SPDA1
MCID: SPN225
MIFTS: 75

Spondyloarthropathy 1 (SPDA1)

Categories: Bone diseases, Genetic diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Spondyloarthropathy 1

MalaCards integrated aliases for Spondyloarthropathy 1:

Name: Spondyloarthropathy 1 57 75 38
Ankylosing Spondylitis 57 38 12 76 53 25 75 37 29 6 43 15 73
Spondyloarthropathy, Susceptibility to, 1 57 13 40
Marie-Strumpell Spondylitis 57 53 75
Bechterew Syndrome 57 53 75
Spondylarthritis Ankylopoietica 25 75
Spondylitis, Ankylosing 25 44
Reiter Syndrome 75 73
Spda1 57 75
Ankylosing Spondylitis, Susceptibility to 57
Spondyloarthritis Ankylopoietica 25
Ankylosing Spondyloarthritis 53
Ankylosing Spondylarthritis 75
Spondylitis Ankylopoietica 25
Marie-Struempell Disease 25
Marie-Strumpell Disease 12
Rheumatoid Spondylitis 75
Spondylitis Ankylosans 75
Spondylitis Ankylosing 55
Spondylarthropathies 73
Arthritis, Psoriatic 73
Psoriatic Arthritis 75
Bekhterev's Disease 12
Arthritis, Reactive 73
Reactive Arthritis 75
Bekhterev Syndrome 12
Bechterew Disease 25
As 25

Characteristics:

OMIM:

57
Inheritance:
multifactorial

Miscellaneous:
overall prevalence is between 0.5 and 14 per 100,000 people per year
genetic heterogeneity (see spondyloarthropathy, susceptibility to, 2 )
spondyloarthropathy includes a spectrum of related disorders, including, 1 - ankylosing spondylitis (as), 2 - a subset of psoriatic arthritis (psa), 3 - reactive arthritis (rea), 4 - arthritis associated with inflammatory bowel disease (aibd), 5 - undifferentiated spondyloarthropathy (uspa)


HPO:

32
spondyloarthropathy 1:
Inheritance heterogeneous multifactorial inheritance


Classifications:



Summaries for Spondyloarthropathy 1

MedlinePlus : 43 Ankylosing spondylitis is a type of arthritis of the spine. It causes inflammation between your vertebrae, which are the bones that make up your spine, and in the joints between your spine and pelvis. In some people, it can affect other joints. AS is more common and more severe in men. It often runs in families. The cause is unknown, but it is likely that both genes and factors in the environment play a role. Early symptoms of AS include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, AS can fuse your vertebrae together, limiting movement. Some people have symptoms that come and go. Others have severe, ongoing pain. A diagnosis of AS is based on your medical history and a physical examination. You may also have imaging or blood tests. AS has no cure, but medicines can relieve symptoms and may keep the disease from getting worse. Eating a healthy diet, not smoking, and exercising can also help. In rare cases, you may need surgery to straighten the spine. NIH: National Institute of Arthritis and Musculoskeletal and Skin Disease

MalaCards based summary : Spondyloarthropathy 1, also known as ankylosing spondylitis, is related to mycoplasma pneumoniae pneumonia and pneumonia, and has symptoms including pain, stiffness in the spine and stiffness in the neck. An important gene associated with Spondyloarthropathy 1 is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Antigen processing and presentation and Innate Immune System. Affiliated tissues include Placenta and Umbilical Cord, and related phenotypes are kyphosis and arrhythmia

Disease Ontology : 12 A bone inflammation disease that results in inflammation in the joints of the spine and pelvis. The disease has symptom pain, has symptom stiffness in the spine, has symptom stiffness in the neck, has symptom stiffness in the hips, has symptom stiffness in the jaw and has symptom stiffness in the rib cage.

Genetics Home Reference : 25 Ankylosing spondylitis is a form of ongoing joint inflammation (chronic inflammatory arthritis) that primarily affects the spine. This condition is characterized by back pain and stiffness that typically appear in adolescence or early adulthood. Over time, back movement gradually becomes limited as the bones of the spine (vertebrae) fuse together. This progressive bony fusion is called ankylosis.

NIH Rare Diseases : 53 Ankylosing spondylitis (AS) is a type of chronic, inflammatory arthritis that mainly affects the spine. It usually begins with inflammation of the joints between the pelvic bones and spine, gradually spreading to the joints between the vertebrae. Signs and symptoms usually begin in adolescence or early adulthood and may include back pain and stiffness. Back movement gradually becomes more limited as the vertebrae fuse together. The condition may also affect the shoulders; ribs; hips; knees; and feet; as well as the eyes; bowel; and very rarely, the heart and lungs. AS is likely caused by a combination of genetic and environmental factors; variations in several genes are thought to affect the risk to develop AS. In most cases, treatment involves exercise and medications to relieve pain and inflammation.

OMIM : 57 Spondyloarthropathy (SpA), one of the commonest chronic rheumatic diseases, includes a spectrum of related disorders comprising the prototype ankylosing spondylitis (AS), a subset of psoriatic arthritis (PsA), reactive arthritis (ReA), arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthropathy (Miceli-Richard et al., 2004). These phenotypes are difficult to differentiate because they may occur simultaneously or sequentially in the same patient. Studies have suggested that a predominant shared component, including HLA-B27, predisposes to all phenotypic subsets, and that these subsets should be considered as various phenotypic expressions of the same disease (Said-Nahal et al., 2000, Said-Nahal et al., 2001). Braun and Sieper (2007) provided a detailed review of ankylosing spondylitis, including clinical features, pathogenesis, and management. (106300)

UniProtKB/Swiss-Prot : 75 Spondyloarthropathy 1: A chronic rheumatic disease with multifactorial inheritance. It includes a spectrum of related disorders comprising ankylosing spondylitis, a subset of psoriatic arthritis, reactive arthritis (e.g. Reiter syndrome), arthritis associated with inflammatory bowel disease and undifferentiated spondyloarthropathy. These disorders may occur simultaneously or sequentially in the same patient, probably representing various phenotypic expressions of the same disease. Ankylosing spondylitis is the form of rheumatoid arthritis affecting the spine and is considered the prototype of seronegative spondyloarthropathies. It produces pain and stiffness as a result of inflammation of the sacroiliac, intervertebral, and costovertebral joints.

Wikipedia : 76 Ankylosing spondylitis (AS) is a type of arthritis in which there is long term inflammation of the... more...

Related Diseases for Spondyloarthropathy 1

Diseases in the Spondyloarthropathy family:

Spondyloarthropathy 1 Spondyloarthropathy 2
Spondyloarthropathy 3 Juvenile Spondyloarthropathy

Diseases related to Spondyloarthropathy 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 8287)
# Related Disease Score Top Affiliating Genes
1 mycoplasma pneumoniae pneumonia 31.6 TNF IL17A CRP
2 pneumonia 31.4 TNF TLR4 CRP
3 acquired immunodeficiency syndrome 31.3 TNF HLA-B B2M
4 kawasaki disease 31.3 TNF MMP3 CRP
5 lyme disease 31.3 TNF IL17A CRP
6 vasculitis 31.3 TNFRSF1B TNF HLA-B CRP
7 cytomegalovirus infection 31.2 TNF HLA-B B2M
8 cystitis 31.2 TNF TLR4 CRP
9 crohn's disease 31.1 TNF NOD2 CRP
10 alveolar echinococcosis 31.1 TNF TLR4 HLA-B
11 aortic aneurysm, familial abdominal, 1 31.1 TNFRSF11B MMP3 CRP
12 juvenile rheumatoid arthritis 31.1 TNFRSF1B TNF CRP
13 critical limb ischemia 31.1 TNFRSF11B TNF
14 leishmaniasis 31.0 TNF TLR4 IL17A
15 drug reaction with eosinophilia and systemic symptoms 31.0 CRP HLA-B TNF
16 sarcoidosis 1 31.0 TNFRSF1B TNF NOD2
17 pyelonephritis 31.0 TNF TLR4 CRP
18 septic arthritis 31.0 TLR4 MMP3 CRP
19 hidradenitis suppurativa 31.0 TNF NOD2 IL17A
20 vascular disease 31.0 TNFRSF11B TNF MMP3 CRP
21 pericoronitis 30.9 TNFRSF1B CRP
22 myeloma, multiple 30.9 TNFRSF11B TNF CRP B2M
23 chlamydia 30.9 TNF TLR4 CRP
24 ileocolitis 30.9 TNF NOD2
25 lymphadenitis 30.9 TNF TLR4 NOD2
26 salpingitis 30.9 TNF CRP
27 prosthetic joint infection 30.9 TNFRSF11B TLR4
28 familial mediterranean fever 30.9 TNF NOD2 CRP
29 uremia 30.9 TNFRSF11B CRP B2M
30 melancholia 30.9 TNF CRP
31 brucellosis 30.9 TNF TLR4 CRP
32 typhoid fever 30.9 TNF TLR4 CRP
33 takayasu arteritis 30.9 CRP HLA-B MMP3 TNF
34 chorioamnionitis 30.8 TNF TLR4 CRP
35 reactive arthritis 30.8 CRP HLA-B IL17A TNF
36 echinococcosis 30.8 HLA-B IL17A TLR4 TNF
37 exanthem 30.8 TNFRSF1B TNF CRP
38 atherosclerosis susceptibility 30.8 TNF TLR4 CRP
39 arthritis 30.7 ANKH IL17A MMP3 NOD2 TNF TNFRSF1B
40 tenosynovitis 30.7 CRP MRAP TNFRSF1B
41 mycobacterium tuberculosis 1 30.7 TNFRSF1B TNF TLR4 IL17A
42 discitis 30.7 MRAP CRP
43 trench fever 30.7 TNF TLR4
44 q fever 30.7 TNF TLR4 NOD2
45 pyelitis 30.7 TLR4 CRP B2M
46 melkersson-rosenthal syndrome 30.6 TNFRSF1B TNF NOD2
47 pyuria 30.6 MRAP CRP
48 cerebrovascular disease 30.6 TNF TLR4 CRP
49 mesenteric lymphadenitis 30.6 NOD2 MRAP CRP
50 rheumatoid arthritis 30.5 CRP HLA-B IL17A MMP3 TLR4 TNF

Comorbidity relations with Spondyloarthropathy 1 via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Osteoporosis
Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Spondyloarthropathy 1:



Diseases related to Spondyloarthropathy 1

Symptoms & Phenotypes for Spondyloarthropathy 1

Symptoms via clinical synopsis from OMIM:

57
Head And Neck Eyes:
anterior uveitis

Abdomen Gastrointestinal:
inflammatory bowel disease (crohns disease and ulcerative colitis)

Skeletal Pelvis:
arthritis (hip)

Skin Nails Hair Skin:
psoriasis

Cardiovascular Heart:
aortic insufficiency
aortitis
cardiac conduction abnormalities

Skeletal Spine:
accentuated kyphosis
back stiffness
nocturnal back pain
ankylosing spondylitis
sacroiliitis
more
Skeletal Limbs:
peripheral arthritis (oligoarticular or polyarticular)
peripheral enthesitis

Laboratory Abnormalities:
hla-b27 haplotype association (95% patients)
rheumatoid factor negative


Clinical features from OMIM:

106300

Symptoms:

12
  • pain
  • stiffness in the spine
  • stiffness in the neck
  • stiffness in the hips
  • stiffness in the jaw
  • stiffness in the rib cage

Human phenotypes related to Spondyloarthropathy 1:

32 (show all 10)
# Description HPO Frequency HPO Source Accession
1 kyphosis 32 HP:0002808
2 arrhythmia 32 HP:0011675
3 inflammation of the large intestine 32 HP:0002037
4 back pain 32 HP:0003418
5 aortic regurgitation 32 HP:0001659
6 psoriasiform dermatitis 32 HP:0003765
7 enthesitis 32 HP:0100686
8 anterior uveitis 32 HP:0012122
9 hip osteoarthritis 32 HP:0008843
10 sacroiliac arthritis 32 HP:0012317

UMLS symptoms related to Spondyloarthropathy 1:


back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Spondyloarthropathy 1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 ANKH B2M CD163 IL17A MMP3 NOD2
2 immune system MP:0005387 9.73 ANKH B2M CD163 CRP IL17A MMP3
3 skeleton MP:0005390 9.23 ANKH IL17A MMP3 NOD2 TLR4 TNF

Drugs & Therapeutics for Spondyloarthropathy 1

Search Clinical Trials , NIH Clinical Center for Spondyloarthropathy 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spondyloarthropathy 1 cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondyloarthropathy 1:
Umbilical cord-derived mesenchymal stem cells to treat ankylosing spondylitis
Embryonic/Adult Cultured Cells Related to Spondyloarthropathy 1:
Umbilical cord-derived mesenchymal stem cells (family)
Placenta-derived mesenchymal stem cells (family)

Cochrane evidence based reviews: spondylitis, ankylosing

Genetic Tests for Spondyloarthropathy 1

Genetic tests related to Spondyloarthropathy 1:

# Genetic test Affiliating Genes
1 Ankylosing Spondylitis 29 HLA-B

Anatomical Context for Spondyloarthropathy 1

MalaCards organs/tissues related to Spondyloarthropathy 1:

41
Bone, Eye, T Cells, Testes, Heart, Endothelial, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Spondyloarthropathy 1:
# Tissue Anatomical CompartmentCell Relevance
1 Placenta Chorionic Villus Chorionic Mesenchymal Stromal Cells Potential therapeutic candidate
2 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
3 Blood Cord Blood Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Spondyloarthropathy 1

Articles related to Spondyloarthropathy 1:

(show top 50) (show all 2663)
# Title Authors Year
1
Ankylosing spondylitis and mesenchymal stromal/stem cell therapy: a new therapeutic approach. ( 30551369 )
2019
2
Ankylosing spondylitis: A novel risk factor for atrial fibrillation - A nationwide population-based study. ( 30360993 )
2019
3
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease. ( 29490353 )
2018
4
Ankylosing spondylitis and axial spondyloarthritis: recent insights and impact of new classification criteria. ( 29942364 )
2018
5
Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study. ( 29945918 )
2018
6
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
7
Differences in carotid atherosclerosis between patients with ankylosing spondylitis treated with tumor necrosis factor-I+ antagonists and healthy matched controls. ( 29979389 )
2018
8
Does the preoperative lumbar sagittal profile affect the selection of osteotomy level in pedicle subtraction osteotomy for thoracolumbar kyphosis secondary to ankylosing spondylitis? ( 29966933 )
2018
9
Prevalence and factors associated with disturbed sleep in outpatients with ankylosing spondylitis. ( 29971585 )
2018
10
Characterization of Patients With Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis in the US-Based Corrona Registry. ( 29409123 )
2018
11
Associations Between Cardiorespiratory Fitness and Arterial Stiffness in Ankylosing Spondylitis: A Cross-sectional Study. ( 29961684 )
2018
12
Biomechanical properties of low back myofascial tissue in younger adult ankylosing spondylitis patients and matched healthy control subjects. ( 29936315 )
2018
13
Safety and Efficacy of Golimumab Administered Intravenously in Adults with Ankylosing Spondylitis: Results through Week 28 of the GO-ALIVE Study. ( 29419454 )
2018
14
Atherogenic index of plasma: a useful marker for subclinical atherosclerosis in ankylosing spondylitis : AIP associate with cIMT in AS. ( 29435680 )
2018
15
Coexistence of Ankylosing Spondylitis and Myotonic Dystrophy: Camptocormia or Thoracic Ankylosis. ( 29465620 )
2018
16
Identification of ANKDD1B variants in an ankylosing spondylitis pedigree and a sporadic patient. ( 29976160 )
2018
17
A differential expression network method identifies ankylosing spondylitis-related genes. ( 29970661 )
2018
18
Ankylosing Spondylitis Treatment after First Anti-TNF Drug Failure. ( 29431309 )
2018
19
TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes. ( 29940800 )
2018
20
Increased Rates of Both Knee and Hip Arthroplasties in Older Patients with Ankylosing Spondylitis. ( 29961693 )
2018
21
Ankylosing spondylitis kyphosis surgical correction postoperative evaluation via SRS-22 domain investigation. ( 29316959 )
2018
22
Stability of fatigue, pain, patient global assessment and the Bath Ankylosing Spondylitis Functional Index (BASFI) in spondyloarthropathy patients with stable disease according to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). ( 29299630 )
2018
23
TNF-I+ level affects etanercept clearance: TNF-I+ concentration as a new correction factor of allometric scaling to predict individual etanercept clearances in patients with ankylosing spondylitis. ( 29436715 )
2018
24
Hepatosplenic T-Cell Lymphoma Arising in a Patient Treated With Tumor Necrosis Factor-I+ Inhibitors for Ankylosing Spondylitis. ( 29933321 )
2018
25
Pulmonary Sarcoidosis following Etanercept Treatment for Ankylosing Spondylitis: A Case Report and Review of the Literature. ( 29610700 )
2018
26
Using Self-Reported Patient Experiences to Understand Patient Burden: Learnings from Digital Patient Communities in Ankylosing Spondylitis. ( 29450863 )
2018
27
Association of Crohn's disease-related chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and faecal calprotectin. ( 29967744 )
2018
28
Assessment of effectiveness and safety of biosimilar infliximab (CT-P13) in a real-life setting for treatment of patients with active rheumatoid arthritis or ankylosing spondylitis. ( 29439591 )
2018
29
A case of ankylosing spondylitis with concurrent Takayasu arteritis. ( 29690806 )
2018
30
The efficiency of inspiratory muscle training in patients with ankylosing spondylitis. ( 29943207 )
2018
31
Screening for key genes and transcription factors in ankylosing spondylitis by RNA-Seq. ( 29434723 )
2018
32
Association of polymorphisms in ERAP1 and risk of ankylosing spondylitis in a Chinese population. ( 29278768 )
2018
33
MMP-2 silencing reduces the osteogenic transformation of fibroblasts by inhibiting the activation of the BMP/Smad pathway in ankylosing spondylitis. ( 29435070 )
2018
34
A retrospective study of transcutaneous electrical nerve stimulation for chronic pain following ankylosing spondylitis. ( 29979392 )
2018
35
Immune cells involved in the pathogenesis of ankylosing spondylitis. ( 29428668 )
2018
36
Treatment patterns among patients with rheumatic disease (rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated arthritis (UnA)) treated with subcutaneous TNF inhibitors. ( 29667098 )
2018
37
Bickerstaff brainstem encephalitis in a patient with ankylosing spondylitis on tumour necrosis factor-alpha inhibitor. ( 29465358 )
2018
38
Secukinumab in pregnancy: outcomes in psoriasis, psoriatic arthritis and ankylosing spondylitis from the global safety database. ( 29927479 )
2018
39
Red Blood Cell Distribution Width in Rheumatoid Arthritis, Ankylosing Spondylitis and Osteoarthritis: True Inflammatory Index or Effect of Anemia? ( 29970432 )
2018
40
Bone formation in ankylosing spondylitis during anti-tumour necrosis factor therapy imaged by 18F-fluoride positron emission tomography. ( 29415219 )
2018
41
Complex role of IL-23R polymorphisms on ankylosing spondylitis: a meta-analysis. ( 29944013 )
2018
42
The role of gut microbiota and IL-23/IL-17 pathway in ankylosing spondylitis immunopathogenesis: New insights and updates. ( 29409751 )
2018
43
Response to Tumor Necrosis Factor Inhibition in Male and Female Patients with Ankylosing Spondylitis: Data from a Swiss Cohort. ( 29449504 )
2018
44
Comorbidity, disability, and healthcare expenditure of ankylosing spondylitis in Korea: A population-based study. ( 29420599 )
2018
45
The association of HLA-B27 and Klebsiella pneumoniae in ankylosing spondylitis: A systematic review. ( 29438717 )
2018
46
Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitis. ( 29741584 )
2018
47
Diffusion-weighted Imaging Is a Sensitive and Specific Magnetic Resonance Sequence in the Diagnosis of Ankylosing Spondylitis. ( 29449501 )
2018
48
Association of Acute Myocardial Infarction with ankylosing Spondylitis: A nationwide longitudinal cohort study. ( 30131197 )
2018
49
Renal amyloidosis in ankylosing spondylitis: A monocentric study and review of literature. ( 29657208 )
2018
50
Choroidal thickness changes determined by EDI-OCT on acute anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. ( 28197814 )
2018

Variations for Spondyloarthropathy 1

ClinVar genetic disease variations for Spondyloarthropathy 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HLA-B HLA-B, HLA-B27 undetermined variant risk factor

Expression for Spondyloarthropathy 1

Search GEO for disease gene expression data for Spondyloarthropathy 1.

Pathways for Spondyloarthropathy 1

Pathways related to Spondyloarthropathy 1 according to KEGG:

37
# Name Kegg Source Accession
1 Antigen processing and presentation hsa04612

Pathways related to Spondyloarthropathy 1 according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 B2M CRP HLA-B IL17A MMP3 NOD2
2
Show member pathways
13.03 B2M HLA-B IL17A MMP3 NOD2 TNF
3
Show member pathways
12.82 B2M HLA-B TAPBP TLR4 TNF TNFRSF1B
4
Show member pathways
12.62 B2M HLA-B IL17A TAPBP TNF TNFRSF1B
5
Show member pathways
12.39 IL17A NOD2 TLR4 TNF
6 12.34 B2M IL17A TNF TNFRSF1B
7
Show member pathways
12.26 B2M HLA-B TAPBP TLR4
8 12.08 B2M HLA-B TAPBP TNF
9 11.73 IL17A MMP3 TNF TNFRSF1B
10 11.6 MMP3 NOD2 TNF TNFRSF1B
11 11.34 TLR4 TNF TNFRSF1B
12 11.21 IL17A MMP3 TLR4 TNF
13 10.82 CRP TNF
14 10.78 CD163 IL17A MMP3 TNF
15 10.73 B2M HLA-B TAPBP

GO Terms for Spondyloarthropathy 1

Cellular components related to Spondyloarthropathy 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 B2M HLA-B NOD2 TLR4 TNF
2 MHC class I protein complex GO:0042612 9.16 B2M HLA-B
3 phagocytic vesicle membrane GO:0030670 9.13 B2M HLA-B TAPBP
4 external side of plasma membrane GO:0009897 9.02 B2M CD163 IL17A TLR4 TNF

Biological processes related to Spondyloarthropathy 1 according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.88 IL17A MMP3 TNF TNFRSF1B
2 activation of MAPK activity GO:0000187 9.78 NOD2 TLR4 TNF
3 positive regulation of JNK cascade GO:0046330 9.75 NOD2 TLR4 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.73 NOD2 TLR4 TNF TNFRSF1B
5 regulation of inflammatory response GO:0050727 9.71 NOD2 TLR4 TNF
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.7 TNF TNFRSF11B TNFRSF1B
7 positive regulation of interleukin-6 production GO:0032755 9.65 NOD2 TLR4 TNF
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.63 NOD2 TLR4 TNF
9 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 TNF TNFRSF1B
10 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.59 NOD2 TLR4
11 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.58 B2M HLA-B TAPBP
12 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.57 TLR4 TNF
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.56 B2M HLA-B
14 negative regulation of lipid storage GO:0010888 9.55 CRP TNF
15 positive regulation of interleukin-1 beta secretion GO:0050718 9.54 NOD2 TLR4 USP50
16 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.51 B2M TAPBP
17 positive regulation of interleukin-8 production GO:0032757 9.5 NOD2 TLR4 TNF
18 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.49 TLR4 USP50
19 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.43 B2M HLA-B TAPBP
20 inflammatory response GO:0006954 9.43 CD163 CRP IL17A TLR4 TNF TNFRSF1B
21 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.33 IL17A NOD2 TLR4
22 immune response GO:0006955 9.17 B2M HLA-B IL17A TAPBP TLR4 TNF

Sources for Spondyloarthropathy 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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