Aliases & Classifications for Spondylitis

MalaCards integrated aliases for Spondylitis:

Name: Spondylitis 12 76 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6590
ICD10 33 M46
ICD9CM 35 720.8 720.89
MeSH 44 D013166

Summaries for Spondylitis

MalaCards based summary : Spondylitis is related to juvenile ankylosing spondylitis and spondyloarthropathy 1, and has symptoms including sciatica An important gene associated with Spondylitis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Sulfasalazine and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Spondylitis is an inflammation of the vertebra. It is a form of spondylopathy. In many cases spondylitis... more...

Related Diseases for Spondylitis

Diseases related to Spondylitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 433)
# Related Disease Score Top Affiliating Genes
1 juvenile ankylosing spondylitis 34.0 IL1RN TNF TNFRSF1B
2 spondyloarthropathy 1 33.5 CRP HLA-B IL17A NOD2 TNF TNFRSF1B
3 psoriatic arthritis 31.2 CRP HLA-B HLA-C IL17A IL23R LTA
4 uveitis 30.7 HLA-B IL17A NOD2 TNF
5 reactive arthritis 30.6 CRP HLA-B IL17A TNF
6 spondyloarthropathy 30.6 HLA-B HLA-C IL17A TNF
7 arthritis 30.6 IL17A IL1RN LTA MICA NOD2 TNF
8 spondylarthropathy 30.4 LTA NOD2 TNF
9 crohn's disease 30.3 CRP IL23R NOD2 TNF
10 brucellosis 30.2 CRP IL1RN TNF
11 arthropathy 30.2 CRP MICA TNF
12 rheumatoid arthritis 30.2 CHI3L1 CRP HLA-B IL17A IL1RN TNF
13 iritis 30.2 HLA-B TNFRSF1B
14 vasculitis 30.2 CRP HLA-B TNF TNFRSF1B
15 rheumatic disease 30.2 CRP HLA-B TNF
16 familial mediterranean fever 30.1 CRP IL1RN NOD2 TNF
17 colitis 30.0 IL17A IL23R NOD2 TNF
18 synovitis 30.0 CRP IL1RN TNF
19 takayasu arteritis 29.9 CRP HLA-B MICA TNF
20 psoriasis 29.9 HLA-C IL17A IL23R LTA MICA TNF
21 pustulosis of palm and sole 29.9 IL1RN TNF TNFRSF1B
22 periodontitis 29.8 CRP IL17A TNF
23 temporal arteritis 29.8 CRP IL1RN TNF
24 ulcerative colitis 29.7 CRP IL17A IL23R NOD2 TNF
25 bone inflammation disease 29.7 CRP IL17A IL1RN TNF TNFRSF1B
26 juvenile rheumatoid arthritis 29.7 CRP IL1RN LTA TNF TNFRSF1B
27 hidradenitis suppurativa 29.6 IL17A NOD2 TNF
28 hidradenitis 29.6 IL17A NOD2 TNF
29 adult-onset still's disease 29.6 CRP IL1RN TNF
30 orbital cellulitis 29.6 CRP IL1RN LTA
31 mycoplasma pneumoniae pneumonia 29.5 CRP IL17A TNF
32 lyme disease 29.5 CRP IL17A TNF
33 joint disorders 29.5 IL17A IL1RN TNF
34 bronchiolitis 29.5 CRP IL17A TNF
35 granulomatous dermatitis 29.4 NOD2 TNF TNFRSF1B
36 ileitis 29.4 IL17A NOD2 TNF
37 sarcoidosis 1 29.3 LTA NOD2 TNF TNFRSF1B
38 autoimmune disease 29.3 HLA-B IL17A IL1RN LTA TNF TNFRSF1B
39 mycobacterium tuberculosis 1 29.2 IL17A TNF TNFRSF1B
40 gastrointestinal system disease 29.2 CRP IL17A NOD2 TNF
41 inflammatory bowel disease 28.9 CHI3L1 CRP HLA-B IL17A IL1RN IL23R
42 behcet syndrome 28.5 CRP ERAP1 ERAP2 HLA-B HLA-C IL17A
43 gonococcal spondylitis 12.1
44 spinal disease 11.4
45 ossification of the posterior longitudinal ligament of spine 11.4
46 inflammatory spondylopathy 11.1
47 kummell's disease 11.1
48 temporomandibular ankylosis 11.0
49 anterior uveitis 10.4
50 cauda equina syndrome 10.4

Comorbidity relations with Spondylitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Spondylitis:



Diseases related to Spondylitis

Symptoms & Phenotypes for Spondylitis

UMLS symptoms related to Spondylitis:


sciatica

GenomeRNAi Phenotypes related to Spondylitis according to GeneCards Suite gene sharing:

26 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.9 HLA-B HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.9 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.9 HLA-B HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.9 HLA-B HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.9 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.9 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.9 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.9 HLA-B HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.9 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.9 NOD2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.9 NOD2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.9 HLA-B HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.9 HLA-B HLA-C MICA NOD2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.9 NOD2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.9 NOD2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.9 HLA-C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.9 NOD2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.9 HLA-B HLA-C
19 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.9 NOD2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.9 NOD2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.9 MICA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.9 HLA-C
23 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.9 MICA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.9 HLA-B HLA-C
25 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.9 HLA-B HLA-C
26 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.9 MICA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.9 HLA-C

MGI Mouse Phenotypes related to Spondylitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 ANO6 CHI3L1 ERAP1 IL17A IL1RN IL23R
2 immune system MP:0005387 9.77 ANTXR2 CHI3L1 CRP ERAP1 IL17A IL1RN
3 skeleton MP:0005390 9.28 ANO6 IL17A IL1RN LTA NOD2 SNAPC4

Drugs & Therapeutics for Spondylitis

Drugs for Spondylitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 276)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
2
Etanercept Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 185243-69-0
3
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
4
Adalimumab Approved Phase 4,Phase 2,Phase 3,Not Applicable 331731-18-1 16219006
5
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
6
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
7
Pamidronate Approved Phase 4,Phase 1,Phase 2 40391-99-9 4674
8
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 1302 156391
9
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
10
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
11
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
12
Rifampicin Approved Phase 4,Phase 3 13292-46-1 5458213 5381226
13
Ethambutol Approved Phase 4 74-55-5 3279 14052
14
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
15
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
16
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
17
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
18
Acetaminophen Approved Phase 4,Early Phase 1,Not Applicable 103-90-2 1983
19
Aceclofenac Approved, Investigational Phase 4 89796-99-6
20
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 202409-33-4 123619
21
Indomethacin Approved, Investigational Phase 4,Phase 3 53-86-1 3715
22
Hydroxychloroquine Approved Phase 4,Phase 3,Not Applicable 118-42-3 3652
23
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 73590-58-6 4594
24
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2 71125-38-7 54677470 5281106
25
Tofacitinib Approved, Investigational Phase 4,Phase 3,Phase 2 477600-75-2
26 Ixekizumab Approved, Investigational Phase 4,Phase 3 1143503-69-8
27
Apremilast Approved, Investigational Phase 4,Phase 3,Phase 2 608141-41-9 11561674
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
29 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
34 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3,Phase 1,Not Applicable
35 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
36 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
40 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
41 Natriuretic Agents Phase 4
42 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Natriuretic Peptide, Brain Phase 4
44 Proton Pump Inhibitors Phase 4,Phase 3,Phase 1
45 Anti-Ulcer Agents Phase 4,Phase 3,Phase 1
46 Antacids Phase 4,Phase 3,Phase 1
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 beta-endorphin Phase 4
49 Melanocyte-Stimulating Hormones Phase 4
50 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 683)
# Name Status NCT ID Phase Drugs
1 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
2 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
3 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
4 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
5 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
6 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
7 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
8 Treatment of Axial Spondyloarthritis by Recombinant Human Tumor Necrosis Factor-α Receptor Ⅱ IgG Fc Fusion Protein Unknown status NCT02364479 Phase 4 etanercept;etanercept (half dose);placebo
9 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
10 The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis Unknown status NCT02477852 Phase 4 Isoniazid;Rifampicin;Ethambutol;Pyrazinamide
11 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
12 Efficacy and Safety of Loxoprofen Hydrogel Patch in Patients With Ankylosing Spondylitis Completed NCT03800797 Phase 4 Loxoprofen sodium hydrogel patch;Loxoprofen sodium tablet
13 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
14 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
15 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
16 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
17 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
18 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
19 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
20 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
21 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
22 Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Active Ankylosing Spondylitis Completed NCT01934933 Phase 4 celebrex;Enbrel;Enbrel plus Celebrex
23 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
24 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
25 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
26 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
27 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
28 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
29 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
30 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
31 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
32 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
33 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
34 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
35 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
36 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
37 Evaluation of a Protocol for Dose Reduction in Patients With Spondylarthropathies and Clinical Remission With Anti-TNF Completed NCT01604629 Phase 4 Reduced doses of anti-TNF;Stable doses of anti-TNF
38 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
39 Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis Completed NCT01029847 Phase 4 Adalimumab;Placebo
40 Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial Completed NCT01718951 Phase 4 golimumab;Pamidronate
41 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Completed NCT03190603 Phase 4 Celecoxib
42 Serum Creatinine Change / Renal Adverse Effect With Use of Non-steroidal Painkillers in Axial Spondyloarthritis Patients Completed NCT03582332 Phase 4 Indomethacin SR, 75 Mg Oral Capsule, Extended Release;Indomethacin 25 Mg Oral Capsule;Etoricoxib 90 mg;Etoricoxib 60 mg
43 A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis Completed NCT01298531 Phase 4 etanercept;etanercept;placebo
44 Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
45 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
46 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4 Etanercept
47 HUmira in Psoriatic Arthritis Completed NCT01465438 Phase 4 Adalimumab
48 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
49 Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis Completed NCT00245960 Phase 4 etanercept
50 Prevalence of Psoriatic Arthritis in Adults With Psoriasis: An Estimate From Dermatology Practice Completed NCT01147874 Phase 4

Search NIH Clinical Center for Spondylitis

Cochrane evidence based reviews: spondylitis

Genetic Tests for Spondylitis

Anatomical Context for Spondylitis

MalaCards organs/tissues related to Spondylitis:

41
Bone, T Cells, Endothelial, Testes, Eye, Spinal Cord, Heart

Publications for Spondylitis

Articles related to Spondylitis:

(show top 50) (show all 2841)
# Title Authors Year
1
Ankylosing spondylitis: A novel risk factor for atrial fibrillation - A nationwide population-based study. ( 30360993 )
2019
2
Ankylosing spondylitis and mesenchymal stromal/stem cell therapy: a new therapeutic approach. ( 30551369 )
2019
3
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease. ( 29490353 )
2018
4
Concomitant mycotic abdominal aortic aneurysm and lumbartuberculous spondylitis with cauda equina syndrome: a rare condition - a case report and literature review. ( 29479482 )
2018
5
Ankylosing spondylitis and axial spondyloarthritis: recent insights and impact of new classification criteria. ( 29942364 )
2018
6
Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study. ( 29945918 )
2018
7
Q fever spondylitis: 2 cases report. ( 29887174 )
2018
8
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
9
Differences in carotid atherosclerosis between patients with ankylosing spondylitis treated with tumor necrosis factor-I+ antagonists and healthy matched controls. ( 29979389 )
2018
10
Does the preoperative lumbar sagittal profile affect the selection of osteotomy level in pedicle subtraction osteotomy for thoracolumbar kyphosis secondary to ankylosing spondylitis? ( 29966933 )
2018
11
Prevalence and factors associated with disturbed sleep in outpatients with ankylosing spondylitis. ( 29971585 )
2018
12
Characterization of Patients With Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis in the US-Based Corrona Registry. ( 29409123 )
2018
13
Associations Between Cardiorespiratory Fitness and Arterial Stiffness in Ankylosing Spondylitis: A Cross-sectional Study. ( 29961684 )
2018
14
Biomechanical properties of low back myofascial tissue in younger adult ankylosing spondylitis patients and matched healthy control subjects. ( 29936315 )
2018
15
Safety and Efficacy of Golimumab Administered Intravenously in Adults with Ankylosing Spondylitis: Results through Week 28 of the GO-ALIVE Study. ( 29419454 )
2018
16
Atherogenic index of plasma: a useful marker for subclinical atherosclerosis in ankylosing spondylitis : AIP associate with cIMT in AS. ( 29435680 )
2018
17
Coexistence of Ankylosing Spondylitis and Myotonic Dystrophy: Camptocormia or Thoracic Ankylosis. ( 29465620 )
2018
18
Identification of ANKDD1B variants in an ankylosing spondylitis pedigree and a sporadic patient. ( 29976160 )
2018
19
A differential expression network method identifies ankylosing spondylitis-related genes. ( 29970661 )
2018
20
Ankylosing Spondylitis Treatment after First Anti-TNF Drug Failure. ( 29431309 )
2018
21
TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes. ( 29940800 )
2018
22
Increased Rates of Both Knee and Hip Arthroplasties in Older Patients with Ankylosing Spondylitis. ( 29961693 )
2018
23
Ankylosing spondylitis kyphosis surgical correction postoperative evaluation via SRS-22 domain investigation. ( 29316959 )
2018
24
Stability of fatigue, pain, patient global assessment and the Bath Ankylosing Spondylitis Functional Index (BASFI) in spondyloarthropathy patients with stable disease according to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). ( 29299630 )
2018
25
TNF-I+ level affects etanercept clearance: TNF-I+ concentration as a new correction factor of allometric scaling to predict individual etanercept clearances in patients with ankylosing spondylitis. ( 29436715 )
2018
26
Hepatosplenic T-Cell Lymphoma Arising in a Patient Treated With Tumor Necrosis Factor-I+ Inhibitors for Ankylosing Spondylitis. ( 29933321 )
2018
27
Pulmonary Sarcoidosis following Etanercept Treatment for Ankylosing Spondylitis: A Case Report and Review of the Literature. ( 29610700 )
2018
28
Using Self-Reported Patient Experiences to Understand Patient Burden: Learnings from Digital Patient Communities in Ankylosing Spondylitis. ( 29450863 )
2018
29
Association of Crohn's disease-related chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and faecal calprotectin. ( 29967744 )
2018
30
Assessment of effectiveness and safety of biosimilar infliximab (CT-P13) in a real-life setting for treatment of patients with active rheumatoid arthritis or ankylosing spondylitis. ( 29439591 )
2018
31
Bacille Calmette-GuAcrin (BCG) spondylitis with adjacent mycotic aortic aneurysm after intravesical BCG therapy: a case report and literature review. ( 29954321 )
2018
32
A case of ankylosing spondylitis with concurrent Takayasu arteritis. ( 29690806 )
2018
33
The efficiency of inspiratory muscle training in patients with ankylosing spondylitis. ( 29943207 )
2018
34
Screening for key genes and transcription factors in ankylosing spondylitis by RNA-Seq. ( 29434723 )
2018
35
Association of polymorphisms in ERAP1 and risk of ankylosing spondylitis in a Chinese population. ( 29278768 )
2018
36
MMP-2 silencing reduces the osteogenic transformation of fibroblasts by inhibiting the activation of the BMP/Smad pathway in ankylosing spondylitis. ( 29435070 )
2018
37
A retrospective study of transcutaneous electrical nerve stimulation for chronic pain following ankylosing spondylitis. ( 29979392 )
2018
38
Immune cells involved in the pathogenesis of ankylosing spondylitis. ( 29428668 )
2018
39
Treatment patterns among patients with rheumatic disease (rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated arthritis (UnA)) treated with subcutaneous TNF inhibitors. ( 29667098 )
2018
40
Discrimination of pyogenic spondylitis from brucellar spondylitis on MRI. ( 29952971 )
2018
41
Bickerstaff brainstem encephalitis in a patient with ankylosing spondylitis on tumour necrosis factor-alpha inhibitor. ( 29465358 )
2018
42
Secukinumab in pregnancy: outcomes in psoriasis, psoriatic arthritis and ankylosing spondylitis from the global safety database. ( 29927479 )
2018
43
Red Blood Cell Distribution Width in Rheumatoid Arthritis, Ankylosing Spondylitis and Osteoarthritis: True Inflammatory Index or Effect of Anemia? ( 29970432 )
2018
44
Bone formation in ankylosing spondylitis during anti-tumour necrosis factor therapy imaged by 18F-fluoride positron emission tomography. ( 29415219 )
2018
45
Complex role of IL-23R polymorphisms on ankylosing spondylitis: a meta-analysis. ( 29944013 )
2018
46
Tuberculous Aortitis Associated With Pleuritis and Spondylitis. ( 29398471 )
2018
47
The role of gut microbiota and IL-23/IL-17 pathway in ankylosing spondylitis immunopathogenesis: New insights and updates. ( 29409751 )
2018
48
Response to Tumor Necrosis Factor Inhibition in Male and Female Patients with Ankylosing Spondylitis: Data from a Swiss Cohort. ( 29449504 )
2018
49
Comorbidity, disability, and healthcare expenditure of ankylosing spondylitis in Korea: A population-based study. ( 29420599 )
2018
50
The association of HLA-B27 and Klebsiella pneumoniae in ankylosing spondylitis: A systematic review. ( 29438717 )
2018

Variations for Spondylitis

Expression for Spondylitis

Search GEO for disease gene expression data for Spondylitis.

Pathways for Spondylitis

Pathways related to Spondylitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 ANO6 CHI3L1 CRP ERAP1 ERAP2 HLA-B
2
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13.08 HLA-B HLA-C IL17A IL1RN IL23R LTA
3
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12.86 HLA-B HLA-C MICA TAP1 TAP2 TNF
4
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12.62 HLA-B HLA-C LTA TAP1 TAP2 TNF
5
Show member pathways
12.55 HLA-B HLA-C IL17A LTA MICA TAP1
6
Show member pathways
12.38 HLA-B HLA-C MICA TNF
7
Show member pathways
12.34 HLA-B HLA-C TAP1 TAP2
8 12.29 HLA-B HLA-C LTA TNF
9 12.25 IL17A IL1RN TAP1 TAP2 TNF TNFRSF1B
10
Show member pathways
12.13 HLA-B HLA-C IL17A LTA TNF
11 12.07 HLA-B HLA-C TAP1 TAP2 TNF
12 12.02 HLA-B HLA-C TAP1 TAP2
13
Show member pathways
11.93 IL17A IL23R LTA TNF
14 11.85 IL17A IL23R TNF TNFRSF1B
15 11.82 LTA NOD2 TNF TNFRSF1B
16 11.61 IL17A IL23R LTA TNF
17 11.6 IL17A IL1RN TNF
18 11.48 LTA TNF TNFRSF1B
19
Show member pathways
11.43 LTA TNF TNFRSF1B
20 11.41 IL1RN TNF TNFRSF1B
21 10.5 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2

GO Terms for Spondylitis

Cellular components related to Spondylitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.97 ANTXR2 CHI3L1 ERAP1 ERAP2 HLA-B HLA-C
2 extracellular space GO:0005615 9.97 CHI3L1 CRP ERAP1 IL17A IL1RN LTA
3 extracellular region GO:0005576 9.96 ANTXR2 CHI3L1 CRP ERAP1 IL17A IL1RN
4 cell surface GO:0009986 9.5 ANO6 ANTXR2 HLA-B HLA-C MICA NOD2
5 MHC class I protein complex GO:0042612 9.43 HLA-B HLA-C
6 MHC class I peptide loading complex GO:0042824 9.4 TAP1 TAP2
7 TAP complex GO:0042825 9.16 TAP1 TAP2
8 phagocytic vesicle membrane GO:0030670 8.92 HLA-B HLA-C TAP1 TAP2

Biological processes related to Spondylitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.94 ERAP1 ERAP2 TAP1 TAP2
2 immune system process GO:0002376 9.92 ERAP1 ERAP2 HLA-B HLA-C IL23R NOD2
3 inflammatory response GO:0006954 9.91 CHI3L1 CRP IL17A IL1RN IL23R TNF
4 cytokine-mediated signaling pathway GO:0019221 9.89 IL17A IL1RN IL23R TNF TNFRSF1B
5 cellular response to lipopolysaccharide GO:0071222 9.85 IL1RN NOD2 TNF TNFRSF1B
6 defense response to Gram-positive bacterium GO:0050830 9.81 CRP LTA TNF
7 positive regulation of JNK cascade GO:0046330 9.79 IL1RN NOD2 TNF
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.76 LTA TNF TNFRSF1B
9 immune response GO:0006955 9.76 HLA-B HLA-C IL17A IL1RN LTA MICA
10 positive regulation of interleukin-6 production GO:0032755 9.75 IL1RN NOD2 TNF
11 positive regulation of interferon-gamma production GO:0032729 9.7 IL23R LTA TNF
12 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.65 IL17A NOD2
13 positive regulation of glial cell proliferation GO:0060252 9.65 LTA TNF
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 TNF TNFRSF1B
15 negative regulation of growth of symbiont in host GO:0044130 9.64 LTA TNF
16 peptide catabolic process GO:0043171 9.63 ERAP1 ERAP2
17 positive regulation of interleukin-17 production GO:0032740 9.62 IL23R NOD2
18 peptide transport GO:0015833 9.61 TAP1 TAP2
19 positive regulation of T cell mediated cytotoxicity GO:0001916 9.61 HLA-B HLA-C IL23R
20 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.6 HLA-B HLA-C
21 negative regulation of lipid storage GO:0010888 9.59 CRP TNF
22 positive regulation of osteoclast differentiation GO:0045672 9.58 IL17A IL23R TNF
23 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.57 HLA-B HLA-C
24 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.56 TAP1 TAP2
25 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.56 HLA-B HLA-C TAP1 TAP2
26 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.54 LTA TNF
27 chronic inflammatory response to antigenic stimulus GO:0002439 9.51 IL1RN TNF
28 cytosol to ER transport GO:0046967 9.48 TAP1 TAP2
29 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.46 LTA TNF
30 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.26 ERAP1 ERAP2 TAP1 TAP2
31 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.1 ERAP1 ERAP2 HLA-B HLA-C TAP1 TAP2
32 neutrophil degranulation GO:0043312 10 ANO6 CHI3L1 HLA-B HLA-C TNFRSF1B

Molecular functions related to Spondylitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 IL17A IL1RN LTA TNF
2 MHC protein binding GO:0042287 9.46 TAP1 TAP2
3 peptide transmembrane transporter activity GO:1904680 9.43 TAP1 TAP2
4 TAP1 binding GO:0046978 9.32 TAP1 TAP2
5 MHC class Ib protein binding GO:0023029 9.26 TAP1 TAP2
6 peptide antigen-transporting ATPase activity GO:0015433 9.16 TAP1 TAP2
7 peptide antigen binding GO:0042605 9.13 HLA-B HLA-C TAP1
8 interleukin-1, type II receptor binding GO:0005151 8.62 ERAP1 IL1RN
9 protein binding GO:0005515 10.3 ANO6 ANTXR2 CHI3L1 CRP ERAP1 HLA-B

Sources for Spondylitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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