Aliases & Classifications for Spondylolisthesis

MalaCards integrated aliases for Spondylolisthesis:

Name: Spondylolisthesis 57 12 54 44 15 37 17 70 32



57 (Updated 20-May-2021)
autosomal dominant


Inheritance autosomal dominant inheritance


External Ids:

Disease Ontology 12 DOID:6682
OMIM® 57 184200
MeSH 44 D013168
NCIt 50 C35033
SNOMED-CT 67 157003009
ICD10 32 M43.1
MedGen 41 C0038016
SNOMED-CT via HPO 68 240221008 263681008
UMLS 70 C0038016

Summaries for Spondylolisthesis

OMIM® : 57 Spondylolisthesis is defined as forward slipping of a vertebral body on the one below it. Spondylolysis is defined as a defect in the pars interarticularis without vertebral slipping (summary by Wiltse et al., 1975). (184200) (Updated 20-May-2021)

MalaCards based summary : Spondylolisthesis is related to spondylolysis and spinal stenosis, and has symptoms including back pain An important gene associated with Spondylolisthesis is BMP7 (Bone Morphogenetic Protein 7), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Pregabalin and Parathyroid hormone have been mentioned in the context of this disorder. Affiliated tissues include set of vertebrae, bone and spinal cord, and related phenotypes are spondylolysis and spondylolisthesis at l5-s1

Disease Ontology : 12 A bone structure disease that has material basis in displacement located in set of vertebrae.

Wikipedia : 73 Spondylolisthesis is the displacement of one spinal vertebra compared to another. While some medical... more...

Related Diseases for Spondylolisthesis

Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
# Related Disease Score Top Affiliating Genes
1 spondylolysis 31.6 GDF5 BMP7 BMP2 ACAN
2 spinal stenosis 31.4 MMP3 COL9A3 BMP7 ACAN
3 radiculopathy 31.1 TAC1 BMP2 ACAN
4 cauda equina syndrome 30.9 CRP BMP2
5 degenerative disc disease 30.5 MMP3 GDF5 COL9A3 BMP2 ACAN
6 exostosis 30.5 GDF5 BMP2 ACAN
7 discitis 30.4 CRP ACAN
8 spondylosis 30.3 PTH ESR1 CRP BMP2 ACAN
9 osteoarthritis 30.1 PTGS2 MMP3 GDF5 CRP ACAN
10 arthropathy 30.1 PTGS2 MMP3 CRP ACAN
11 brittle bone disorder 30.0 PTH BMP7 BMP2 ACAN
12 arachnoiditis 29.8 TAC1 CRP
13 synovitis 29.8 MMP3 CRP ACAN
14 arthritis 29.7 PTH PTGS2 MMP3 CRP ACAN
15 enthesopathy 29.6 PTH CRP ACAN
16 osteoporosis 29.6 PTH PTGS2 MMP3 ESR1 CRP BMP2
17 vascular disease 29.6 PTH PTGS2 MMP3 CRP
18 osteonecrosis 29.5 PTH ESR1 BMP7 BMP2
19 bone resorption disease 29.5 PTH ESR1 CRP BMP2
20 osteochondritis dissecans 29.4 MMP3 COL9A3 BMP7 BMP2 ACAN
21 rheumatoid arthritis 29.3 PTH PTGS2 MMP3 CRP ACAN
22 constipation 29.2 TAC1 PTH PTGS2 CRP
23 jaffer beighton syndrome 11.0
24 back pain 10.9
25 scoliosis 10.7
26 neural tube defects 10.4
27 pik3ca-related overgrowth syndrome 10.4
28 intermittent claudication 10.4
29 idiopathic scoliosis 10.3
30 spina bifida occulta 10.3
31 spinal disease 10.3
32 brachydactyly, type a1, b 10.3 GDF5 BMP2
33 tenosynovitis 10.3 MMP3 CRP
34 calcific tendinitis 10.3 CRP BMP2
35 coronary aneurysm 10.3 MMP3 CRP
36 perforated corneal ulcer 10.2 MMP3 CRP
37 polykaryocytosis inducer 10.2
38 heart aneurysm 10.2 MMP3 CRP
39 active peptic ulcer disease 10.2 PTGS2 CRP
40 chondromalacia 10.2 CRP ACAN
41 vaginal discharge 10.2 ESR1 CRP
42 gingival recession 10.2 CRP BMP2
43 orbital plasma cell granuloma 10.2 PIK3C2A CRP
44 chronic orbital inflammation 10.2 PIK3C2A CRP
45 proximal symphalangism 10.2 GDF5 BMP7 BMP2
46 pyomyositis 10.2 PIK3C2A CRP
47 brachydactyly, type a2 10.2 GDF5 BMP7 BMP2
48 body mass index quantitative trait locus 1 10.2
49 paresthesia 10.2
50 ornithosis 10.2 PIK3C2A CRP

Graphical network of the top 20 diseases related to Spondylolisthesis:

Diseases related to Spondylolisthesis

Symptoms & Phenotypes for Spondylolisthesis

Human phenotypes related to Spondylolisthesis:

# Description HPO Frequency HPO Source Accession
1 spondylolysis 31 HP:0003304
2 spondylolisthesis at l5-s1 31 HP:0008489

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
spondylolisthesis of l5 on s1
defects in posterior spinous processes of l5 and sacrum

Clinical features from OMIM®:

184200 (Updated 20-May-2021)

UMLS symptoms related to Spondylolisthesis:

back pain

MGI Mouse Phenotypes related to Spondylolisthesis:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 BMP2 BMP7 COL9A3 CRP ESR1 PIK3C2A
2 immune system MP:0005387 9.85 BMP2 BMP7 COL9A3 CRP ESR1 MMP3
3 limbs/digits/tail MP:0005371 9.43 BMP2 BMP7 ESR1 GDF5 PTH PTP4A2
4 reproductive system MP:0005389 9.23 BMP2 BMP7 COL9A3 ESR1 GDF5 PTGS2

Drugs & Therapeutics for Spondylolisthesis

Drugs for Spondylolisthesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
7 Neurotransmitter Agents Phase 4
8 Psychotropic Drugs Phase 4
9 Hormones Phase 4
10 Anticonvulsants Phase 4
11 calcium channel blockers Phase 4
12 Anti-Anxiety Agents Phase 4
13 Calcium, Dietary Phase 4
14 Anesthetics, General Phase 4
15 Anesthetics, Intravenous Phase 4
16 Excitatory Amino Acid Antagonists Phase 4
17 Anesthetics, Dissociative Phase 4
18 Anesthetics Phase 4
19 Anesthetics, Local Phase 4
20 Pharmaceutical Solutions Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 113775-47-6 68602 5311068
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
Racepinephrine Approved Phase 3 329-65-7 838
Ropivacaine Approved Phase 3 84057-95-4 71273 175805
Teicoplanin Approved, Investigational Phase 3 61036-62-2
27 Hypnotics and Sedatives Phase 2, Phase 3
28 Epinephryl borate Phase 3
29 Adrenergic alpha-Agonists Phase 3
30 Adrenergic Agents Phase 3
31 Adrenergic Agonists Phase 3
32 Anti-Asthmatic Agents Phase 3
33 Adrenergic beta-Agonists Phase 3
34 Vasoconstrictor Agents Phase 3
35 Mydriatics Phase 3
36 Sympathomimetics Phase 3
37 Bronchodilator Agents Phase 3
38 Anti-Bacterial Agents Phase 3
39 Antibiotics, Antitubercular Phase 3
40 Anti-Infective Agents Phase 3
Dimethyl sulfoxide Approved, Vet_approved Phase 1, Phase 2 67-68-5 679
Remifentanil Approved Phase 2 132875-61-7 60815
Cisatracurium Approved Phase 2 96946-41-7 62887
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
Oxycodone Approved, Illicit, Investigational Phase 1 76-42-6 5284603
Acetaminophen Approved Phase 1 103-90-2 1983
Guaifenesin Approved, Investigational, Vet_approved Phase 1 93-14-1 3516
Methadone Approved Phase 1 76-99-3 4095

Interventional clinical trials:

(show top 50) (show all 185)
# Name Status NCT ID Phase Drugs
1 Interbody Fusion and Decompression Versus Instrumented Posterolateral Fusion and Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Unknown status NCT01921530 Phase 4
2 A Prospective, Multi-Center, Post-Market Surveillance Study to Assess the Clinical Efficacy and Fusion Rates of the Zimmer TM Ardis Interbody Fusion System Completed NCT02429908 Phase 4
3 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Degenerative Spondylolisthesis (DS) With Spinal Stenosis (SpS) at L4/L5 Level. Completed NCT00000409 Phase 4
4 A Consecutive Case Series of One-Level Lumbar Fusions With Pedicle Screw Instrumentation and the Trabecular Metal™ Intervertebral Cage Using Roentgen Stereophotogrammetric Analysis (RSA) Completed NCT00493558 Phase 4
5 Effect of Pregabalin on Immediate Post-operative and Longterm Pain and Spinal Cord Monitoring in Children Undergoing Instrumented Spinal Surgery. Completed NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
6 Assessment of the Efficacy of Forteo (Teriparatide) in Patients Undergoing Posterolateral Lumbar Spinal Fusion Completed NCT01292252 Phase 4
7 Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents Completed NCT01325493 Phase 4 Ketamine;Normal Saline
8 Clinical and Radiographic Outcomes of BIO4 Bone Matrix in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery Completed NCT03077204 Phase 4
9 Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation Recruiting NCT03745040 Phase 4 Liposomal bupivacaine
10 Intraoperative Methadone for Postoperative Pain Management in Spinal Fusion Surgery: a Prospective, Double-blind, Randomised Controlled Trial Recruiting NCT04764825 Phase 4 Methadone;Morphine
11 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
12 Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study Terminated NCT03514277 Phase 4 Exparel;Bupivacaine
13 Lumbar Interbody Fusion Using The Telamon® Peek™ Versus The Telamon® Hydrosorb™ Fusion Device - A Prospective, Randomized Controlled Trial To Assess Surgical And Clinical Outcomes Terminated NCT00095095 Phase 4
14 Efficacy Study Using Solum IV, Bone Marrow Concentrate With General Fluid Concentrate in Transforaminal Lumbar Interbody Fusion Withdrawn NCT03223701 Phase 4
15 A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis Unknown status NCT00418197 Phase 3
16 Immune Effect of Dexmedetomidine as Immunomodulatory Anesthesic Agent in Patients Undergoing to Spinal Fusion: a Double-blind, Randomized and Placebo-controlled Clinical Trial Unknown status NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo
17 Greenwich Lumbar Stenosis SLIP Study: A Multi-center, Randomized, Prospective Clinical Trial Comparing Spinal Laminectomy to Laminectomy With Instrumented Pedicle Screw Fusion for Lumbar Stenosis With Grade I Spondylolisthesis Completed NCT00109213 Phase 3
18 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
19 A Prospective, Multi-Center Clinical Study to Assess the Saftey and Effectiveness of the Impliant TOPS System Completed NCT00405691 Phase 3
20 Efficacy of Peri-Incisional Multimodal Drug Injection in Reducing Post-Operative Pain Following Lumbar Spine Surgery Recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
21 Does Teicoplanin Powder Use In Lumbar Instrumentation Surgery Reduce Surgical Site Infection Not yet recruiting NCT04341831 Phase 3 Teicoplanin
22 A Prospective, Multi-center, Pivotal Trial for INFUSE® Bone Graft With CAPSTONE® Spinal System and Posterior Supplemental Fixation to Treat 1- or 2-level Advanced Degenerative Disease of the Lumbosacral Spine For a TLIF Approach Terminated NCT01415908 Phase 3
23 A Clinical Study of the Dynesys(R) Spinal System As a Non-fusion Device for Spinal Stabilization Terminated NCT00759057 Phase 3
24 A Multi-Center, Prospective, Parallel Group, Randomized, Pilot Study Evaluating Safety and Preliminary Effectiveness Of Prefix Compared To Iliac Crest Bone In Subjects With DDD Undergoing Transforaminal Lumbar Interbody Fusion Unknown status NCT00798902 Phase 1, Phase 2
25 A Multi-Center, Prospective, Parallel Group, Randomized, Pilot Study Evaluating Safety and Preliminary Effectiveness Of Prefix Compared To Iliac Crest Bone In Subjects With DDD Undergoing Transforaminal Lumbar Interbody Fusion Unknown status NCT00798239 Phase 1, Phase 2
26 "Ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue for Spinal Fusion in Spine Degenerative Disease Completed NCT01552707 Phase 1, Phase 2
27 A Dose-escalation Study to Assess the Feasibility and Safety of 3 Different Doses of NeoFuse When Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion With Instrumentation. Completed NCT00549913 Phase 1, Phase 2
28 A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Lumbar Interbody Fusion With Instrumentation Completed NCT00996073 Phase 2
29 Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation Completed NCT01106417 Phase 1, Phase 2
30 Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation Completed NCT01097486 Phase 2
31 Transverse Abdominis Plane Block for Anterior Approach Spine Surgery: A Prospective Randomized Study Completed NCT02884440 Phase 2 TAP block ropivacaine;TAP block placebo;General anesthesia
32 A Phase 1b/2a Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion Recruiting NCT04378543 Phase 1, Phase 2
33 A Prospective Multi-centre, Randomised, Controlled Study to Evaluate the Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis by Interbody Fusion (L1 - S1) Active, not recruiting NCT03100032 Phase 1, Phase 2
34 A Prospective Study Assessing Clinical Outcomes and Radiographic Results After the Use of CopiOs(R) Bone Void Filler (BVF)Sponge in a Posterolateral Fusion Procedure (PLF). Terminated NCT01123850 Phase 2
35 A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With Mastergraft Granules in Subjects Undergoing Posterolateral Lumbar Fusion With Instrumentation Withdrawn NCT00810212 Phase 1, Phase 2
36 First-In-Human Study of AK1320 Encapsulated Microspheres (AK1320 MS) In Subjects With Degenerative Spondylolisthesis and Concomitant Symptomatic Spinal Stenosis Who Are Undergoing Decompression And Single Level Instrumented Posterolateral Lumbar Autograft Fusion Surgery Recruiting NCT04483297 Phase 1 AK1320 MS
37 Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions: A Randomized, Double-blinded, Controlled Trial Not yet recruiting NCT04112550 Phase 1 Methadone Hydrochloride;Oxycodone-Acetaminophen
38 Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression (STRiDE) Unknown status NCT01338766
39 Supine vs. Upright Weight Bearing MRI in the Evaluation of Patients With Lumbar Spondylolisthesis Unknown status NCT02958241
40 LIFT: Luna Interbody System for Fusion Trial Unknown status NCT01551901
41 Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study. Unknown status NCT03407560
42 Clinical Trial of the Efficacy of Hybrid Systems(Topping Off)in Comparison to the Conventional Spondylodesis in Fusion-surgery in the Lumbal Spine: a Prospective, Randomised Study Unknown status NCT01224379
43 A Pilot Clinical Study to Assess the Safety and Effectiveness of the InterCushion Disc Nucleus Prosthesis in Patients Receiving Discectomy Unknown status NCT01652053
44 A Pilot Study Comparing Midline Versus Paramedian Approaches to the Lumbar Spine for Single- or Two-Level Fusions in Degenerative Spondylolisthesis Unknown status NCT03344484
45 The Rehabilitation Outcome of Patients With Lumbar Spondylolisthesis. A Prospective Randomized Study Unknown status NCT02435485
46 Prospective Study of Minimally Invasive Spinal Fusion Surgery for the Treatment of Spondylolisthesis, Degenerative Disk Disease, Spinal Stenosis and Degenerative Scoliosis Unknown status NCT01045473
47 A Multi-Center Prospective Study of Vertebral Technologies, Inc. (VTI) InterFuse® S and InterFuse® T for the Treatment of Scoliosis, Spondylolisthesis and Degenerative Disc Disease. Unknown status NCT02659722
48 Minimal Access Midline Lumbar Fusion Versus Traditional Open Posterior Lumbar Interbody Fusion for Degenerative Lumbar Spondylolisthesis Unknown status NCT02290314
49 Clinical Study of Bilateral Decompression With Interbody Fusion for Spondylolisthesis Unknown status NCT02972190
50 Comparison of Radiologic and Clinical Outcome of Single Level Lumbar Interbody Fusion Between Unilateral or Bilateral Facetectomy : Prospective Randomized Controlled Trial Unknown status NCT03856554

Search NIH Clinical Center for Spondylolisthesis

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spondylolisthesis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondylolisthesis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spondylolisthesis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spondylolisthesis

Genetic Tests for Spondylolisthesis

Anatomical Context for Spondylolisthesis

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolisthesis:

Set Of Vertebrae

MalaCards organs/tissues related to Spondylolisthesis:

Bone, Spinal Cord, Bone Marrow, Kidney, Colon, Dorsal Root Ganglion, Heart

Publications for Spondylolisthesis

Articles related to Spondylolisthesis:

(show top 50) (show all 5320)
# Title Authors PMID Year
Familial spondylolisthesis of the axis vertebra. 61 57
3536939 1986
Family study of spondylolysis and spondylolisthesis. 57 61
6761366 1982
A family with spondylolisthesis. 57 61
511891 1979
Familial occurrence of lumbar spondylolysis and spondylolisthesis. 57 61
668183 1978
Fatigue fracture: the basic lesion is inthmic spondylolisthesis. 57 61
1123367 1975
A family with spondylolisthesis. 57 61
5413907 1970
Hereditary spondylolisthesis and spina bifida. Report of a family in which the lesion is transmitted as an autosomal dominant through three generations. 57 61
5336847 1967
The etiology of spondylolisthesis. 61 57
14040287 1962
Examination of the possibility that certain skeletal characters predispose to defects in the lumbar neural arches. 57
13374901 1956
[The age incidence of neural-arch defects in Alaskan natives, considered from the standpoint of etiology]. 57
13108895 1953
A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 61 54
15672240 2005
A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. 54 61
15534410 2004
A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 61 54
12908103 2003
Effect of Dorsal Root Ganglion Retraction in Endoscopic Lumbar Decompressive Surgery for Foraminal Pathology: A Retrospective Cohort Study of Interlaminar Contralateral Endoscopic Lumbar Foraminotomy and Discectomy versus Transforaminal Endoscopic Lumbar Foraminotomy and Discectomy. 61
33444831 2021
An Unusual Pattern of Premature Cervical Spine Degeneration in STAT3-LOF. 61
33404973 2021
A comparison of successful versus failed nonoperative treatment approaches in patients with degenerative conditions of the lumbar spine. 61
33775350 2021
Ten-Year Long-term Results of Modified Cervical Double-door Laminoplasty With C3 Laminectomy Preserving the Semispinalis Cervicis Inserted Into the Axis Compared With Those of Conventional Cervical Laminoplasty. 61
32941312 2021
[Case report of an osseous (and lymphogenic) thymic carcinoma in an adult]. 61
32350550 2021
Is There Additional Value to Flexion-Extension Radiographs for Degenerative Spondylolisthesis? 61
33181769 2021
Transforaminal lumbar interbody fusion with reduction of slippage of vertebrae for isthmic lumbar spondylolisthesis: Unilateral versus bilateral interbody fusion. 61
33721658 2021
Association between the appropriateness of surgery, according to appropriate use criteria, and patient-rated outcomes after surgery for lumbar degenerative spondylolisthesis. 61
33575818 2021
Stabilization Exercises Versus Flexion Exercises in Degenerative Spondylolisthesis: A Randomized Controlled Trial. 61
33792726 2021
Utility of Natural Sitting Lateral Radiograph in the Diagnosis of Segmental Instability for Patients with Degenerative Lumbar Spondylolisthesis. 61
33165051 2021
C2-C3 vertebral disc angle: an analysis of patients with and without cervical spondylotic myelopathy. 61
33757775 2021
The technical feasibility and preliminary results of minimally invasive endoscopic-TLIF based on electromagnetic navigation: a case series. 61
33743668 2021
Inclusion of L5-S1 in oblique lumbar interbody fusion-techniques and early complications-a single center experience. 61
33091611 2021
The erector spinae plane block for analgesia after lumbar spine surgery: A systematic review. 61
33716419 2021
Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies. 61
33807361 2021
MIS-TLIF versus O-TLIF for single-level degenerative stenosis: study protocol for randomised controlled trial. 61
33674366 2021
The association between continuity of care and surgery in lumbar disc herniation patients. 61
33692399 2021
Facet Tropism in Lumbar Spine and Cervical Spine: A Systematic Review and Meta-Analysis. 61
33309642 2021
A novel dataset and deep learning-based approach for marker-less motion capture during gait. 61
33711613 2021
Comparative Demographics and Outcomes of Minimally Invasive Transforaminal Lumbar Interbody Fusion in Chinese, Malays, and Indians. 61
33633059 2021
Risk Factors and Scoring System of Cage Retropulsion after Posterior Lumbar Interbody Fusion: A Retrospective Observational Study. 61
33749137 2021
Comparison of Minimal Invasive Versus Biportal Endoscopic Transforaminal Lumbar Interbody Fusion for Single-level Lumbar Disease. 61
33633061 2021
Lumbar endoscopic unilateral laminotomy for bilateral decompression for lumbar spinal stenosis provides comparable clinical outcomes in patients with and without degenerative spondylolisthesis. 61
33722714 2021
Overreporting of the disc herniation in lumbar spine MRI scans performed for patients with spondylolisthesis. 61
32438875 2021
Management of Degenerative Spondylolisthesis: Development of Appropriate Use Criteria. 61
33689838 2021
Spontaneous intracranial hypotension and lumbosacral spondylolisthesis-case report of a rare association. 61
33493877 2021
Is stand-alone lateral lumbar interbody fusion superior to instrumented lateral lumbar interbody fusion for the treatment of single-level, low-grade, lumbar spondylolisthesis? 61
33581796 2021
Bone Formation During Correction of Vertebral Rounding Deformity in a Rat Model of Pediatric Spondylolisthesis. 61
33156272 2021
What is the Optimal Surgical Method for Achieving Correction and Avoiding Neurological Complications in Pediatric High-grade Spondylolisthesis? 61
33165266 2021
Customised hybrid CT-MRI 3D-printed model for grade V spondylolisthesis in an adolescent. 61
33649040 2021
Effects and Safety of Lumbar Fusion Techniques in Lumbar Spondylolisthesis: A Network Meta-Analysis of Randomized Controlled Trials. 61
33752459 2021
Effect of Minimally Invasive Selective Laminectomy for Cervical Spondylotic Myelopathy on Degenerative Spondylolisthesis. 61
33769983 2021
Is there a place for surgical repair in adults with spondylolysis or grade-I spondylolisthesis-A systematic review and treatment algorithm. 61
33757872 2021
Adjacent Segment Pathology following Posterior Lumbar Interbody Fusion for Lumbar Degenerative Spondylolisthesis: A Comparison between Minimally Invasive and Conventional Open Approach. 61
33785474 2021
Clinical Comparison of Combined Cortical Bone Trajectory and Transarticular Surface Screw Versus Standard Pedicle Screw Insertion by Wiltse Approach for L5 Isthmic Spondylolisthesis. 61
33769975 2021
Health-related quality of life and sagittal balance at two to 25 years after posterior transfixation for high-grade dysplastic spondylolisthesis. 61
33677995 2021
Different Types of Double-Level Degenerative Lumber Spondylolisthesis: What Is Different in the Sagittal Plane? 61
33684582 2021

Variations for Spondylolisthesis

Expression for Spondylolisthesis

Search GEO for disease gene expression data for Spondylolisthesis.

Pathways for Spondylolisthesis

GO Terms for Spondylolisthesis

Cellular components related to Spondylolisthesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 TAC1 PTH MMP3 GDF5 CRP COL9A3
2 extracellular region GO:0005576 9.32 TAC1 SMR3A PTH MMP3 GDF5 CRP

Biological processes related to Spondylolisthesis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.9 TAC1 PTGS2 CRP BMP2
2 cell-cell signaling GO:0007267 9.8 TAC1 PTH GDF5 BMP2
3 response to estradiol GO:0032355 9.75 PTGS2 ESR1 BMP7
4 positive regulation of neuron differentiation GO:0045666 9.73 GDF5 BMP7 BMP2
5 BMP signaling pathway GO:0030509 9.71 GDF5 BMP7 BMP2
6 cartilage development GO:0051216 9.69 GDF5 BMP7 BMP2
7 SMAD protein signal transduction GO:0060395 9.63 GDF5 BMP7 BMP2
8 steroid hormone mediated signaling pathway GO:0043401 9.61 ESR1 BMP7
9 negative regulation of chondrocyte differentiation GO:0032331 9.59 PTH GDF5
10 positive regulation of brown fat cell differentiation GO:0090336 9.58 PTGS2 BMP7
11 negative regulation of calcium ion transport GO:0051926 9.57 PTH PTGS2
12 regulation of neuroinflammatory response GO:0150077 9.55 PTGS2 MMP3
13 negative regulation of cell cycle GO:0045786 9.54 PTGS2 BMP7 BMP2
14 mesenchymal cell differentiation GO:0048762 9.52 BMP7 BMP2
15 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.5 GDF5 BMP7 BMP2
16 endocardial cushion formation GO:0003272 9.48 BMP7 BMP2
17 skeletal system development GO:0001501 9.46 PTH BMP7 BMP2 ACAN
18 mesenchyme development GO:0060485 9.43 BMP7 BMP2
19 positive regulation of bone mineralization GO:0030501 9.43 PTH BMP7 BMP2
20 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.4 ESR1 BMP7
21 response to vitamin D GO:0033280 9.13 PTH PTGS2 BMP7
22 positive regulation of ossification GO:0045778 8.8 TAC1 PTH BMP2

Molecular functions related to Spondylolisthesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BMP receptor binding GO:0070700 8.62 BMP7 BMP2

Sources for Spondylolisthesis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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