Aliases & Classifications for Spondylolisthesis

MalaCards integrated aliases for Spondylolisthesis:

Name: Spondylolisthesis 56 12 54 43 15 37 17 71 32



autosomal dominant


Inheritance autosomal dominant inheritance


External Ids:

Disease Ontology 12 DOID:6682
OMIM 56 184200
MeSH 43 D013168
NCIt 49 C35033
SNOMED-CT 67 274152003
ICD10 32 M43.1
MedGen 41 C0038016
SNOMED-CT via HPO 68 240221008 263681008
UMLS 71 C0038016

Summaries for Spondylolisthesis

OMIM : 56 Spondylolisthesis is defined as forward slipping of a vertebral body on the one below it. Spondylolysis is defined as a defect in the pars interarticularis without vertebral slipping (summary by Wiltse et al., 1975). (184200)

MalaCards based summary : Spondylolisthesis is related to spinal stenosis and radiculopathy, and has symptoms including back pain An important gene associated with Spondylolisthesis is BMP7 (Bone Morphogenetic Protein 7), and among its related pathways/superpathways are Degradation of the extracellular matrix and Spinal Cord Injury. The drugs Ketamine and Teriparatide have been mentioned in the context of this disorder. Affiliated tissues include set of vertebrae, bone and testes, and related phenotypes are spondylolysis and spondylolisthesis at l5-s1

Disease Ontology : 12 A bone structure disease that has material basis in displacement located in set of vertebrae.

Wikipedia : 74 Spondylolisthesis is the displacement of one spinal vertebra compared to another. While some medical... more...

Related Diseases for Spondylolisthesis

Diseases related to Spondylolisthesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 spinal stenosis 30.8 RPL34 MMP3 LSS COL9A3 BMP7 ACAN
2 radiculopathy 30.2 RPL34 KLK8 HECTD4 BMP2 ACAN
3 osteonecrosis 30.2 ESR1 BMP7 BMP2
4 degenerative disc disease 30.2 RPL34 MMP3 GDF5 COL9A3 BMP2 ACAN
5 spondylolysis 30.1 TTR RPL34 LSS HECTD4 GDF5 FTH1
6 arachnoiditis 29.9 RPL34 CRP
7 arthropathy 29.8 PTGS2 MMP3 CRP ACAN
8 baastrup's syndrome 29.8 RPL34 CRP
9 discitis 29.8 RPL34 FTH1 CRP ACAN
10 exostosis 29.8 HECTD4 GDF5 BMP2 ACAN
11 cauda equina syndrome 29.7 TSKU RPL34 HECTD4 CRP
12 spondylosis 29.7 RPL34 RPL24 KLK8 HECTD4 ESR1 BMP2
13 osteoarthritis 29.6 PTGS2 MMP3 GDF5 CRP BMP2 ACAN
14 osteochondrosis 29.6 HECTD4 COL9A3 ACAN
15 pain agnosia 29.5 RPL34 PTGS2 HECTD4
16 synovitis 29.5 MMP3 CRP ACAN
17 osteochondritis dissecans 29.3 MMP3 COL9A3 BMP7 BMP2 ACAN
18 bone resorption disease 28.5 RPL24 HECTD4 ESR1 CRP BMP2
19 jaffer beighton syndrome 11.6
20 back pain 11.0
21 scoliosis 10.8
22 neural tube defects 10.5
23 intermittent claudication 10.5
24 pik3ca-related overgrowth syndrome 10.5
25 idiopathic scoliosis 10.4
26 spina bifida occulta 10.4
27 brachydactyly, type a1, b 10.4 GDF5 BMP2
28 spinal disease 10.4
29 femoral neuropathy 10.4 RPL34 RPL24
30 hydrarthrosis 10.4 MMP3 ACAN
31 polykaryocytosis inducer 10.3
32 proximal symphalangism 10.3 GDF5 BMP7 BMP2
33 brachydactyly, type a2 10.3 GDF5 BMP7 BMP2
34 paresthesia 10.3
35 cerebral palsy 10.3
36 spinal cord injury 10.3
37 chromosome 2q35 duplication syndrome 10.2 GDF5 BMP7 BMP2
38 cardiomyopathy, familial hypertrophic, 9 10.2 FTH1 ESR1
39 inflammatory spondylopathy 10.2
40 spondylitis 10.2
41 osteoporosis 10.2
42 brittle bone disorder 10.2
43 bone mineral density quantitative trait locus 8 10.2
44 bone mineral density quantitative trait locus 15 10.2
45 neurofibromatosis 10.2
46 foot drop 10.2
47 median neuropathy 10.1 TTR RPL24
48 scoliosis, isolated 1 10.1
49 spondylosis, cervical 10.1
50 ptosis 10.1

Graphical network of the top 20 diseases related to Spondylolisthesis:

Diseases related to Spondylolisthesis

Symptoms & Phenotypes for Spondylolisthesis

Human phenotypes related to Spondylolisthesis:

# Description HPO Frequency HPO Source Accession
1 spondylolysis 31 HP:0003304
2 spondylolisthesis at l5-s1 31 HP:0008489

Symptoms via clinical synopsis from OMIM:

spondylolisthesis of l5 on s1
defects in posterior spinous processes of l5 and sacrum

Clinical features from OMIM:


UMLS symptoms related to Spondylolisthesis:

back pain

GenomeRNAi Phenotypes related to Spondylolisthesis according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.81 MMP3
2 Decreased viability GR00055-A-2 9.81 MMP3
3 Decreased viability GR00106-A-0 9.81 RPL34
4 Decreased viability GR00221-A-1 9.81 ESR1
5 Decreased viability GR00221-A-2 9.81 ESR1
6 Decreased viability GR00221-A-4 9.81 ESR1
7 Decreased viability GR00249-S 9.81 FTH1 HECTD4 LSS MMP3 RPL24 RPL34
8 Decreased viability GR00381-A-1 9.81 COL9A3 LSS RPL24 RPL34
9 Decreased viability GR00381-A-2 9.81 COL9A3
10 Decreased viability GR00381-A-3 9.81 COL9A3
11 Decreased viability GR00386-A-1 9.81 ESR1 GDF5 LSS RPL24 RPL34 TTR
12 Decreased viability GR00402-S-2 9.81 BMP2 BMP7 COL9A3 ESR1 RPL24 RPL34

MGI Mouse Phenotypes related to Spondylolisthesis:

# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 BMP2 BMP7 COL9A3 CRP ESR1 FTH1

Drugs & Therapeutics for Spondylolisthesis

Drugs for Spondylolisthesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
6 Neurotransmitter Agents Phase 4
7 Excitatory Amino Acid Antagonists Phase 4
8 Anesthetics, General Phase 4
9 Anesthetics, Dissociative Phase 4
10 Anesthetics, Intravenous Phase 4
11 Calcium, Dietary Phase 4
12 Hormones Phase 4
13 Anti-Anxiety Agents Phase 4
14 Psychotropic Drugs Phase 4
15 Anticonvulsants Phase 4
16 calcium channel blockers Phase 4
17 Pharmaceutical Solutions Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 113775-47-6 5311068 68602
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
Morphine Approved, Investigational Phase 3 57-27-2 5288826
Racepinephrine Approved Phase 3 329-65-7 838
Ropivacaine Approved Phase 3 84057-95-4 71273 175805
Teicoplanin Approved, Investigational Phase 3 61036-62-2
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
29 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
Cortisone Experimental Phase 3 53-06-5 222786
33 Analgesics Phase 2, Phase 3
34 Analgesics, Non-Narcotic Phase 2, Phase 3
35 Hypnotics and Sedatives Phase 2, Phase 3
36 Epinephryl borate Phase 3
37 Adrenergic beta-Agonists Phase 3
38 Adrenergic alpha-Agonists Phase 3
39 Adrenergic Agents Phase 3
40 Vasoconstrictor Agents Phase 3
41 Anti-Asthmatic Agents Phase 3
42 Adrenergic Agonists Phase 3
43 Sympathomimetics Phase 3
44 Mydriatics Phase 3
45 Bronchodilator Agents Phase 3
46 Anti-Bacterial Agents Phase 3
47 Anti-Infective Agents Phase 3
48 Antibiotics, Antitubercular Phase 3
49 Anesthetics Phase 3
50 Anesthetics, Local Phase 3

Interventional clinical trials:

(show top 50) (show all 215)
# Name Status NCT ID Phase Drugs
1 Modulation of μ Opioid Receptor Mediated Analgesia, Tolerance and Hyperalgesia in Children and Adolescents Completed NCT01325493 Phase 4 Ketamine;Normal Saline
2 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Degenerative Spondylolisthesis (DS) With Spinal Stenosis (SpS) at L4/L5 Level. Completed NCT00000409 Phase 4
3 A Prospective, Multi-Center, Post-Market Surveillance Study to Assess the Clinical Efficacy and Fusion Rates of the Zimmer TM Ardis Interbody Fusion System Completed NCT02429908 Phase 4
4 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Trial for Spinal Stenosis (SpS) Completed NCT00000411 Phase 4
5 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Intervertebral Disc Herniation (IDH) Completed NCT00000410 Phase 4
6 A Consecutive Case Series of One-Level Lumbar Fusions With Pedicle Screw Instrumentation and the Trabecular Metal™ Intervertebral Cage Using Roentgen Stereophotogrammetric Analysis (RSA) Completed NCT00493558 Phase 4
7 Assessment of the Efficacy of Forteo (Teriparatide) in Patients Undergoing Posterolateral Lumbar Spinal Fusion Completed NCT01292252 Phase 4
8 Interbody Fusion and Decompression Versus Instrumented Posterolateral Fusion and Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
9 Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation Recruiting NCT03745040 Phase 4 Liposomal bupivacaine
10 Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
11 Effect of Pregabalin on Immediate Post-operative and Longterm Pain and Spinal Cord Monitoring in Children Undergoing Instrumented Spinal Surgery. Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
12 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
13 A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg Active, not recruiting NCT01934868 Phase 4 prolotherapy solution of 20% dextrose;Epidural Steroid Injection
14 Clinical and Radiographic Outcomes of BIO4 Bone Matrix in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery Active, not recruiting NCT03077204 Phase 4
15 Application of Platelet-Rich-Plasma in Posterolateral Lumbar Fusion Not yet recruiting NCT03779945 Phase 4
16 Lumbar Interbody Fusion Using The Telamon® Peek™ Versus The Telamon® Hydrosorb™ Fusion Device - A Prospective, Randomized Controlled Trial To Assess Surgical And Clinical Outcomes Terminated NCT00095095 Phase 4
17 Efficacy Study Using Solum IV, Bone Marrow Concentrate With General Fluid Concentrate in Transforaminal Lumbar Interbody Fusion Withdrawn NCT03223701 Phase 4
18 A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis Unknown status NCT00418197 Phase 3
19 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation Unknown status NCT01618435 Phase 3
20 Immune Effect of Dexmedetomidine as Immunomodulatory Anesthesic Agent in Patients Undergoing to Spinal Fusion: a Double-blind, Randomized and Placebo-controlled Clinical Trial Unknown status NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo
21 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
22 Greenwich Lumbar Stenosis SLIP Study: A Multi-center, Randomized, Prospective Clinical Trial Comparing Spinal Laminectomy to Laminectomy With Instrumented Pedicle Screw Fusion for Lumbar Stenosis With Grade I Spondylolisthesis Completed NCT00109213 Phase 3
23 A Prospective, Multi-Center Clinical Study to Assess the Saftey and Effectiveness of the Impliant TOPS System Completed NCT00405691 Phase 3
24 Efficacy of Peri-Incisional Multimodal Drug Injection in Reducing Post-Operative Pain Following Lumbar Spine Surgery Recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
25 A Post-market, Prospective, Multi-center, Nonrandomized Study to Assess Posterolateral Lumbar Fusions Using FIBERGRAFT BG Matrix Enrolling by invitation NCT03884283 Phase 3
26 Does Teicoplanin Powder Use In Lumbar Instrumentation Surgery Reduce Surgical Site Infection Not yet recruiting NCT04341831 Phase 3 Teicoplanin
27 A Clinical Study of the Dynesys(R) Spinal System As a Non-fusion Device for Spinal Stabilization Terminated NCT00759057 Phase 3
28 A Multicenter, Randomized, Blinded, Saline-Controlled Trial of Resorbable Biologic Disc Augmentation for Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
29 A Prospective, Multi-center, Pivotal Trial for INFUSE® Bone Graft With CAPSTONE® Spinal System and Posterior Supplemental Fixation to Treat 1- or 2-level Advanced Degenerative Disease of the Lumbosacral Spine For a TLIF Approach Terminated NCT01415908 Phase 3
30 Randomized, Prospective Study of Lumbar Transforaminal Epidural Corticosteroid Injection(s) Versus Defined Physical Therapy for the Treatment of Subacute Lumbar Radicular Pain Due to Disc Protrusion Terminated NCT01443819 Phase 3
31 A Multi-Center, Prospective, Parallel Group, Randomized, Pilot Study Evaluating Safety and Preliminary Effectiveness Of Prefix Compared To Iliac Crest Bone In Subjects With DDD Undergoing Transforaminal Lumbar Interbody Fusion Unknown status NCT00798902 Phase 1, Phase 2
32 A Multi-Center, Prospective, Parallel Group, Randomized, Pilot Study Evaluating Safety and Preliminary Effectiveness Of Prefix Compared To Iliac Crest Bone In Subjects With DDD Undergoing Transforaminal Lumbar Interbody Fusion Unknown status NCT00798239 Phase 1, Phase 2
33 Multicentric, Prospective Study of Efficacy and Safety of Lumbar Interbody Fusion With MatriTMBONE Associated With Autologous Marrow Unknown status NCT01335243 Phase 2
34 "Ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue for Spinal Fusion in Spine Degenerative Disease Completed NCT01552707 Phase 1, Phase 2
35 Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation Completed NCT01106417 Phase 2
36 Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation Completed NCT01097486 Phase 2
37 Transverse Abdominis Plane Block for Anterior Approach Spine Surgery: A Prospective Randomized Study Completed NCT02884440 Phase 2 TAP block ropivacaine;TAP block placebo;General anesthesia
38 A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Lumbar Interbody Fusion With Instrumentation Completed NCT00996073 Phase 2
39 A Dose-escalation Study to Assess the Feasibility and Safety of 3 Different Doses of NeoFuse When Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion With Instrumentation. Completed NCT00549913 Phase 1, Phase 2
40 A Pilot Trial of Intravenous Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
41 Multicentered, Randomized Study of Safety and Efficacy of Whole-body Vibration as add-on to Standard Pharmacological Treatment of Osteoporosis in Post-menopausal Women Completed NCT01415050 Phase 2
42 A Prospective Multi-centre, Randomised, Controlled Study to Evaluate the Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis by Interbody Fusion (L1 - S1) Active, not recruiting NCT03100032 Phase 1, Phase 2
43 A Pilot Phase 2a, Multicentre, Open, Proof-of-concept Study on the Safety and the Efficacy of Allogeneic Osteoblastic Cells (ALLOB®) Implantation in Lumbar Spinal Fusion Active, not recruiting NCT02205138 Phase 2 ALLOB® cells with ceramic scaffold
44 A Phase 1b/2a Safety Evaluation of ART352-L in Patients Undergoing Posterolateral Spinal Fusion Not yet recruiting NCT04378543 Phase 1, Phase 2
45 A Prospective Study Assessing Clinical Outcomes and Radiographic Results After the Use of CopiOs(R) Bone Void Filler (BVF)Sponge in a Posterolateral Fusion Procedure (PLF). Terminated NCT01123850 Phase 2
46 A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With Mastergraft Granules in Subjects Undergoing Posterolateral Lumbar Fusion With Instrumentation Withdrawn NCT00810212 Phase 1, Phase 2
47 Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions: A Randomized, Double-blinded, Controlled Trial Not yet recruiting NCT04112550 Phase 1 Methadone Hydrochloride;Oxycodone-Acetaminophen
48 A Study to Evaluate the Safety and Effectiveness of the TOPS System Unknown status NCT02234154
49 A Study to Evaluate the Safety and Effectiveness of the TOPS System Unknown status NCT01933607
50 Prospective Study of Minimally Invasive Spinal Fusion Surgery for the Treatment of Spondylolisthesis, Degenerative Disk Disease, Spinal Stenosis and Degenerative Scoliosis Unknown status NCT01045473

Search NIH Clinical Center for Spondylolisthesis

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spondylolisthesis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spondylolisthesis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spondylolisthesis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spondylolisthesis

Genetic Tests for Spondylolisthesis

Anatomical Context for Spondylolisthesis

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolisthesis:

Set Of Vertebrae

MalaCards organs/tissues related to Spondylolisthesis:

Bone, Testes, Bone Marrow, Spinal Cord, Kidney, Colon, Brain

Publications for Spondylolisthesis

Articles related to Spondylolisthesis:

(show top 50) (show all 5036)
# Title Authors PMID Year
Familial spondylolisthesis of the axis vertebra. 61 56
3536939 1986
Family study of spondylolysis and spondylolisthesis. 56 61
6761366 1982
A family with spondylolisthesis. 56 61
511891 1979
Familial occurrence of lumbar spondylolysis and spondylolisthesis. 61 56
668183 1978
Fatigue fracture: the basic lesion is inthmic spondylolisthesis. 61 56
1123367 1975
A family with spondylolisthesis. 56 61
5413907 1970
Hereditary spondylolisthesis and spina bifida. Report of a family in which the lesion is transmitted as an autosomal dominant through three generations. 56 61
5336847 1967
The etiology of spondylolisthesis. 56 61
14040287 1962
Examination of the possibility that certain skeletal characters predispose to defects in the lumbar neural arches. 56
13374901 1956
[The age incidence of neural-arch defects in Alaskan natives, considered from the standpoint of etiology]. 56
13108895 1953
A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 54 61
15672240 2005
A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. 61 54
15534410 2004
A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 54 61
12908103 2003
Cortical bone trajectory instrumentation provides favorable perioperative outcomes compared to pedicle screws for single-level lumbar spinal stenosis and degenerative spondylolisthesis. 61
32382216 2020
Magnetic resonance imaging findings of the lumbar spine, back symptoms and physical function among male adult patients with Scheuermann's disease. 61
32139999 2020
Lumbar intervertebral disc mRNA sequencing identifies the regulatory pathway in patients with disc herniation and spondylolisthesis. 61
32240779 2020
Percutaneous transforaminal endoscopic decompression for lumbar spinal stenosis with degenerative spondylolisthesis in the elderly. 61
32446122 2020
Etiology-Based Classification of Adjacent Segment Disease Following Lumbar Spine Fusion. 61
32523480 2020
Minimally Invasive Spine Lumbar Surgery in Obese Patients: A Systematic Review and Meta-Analysis. 61
32523485 2020
Predictors of the Best Outcomes Following Minimally Invasive Surgery for Grade 1 Degenerative Lumbar Spondylolisthesis. 61
32497184 2020
Epidural Steroid Injections for Management of Degenerative Spondylolisthesis: Little Effect on Clinical Outcomes in Operatively and Nonoperatively Treated Patients. 61
32555000 2020
Results of Decompression Alone in Patients with Lumbar Spinal Stenosis and Degenerative Spondylolisthesis: A Minimum 5-Year Follow-up. 61
32489540 2020
Evaluation of lumbar fusion using the anterior to psoas approach for the treatment of L5/S1 spondylolisthesis. 61
32501966 2020
Systematic Review of Outcomes Following 10-Year Mark of Spine Patient Outcomes Research Trial (SPORT) for Degenerative Spondylolisthesis. 61
32205705 2020
Comparison of Minimal Invasive Versus Biportal Endoscopic Transforaminal Lumbar Interbody Fusion for Single-level Lumbar Disease. 61
32496311 2020
Clinical Significance of Radiologic Improvement Following Single-Level Oblique Lateral Interbody Fusion With Percutaneous Pedicle Screw Fixation. 61
32501518 2020
Indirect Decompression Using Lateral Lumbar Interbody Fusion for Restenosis after an Initial Decompression Surgery. 61
31906613 2020
Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway. 61
32151764 2020
Comparison of the Prevalence of Low Back Pain and Related Spinal Diseases among Smokers and Nonsmokers: Using Korean National Health Insurance Database. 61
32489542 2020
Full Percutaneous Treatment of Degenerative Disc Disease with Intradiscal Lumbar Interbody Fusion and Posterior Stabilization: Preliminary Results. 61
32342158 2020
Trends in Anterior Lumbar Interbody Fusion in the United States: A MarketScan Study From 2007 to 2014. 61
31609798 2020
Effect of Surgical Setting on Hospital-Reported Outcomes for Elective Lumbar Spinal Procedures: Tertiary Versus Community Hospitals. 61
32435555 2020
Complication profile associated with S1 pedicle subtraction osteotomy compared with 3-column osteotomies at other thoracolumbar levels for adult spinal deformity: series of 405 patients with 9 S1 osteotomies. 61
32559748 2020
[The Facet Wedge: a minimally invasive technique for posterior segmental intra-articular fusion]. 61
32179944 2020
[Minimally invasive stand-alone fusion of the lumbosacral junction]. 61
32468147 2020
Fusion rate for stand-alone lateral lumbar interbody fusion: a systematic review. 61
32535072 2020
Simultaneous single-position lateral interbody fusion and percutaneous pedicle screw fixation using O-arm-based navigation reduces the occupancy time of the operating room. 61
32239355 2020
Predicting prolonged opioid prescriptions in opioid-naïve lumbar spine surgery patients. 61
31901553 2020
Lumbar spondylolisthesis associated with systemic sclerosis-related spinal calcinosis: an unusual clinical case. 61
32556288 2020
Is Reduction and Fusion Required for High-grade Spondylolisthesis? 61
32554987 2020
Ipsilateral Pedicle Stress Fracture After Endoscopic Foraminal Decompression for Patient with Isthmic Spondylolisthesis. 61
32145413 2020
Reduction versus In Situ Fusion for Adult High-Grade Spondylolisthesis: A Systematic Review and Meta-Analysis. 61
32179186 2020
Grade V Thoracic Spondylolisthesis in Neurofibromatosis Type 1: Case Report and Literature Review. 61
32201295 2020
Inter-observer Variance and Patient Heterogeneity Influencing The Treatment of Grade I Spondylolisthesis. 61
32534135 2020
Microendoscopic discectomy versus minimally invasive transforaminal lumbar interbody fusion for lumbar spinal stenosis without spondylolisthesis. 61
32541527 2020
Minimally invasive surgery for low-grade spondylolisthesis: percutaneous endoscopic or oblique lumbar interbody fusion. 61
32551889 2020
Fusion in situ versus reduction for spondylolisthesis treatment: grading the evidence through a meta-analysis. 61
32510149 2020
Sagittally Balanced Degenerative Spondylolisthesis Patients With Increased Sacral Slope and Greater Lumbar Lordosis Experience Less Back Pain After Short-Segment Lumbar Fusion Surgery. 61
31913174 2020
The Influence of Cervical Spondylolisthesis on Clinical Presentation and Surgical Outcome in Patients With DCM: Analysis of a Multicenter Global Cohort of 458 Patients. 61
32435566 2020
Comparison of Outcomes of Oblique Lateral Interbody Fusion with Percutaneous Posterior Fixation in Lateral Position and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Degenerative Spondylolisthesis. 61
32521951 2020

Variations for Spondylolisthesis

Expression for Spondylolisthesis

Search GEO for disease gene expression data for Spondylolisthesis.

Pathways for Spondylolisthesis

GO Terms for Spondylolisthesis

Cellular components related to Spondylolisthesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TTR TSKU MMP3 KLK8 GDF5 CRP
2 extracellular region GO:0005576 9.4 TTR TSKU SMR3A MMP3 KLK8 GDF5

Biological processes related to Spondylolisthesis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.78 TTR MMP3 COL9A3 ACAN
2 response to estradiol GO:0032355 9.71 PTGS2 ESR1 BMP7
3 positive regulation of neuron differentiation GO:0045666 9.69 GDF5 BMP7 BMP2
4 BMP signaling pathway GO:0030509 9.67 GDF5 BMP7 BMP2
5 cartilage development GO:0051216 9.61 GDF5 BMP7 BMP2
6 response to vitamin D GO:0033280 9.55 PTGS2 BMP7
7 positive regulation of brown fat cell differentiation GO:0090336 9.52 PTGS2 BMP7
8 SMAD protein signal transduction GO:0060395 9.5 GDF5 BMP7 BMP2
9 regulation of neuroinflammatory response GO:0150077 9.46 PTGS2 MMP3
10 negative regulation of blood vessel diameter GO:0097756 9.4 PTGS2 CRP
11 mesenchymal cell differentiation GO:0048762 9.37 BMP7 BMP2
12 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.26 ESR1 BMP7
13 mesenchyme development GO:0060485 9.16 BMP7 BMP2
14 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.13 GDF5 BMP7 BMP2
15 negative regulation of cell cycle GO:0045786 8.8 PTGS2 BMP7 BMP2

Molecular functions related to Spondylolisthesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BMP receptor binding GO:0070700 8.62 BMP7 BMP2

Sources for Spondylolisthesis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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