MCID: SPL009
MIFTS: 26

Splenic Sequestration

Categories: Immune diseases

Aliases & Classifications for Splenic Sequestration

MalaCards integrated aliases for Splenic Sequestration:

Name: Splenic Sequestration 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11786
ICD9CM 35 289.52
UMLS 73 C1260402

Summaries for Splenic Sequestration

MalaCards based summary : Splenic Sequestration is related to sickle cell disease and sickle cell anemia. An important gene associated with Splenic Sequestration is THPO (Thrombopoietin). The drugs Desogestrel and Etonogestrel have been mentioned in the context of this disorder. Affiliated tissues include spleen.

Related Diseases for Splenic Sequestration

Diseases related to Splenic Sequestration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 sickle cell disease 30.2 BCAM HBB
2 sickle cell anemia 10.2
3 thalassemia 10.1
4 beta-thalassemia 10.1
5 splenic disease 10.0 HBB THPO
6 hemoglobin c disease 10.0
7 thrombocytopenia 10.0
8 hereditary spherocytosis 10.0
9 splenic infarction 10.0
10 sickle beta thalassemia 10.0
11 aging 9.9
12 hepatitis 9.9
13 leukemia 9.9
14 hypersplenism 9.9
15 splenomegaly 9.9
16 anemia, sideroblastic, 1 9.9 ALAD HBB
17 immune system disease 9.8 HBB THPO
18 leukemia, chronic lymphocytic 2 9.7
19 leukemia, chronic lymphocytic 9.7
20 hemolytic anemia 9.7
21 schistosomiasis 9.7
22 acute chest syndrome 9.7
23 gaucher's disease 9.7
24 hemoglobinopathy 9.7
25 peritonitis 9.7
26 leukemia, b-cell, chronic 9.7
27 hemoglobin e-beta-thalassemia syndrome 9.7
28 deficiency anemia 9.6 HBB THPO

Graphical network of the top 20 diseases related to Splenic Sequestration:



Diseases related to Splenic Sequestration

Symptoms & Phenotypes for Splenic Sequestration

Drugs & Therapeutics for Splenic Sequestration

Drugs for Splenic Sequestration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desogestrel Approved Phase 4 54024-22-5 40973
2
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
3 Contraceptive Agents Phase 4
4 Contraceptives, Oral Phase 4
5
Ethylene Phase 4 74-85-1 6325
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Progestins Phase 4
10
Hydroxyurea Approved Phase 3,Phase 2 127-07-1 3657
11
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
12 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
13 Antidotes Phase 3
14 Anti-Infective Agents Phase 3
15 Antioxidants Phase 3
16 Antiviral Agents Phase 3
17 Expectorants Phase 3
18 N-monoacetylcystine Phase 3
19 Protective Agents Phase 3
20 Respiratory System Agents Phase 3
21 Antibodies Phase 2
22 Antibodies, Monoclonal Phase 2
23 Immunoglobulins Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
2 Novel Use Of Hydroxyurea in an African Region With Malaria Completed NCT01976416 Phase 3 Hydroxyurea;Placebo
3 N-Acetylcysteine in Patients With Sickle Cell Disease Completed NCT01849016 Phase 3 N-Acetylcysteine;Placebo
4 Sparing Conversion to Abnormal TCD (Transcranial Doppler) Elevation (SCATE) Terminated NCT01531387 Phase 3 Hydroxyurea
5 Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
6 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Recruiting NCT03264989 Phase 2 crizanlizumab
7 EXTEND EXpanding Treatment for Existing Neurological Disease Recruiting NCT02556099 Phase 2 Hydroxyurea
8 Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients Not yet recruiting NCT03474965 Phase 2 Crizanlizumab
9 The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00971698
10 Prognostic Factors of Acute Splenic Sequestration Active, not recruiting NCT01207037 Not Applicable
11 Dense Red Blood Cells in Sickle Cell Children Active, not recruiting NCT02887118
12 European Sickle Cell Disease Cohort - Hydroxyurea Active, not recruiting NCT02516579 Siklos

Search NIH Clinical Center for Splenic Sequestration

Genetic Tests for Splenic Sequestration

Anatomical Context for Splenic Sequestration

MalaCards organs/tissues related to Splenic Sequestration:

41
Spleen

Publications for Splenic Sequestration

Articles related to Splenic Sequestration:

(show top 50) (show all 96)
# Title Authors Year
1
Ceftriaxone-induced drug reaction mimicking acute splenic sequestration crisis in a child with hemoglobin SC disease. ( 29473172 )
2018
2
Association of the <i>SOD2</i> Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia. ( 29531649 )
2018
3
Double whammy- acute splenic sequestration crisis in patient with aplastic crisis due to acute parvovirus infection. ( 28808516 )
2017
4
Acute Splenic Sequestration Crisis After Red Blood Cell Exchange for Acute Chest Syndrome in an Adult With Sickle I^-Thalassemia: What Went Wrong? ( 29205801 )
2017
5
Acute Splenic Sequestration Crisis in a 70-Year-Old Patient With Hemoglobin SC Disease. ( 27047980 )
2016
6
Acute Splenic Sequestration Crisis in Adult Sickle Cell Disease: A Report of 16 Cases. ( 26287797 )
2015
7
Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia. ( 23657515 )
2013
8
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients. ( 22224796 )
2012
9
Partial Splenic Embolization as a Bridge to Total Knee Replacement for a Patient with Severe Thrombocytopenia due to Cirrhosis and Splenic Sequestration. ( 23304579 )
2012
10
Elevated IL-1I+ and CXCL10 serum levels occur in patients with homozygous sickle cell disease and a history of acute splenic sequestration. ( 22674409 )
2012
11
Acute splenic sequestration crisis in an adult with sickle cell anaemia. ( 22411649 )
2012
12
Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats. ( 21185577 )
2011
13
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease. ( 19418550 )
2009
14
Acute splenic sequestration in children with sickle cell anemia. ( 19668914 )
2009
15
Partial splenectomy prevents splenic sequestration crises in sickle cell disease. ( 19944213 )
2009
16
Acute splenic sequestration in a cohort of children with sickle cell anemia. ( 19319450 )
2009
17
Acute splenic sequestration complicating sickle cell disease. ( 18331593 )
2008
18
Fever of unclear origin and cytopenia because of acute splenic sequestration in a young immunocompetent carrier of beta-globin mutation for Hb Valletta. ( 19092326 )
2008
19
Acute splenic sequestration in an adult with hemoglobin S-C disease. ( 19091280 )
2008
20
Determination of hemolytic anemia through the study of (51)Cr red cell survival and splenic sequestration. ( 18483142 )
2008
21
Postpartum acute splenic sequestration in sickle cell disease. ( 18604687 )
2008
22
Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. ( 18084762 )
2008
23
Acute splenic sequestration crisis in adults with sickle cell anemia. ( 16924644 )
2007
24
Acute splenic sequestration crisis in an adult with sickle beta-thalassemia. ( 16705454 )
2006
25
Acute splenic sequestration in female children with sickle cell disease in the North of Jordan. ( 16951418 )
2006
26
Acute splenic sequestration crisis in adults with hemoglobin S-C disease: a report of nine cases. ( 16463155 )
2006
27
Fatal splenic sequestration crisis with multiorgan failure in an adult woman with sickle cell-beta+ thalassemia. ( 15767820 )
2005
28
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease. ( 15108841 )
2004
29
Sudden unexpected death in a patient with splenic sequestration and sickle cell-beta+-thalassemia syndrome. ( 11305454 )
2001
30
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. ( 17264555 )
2001
31
Aplastic crisis and acute splenic sequestration crisis. ( 10779041 )
2000
32
CT imaging of splenic sequestration in sickle cell disease. ( 11149089 )
2000
33
Laparoscopic splenectomy for splenic sequestration crisis. ( 10806537 )
2000
34
Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration. ( 9607493 )
1998
35
Case report: splenomegaly and splenic sequestration in an adult with sickle cell anemia. ( 8969620 )
1996
36
Case report: splenic sequestration and multiorgan failure as the presenting manifestation of hemoglobin SC disease. ( 8615389 )
1996
37
Partial splenectomy in children with sickle cell disease and repeated episodes of splenic sequestration. ( 8936465 )
1996
38
Splenectomy and acute splenic sequestration crises in sickle cell disease. ( 24057466 )
1996
39
Acute splenic sequestration in the absence of palpable splenomegaly. ( 8166373 )
1994
40
Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease. ( 8463907 )
1993
41
Splenic sequestration associated with sickle cell trait and hereditary spherocytosis. ( 1585908 )
1992
42
Acute splenic sequestration crisis in sickle cell disease: early detection and treatment. ( 1564621 )
1992
43
A fatal case of acute splenic sequestration in a 53-year-old woman with sickle-hemoglobin C disease. ( 1731518 )
1992
44
Acute splenic sequestration in a five-week-old infant with sickle cell disease. ( 1731016 )
1992
45
SPECT versus planar scintigraphy for quantification of splenic sequestration of 111In-labelled platelets. ( 1491841 )
1992
46
Massive splenic infarction in doubly abnormal heterozygous sickling disorders. A new complication of acute splenic sequestration syndrome. ( 1815406 )
1991
47
Pulmonary, hepatic and splenic sequestration of technetium-99m labelled autologous rabbit granulocytes: scintigraphic cell distributions after intravenous and intraarterial injections, exsanguination and intraarterial injection of cells passed through an intermediary host. ( 1962525 )
1991
48
Case report: splenic infarction and acute splenic sequestration in adults with hemoglobin SC disease. ( 1772123 )
1991
49
Fatal splenic sequestration crisis in adult sickle cell-beta thalassaemia. ( 1758801 )
1991
50
Acute splenic sequestration in Jamaican adults with homozygous sickle cell disease: a role of alpha thalassaemia. ( 2025582 )
1991

Variations for Splenic Sequestration

Expression for Splenic Sequestration

Search GEO for disease gene expression data for Splenic Sequestration.

Pathways for Splenic Sequestration

GO Terms for Splenic Sequestration

Cellular components related to Splenic Sequestration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 ALAD HBB KLK8 THPO
2 ficolin-1-rich granule lumen GO:1904813 9.16 ALAD HBB
3 extracellular region GO:0005576 9.02 ALAD BCAM HBB KLK8 THPO

Sources for Splenic Sequestration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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