SEDT
MCID: SPN405
MIFTS: 50
|
Spondyloepiphyseal Dysplasia Tarda, X-Linked (SEDT)
Categories:
Bone diseases, Fetal diseases, Genetic diseases, Rare diseases
|
|
|
MalaCards integrated aliases for Spondyloepiphyseal Dysplasia Tarda, X-Linked:
Characteristics:Inheritance:
Spondyloepiphyseal Dysplasia Tarda, X-Linked:
X-linked recessive 57
Spondyloepiphyseal Dysplasia Tarda:
Autosomal dominant,Autosomal recessive,X-linked recessive 58
OMIM®:57 (Updated 08-Dec-2022)
Miscellaneous:
arthralgias age of onset 5-10 years carrier females have arthralgias in middle age Classifications:
MalaCards categories:
Global: Genetic diseases Rare diseases Fetal diseases Anatomical: Bone diseases
ICD10:
32
Orphanet: 58
![]() ![]() |
MedlinePlus Genetics: 42 X-linked spondyloepiphyseal dysplasia tarda is a condition that impairs bone growth and occurs almost exclusively in males. The name of the condition indicates that it affects the bones of the spine (spondylo-) and the ends of long bones (epiphyses) in the arms and legs. "Tarda" indicates that signs and symptoms of this condition are not present at birth, but appear later in childhood, typically between ages 6 and 10.Males with X-linked spondyloepiphyseal dysplasia tarda have skeletal abnormalities and short stature. Affected boys grow steadily until late childhood, when their growth slows. Their adult height ranges from 4 feet 6 inches (137 cm) to 5 feet 4 inches (163 cm). Impaired growth of the spinal bones (vertebrae) primarily causes the short stature. Spinal abnormalities include flattened vertebrae (platyspondyly) with hump-shaped bulges, progressive thinning of the discs between vertebrae, and an abnormal curvature of the spine (scoliosis or kyphosis). These spinal problems also cause back pain in people with this condition. Individuals with X-linked spondyloepiphyseal dysplasia tarda have a short torso and neck, and their arms are disproportionately long compared to their height.Other skeletal features of X-linked spondyloepiphyseal dysplasia tarda include an abnormality of the hip joint that causes the upper leg bones to turn inward (coxa vara); multiple abnormalities of the epiphyses, including a short upper end of the thigh bone (femoral neck); and a broad, barrel-shaped chest. A painful joint condition called osteoarthritis that typically occurs in older adults often develops in early adulthood in people with X-linked spondyloepiphyseal dysplasia tarda and worsens over time, most often affecting the hips, knees, and shoulders. MalaCards based summary: Spondyloepiphyseal Dysplasia Tarda, X-Linked, also known as spondyloepiphyseal dysplasia tarda, is related to spondyloepiphyseal dysplasia congenita and osteochondrodysplasia, and has symptoms including arthralgia An important gene associated with Spondyloepiphyseal Dysplasia Tarda, X-Linked is TRAPPC2 (Trafficking Protein Particle Complex Subunit 2), and among its related pathways/superpathways are Metabolism of proteins and Vesicle-mediated transport. Affiliated tissues include bone, and related phenotypes are failure to thrive and disproportionate short-trunk short stature GARD: 19 X-linked spondyloepiphyseal dysplasia tarda is an inherited skeletal disorder that affects males only. Physical characteristics include moderate short-stature (dwarfism); moderate to severe spinal deformities; barrel-chest; disproportionately short trunk and neck; disproportionately long arms, and premature osteoarthritis, especially in the hip joints. Final male adult height ranges from 4 feet 10 inches to 5 feet 6 inches. Other skeletal features of this condition include decreased mobility of the elbow and hip joints, arthritis, and abnormalities of the hip joint which causes the upper leg bones to turn inward. This condition is caused by genetic changes in the TRAPPC2 gene and is inherited in an X-linked recessive pattern. Disease Ontology 11 X-linked spondyloepiphyseal dysplasia tarda: A spondyloepiphyseal dysplasia that is characterized by impaired growth of bones of the spine and the ends of long bones in the arms and legs and has material basis in mutation in the SEDL gene on chromosome Xp22. Spondyloepiphyseal dysplasia tarda: A spondyloepiphyseal dysplasia characterized by impaired growth of the bones of the spine and the ends of the long bones that becomes apparent in after birth. Orphanet: 58 Spondyloepiphyseal dysplasia tarda (SEDT) is characterized by disproportionate short stature in adolescence or adulthood, associated with a short trunk and arms and barrel-shaped chest. UniProtKB/Swiss-Prot: 73 X-linked recessive disorder of endochondral bone formation.
More information from OMIM:
313400
GeneReviews:
NBK1145
|
Human phenotypes related to Spondyloepiphyseal Dysplasia Tarda, X-Linked:58 30 (show top 50) (show all 63)
Symptoms via clinical synopsis from OMIM®:57 (Updated 08-Dec-2022)Clinical features from OMIM®:313400 (Updated 08-Dec-2022)UMLS symptoms related to Spondyloepiphyseal Dysplasia Tarda, X-Linked:arthralgia |
|
Organs/tissues related to Spondyloepiphyseal Dysplasia Tarda, X-Linked:
MalaCards :
Bone
|
Articles related to Spondyloepiphyseal Dysplasia Tarda, X-Linked:(show top 50) (show all 173)
|
ClinVar genetic disease variations for Spondyloepiphyseal Dysplasia Tarda, X-Linked:5 (show top 50) (show all 72)
UniProtKB/Swiss-Prot genetic disease variations for Spondyloepiphyseal Dysplasia Tarda, X-Linked:73
|
Search
GEO
for disease gene expression data for Spondyloepiphyseal Dysplasia Tarda, X-Linked.
|
Pathways related to Spondyloepiphyseal Dysplasia Tarda, X-Linked according to GeneCards Suite gene sharing:
|
Cellular components related to Spondyloepiphyseal Dysplasia Tarda, X-Linked according to GeneCards Suite gene sharing:
Biological processes related to Spondyloepiphyseal Dysplasia Tarda, X-Linked according to GeneCards Suite gene sharing:
|
|