MCID: SPL008
MIFTS: 31

Splenic Tuberculosis

Categories: Immune diseases, Infectious diseases

Aliases & Classifications for Splenic Tuberculosis

MalaCards integrated aliases for Splenic Tuberculosis:

Name: Splenic Tuberculosis 12 15 17
Tuberculosis, Splenic 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9305
ICD9CM 34 017.7
MeSH 43 D014400
SNOMED-CT 67 28399005
ICD10 32 A18.85
UMLS 71 C0041331

Summaries for Splenic Tuberculosis

Disease Ontology : 12 An abdominal tuberculosis that results in formation of granulomas or abscesses located in spleen.

MalaCards based summary : Splenic Tuberculosis, also known as tuberculosis, splenic, is related to deficiency anemia and mycobacterium tuberculosis 1. An important gene associated with Splenic Tuberculosis is GRP (Gastrin Releasing Peptide), and among its related pathways/superpathways are Arachidonic acid metabolism and NRF2 pathway. Affiliated tissues include spleen, liver and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Splenic Tuberculosis

Diseases related to Splenic Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 28.7 GGTLC3 GGT2 GGT1
2 mycobacterium tuberculosis 1 10.6
3 splenomegaly 10.4
4 extrapulmonary tuberculosis 10.2
5 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.1
6 neutropenia 10.1
7 miliary tuberculosis 10.1
8 purpura 10.0
9 hypersplenism 10.0
10 thrombocytopenic purpura, autoimmune 9.9
11 pancytopenia 9.9
12 thrombocytopenia 9.9
13 pulmonary tuberculosis 9.9
14 liver cirrhosis 9.9
15 hemolytic anemia 9.9
16 sickle cell disease 9.9
17 spondyloarthropathy 1 9.8
18 anemia, autoimmune hemolytic 9.8
19 immune deficiency disease 9.8
20 myelofibrosis 9.8
21 pancreatic cancer 9.8
22 leukemia, acute myeloid 9.8
23 human immunodeficiency virus type 1 9.8
24 melioidosis 9.8
25 abdominal tuberculosis 9.8
26 lymphoproliferative syndrome 9.8
27 portal hypertension 9.8
28 sarcoma 9.8
29 choroiditis 9.8
30 inflammatory spondylopathy 9.8
31 acute leukemia 9.8
32 alcoholic liver cirrhosis 9.8
33 thrombocytopenia due to platelet alloimmunization 9.8
34 lymphadenitis 9.8
35 pericarditis 9.8
36 macrocytic anemia 9.8
37 splenic abscess 9.8
38 splenic infarction 9.8
39 hemangioma 9.8
40 hemangioma of spleen 9.8
41 spindle cell sarcoma 9.8
42 pustulosis of palm and sole 9.8
43 lymph node tuberculosis 9.8
44 spondylitis 9.8
45 monoclonal gammopathy of uncertain significance 9.8
46 myeloid leukemia 9.8
47 crohn's disease 9.8
48 psoriasis 9.8
49 banti's syndrome 9.8
50 multifocal choroiditis 9.8

Graphical network of the top 20 diseases related to Splenic Tuberculosis:



Diseases related to Splenic Tuberculosis

Symptoms & Phenotypes for Splenic Tuberculosis

GenomeRNAi Phenotypes related to Splenic Tuberculosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.23 GGT2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-143 9.23 GGT1 GGT2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-169 9.23 GGT1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.23 GGT1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.23 GGT2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 9.23 GGT1 GGT2

Drugs & Therapeutics for Splenic Tuberculosis

Search Clinical Trials , NIH Clinical Center for Splenic Tuberculosis

Cochrane evidence based reviews: tuberculosis, splenic

Genetic Tests for Splenic Tuberculosis

Anatomical Context for Splenic Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Splenic Tuberculosis:

19
Spleen

MalaCards organs/tissues related to Splenic Tuberculosis:

40
Spleen, Liver, Bone Marrow, Bone, Colon, Lung, Myeloid

Publications for Splenic Tuberculosis

Articles related to Splenic Tuberculosis:

(show top 50) (show all 140)
# Title Authors PMID Year
1
Spleenic Abscess As A Complication Of Extrapulmonay Tuberculosis. 61
31535530 2019
2
Solitary Splenic Tuberculosis in an Immunocompetent Child: A Case Report. 61
31565614 2019
3
Isolated splenic tuberculosis presenting as an unusual splenic mass. 61
30531044 2018
4
Splenic tuberculosis and multifocal serpiginoid choroiditis. 61
28798995 2018
5
Splenic tuberculosis: a comprehensive review of literature. 61
30426945 2018
6
Isolated Splenic Cold Abscesses in an Immunocompetent Individual. 61
30038737 2018
7
Isolated cystic lymphangiomatosis of spleen in an adult: a diagnostic conundrum. 61
29622712 2018
8
Splenic tuberculosis in an immunocompetent patient can be managed conservatively: a case report. 61
26567167 2018
9
Splenic tuberculosis. 61
29253708 2018
10
Challenges and Results of Laparoscopic Splenectomy for Hematological Diseases in a Developing Country. 61
30155296 2018
11
Portal Venous Thrombosis-Disseminated Tuberculosis in Rheumatoid Arthritis. 61
28764227 2017
12
Isolated splenic tuberculosis diagnosed by endoscopic ultrasound-guided fine needle aspiration. 61
28410696 2017
13
Isolated splenic tuberculosis with subsequent paradoxical deterioration: a case report. 61
28438221 2017
14
Spontaneous splenic rupture in an acute leukemia patient with splenic tuberculosis: A case report. 61
28357096 2017
15
Isolated splenic tuberculosis detected only on FDG-PET. 61
30363184 2017
16
Isolated Splenic Cold Abscesses with Perisplenic Extension: Treated Successfully without Splenectomy. 61
28912985 2017
17
Hepatosplenic tuberculosis simulating secondary malignant lesions with cholangitis. 61
27324380 2016
18
Solitary splenic tuberculosis: a case report and review of the literature. 61
27250119 2016
19
Splenic Tuberculosis--Case Report. 61
27172532 2016
20
Splenic tuberculosis in a patient with newly diagnosed advanced HIV infection. 61
27635384 2016
21
A Case of Splenic Tuberculosis Forming a Gastro-splenic Fistula. 61
26387701 2015
22
[Hepato-splenic tuberculosis]. 61
25224582 2015
23
A case of isolated splenic tuberculosis. 61
25667987 2015
24
Bilateral choroidal tuberculoma in miliary tuberculosis - report of a case. 61
25861395 2015
25
Isolated Splenic Tuberculosis without Any Radiological Focal Lesion. 61
25628658 2015
26
Systemic spread of tuberculosis after surgery for a splenic tuberculous abscess without postoperational antituberculosis treatment: a case report. 61
26635478 2015
27
Inflammatory pseudotumour of the spleen associated with splenic tuberculosis. 61
25548610 2014
28
Disseminated tuberculosis with splenic tuberculosis abscess rupture. A rare presentation. 61
25271747 2014
29
PUO--a rare (and forgotten) cause! 61
25906529 2014
30
A rare presentation of splenic tuberculosis with a pseudocyst. 61
24825554 2014
31
Deep vein thrombosis and tuberculosis: a causative link? 61
24859543 2014
32
Isolated splenic tuberculosis in an immunocompetent patient. 61
24599429 2014
33
Splenic tuberculosis: a rare entity. 61
24414191 2014
34
Spontaneous Splenic Rupture as a Paradoxical Reaction during Treatment for Splenic Tuberculosis. 61
24348671 2013
35
Primary splenic tubercular abscess in an immunocompromised patient-rapid diagnosis by line probe assay. 61
24179920 2013
36
Splenic tuberculosis presenting as fever of unknown origin with severe neutropenia. 61
23777575 2013
37
Isolated tuberculosis of the spleen: A case report and review of literature. 61
24426436 2013
38
Idiopathic thrombocytopenic purpura associated with splenic tuberculosis: case report. 61
23524902 2013
39
Splenic tuberculosis presenting as ascites in immunocompetant patient. 61
23634345 2013
40
Splenic tuberculosis. 61
23268618 2012
41
[Symptomatic hypercalcemia presenting as a case of isolated splenic tuberculosis]. 61
22809966 2012
42
Splenic tuberculosis diagnosed by endoscopic ultrasound-guided fine needle aspiration. 61
24949357 2012
43
[Splenic tuberculosis in HIV patient]. 61
21377234 2012
44
Isolated tubercular splenic abscess: can we defer splenectomy? Our single experience with anti-tuberculous therapy alone. 61
22361772 2012
45
Splenic tuberculosis in a patient with ankylosing spondylitis treated with adalimumab. 61
22257918 2011
46
A case of mass-forming splenic tuberculosis: MRI findings with emphasis of diffusion-weighted imaging characteristics. 61
21394320 2011
47
A 52-year-old Cuban immigrant with weight loss, dyspnea, and fever. Splenic tuberculosis. 61
21217183 2011
48
Isolated splenic tuberculosis: A case report. 61
21607149 2010
49
Splenic tuberculosis in a patient with Crohn's disease on infliximab: case report. 61
19591134 2010
50
Tuberculosis of the spleen as a cause of Fever of unknown origin and splenomegaly. 61
20479918 2010

Variations for Splenic Tuberculosis

Expression for Splenic Tuberculosis

Search GEO for disease gene expression data for Splenic Tuberculosis.

Pathways for Splenic Tuberculosis

GO Terms for Splenic Tuberculosis

Biological processes related to Splenic Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.61 GGTLC3 GGT2 GGT1
2 response to lipopolysaccharide GO:0032496 9.48 GGT2 GGT1
3 response to estradiol GO:0032355 9.46 GGT2 GGT1
4 regulation of inflammatory response GO:0050727 9.4 GGT2 GGT1
5 response to tumor necrosis factor GO:0034612 9.37 GGT2 GGT1
6 zymogen activation GO:0031638 9.32 GGT2 GGT1
7 regulation of immune system process GO:0002682 9.26 GGT2 GGT1
8 peptide modification GO:0031179 9.16 GGT2 GGT1
9 glutathione catabolic process GO:0006751 9.13 GGTLC3 GGT2 GGT1
10 leukotriene D4 biosynthetic process GO:1901750 8.8 GGTLC3 GGT2 GGT1

Molecular functions related to Splenic Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyltransferase activity GO:0000048 8.96 GGT2 GGT1
2 glutathione hydrolase activity GO:0036374 8.8 GGTLC3 GGT2 GGT1

Sources for Splenic Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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