Spondylolisthesis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN019 MIFTS: 51	Spondylolisthesis Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Spondylolisthesis

MalaCards integrated aliases for Spondylolisthesis:

Name: Spondylolisthesis ⁵⁶ ¹² ⁵⁴ ⁴³ ¹⁵ ³⁷ ¹⁷ ⁷¹ ³²

Characteristics:

OMIM:

⁵⁶

Inheritance:
autosomal dominant

HPO:

³¹

spondylolisthesis:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the musculoskeletal system and connective tissue

Deforming dorsopathies

Other deforming dorsopathies

Spondylolisthesis

External Ids:

Disease Ontology ¹² DOID:6682

OMIM ⁵⁶ 184200

MeSH ⁴³ D013168

NCIt ⁴⁹ C35033

SNOMED-CT ⁶⁷ 274152003

ICD10 ³² M43.1

MedGen ⁴¹ C0038016

SNOMED-CT via HPO ⁶⁸ 240221008 263681008

EFO ¹⁷ EFO_0007493

UMLS ⁷¹ C0038016

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Summaries for Spondylolisthesis

OMIM : ⁵⁶ Spondylolisthesis is defined as forward slipping of a vertebral body on the one below it. Spondylolysis is defined as a defect in the pars interarticularis without vertebral slipping (summary by Wiltse et al., 1975). (184200)

MalaCards based summary : Spondylolisthesis is related to spinal stenosis and radiculopathy, and has symptoms including back pain An important gene associated with Spondylolisthesis is BMP7 (Bone Morphogenetic Protein 7), and among its related pathways/superpathways are Degradation of the extracellular matrix and Spinal Cord Injury. The drugs Ketamine and Teriparatide have been mentioned in the context of this disorder. Affiliated tissues include set of vertebrae, bone and testes, and related phenotypes are spondylolysis and spondylolisthesis at l5-s1

Disease Ontology : ¹² A bone structure disease that has material basis in displacement located in set of vertebrae.

Wikipedia : ⁷⁴ Spondylolisthesis is the displacement of one spinal vertebra compared to another. While some medical... more...

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Related Diseases for Spondylolisthesis

Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)

#	Related Disease	Score	Top Affiliating Genes
1	spinal stenosis	30.8	RPL34 MMP3 LSS COL9A3 BMP7 ACAN
2	radiculopathy	30.2	RPL34 KLK8 HECTD4 BMP2 ACAN
3	osteonecrosis	30.2	ESR1 BMP7 BMP2
4	degenerative disc disease	30.2	RPL34 MMP3 GDF5 COL9A3 BMP2 ACAN
5	spondylolysis	30.1	TTR RPL34 LSS HECTD4 GDF5 FTH1
6	arachnoiditis	29.9	RPL34 CRP
7	arthropathy	29.8	PTGS2 MMP3 CRP ACAN
8	baastrup's syndrome	29.8	RPL34 CRP
9	discitis	29.8	RPL34 FTH1 CRP ACAN
10	exostosis	29.8	HECTD4 GDF5 BMP2 ACAN
11	cauda equina syndrome	29.7	TSKU RPL34 HECTD4 CRP
12	spondylosis	29.7	RPL34 RPL24 KLK8 HECTD4 ESR1 BMP2
13	osteoarthritis	29.6	PTGS2 MMP3 GDF5 CRP BMP2 ACAN
14	osteochondrosis	29.6	HECTD4 COL9A3 ACAN
15	pain agnosia	29.5	RPL34 PTGS2 HECTD4
16	synovitis	29.5	MMP3 CRP ACAN
17	osteochondritis dissecans	29.3	MMP3 COL9A3 BMP7 BMP2 ACAN
18	bone resorption disease	28.5	RPL24 HECTD4 ESR1 CRP BMP2
19	jaffer beighton syndrome	11.6
20	back pain	11.0
21	scoliosis	10.8
22	neural tube defects	10.5
23	intermittent claudication	10.5
24	pik3ca-related overgrowth syndrome	10.5
25	idiopathic scoliosis	10.4
26	spina bifida occulta	10.4
27	brachydactyly, type a1, b	10.4	GDF5 BMP2
28	spinal disease	10.4
29	femoral neuropathy	10.4	RPL34 RPL24
30	hydrarthrosis	10.4	MMP3 ACAN
31	polykaryocytosis inducer	10.3
32	proximal symphalangism	10.3	GDF5 BMP7 BMP2
33	brachydactyly, type a2	10.3	GDF5 BMP7 BMP2
34	paresthesia	10.3
35	cerebral palsy	10.3
36	spinal cord injury	10.3
37	chromosome 2q35 duplication syndrome	10.2	GDF5 BMP7 BMP2
38	cardiomyopathy, familial hypertrophic, 9	10.2	FTH1 ESR1
39	inflammatory spondylopathy	10.2
40	spondylitis	10.2
41	osteoporosis	10.2
42	brittle bone disorder	10.2
43	bone mineral density quantitative trait locus 8	10.2
44	bone mineral density quantitative trait locus 15	10.2
45	neurofibromatosis	10.2
46	foot drop	10.2
47	median neuropathy	10.1	TTR RPL24
48	scoliosis, isolated 1	10.1
49	spondylosis, cervical	10.1
50	ptosis	10.1

Graphical network of the top 20 diseases related to Spondylolisthesis:

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Symptoms & Phenotypes for Spondylolisthesis

Human phenotypes related to Spondylolisthesis:

³¹

#	Description	HPO Frequency	HPO Source Accession
1	spondylolysis ³¹		HP:0003304
2	spondylolisthesis at l5-s1 ³¹		HP:0008489

Symptoms via clinical synopsis from OMIM:

⁵⁶

Spine:
spondylolysis
spondylolisthesis of l5 on s1
defects in posterior spinous processes of l5 and sacrum

Clinical features from OMIM:

184200

UMLS symptoms related to Spondylolisthesis:

back pain

GenomeRNAi Phenotypes related to Spondylolisthesis according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	9.81	MMP3
2	Decreased viability	GR00055-A-2	9.81	MMP3
3	Decreased viability	GR00106-A-0	9.81	RPL34
4	Decreased viability	GR00221-A-1	9.81	ESR1
5	Decreased viability	GR00221-A-2	9.81	ESR1
6	Decreased viability	GR00221-A-4	9.81	ESR1
7	Decreased viability	GR00249-S	9.81	FTH1 HECTD4 LSS MMP3 RPL24 RPL34
8	Decreased viability	GR00381-A-1	9.81	COL9A3 LSS RPL24 RPL34
9	Decreased viability	GR00381-A-2	9.81	COL9A3
10	Decreased viability	GR00381-A-3	9.81	COL9A3
11	Decreased viability	GR00386-A-1	9.81	ESR1 GDF5 LSS RPL24 RPL34 TTR
12	Decreased viability	GR00402-S-2	9.81	BMP2 BMP7 COL9A3 ESR1 RPL24 RPL34

MGI Mouse Phenotypes related to Spondylolisthesis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.36	BMP2 BMP7 COL9A3 CRP ESR1 FTH1

Sources

Drugs & Therapeutics for Spondylolisthesis

Drugs for Spondylolisthesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Teriparatide

Approved, Investigational

Phase 4

52232-67-4

16133850

Parathyroid hormone

Approved, Investigational

Phase 4

9002-64-6

Pregabalin

Approved, Investigational

Phase 4

148553-50-8

5486971

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Neurotransmitter Agents

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Anesthetics, General

Phase 4

Anesthetics, Dissociative

Phase 4

Anesthetics, Intravenous

Phase 4

Calcium, Dietary

Phase 4

Hormones

Phase 4

Anti-Anxiety Agents

Phase 4

Psychotropic Drugs

Phase 4

Anticonvulsants

Phase 4

calcium channel blockers

Phase 4

Pharmaceutical Solutions

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Dexmedetomidine

Approved, Vet_approved

Phase 2, Phase 3

113775-47-6

5311068 68602

Epinephrine

Approved, Vet_approved

Phase 3

51-43-4

5816

Morphine

Approved, Investigational

Phase 3

57-27-2

5288826

Racepinephrine

Approved

Phase 3

329-65-7

838

Ropivacaine

Approved

Phase 3

84057-95-4

71273 175805

Teicoplanin

Approved, Investigational

Phase 3

61036-62-2

Lidocaine

Approved, Vet_approved

Phase 3

137-58-6

3676

Methylprednisolone

Approved, Vet_approved

Phase 3

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 3

2921-57-5

Prednisolone phosphate

Approved, Vet_approved

Phase 3

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 3

52-21-1

Prednisolone

Approved, Vet_approved

Phase 3

50-24-8

5755

Prednisolone hemisuccinate

Experimental

Phase 3

2920-86-7

Cortisone

Experimental

Phase 3

53-06-5

222786

Analgesics

Phase 2, Phase 3

Analgesics, Non-Narcotic

Phase 2, Phase 3

Hypnotics and Sedatives

Phase 2, Phase 3

Epinephryl borate

Phase 3

Adrenergic beta-Agonists

Phase 3

Adrenergic alpha-Agonists

Phase 3

Adrenergic Agents

Phase 3

Vasoconstrictor Agents

Phase 3

Anti-Asthmatic Agents

Phase 3

Adrenergic Agonists

Phase 3

Sympathomimetics

Phase 3

Mydriatics

Phase 3

Bronchodilator Agents

Phase 3

Anti-Bacterial Agents

Phase 3

Anti-Infective Agents

Phase 3

Antibiotics, Antitubercular

Phase 3

Anesthetics

Phase 3

Anesthetics, Local

Phase 3

Interventional clinical trials:

(show top 50) (show all 215)

#	Name	Status	NCT ID	Phase	Drugs
1	Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents	Completed	NCT01325493	Phase 4	Ketamine;Normal Saline
2	Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Degenerative Spondylolisthesis (DS) With Spinal Stenosis (SpS) at L4/L5 Level.	Completed	NCT00000409	Phase 4
3	A Prospective, Multi-Center, Post-Market Surveillance Study to Assess the Clinical Efficacy and Fusion Rates of the Zimmer TM Ardis Interbody Fusion System	Completed	NCT02429908	Phase 4
4	Spine Patient Outcomes Research Trial (SPORT): A Multicenter Trial for Spinal Stenosis (SpS)	Completed	NCT00000411	Phase 4
5	Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Intervertebral Disc Herniation (IDH)	Completed	NCT00000410	Phase 4
6	A Consecutive Case Series of One-Level Lumbar Fusions With Pedicle Screw Instrumentation and the Trabecular Metal™ Intervertebral Cage Using Roentgen Stereophotogrammetric Analysis (RSA)	Completed	NCT00493558	Phase 4
7	Assessment of the Efficacy of Forteo (Teriparatide) in Patients Undergoing Posterolateral Lumbar Spinal Fusion	Completed	NCT01292252	Phase 4
8	Interbody Fusion and Decompression Versus Instrumented Posterolateral Fusion and Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis	Recruiting	NCT01921530	Phase 4
9	Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation	Recruiting	NCT03745040	Phase 4	Liposomal bupivacaine
10	Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study	Recruiting	NCT03514277	Phase 4	Exparel;Bupivacaine
11	Effect of Pregabalin on Immediate Post-operative and Longterm Pain and Spinal Cord Monitoring in Children Undergoing Instrumented Spinal Surgery.	Recruiting	NCT02464813	Phase 4	Pregabalin;Sugar pill;Oxycodone
12	A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix	Recruiting	NCT04007094	Phase 4	ViviGen Cellular Bone Matrix
13	A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg	Active, not recruiting	NCT01934868	Phase 4	prolotherapy solution of 20% dextrose;Epidural Steroid Injection
14	Clinical and Radiographic Outcomes of BIO4 Bone Matrix in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery	Active, not recruiting	NCT03077204	Phase 4
15	Application of Platelet-Rich-Plasma in Posterolateral Lumbar Fusion	Not yet recruiting	NCT03779945	Phase 4
16	Lumbar Interbody Fusion Using The Telamon® Peek™ Versus The Telamon® Hydrosorb™ Fusion Device - A Prospective, Randomized Controlled Trial To Assess Surgical And Clinical Outcomes	Terminated	NCT00095095	Phase 4
17	Efficacy Study Using Solum IV, Bone Marrow Concentrate With General Fluid Concentrate in Transforaminal Lumbar Interbody Fusion	Withdrawn	NCT03223701	Phase 4
18	A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis	Unknown status	NCT00418197	Phase 3
19	The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation	Unknown status	NCT01618435	Phase 3
20	Immune Effect of Dexmedetomidine as Immunomodulatory Anesthesic Agent in Patients Undergoing to Spinal Fusion: a Double-blind, Randomized and Placebo-controlled Clinical Trial	Unknown status	NCT02854904	Phase 2, Phase 3	Dexmedetomidine intervention;Placebo
21	Neurosurgery Patient Outcomes in Treating Spinal Disorders	Completed	NCT01220921	Phase 3
22	Greenwich Lumbar Stenosis SLIP Study: A Multi-center, Randomized, Prospective Clinical Trial Comparing Spinal Laminectomy to Laminectomy With Instrumented Pedicle Screw Fusion for Lumbar Stenosis With Grade I Spondylolisthesis	Completed	NCT00109213	Phase 3
23	A Prospective, Multi-Center Clinical Study to Assess the Saftey and Effectiveness of the Impliant TOPS System	Completed	NCT00405691	Phase 3
24	Efficacy of Peri-Incisional Multimodal Drug Injection in Reducing Post-Operative Pain Following Lumbar Spine Surgery	Recruiting	NCT03513445	Phase 3	Morphine;Epinephrine;naropin
25	A Post-market, Prospective, Multi-center, Nonrandomized Study to Assess Posterolateral Lumbar Fusions Using FIBERGRAFT BG Matrix	Enrolling by invitation	NCT03884283	Phase 3
26	Does Teicoplanin Powder Use In Lumbar Instrumentation Surgery Reduce Surgical Site Infection	Not yet recruiting	NCT04341831	Phase 3	Teicoplanin
27	A Clinical Study of the Dynesys(R) Spinal System As a Non-fusion Device for Spinal Stabilization	Terminated	NCT00759057	Phase 3
28	A Multicenter, Randomized, Blinded, Saline-Controlled Trial of Resorbable Biologic Disc Augmentation for Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System	Terminated	NCT01011816	Phase 3	Saline
29	A Prospective, Multi-center, Pivotal Trial for INFUSE® Bone Graft With CAPSTONE® Spinal System and Posterior Supplemental Fixation to Treat 1- or 2-level Advanced Degenerative Disease of the Lumbosacral Spine For a TLIF Approach	Terminated	NCT01415908	Phase 3
30	Randomized, Prospective Study of Lumbar Transforaminal Epidural Corticosteroid Injection(s) Versus Defined Physical Therapy for the Treatment of Subacute Lumbar Radicular Pain Due to Disc Protrusion	Terminated	NCT01443819	Phase 3
31	A Multi-Center, Prospective, Parallel Group, Randomized, Pilot Study Evaluating Safety and Preliminary Effectiveness Of Prefix Compared To Iliac Crest Bone In Subjects With DDD Undergoing Transforaminal Lumbar Interbody Fusion	Unknown status	NCT00798902	Phase 1, Phase 2
32	A Multi-Center, Prospective, Parallel Group, Randomized, Pilot Study Evaluating Safety and Preliminary Effectiveness Of Prefix Compared To Iliac Crest Bone In Subjects With DDD Undergoing Transforaminal Lumbar Interbody Fusion	Unknown status	NCT00798239	Phase 1, Phase 2
33	Multicentric, Prospective Study of Efficacy and Safety of Lumbar Interbody Fusion With MatriTMBONE Associated With Autologous Marrow	Unknown status	NCT01335243	Phase 2
34	"Ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue for Spinal Fusion in Spine Degenerative Disease	Completed	NCT01552707	Phase 1, Phase 2
35	Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation	Completed	NCT01106417	Phase 2
36	Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation	Completed	NCT01097486	Phase 2
37	Transverse Abdominis Plane Block for Anterior Approach Spine Surgery: A Prospective Randomized Study	Completed	NCT02884440	Phase 2	TAP block ropivacaine;TAP block placebo;General anesthesia
38	A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Lumbar Interbody Fusion With Instrumentation	Completed	NCT00996073	Phase 2
39	A Dose-escalation Study to Assess the Feasibility and Safety of 3 Different Doses of NeoFuse When Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion With Instrumentation.	Completed	NCT00549913	Phase 1, Phase 2
40	A Pilot Trial of Intravenous Pamidronate for Low Back Pain	Completed	NCT01210599	Phase 1, Phase 2	Pamidronate
41	Multicentered, Randomized Study of Safety and Efficacy of Whole-body Vibration as add-on to Standard Pharmacological Treatment of Osteoporosis in Post-menopausal Women	Completed	NCT01415050	Phase 2
42	A Prospective Multi-centre, Randomised, Controlled Study to Evaluate the Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis by Interbody Fusion (L1 - S1)	Active, not recruiting	NCT03100032	Phase 1, Phase 2
43	A Pilot Phase 2a, Multicentre, Open, Proof-of-concept Study on the Safety and the Efficacy of Allogeneic Osteoblastic Cells (ALLOB®) Implantation in Lumbar Spinal Fusion	Active, not recruiting	NCT02205138	Phase 2	ALLOB® cells with ceramic scaffold
44	A Phase 1b/2a Safety Evaluation of ART352-L in Patients Undergoing Posterolateral Spinal Fusion	Not yet recruiting	NCT04378543	Phase 1, Phase 2
45	A Prospective Study Assessing Clinical Outcomes and Radiographic Results After the Use of CopiOs(R) Bone Void Filler (BVF)Sponge in a Posterolateral Fusion Procedure (PLF).	Terminated	NCT01123850	Phase 2
46	A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With Mastergraft Granules in Subjects Undergoing Posterolateral Lumbar Fusion With Instrumentation	Withdrawn	NCT00810212	Phase 1, Phase 2
47	Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions: A Randomized, Double-blinded, Controlled Trial	Not yet recruiting	NCT04112550	Phase 1	Methadone Hydrochloride;Oxycodone-Acetaminophen
48	A Study to Evaluate the Safety and Effectiveness of the TOPS System	Unknown status	NCT02234154
49	A Study to Evaluate the Safety and Effectiveness of the TOPS System	Unknown status	NCT01933607
50	Prospective Study of Minimally Invasive Spinal Fusion Surgery for the Treatment of Spondylolisthesis, Degenerative Disk Disease, Spinal Stenosis and Degenerative Scoliosis	Unknown status	NCT01045473

Search NIH Clinical Center for Spondylolisthesis

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Spondylolisthesis cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Spondylolisthesis:

MPCs, mesenchymal precursor cells for bone fusion

Embryonic/Adult Cultured Cells Related to Spondylolisthesis:

Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spondylolisthesis

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Genetic Tests for Spondylolisthesis

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Anatomical Context for Spondylolisthesis

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolisthesis:

¹⁹

Set Of Vertebrae

MalaCards organs/tissues related to Spondylolisthesis:

⁴⁰

Bone, Testes, Bone Marrow, Spinal Cord, Kidney, Colon, Brain

Sources

Publications for Spondylolisthesis

Articles related to Spondylolisthesis:

(show top 50) (show all 5036)

#	Title	Authors	PMID	Year
1	Familial spondylolisthesis of the axis vertebra. ⁶¹ ⁵⁶	Nordstrom RE...Laasonen EM	3536939	1986
2	Family study of spondylolysis and spondylolisthesis. ⁵⁶ ⁶¹	Albanese M...Pizzutillo PD	6761366	1982
3	A family with spondylolisthesis. ⁵⁶ ⁶¹	Shahriaree H...Rooholamini SA	511891	1979
4	Familial occurrence of lumbar spondylolysis and spondylolisthesis. ⁶¹ ⁵⁶	Haukipuro K...Punto L	668183	1978
5	Fatigue fracture: the basic lesion is inthmic spondylolisthesis. ⁶¹ ⁵⁶	Wiltse LL...Jackson DW	1123367	1975
6	A family with spondylolisthesis. ⁵⁶ ⁶¹	Shahriaree H...Harkess JW	5413907	1970
7	Hereditary spondylolisthesis and spina bifida. Report of a family in which the lesion is transmitted as an autosomal dominant through three generations. ⁵⁶ ⁶¹	Amuso SJ...Mankin HJ	5336847	1967
8	The etiology of spondylolisthesis. ⁵⁶ ⁶¹	WILTSE LL	14040287	1962
9	Examination of the possibility that certain skeletal characters predispose to defects in the lumbar neural arches. ⁵⁶	STEWART TD	13374901	1956
10	[The age incidence of neural-arch defects in Alaskan natives, considered from the standpoint of etiology]. ⁵⁶	STEWART TD	13108895	1953
11	A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. ⁵⁴ ⁶¹	Vaccaro AR...Albert TJ	15672240	2005
12	A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. ⁶¹ ⁵⁴	Vaccaro AR...McCulloch JA	15534410	2004
13	A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. ⁵⁴ ⁶¹	Vaccaro AR...Albert TJ	12908103	2003
14	Cortical bone trajectory instrumentation provides favorable perioperative outcomes compared to pedicle screws for single-level lumbar spinal stenosis and degenerative spondylolisthesis. ⁶¹	Menon N...Patton CM	32382216	2020
15	Magnetic resonance imaging findings of the lumbar spine, back symptoms and physical function among male adult patients with Scheuermann's disease. ⁶¹	Ristolainen L...Schlenzka D	32139999	2020
16	Lumbar intervertebral disc mRNA sequencing identifies the regulatory pathway in patients with disc herniation and spondylolisthesis. ⁶¹	Bydon M...van Wijnen AJ	32240779	2020
17	Percutaneous transforaminal endoscopic decompression for lumbar spinal stenosis with degenerative spondylolisthesis in the elderly. ⁶¹	Cheng XK...Chen B	32446122	2020
18	Etiology-Based Classification of Adjacent Segment Disease Following Lumbar Spine Fusion. ⁶¹	Louie PK...An HS	32523480	2020
19	Minimally Invasive Spine Lumbar Surgery in Obese Patients: A Systematic Review and Meta-Analysis. ⁶¹	Othman YA...Qureshi SA	32523485	2020
20	Predictors of the Best Outcomes Following Minimally Invasive Surgery for Grade 1 Degenerative Lumbar Spondylolisthesis. ⁶¹	Chan AK...Mummaneni PV	32497184	2020
21	Epidural Steroid Injections for Management of Degenerative Spondylolisthesis: Little Effect on Clinical Outcomes in Operatively and Nonoperatively Treated Patients. ⁶¹	Gerling MC...Passias PG	32555000	2020
22	Results of Decompression Alone in Patients with Lumbar Spinal Stenosis and Degenerative Spondylolisthesis: A Minimum 5-Year Follow-up. ⁶¹	Ha DH...Shim DM	32489540	2020
23	Evaluation of lumbar fusion using the anterior to psoas approach for the treatment of L5/S1 spondylolisthesis. ⁶¹	He W...Tian W	32501966	2020
24	Systematic Review of Outcomes Following 10-Year Mark of Spine Patient Outcomes Research Trial (SPORT) for Degenerative Spondylolisthesis. ⁶¹	Oster BA...Cho W	32205705	2020
25	Comparison of Minimal Invasive Versus Biportal Endoscopic Transforaminal Lumbar Interbody Fusion for Single-level Lumbar Disease. ⁶¹	Kim JE...Jee SM	32496311	2020
26	Clinical Significance of Radiologic Improvement Following Single-Level Oblique Lateral Interbody Fusion With Percutaneous Pedicle Screw Fixation. ⁶¹	Chang SY...Kim H	32501518	2020
27	Indirect Decompression Using Lateral Lumbar Interbody Fusion for Restenosis after an Initial Decompression Surgery. ⁶¹	Nakashima H...Imagama S	31906613	2020
28	Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway. ⁶¹	Lu Y...Hu ZM	32151764	2020
29	Comparison of the Prevalence of Low Back Pain and Related Spinal Diseases among Smokers and Nonsmokers: Using Korean National Health Insurance Database. ⁶¹	Kwon JW...Park Y	32489542	2020
30	Full Percutaneous Treatment of Degenerative Disc Disease with Intradiscal Lumbar Interbody Fusion and Posterior Stabilization: Preliminary Results. ⁶¹	Fiori R...Floris R	32342158	2020
31	Trends in Anterior Lumbar Interbody Fusion in the United States: A MarketScan Study From 2007 to 2014. ⁶¹	Varshneya K...Veeravagu A	31609798	2020
32	Effect of Surgical Setting on Hospital-Reported Outcomes for Elective Lumbar Spinal Procedures: Tertiary Versus Community Hospitals. ⁶¹	Weir TB...Ludwig SC	32435555	2020
33	Complication profile associated with S1 pedicle subtraction osteotomy compared with 3-column osteotomies at other thoracolumbar levels for adult spinal deformity: series of 405 patients with 9 S1 osteotomies. ⁶¹	Lau D...Ames CP	32559748	2020
34	[The Facet Wedge: a minimally invasive technique for posterior segmental intra-articular fusion]. ⁶¹	Mehren C...Korge A	32179944	2020
35	[Minimally invasive stand-alone fusion of the lumbosacral junction]. ⁶¹	Stosch-Wiechert K...Siepe CJ	32468147	2020
36	Fusion rate for stand-alone lateral lumbar interbody fusion: a systematic review. ⁶¹	Manzur MK...Qureshi SA	32535072	2020
37	Simultaneous single-position lateral interbody fusion and percutaneous pedicle screw fixation using O-arm-based navigation reduces the occupancy time of the operating room. ⁶¹	Ouchida J...Imagama S	32239355	2020
38	Predicting prolonged opioid prescriptions in opioid-naïve lumbar spine surgery patients. ⁶¹	Karhade AV...Schwab JH	31901553	2020
39	Lumbar spondylolisthesis associated with systemic sclerosis-related spinal calcinosis: an unusual clinical case. ⁶¹	Delvino P...Cavagna L	32556288	2020
40	Is Reduction and Fusion Required for High-grade Spondylolisthesis? ⁶¹	Pinter ZW...Sebastian AS	32554987	2020
41	Ipsilateral Pedicle Stress Fracture After Endoscopic Foraminal Decompression for Patient with Isthmic Spondylolisthesis. ⁶¹	Nam WD...Hong CG	32145413	2020
42	Reduction versus In Situ Fusion for Adult High-Grade Spondylolisthesis: A Systematic Review and Meta-Analysis. ⁶¹	Lak AM...Zaidi HA	32179186	2020
43	Grade V Thoracic Spondylolisthesis in Neurofibromatosis Type 1: Case Report and Literature Review. ⁶¹	Yuan W...Zhu Y	32201295	2020
44	Inter-observer Variance and Patient Heterogeneity Influencing The Treatment of Grade I Spondylolisthesis. ⁶¹	Resnick DK...Ghogawala Z	32534135	2020
45	Microendoscopic discectomy versus minimally invasive transforaminal lumbar interbody fusion for lumbar spinal stenosis without spondylolisthesis. ⁶¹	Yi W...Zhou Y	32541527	2020
46	Minimally invasive surgery for low-grade spondylolisthesis: percutaneous endoscopic or oblique lumbar interbody fusion. ⁶¹	Jin M...Huang Y	32551889	2020
47	Fusion in situ versus reduction for spondylolisthesis treatment: grading the evidence through a meta-analysis. ⁶¹	He R...Shang X	32510149	2020
48	Sagittally Balanced Degenerative Spondylolisthesis Patients With Increased Sacral Slope and Greater Lumbar Lordosis Experience Less Back Pain After Short-Segment Lumbar Fusion Surgery. ⁶¹	Liow MHL...Chen JL	31913174	2020
49	The Influence of Cervical Spondylolisthesis on Clinical Presentation and Surgical Outcome in Patients With DCM: Analysis of a Multicenter Global Cohort of 458 Patients. ⁶¹	Nouri A...Fehlings MG	32435566	2020
50	Comparison of Outcomes of Oblique Lateral Interbody Fusion with Percutaneous Posterior Fixation in Lateral Position and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Degenerative Spondylolisthesis. ⁶¹	Koike Y...Iwasaki N	32521951	2020

Sources

Genes for Spondylolisthesis

Genes related to Spondylolisthesis (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	BMP7	Bone Morphogenetic Protein 7	Protein Coding	13.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15672240 15534410 12908103
2	GDF5	Growth Differentiation Factor 5	Protein Coding	11.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MMP3	Matrix Metallopeptidase 3	Protein Coding	11.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	10.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	ESR1	Estrogen Receptor 1	Protein Coding	10.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	RPL34	Ribosomal Protein L34	Protein Coding	9.61	DISEASES inferred ¹⁵
7	FTH1	Ferritin Heavy Chain 1	Protein Coding	8.7	DISEASES inferred ¹⁵
8	BMP2	Bone Morphogenetic Protein 2	Protein Coding	7.4	DISEASES inferred ¹⁵
9	LSS	Lanosterol Synthase	Protein Coding	7.22	DISEASES inferred ¹⁵
10	KLK8	Kallikrein Related Peptidase 8	Protein Coding	6.5	DISEASES inferred ¹⁵
11	TSKU	Tsukushi, Small Leucine Rich Proteoglycan	Protein Coding	6.25	DISEASES inferred ¹⁵
12	RPL24	Ribosomal Protein L24	Protein Coding	6.13	DISEASES inferred ¹⁵
13	IDS	Iduronate 2-Sulfatase	Protein Coding	6.06	DISEASES inferred ¹⁵
14	ACAN	Aggrecan	Protein Coding	6.04	DISEASES inferred ¹⁵
15	ZNF799	Zinc Finger Protein 799	Protein Coding	5.97	DISEASES inferred ¹⁵
16	COL9A3	Collagen Type IX Alpha 3 Chain	Protein Coding	5.74	DISEASES inferred ¹⁵
17	TTR	Transthyretin	Protein Coding	5.69	DISEASES inferred ¹⁵
18	CRP	C-Reactive Protein	Protein Coding	5.61	DISEASES inferred ¹⁵
19	HECTD4	HECT Domain E3 Ubiquitin Protein Ligase 4	Protein Coding	5.6	DISEASES inferred ¹⁵
20	SMR3A	Submaxillary Gland Androgen Regulated Protein 3A	Protein Coding	5.6	DISEASES inferred ¹⁵

Sources

Variations for Spondylolisthesis

Sources

Expression for Spondylolisthesis

Search GEO for disease gene expression data for Spondylolisthesis.

Sources

Pathways for Spondylolisthesis

Pathways related to Spondylolisthesis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	11.82	TTR MMP3 GDF5 COL9A3 BMP7 BMP2
2	Spinal Cord Injury ¹	11.66	PTGS2 KLK8 ACAN
3	TGF-beta signaling pathway (KEGG) ³⁶	11.41	GDF5 BMP7 BMP2
4	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁴	11.23	GDF5 BMP7 BMP2 ACAN
5	Elastic fibre formation ⁶⁵ Show member pathways Molecules associated with elastic fibres ⁶⁵	11.2	GDF5 BMP7 BMP2
6	Overview of nanoparticle effects ¹	10.65	PTGS2 CRP
7	G-protein signaling_Rap2B regulation pathway ²²	10.62	GDF5 COL9A3 BMP7 BMP2 ACAN

Sources

GO Terms for Spondylolisthesis

Cellular components related to Spondylolisthesis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.61	TTR TSKU MMP3 KLK8 GDF5 CRP
2	extracellular region	GO:0005576	9.4	TTR TSKU SMR3A MMP3 KLK8 GDF5

Biological processes related to Spondylolisthesis according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix organization	GO:0030198	9.78	TTR MMP3 COL9A3 ACAN
2	response to estradiol	GO:0032355	9.71	PTGS2 ESR1 BMP7
3	positive regulation of neuron differentiation	GO:0045666	9.69	GDF5 BMP7 BMP2
4	BMP signaling pathway	GO:0030509	9.67	GDF5 BMP7 BMP2
5	cartilage development	GO:0051216	9.61	GDF5 BMP7 BMP2
6	response to vitamin D	GO:0033280	9.55	PTGS2 BMP7
7	positive regulation of brown fat cell differentiation	GO:0090336	9.52	PTGS2 BMP7
8	SMAD protein signal transduction	GO:0060395	9.5	GDF5 BMP7 BMP2
9	regulation of neuroinflammatory response	GO:0150077	9.46	PTGS2 MMP3
10	negative regulation of blood vessel diameter	GO:0097756	9.4	PTGS2 CRP
11	mesenchymal cell differentiation	GO:0048762	9.37	BMP7 BMP2
12	regulation of branching involved in prostate gland morphogenesis	GO:0060687	9.26	ESR1 BMP7
13	mesenchyme development	GO:0060485	9.16	BMP7 BMP2
14	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:0010862	9.13	GDF5 BMP7 BMP2
15	negative regulation of cell cycle	GO:0045786	8.8	PTGS2 BMP7 BMP2

Molecular functions related to Spondylolisthesis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	BMP receptor binding	GO:0070700	8.62	BMP7 BMP2

Sources

Sources for Spondylolisthesis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia