837 Phase 3
20 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
21 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
22 The Effects of Procrit (Epoetin Alfa) on Hemoglobin Symptom Distress and Quality of Life During Chemotherapy in Lymphoma Patients With Mild to Moderate Anemia A Multicenter Trial Completed NCT00003341 Phase 3
23 Allogeneic Blood or Marrow Transplantation for Hematologic Malignancy and Aplastic Anemia Completed NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
24 A Phase III Randomized Trial of CHOP Chemotherapy Plus Rituxan (IDEC-C2B8) Versus CHOP Chemotherapy Alone for Newly Diagnosed, Previously Untreated, Aggressive Non-Hodgkin's Lymphoma Completed NCT00004112 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
25 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
26 Randomized Trial of Autologous GVHD for Refractory Lymphoma Completed NCT00003414 Phase 3 busulfan;cyclophosphamide;cyclosporine
27 A Double-Blind Study Of Nutritional Intervention For The Treatment Of Cancer Cachexia Using Juven® Nutritional Supplement Completed NCT00053053 Phase 3
28 A Phase III Multicenter Study of Cytomegalovirus Prophylaxis With Valacyclovir for the Prevention of Serious Fungal and Bacterial Infections Among Cytomegalovirus Seronegative Recipients of Cytomegalovirus Seropositive Sx Stem Cell Transplants Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
29 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
30 Does Hypericum Reduce Fatigue in Cancer Patients on Chemotherapy? A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Completed NCT00005805 Phase 3
31 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
32 A Phase III Double-Blind Equivalence Study of Two Different Formulations of Slow-Release Morphine Followed by a Randomization Between Dextromethorphan or Placebo Plus Statex SR for Chronic Cancer Pain Relief in Terminally Ill Patients Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
33 A Randomized Multicentre Study Comparing G-CSF Mobilized Peripheral Blood and G-CSF Stimulated Bone Marrow in Patients Undergoing Matched Sibling Transplantation for Hematologic Malignancies Completed NCT00438958 Phase 3
34 Music Video and Adolescent/Young Adult Resilience During Transplant Completed NCT00305851 Phase 3
35 Phase III, Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Ondansetron in the Control of Chronic Nausea and Vomiting Not Due to Antineoplastic Therapy in Patients With Advanced Cancer Completed NCT00006348 Phase 3 ondansetron
36 A Phase III Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Fragmin (5,000 IU Subcutaneously) in Preventing Catheter-Related Complications When Given Daily to Cancer Patients With Central Venous Catheters Completed NCT00006083 Phase 3 Fragmin
37 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
38 Vancomycin Versus Placebo in Persistently Febrile Granulocytopenic Patients Given Piperacillin/Tazobactam Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
39 Randomized Trial Comparing the Efficacy of Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia,Lymphoplasmacytic Lymphoma or Splenic Marginal Zone Lymphoma Completed NCT00566332 Phase 3 Chlorambucil;Fludarabine
40 Randomized Phase III Trial Comparing Two Different Rituximab Dosing Regimens For Patients With Low Tumor Burden Indolent Non-Hodgkin's Lymphoma Active, not recruiting NCT00075946 Phase 3
41 A Randomized Study to Evaluate The Efficacy of Mycophenolate Mofetil Added to The Systemic Immunosuppressive Regimen First Used For Treatment of Chronic Graft-Versus-Host Disease Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
42 Peripheral Blood Stem Cell Transplantation in Patients With Advanced Malignancies Eligible for Allogeneic Transplantation From Matched Related Donors: A Randomized Study of Cyclosporine/Methotrexate or Cyclosporine/T-Cell Depletion (CD34 Cell Selection) for GVHD Prophylaxis Terminated NCT00003056 Phase 3 cyclosporine;cyclosporine and methotrexate
43 Randomized, Double Blinded, Placebo-Controlled Trial of Antibacterial Prophylaxis for the Prevention of Bacterial Infections in the Post-Engraftment Phase After Allogeneic Hematopoeitic Stem Cell Transplantation Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
44 A Randomized Phase III Trial Comparing the Combination of Fludarabine, BBR 2778 (Pixantrone) and Rituximab (FP-R) With the Combination of Fludarabine and Rituximab (F-R) in the Treatment of Patients With Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma Withdrawn NCT00551239 Phase 3 fludarabine phosphate;pixantrone dimaleate
45 Allograft of Hematopoietic Stem Cells With Reduced-intensity Conditioning From a HLA-haploidentical Family Donor: Phase II Study of Combined Immunosuppression Before and After Transplantation Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
46 Safety and Efficacy of Sequential Treatment With a Combination of Rituximab, Fludarabine and Cyclophosphamide Followed by Zevalin (Rituximab and Y-Ibritumomab Tiuxetan) - A Phase I/II Study for Treatment of Patients With Relapsed Indolent and Transformed CD20-Positive B-Cell Non-Hodgkin's-Lymphoma Ineligible for High-Dose Chemo(Radio)Therapy Supported by Autologous Peripheral Blood Stem-Cells Unknown status NCT00397800 Phase 1, Phase 2 cyclophosphamide;fludarabine phosphate
47 Non-Ablative Chemotherapeutic Conditioning Before Allogeneic Stem Cell Transplantation Unknown status NCT00008307 Phase 2 cyclosporine;fludarabine phosphate;melphalan;methylprednisolone;mycophenolate mofetil
48 Phase I/II Study to Assess the Safety and Efficacy of Low Doses of Beta LT in Patients With B-Cell Lymphoma Unknown status NCT00007839 Phase 1, Phase 2 beta alethine
49 Phase II Study of Arsenic Trioxide in Relapsed/Refractory Acute Leukemia and Blast Crisis of Chronic Myeloid Leukemia Unknown status NCT00003885 Phase 2 arsenic trioxide
50 Transplantation Using Umbilical Cord And Placental Blood Unknown status NCT00008164 Phase 2

Search NIH Clinical Center for Splenic Marginal Zone Lymphoma

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Splenic Marginal Zone Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Splenic Marginal Zone Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Splenic Marginal Zone Lymphoma:
Bone marrow-derived hematopoietic stem cells
Sources

Genetic Tests for Splenic Marginal Zone Lymphoma

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Sources

Anatomical Context for Splenic Marginal Zone Lymphoma

About this section

The Foundational Model of Anatomy Ontology organs/tissues related to Splenic Marginal Zone Lymphoma:

19
Spleen Comprised Of B-Cells In Place Of White Pulp

MalaCards organs/tissues related to Splenic Marginal Zone Lymphoma:

40
Bone Marrow, Bone, Spleen, B Cells, T Cells, Liver, Thyroid
Sources

Publications for Splenic Marginal Zone Lymphoma

About this section

Articles related to Splenic Marginal Zone Lymphoma:

(show top 50) (show all 552)
# Title Authors PMID Year
1
VS38 staining contributes to a novel gating strategy in flow cytometry for small B cell lymphoma, especially in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. 61
33682304 2021
2
Peripheral blood morphology review and diagnostic proficiency evaluation by a new Spanish EQAS during the period 2011-2019. 61
32870604 2021
3
A deep molecular response of splenic marginal zone lymphoma to front-line checkpoint blockade. 61
33054119 2021
4
The Journey of Primary Myelofibrosis to Splenic Marginal Zone Lymphoma on the Wheels of Ruxolitinib. 61
33707858 2021
5
Radiologically-guided percutaneous core needle biopsy of the spleen: a reliable and safe diagnostic procedure for neoplastic and reactive conditions. 61
33393079 2021
6
Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors. 61
33570635 2021
7
RNA sequencing analyses reveal differentially expressed genes and pathways as Notch2 targets in B-cell lymphoma. 61
33400727 2020
8
Frequency of MYD88 L256P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasm. 61
33217360 2020
9
Splenic marginal zone lymphoma: A US population-based survival analysis (1999-2016). 61
32767702 2020
10
Prognostic Value of 18F-FDG PET/CT Metabolic Parameters in Splenic Marginal Zone Lymphoma. 61
32703751 2020
11
Rituximab-induced acute thrombocytopenia in patients with splenomegaly B Cell lymphoma: an underdiagnosed but severe complication. 61
33121338 2020
12
Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. 61
33017398 2020
13
Splenic marginal zone lymphoma: a case report and literature review. 61
33004051 2020
14
Rituximab Monotherapy or in Combination with Bendamustine Is Not Inferior to Rituximab-CHOP Regimen in the Treatment of Patients with Splenic Marginal Zone Lymphoma in the Real Life. 61
32892194 2020
15
The Diagnostic Utility of Splenectomy in Idiopathic Splenomegaly. 61
32394013 2020
16
Atypical course of infective endocarditis in a patient with complex congenital heart disease, chronic hepatitis B virus infection, and splenic marginal zone lymphoma. 61
32426956 2020
17
Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy: A case report. 61
32871937 2020
18
Risk adapted approach: How to treat splenic marginal zone lymphoma in resource-poor settings? - The real-life experience of a Brazilian cancer treatment center. 61
32746790 2020
19
Guillain-Barre Syndrome and Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Secretion as Paraneoplastic Syndromes in Splenic Marginal B-cell Non-Hodgkins Lymphoma: A Rare Presentation. 61
32879838 2020
20
Successful rechallenge of rituximab following severe rituximab-induced acute thrombocytopenia in a patient with splenic marginal zone lymphoma. 61
31766968 2020
21
BRAF V600E mutation detection in hairy cell leukemia-utility of archival DNA from bone marrow aspirate/imprint smear and amplification refractory mutation system. 61
32458259 2020
22
Immunohistochemistry contribution in the diagnosis of splenic marginal zone lymphoma. 61
32638957 2020
23
Splenic Marginal Zone Lymphoma in Turkey: Association with Hepatitis B Instead of Hepatitis C Virus as an Etiologic and Possible Prognostic Factor - A Multicenter Cohort Study 61
31630512 2020
24
Molecular characterization of sorted malignant B cells from patients clinically identified with mantle cell lymphoma. 61
32173361 2020
25
Acquired C1-inhibitor deficiency due to splenic marginal zone lymhoma: Case Report. 61
32228367 2020
26
Cerebral HSV-1 Vasculitis as a Fatal Complication of Immunosuppression in Non-Hodgkin´s Lymphoma: A Case Report and Review of the Literature. 61
32151046 2020
27
Proposed rituximab biosimilar BCD-020 versus reference rituximab for treatment of patients with indolent non-Hodgkin lymphomas: An international multicenter randomized trial. 61
31724191 2020
28
Identification of a Splenic Marginal Zone Lymphoma Signature: Preliminary Findings With Diagnostic Potential. 61
32457837 2020
29
Acquired Angioedema due to C1 Inhibitor Deficiency Preceding Splenic Marginal Zone Lymphoma: Further Insights from Clinical Practice. 61
32894844 2020
30
Successful Surgical Removal of the Largest Known Spleen. 61
32158587 2020
31
Rare Causes of Isolated and Progressive Splenic Lesions: Challenges in Differential Diagnosis, Evaluation, and Treatment of Primary Splenic Lymphomas. 61
32565679 2020
32
Contemporary management of nodal and primary splenic marginal zone lymphoma. 61
31619091 2019
33
Splenectomy in Lymphoproliferative Disorders: A Single Eastern European Center Experience. 61
31892196 2019
34
Deregulated NKL Homeobox Genes in B-Cell Lymphoma. 61
31779217 2019
35
JSH practical guidelines for hematological malignancies, 2018: II. Lymphoma-2. Marginal zone lymphoma (MALT lymphoma/extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and splenic marginal zone lymphoma). 61
31428970 2019
36
A Case of Acquired Angioedema with Low C1 Inhibitor (C1-INH) Associated with Splenic Marginal Zone Lymphoma. 61
31588119 2019
37
A Case of Rituximab-Induced Acute Thrombocytopenia in a Patient with Splenic Marginal Zone Lymphoma and Chronic Hepatitis C Virus Infection. 61
31541071 2019
38
Splenic Marginal Zone Lymphoma with Prominent Myelofibrosis Mimicking Triple-Negative Primary Myelofibrosis. 61
31762757 2019
39
Practical Applications in Immunohistochemistry: An Immunophenotypic Approach to the Spleen. 61
30917045 2019
40
Splenic marginal zone lymphoma associated with hepatitis B virus infection, remission after viral treatment, and splenectomy: A case report and review of the literature. 61
31306619 2019
41
Epidermotropic CXCR3 positive marginal zone lymphoma: a distinctive clinical histopathological entity potentially originating in the skin; it does not always indicate splenic marginal zone lymphoma. 61
31450275 2019
42
Systematic Review of Somatic Mutations in Splenic Marginal Zone Lymphoma. 61
31320741 2019
43
Transformation of a splenic marginal zone lymphoma into classic Hodgkin lymphoma. 61
30814198 2019
44
Splenic Marginal Zone B-Cell Lymphoma With Splenic Infarction in a Patient With Cold Agglutinin Disease. 61
30888998 2019
45
Central nervous system involvement in primary bone marrow or splenic marginal zone lymphoma: Report of two cases and review of the literature. 61
30592785 2019
46
Lymphomagenic properties of a HIV p17 variant derived from a splenic marginal zone lymphoma occurred in a HIV-infected patient. 61
30261551 2019
47
Bone marrow-derived mesenchymal stem/stromal cells from patients with splenic marginal zone lymphoma are intrinsically impaired and influence the malignant B-cells. 61
29966468 2019
48
Splenic marginal zone lymphoma leads to sinistral portal hypertension. 61
30549195 2019
49
Splenic marginal zone lymphoma treated with laparoscopic splenectomy: A case report. 61
31759300 2019
50
Stereotyped B Cell Receptor Immunoglobulins in B Cell Lymphomas. 61
30779034 2019
Sources

Variations for Splenic Marginal Zone Lymphoma

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Copy number variations for Splenic Marginal Zone Lymphoma from CNVD:

7 (show top 50) (show all 56)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 31168 1 25800000 154800000 Duplication Splenic marginal zone lymphoma
2 38774 10 104900000 119100000 Deletion Splenic marginal zone lymphoma
3 56497 11 59700000 61400000 Duplication Splenic marginal zone lymphoma
4 69123 12 53100000 55200000 Gain GLI1 Splenic marginal zone lymphoma
5 78495 13 52200000 109100000 Gain Splenic marginal zone lymphoma
6 86225 14 55800000 78400000 Loss Splenic marginal zone lymphoma
7 91971 15 37900000 47600000 Deletion Splenic marginal zone lymphoma
8 97450 16 10300000 16700000 Gain Splenic marginal zone lymphoma
9 106744 17 1 11200000 Deletion Splenic marginal zone lymphoma
10 106745 17 1 11200000 Deletion Splenic marginal zone lymphoma
11 108750 17 22200000 78774742 Duplication Splenic marginal zone lymphoma
12 119209 18 1 76117153 Duplication Splenic marginal zone lymphoma
13 120285 18 23300000 31000000 Deletion Splenic marginal zone lymphoma
14 134527 2 102400000 159600000 Deletion Splenic marginal zone lymphoma
15 155734 20 57900000 62435964 Duplication Splenic marginal zone lymphoma
16 160287 22 11800000 49691432 Duplication Splenic marginal zone lymphoma
17 166594 3 104400000 107800000 Deletion Splenic marginal zone lymphoma
18 173065 3 189400000 193800000 Duplication Splenic marginal zone lymphoma
19 177287 3 5500000 8700000 Deletion Splenic marginal zone lymphoma
20 178512 3 74200000 83700000 Duplication Splenic marginal zone lymphoma
21 181981 4 131300000 151000000 Deletion Splenic marginal zone lymphoma
22 190152 4 84000000 161500000 Deletion Splenic marginal zone lymphoma
23 190418 4 88200000 94000000 Duplication Splenic marginal zone lymphoma
24 201328 5 68400000 73300000 Duplication Splenic marginal zone lymphoma
25 207408 6 155600000 160900000 Duplication Splenic marginal zone lymphoma
26 209385 6 26100000 45200000 Duplication Splenic marginal zone lymphoma
27 212692 6 40600000 45200000 Duplication Splenic marginal zone lymphoma
28 217433 7 101175494 101390682 Deletion CUX1 Splenic marginal zone lymphoma
29 217434 12 109956211 110272739 Deletion CUX2 Splenic marginal zone lymphoma
30 217435 7 101175494 101390682 Deletion MUC12 Splenic marginal zone lymphoma
31 217436 7 101175494 101390682 Deletion MUC3A Splenic marginal zone lymphoma
32 218058 7 107200000 147500000 Deletion Splenic marginal zone lymphoma
33 219020 7 120900000 123600000 Loss POT1 Splenic marginal zone lymphoma
34 219788 7 130078078 130270796 Deletion AGK Splenic marginal zone lymphoma
35 219789 7 130078078 130270796 Deletion BPGM Splenic marginal zone lymphoma
36 219790 7 130078078 130270796 Deletion CALD1 Splenic marginal zone lymphoma
37 219791 7 130078078 130270796 Deletion CNTNAP2 Splenic marginal zone lymphoma
38 219792 7 130078078 130270796 Deletion FOXP2 Splenic marginal zone lymphoma
39 219793 7 130078078 130270796 Deletion GRM8 Splenic marginal zone lymphoma
40 219794 7 130078078 130270796 Deletion IMMP2L Splenic marginal zone lymphoma
41 219795 7 130078078 130270796 Deletion KEL Splenic marginal zone lymphoma
42 219796 7 130078078 130270796 Deletion MET Splenic marginal zone lymphoma
43 219797 7 130078078 130270796 Deletion Splenic marginal zone lymphoma
44 219798 7 130078078 130270796 Deletion PTN Splenic marginal zone lymphoma
45 219799 7 130078078 130270796 Deletion PTPRZ1 Splenic marginal zone lymphoma
46 219800 7 130078078 130270796 Deletion ST7 Splenic marginal zone lymphoma
47 219801 7 130078078 130270796 Deletion SVOPL Splenic marginal zone lymphoma
48 219802 7 130078078 130270796 Deletion TES Splenic marginal zone lymphoma
49 219803 7 130078078 130270796 Deletion THAP5 Splenic marginal zone lymphoma
50 219804 7 130078078 130270796 Deletion TPK1 Splenic marginal zone lymphoma
Sources

Expression for Splenic Marginal Zone Lymphoma

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Search GEO for disease gene expression data for Splenic Marginal Zone Lymphoma.
Sources

Pathways for Splenic Marginal Zone Lymphoma

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Pathways related to Splenic Marginal Zone Lymphoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.08 TRAF3 SYK NFKB2 CREBBP CDK6 CD40
2
Pathways in cancer 36
12.7 TRAF3 NOTCH2 NFKB2 CREBBP CDK6 BIRC3
3
IL-2 Pathway 63
Show member pathways
 12.68 SYK MALT1 CREBBP CD40 BTK
4
NF-KappaB Family Pathway 63
Show member pathways
 12.59 TRAF3 NFKB2 MALT1 CREBBP CD40
5
RANK Signaling in Osteoclasts 63
Show member pathways
 12.53 TRAF3 SYK NFKB2 BTK BIRC3
6
Measles 36
Show member pathways
 12.51 TRAF3 SYK NFKB2 CREBBP CDK6 CD40
7
Immune response NFAT in immune response 23
Show member pathways
 12.5 SYK NFKB2 MALT1 CD40 BTK
8
Notch Signaling Pathway (WikiPathways) 36
Show member pathways
 12.44 NOTCH2 NFKB2 CREBBP BCL6
9
MicroRNAs in cancer 36
12.4 NOTCH2 MIR26B FOXP1 CREBBP CDK6
10
CLEC7A (Dectin-1) signaling 65
Show member pathways
 12.31 SYK NFKB2 MALT1 CREBBP
11
B cell receptor signaling pathway (KEGG) 36
Show member pathways
 12.28 SYK MALT1 BTK BCL6
12
Viral carcinogenesis 36
12.16 TRAF3 SYK NFKB2 CREBBP CDK6
13
Transcriptional misregulation in cancer 36
12.15 PAX5 CD40 BIRC3 BCL6
14
NF-kappaB Signaling 4
12.07 TRAF3 SYK PAX5 NFKB2 MALT1 BTK
15
B Cell Receptor Signaling Pathway (sino) 66
Show member pathways
 12.06 SYK NFKB2 MALT1 CD40 BTK BCL6
16
C-type lectin receptor signaling pathway 36
Show member pathways
 11.96 SYK NFKB2 MALT1 CREBBP BTK
17
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.86 SDC1 NOTCH2 CD5
18
Small cell lung cancer 36
11.75 TRAF3 CDK6 BIRC3
19
LT-BetaR Pathway 63
Show member pathways
 11.69 TRAF3 NFKB2 CREBBP
20
C-MYB transcription factor network 1
11.63 PAX5 CREBBP CDK6 BIRC3
21
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 23
Show member pathways
 11.57 TRAF3 NFKB2 CD40 BIRC3
22
IgA-Producing B Cells in the Intestine 64
11.49 PAX5 ITGAE CD40 BCL6
23
Primary immunodeficiency 36
11.28 CD40 BTK AICDA
24
NF-kappa B signaling pathway 36
11.18 TRAF3 SYK NFKB2 MALT1 CD40 BTK
25
CD40/CD40L signaling 1
11.13 TRAF3 CD40 BIRC3
Sources

GO Terms for Splenic Marginal Zone Lymphoma

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Cellular components related to Splenic Marginal Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CD40 receptor complex GO:0035631 8.62 TRAF3 CD40

Biological processes related to Splenic Marginal Zone Lymphoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.93 PAX5 NOTCH2 KLF2 FOXP1 CREBBP BCL6
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.7 SYK MALT1 CREBBP
3 regulation of inflammatory response GO:0050727 9.69 FOXP1 BIRC3 BCL6
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.62 NFKB2 MALT1 CD40 BTK
5 positive regulation of type I interferon production GO:0032481 9.54 SYK NFKB2 CREBBP
6 positive regulation of B cell differentiation GO:0045579 9.49 SYK BTK
7 lateral ventricle development GO:0021670 9.48 PAX5 CDK6
8 negative regulation of B cell apoptotic process GO:0002903 9.43 FOXP1 BCL6
9 germinal center formation GO:0002467 9.4 NFKB2 BCL6
10 B cell activation GO:0042113 9.33 MALT1 CD40 BTK
11 cellular response to molecule of fungal origin GO:0071226 9.26 SYK BTK
12 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.13 TRAF3 CD40 BIRC3
13 regulation of apoptotic process GO:0042981 9.02 TRAF3 MALT1 CREBBP BIRC3 BCL6

Molecular functions related to Splenic Marginal Zone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.23 TRAF3 SDC1 MALT1 FOXP1 BTK BCL6
Sources

Sources for Splenic Marginal Zone Lymphoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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