Aliases & Classifications for Spondylarthropathy

MalaCards integrated aliases for Spondylarthropathy:

Name: Spondylarthropathy 52
Spondylarthropathies 54 71

Classifications:



External Ids:

UMLS 71 C0949691

Summaries for Spondylarthropathy

MalaCards based summary : Spondylarthropathy, also known as spondylarthropathies, is related to spondyloarthropathy and spondyloarthropathy 1, and has symptoms including sciatica An important gene associated with Spondylarthropathy is SPDA3 (Spondylarthropathy, Susceptibility To, 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Pamidronate and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and colon, and related phenotypes are cellular and hematopoietic system

Wikipedia : 74 Spondyloarthropathy or spondyloarthrosis refers to any joint disease of the vertebral column. As such,... more...

Related Diseases for Spondylarthropathy

Diseases related to Spondylarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 32.7 TNF SPDA3 LTA ITGAL
2 spondyloarthropathy 1 31.9 TNFRSF1A TNF TLR4 NOD2 CD163
3 spondylitis 31.2 TNF NOD2 LTA
4 reactive arthritis 30.5 TNF TLR4 TLR2 HP
5 synovitis 30.5 TNFRSF1A TNF COL2A1 CD163
6 arthropathy 30.4 TNF PTGS2 LTA COL2A1
7 uveitis 30.2 TNFRSF1A TNF NOD2 LTA
8 urethritis 30.0 TNF TLR4 TLR2
9 juvenile rheumatoid arthritis 30.0 TNFRSF1A TNF LTA
10 tenosynovitis 29.9 TNF NOD2
11 chlamydia 29.9 TNF TLR4 TLR2
12 hidradenitis suppurativa 29.8 TNF TLR4 NOD2 LTA
13 hidradenitis 29.8 TNF TLR4 NOD2 LTA
14 bone disease 29.8 TNF LTA CSF1 COL2A1
15 sarcoidosis 1 29.5 TNF NOD2 LTA CD80
16 ileitis 29.5 TNF TLR4 TLR2 NOD2
17 proteasome-associated autoinflammatory syndrome 1 29.4 TNF TLR4 TLR2 PTGS2
18 dysentery 29.3 TNF TLR4 TLR2 HP
19 psoriatic arthritis 29.2 TNFRSF1A TNF TLR4 TLR2 NOD2 LTA
20 bacterial infectious disease 29.0 TNF TLR4 TLR2 NOD2 CD80
21 crohn's disease 28.9 TNFRSF1A TNF TLR4 TLR2 NOD2 HP
22 osteoporosis 28.8 TNF TLR4 PTGS2 LTA CSF1 COL2A1
23 colitis 28.8 TNF TLR4 TLR2 PTGS2 NOD2
24 autoimmune disease 28.5 TNFRSF1A TNF LTA ITGAL CD80 CD40
25 bone inflammation disease 28.4 TNFRSF1A TNF TLR4 TLR2 PTGS2 COL2A1
26 psoriasis 28.1 TNFRSF1A TNF TLR2 NOD2 LTA ITGAL
27 immune deficiency disease 27.9 TNFRSF1A TNF TLR2 LTA ITGAL CD80
28 arthritis 27.1 TNFRSF1A TNF TLR4 TLR2 PTGS2 NOD2
29 inflammatory bowel disease 26.6 TNFRSF1A TNF TLR4 TLR2 PTGS2 NOD2
30 rheumatoid arthritis 26.5 TNFRSF1A TNF TLR4 TLR2 PTGS2 LTA
31 enthesitis-related juvenile idiopathic arthritis 11.2
32 inflammatory spondylopathy 10.8
33 enthesopathy 10.5
34 kashin-beck disease 10.4 TNF COL2A1
35 bone giant cell sarcoma 10.4 CSF1 CD163
36 plica syndrome 10.4
37 anaerobic pneumonia 10.4 TNF CD40
38 necrobiosis lipoidica 10.4 TNF CD163
39 metal allergy 10.4 TNF TLR4
40 streptococcal toxic-shock syndrome 10.4 TNF LTA
41 pulpitis 10.3 TNF TLR4 CD163
42 back pain 10.3
43 tympanosclerosis 10.3 TNF TLR4 COL2A1
44 stachybotrys chartarum 10.3 TNF CSF1
45 shwartzman phenomenon 10.3 TNF TLR4
46 null-cell leukemia 10.3 TNF LTA
47 chorioamnionitis 10.3 TNF TLR4 CD163
48 actinic prurigo 10.3 TNF ITGAL
49 amyloidosis 10.3
50 bronchopneumonia 10.3 TNF TLR4 HP

Graphical network of the top 20 diseases related to Spondylarthropathy:



Diseases related to Spondylarthropathy

Symptoms & Phenotypes for Spondylarthropathy

UMLS symptoms related to Spondylarthropathy:


sciatica

MGI Mouse Phenotypes related to Spondylarthropathy:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 CD163 CD80 COL2A1 CSF1 HP ITGAL
2 hematopoietic system MP:0005397 10.36 CD163 CD40 CD80 CSF1 HP ITGAL
3 immune system MP:0005387 10.35 CD163 CD40 CD80 COL2A1 CSF1 HP
4 homeostasis/metabolism MP:0005376 10.31 CD163 CD40 COL2A1 CSF1 HP ITGAL
5 cardiovascular system MP:0005385 10.26 CD163 COL2A1 CSF1 HP LTA PTGS2
6 endocrine/exocrine gland MP:0005379 10.13 CD40 CD80 CSF1 LTA PTGS2 TLR2
7 liver/biliary system MP:0005370 10.09 COL2A1 CSF1 HP LTA PTGS2 TLR2
8 digestive/alimentary MP:0005381 10.08 COL2A1 NOD2 PTGS2 TLR2 TLR4 TNF
9 adipose tissue MP:0005375 10.04 COL2A1 PTGS2 TLR2 TLR4 TNF TNFRSF1A
10 nervous system MP:0003631 10.02 CD40 CD80 COL2A1 CSF1 LTA PTGS2
11 muscle MP:0005369 9.95 CD163 CSF1 PTGS2 TLR2 TLR4 TNF
12 limbs/digits/tail MP:0005371 9.93 COL2A1 CSF1 LTA TLR4 TNF TNFRSF1A
13 neoplasm MP:0002006 9.91 HP ITGAL PTGS2 TLR2 TLR4 TNF
14 respiratory system MP:0005388 9.81 CD163 COL2A1 CSF1 LTA PTGS2 TLR2
15 renal/urinary system MP:0005367 9.8 CD40 COL2A1 HP PTGS2 TLR2 TLR4
16 skeleton MP:0005390 9.65 CD40 COL2A1 CSF1 LTA NOD2 PTGS2
17 vision/eye MP:0005391 9.23 CD163 COL2A1 CSF1 LTA PTGS2 TLR4

Drugs & Therapeutics for Spondylarthropathy

Drugs for Spondylarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pamidronate Approved Phase 4 40391-99-9 4674
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3
Etanercept Approved, Investigational Phase 4 185243-69-0
4
Adalimumab Approved Phase 4 331731-18-1 16219006
5
Infliximab Approved Phase 4 170277-31-3
6 Vaccines Phase 4
7 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
8 Cyclooxygenase 2 Inhibitors Phase 4
9 Cyclooxygenase Inhibitors Phase 4
10 Immunoglobulins Phase 4
11 Antibodies Phase 4
12 Antibodies, Monoclonal Phase 4
13 Gastrointestinal Agents Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Analgesics Phase 4
16 Anti-Inflammatory Agents Phase 4
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
19
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
20
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
21
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
22 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
23
Sulfasalazine Approved Phase 3 599-79-1 5353980 5359476
24
Hydroxychloroquine Approved Phase 3 118-42-3 3652
25 Ixekizumab Approved, Investigational Phase 3 1143503-69-8
26
tannic acid Approved Phase 3 1401-55-4
27
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
28
Certolizumab pegol Approved Phase 3 428863-50-7
29
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
30 Methylprednisolone Acetate Phase 2, Phase 3
31 Hormones Phase 2, Phase 3
32 Antineoplastic Agents, Hormonal Phase 2, Phase 3
33 Hormone Antagonists Phase 2, Phase 3
34 glucocorticoids Phase 2, Phase 3
35 Anti-Infective Agents Phase 3
36 Antiprotozoal Agents Phase 3
37 Antiparasitic Agents Phase 3
38 Antimalarials Phase 3
39 Sodium Pertechnetate Tc 99m Phase 3
40 Chelating Agents Phase 3
41 Immunoglobulin Fab Fragments Phase 3
42 Pharmaceutical Solutions Phase 2, Phase 3
43
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
44 Brodalumab Approved, Investigational Phase 2 1174395-19-7
45 abobotulinumtoxinA Phase 2
46 Cholinergic Agents Phase 2
47 Botulinum Toxins, Type A Phase 2
48 Neurotransmitter Agents Phase 2
49 Botulinum Toxins Phase 2
50 Antiemetics Phase 2

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 A Multicentre, Double-Blind, Placebo-Controlled, Randomized Study of Etanercept in the Treatment of Adults Patients With Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4 Etanercept
2 TNFalfa Blocking Treatment of Spondylarthropathies - A Danish Multicenter Study of New Methods for Better Monitoring and Prognostifying Patients With Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
3 Effects of Different Anti-rheumatic Treatments of Arthritis on Antibody Response Following Pneumococcal Vaccination Using Prevenar® Completed NCT00828997 Phase 4
4 Evaluation of Clinical Value of Standardized Protocol for Dose-reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Therapy: Open-label, Controlled, Randomized, Multicenter Trial. Completed NCT01604629 Phase 4 Reduced doses of anti-TNF;Stable doses of anti-TNF
5 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Randomized Controlled Trial Completed NCT01718951 Phase 4 golimumab;Pamidronate
6 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Results From MRI Finding Completed NCT03190603 Phase 4 Celecoxib
7 A Prospective Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 50mg etanercept;25mg etanercept;placebo
8 A Phase-IV, Multicenter, Noncomparative, Open-Label Study Evaluating the Safety and Efficacy of Golimumab (a Fully Human Anti-TNFα Monoclonal Antibody, Administered Subcutaneously) in the Treatment of Indian Patients With Active Spondyloarthropathy of Ankylosing Spondylitis or Psoriatic Arthritis Recruiting NCT03733925 Phase 4 Golimumab
9 Study of Peripheral Enthesitis With Ultra Sonography Doppler in Spondyloarthropathies Treated With Infliximab Terminated NCT00686894 Phase 4 Infliximab
10 Discontinuation of TNF-alpha Inhibitors in Spondylarthritis Patients With Low Disease Activity, and Re-initiation of Therapy if Disease Flares Terminated NCT00726804 Phase 4 Discontinuation of TNF-alpha inhibitor and re-starting it if flare-up in disease activity (etanercept or adalimumab)
11 Methotrexate in the Treatment of Axial Spondyloarthritis. A Randomized, Multicenter, Double-Blind, Placebo-Controlled Study. Withdrawn NCT00298012 Phase 4 Methotrexate
12 Threecenter Placebo Controlled Three Arm Trial in Patients With Active Ankylosing Spondylitis With Prednisolone Unknown status NCT00244166 Phase 2, Phase 3 prednisolone
13 Phase III Study of Human Bone Marrow-Derived Mesenchymal Stem Cells to Treat AS Unknown status NCT02809781 Phase 2, Phase 3 Etanercept
14 A Prospective Double Blind Placebo Controlled Trial of Combination Disease Modifying Antirheumatic Drugs (DMARDs) vs Monotherapy (Sulfasalazine) in Patients With Inflammatory Low Backache in Early Seronegative Spondylarthropathy Completed NCT01040195 Phase 3 Methotrexate, Hydroxychloroquine;Placebo
15 A Phase 3, Multicenter Study With a 36-Week Open-Label Period Followed by a Randomized Double-Blind Withdrawal Period From Week 36 to Week 104 to Evaluate the Long-Term Efficacy and Safety of Ixekizumab (LY2439821) 80 mg Every 2 Weeks in Biologic Disease-Modifying Antirheumatic Drug-Naive Patients With Active Psoriatic Arthritis Completed NCT02584855 Phase 3 Ixekizumab;Placebo
16 Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy and Safety of Certolizumab Pegol in Subjects With Active Axial Spondyloarthritis Completed NCT01087762 Phase 3
17 A Multicenter, Open-label (Part A) Followed by a Randomized, Double-blind, Parallel-group, Placebo Controlled Study (Part B) to Evaluate Maintenance of Remission in Subjects With Active Axial Spondyloarthritis (axSpA) Receiving Either Certolizumab Pegol 200 mg Q2W or 200 mg Q4W as Compared to Placebo Completed NCT02505542 Phase 3
18 Mechanism of Action Study of Anti-IL17 Treatment in Spondyloarthritis: Impact on Cellular and Molecular Pathways of Synovial Inflammation and Tissue Remodeling Completed NCT03358134 Phase 3 Secukinumab
19 Scintigraphic Detection of the Biodistribution of Tumor Necrosis Factor With a Radiolabeled Anti-TNFα in Patients With Active Rheumatoid Arthritis and Active Axial and Peripheral Spondyloarthritis Completed NCT01590966 Phase 3 administration of Cimzia®;Immunoscintigraphy with radiolabeled Cimzia®.
20 A Multicenter, Randomized, Double-Blind, Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis Completed NCT01808118 Phase 3
21 Efficacy, Safety, and Tolerability of Infliximab (Remicade; Schering-Plough) in Juvenile Spondyloarthropathies: a Three-Month, Randomized, Double-Blind, Placebo-Controlled Trial and 52-Week Open Extension. Completed NCT00591201 Phase 2, Phase 3 infliximab;Placebo
22 Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Efficacy and Safety of Certolizumab Pegol in Subjects With Active Axial Spondyloarthritis (axSpA) Without X-Ray Evidence of Ankylosing Spondylitis (AS) and Objective Signs of Inflammation Active, not recruiting NCT02552212 Phase 3
23 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate
24 Feasability Study on the Use of Botulinum Toxin A in Primary Adductor Tendinopathies Refractory to Medical Treatment Recruiting NCT03496649 Phase 2 Dysport 500 Unit Powder for Injection
25 A Randomized, Double-blinded, Placebo-controlled, Multiple-dose Study With an Open Label Extension to Evaluate the Safety and Efficacy of AMG 827 in Subjects With Psoriatic Arthritis. Terminated NCT01516957 Phase 2 AMG 827;Placebo;AMG 827;AMG 827
26 Intra-articular and Intravenous Infliximab in the Treatment of Resistant Seronegative Oligoarthritis of the Knee Terminated NCT01216631 Phase 2 methylprednisolone;Infliximab;Infliximab
27 Guide-Free Sacroiliac Injection in Spondyloarthropathies Unknown status NCT00829543 Early Phase 1
28 Presence of IBD Specific Antibodies (ASCA, ALCA, ACCA, AMCA) in the Sera of Patients With Spondyloarthropathy Unknown status NCT00517101
29 French Cohort on Outcome of Recent Undifferentiated Spondyloarthritis Unknown status NCT01648907
30 Feasibility of an Immersive Virtual Reality Based Biofeedback Intervention for Outpatients in Rheumatology: An Observational Cohort Study Unknown status NCT03459274
31 Frequency of Axial Spondyloarthropathy Among Patients Suffering From Fibromyalgia - Application of the ASAS Classification Criteria Unknown status NCT01167413
32 Prospective, International, Multi-centre Study on ASAS Classification Criteria for SpA Unknown status NCT00328068
33 Sarcopenia in Axial and Peripheral Spondyloarthropathies Completed NCT03319264
34 Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy in Patients With Uncertain Diagnosis Consulting for Clinical Symptoms Suggestive of Spondylarthropathy Completed NCT00794404
35 Prevalence of Small Bowel Inflammatory Crohn's Disease Lesions in Patients With Spondyloarthropathies (SpA): A Prospective Capsule Endoscopy-Based Study Completed NCT03064815
36 Systematic Descriptive Experimental Ultrasound Study of Entheses and Small Joints of Hands and Feet in Patients Presenting an Atypical Form of Psoriasis Completed NCT02899429
37 Observational Trial on the Value of Diagnostic Criteria in the Diagnosis of Spinal Spondyloarthropathies in Patients With Chronic Low Back Pain Completed NCT00726765
38 Safety Data on Etoricoxib From Swedish Registries of Spondyloarthropathy/Ankylosing Spondylitis Patients Completed NCT01327638 etoricoxib;Other COX-2 inhibitor;nsNSAIDs
39 Physiotherapy-led Outpatient Clinic for Patients With Spondyloarthritis Completed NCT02098694
40 Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey. Programme de Recherche du Groupe Qualité de Vie, de la Section Epidémiologie et de la Section Arthrose de la Société Française de Rhumatologie Completed NCT01400529
41 C.O.R.P.U.S. : Observational Cohort of Active Rheumatoid Arthritis, Spondylarthropathy and Idiopathic Juvenile Arthritis in France Completed NCT02886689 TNF-alpha antagonist and other biotherapy
42 Increasing Physical Activity in Ankylosing Spondylitis (INPACT-AS): a Randomised Controlled Trial Completed NCT02374502
43 Performance of Referral Recommendations in Patients With Chronic Back Pain and Suspected Axial Spondyloarthritis Completed NCT00383617
44 Non-Interventional Observational Study on Patient Satisfaction With the Benepali® Pre-Filled Pen Completed NCT03327454
45 Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study Completed NCT00056719
46 The Characterization of Small Bowel and Colonic Involvement in Patients With Seronegative Spondyloarthritides Completed NCT00768950
47 Do Inflammatory Arthritis Inpatients Receiving Group Music Therapy Improve Pain Compared to Music Listening Over the 4 Weeks Using a Randomised Control Trial? Completed NCT02436785
48 Faecal Analyses in Spondyloarthritis Therapy: A Prospective Observational Study of the Intestinal Microbiome in Patients With Spondyloarthropathy Receiving TNF-inhibition. Recruiting NCT03839862 TNF-inhibition
49 Cartography and Quantitative Characterization of Achilles Tendon Fibrocartilage by TE = 0ms Imaging at3T MRI Recruiting NCT03287596
50 Clinical Description of Spondylarthritis and Validation of Assessment of SpondyloArthritis International Society (ASAS) Criteria in West Indian Patients Seen in the Routine Consultation of Rheumatology. Recruiting NCT03564743

Search NIH Clinical Center for Spondylarthropathy

Genetic Tests for Spondylarthropathy

Anatomical Context for Spondylarthropathy

MalaCards organs/tissues related to Spondylarthropathy:

40
Bone, T Cells, Colon, Neutrophil, Spinal Cord, Eye, Skin

Publications for Spondylarthropathy

Articles related to Spondylarthropathy:

(show top 50) (show all 800)
# Title Authors PMID Year
1
Diagnostic performance of plain radiography for sacroiliitis in patients with suspected axial spondyloarthritis: a systematic review and meta-analysis. 61
32536262 2020
2
Clinical manifestations, disease activity and disease burden of radiographic versus non-radiographic axial spondyloarthritis over 5 years of follow-up in the DESIR cohort. 61
31784451 2020
3
Spinal Radiographic Progression in Early Axial Spondyloarthritis: Five-Year Results From the DESIR Cohort. 61
30354022 2019
4
[Biologics in rheumatology]. 61
31485714 2019
5
Evaluation of the predictive validity of the ASAS axial spondyloarthritis criteria in the DESIR cohort. 61
30873948 2019
6
Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study. 61
31335881 2019
7
Low incidence of vertebral fractures in early spondyloarthritis: 5-year prospective data of the DESIR cohort. 61
30389692 2019
8
A patient with spondylarthropathy treated with TNF-α inhibitors presenting with clinical findings suspicious of metastatic cancer disease. 61
30376121 2018
9
A patient with spondylarthropathy treated with TNF-α inhibitors presenting with clinical findings suspicious of metastatic cancer disease. 61
30137507 2018
10
Panorama of inflammatory arthropathies in rheumatologic consultations in Northern Togo. 61
30270840 2018
11
Detection of Crohn Disease in Patients with Spondyloarthropathy: The SpACE Capsule Study. 61
29449505 2018
12
Can power Doppler ultrasound of the entheses help in classifying recent axial spondyloarthritis? Data from the DESIR cohort. 61
30167327 2018
13
Classification criteria versus physician's opinion for considering a patient with inflammatory back pain as suffering from spondyloarthritis. 61
28214597 2018
14
Adherence to Antitumor Necrosis Factor Use Recommendations in Spondyloarthritis: Measurement and Effect in the DESIR Cohort. 61
28668809 2017
15
The yield of a positive MRI of the spine as imaging criterion in the ASAS classification criteria for axial spondyloarthritis: results from the SPACE and DESIR cohorts. 61
28663306 2017
16
Hidradenitis suppurativa 61
30512774 2017
17
[Musculoskeletal manifestations of sarcoidosis]. 61
28488045 2017
18
The danger from within: alarmins in arthritis. 61
27733758 2016
19
Clinical and Imaging Signs of Spondyloarthritis in First-Degree Relatives of HLA-B27-Positive Ankylosing Spondylitis Patients: The Pre-Spondyloarthritis (Pre-SpA) Cohort Study. 61
27214232 2016
20
Analysis and performance of various classification criteria sets in a Colombian cohort of patients with spondyloarthritis. 61
26791876 2016
21
Differential diagnosis of a fused wrist with a partially destroyed capitate from Kazakhstan (1st-3rd century AD). 61
29539520 2016
22
[Spondylarthropathies in 2015]. 61
27089635 2016
23
[Skin symptoms of psoriasis associated with spondylarthropathies]. 61
27089637 2016
24
[Spondylarthropathies: conventional treatments and anti-TNF]. 61
27089640 2016
25
Factors associated with a bad functional prognosis in early inflammatory back pain: results from the DESIR cohort. 61
26870394 2016
26
Responsiveness of a simple RAPID-3-like index compared to disease-specific BASDAI and ASDAS indices in patients with axial spondyloarthritis. 61
27486525 2016
27
Skeletal indicators of reactive arthritis: A case study comparison to other skeletal conditions, such as rheumatoid arthritis, ankylosing spondylitis, ankylosing sero-negative SpA, and DISH. 61
28802971 2015
28
Relationship of Psoriatic Arthritis to Other Spondyloarthritides. 61
26523053 2015
29
Achilles tendinitis in systemic lupus erythematosus: search for an associated inflammatory disease. 61
25761656 2015
30
Brief Report: Nonsteroidal Antiinflammatory Drug-Sparing Effect of Tumor Necrosis Factor Inhibitors in Early Axial Spondyloarthritis: Results From the DESIR Cohort. 61
26109532 2015
31
Summary of Sensitivity and Specificity for Psoriatic Arthritis in a South African Cohort according to Classification Criteria. 61
25877500 2015
32
The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine immunization and subsequent pneumococcal infection in chronic arthritis patients. 61
25986458 2015
33
Importance of intestinal microenvironment in development of arthritis. A systematic review. 61
25407648 2015
34
Cardiovascular and selected comorbidities in early arthritis and early spondyloarthritis, a comparative study: results from the ESPOIR and DESIR cohorts. 61
26535145 2015
35
[Sarcoidosis after adalimumab treatment in inflammatory rheumatic diseases: a report of two cases and literature review]. 61
25534463 2015
36
The risk of pneumococcal infections after immunization with pneumococcal conjugate vaccine compared to non-vaccinated inflammatory arthritis patients. 61
25656734 2015
37
Immune cell transcript modules reveal leukocyte heterogeneity in synovial biopsies of seronegative spondylarthropathy patients. 61
25526985 2014
38
Early tumor necrosis factor α antagonist therapy in everyday practice for inflammatory back pain suggesting axial spondyloarthritis: results from a prospective multicenter french cohort. 61
24664935 2014
39
Agreement between clinical practice and trained central reading in reading of sacroiliac joints on plain pelvic radiographs. Results from the DESIR cohort. 61
24909765 2014
40
Evaluation of Assessment of Spondyloarthritis International Society classification criteria for axial spondyloarthritis in Chinese patients with chronic back pain: results of a 2-year follow-up study. 61
24912101 2014
41
Effectiveness of tumor necrosis factor α blockers in early axial spondyloarthritis: data from the DESIR cohort. 61
24623678 2014
42
Neurological adverse events in patients receiving anti-TNF therapy: a prospective imaging and electrophysiological study. 61
24938855 2014
43
Hidradenitis suppurrativa (acne inversa) as a systemic disease. 61
24767187 2014
44
Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis. 61
24690195 2014
45
Impact of anti-rheumatic treatment on immunogenicity of pandemic H1N1 influenza vaccine in patients with arthritis. 61
24383620 2014
46
Osteoporosis and osteoarthritis, rheumatoid arthritis and spondylarthropathies. 61
24085651 2013
47
Imaging in rheumatology: reconciling radiology and rheumatology. 61
24127271 2013
48
Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis. 61
24286269 2013
49
Increase in bone density in patients with spondyloarthritis during anti-tumor necrosis factor therapy: 6-year followup study. 61
23950191 2013
50
Factors associated with radiographic lesions in early axial spondyloarthritis. Results from the DESIR cohort. 61
23764945 2013

Variations for Spondylarthropathy

Expression for Spondylarthropathy

Search GEO for disease gene expression data for Spondylarthropathy.

Pathways for Spondylarthropathy

Pathways related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 TNFRSF1A TNF TLR4 TLR2 PTGS2 NOD2
2
Show member pathways
13.76 TNFRSF1A TNF PTGS2 LTA ITGAL CSF1
3
Show member pathways
13.62 TNFRSF1A TNF TLR4 PTGS2 LTA CSF1
4
Show member pathways
13.31 TNFRSF1A TNF PTGS2 NOD2 LTA CSF1
5
Show member pathways
13.28 TNFRSF1A TNF TLR4 TLR2 LTA ITGAL
6
Show member pathways
13.24 TNFRSF1A TNF LTA CSF1 CD80 CD40
7
Show member pathways
13.01 TNFRSF1A TNF TLR4 TLR2 CD80 CD40
8
Show member pathways
12.93 TNFRSF1A TNF TLR4 TLR2 PTGS2 CSF1
9
Show member pathways
12.88 TNFRSF1A TNF TLR4 TLR2 PTGS2
10
Show member pathways
12.81 TNF LTA ITGAL CD80 CD40
11
Show member pathways
12.79 TNFRSF1A TNF TLR4 TLR2 ITGAL CD40
12
Show member pathways
12.68 TNF TLR4 TLR2 PTGS2 NOD2
13
Show member pathways
12.66 TNFRSF1A TNF TLR4 TLR2 LTA CD40
14
Show member pathways
12.6 TNFRSF1A TNF LTA CD40
15
Show member pathways
12.54 TNF TLR4 TLR2 NOD2
16 12.51 TNFRSF1A TNF TLR2 PTGS2
17
Show member pathways
12.5 TNFRSF1A TNF TLR4 TLR2 LTA CD40
18 12.31 TNFRSF1A TNF LTA ITGAL CD40
19
Show member pathways
12.3 TNFRSF1A TNF LTA CSF1
20 12.27 TNFRSF1A TNF TLR4 TLR2
21 12.19 TNFRSF1A TNF TLR4 TLR2 NOD2
22 12.14 TNFRSF1A TNF TLR4 TLR2 PTGS2
23
Show member pathways
12.12 TNFRSF1A TNF TLR4 TLR2 PTGS2 CD40
24 12 TNF TLR4 PTGS2 COL2A1
25 11.9 TNF ITGAL CSF1 CD80 CD163
26
Show member pathways
11.89 MARCO HP CD163
27 11.87 TNF TLR4 TLR2
28 11.87 TNFRSF1A TNF TLR4
29
Show member pathways
11.83 TNF TLR4 TLR2 LTA CD80
30
Show member pathways
11.82 TLR4 TLR2 CD80
31 11.82 TLR4 TLR2 MARCO ITGAL
32
Show member pathways
11.8 TNFRSF1A TNF LTA CD40
33 11.72 TNF CSF1 CD163
34
Show member pathways
11.71 TNFRSF1A TNF CD40
35 11.68 TNFRSF1A TNF PTGS2 NOD2 LTA CSF1
36
Show member pathways
11.64 TNFRSF1A TNF PTGS2
37 11.59 TNF TLR4 TLR2
38 11.54 TNFRSF1A TNF TLR4 LTA
39
Show member pathways
11.53 TNFRSF1A TNF LTA
40 11.45 TNFRSF1A TNF TLR4 PTGS2 LTA CD40
41 11.44 TNF TLR4 TLR2 CSF1
42 11.42 TNF TLR4 TLR2 ITGAL CD40
43 11.34 TNFRSF1A TNF PTGS2 CSF1 CD80
44 11.33 TNFRSF1A CD80 CD40
45 11.31 TLR4 MARCO CD40
46 11.15 TNFRSF1A TNF NOD2
47 11.07 TNF TLR4 TLR2 ITGAL CSF1 CD80
48 11 TNF LTA ITGAL CSF1 COL2A1 CD80
49 10.9 TNF CSF1

GO Terms for Spondylarthropathy

Cellular components related to Spondylarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 TNFRSF1A TNF TLR4 TLR2 NOD2 MARCO
2 extracellular region GO:0005576 9.92 TNFRSF1A TNF LTA HP CSF1 COL2A1
3 integral component of plasma membrane GO:0005887 9.8 TNFRSF1A TNF TLR4 TLR2 MARCO CD40
4 external side of plasma membrane GO:0009897 9.35 TNF TLR4 CD80 CD40 CD163
5 cell surface GO:0009986 9.23 TNFRSF1A TNF TLR4 TLR2 NOD2 ITGAL

Biological processes related to Spondylarthropathy according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.19 TNFRSF1A TNF TLR4 TLR2 NOD2 CD40
2 innate immune response GO:0045087 10.1 TLR4 TLR2 NOD2 MARCO CSF1
3 immune response GO:0006955 10.07 TNF TLR4 TLR2 LTA CD80
4 immune system process GO:0002376 10.04 TLR4 TLR2 NOD2 MARCO HP CSF1
5 cytokine-mediated signaling pathway GO:0019221 10 TNFRSF1A TNF PTGS2 CSF1 CD80
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 TNF TLR4 NOD2 MARCO
7 defense response to bacterium GO:0042742 9.96 TNFRSF1A TNF TLR4 NOD2 HP
8 response to lipopolysaccharide GO:0032496 9.95 TLR4 TLR2 PTGS2 LTA
9 defense response GO:0006952 9.93 TNFRSF1A TNF NOD2 HP
10 tumor necrosis factor-mediated signaling pathway GO:0033209 9.91 TNFRSF1A TNF LTA CD40
11 activation of MAPK activity GO:0000187 9.89 TNF TLR4 NOD2
12 defense response to Gram-positive bacterium GO:0050830 9.88 TNF TLR2 LTA
13 response to organic substance GO:0010033 9.87 TNF PTGS2 HP
14 positive regulation of JNK cascade GO:0046330 9.87 TNF TLR4 NOD2
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 TNFRSF1A TNF CD40
16 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.85 TNFRSF1A TNF TLR4
17 positive regulation of MAP kinase activity GO:0043406 9.84 TNF NOD2 CD40
18 positive regulation of tumor necrosis factor production GO:0032760 9.84 TLR4 TLR2 NOD2
19 positive regulation of inflammatory response GO:0050729 9.84 TNFRSF1A TNF TLR4 TLR2
20 regulation of inflammatory response GO:0050727 9.83 TNF TLR4 PTGS2 NOD2
21 positive regulation of interferon-gamma production GO:0032729 9.82 TNF TLR4 LTA
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 TNF TLR4 PTGS2
23 positive regulation of interleukin-6 secretion GO:2000778 9.8 TNF TLR4 TLR2
24 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.8 TNFRSF1A TNF TLR4 NOD2 CD40
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.79 TNF TLR4 TLR2
26 cellular response to mechanical stimulus GO:0071260 9.78 TNFRSF1A TLR4 PTGS2 CD40
27 cellular response to lipopolysaccharide GO:0071222 9.77 TNF TLR4 NOD2 CD80 CD40
28 positive regulation of interleukin-12 production GO:0032735 9.75 TLR4 TLR2 CD40
29 positive regulation of interleukin-10 production GO:0032733 9.74 TLR4 TLR2 NOD2
30 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.72 TNF TLR4 NOD2
31 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TNF TLR4
32 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.7 TNF TLR4
33 positive regulation of ceramide biosynthetic process GO:2000304 9.7 TNFRSF1A TNF
34 I-kappaB phosphorylation GO:0007252 9.7 TLR4 TLR2
35 cellular response to lipoteichoic acid GO:0071223 9.69 TLR4 TLR2
36 positive regulation of chemokine production GO:0032722 9.69 TNF TLR4 TLR2
37 regulation of establishment of endothelial barrier GO:1903140 9.68 TNFRSF1A TNF
38 death-inducing signaling complex assembly GO:0071550 9.68 TNFRSF1A TNF
39 regulation of immunoglobulin secretion GO:0051023 9.66 TNF CD40
40 positive regulation of fever generation GO:0031622 9.65 TNF PTGS2
41 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.65 TNF LTA
42 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 TNF TLR4 TLR2 NOD2 CD40
43 cytokine secretion involved in immune response GO:0002374 9.64 TLR2 NOD2
44 positive regulation of interleukin-8 secretion GO:2000484 9.63 TNF TLR4 TLR2
45 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.62 TNF TLR4 TLR2 NOD2
46 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 TLR4 TLR2 NOD2
47 positive regulation of matrix metallopeptidase secretion GO:1904466 9.6 TLR4 TLR2
48 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.59 TLR4 TLR2
49 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.58 TNF LTA
50 positive regulation of interleukin-6 production GO:0032755 9.46 TNF TLR4 TLR2 NOD2

Molecular functions related to Spondylarthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 9.37 TLR2 NOD2
2 amyloid-beta binding GO:0001540 9.33 TLR4 TLR2 MARCO
3 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.32 TLR4 TLR2
4 NAD(P)+ nucleosidase activity GO:0050135 9.26 TLR4 TLR2
5 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2
6 pattern recognition receptor activity GO:0038187 8.8 TLR2 NOD2 MARCO

Sources for Spondylarthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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