Aliases & Classifications for Spondylolysis

MalaCards integrated aliases for Spondylolysis:

Name: Spondylolysis 12 29 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2300
ICD10 33 M43.0 M43.00
MeSH 44 D013169
NCIt 50 C35034
SNOMED-CT 68 203688008 240221008
UMLS 73 C0038018

Summaries for Spondylolysis

Disease Ontology : 12 A bone structure disease that involves a defect located in lumbar vertebral column.

MalaCards based summary : Spondylolysis is related to spondylolisthesis and cervicitis, and has symptoms including back pain An important gene associated with Spondylolysis is SLC26A2 (Solute Carrier Family 26 Member 2), and among its related pathways/superpathways are Glucose / Energy Metabolism and TGF-beta signaling pathway (KEGG). The drugs Ketamine and Menthol have been mentioned in the context of this disorder. Affiliated tissues include lumbar vertebral column, bone and testes.

Wikipedia : 76 Spondylolysis (spon-dee-low-lye-sis) is defined as a defect or stress fracture in the pars... more...

Related Diseases for Spondylolysis

Diseases related to Spondylolysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 spondylolisthesis 31.4 BMP7 FTH1 GDF5
2 cervicitis 10.5
3 back pain 10.3
4 scoliosis 10.1
5 neural tube defects 10.1
6 aging 10.1
7 spina bifida occulta 10.1
8 brittle bone disorder 9.9
9 osteopetrosis 9.9
10 radiculopathy 9.9
11 chiari malformation type ii 9.9
12 osteoid osteoma 9.9
13 idiopathic scoliosis 9.9
14 syringomyelia 9.9
15 chiari malformation 9.9
16 proximal symphalangism 9.8 BMP7 GDF5
17 bone development disease 9.8 GDF5 SLC26A2
18 spondyloarthropathy 1 9.7
19 scoliosis, isolated 1 9.7
20 diastematomyelia 9.7
21 diastrophic dysplasia 9.7
22 pycnodysostosis 9.7
23 cerebral palsy 9.7
24 osteoarthritis 9.7
25 spinal stenosis 9.7
26 myelomeningocele 9.7
27 discitis 9.7
28 epidural abscess 9.7
29 spondylosis 9.7
30 cerebritis 9.7
31 aortic aneurysm 9.7
32 spondylitis 9.7
33 aneurysm 9.7
34 bone deterioration disease 9.4 BMP7 FTH1 GDF5
35 bone structure disease 9.4 BMP7 FTH1 GDF5
36 trehalase deficiency 8.9 BMP7 FUS SLC26A2

Graphical network of the top 20 diseases related to Spondylolysis:



Diseases related to Spondylolysis

Symptoms & Phenotypes for Spondylolysis

UMLS symptoms related to Spondylolysis:


back pain

Drugs & Therapeutics for Spondylolysis

Drugs for Spondylolysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
2
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
3
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
4
Pregabalin Approved, Illicit, Investigational Phase 4,Not Applicable 148553-50-8 5486971
5 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
6 Analgesics, Opioid Phase 4,Not Applicable
7 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
8 Anesthetics, Dissociative Phase 4
9 Anesthetics, General Phase 4
10 Anesthetics, Intravenous Phase 4
11 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
12 Excitatory Amino Acid Antagonists Phase 4
13 Excitatory Amino Acids Phase 4
14 Narcotics Phase 4,Not Applicable
15 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
16 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
17 Anti-Anxiety Agents Phase 4
18 Anticonvulsants Phase 4
19 calcium channel blockers Phase 4
20 Calcium, Dietary Phase 4
21 Psychotropic Drugs Phase 4
22 Tranquilizing Agents Phase 4
23
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 113775-47-6 68602 5311068
24 Adrenergic Agents Phase 2, Phase 3
25 Adrenergic Agonists Phase 2, Phase 3
26 Adrenergic alpha-2 Receptor Agonists Phase 2, Phase 3
27 Adrenergic alpha-Agonists Phase 2, Phase 3
28 Analgesics, Non-Narcotic Phase 2, Phase 3
29 Hypnotics and Sedatives Phase 2, Phase 3
30
Cisatracurium Approved Phase 2 96946-41-7
31
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
32
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
33
Remifentanil Approved Phase 2 132875-61-7 60815
34
Ropivacaine Approved Phase 2 84057-95-4 71273 175805
35
s 1 (combination) Phase 1, Phase 2,Phase 2,Not Applicable
36 Anesthetics, Local Phase 2
37 BB 1101 Phase 2
38 Dexamethasone acetate Phase 2 1177-87-3
39
Teriparatide Approved, Investigational Not Applicable 52232-67-4 16133850
40
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
41
Silicon Approved, Investigational Not Applicable 7440-21-3 4082203
42
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
43
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
44
Ketorolac Approved Not Applicable 74103-06-3, 66635-83-4 3826
45
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
46
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
47
Racepinephrine Approved Not Applicable 329-65-7 838
48
Gabapentin Approved, Investigational Not Applicable 60142-96-3 3446
49
Dimenhydrinate Approved Not Applicable 523-87-5 441281
50 tannic acid Approved, Nutraceutical Not Applicable

Interventional clinical trials:

(show top 50) (show all 125)
# Name Status NCT ID Phase Drugs
1 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
2 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
3 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
4 A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
5 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
6 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
7 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
8 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
9 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
10 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
11 Total Facet Arthroplasty System®(TFAS®) Clinical Trial Unknown status NCT00418197 Phase 3
12 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
13 Greenwich Lumbar Stenosis SLIP Study Completed NCT00109213 Phase 3
14 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
15 Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion Recruiting NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo
16 Peri-Incisional Drug Injection in Lumbar Spine Surgery Not yet recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
17 A Clinical Study of the Dynesys(R) Spinal System Terminated NCT00759057 Phase 3
18 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
19 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
20 Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion Completed NCT01106417 Phase 2
21 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy Completed NCT01097486 Phase 2
22 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion Completed NCT00996073 Phase 2
23 Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF) Completed NCT00549913 Phase 1, Phase 2
24 Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis Recruiting NCT03100032 Phase 1, Phase 2
25 Transverse Abdominis Plane Block for Anterior Approach Spine Surgery Recruiting NCT02884440 Phase 2 TAP block ropivacaine;TAP block placebo;General anesthesia
26 Safety Study of Mesenchymal Stem Cells and Spinal Fusion Active, not recruiting NCT01552707 Phase 1, Phase 2
27 CopiOs Posterolateral Fusion Procedure Terminated NCT01123850 Phase 2
28 Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion Withdrawn NCT00810212 Phase 1, Phase 2
29 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379 Not Applicable
30 Post-market Study of the TOPS™ System Unknown status NCT02234154 Not Applicable
31 Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures Unknown status NCT02171169
32 Post-market Study of the TOPS™ System Unknown status NCT01933607 Not Applicable
33 Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion Unknown status NCT01292252 Not Applicable
34 Dynesys Spinal System Post Market 522 Study Unknown status NCT01528072 Not Applicable
35 Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain Unknown status NCT01918943
36 Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression Unknown status NCT01338766 Not Applicable
37 Prospective Study of Minimally Invasive Spine Surgery Unknown status NCT01045473
38 Direct Repair Surgery for Spondylolysis of Lumbar in Young Population Completed NCT02129374 Not Applicable
39 The Addition of a Pilates Program for Short-Term Improvements in Patients With Spondylolysis or Spondylolisthesis Completed NCT01711203 Not Applicable
40 Intra- And Inter-operator Reliability Of Isometric Back And Abdominal Muscle Strength Testing In Healthy Controls And Persons With Nonspecific Chronic Low Back Pain. Completed NCT03571880 Not Applicable
41 Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease Completed NCT02070484 Not Applicable
42 New Robotic Assistance System for Spinal Fusion Surgery Completed NCT02558621 Not Applicable
43 Prospective Clinical Evaluation of the New Aegis Plate for Anterior Interbody Fusions Completed NCT00555659
44 Free Hand Lumbar Pedicular Screw Fixation Completed NCT03327298 Not Applicable
45 Valeo OL Interbody Fusion Devices for Posterior Lumbar Interbody Fusion SNAP Trial Completed NCT01557829 Not Applicable
46 Multimodal Perioperative Pain Management Completed NCT01513564 Not Applicable Postoperative epidural morphine;Local anaesthesia
47 XLIF® vs. MAS®TLIF for the Treatment of Symptomatic Lumbar Degenerative Spondylolisthesis With or Without Central Stenosis. Completed NCT01024699
48 SPONGIT: Comparison of Two Surgical Approaches in the Treatment of Degenerative Spondylolysthesis Completed NCT00869882 Not Applicable
49 Spinal Fusion and Rehabilitation Study Completed NCT00834015 Not Applicable
50 Posterior Lateral Fusion (PLF) With Dynesys Completed NCT00791180

Search NIH Clinical Center for Spondylolysis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: spondylolysis

Genetic Tests for Spondylolysis

Genetic tests related to Spondylolysis:

# Genetic test Affiliating Genes
1 Spondylolysis 29

Anatomical Context for Spondylolysis

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolysis:

19
Lumbar Vertebral Column

MalaCards organs/tissues related to Spondylolysis:

41
Bone, Testes, Bone Marrow

Publications for Spondylolysis

Articles related to Spondylolysis:

(show top 50) (show all 570)
# Title Authors Year
1
Osteoid Osteoma Can Occur at the Pars Interarticularis of the Lumbar Spine, Leading to Misdiagnosis of Lumbar Spondylolysis. ( 29479057 )
2018
2
Efficacy and outcome predictors of fluoroscopy-guided facet joint injection for spondylolysis. ( 29396693 )
2018
3
Lumbar Hyperextension in Baseball Pitching: A Potential Cause of Spondylolysis. ( 29809066 )
2018
4
Spondylolysis and spondylolisthesis: A review of the literature. ( 29881164 )
2018
5
Biomechanical analysis of spino-pelvic postural configurations in spondylolysis subjected to various sport-related dynamic loading conditions. ( 29926211 )
2018
6
Mild (not severe) disc degeneration is implicated in the progression of bilateral L5 spondylolysis to spondylolisthesis. ( 29609581 )
2018
7
Multilevel Spondylolysis Repair Using the "Smiley Face" Technique with 3-Dimensional Intraoperative Spinal Navigation. ( 29054782 )
2018
8
High defect stage, contralateral defects, and poor flexibility are negative predictive factors of bone union in pediatric and adolescent athletes with spondylolysis. ( 29593182 )
2018
9
Predictive Factors for the Outcome of Surgical Treatment of Lumbar Spondylolysis in Young Sporting Individuals. ( 29662741 )
2018
10
A New Minimally Invasive Technique for Primary Unstable C2 Spondylolysis in an 8-Year-Old Child: A Case Report and Review of the Literature. ( 29654954 )
2018
11
Factors Associated with the Symptoms of Young Adults with L5 Spondylolysis. ( 29879775 )
2018
12
Diagnosis of Spondylolysis and Spondylolisthesis Is Delayed Six Months After Seeing Nonorthopedic Providers. ( 29735135 )
2018
13
A comparison of the techniques of direct pars interarticularis repairs for spondylolysis and low-grade spondylolisthesis: a meta-analysis. ( 29290131 )
2018
14
Return to Play in Adolescent Athletes With Symptomatic Spondylolysis Without Listhesis: A Meta-Analysis. ( 29662750 )
2018
15
Acquired spondylolysis and spinopelvic sagittal alignment. ( 29569131 )
2018
16
Double-level lumbar spondylolysis and spondylolisthesis: A retrospective study. ( 29548343 )
2018
17
Radiographic Analysis Of The Listhesis Associated With Lumbar Isthmic Spondylolysis. ( 29807187 )
2018
18
Imaging of Spondylolysis: The Evolving Role of Magnetic Resonance Imaging. ( 29428876 )
2018
19
Headless compression screw in the neuronavigation-guided and microscope-assisted treatment of spondylolysis. ( 28988667 )
2017
20
Spondylolysis in the past: A case study of hunter-gatherers from Southern Patagonia. ( 29198391 )
2017
21
Different fusion approaches for single-level lumbar spondylolysis have similar perioperative outcomes. ( 28591074 )
2017
22
Vertebral body bone mineral density in patients with lumbar spondylolysis: a quantitative CT study. ( 28765098 )
2017
23
Active stretching for lower extremity muscle tightness in pediatric patients with lumbar spondylolysis. ( 28373610 )
2017
24
Adolescent Spondylolysis: Management and Return to Play. ( 28594517 )
2017
25
Congenital double-level cervical spondylolysis: a case report and review of the literature. ( 28247078 )
2017
26
Pediatric spondylolysis/spinal stenosis and disc herniation: national trends in decompression and discectomy surgery evaluated through the Kids' Inpatient Database. ( 28643037 )
2017
27
Contralateral Spondylolysis and Fracture of the Lumbar Pedicle in a Young Athlete. ( 28542108 )
2017
28
Spondylolisthesis with spondylolysis in a 17-month-old: a case report. ( 29354748 )
2017
29
Minimally-Invasive versus Conventional Repair of Spondylolysis in Athletes: A Review of Outcomes and Return to Play. ( 29093794 )
2017
30
Lumbar Back Pain Secondary to Spondylolysis. ( 28471908 )
2017
31
Current Evidence Regarding Diagnostic Imaging Methods for Pediatric Lumbar Spondylolysis: A Report From the Scoliosis Research Society Evidence-Based Medicine Committee. ( 28259272 )
2017
32
Does the Prevalence of Spondylolysis and Spina Bifida Occulta Observed in Pediatric Patients Remain Stable in Adults? ( 28937467 )
2017
33
Benign Natural History of Spondylolysis in Adolescence With Midterm Follow-Up. ( 28259265 )
2017
34
Lumbar Spondylolysis And Spondylolisthesis ( 28846329 )
2017
35
Low-Intensity Pulsed Ultrasound for Early-Stage Lumbar Spondylolysis in Young Athletes. ( 29035987 )
2017
36
Lumbar spondylolysis: A report of four cases from two generations of a family. ( 28617180 )
2017
37
Indirect pars repair for pediatric isthmic spondylolysis: a case series. ( 29057347 )
2017
38
The Relationship Between Sacral Slope and Symptomatic IsthmicA Spondylolysis in a Cohort of High School Athletes: A Retrospective Analysis. ( 28993288 )
2017
39
Prevalence of Spondylolysis in Symptomatic Adolescent Athletes: An Assessment of Sport Risk in Nonelite Athletes. ( 29140811 )
2017
40
Properties of Paraspinal Muscles in Japanese High School Baseball Players With Terminal-Stage Lumbar Spondylolysis. ( 28673735 )
2017
41
Low-intensity pulsed ultrasound is effective for progressive-stage lumbar spondylolysis with MRI high-signal change. ( 28391380 )
2017
42
Degenerative Changes of the Facet Joints in Adults With Lumbar Spondylolysis. ( 28632562 )
2017
43
A minimal soft tissue damage approach of spondylolysis repair in athletes: preliminary report. ( 28497280 )
2017
44
Increased Lumbar Lordosis and Smaller Vertebral Cross-sectional Area are Associated with Spondylolysis. ( 29095410 )
2017
45
The prevalence of lumbar spondylolysis in young children: a retrospective analysis using CT. ( 29030702 )
2017
46
Poster 189 Multilevel Spondylolysis in An Adolescent Athlete: AA Case Report. ( 27672955 )
2016
47
Lumbar spondylolysis in the adolescent athlete. ( 27234265 )
2016
48
Long-Term Clinical Outcomes and Factors That Predict Poor Prognosis in Athletes After a Diagnosis of Acute Spondylolysis: A Retrospective Review With Telephone Follow-up. ( 27825292 )
2016
49
Prevalence of Symptomatic Lumbar Spondylolysis in Pediatric Patients. ( 27064777 )
2016
50
Is Preventative Long-Segment Surgery for Multi-Level Spondylolysis Necessary? A Finite Element Analysis Study. ( 26918333 )
2016

Variations for Spondylolysis

Expression for Spondylolysis

Search GEO for disease gene expression data for Spondylolysis.

Pathways for Spondylolysis

Pathways related to Spondylolysis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 FTH1 PGRMC1 SLC7A11
2 11.18 BMP7 GDF5
3
Show member pathways
11.02 BMP7 GDF5
4 10.23 FTH1 SLC7A11

GO Terms for Spondylolysis

Biological processes related to Spondylolysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BMP signaling pathway GO:0030509 9.46 BMP7 GDF5
2 ossification GO:0001503 9.43 BMP7 SLC26A2
3 positive regulation of neuron differentiation GO:0045666 9.4 BMP7 GDF5
4 cartilage development GO:0051216 9.37 BMP7 GDF5
5 SMAD protein signal transduction GO:0060395 9.32 BMP7 GDF5
6 cell development GO:0048468 9.26 BMP7 GDF5
7 regulation of MAPK cascade GO:0043408 9.16 BMP7 GDF5
8 embryonic limb morphogenesis GO:0030326 8.96 BMP7 GDF5
9 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 8.62 BMP7 GDF5

Molecular functions related to Spondylolysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 8.62 BMP7 GDF5

Sources for Spondylolysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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