Aliases & Classifications for Spondylitis

MalaCards integrated aliases for Spondylitis:

Name: Spondylitis 12 76 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6590
ICD10 33 M46
ICD9CM 35 720.8 720.89
SNOMED-CT 68 202651004 202653001

Summaries for Spondylitis

MalaCards based summary : Spondylitis is related to spondyloarthropathy 1 and reactive arthritis, and has symptoms including sciatica An important gene associated with Spondylitis is MICA (MHC Class I Polypeptide-Related Sequence A), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Naproxen and Isoniazid have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

Related Diseases for Spondylitis

Diseases related to Spondylitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 405)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 31.1 CD40LG CRP HLA-B IL17A NOD2 TNF
2 reactive arthritis 30.8 CRP HLA-B IL6 TNF
3 spondylarthropathy 30.8 LTA TNF
4 uveitis 30.6 HLA-B IL17A NOD2 TNF
5 arthropathy 30.3 CRP MICA TNF
6 complex regional pain syndrome 30.3 HLA-B IL6 TNF
7 familial mediterranean fever 30.2 CRP NOD2 TNF
8 endocarditis 30.2 CRP IL6 TNF
9 arteries, anomalies of 30.2 CRP IL6 TNF
10 ischemic heart disease 30.2 CRP IL6 TNF
11 transverse myelitis 30.1 IL17A IL6 TNF
12 adult-onset still's disease 30.1 CRP IL6 TNF
13 myelitis 30.1 IL17A IL6 TNF
14 synovitis 30.1 CRP IL6 TNF
15 pyelonephritis 30.1 CRP IL6 TNF
16 spondyloarthropathy 30.0 HLA-B HLA-C IL17A IL6 TNF
17 granulomatous dermatitis 29.9 NOD2 TNF
18 arthritis 29.9 IL17A IL6 LTA MICA TNF TNFRSF1B
19 periodontitis 29.8 CRP IL17A IL6 TNF
20 cellulitis 29.8 CHI3L1 CRP TNF
21 hidradenitis suppurativa 29.6 IL17A NOD2 TNF
22 hidradenitis 29.6 IL17A NOD2 TNF
23 iritis 29.6 CD40LG HLA-B TNFRSF1B
24 mixed connective tissue disease 29.6 CD40LG IL6 TNF
25 brucellosis 29.5 CD40LG CRP IL6 TNF
26 rheumatic disease 29.5 CD40LG CRP HLA-B TNF
27 pneumonia 29.4 CD40LG CRP IL6 TNF
28 temporal arteritis 29.4 CD40LG CRP IL6
29 ulcerative colitis 29.3 CRP IL23R IL6 NOD2 TNF
30 purpura 29.3 CD40LG CRP TNF
31 connective tissue disease 29.3 CD40LG IL6 MICA TNF
32 colitis 29.2 IL17A IL23R IL6 NOD2 TNF
33 meningitis 29.1 CD40LG CRP IL6 TNF
34 bronchiolitis 28.9 CD40LG IL6 TNF
35 vasculitis 28.9 CD40LG CRP TNF TNFRSF1B
36 acquired immunodeficiency syndrome 28.9 CD40LG HLA-B IL6 TNF
37 q fever 28.9 CD40LG NOD2 TNF
38 crohn's disease 28.8 CRP IL23R IL6 NOD2 TNF TNFRSF1B
39 chlamydia 28.7 CD40LG CRP IL6 TNF
40 psoriatic arthritis 28.3 CRP HLA-B HLA-C IL17A IL23R IL6
41 demyelinating disease 28.2 CD40LG IL17A TNF
42 takayasu arteritis 28.1 CD40LG CRP HLA-B IL6 MICA TNF
43 psoriasis 28.0 HLA-C IL17A IL23R IL6 LTA MICA
44 autoimmune disease 27.5 CD40LG HLA-B IL17A IL6 TNF TNFRSF1B
45 rheumatoid arthritis 27.4 CD40LG CHI3L1 CRP HLA-B IL17A IL6
46 systemic lupus erythematosus 27.1 CD40LG CRP IL17A IL6 LTA TNF
47 inflammatory bowel disease 26.3 CHI3L1 CRP HLA-B IL17A IL23R IL6
48 gonococcal spondylitis 12.0
49 spinal disease 11.2
50 inflammatory spondylopathy 10.9

Comorbidity relations with Spondylitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to Spondylitis

Symptoms & Phenotypes for Spondylitis

UMLS symptoms related to Spondylitis:


sciatica

GenomeRNAi Phenotypes related to Spondylitis according to GeneCards Suite gene sharing:

26 (show all 29)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.23 HLA-B HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.23 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.23 HLA-B HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.23 HLA-B HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.23 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.23 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.23 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.23 HLA-B HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.23 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.23 NOD2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.23 NOD2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.23 HLA-B HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.23 HLA-B MICA NOD2 HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.23 NOD2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.23 NOD2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.23 HLA-C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.23 NOD2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.23 HLA-B HLA-C
19 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.23 NOD2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.23 NOD2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.23 MICA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.23 HLA-C
23 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.23 MICA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.23 HLA-B HLA-C
25 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.23 HLA-B HLA-C
26 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.23 MICA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.23 HLA-C
28 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 IL17A CD40LG LTA NOD2 SNAPC4 TNF
29 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 IL17A CD40LG LTA NOD2 SNAPC4 TNF

MGI Mouse Phenotypes related to Spondylitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 IL23R IL6 LTA NOD2 TAP1 TAP2
2 immune system MP:0005387 9.8 IL6 LTA NOD2 TAP1 TAP2 ANTXR2
3 skeleton MP:0005390 9.28 IL6 LTA NOD2 SNAPC4 SOST TNF

Drugs & Therapeutics for Spondylitis

Drugs for Spondylitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 266)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 1302 156391
2
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
3
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
4
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
5
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
6
Rifampicin Approved Phase 4,Phase 3 13292-46-1 5458213 5381226
7
Ethambutol Approved Phase 4 74-55-5 3279 14052
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
9
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
10
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
11
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 185243-69-0
12
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
13
Adalimumab Approved Phase 4,Phase 2,Phase 3,Not Applicable 331731-18-1 16219006
14
Pamidronate Approved Phase 4,Phase 1,Phase 2 40391-99-9 4674
15
Hydroxychloroquine Approved Phase 4,Phase 3 118-42-3 3652
16
Menthol Approved Phase 4,Phase 3,Not Applicable 2216-51-5 16666
17
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
18
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
19
Acetaminophen Approved Phase 4,Early Phase 1,Not Applicable 103-90-2 1983
20
Aceclofenac Approved, Investigational Phase 4 89796-99-6
21
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
22
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
24 beta-endorphin Phase 4
25 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
26 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Adrenocorticotropic Hormone Phase 4
28 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
29 Natriuretic Agents Phase 4
30 Natriuretic Peptide, Brain Phase 4
31 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3,Phase 1,Not Applicable
32 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
34 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 3
35 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Vaccines Phase 4,Phase 2
40 Antacids Phase 4,Phase 3,Phase 1
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
43 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
44 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
46 Hypolipidemic Agents Phase 4,Not Applicable
47 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 635)
# Name Status NCT ID Phase Drugs
1 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
2 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
3 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
4 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
5 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
6 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
7 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
8 Treatment of Axial Spondyloarthritis by Recombinant Human Tumor Necrosis Factor-α Receptor Ⅱ IgG Fc Fusion Protein Unknown status NCT02364479 Phase 4 etanercept;etanercept (half dose);placebo
9 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
10 The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis Unknown status NCT02477852 Phase 4 Isoniazid;Rifampicin;Ethambutol;Pyrazinamide
11 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
12 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
13 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
14 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
15 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
16 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
17 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
18 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
19 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
20 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
21 Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Active Ankylosing Spondylitis Completed NCT01934933 Phase 4 celebrex;Enbrel;Enbrel plus Celebrex
22 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
23 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
24 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
25 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
26 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
27 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
28 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
29 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
30 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
31 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
32 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
33 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
34 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
35 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
36 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
37 Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Completed NCT01604629 Phase 4 Reduced doses of anti-TNF;Stable doses of anti-TNF
38 Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis Completed NCT01029847 Phase 4 Adalimumab;Placebo
39 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4 golimumab;Pamidronate
40 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Completed NCT03190603 Phase 4 Celecoxib
41 Serum Creatinine Change / Renal Adverse Effect With Use of Non-steroidal Painkillers in Axial Spondyloarthritis Patients Completed NCT03582332 Phase 4 Indomethacin SR, 75 Mg Oral Capsule, Extended Release;Indomethacin 25 Mg Oral Capsule;Etoricoxib 90 mg;Etoricoxib 60 mg
42 A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis Completed NCT01298531 Phase 4 etanercept;etanercept;placebo
43 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
44 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
45 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4 Etanercept
46 HUmira in Psoriatic Arthritis Completed NCT01465438 Phase 4 Adalimumab
47 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
48 Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis Completed NCT00245960 Phase 4 etanercept
49 Prevalence of Psoriatic Arthritis in Adults With Psoriasis: An Estimate From Dermatology Practice Completed NCT01147874 Phase 4
50 Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis Completed NCT00432406 Phase 4 Infliximab;Etanercept

Search NIH Clinical Center for Spondylitis

Genetic Tests for Spondylitis

Anatomical Context for Spondylitis

MalaCards organs/tissues related to Spondylitis:

41
Bone, Testes, T Cells, Endothelial, Heart, B Cells, Skin

Publications for Spondylitis

Articles related to Spondylitis:

(show top 50) (show all 1789)
# Title Authors Year
1
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease. ( 29490353 )
2018
2
Concomitant mycotic abdominal aortic aneurysm and lumbartuberculous spondylitis with cauda equina syndrome: a rare condition - a case report and literature review. ( 29479482 )
2018
3
Ankylosing spondylitis and axial spondyloarthritis: recent insights and impact of new classification criteria. ( 29942364 )
2018
4
Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study. ( 29945918 )
2018
5
Q fever spondylitis: 2 cases report. ( 29887174 )
2018
6
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
7
Differences in carotid atherosclerosis between patients with ankylosing spondylitis treated with tumor necrosis factor-I+ antagonists and healthy matched controls. ( 29979389 )
2018
8
Does the preoperative lumbar sagittal profile affect the selection of osteotomy level in pedicle subtraction osteotomy for thoracolumbar kyphosis secondary to ankylosing spondylitis? ( 29966933 )
2018
9
Prevalence and factors associated with disturbed sleep in outpatients with ankylosing spondylitis. ( 29971585 )
2018
10
Characterization of Patients With Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis in the US-Based Corrona Registry. ( 29409123 )
2018
11
Associations Between Cardiorespiratory Fitness and Arterial Stiffness in Ankylosing Spondylitis: A Cross-sectional Study. ( 29961684 )
2018
12
Biomechanical properties of low back myofascial tissue in younger adult ankylosing spondylitis patients and matched healthy control subjects. ( 29936315 )
2018
13
Safety and Efficacy of Golimumab Administered Intravenously in Adults with Ankylosing Spondylitis: Results through Week 28 of the GO-ALIVE Study. ( 29419454 )
2018
14
Atherogenic index of plasma: a useful marker for subclinical atherosclerosis in ankylosing spondylitis : AIP associate with cIMT in AS. ( 29435680 )
2018
15
Coexistence of Ankylosing Spondylitis and Myotonic Dystrophy: Camptocormia or Thoracic Ankylosis. ( 29465620 )
2018
16
Identification of ANKDD1B variants in an ankylosing spondylitis pedigree and a sporadic patient. ( 29976160 )
2018
17
A differential expression network method identifies ankylosing spondylitis-related genes. ( 29970661 )
2018
18
Ankylosing Spondylitis Treatment after First Anti-TNF Drug Failure. ( 29431309 )
2018
19
TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes. ( 29940800 )
2018
20
Increased Rates of Both Knee and Hip Arthroplasties in Older Patients with Ankylosing Spondylitis. ( 29961693 )
2018
21
Ankylosing spondylitis kyphosis surgical correction postoperative evaluation via SRS-22 domain investigation. ( 29316959 )
2018
22
Stability of fatigue, pain, patient global assessment and the Bath Ankylosing Spondylitis Functional Index (BASFI) in spondyloarthropathy patients with stable disease according to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). ( 29299630 )
2018
23
TNF-I+ level affects etanercept clearance: TNF-I+ concentration as a new correction factor of allometric scaling to predict individual etanercept clearances in patients with ankylosing spondylitis. ( 29436715 )
2018
24
Hepatosplenic T-Cell Lymphoma Arising in a Patient Treated With Tumor Necrosis Factor-I+ Inhibitors for Ankylosing Spondylitis. ( 29933321 )
2018
25
Pulmonary Sarcoidosis following Etanercept Treatment for Ankylosing Spondylitis: A Case Report and Review of the Literature. ( 29610700 )
2018
26
Using Self-Reported Patient Experiences to Understand Patient Burden: Learnings from Digital Patient Communities in Ankylosing Spondylitis. ( 29450863 )
2018
27
Association of Crohn's disease-related chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and faecal calprotectin. ( 29967744 )
2018
28
Assessment of effectiveness and safety of biosimilar infliximab (CT-P13) in a real-life setting for treatment of patients with active rheumatoid arthritis or ankylosing spondylitis. ( 29439591 )
2018
29
Bacille Calmette-GuAcrin (BCG) spondylitis with adjacent mycotic aortic aneurysm after intravesical BCG therapy: a case report and literature review. ( 29954321 )
2018
30
A case of ankylosing spondylitis with concurrent Takayasu arteritis. ( 29690806 )
2018
31
The efficiency of inspiratory muscle training in patients with ankylosing spondylitis. ( 29943207 )
2018
32
Screening for key genes and transcription factors in ankylosing spondylitis by RNA-Seq. ( 29434723 )
2018
33
Association of polymorphisms in ERAP1 and risk of ankylosing spondylitis in a Chinese population. ( 29278768 )
2018
34
MMP-2 silencing reduces the osteogenic transformation of fibroblasts by inhibiting the activation of the BMP/Smad pathway in ankylosing spondylitis. ( 29435070 )
2018
35
A retrospective study of transcutaneous electrical nerve stimulation for chronic pain following ankylosing spondylitis. ( 29979392 )
2018
36
Immune cells involved in the pathogenesis of ankylosing spondylitis. ( 29428668 )
2018
37
Treatment patterns among patients with rheumatic disease (rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated arthritis (UnA)) treated with subcutaneous TNF inhibitors. ( 29667098 )
2018
38
Discrimination of pyogenic spondylitis from brucellar spondylitis on MRI. ( 29952971 )
2018
39
Bickerstaff brainstem encephalitis in a patient with ankylosing spondylitis on tumour necrosis factor-alpha inhibitor. ( 29465358 )
2018
40
Secukinumab in pregnancy: outcomes in psoriasis, psoriatic arthritis and ankylosing spondylitis from the global safety database. ( 29927479 )
2018
41
Red Blood Cell Distribution Width in Rheumatoid Arthritis, Ankylosing Spondylitis and Osteoarthritis: True Inflammatory Index or Effect of Anemia? ( 29970432 )
2018
42
Bone formation in ankylosing spondylitis during anti-tumour necrosis factor therapy imaged by 18F-fluoride positron emission tomography. ( 29415219 )
2018
43
Complex role of IL-23R polymorphisms on ankylosing spondylitis: a meta-analysis. ( 29944013 )
2018
44
Tuberculous Aortitis Associated With Pleuritis and Spondylitis. ( 29398471 )
2018
45
The role of gut microbiota and IL-23/IL-17 pathway in ankylosing spondylitis immunopathogenesis: New insights and updates. ( 29409751 )
2018
46
Response to Tumor Necrosis Factor Inhibition in Male and Female Patients with Ankylosing Spondylitis: Data from a Swiss Cohort. ( 29449504 )
2018
47
Comorbidity, disability, and healthcare expenditure of ankylosing spondylitis in Korea: A population-based study. ( 29420599 )
2018
48
The association of HLA-B27 and Klebsiella pneumoniae in ankylosing spondylitis: A systematic review. ( 29438717 )
2018
49
Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitis. ( 29741584 )
2018
50
Diffusion-weighted Imaging Is a Sensitive and Specific Magnetic Resonance Sequence in the Diagnosis of Ankylosing Spondylitis. ( 29449501 )
2018

Variations for Spondylitis

Expression for Spondylitis

Search GEO for disease gene expression data for Spondylitis.

Pathways for Spondylitis

Pathways related to Spondylitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CD40LG CHI3L1 CRP ERAP1 ERAP2 HLA-B
2
Show member pathways
13.4 CD40LG ERAP1 ERAP2 HLA-B HLA-C MICA
3
Show member pathways
13.25 CD40LG IL17A IL23R IL6 LTA TNF
4
Show member pathways
13.13 CD40LG HLA-B HLA-C IL17A IL23R IL6
5
Show member pathways
12.67 HLA-B HLA-C IL6 LTA TAP1 TAP2
6
Show member pathways
12.64 CD40LG IL6 LTA TNF TNFRSF1B
7
Show member pathways
12.49 HLA-B HLA-C IL6 MICA TNF
8 12.45 CD40LG IL17A TAP1 TAP2 TNF TNFRSF1B
9
Show member pathways
12.44 CD40LG LTA TNF TNFRSF1B
10
Show member pathways
12.44 CD40LG HLA-B HLA-C IL17A IL6 LTA
11
Show member pathways
12.41 HLA-B HLA-C TAP1 TAP2
12
Show member pathways
12.4 HLA-B HLA-C IL17A IL23R IL6 LTA
13
Show member pathways
12.36 CD40LG IL17A IL6 TNF
14
Show member pathways
12.36 IL17A IL23R IL6 NOD2 TNF
15 12.33 HLA-B HLA-C IL6 LTA TNF
16
Show member pathways
12.15 IL17A IL23R IL6 LTA TNF
17 12.07 HLA-B HLA-C TAP1 TAP2
18 12 CD40LG HLA-B HLA-C MICA
19 11.86 IL17A IL23R IL6 TNF TNFRSF1B
20 11.81 CD40LG LTA TNF
21
Show member pathways
11.8 IL17A IL23R IL6
22 11.8 IL6 LTA NOD2 TNF TNFRSF1B
23 11.78 IL17A IL6 TNF
24 11.7 IL17A IL23R LTA TNF
25
Show member pathways
11.68 CD40LG TNF TNFRSF1B
26
Show member pathways
11.61 CD40LG IL6 TNF
27 11.53 LTA TNF TNFRSF1B
28
Show member pathways
11.48 LTA TNF TNFRSF1B
29 11.46 IL6 TNF TNFRSF1B
30 11.46 CD40LG IL6 TNF
31 11.3 CD40LG TAP1 TAP2
32 11.23 IL17A IL6 TNF
33 10.97 CRP IL6 TNF
34 10.5 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2

GO Terms for Spondylitis

Cellular components related to Spondylitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.97 ANTXR2 CHI3L1 ERAP1 ERAP2 HLA-B HLA-C
2 extracellular space GO:0005615 9.85 CD40LG CHI3L1 CRP ERAP1 IL17A IL6
3 external side of plasma membrane GO:0009897 9.73 ANTXR2 CD40LG IL17A TNF
4 cell surface GO:0009986 9.5 ANTXR2 CD40LG HLA-B HLA-C MICA NOD2
5 MHC class I protein complex GO:0042612 9.4 HLA-B HLA-C
6 TAP complex GO:0042825 9.32 TAP1 TAP2
7 phagocytic vesicle membrane GO:0030670 8.92 HLA-B HLA-C TAP1 TAP2
8 extracellular region GO:0005576 10 ANTXR2 CD40LG CHI3L1 CRP ERAP1 IL17A

Biological processes related to Spondylitis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.94 ERAP1 ERAP2 TAP1 TAP2
2 regulation of immune response GO:0050776 9.92 CD40LG HLA-B HLA-C MICA
3 cytokine-mediated signaling pathway GO:0019221 9.92 IL17A IL23R IL6 TNF TNFRSF1B
4 immune system process GO:0002376 9.92 ERAP1 ERAP2 HLA-B HLA-C IL23R NOD2
5 immune response GO:0006955 9.86 CD40LG HLA-B HLA-C IL17A IL6 LTA
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 CD40LG IL6 NOD2 TNF
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.81 CD40LG LTA TNF TNFRSF1B
8 positive regulation of T cell proliferation GO:0042102 9.77 CD40LG IL23R IL6
9 humoral immune response GO:0006959 9.77 IL6 LTA TNF
10 defense response to Gram-positive bacterium GO:0050830 9.76 CRP IL6 LTA TNF
11 positive regulation of interleukin-6 production GO:0032755 9.75 IL6 NOD2 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.73 IL23R LTA TNF
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.71 HLA-B HLA-C TAP1 TAP2
14 positive regulation of interleukin-17 production GO:0032740 9.63 IL23R NOD2
15 peptide transport GO:0015833 9.63 TAP1 TAP2
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.62 HLA-B HLA-C
17 positive regulation of osteoclast differentiation GO:0045672 9.61 IL17A IL23R TNF
18 inflammatory response GO:0006954 9.61 CD40LG CHI3L1 CRP IL17A IL23R IL6
19 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.58 TAP1 TAP2
20 regulation of immunoglobulin secretion GO:0051023 9.57 CD40LG TNF
21 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.55 LTA TNF
22 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
23 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.49 LTA TNF
24 cytosol to ER transport GO:0046967 9.48 TAP1 TAP2
25 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.46 ERAP1 ERAP2 TAP1 TAP2
26 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.1 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2
27 regulation of signaling receptor activity GO:0010469 10.01 CD40LG IL17A IL6 LTA TNF
28 viral process GO:0016032 10 HLA-B HLA-C MICA TAP1 TAP2

Molecular functions related to Spondylitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC protein binding GO:0042287 9.48 TAP1 TAP2
2 interleukin-6 receptor binding GO:0005138 9.46 ERAP1 IL6
3 peptide-transporting ATPase activity GO:0015440 9.43 TAP1 TAP2
4 TAP1 binding GO:0046978 9.4 TAP1 TAP2
5 peptide antigen-transporting ATPase activity GO:0015433 9.37 TAP1 TAP2
6 peptide antigen binding GO:0042605 9.33 HLA-B HLA-C TAP1
7 peptide transmembrane transporter activity GO:1904680 9.32 TAP1 TAP2
8 MHC class Ib protein binding GO:0023029 9.26 TAP1 TAP2
9 tumor necrosis factor receptor binding GO:0005164 9.13 CD40LG LTA TNF
10 cytokine activity GO:0005125 9.02 CD40LG IL17A IL6 LTA TNF

Sources for Spondylitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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