Aliases & Classifications for Spondylolisthesis

MalaCards integrated aliases for Spondylolisthesis:

Name: Spondylolisthesis 57 38 12 29 55 44 15 73

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
spondylolisthesis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 184200
Disease Ontology 12 DOID:6682
ICD10 33 M43.1 M43.10
MeSH 44 D013168
NCIt 50 C35033
MedGen 42 C0038016
SNOMED-CT via HPO 69 263681008 240221008
UMLS 73 C0038016

Summaries for Spondylolisthesis

OMIM : 57 Spondylolisthesis is defined as forward slipping of a vertebral body on the one below it. Spondylolysis is defined as a defect in the pars interarticularis without vertebral slipping (summary by Wiltse et al., 1975). (184200)

MalaCards based summary : Spondylolisthesis is related to spondylolysis and spinal stenosis, and has symptoms including back pain An important gene associated with Spondylolisthesis is BMP7 (Bone Morphogenetic Protein 7), and among its related pathways/superpathways are GPCR Pathway and p70S6K Signaling. The drugs Ketamine and Teriparatide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and testes, and related phenotypes are spondylolysis and spondylolisthesis at l5-s1

Disease Ontology : 12 A bone structure disease that has material basis in displacement located in set of vertebrae.

Wikipedia : 76 Spondylolisthesis is the slippage or displacement of one vertebra compared to another. Spondylolisthesis... more...

Related Diseases for Spondylolisthesis

Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 spondylolysis 31.4 GDF5 FTH1 BMP7
2 spinal stenosis 31.2 MMP3 BMP7
3 degenerative disc disease 30.5 GDF5 BMP2
4 osteoarthritis 30.3 PTGS2 MMP3 GDF5
5 pseudoarthrosis 30.2 BMP7 BMP2
6 jaffer beighton syndrome 11.1
7 scoliosis 10.5
8 idiopathic scoliosis 10.2
9 spondylosis 10.2
10 radiculopathy 10.2
11 frozen shoulder 10.2 MMP3 GDF5
12 endometrial disease 10.2 PTGS2 ESR1
13 neural tube defects 10.2
14 spina bifida occulta 10.2
15 cardiomyopathy, familial hypertrophic, 9 10.2 FTH1 ESR1
16 proximal symphalangism 10.1 GDF5 BMP7
17 osteochondritis dissecans 10.1 MMP3 BMP7
18 rheumatoid arthritis 10.1
19 arthritis 10.1
20 discitis 10.1
21 oral submucous fibrosis 10.1 PTGS2 MMP3
22 osseous heteroplasia, progressive 10.1 BMP7 BMP2
23 polykaryocytosis inducer 10.0
24 scoliosis, isolated 1 10.0
25 brittle bone disorder 10.0
26 cauda equina syndrome 10.0
27 bone resorption disease 10.0 ESR1 BMP2
28 polyradiculopathy 10.0 IVD BMP2
29 juvenile polyposis syndrome 10.0 PTGS2 BMP2
30 adenomyosis 10.0 PTGS2 ESR1
31 bone remodeling disease 10.0 ESR1 BMP2
32 brachydactyly, type a2 10.0 MMP3 GDF5 BMP2
33 osteoporosis 10.0
34 opiate dependence 10.0
35 spondylitis 10.0
36 depression 10.0
37 coronary artery aneurysm 10.0 PRRC2A MMP3
38 cervical adenocarcinoma 9.9 PTGS2 ESR1
39 basal cell nevus syndrome 9.8
40 legg-calve-perthes disease 9.8
41 torticollis 9.8
42 down syndrome 9.8
43 pycnodysostosis 9.8
44 mucopolysaccharidosis, type ii 9.8
45 intervertebral disc disease 9.8
46 basal cell carcinoma 1 9.8
47 body mass index quantitative trait locus 1 9.8
48 anxiety 9.8
49 chromosome 16p13.3 deletion syndrome, proximal 9.8
50 bone mineral density quantitative trait locus 15 9.8

Graphical network of the top 20 diseases related to Spondylolisthesis:



Diseases related to Spondylolisthesis

Symptoms & Phenotypes for Spondylolisthesis

Symptoms via clinical synopsis from OMIM:

57
Spine:
spondylolysis
spondylolisthesis of l5 on s1
defects in posterior spinous processes of l5 and sacrum


Clinical features from OMIM:

184200

Human phenotypes related to Spondylolisthesis:

32
# Description HPO Frequency HPO Source Accession
1 spondylolysis 32 HP:0003304
2 spondylolisthesis at l5-s1 32 HP:0008489

UMLS symptoms related to Spondylolisthesis:


back pain

GenomeRNAi Phenotypes related to Spondylolisthesis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.58 PTGS2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.58 PTGS2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.58 PTGS2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.58 IVD
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.58 IDS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.58 IDS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.58 IDS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 IDS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.58 IDS IVD PTGS2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 IDS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.58 IDS PTGS2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.58 IDS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.58 PTGS2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.58 IDS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.58 PTGS2

MGI Mouse Phenotypes related to Spondylolisthesis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 BMP2 BMP7 ESR1 FTH1 IDS MMP3
2 homeostasis/metabolism MP:0005376 10.03 BMP2 ESR1 FTH1 IDS IVD MMP3
3 immune system MP:0005387 9.95 BMP2 BMP7 ESR1 FTH1 IDS MMP3
4 mortality/aging MP:0010768 9.91 BMP2 BMP7 ESR1 FTH1 GDF5 IDS
5 limbs/digits/tail MP:0005371 9.77 BMP2 BMP7 ESR1 GDF5 IDS
6 nervous system MP:0003631 9.76 BMP2 BMP7 ESR1 FTH1 IDS MMP3
7 liver/biliary system MP:0005370 9.72 ESR1 FTH1 IDS PROS1 PTGS2
8 reproductive system MP:0005389 9.43 BMP2 BMP7 ESR1 GDF5 IDS PTGS2
9 skeleton MP:0005390 9.17 BMP2 BMP7 ESR1 GDF5 IDS MMP3

Drugs & Therapeutics for Spondylolisthesis

Drugs for Spondylolisthesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
2
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
3
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
4
Pregabalin Approved, Illicit, Investigational Phase 4,Not Applicable 148553-50-8 5486971
5
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
6
s 1 (combination) Phase 4,Phase 1,Phase 2,Not Applicable
7 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
8 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
9 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
10 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
11 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
12 Calcium, Dietary Phase 4,Phase 2,Not Applicable
13 Anesthetics, General Phase 4,Not Applicable
14 Anesthetics, Dissociative Phase 4
15 Excitatory Amino Acid Antagonists Phase 4
16 Narcotics Phase 4,Phase 3,Not Applicable
17 Anesthetics, Intravenous Phase 4
18 Excitatory Amino Acids Phase 4
19 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
20 Hormones Phase 4
21 Bone Density Conservation Agents Phase 4
22 Psychotropic Drugs Phase 4
23 calcium channel blockers Phase 4
24 Anti-Anxiety Agents Phase 4
25 Tranquilizing Agents Phase 4
26 Anticonvulsants Phase 4
27 Pharmaceutical Solutions Phase 4
28 Anesthetics, Local Phase 4,Phase 3,Phase 2
29
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 113775-47-6 68602 5311068
30
Racepinephrine Approved Phase 3,Not Applicable 329-65-7 838
31
Morphine Approved, Investigational Phase 3,Not Applicable 57-27-2 5288826
32
Epinephrine Approved, Vet_approved Phase 3,Not Applicable 51-43-4 5816
33
Ropivacaine Approved Phase 3,Phase 2 84057-95-4 175805 71273
34 Analgesics, Non-Narcotic Phase 2, Phase 3
35 Adrenergic alpha-Agonists Phase 2, Phase 3,Phase 3
36 Adrenergic alpha-2 Receptor Agonists Phase 2, Phase 3
37 Adrenergic Agonists Phase 2, Phase 3,Phase 3
38 Hypnotics and Sedatives Phase 2, Phase 3
39 Adrenergic Agents Phase 2, Phase 3,Phase 3
40 Epinephryl borate Phase 3,Not Applicable
41 Anti-Asthmatic Agents Phase 3
42 Mydriatics Phase 3
43 Adrenergic beta-Agonists Phase 3
44 Bronchodilator Agents Phase 3
45 Respiratory System Agents Phase 3
46 Vasoconstrictor Agents Phase 3
47 Sympathomimetics Phase 3
48 Autonomic Agents Phase 3
49
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2,Not Applicable 1177-87-3
50
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Not Applicable 50-02-2 5743

Interventional clinical trials:

(show top 50) (show all 160)
# Name Status NCT ID Phase Drugs
1 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Unknown status NCT02429908 Phase 4
2 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
3 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
4 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
5 Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion Completed NCT01292252 Phase 4
6 Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis Completed NCT00000411 Phase 4
7 Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation Completed NCT00000410 Phase 4
8 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
9 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
10 A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
11 BIO4 Clinical Case Study: Cervical Spine Active, not recruiting NCT03077204 Phase 4
12 Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion Not yet recruiting NCT03745040 Phase 4 Liposomal bupivacaine
13 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
14 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
15 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis Unknown status NCT01618435 Phase 3
16 Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion Unknown status NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo
17 Total Facet Arthroplasty System®(TFAS®) Clinical Trial Unknown status NCT00418197 Phase 3
18 Greenwich Lumbar Stenosis SLIP Study Completed NCT00109213 Phase 3
19 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
20 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
21 Peri-Incisional Drug Injection in Lumbar Spine Surgery Not yet recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
22 A Clinical Study of the Dynesys(R) Spinal System Terminated NCT00759057 Phase 3
23 INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine Terminated NCT01415908 Phase 3
24 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
25 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
26 Efficacy and Safety Study of Lumbar Interbody Fusion With MatriTMBONE Associated With Autologous Bone Marrow Unknown status NCT01335243 Phase 2
27 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion Completed NCT00996073 Phase 2
28 Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion Completed NCT01106417 Phase 2
29 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy Completed NCT01097486 Phase 2
30 Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF) Completed NCT00549913 Phase 1, Phase 2
31 Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis Recruiting NCT03100032 Phase 1, Phase 2
32 Transverse Abdominis Plane Block for Anterior Approach Spine Surgery Recruiting NCT02884440 Phase 2 TAP block ropivacaine;TAP block placebo;General anesthesia
33 Safety Study of Mesenchymal Stem Cells and Spinal Fusion Active, not recruiting NCT01552707 Phase 1, Phase 2
34 Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion Active, not recruiting NCT02205138 Phase 2 ALLOB® cells with ceramic scaffold
35 CopiOs Posterolateral Fusion Procedure Terminated NCT01123850 Phase 2
36 Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion Withdrawn NCT00810212 Phase 1, Phase 2
37 Supine vs. Upright Weight Bearing MRI in the Evaluation of Patients With Lumbar Spondylolisthesis Unknown status NCT02958241 Not Applicable
38 Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression Unknown status NCT01338766 Not Applicable
39 InterFuse® S and T for the Treatment of Scoliosis, Spondylolisthesis and Degenerative Disc Disease (DDD) Unknown status NCT02659722
40 Prospective Study of Minimally Invasive Spine Surgery Unknown status NCT01045473
41 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379 Not Applicable
42 Post-market Study of the TOPS™ System Unknown status NCT02234154 Not Applicable
43 Post-market Study of the TOPS™ System Unknown status NCT01933607 Not Applicable
44 Post-market Surveillance Study of FLXfit™ TLIF Interbody Fusion Device Unknown status NCT02805985 Not Applicable
45 Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain Unknown status NCT01918943
46 Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures Unknown status NCT02171169
47 Efficacy Study of Acupuncture to Treat Spinal Pain Unknown status NCT01909284 Not Applicable
48 Physical Therapy Management in Degenerative Lumbar Diseases and Osteoporosis Unknown status NCT01703403
49 Luna Interbody System for Fusion Trial Unknown status NCT01551901 Not Applicable
50 A Pilot Study of the InterCushion Disc Nucleus Prosthesis (DNP) in Patients Receiving Discectomy Unknown status NCT01652053

Search NIH Clinical Center for Spondylolisthesis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spondylolisthesis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondylolisthesis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spondylolisthesis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spondylolisthesis

Genetic Tests for Spondylolisthesis

Genetic tests related to Spondylolisthesis:

# Genetic test Affiliating Genes
1 Spondylolisthesis 29

Anatomical Context for Spondylolisthesis

MalaCards organs/tissues related to Spondylolisthesis:

41
Bone, Bone Marrow, Testes, Spinal Cord, Colon

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolisthesis:

19
Set Of Vertebrae

Publications for Spondylolisthesis

Articles related to Spondylolisthesis:

(show top 50) (show all 1297)
# Title Authors Year
1
Natural History of Cervical Degenerative Spondylolisthesis. ( 29952882 )
2018
2
The Challenge of Creating Lordosis in High-Grade Dysplastic Spondylolisthesis. ( 29933805 )
2018
3
Motion Analysis in Lumbar Spinal Stenosis With Degenerative Spondylolisthesis: A Feasibility Study of the 3DCT Technique Comparing Laminectomy Versus Bilateral Laminotomy. ( 29939843 )
2018
4
Posterolateral fusion (PLF) vs. transforaminal lumbar interbody fusion (TLIF) for spondylolisthesis: a systematic review and meta-analysis. ( 29452283 )
2018
5
Decompression with or without concomitant fusion in lumbar stenosis due to degenerative spondylolisthesis: a systematic review. ( 29404693 )
2018
6
A novel noninstrumented surgical approach for foramen reconstruction for isthmic spondylolisthesis in patients with radiculopathy: preliminary clinical and radiographic outcomes. ( 29290136 )
2018
7
Spondylolysis and spondylolisthesis: A review of the literature. ( 29881164 )
2018
8
Reliability and Clinical Utility of the CARDS Classification for Degenerative Spondylolisthesis. ( 28719453 )
2018
9
Spondylolisthesis is Common, Early, and Severe in Loeys-Dietz Syndrome. ( 29889773 )
2018
10
Radiological and functional outcomes of high-grade spondylolisthesis treated by intrasacral fixation, dome resection and circumferential fusion: a retrospective series of 20 consecutive cases with a minimum of 2A years follow-up. ( 29353326 )
2018
11
Direction-changeable lumbar cage versus traditional lumbar cage for treating lumbar spondylolisthesis: A retrospective study. ( 29443791 )
2018
12
Mild (not severe) disc degeneration is implicated in the progression of bilateral L5 spondylolysis to spondylolisthesis. ( 29609581 )
2018
13
Evaluation of the facet joints with magnetic resonance images in the patients with disc degeneration and spondylolisthesis. ( 29909481 )
2018
14
Long-term Minimum Clinically Important Difference(MCID) in Health Related Quality of Life Scores After Instrumented Lumbar Interbody Fusion for Low-Grade Isthmic Spondylolisthesis. ( 29920389 )
2018
15
Does Surgically Managed Grade I Degenerative Lumbar Spondylolisthesis Require Fusion? ( 29975202 )
2018
16
Minimally invasive anterior and lateral transpsoas approaches for closed reduction of grade II spondylolisthesis: initial clinical and radiographic experience. ( 29290134 )
2018
17
Increased rate of lumbar spondylolisthesis in rheumatoid arthritis: a case-control study. ( 29956820 )
2018
18
Comparative Utility of Dynamic and Static Imaging in the Management of Lumbar Spondylolisthesis. ( 29929030 )
2018
19
Assessment of radiographic and clinical outcomes of an articulating expandable interbody cage in minimally invasive transforaminal lumbar interbody fusion for spondylolisthesis. ( 29290133 )
2018
20
Increased PT/SS may play an important role in the pathogenesis of lumbar spondylolisthesis with degenerative lumbar scoliosis. ( 29358108 )
2018
21
Radiographic Classification for Degenerative Spondylolisthesis of the Lumbar Spine Based on Sagittal Balance: A Reliability Study. ( 29886905 )
2018
22
Posterior reversible encephalopathy syndrome with status epilepticus following surgery for lumbar stenosis and spondylolisthesis: case report. ( 29864559 )
2018
23
L5 incidence: an important parameter for spinopelvic balance evaluation in high grade spondylolisthesis. ( 29360579 )
2018
24
Image guidance in transdiscal fixation for high-grade spondylolisthesis in adults with correct spinal balance. ( 29290127 )
2018
25
Utility of Supine Lateral Radiographs for Assessment of Lumbar Segmental Instability in Degenerative Lumbar Spondylolisthesis. ( 29432395 )
2018
26
Diagnosis of Spondylolysis and Spondylolisthesis Is Delayed Six Months After Seeing Nonorthopedic Providers. ( 29735135 )
2018
27
Transforaminal Endoscopic Decompression in the Setting of Lateral Lumbar Spondylolisthesis: Technical Note. ( 29940383 )
2018
28
The importance of proximal femoral angle on sagittal balance and quality of life in children and adolescents with high-grade lumbosacral spondylolisthesis. ( 29445950 )
2018
29
Minimally invasive transforaminal lumbar interbody fusion using bone cement-augmented pedicle screws for lumbar spondylolisthesis in patients with osteoporosis. Case series and review of literature. ( 29322970 )
2018
30
Radiological adjacent-segment degeneration in L4-5 spondylolisthesis: comparison between dynamic stabilization and minimally invasive transforaminal lumbar interbody fusion. ( 29856306 )
2018
31
A comparison of the techniques of direct pars interarticularis repairs for spondylolysis and low-grade spondylolisthesis: a meta-analysis. ( 29290131 )
2018
32
Facet Joint Osteoarthritis Affects Spinal Segmental Motion in Degenerative Spondylolisthesis. ( 29912734 )
2018
33
Current Evidence Regarding the Diagnostic Methods for Pediatric Lumbar Spondylolisthesis: A Report From the Scoliosis Research Society Evidence Based Medicine Committee. ( 29413742 )
2018
34
Current trends in the management of degenerative lumbar spondylolisthesis. ( 29951256 )
2018
35
How many physical therapy sessions are required to reach a good outcome in symptomatic lumbar spondylolisthesis? A retrospective study. ( 29332744 )
2018
36
Surgical outcomes of single-level transforaminal lumbar interbody fusion for degenerative spondylolisthesis with and without kyphotic alignment. ( 29913292 )
2018
37
Does adding interbody fusion to posterolateral fusion increase success in the surgical management of degenerative lumbar spondylolisthesis? ( 29385121 )
2018
38
Outcome of transforaminal lumbar interbody fusion in spondylolisthesis-A clinico-radiological correlation. ( 29881153 )
2018
39
Double-level lumbar spondylolysis and spondylolisthesis: A retrospective study. ( 29548343 )
2018
40
Double-level isthmic spondylolisthesis treated with posterior lumbar interbody fusion with cage. ( 29361854 )
2018
41
Factors predicting opioid dependence in patients undergoing surgery for degenerative spondylolisthesis: analysis from the MarketScan databases. ( 29914294 )
2018
42
Successful Endoscopic Surgery for L5 Radiculopathy Caused by Far-Lateral Disc Herniation at L5-S1 and L5 Isthmic Grade 2 Spondylolisthesis in a Professional Baseball Player. ( 30364859 )
2018
43
To fuse or not to fuse: a survey among members of the German Spine Society (DWG) regarding lumbar degenerative spondylolisthesis and spinal stenosis. ( 30542763 )
2018
44
Degenerative Lumbar Spondylolisthesis with Spinal Stenosis: A Comparative Study of 5-Year Outcomes Following Decompression with Fusion and Microendoscopic Decompression. ( 29503693 )
2018
45
Does Preoperative Degenerative Spondylolisthesis Influence Outcome in Degenerative Lumbar Spinal Stenosis? Three-Year Results of a Swiss Prospective Multicenter Cohort Study. ( 29626686 )
2018
46
Minimum ten-year follow-up of spinal stenosis with degenerative spondylolisthesis treated with decompression and dynamic stabilization. ( 29732428 )
2018
47
Reoperation Rate After Microsurgical Uni- or Bilateral Laminotomy for Lumbar Spinal Stenosis with and Without Low-Grade Spondylolisthesis: What do Preoperative Radiographic Parameters Tell Us? ( 30015718 )
2018
48
Minimally invasive decompression in patients with degenerative spondylolisthesis associated with lumbar spinal stenosis. Report of a surgical series and review of the literature. ( 30025719 )
2018
49
The pelvic radius technique in the assessment of spinopelvic sagittal alignment of degenerative spondylolisthesis and lumbar spinal stenosis. ( 30055879 )
2018
50
Assessing the real benefits of surgery for degenerative lumbar spinal stenosis without instability and spondylolisthesis: a single surgeon experience with a mean 8-year follow-up. ( 30171437 )
2018

Variations for Spondylolisthesis

Expression for Spondylolisthesis

Search GEO for disease gene expression data for Spondylolisthesis.

Pathways for Spondylolisthesis

GO Terms for Spondylolisthesis

Cellular components related to Spondylolisthesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 BMP2 BMP7 FTH1 GDF5 MMP3 PROS1

Biological processes related to Spondylolisthesis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.91 BMP2 FTH1 IVD PTGS2
2 negative regulation of cell proliferation GO:0008285 9.84 BMP2 BMP7 FTH1 PTGS2
3 regulation of apoptotic process GO:0042981 9.71 BMP2 BMP7 ESR1 GDF5
4 response to estradiol GO:0032355 9.7 BMP7 ESR1 PTGS2
5 positive regulation of neuron differentiation GO:0045666 9.67 BMP2 BMP7 GDF5
6 BMP signaling pathway GO:0030509 9.65 BMP2 BMP7 GDF5
7 cartilage development GO:0051216 9.63 BMP2 BMP7 GDF5
8 steroid hormone mediated signaling pathway GO:0043401 9.62 BMP7 ESR1
9 positive regulation of cell death GO:0010942 9.62 BMP7 PTGS2
10 positive regulation of cell differentiation GO:0045597 9.61 BMP2 BMP7
11 positive regulation of epithelial to mesenchymal transition GO:0010718 9.6 BMP2 BMP7
12 bone mineralization GO:0030282 9.59 BMP2 PTGS2
13 chondrocyte differentiation GO:0002062 9.58 BMP2 GDF5
14 epithelial to mesenchymal transition GO:0001837 9.58 BMP2 BMP7
15 cellular response to BMP stimulus GO:0071773 9.57 BMP2 BMP7
16 positive regulation of bone mineralization GO:0030501 9.56 BMP2 BMP7
17 response to vitamin D GO:0033280 9.55 BMP7 PTGS2
18 mesenchymal cell differentiation GO:0048762 9.51 BMP2 BMP7
19 cell development GO:0048468 9.5 BMP2 BMP7 GDF5
20 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.43 BMP7 ESR1
21 regulation of MAPK cascade GO:0043408 9.43 BMP2 BMP7 GDF5
22 mesenchyme development GO:0060485 9.37 BMP2 BMP7
23 SMAD protein signal transduction GO:0060395 9.33 BMP2 BMP7 GDF5
24 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.13 BMP2 BMP7 GDF5
25 negative regulation of cell cycle GO:0045786 8.8 BMP2 BMP7 PTGS2

Molecular functions related to Spondylolisthesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 BMP2 BMP7 GDF5
2 growth factor activity GO:0008083 9.33 BMP2 BMP7 GDF5
3 BMP receptor binding GO:0070700 8.96 BMP2 BMP7
4 transforming growth factor beta receptor binding GO:0005160 8.8 BMP2 BMP7 GDF5

Sources for Spondylolisthesis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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