Aliases & Classifications for Spondylolisthesis

MalaCards integrated aliases for Spondylolisthesis:

Name: Spondylolisthesis 57 38 12 29 55 44 15 73

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
spondylolisthesis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 184200
Disease Ontology 12 DOID:6682
ICD10 33 M43.1 M43.10
MeSH 44 D013168
NCIt 50 C35033
MedGen 42 C0038016
SNOMED-CT via HPO 69 263681008 240221008
UMLS 73 C0038016

Summaries for Spondylolisthesis

OMIM : 57 Spondylolisthesis is defined as forward slipping of a vertebral body on the one below it. Spondylolysis is defined as a defect in the pars interarticularis without vertebral slipping (summary by Wiltse et al., 1975). (184200)

MalaCards based summary : Spondylolisthesis is related to spondylolysis and spinal stenosis, and has symptoms including back pain An important gene associated with Spondylolisthesis is BMP7 (Bone Morphogenetic Protein 7), and among its related pathways/superpathways are GPCR Pathway and p70S6K Signaling. The drugs Menthol and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include set of vertebrae, bone and bone marrow, and related phenotypes are spondylolysis and spondylolisthesis at l5-s1

Disease Ontology : 12 A bone structure disease that has material basis in displacement located in set of vertebrae.

Wikipedia : 76 Spondylolisthesis is the slippage or displacement of one vertebra compared to... more...

Related Diseases for Spondylolisthesis

Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 spondylolysis 31.2 BMP7 FTH1 GDF5
2 spinal stenosis 31.1 BMP7 MMP3
3 degenerative disc disease 30.4 BMP2 GDF5
4 osteoarthritis 30.2 GDF5 MMP3 PTGS2
5 jaffer beighton syndrome 11.0
6 frozen shoulder 10.6 GDF5 MMP3
7 endometrial disease 10.5 ESR1 PTGS2
8 cardiomyopathy, familial hypertrophic, 9 10.5 ESR1 FTH1
9 pelvic organ prolapse 10.5 ESR1 MMP3
10 cervicitis 10.4
11 brachydactyly, type a2 10.4 BMP2 GDF5
12 osteochondritis dissecans 10.4 BMP7 MMP3
13 scoliosis 10.3
14 back pain 10.3
15 osseous heteroplasia, progressive 10.3 BMP2 BMP7
16 adenomyosis 10.2 ESR1 MMP3 PTGS2
17 shoulder impingement syndrome 10.2 PROS1 PTGS2
18 aging 10.2
19 bone resorption disease 10.1 BMP2 ESR1
20 polyradiculopathy 10.1 BMP2 IVD
21 neural tube defects 10.0
22 spina bifida occulta 10.0
23 spondylosis 10.0
24 juvenile polyposis syndrome 10.0 BMP2 PTGS2
25 proximal symphalangism 10.0 BMP2 BMP7 GDF5
26 radiculopathy 10.0
27 bone remodeling disease 9.9 BMP2 ESR1
28 idiopathic scoliosis 9.9
29 discitis 9.9
30 cauda equina syndrome 9.9
31 cervical adenocarcinoma 9.8 ESR1 PTGS2
32 osteoporosis 9.8
33 rheumatoid arthritis 9.8
34 scoliosis, isolated 1 9.8
35 brittle bone disorder 9.8
36 bone mineral density quantitative trait locus 15 9.8
37 arthritis 9.8
38 pseudoarthrosis 9.8
39 coronary artery aneurysm 9.8 MMP3 PRRC2A
40 pycnodysostosis 9.7
41 basal cell carcinoma 1 9.7
42 body mass index quantitative trait locus 1 9.7
43 chromosome 16p13.3 deletion syndrome, proximal 9.7
44 polyglucosan body myopathy 1 with or without immunodeficiency 9.7
45 cerebral palsy 9.7
46 loeys-dietz syndrome 9.7
47 inflammatory myofibroblastic tumor 9.7
48 osteomyelitis 9.7
49 gout 9.7
50 ehlers-danlos syndrome 9.7

Graphical network of the top 20 diseases related to Spondylolisthesis:



Diseases related to Spondylolisthesis

Symptoms & Phenotypes for Spondylolisthesis

Symptoms via clinical synopsis from OMIM:

57
Spine:
spondylolisthesis of l5 on s1
defects in posterior spinous processes of l5 and sacrum
spondylolysis


Clinical features from OMIM:

184200

Human phenotypes related to Spondylolisthesis:

32
# Description HPO Frequency HPO Source Accession
1 spondylolysis 32 HP:0003304
2 spondylolisthesis at l5-s1 32 HP:0008489

UMLS symptoms related to Spondylolisthesis:


back pain

GenomeRNAi Phenotypes related to Spondylolisthesis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.58 PTGS2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.58 PTGS2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.58 PTGS2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.58 IVD
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.58 IDS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.58 IDS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.58 IDS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 IDS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.58 IDS IVD PTGS2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 IDS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.58 IDS PTGS2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.58 IDS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.58 PTGS2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.58 IDS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.58 PTGS2

MGI Mouse Phenotypes related to Spondylolisthesis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 BMP2 BMP7 ESR1 FTH1 MMP3 PROS1
2 immune system MP:0005387 9.87 BMP2 BMP7 ESR1 FTH1 IDS MMP3
3 mortality/aging MP:0010768 9.81 BMP2 BMP7 ESR1 FTH1 GDF5 IDS
4 limbs/digits/tail MP:0005371 9.65 BMP2 BMP7 ESR1 GDF5 IDS
5 nervous system MP:0003631 9.56 BMP7 ESR1 FTH1 IDS MMP3 PROS1
6 skeleton MP:0005390 9.17 BMP2 BMP7 ESR1 GDF5 IDS MMP3

Drugs & Therapeutics for Spondylolisthesis

Drugs for Spondylolisthesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4,Phase 2,Not Applicable 2216-51-5 16666
2
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
3
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
4
Pregabalin Approved, Illicit, Investigational Phase 4,Not Applicable 148553-50-8 5486971
5
s 1 (combination) Phase 4,Phase 1,Phase 2,Not Applicable
6 Calcium, Dietary Phase 4,Phase 2
7 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
8 Analgesics, Opioid Phase 4,Not Applicable
9 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
10 Anesthetics, Dissociative Phase 4
11 Anesthetics, General Phase 4
12 Anesthetics, Intravenous Phase 4
13 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
14 Excitatory Amino Acid Antagonists Phase 4
15 Excitatory Amino Acids Phase 4
16 Narcotics Phase 4,Not Applicable
17 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
18 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
19 Anti-Anxiety Agents Phase 4
20 Anticonvulsants Phase 4
21 calcium channel blockers Phase 4
22 Psychotropic Drugs Phase 4
23 Tranquilizing Agents Phase 4
24
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 113775-47-6 68602 5311068
25 Adrenergic Agents Phase 2, Phase 3
26 Adrenergic Agonists Phase 2, Phase 3
27 Adrenergic alpha-2 Receptor Agonists Phase 2, Phase 3
28 Adrenergic alpha-Agonists Phase 2, Phase 3
29 Analgesics, Non-Narcotic Phase 2, Phase 3
30 Hypnotics and Sedatives Phase 2, Phase 3
31
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Not Applicable 50-02-2 5743
32
Cisatracurium Approved Phase 2 96946-41-7
33
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
34
Remifentanil Approved Phase 2 132875-61-7 60815
35
Ropivacaine Approved Phase 2 84057-95-4 71273 175805
36 BB 1101 Phase 2,Not Applicable
37 Dexamethasone acetate Phase 2,Not Applicable 1177-87-3
38 Anesthetics, Local Phase 2
39
Teriparatide Approved, Investigational Not Applicable 52232-67-4 16133850
40
Mepivacaine Approved, Vet_approved Not Applicable 96-88-8 4062
41
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
42
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
43
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
44
Ketorolac Approved Not Applicable 74103-06-3, 66635-83-4 3826
45
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
46
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
47
Racepinephrine Approved Not Applicable 329-65-7 838
48
Silicon Approved, Investigational Not Applicable 7440-21-3 4082203
49
Gabapentin Approved, Investigational Not Applicable 60142-96-3 3446
50
Dimenhydrinate Approved Not Applicable 523-87-5 441281

Interventional clinical trials:

(show top 50) (show all 148)
# Name Status NCT ID Phase Drugs
1 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Unknown status NCT02429908 Phase 4
2 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
3 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
4 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
5 Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis Completed NCT00000411 Phase 4
6 Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation Completed NCT00000410 Phase 4
7 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
8 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
9 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
10 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
11 A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
12 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
13 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
14 Total Facet Arthroplasty System®(TFAS®) Clinical Trial Unknown status NCT00418197 Phase 3
15 Greenwich Lumbar Stenosis SLIP Study Completed NCT00109213 Phase 3
16 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
17 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
18 Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion Recruiting NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo
19 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis Active, not recruiting NCT01618435 Phase 3
20 Peri-Incisional Drug Injection in Lumbar Spine Surgery Not yet recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
21 A Clinical Study of the Dynesys(R) Spinal System Terminated NCT00759057 Phase 3
22 INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine Terminated NCT01415908 Phase 3
23 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
24 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
25 Efficacy and Safety Study of Lumbar Interbody Fusion With MatriTMBONE Associated With Autologous Bone Marrow Unknown status NCT01335243 Phase 2
26 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion Completed NCT00996073 Phase 2
27 Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion Completed NCT01106417 Phase 2
28 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy Completed NCT01097486 Phase 2
29 Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF) Completed NCT00549913 Phase 1, Phase 2
30 Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis Recruiting NCT03100032 Phase 1, Phase 2
31 Transverse Abdominis Plane Block for Anterior Approach Spine Surgery Recruiting NCT02884440 Phase 2 TAP block ropivacaine;TAP block placebo;General anesthesia
32 Safety Study of Mesenchymal Stem Cells and Spinal Fusion Active, not recruiting NCT01552707 Phase 1, Phase 2
33 Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion Active, not recruiting NCT02205138 Phase 2 ALLOB® cells with ceramic scaffold
34 CopiOs Posterolateral Fusion Procedure Terminated NCT01123850 Phase 2
35 Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion Withdrawn NCT00810212 Phase 1, Phase 2
36 Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression Unknown status NCT01338766 Not Applicable
37 Prospective Study of Minimally Invasive Spine Surgery Unknown status NCT01045473
38 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379 Not Applicable
39 Post-market Study of the TOPS™ System Unknown status NCT02234154 Not Applicable
40 Post-market Study of the TOPS™ System Unknown status NCT01933607 Not Applicable
41 Dynesys Spinal System Post Market 522 Study Unknown status NCT01528072 Not Applicable
42 Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain Unknown status NCT01918943
43 Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures Unknown status NCT02171169
44 Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion Unknown status NCT01292252 Not Applicable
45 Efficacy Study of Acupuncture to Treat Spinal Pain Unknown status NCT01909284 Not Applicable
46 Physical Therapy Management in Degenerative Lumbar Diseases and Osteoporosis Unknown status NCT01703403
47 Luna Interbody System for Fusion Trial Unknown status NCT01551901 Not Applicable
48 Lumbar Stabilization Exercises vs Flexor Exercises in Degenerative Spondylolisthesis Completed NCT02664688 Not Applicable
49 XLIF® vs. MAS®TLIF for the Treatment of Symptomatic Lumbar Degenerative Spondylolisthesis With or Without Central Stenosis. Completed NCT01024699
50 Effects of Exercise Intervention in Patients With Spondylolisthesis Related LBP Completed NCT01985776 Not Applicable

Search NIH Clinical Center for Spondylolisthesis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spondylolisthesis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondylolisthesis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spondylolisthesis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spondylolisthesis

Genetic Tests for Spondylolisthesis

Genetic tests related to Spondylolisthesis:

# Genetic test Affiliating Genes
1 Spondylolisthesis 29

Anatomical Context for Spondylolisthesis

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolisthesis:

19
Set Of Vertebrae

MalaCards organs/tissues related to Spondylolisthesis:

41
Bone, Bone Marrow, Testes, Spinal Cord

Publications for Spondylolisthesis

Articles related to Spondylolisthesis:

(show top 50) (show all 922)
# Title Authors Year
1
Natural History of Cervical Degenerative Spondylolisthesis. ( 29952882 )
2018
2
The Challenge of Creating Lordosis in High-Grade Dysplastic Spondylolisthesis. ( 29933805 )
2018
3
Motion Analysis in Lumbar Spinal Stenosis With Degenerative Spondylolisthesis: A Feasibility Study of the 3DCT Technique Comparing Laminectomy Versus Bilateral Laminotomy. ( 29939843 )
2018
4
Posterolateral fusion (PLF) vs. transforaminal lumbar interbody fusion (TLIF) for spondylolisthesis: a systematic review and meta-analysis. ( 29452283 )
2018
5
Decompression with or without concomitant fusion in lumbar stenosis due to degenerative spondylolisthesis: a systematic review. ( 29404693 )
2018
6
A novel noninstrumented surgical approach for foramen reconstruction for isthmic spondylolisthesis in patients with radiculopathy: preliminary clinical and radiographic outcomes. ( 29290136 )
2018
7
Spondylolysis and spondylolisthesis: A review of the literature. ( 29881164 )
2018
8
Reliability and Clinical Utility of the CARDS Classification for Degenerative Spondylolisthesis. ( 28719453 )
2018
9
Spondylolisthesis is Common, Early, and Severe in Loeys-Dietz Syndrome. ( 29889773 )
2018
10
Radiological and functional outcomes of high-grade spondylolisthesis treated by intrasacral fixation, dome resection and circumferential fusion: a retrospective series of 20 consecutive cases with a minimum of 2A years follow-up. ( 29353326 )
2018
11
Direction-changeable lumbar cage versus traditional lumbar cage for treating lumbar spondylolisthesis: A retrospective study. ( 29443791 )
2018
12
Mild (not severe) disc degeneration is implicated in the progression of bilateral L5 spondylolysis to spondylolisthesis. ( 29609581 )
2018
13
Evaluation of the facet joints with magnetic resonance images in the patients with disc degeneration and spondylolisthesis. ( 29909481 )
2018
14
Long-term Minimum Clinically Important Difference(MCID) in Health Related Quality of Life Scores After Instrumented Lumbar Interbody Fusion for Low-Grade Isthmic Spondylolisthesis. ( 29920389 )
2018
15
Does Surgically Managed Grade I Degenerative Lumbar Spondylolisthesis Require Fusion? ( 29975202 )
2018
16
Minimally invasive anterior and lateral transpsoas approaches for closed reduction of grade II spondylolisthesis: initial clinical and radiographic experience. ( 29290134 )
2018
17
Increased rate of lumbar spondylolisthesis in rheumatoid arthritis: a case-control study. ( 29956820 )
2018
18
Comparative Utility of Dynamic and Static Imaging in the Management of Lumbar Spondylolisthesis. ( 29929030 )
2018
19
Assessment of radiographic and clinical outcomes of an articulating expandable interbody cage in minimally invasive transforaminal lumbar interbody fusion for spondylolisthesis. ( 29290133 )
2018
20
Increased PT/SS may play an important role in the pathogenesis of lumbar spondylolisthesis with degenerative lumbar scoliosis. ( 29358108 )
2018
21
Radiographic Classification for Degenerative Spondylolisthesis of the Lumbar Spine Based on Sagittal Balance: A Reliability Study. ( 29886905 )
2018
22
Posterior reversible encephalopathy syndrome with status epilepticus following surgery for lumbar stenosis and spondylolisthesis: case report. ( 29864559 )
2018
23
L5 incidence: an important parameter for spinopelvic balance evaluation in high grade spondylolisthesis. ( 29360579 )
2018
24
Image guidance in transdiscal fixation for high-grade spondylolisthesis in adults with correct spinal balance. ( 29290127 )
2018
25
Utility of Supine Lateral Radiographs for Assessment of Lumbar Segmental Instability in Degenerative Lumbar Spondylolisthesis. ( 29432395 )
2018
26
Diagnosis of Spondylolysis and Spondylolisthesis Is Delayed Six Months After Seeing Nonorthopedic Providers. ( 29735135 )
2018
27
Transforaminal Endoscopic Decompression in the Setting of Lateral Lumbar Spondylolisthesis: Technical Note. ( 29940383 )
2018
28
The importance of proximal femoral angle on sagittal balance and quality of life in children and adolescents with high-grade lumbosacral spondylolisthesis. ( 29445950 )
2018
29
Minimally invasive transforaminal lumbar interbody fusion using bone cement-augmented pedicle screws for lumbar spondylolisthesis in patients with osteoporosis. Case series and review of literature. ( 29322970 )
2018
30
Radiological adjacent-segment degeneration in L4-5 spondylolisthesis: comparison between dynamic stabilization and minimally invasive transforaminal lumbar interbody fusion. ( 29856306 )
2018
31
A comparison of the techniques of direct pars interarticularis repairs for spondylolysis and low-grade spondylolisthesis: a meta-analysis. ( 29290131 )
2018
32
Facet Joint Osteoarthritis Affects Spinal Segmental Motion in Degenerative Spondylolisthesis. ( 29912734 )
2018
33
Current Evidence Regarding the Diagnostic Methods for Pediatric Lumbar Spondylolisthesis: A Report From the Scoliosis Research Society Evidence Based Medicine Committee. ( 29413742 )
2018
34
Current trends in the management of degenerative lumbar spondylolisthesis. ( 29951256 )
2018
35
How many physical therapy sessions are required to reach a good outcome in symptomatic lumbar spondylolisthesis? A retrospective study. ( 29332744 )
2018
36
Surgical outcomes of single-level transforaminal lumbar interbody fusion for degenerative spondylolisthesis with and without kyphotic alignment. ( 29913292 )
2018
37
Does adding interbody fusion to posterolateral fusion increase success in the surgical management of degenerative lumbar spondylolisthesis? ( 29385121 )
2018
38
Outcome of transforaminal lumbar interbody fusion in spondylolisthesis-A clinico-radiological correlation. ( 29881153 )
2018
39
Double-level lumbar spondylolysis and spondylolisthesis: A retrospective study. ( 29548343 )
2018
40
Double-level isthmic spondylolisthesis treated with posterior lumbar interbody fusion with cage. ( 29361854 )
2018
41
Factors predicting opioid dependence in patients undergoing surgery for degenerative spondylolisthesis: analysis from the MarketScan databases. ( 29914294 )
2018
42
Comparison of Decompression, Decompression Plus Fusion, and Decompression Plus Stabilization for Degenerative Spondylolisthesis: A Prospective, Randomized Study. ( 29877872 )
2018
43
Thoracic spondylolisthesis and spinal cord compression in diffuse idiopathic skeletal hyperostosis: a case report. ( 28363281 )
2017
44
Degenerative spondylolisthesis: contemporary review of the role of interbody fusion. ( 27888353 )
2017
45
Single-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion Provides Sustained Improvements in Clinical and Radiological Outcomes up to 5 Years Postoperatively in Patients with Neurogenic Symptoms Secondary to Spondylolisthesis. ( 28443164 )
2017
46
A Change in Lumbar Sagittal Alignment After Single-level Anterior Lumbar Interbody Fusion for Lumbar Degenerative Spondylolisthesis With Normal Sagittal Balance. ( 28746123 )
2017
47
Treatment of chronic traumatic C7-T1 grade III spondylolisthesis with mild neurological deficit: case report. ( 28435924 )
2017
48
Comparing minimally invasive transforaminal lumbar interbody fusion and posterior lumbar interbody fusion for spondylolisthesis: A STROBE-compliant observational study. ( 28906383 )
2017
49
Outcomes of autograft alone versus PEEK+ autograft interbody fusion in the treatment of adult lumbar isthmic spondylolisthesis. ( 28187368 )
2017
50
Lumbar Degenerative Spondylolisthesis: Changes in Surgical Indications and Comparison of Instrumented Fusion with Two Surgical Decompression Procedures: Erratum. ( 28800573 )
2017

Variations for Spondylolisthesis

Expression for Spondylolisthesis

Search GEO for disease gene expression data for Spondylolisthesis.

Pathways for Spondylolisthesis

GO Terms for Spondylolisthesis

Cellular components related to Spondylolisthesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 BMP2 BMP7 FTH1 GDF5 MMP3 PROS1

Biological processes related to Spondylolisthesis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.91 BMP2 FTH1 IVD PTGS2
2 negative regulation of cell proliferation GO:0008285 9.84 BMP2 BMP7 FTH1 PTGS2
3 regulation of apoptotic process GO:0042981 9.81 BMP2 BMP7 ESR1 GDF5
4 response to estradiol GO:0032355 9.7 BMP7 ESR1 PTGS2
5 BMP signaling pathway GO:0030509 9.67 BMP2 BMP7 GDF5
6 positive regulation of neuron differentiation GO:0045666 9.63 BMP2 BMP7 GDF5
7 positive regulation of cell death GO:0010942 9.62 BMP7 PTGS2
8 positive regulation of cell differentiation GO:0045597 9.61 BMP2 BMP7
9 cartilage development GO:0051216 9.61 BMP2 BMP7 GDF5
10 positive regulation of epithelial to mesenchymal transition GO:0010718 9.6 BMP2 BMP7
11 chondrocyte differentiation GO:0002062 9.59 BMP2 GDF5
12 epithelial to mesenchymal transition GO:0001837 9.58 BMP2 BMP7
13 cellular response to BMP stimulus GO:0071773 9.58 BMP2 BMP7
14 bone mineralization GO:0030282 9.57 BMP2 PTGS2
15 positive regulation of bone mineralization GO:0030501 9.56 BMP2 BMP7
16 response to vitamin D GO:0033280 9.55 BMP7 PTGS2
17 SMAD protein signal transduction GO:0060395 9.54 BMP2 BMP7 GDF5
18 cell development GO:0048468 9.5 BMP2 BMP7 GDF5
19 mesenchymal cell differentiation GO:0048762 9.48 BMP2 BMP7
20 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.4 BMP7 ESR1
21 regulation of MAPK cascade GO:0043408 9.33 BMP2 BMP7 GDF5
22 mesenchyme development GO:0060485 9.26 BMP2 BMP7
23 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.13 BMP2 BMP7 GDF5
24 negative regulation of cell cycle GO:0045786 8.8 BMP2 BMP7 PTGS2

Molecular functions related to Spondylolisthesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 BMP2 BMP7 GDF5
2 growth factor activity GO:0008083 9.33 BMP2 BMP7 GDF5
3 BMP receptor binding GO:0070700 8.96 BMP2 BMP7
4 transforming growth factor beta receptor binding GO:0005160 8.8 BMP2 BMP7 GDF5

Sources for Spondylolisthesis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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