Aliases & Classifications for Spondylolysis

MalaCards integrated aliases for Spondylolysis:

Name: Spondylolysis 12 54 44 15 17 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:2300
MeSH 44 D013169
NCIt 50 C35034
SNOMED-CT 67 203688008
ICD10 32 M43.0
UMLS 70 C0038018

Summaries for Spondylolysis

Disease Ontology : 12 A bone structure disease that involves a defect located in lumbar vertebral column.

MalaCards based summary : Spondylolysis is related to spondylolisthesis and spondylosis, and has symptoms including back pain An important gene associated with Spondylolysis is SLC26A2 (Solute Carrier Family 26 Member 2), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Bupivacaine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include lumbar vertebral column, bone and bone marrow, and related phenotype is limbs/digits/tail.

Wikipedia : 73 Spondylolysis (spon-dee-low-lye-sis) is defined as a defect or stress fracture in the pars... more...

Related Diseases for Spondylolysis

Diseases related to Spondylolysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 spondylolisthesis 31.2 GDF5 BMP7 BMP2 ACAN
2 spondylosis 30.1 BMP2 ACAN
3 radiculopathy 30.1 BMP2 ACAN
4 spinal stenosis 29.9 BMP7 ACAN
5 degenerative disc disease 29.8 GDF5 BMP2 ACAN
6 diastrophic dysplasia 29.5 SLC26A2 BMP2
7 brittle bone disorder 29.2 CTSK BMP7 BMP2 ACAN
8 ankylosis 29.2 GDF5 BMP2
9 exostosis 29.1 GDF5 BMP2 ACAN
10 back pain 10.8
11 neural tube defects 10.6
12 spina bifida occulta 10.5
13 scoliosis 10.4
14 idiopathic scoliosis 10.2
15 skeletal dysplasias 10.1 SLC26A2 CTSK
16 achondrogenesis 10.1 SLC26A2 ACAN
17 hypochondrogenesis 10.1 SLC26A2 ACAN
18 osteopetrosis 10.1
19 47,xyy 10.1
20 osteoid osteoma 10.0
21 spinal disease 10.0
22 cerebral palsy 10.0
23 chiari malformation 10.0
24 vestibular nystagmus 10.0 SLC7A4 SLC7A3
25 spondyloepiphyseal dysplasia with congenital joint dislocations 10.0 SLC26A2 ACAN
26 legg-calve-perthes disease 9.9
27 scoliosis, isolated 1 9.9
28 syringomyelia, noncommunicating isolated 9.9
29 chiari malformation type ii 9.9
30 pycnodysostosis 9.9
31 aging 9.9
32 rickets 9.9
33 tethered spinal cord syndrome 9.9
34 quadriplegia 9.9
35 syringomyelia 9.9
36 spinal cord injury 9.9
37 achondrogenesis, type ii 9.9 SLC26A2 GDF5 ACAN
38 calcific tendinitis 9.9 CTSK BMP2
39 pseudoachondroplasia 9.9 SLC26A2 ACAN
40 tooth resorption 9.9 CTSK BMP2
41 brachydactyly, type a1, b 9.9 GDF5 BMP2
42 osseous heteroplasia, progressive 9.8 BMP7 BMP2
43 spondyloarthropathy 1 9.8
44 chiari malformation type i 9.8
45 hand skill, relative 9.8
46 polykaryocytosis inducer 9.8
47 scheuermann disease 9.8
48 spondylosis, cervical 9.8
49 down syndrome 9.8
50 diastematomyelia 9.8

Graphical network of the top 20 diseases related to Spondylolysis:



Diseases related to Spondylolysis

Symptoms & Phenotypes for Spondylolysis

UMLS symptoms related to Spondylolysis:


back pain

MGI Mouse Phenotypes related to Spondylolysis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.02 BMP2 BMP7 CTSK GDF5 SLC26A2

Drugs & Therapeutics for Spondylolysis

Drugs for Spondylolysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2 Pharmaceutical Solutions Phase 4
3 Anesthetics Phase 4
4 Anesthetics, Local Phase 4
5
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 113775-47-6 5311068 68602
6 Analgesics, Non-Narcotic Phase 2, Phase 3
7 Adrenergic alpha-Agonists Phase 2, Phase 3
8 Hypnotics and Sedatives Phase 2, Phase 3
9 Neurotransmitter Agents Phase 2, Phase 3
10 Analgesics Phase 2, Phase 3
11 Adrenergic Agents Phase 2, Phase 3
12 Adrenergic Agonists Phase 2, Phase 3
13
tannic acid Approved 1401-55-4
14
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study Terminated NCT03514277 Phase 4 Exparel;Bupivacaine
2 Immune Effect of Dexmedetomidine as Immunomodulatory Anesthesic Agent in Patients Undergoing to Spinal Fusion: a Double-blind, Randomized and Placebo-controlled Clinical Trial Unknown status NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo
3 Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study. Unknown status NCT03407560
4 Effects of Low-intensity Pulsed Ultrasound on Pain and Functional Disability in Patients With Lumbar Spondylolysis: A Randomized Controlled Trial Completed NCT04814979
5 Direct Repair Surgery for Spondylolysis of Lumbar in Young Population Completed NCT02129374
6 The Addition of a Pilates Program for Short-Term Improvements in Self Report and Physical Functions With Patients With Spondylolysis or Spondylolisthesis: A Randomized Clinical Trial Completed NCT01711203
7 Back in the Game: A Pilot Study Assessing an Immediate Functional Progression Program in Athletes With a Spondylolysis. Completed NCT03237104
8 Feasibility of Using Functional Progression to Guide the Treatment of Adolescent Low Back Pain Completed NCT02861456
9 Treatment of Spondylolysis With Soft Spinal Brace vs. Boston Brace in Pediatric Patients. A Clinical Trial Recruiting NCT03675152
10 Rest Before Physical Therapy in Adolescents With Active Spondylolysis and Spondylolisthesis. Active, not recruiting NCT02332200
11 A Multi-Center Clinical Investigation of Slotted Hole Versus Fixed Hole C-Tek™ Anterior Cervical Plates Terminated NCT00585923
12 Efficacy of a Human Amniotic Tissue-derived Allograft, NuCel, in Patients Undergoing Posteriolateral Lumbar Fusions for Degenerative Disc Disease Terminated NCT02070484

Search NIH Clinical Center for Spondylolysis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Baclofen

Cochrane evidence based reviews: spondylolysis

Genetic Tests for Spondylolysis

Anatomical Context for Spondylolysis

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolysis:

19
Lumbar Vertebral Column

MalaCards organs/tissues related to Spondylolysis:

40
Bone, Bone Marrow

Publications for Spondylolysis

Articles related to Spondylolysis:

(show top 50) (show all 1448)
# Title Authors PMID Year
1
Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. 54 61
17669279 2007
2
Is there a place for surgical repair in adults with spondylolysis or grade-I spondylolisthesis-A systematic review and treatment algorithm. 61
33757872 2021
3
Age-Specific Characteristics of Lumbopelvic Alignment in Patients with Spondylolysis: How Bilateral L5 Spondylolysis Influences Lumbopelvic Alignment During the Aging Process. 61
33385597 2021
4
Sacropelvic Parameters and L5 Spondylolysis: Computed Tomography Analysis. 61
33687859 2021
5
Union evaluation of lumbar spondylolysis using MRI and CT in adolescents treated conservatively. 61
33597077 2021
6
Masquerading Guillain-Barré syndrome: uncommon, in-hospital presentation of Miller-Fisher syndrome shadowed by secondary diseases. 61
33541995 2021
7
Minimally Invasive Approach Toward Percutaneous Direct Pars Repair: An Observational Study. 61
33307253 2021
8
An Alternative Model of Care for the Treatment of Adolescent Athletes with Extension-Based Low Back Pain: A Pilot Study. 61
33604151 2021
9
Inter-Disciplinary Conservative Management of Bilateral Non-United Lumbar Pars Defects in a Junior Elite Golfer. 61
33604152 2021
10
Influence of Spondylolysis on Clinical Presentations in Patients With Lumbar Degenerative Disease. 61
33564556 2021
11
Return to play after spondylolysis: An overview. 61
33487859 2021
12
Asymptomatic Degenerative Changes in the Lumbar Spine Among Professional Soccer Players. 61
33347092 2021
13
Low Specificity Limits Use of Test for Spondylolysis in Children and Adolescents. 61
33448776 2021
14
Factors associated with failure of bony union after conservative treatment of acute cases of unilateral lumbar spondylolysis. 61
33441118 2021
15
Adolescents with spondylolysis have lower SRS-22 scores than controls and peers with pre-operative idiopathic scoliosis. 61
32940877 2021
16
Direct reduction and repair of spondylolysis with grade 1 slip using the smiley face rod: a case report. 61
33442437 2021
17
Assessment of disability levels in patients with low back pain based on the type of lumbar spinal disorder. 61
33325383 2021
18
Orthopaedic medical examination for young amateur athletes: a repeated cross-sectional study from 2014 to 2018. 61
33436469 2021
19
Identifying Acute Lumbar Spondylolysis in Young Athletes with Low Back Pain: Retrospective Classification and Regression Tree Analysis. 61
33395023 2020
20
Does facet joint morphology affect the development of spondylolysis? 61
33362349 2020
21
Bone Healing in Adolescents with Bilateral L5 Spondylolysis with and without Preexisting Contralateral Terminal Spondylolysis. 61
33355849 2020
22
[Cervical spondylolysis : a rare fortuitous finding]. 61
33331698 2020
23
Comparing Surgical Treatments for Spondylolysis: Review on Current Research. 61
33298798 2020
24
CONSIDERATION OF SPORT DEMANDS FOR AN 18-YEAR-OLD LACROSSE PLAYER WITH RECALCITRANT SYMPTOMATIC SPONDYLOLYSIS: A CASE REPORT. 61
33344035 2020
25
A Novel Technique for Spondylolysis Repair With Pedicle Screws, Rod and Polyester Band: Case Report With Technical Note and Systematic Literature Review. 61
32947495 2020
26
Quantitative Assessment of Bone Marrow Edema in Adolescent Athletes with Lumbar Spondylolysis Using Contrast Ratio on Magnetic Resonance Imaging. 61
33189112 2020
27
Occupational influences on Spondylolysis and Spondylolisthesis in a cohort of 18-year-old male military conscripts. 61
33153454 2020
28
In Reply to the Letter to the Editor regarding "Symptomatic Unilateral Pediculolysis Associated with Contralateral Spondylolysis and Spondylolisthesis in Adults - Case Report and Review of Literature". 61
33167159 2020
29
Letter to the Editor Regarding "Symptomatic Unilateral Pediculolysis Associated with Contralateral Spondylolysis and Spondylolisthesis in Adults-Case Report and Review of Literature". 61
33167158 2020
30
Symptomatic Unilateral Pediculolysis Associated with Contralateral Spondylolysis and Spondylolisthesis in Adults-Case Report and Review of Literature. 61
32795684 2020
31
The Joe-Lin Operative Classification System for Pediatric Lumbosacral Spondylolysis and Spondylolisthesis. 61
32434018 2020
32
Characteristics and diagnostic factors associated with fresh lumbar spondylolysis in elementary school-aged children. 61
32737580 2020
33
Characteristics of adolescent lumbar spondylolysis with acute unilateral fatigue fracture and contralateral pseudoarthrosis. 61
33033537 2020
34
Bilateral paraspinal muscle flap closure technique for reduction of wound complications from posterior thoracolumbar spinal fusion: results of a series of 716 patients. 61
33065537 2020
35
Increased sagittal diameter of the vertebral arch aids in diagnosis of lumbar spondylolysis. 61
33112978 2020
36
A long-term follow-up study of spinal abnormalities and pain in adults with cerebral palsy and spastic diplegia more than 25 years after selective dorsal rhizotomy. 61
33065536 2020
37
Is Microendoscopic Discectomy Effective for Patients With Concomitant Lumbar Disc Herniation and Spondylolysis? 61
32707024 2020
38
Epidemiology, Treatment, and Performance-Based Outcomes in American Professional Baseball Players With Symptomatic Spondylolysis and Isthmic Spondylolisthesis. 61
32795194 2020
39
Comparison of symptomatic spondylolysis in young soccer and baseball players. 61
32883336 2020
40
Spontaneous Laminar Fracture during Successful Conservative Treatment of Lumbar Spondylolysis at the Adjacent Spinal Level: A Case Report. 61
33062565 2020
41
Development of a preliminary multivariable diagnostic prediction model for identifying active spondylolysis in young athletes with low back pain. 61
32534433 2020
42
Magnetic resonance imaging of the spine in a pediatric population: incidental findings. 61
33071373 2020
43
Percutaneous CT-guided lumbar trans-facet pedicle screw fixation in lumbar microinstability syndrome: feasibility of a novel approach. 61
32367350 2020
44
The Prevalence of Abnormalities in the Pediatric Spine on MRI: A Systematic Review and Meta-Analysis. 61
32355138 2020
45
Alleviation of Chronic Low Back Pain due to Bilateral Traumatic L4 Pars Interarticularis Fractures Relieved With Steroid Injections. 61
32953331 2020
46
A narrative review on spinal deformities in people with cerebral palsy: Measurement, norm values, incidence, risk factors and treatment. 61
32880305 2020
47
Non-discogenic low back pain treated with oxygen-ozone: outcome in selected applications. 61
33176414 2020
48
Back Pain in Children and Adolescents. 61
32603067 2020
49
[The Facet Wedge: a minimally invasive technique for posterior segmental intra-articular fusion]. 61
32179944 2020
50
Percutaneous endoscopic-assisted direct repair of pars defect without general anesthesia could be a satisfying treatment alternative for young patient with symptomatic lumbar spondylolysis: a technique note with case series. 61
32487055 2020

Variations for Spondylolysis

Expression for Spondylolysis

Search GEO for disease gene expression data for Spondylolysis.

Pathways for Spondylolysis

GO Terms for Spondylolysis

Biological processes related to Spondylolysis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.65 BMP7 BMP2 ACAN
2 ossification GO:0001503 9.63 SLC26A2 BMP7 BMP2
3 positive regulation of neuron differentiation GO:0045666 9.61 GDF5 BMP7 BMP2
4 odontogenesis of dentin-containing tooth GO:0042475 9.58 BMP7 BMP2
5 embryonic limb morphogenesis GO:0030326 9.57 GDF5 BMP7
6 negative regulation of cell cycle GO:0045786 9.56 BMP7 BMP2
7 positive regulation of epithelial to mesenchymal transition GO:0010718 9.55 BMP7 BMP2
8 positive regulation of cell differentiation GO:0045597 9.54 BMP7 BMP2
9 BMP signaling pathway GO:0030509 9.54 GDF5 BMP7 BMP2
10 epithelial to mesenchymal transition GO:0001837 9.52 BMP7 BMP2
11 cellular response to BMP stimulus GO:0071773 9.51 BMP7 BMP2
12 cartilage development GO:0051216 9.5 GDF5 BMP7 BMP2
13 positive regulation of bone mineralization GO:0030501 9.49 BMP7 BMP2
14 mesenchymal cell differentiation GO:0048762 9.4 BMP7 BMP2
15 endocardial cushion formation GO:0003272 9.26 BMP7 BMP2
16 mesenchyme development GO:0060485 9.16 BMP7 BMP2
17 SMAD protein signal transduction GO:0060395 9.13 GDF5 BMP7 BMP2
18 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 8.8 GDF5 BMP7 BMP2

Molecular functions related to Spondylolysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 GDF5 BMP7 BMP2
2 growth factor activity GO:0008083 9.33 GDF5 BMP7 BMP2
3 amino acid transmembrane transporter activity GO:0015171 9.32 SLC7A4 SLC7A3
4 BMP receptor binding GO:0070700 8.96 BMP7 BMP2
5 basic amino acid transmembrane transporter activity GO:0015174 8.62 SLC7A4 SLC7A3

Sources for Spondylolysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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