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MCID: SPN029
MIFTS: 41

Spondylolysis

Categories: Bone diseases
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Aliases & Classifications for Spondylolysis

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MalaCards integrated aliases for Spondylolysis:

Name: Spondylolysis 11 53 43 14 16 71 75 31 33
Acquired Spondylolysis 33

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:2300
MeSH 43 D013169
NCIt 49 C35034
SNOMED-CT 68 203688008
ICD10 31 M43.0
UMLS 71 C0038018
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Summaries for Spondylolysis

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Disease Ontology: 11 A bone structure disease that involves a defect located in lumbar vertebral column.

MalaCards based summary: Spondylolysis, also known as acquired spondylolysis, is related to spondylolisthesis and degenerative disc disease, and has symptoms including back pain An important gene associated with Spondylolysis is SLC26A2 (Solute Carrier Family 26 Member 2), and among its related pathways/superpathways are Extracellular matrix organization and Endochondral ossification. The drugs Bupivacaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include lumbar vertebral column, bone and bone marrow, and related phenotypes are growth/size/body region and limbs/digits/tail

Wikipedia: 75 Spondylolysis is a defect or stress fracture in the pars interarticularis of the vertebral arch. The... more...
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Related Diseases for Spondylolysis

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Diseases related to Spondylolysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 spondylolisthesis 31.3 PTH LSS GDF5 BMP7 BMP2 ACAN
2 degenerative disc disease 30.4 GDF5 BMP2 ACAN
3 arthropathy 30.1 BMP7 BMP2 ACAN
4 osteochondrosis 30.0 PTH BMP2 ACAN
5 spondylosis 29.9 PTH LSS GDF5 BMP2 ACAN
6 exostosis 29.9 GDF5 BMP2 ACAN
7 discitis 29.7 MED31 ACAN
8 diastrophic dysplasia 29.7 SLC26A2 BMP2
9 osteoarthritis 29.7 GDF5 CTSK BMP2 ACAN
10 osteonecrosis 29.7 PTH BMP7 BMP2
11 brittle bone disorder 29.6 PTH CTSK BMP7 BMP2 ACAN
12 klippel-feil syndrome 29.6 TBX6 GDF5
13 endosteal hyperostosis, autosomal dominant 29.6 PTH CTSK BMP2
14 back pain 10.8
15 neural tube defects 10.6
16 meningocele 10.6
17 tethered spinal cord syndrome 10.6
18 spina bifida occulta 10.5
19 scoliosis 10.5
20 radiculopathy 10.4
21 intervertebral disc disease 10.3
22 idiopathic scoliosis 10.3
23 cardiomyopathy, familial restrictive, 3 10.2 BMP7 BMP2
24 hypochondrogenesis 10.2 SLC26A2 ACAN
25 dental pulp necrosis 10.2 BMP7 BMP2
26 achondrogenesis, type ii 10.2 SLC26A2 ACAN
27 achondrogenesis 10.2 SLC26A2 ACAN
28 spinal cord disease 10.2
29 synostoses, tarsal, carpal, and digital 10.1 GDF5 BMP7
30 dental pulp disease 10.1 BMP7 BMP2
31 osteochondritis dissecans 10.1 BMP7 BMP2 ACAN
32 tarsal-carpal coalition syndrome 10.1 GDF5 BMP7
33 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.1
34 scoliosis, isolated 1 10.1
35 osteopetrosis 10.1
36 cleidocranial dysplasia 1 10.1 CTSK BMP7 BMP2
37 acromesomelic dysplasia 1 10.0 GDF5 ACAN
38 acromesomelic dysplasia 10.0 GDF5 ACAN
39 osteoid osteoma 10.0
40 fanconi anemia, complementation group e 10.0
41 spinal disease 10.0
42 cerebral palsy 10.0
43 spinal stenosis 10.0
44 47 xxx syndrome 10.0
45 chiari malformation 10.0
46 proximal symphalangism 10.0 GDF5 BMP7 BMP2
47 fibrochondrogenesis 10.0 GDF5 BMP2 ACAN
48 cartilage disease 10.0 GDF5 BMP2 ACAN
49 diffuse idiopathic skeletal hyperostosis 10.0 PTH LSS BMP2
50 osseous heteroplasia, progressive 10.0 PTH BMP7 BMP2

Graphical network of the top 20 diseases related to Spondylolysis:



Diseases related to Spondylolysis
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Symptoms & Phenotypes for Spondylolysis

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UMLS symptoms related to Spondylolysis:


back pain

MGI Mouse Phenotypes related to Spondylolysis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10 ACAN ATL2 BMP2 BMP7 CTSK GDF5
2 limbs/digits/tail MP:0005371 9.97 ACAN BMP2 BMP7 CTSK GDF5 MED31
3 craniofacial MP:0005382 9.7 ACAN BMP2 BMP7 CTSK MED31 PTH
4 skeleton MP:0005390 9.61 ACAN BMP2 BMP7 CTSK GDF5 MED31
5 mortality/aging MP:0010768 9.4 ACAN ATL2 BMP2 BMP7 GDF5 LSM3
Sources

Drugs & Therapeutics for Spondylolysis

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Drugs for Spondylolysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2 Anesthetics Phase 4
3 Anesthetics, Local Phase 4
4 Pharmaceutical Solutions Phase 4
5
Dexmedetomidine Approved, Experimental, Vet_approved Phase 2, Phase 3 86347-14-0, 113775-47-6 68602 5311068
6 Neurotransmitter Agents Phase 2, Phase 3
7 Adrenergic alpha-Agonists Phase 2, Phase 3
8 Adrenergic Agonists Phase 2, Phase 3
9 Adrenergic Agents Phase 2, Phase 3
10 Hypnotics and Sedatives Phase 2, Phase 3
11 Analgesics, Non-Narcotic Phase 2, Phase 3
12 Analgesics Phase 2, Phase 3
13
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
14
Tannic acid Approved 1401-55-4 16129878 16129778

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study Terminated NCT03514277 Phase 4 Exparel;Bupivacaine
2 Immune Effect of Dexmedetomidine as Immunomodulatory Anesthesic Agent in Patients Undergoing to Spinal Fusion: a Double-blind, Randomized and Placebo-controlled Clinical Trial Unknown status NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo
3 Direct Repair Surgery for Spondylolysis of Lumbar in Young Population Completed NCT02129374
4 Back in the Game: A Pilot Study Assessing an Immediate Functional Progression Program in Athletes With a Spondylolysis. Completed NCT03237104
5 Effects of Low-intensity Pulsed Ultrasound on Pain and Functional Disability in Patients With Lumbar Spondylolysis: A Randomized Controlled Trial Completed NCT04814979
6 Rest Before Physical Therapy in Adolescents With Active Spondylolysis and Spondylolisthesis. Completed NCT02332200
7 The Addition of a Pilates Program for Short-Term Improvements in Self Report and Physical Functions With Patients With Spondylolysis or Spondylolisthesis: A Randomized Clinical Trial Completed NCT01711203
8 Feasibility of Using Functional Progression to Guide the Treatment of Adolescent Low Back Pain Completed NCT02861456
9 Treatment of Spondylolysis With Soft Spinal Brace vs. Boston Brace in Pediatric Patients. A Clinical Trial Recruiting NCT03675152
10 Back in the Game: An Immediate Functional Progression Program for Adolescent Athletes With Spondylolysis: A Multi-Center Randomized Pilot Trial Recruiting NCT05505981
11 Efficacy of a Human Amniotic Tissue-derived Allograft, NuCel, in Patients Undergoing Posteriolateral Lumbar Fusions for Degenerative Disc Disease Terminated NCT02070484
12 A Multi-Center Clinical Investigation of Slotted Hole Versus Fixed Hole C-Tekâ„¢ Anterior Cervical Plates Terminated NCT00585923

Search NIH Clinical Center for Spondylolysis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Baclofen

Cochrane evidence based reviews: spondylolysis

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Genetic Tests for Spondylolysis

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Anatomical Context for Spondylolysis

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Organs/tissues related to Spondylolysis:

FMA: Lumbar Vertebral Column
MalaCards : Bone, Bone Marrow, Spinal Cord
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Publications for Spondylolysis

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Articles related to Spondylolysis:

(show top 50) (show all 1546)
# Title Authors PMID Year
1
Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. 53 62
17669279 2007
2
Developing clinical algorithm for identifying acute lumbar spondylolysis in elementary school children - Classification and regression tree analysis. 62
35343399 2022
3
Clinical characteristics of early-stage lumbar spondylolysis detected by magnetic resonance imaging in male adolescent baseball players. 62
36396506 2022
4
Clinical evaluation of the efficacy of a new bone cement-injectable cannulated pedicle screw in the treatment of spondylolysis-type lumbar spondylolisthesis with osteoporosis: a retrospective study. 62
36329431 2022
5
A superior articular process morphology of 5th lumbar vertebra prone to screws placement failure: an anatomical study of 299 patients. 62
36434721 2022
6
Clinical Practice Patterns of Isthmic Spondylolysis in Young Athletes: A Survey of Pediatric Research in Sports Medicine Members. 62
36342395 2022
7
Incidence, prevalence and risk factors for low back pain in adolescent athletes: a systematic review and meta-analysis. 62
36150752 2022
8
Incidence and risk factors of spinal cord stimulation for persistent or recurrent pain after lumbar spine surgery: a population-based study. 62
35713719 2022
9
Management of lumbar spondylolysis in the adolescent athlete: a review of over 200 cases. 62
35504566 2022
10
Low Back Pain and Lumbar Degeneration in Japanese Professional Baseball Players. 62
36250034 2022
11
[Case-control study on endplate injury of lumbar spine with two different intervertebral fusion methods]. 62
36280409 2022
12
Degenerative Grade 3 Spondylolisthesis Management: A Case Report and Literature Review. 62
36284806 2022
13
Posterior lumbar interbody fusion for dysplastic lumbar spondylolisthesis with high-grade slippage in two adolescent siblings: two case reports. 62
36050711 2022
14
Rates of Return to Sports and Recurrence in Pediatric Athletes after Conservative Treatment for Lumbar Spondylolysis. 62
36348674 2022
15
Conservative Treatment and Unfavorable Factors to Bone Healing of "Pre-lysis"-Stage Lumbar Spondylolysis in Adolescents. 62
35989507 2022
16
Large Lumbar Lordosis and Coronal Deformity Angular Ratio Are Risk Factors for Adolescent Idiopathic Scoliosis in Patients With Lumbar Spondylolysis. 62
35462074 2022
17
Clinical Results of Restoration of Pars Interarticularis Defect in Adults with Percutaneous Intralaminar Screw Fixation. 62
35552035 2022
18
A Review of Treatment for Acute and Chronic Pars Fractures in the Lumbar Spine. 62
35499747 2022
19
Elastic Lumbar Support versus Rigid Thoracolumbar Orthosis for Acute Pediatric Spondylolysis. A Prospective Controlled Study. 62
35834380 2022
20
Utility of ultrasonography in the diagnosis of lumbar spondylolysis in adolescent patients. 62
35864027 2022
21
CURRENT CLINICAL CONCEPTS: Management of Common Lumbar Spine Posterior Column Disorders. 62
35788849 2022
22
Direct Pars Repair with Cannulated Screws in Adults: A Case Series and Systematic Literature Review. 62
35367391 2022
23
Frequent fractures and sclerotic thick bands on physes related to oral alendronate treatments. 62
35571577 2022
24
Application of a new anatomic hook-rod-pedicle screw system in young patients with lumbar spondylolysis: A pilot study. 62
35979102 2022
25
Congenital spondylolytic spondylolisthesis of the cervical spine: A case report and literature review. 62
35464803 2022
26
The use of bracing in the management of lumbar spondylolysis. 62
35014189 2022
27
Comparison of two internal fixation systems in lumbar spondylolysis by finite element methods. 62
35272148 2022
28
Risk factor analysis of disc and facet joint degeneration after intersegmental pedicle screw fixation for lumbar spondylolysis. 62
35459170 2022
29
Contralateral Recurrence of a Lumbar Juxtafacet Cyst Following Spontaneous Resolution. 62
35633023 2022
30
Lateral bending differentiates early-stage spondylolysis from nonspecific low back pain in adolescents. 62
35149279 2022
31
Effects of low-intensity pulsed ultrasound on pain and functional disability in patients with early-stage lumbar spondylolysis: A randomized controlled trial. 62
35500960 2022
32
Association of spinal anomalies with spondylolysis and spina bifida occulta. 62
35237865 2022
33
Assessing a child or adolescent with low back pain is different to assessing an adult with low back pain. 62
35218582 2022
34
Diagnosis and Management of Spondylolysis and Spondylolisthesis in Children. 62
35611834 2022
35
A delayed diagnosis of high-grade spondylolisthesis. 62
35192553 2022
36
Spinal Curvatures, Deformities, and the Level of Disability in People with Bilateral Spastic Cerebral Palsy Living in South Africa; A 6-Year Follow-Up Study During Adulthood. 62
34653375 2022
37
Comparison of L5 pedicle morphology in patients with and without L5 spondylolysis. 62
34881820 2022
38
Is Increased Kicking Leg Iliopsoas Muscle Tightness a Predictive Factor for Developing Spondylolysis in Adolescent Male Soccer Players? 62
33844489 2022
39
Characteristics of recurrent cases after conservative therapy in adolescent lumbar spondylolysis. 62
35256699 2022
40
Role of low-intensity pulsed ultrasound on lumbar spondylolysis: A systematic review. 62
35320236 2022
41
Use of Recombinant Human Bone Morphogenetic Protein-2 With Iliac Crest Bone Graft Instead of Iliac Crest Bone Graft Alone in Lumbar Spondylolysis. 62
34654776 2022
42
Union evaluation of lumbar spondylolysis using MRI and CT in adolescents treated conservatively. 62
33597077 2022
43
Conservative treatment of spondylolysis involving exercise initiated early and sports activities resumed with a lumbar-sacral brace. 62
33846064 2022
44
Spondylolysis of the Thoracic Spine with Instability: A Rare Cause for Myelopathy. 62
35108231 2022
45
Non-Isthmic Spondylolysis Imaging Features: A Case Report. 62
36199724 2022
46
Pediatric cervical kyphosis in the MRI era (1984-2008) with long-term follow up: literature review. 62
34806157 2022
47
The influence of spinal position on imaging findings: an observational study of thoracolumbar spine upright MRI in elite gymnasts. 62
34613494 2022
48
Sacropelvic Parameters and L5 Spondylolysis: Computed Tomography Analysis. 62
33687859 2022
49
Retrospective Comparative Study of Pedicle Screw Fixation via Quadrant Retractor and Buck's Technique in the Treatment of Adolescent Spondylolysis. 62
34881509 2022
50
Lumbar Pedicular Stress Fracture Post-laminectomy: a Case Report. 62
36247353 2022
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Variations for Spondylolysis

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Expression for Spondylolysis

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Search GEO for disease gene expression data for Spondylolysis.
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Pathways for Spondylolysis

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Pathways related to Spondylolysis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Extracellular matrix organization 66
Show member pathways
 12 GDF5 CTSK BMP7 BMP2 ACAN
2
Endochondral ossification 74
Show member pathways
 11.6 PTH BMP7 ACAN
3
Elastic fibre formation 66
Show member pathways
 11.34 GDF5 BMP7 BMP2
4
Clock-controlled autophagy in bone metabolism 74
11.23 PTH CTSK BMP2
5
Mesenchymal Stem Cells and Lineage-specific Markers 65
11 PTH GDF5 BMP7 BMP2 ACAN
6
Differentiation of white and brown adipocyte 74
10.8 BMP7 BMP2
7
Cardiomyocyte Differentiation through BMP Receptors 64
10.71 BMP7 BMP2
Sources

GO Terms for Spondylolysis

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Biological processes related to Spondylolysis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 BMP signaling pathway GO:0030509 9.99 GDF5 BMP7 BMP2
2 positive regulation of neuron differentiation GO:0045666 9.97 GDF5 BMP7 BMP2
3 ossification GO:0001503 9.93 SLC26A2 BMP7 BMP2
4 response to vitamin D GO:0033280 9.85 PTH BMP7
5 SMAD protein signal transduction GO:0060395 9.85 GDF5 BMP7 BMP2
6 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.8 GDF5 BMP7 BMP2
7 endocardial cushion formation GO:0003272 9.78 BMP7 BMP2
8 cartilage development GO:0051216 9.76 BMP2 BMP7 GDF5
9 positive regulation of SMAD protein signal transduction GO:0060391 9.73 BMP7 BMP2
10 positive regulation of epithelial cell differentiation GO:0030858 9.73 BMP2 BMP7
11 mesenchymal cell differentiation GO:0048762 9.71 BMP7 BMP2
12 positive regulation of ossification GO:0045778 9.7 PTH BMP2
13 ameloblast differentiation GO:0036305 9.56 BMP2 BMP7
14 mesenchyme development GO:0060485 9.46 BMP2 BMP7
15 positive regulation of bone mineralization GO:0030501 9.43 PTH BMP7 BMP2
16 skeletal system development GO:0001501 9.23 PTH BMP7 BMP2 ACAN

Molecular functions related to Spondylolysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BMP receptor binding GO:0070700 8.92 BMP7 BMP2
Sources

Sources for Spondylolysis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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