Aliases & Classifications for Spondylarthropathy

MalaCards integrated aliases for Spondylarthropathy:

Name: Spondylarthropathy 53
Spondylarthropathies 55 73

Classifications:



External Ids:

UMLS 73 C0949691

Summaries for Spondylarthropathy

MalaCards based summary : Spondylarthropathy, also known as spondylarthropathies, is related to spondyloarthropathy 1 and spondylitis, and has symptoms including sciatica An important gene associated with Spondylarthropathy is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Adalimumab and Sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and spinal cord, and related phenotypes are cellular and hematopoietic system

Wikipedia : 76 Spondyloarthropathy or spondyloarthrosis refers to any joint disease of the vertebral column. As such,... more...

Related Diseases for Spondylarthropathy

Diseases related to Spondylarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 32.3 CD163 NOD2 TLR4 TNF
2 spondylitis 30.7 LTA NOD2 TNF
3 arthritis 30.4 COL2A1 CSF1 LTA NOD2 PTGS2 TNF
4 crohn's disease 30.3 HP NOD2 TNF
5 colitis 30.1 NOD2 PTGS2 TLR4 TNF
6 adult-onset still's disease 29.9 CSF1 TNF TNFRSF1A
7 psoriatic arthritis 29.9 LTA NOD2 TNF TNFRSF1A
8 ulcerative colitis 29.8 NOD2 TLR4 TNF
9 rheumatoid arthritis 29.4 CD80 CSF1 ITGAL PTGS2 TLR2 TLR4
10 inflammatory bowel disease 29.0 CD40 ITGAL LTA NOD2 PTGS2 TLR2
11 spondyloarthropathy 11.7
12 enthesitis-related juvenile idiopathic arthritis 11.1
13 streptococcal toxic-shock syndrome 10.2 LTA TNF
14 ileocolitis 10.2 NOD2 TNF
15 transient hypogammaglobulinemia 10.2 LTA TNF
16 granulomatous dermatitis 10.2 NOD2 TNF
17 null-cell leukemia 10.2 LTA TNF
18 tympanosclerosis 10.2 COL2A1 TLR4
19 pouchitis 10.2 NOD2 TLR4
20 leukoregulin 10.2 CSF1 PTGS2
21 melancholia 10.2 HP TNF
22 chronic gonococcal salpingitis 10.2 TNF TNFRSF1A
23 idiopathic achalasia 10.2 LTA TNF
24 prosthetic joint infection 10.2 TLR2 TLR4
25 typhoid fever 10.2 LTA TLR4 TNF
26 retinitis pigmentosa 75 10.1 TNF TNFRSF1A
27 macrophage activation syndrome 10.1 CD163 TNF
28 lymphadenitis 10.1 NOD2 TLR4 TNF
29 synovitis 10.1
30 cystitis 10.1 PTGS2 TLR4 TNF
31 rheumatic disease 10.1 CD163 PTGS2 TNF
32 juvenile ankylosing spondylitis 10.1 CD80 TNF
33 bone inflammation disease 10.1 COL2A1 PTGS2 TNF
34 trench fever 10.1 TLR2 TLR4 TNF
35 anterior uveitis 10.1 TLR2 TLR4 TNF
36 alveolar echinococcosis 10.1 TLR2 TLR4 TNF
37 echinococcosis 10.1 TLR2 TLR4 TNF
38 scrub typhus 10.1 TLR2 TLR4 TNF
39 middle ear disease 10.1 TLR2 TLR4 TNF
40 paracoccidioidomycosis 10.1 TLR2 TLR4 TNF
41 bacterial vaginosis 10.1 TLR2 TLR4 TNF
42 melioidosis 10.1 TLR2 TLR4 TNF
43 legionellosis 10.1 TLR2 TLR4 TNF
44 guillain-barre syndrome 10.1 HP TNF TNFRSF1A
45 post-transplant lymphoproliferative disease 10.1 LTA TNF TNFRSF1A
46 filariasis 10.1 TLR2 TLR4 TNF
47 primary bacterial infectious disease 10.1 TLR2 TLR4 TNF
48 cutaneous leishmaniasis 10.1 TLR2 TLR4 TNF
49 leishmaniasis 10.1 TLR2 TLR4 TNF
50 visceral leishmaniasis 10.1 TLR2 TLR4 TNF

Graphical network of the top 20 diseases related to Spondylarthropathy:



Diseases related to Spondylarthropathy

Symptoms & Phenotypes for Spondylarthropathy

UMLS symptoms related to Spondylarthropathy:


sciatica

MGI Mouse Phenotypes related to Spondylarthropathy:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.37 CD163 CD80 COL2A1 CSF1 HP ITGAL
2 hematopoietic system MP:0005397 10.37 CD163 CD40 CD80 CSF1 HP ITGAL
3 immune system MP:0005387 10.37 CD163 CD40 CD80 COL2A1 CSF1 HP
4 homeostasis/metabolism MP:0005376 10.32 CD163 CD40 COL2A1 CSF1 HP ITGAL
5 cardiovascular system MP:0005385 10.27 CD163 COL2A1 CSF1 HP LTA PTGS2
6 mortality/aging MP:0010768 10.17 COL2A1 CSF1 HP LTA MARCO NOD2
7 endocrine/exocrine gland MP:0005379 10.14 CD40 CD80 CSF1 LTA PTGS2 TLR2
8 liver/biliary system MP:0005370 10.11 COL2A1 CSF1 HP LTA PTGS2 TLR2
9 digestive/alimentary MP:0005381 10.09 COL2A1 NOD2 PTGS2 TLR2 TLR4 TNF
10 adipose tissue MP:0005375 10.05 COL2A1 PTGS2 TLR2 TLR4 TNF TNFRSF1A
11 nervous system MP:0003631 10.02 CD40 CD80 COL2A1 CSF1 LTA PTGS2
12 limbs/digits/tail MP:0005371 9.95 COL2A1 CSF1 LTA TLR4 TNF TNFRSF1A
13 muscle MP:0005369 9.95 CD163 CSF1 PTGS2 TLR2 TLR4 TNF
14 neoplasm MP:0002006 9.91 HP ITGAL PTGS2 TLR2 TLR4 TNF
15 respiratory system MP:0005388 9.81 CD163 COL2A1 CSF1 LTA PTGS2 TLR2
16 renal/urinary system MP:0005367 9.8 CD40 COL2A1 HP PTGS2 TLR2 TLR4
17 skeleton MP:0005390 9.65 CD40 COL2A1 CSF1 LTA NOD2 PTGS2
18 vision/eye MP:0005391 9.23 CD163 COL2A1 CSF1 LTA PTGS2 TLR4

Drugs & Therapeutics for Spondylarthropathy

Drugs for Spondylarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 229)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 2,Phase 3,Not Applicable 331731-18-1 16219006
2
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
3
Etanercept Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 185243-69-0
4
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
5
Pamidronate Approved Phase 4 40391-99-9 4674
6
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
7
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 170277-31-3
8
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
9
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
10
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
11
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Aceclofenac Approved, Investigational Phase 4 89796-99-6
14
Tofacitinib Approved, Investigational Phase 4,Phase 3,Phase 2 477600-75-2
15
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 73590-58-6 4594
16
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2 71125-38-7 54677470 5281106
17
Indomethacin Approved, Investigational Phase 4,Phase 3 53-86-1 3715
18
Hydroxychloroquine Approved Phase 4,Phase 3 118-42-3 3652
19 Ixekizumab Approved, Investigational Phase 4,Phase 3 1143503-69-8
20
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
22 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
23 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
25 beta-endorphin Phase 4
26 Melanocyte-Stimulating Hormones Phase 4
27 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
28 Adrenocorticotropic Hormone Phase 4
29 Hormones Phase 4,Phase 2,Phase 3,Phase 1
30 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
31 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Not Applicable
32 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3,Not Applicable
36 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
37 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
38 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Not Applicable
40 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Natriuretic Agents Phase 4
42 Natriuretic Peptide, Brain Phase 4
43 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Vaccines Phase 4,Phase 2
47 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Vitamin B9 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 552)
# Name Status NCT ID Phase Drugs
1 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
2 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
3 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
4 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
5 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
6 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
7 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
8 Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Completed NCT01604629 Phase 4 Reduced doses of anti-TNF;Stable doses of anti-TNF
9 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4 Etanercept
10 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4 golimumab;Pamidronate
11 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
12 Effects of Different Antirheumatic Treatments of Arthritis on Antibody Response Following Vaccination Using Prevenar® Completed NCT00828997 Phase 4
13 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
14 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Completed NCT03190603 Phase 4 Celecoxib
15 HUmira in Psoriatic Arthritis Completed NCT01465438 Phase 4 Adalimumab
16 Efficacy and Safety of Loxoprofen Hydrogel Patch in Patients With Ankylosing Spondylitis Completed NCT03800797 Phase 4 Loxoprofen sodium hydrogel patch;Loxoprofen sodium tablet
17 Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis Completed NCT00245960 Phase 4 etanercept
18 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
19 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
20 Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis Completed NCT00432406 Phase 4 Infliximab;Etanercept
21 REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®) Completed NCT00127842 Phase 4 Etanercept
22 Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Active Ankylosing Spondylitis Completed NCT01934933 Phase 4 celebrex;Enbrel;Enbrel plus Celebrex
23 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
24 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
25 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
26 Prevalence of Psoriatic Arthritis in Adults With Psoriasis: An Estimate From Dermatology Practice Completed NCT01147874 Phase 4
27 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
28 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
29 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
30 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
31 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
32 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
33 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
34 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
35 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
36 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
37 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
38 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
39 Study Evaluating Etanercept and Methotrexate in Plaque Psoriasis Completed NCT00161655 Phase 4 Etanercept;Methotrexate
40 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
41 Enbrel® in Psoriatic Arthritis Completed NCT00111124 Phase 4 Enbrel®
42 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
43 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
44 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
45 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
46 Centocor Microarray Study of Patients Completed NCT00462072 Phase 4 Infliximab
47 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
48 Risk of Tuberculous and Other Infections in Patients of Spondyloarthritis Treated With Tofacitinib in Bangladesh Recruiting NCT03504072 Phase 4 Tofacitinib 5 mg,;Etanercept
49 Efficacy, Safety, and Tolerability Study of Apremilast to Treat Early Oligoarticular Psoriatic Arthritis. Recruiting NCT03747939 Phase 4 Apremilast (CC-10004)
50 Clinical Impact of Acthar in the Psoriatic Arthritis Patient (CLIPS) Recruiting NCT03419650 Phase 4 ACTHar

Search NIH Clinical Center for Spondylarthropathy

Genetic Tests for Spondylarthropathy

Anatomical Context for Spondylarthropathy

MalaCards organs/tissues related to Spondylarthropathy:

41
T Cells, Bone, Spinal Cord, Neutrophil, Lung, Heart

Publications for Spondylarthropathy

Articles related to Spondylarthropathy:

(show top 50) (show all 240)
# Title Authors Year
1
A patient with spondylarthropathy treated with TNF-α inhibitors presenting with clinical findings suspicious of metastatic cancer disease. ( 30137507 )
2018
2
A patient with spondylarthropathy treated with TNF-α inhibitors presenting with clinical findings suspicious of metastatic cancer disease. ( 30376121 )
2018
3
Immune cell transcript modules reveal leukocyte heterogeneity in synovial biopsies of seronegative spondylarthropathy patients. ( 25526985 )
2014
4
Severe deafness associated with Crohn's disease and spondylarthropathy: successful treatment with anti-TNF. ( 23221328 )
2013
5
Osteoporosis and osteoarthritis, rheumatoid arthritis and spondylarthropathies. ( 24085651 )
2013
6
Collagenous colitis and spondylarthropathy. ( 22701491 )
2012
7
Performance of the assessment in Spondyloarthritis International Society classification for axial and peripheral spondyloarthritis in an established clinical cohort: comparison with criteria sets of Amor and the European Spondylarthropathy Study Group. ( 22337240 )
2012
8
Late-onset spondylarthropathy mimicking multiple osteoblastic metastases. ( 22771134 )
2012
9
Lack of efficacy of abatacept in axial spondylarthropathies refractory to tumor-necrosis-factor inhibition. ( 21497538 )
2012
10
High frequency of vertebral fractures in early spondylarthropathies. ( 21927925 )
2012
11
Novel development in extraintestinal manifestations and spondylarthropathy. ( 21640926 )
2011
12
Low bone mineral density is related to male gender and decreased functional capacity in early spondylarthropathies. ( 20697764 )
2011
13
Measures of symptoms and disease status in ankylosing spondylitis: Ankylosing Spondylitis Disease Activity Score (ASDAS), Ankylosing Spondylitis Quality of Life Scale (ASQoL), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Global Score (BAS-G), Bath Ankylosing Spondylitis Metrology Index (BASMI), Dougados Functional Index (DFI), and Health Assessment Questionnaire for the Spondylarthropathies (HAQ-S). ( 22588768 )
2011
14
Infliximab for treating axial spondylarthropathy in everyday practice. ( 19064331 )
2009
15
Chronic, eventually fatal, Kawasaki-like disease in an adult with spondylarthropathy responding to IVIG therapy. ( 19464220 )
2009
16
Recurrence of spondylarthropathy among first-degree relatives of patients: a systematic cross-sectional study. ( 18413442 )
2009
17
The Bath metrology index as assessed by a trained and an untrained rater in patients with spondylarthropathy: a study of intra- and inter-rater agreements. ( 18726550 )
2009
18
Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies. ( 19468997 )
2009
19
Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies. ( 19470150 )
2009
20
Imaging of the sacroiliac joint involvement in seronegative spondylarthropathies. ( 19526194 )
2009
21
Six-month response to anti-TNF drugs in axial spondylarthropathy according to the fulfillment or not of New-York criteria for ankylosing spondylitis or French recommendations for anti-TNF use. A "real life" retrospective study on 175 patients. ( 18848489 )
2008
22
Impact of three anti-TNFalpha biologics on existing and emergent autoimmunity in rheumatoid arthritis and spondylarthropathy patients. ( 18587633 )
2008
23
Ankylosing spondylitis and spondylarthropathy presenting with a clinical picture of adult onset Still's disease: case series. ( 18658204 )
2008
24
Association of hereditary angioneurotic edema with spondylarthropathy: report of a case. ( 17980638 )
2008
25
An exceptional manifestation of spondylarthropathy: Destructive proximal tibio-fibular arthritis. ( 18406190 )
2008
26
Risk factors of atherosclerosis in patients with spondylarthropathies: comment on the article by Gonzalez-Juanatey et al. ( 18311767 )
2008
27
Retrospective study of juvenile spondylarthropathies in Croatia over the last 11 years. ( 18799108 )
2008
28
Reiter syndrome triggered by adalimumab (Humira) and leflunomide (Arava) in a patient with ankylosing spondylarthropathy and Crohn disease. ( 17199598 )
2007
29
25 mg etanercept once weekly in rheumatoid arthritis and spondylarthropathy. ( 17337351 )
2007
30
Disappearing condyles in a patient with seronegative spondylarthropathy. ( 16368170 )
2007
31
A hidradenitis suppurativa related SAPHO case associated with features resembling spondylarthropathy and proteinuria. ( 16680392 )
2007
32
First appearance of Crohn's disease following infliximab treatment for spondylarthropathy. ( 17506005 )
2007
33
Magnetic resonance imaging guided corticosteroid injection of sacroiliac joints in patients with spondylarthropathy. Are multiple injections more beneficial? ( 16010559 )
2006
34
Intravenous application of omega-3 fatty acids in a patient with active spondylarthropathy--a case report. ( 16220223 )
2006
35
Efficacy of tumour necrosis factor blockers in reducing uveitis flares in patients with spondylarthropathy: a retrospective study. ( 16901960 )
2006
36
Spondylarthropathy striking prevalence in a 19th-20th century Portuguese collection. ( 16564195 )
2006
37
Collagenous colitis and spondylarthropathy. ( 16739191 )
2006
38
Spondylarthropathies in children--are they different from those in adults? ( 16546059 )
2006
39
Synovial biomarkers in the spondylarthropathies. ( 16763455 )
2006
40
Transient efficacy of pulse pamidronate treatment in active spondylarthropathies: an open study of 35 cases. ( 16870109 )
2006
41
Anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondylarthropathy. ( 15986366 )
2005
42
Mesalazine-associated acute tubulointerstitial nephritis in a patient with spondylarthropathy. ( 16222356 )
2005
43
Two major spondylarthropathy phenotypes are distinguished by pattern analysis in multiplex families. ( 15818650 )
2005
44
A study of ten Japanese patients with seronegative spondylarthropathy: a tentative proposal. ( 17029088 )
2005
45
Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy. ( 15986373 )
2005
46
Genetic control of experimental spondylarthropathy. ( 16059927 )
2005
47
Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy: a role for scintigraphy with 99mTc-infliximab. ( 15818709 )
2005
48
Bisphosphonates as anti-inflammatory agents in ankylosing spondylitis and spondylarthropathies. ( 15709881 )
2005
49
Late-onset ankylosing spondylitis and related spondylarthropathies: clinical and radiological characteristics and pharmacological treatment options. ( 15974637 )
2005
50
Low dose of infliximab is inadequate in most patients with spondylarthropathies. ( 16095121 )
2005

Variations for Spondylarthropathy

Expression for Spondylarthropathy

Search GEO for disease gene expression data for Spondylarthropathy.

Pathways for Spondylarthropathy

Pathways related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 CD40 CD80 CSF1 HP ITGAL LTA
2
Show member pathways
13.81 CD40 CD80 COL2A1 CSF1 ITGAL LTA
3
Show member pathways
13.63 CD40 CD80 CSF1 LTA PTGS2 TLR4
4
Show member pathways
13.32 CD40 CD80 CSF1 LTA NOD2 PTGS2
5
Show member pathways
13.31 CD40 CD80 CSF1 ITGAL LTA TLR2
6
Show member pathways
13.24 CD40 CD80 CSF1 LTA TNF TNFRSF1A
7
Show member pathways
12.99 PTGS2 TLR2 TLR4 TNF TNFRSF1A
8
Show member pathways
12.96 CD40 CD80 NOD2 TLR2 TLR4 TNF
9
Show member pathways
12.94 COL2A1 CSF1 PTGS2 TLR2 TLR4 TNF
10
Show member pathways
12.88 CD40 COL2A1 ITGAL LTA TNF TNFRSF1A
11
Show member pathways
12.86 CD40 CD80 ITGAL LTA TNF TNFRSF1A
12
Show member pathways
12.76 LTA TLR2 TLR4 TNF TNFRSF1A
13
Show member pathways
12.67 CD40 LTA TLR2 TLR4 TNF TNFRSF1A
14
Show member pathways
12.6 CD40 LTA TLR2 TLR4 TNF TNFRSF1A
15
Show member pathways
12.57 CD40 CD80 TNF TNFRSF1A
16
Show member pathways
12.54 NOD2 TLR2 TLR4 TNF
17 12.51 PTGS2 TLR2 TNF TNFRSF1A
18 12.42 CD40 ITGAL LTA TNF TNFRSF1A
19 12.27 CD40 ITGAL TLR2 TNF
20 12.2 NOD2 TLR2 TLR4 TNF TNFRSF1A
21 12.15 PTGS2 TLR2 TLR4 TNF TNFRSF1A
22
Show member pathways
12.15 CD40 PTGS2 TLR2 TLR4 TNF TNFRSF1A
23 12.01 COL2A1 PTGS2 TLR4 TNF
24 11.99 CSF1 TNF TNFRSF1A
25
Show member pathways
11.99 CD80 LTA TLR2 TLR4 TNF
26
Show member pathways
11.96 CD40 MARCO TLR2 TLR4 TNF
27 11.9 CD163 CD80 CSF1 ITGAL TNF
28
Show member pathways
11.89 CD163 HP MARCO
29 11.85 TLR2 TLR4 TNF
30 11.83 ITGAL MARCO TLR2 TLR4
31 11.73 CD163 CSF1 TNF
32
Show member pathways
11.72 CD40 TNF TNFRSF1A
33 11.71 TLR4 TNF TNFRSF1A
34 11.67 CSF1 LTA NOD2 PTGS2 TNF TNFRSF1A
35
Show member pathways
11.64 PTGS2 TNF TNFRSF1A
36 11.62 CD163 CD40 CD80 PTGS2 TNF
37 11.61 CD40 CD80 COL2A1
38 11.57 TLR2 TLR4 TNF
39 11.56 LTA TLR4 TNF TNFRSF1A
40
Show member pathways
11.53 LTA TNF TNFRSF1A
41 11.48 CSF1 TLR2 TLR4 TNF
42 11.41 CD80 CSF1 PTGS2 TNF TNFRSF1A
43 11.41 CD40 LTA PTGS2 TLR4 TNF TNFRSF1A
44 11.34 CD40 ITGAL TLR2 TLR4 TNF
45 11.33 CD40 CD80 TNFRSF1A
46 11.31 CD40 MARCO TLR4
47 11.19 CD80 CSF1 LTA TNF
48 11.15 NOD2 TNF TNFRSF1A
49 11.05 CD80 CSF1 ITGAL TLR2 TLR4 TNF
50 11 CD80 COL2A1 CSF1 ITGAL LTA TNF

GO Terms for Spondylarthropathy

Cellular components related to Spondylarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.95 CD40 COL2A1 CSF1 HP LTA TNF
2 plasma membrane GO:0005886 9.93 CD163 CD40 CD80 CSF1 ITGAL LTA
3 extracellular region GO:0005576 9.92 CD163 CD40 COL2A1 CSF1 HP LTA
4 integral component of plasma membrane GO:0005887 9.8 CD163 CD40 MARCO TLR2 TLR4 TNF
5 external side of plasma membrane GO:0009897 9.35 CD163 CD40 CD80 TLR4 TNF
6 cell surface GO:0009986 9.23 CD40 CD80 ITGAL NOD2 TLR2 TLR4
7 membrane GO:0016020 10.18 CD163 CD40 CD80 CSF1 ITGAL LTA

Biological processes related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.98 CD80 CSF1 PTGS2 TNF TNFRSF1A
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 MARCO NOD2 TLR4 TNF
3 response to lipopolysaccharide GO:0032496 9.93 LTA PTGS2 TLR2 TLR4
4 defense response to bacterium GO:0042742 9.93 HP NOD2 TLR4 TNF TNFRSF1A
5 defense response GO:0006952 9.91 HP NOD2 TNF TNFRSF1A
6 activation of MAPK activity GO:0000187 9.88 NOD2 TLR4 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.87 LTA TLR2 TNF
8 response to organic substance GO:0010033 9.87 HP PTGS2 TNF
9 positive regulation of JNK cascade GO:0046330 9.86 NOD2 TLR4 TNF
10 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.83 TLR4 TNF TNFRSF1A
11 positive regulation of MAP kinase activity GO:0043406 9.83 CD40 NOD2 TNF
12 positive regulation of tumor necrosis factor production GO:0032760 9.82 NOD2 TLR2 TLR4
13 cellular response to mechanical stimulus GO:0071260 9.81 CD40 PTGS2 TLR4 TNFRSF1A
14 positive regulation of interferon-gamma production GO:0032729 9.8 LTA TLR4 TNF
15 positive regulation of inflammatory response GO:0050729 9.8 TLR2 TLR4 TNF TNFRSF1A
16 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.8 CD40 NOD2 TLR4 TNF TNFRSF1A
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 PTGS2 TLR4 TNF
18 regulation of inflammatory response GO:0050727 9.78 NOD2 PTGS2 TLR4 TNF
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TLR2 TLR4 TNF
20 tumor necrosis factor-mediated signaling pathway GO:0033209 9.76 CD40 LTA TNF TNFRSF1A
21 positive regulation of interleukin-12 production GO:0032735 9.73 CD40 TLR2 TLR4
22 prostaglandin metabolic process GO:0006693 9.72 PTGS2 TNFRSF1A
23 positive regulation of osteoclast differentiation GO:0045672 9.72 CSF1 TNF
24 positive regulation of interleukin-10 production GO:0032733 9.72 NOD2 TLR2 TLR4
25 cellular response to lipopolysaccharide GO:0071222 9.72 CD40 CD80 NOD2 TLR4 TNF
26 positive regulation of stress-activated MAPK cascade GO:0032874 9.71 NOD2 TLR4
27 microglial cell activation GO:0001774 9.71 TLR2 TNF
28 response to fatty acid GO:0070542 9.71 PTGS2 TLR2
29 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 NOD2 TLR4
30 positive regulation of glial cell proliferation GO:0060252 9.7 LTA TNF
31 negative regulation of growth of symbiont in host GO:0044130 9.7 LTA TNF
32 regulation of cytokine secretion GO:0050707 9.7 TLR2 TLR4
33 positive regulation of chemokine production GO:0032722 9.7 TLR2 TLR4 TNF
34 I-kappaB phosphorylation GO:0007252 9.69 TLR2 TLR4
35 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 TLR4
36 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR4 TNF
37 positive regulation of ceramide biosynthetic process GO:2000304 9.68 TNF TNFRSF1A
38 death-inducing signaling complex assembly GO:0071550 9.67 TNF TNFRSF1A
39 positive regulation of interleukin-6 production GO:0032755 9.67 NOD2 TLR2 TLR4 TNF
40 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF TNFRSF1A
41 positive regulation of fever generation GO:0031622 9.64 PTGS2 TNF
42 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.64 LTA TNF
43 regulation of immunoglobulin secretion GO:0051023 9.63 CD40 TNF
44 cytokine secretion involved in immune response GO:0002374 9.61 NOD2 TLR2
45 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 NOD2 TLR2 TLR4
46 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.58 TLR2 TLR4
47 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.57 LTA TNF
48 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.56 NOD2 TLR2 TLR4 TNF
49 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.55 CD40 NOD2 TLR2 TLR4 TNF
50 inflammatory response GO:0006954 9.28 CD163 CD40 CSF1 ITGAL PTGS2 TLR2

Molecular functions related to Spondylarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 9.16 NOD2 TLR2
2 signaling pattern recognition receptor activity GO:0008329 8.96 MARCO TLR2
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Spondylarthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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