Aliases & Classifications for Spondylolysis

MalaCards integrated aliases for Spondylolysis:

Name: Spondylolysis 12 29 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2300
ICD10 33 M43.0 M43.00
MeSH 44 D013169
NCIt 50 C35034
UMLS 73 C0038018

Summaries for Spondylolysis

Disease Ontology : 12 A bone structure disease that involves a defect located in lumbar vertebral column.

MalaCards based summary : Spondylolysis is related to spondylolisthesis and scoliosis, and has symptoms including back pain An important gene associated with Spondylolysis is SLC26A2 (Solute Carrier Family 26 Member 2), and among its related pathways/superpathways are Glucose / Energy Metabolism and TGF-beta signaling pathway (KEGG). The drugs Teriparatide and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lumbar vertebral column.

Wikipedia : 76 Spondylolysis (spon-dee-low-lye-sis) is defined as a defect or stress fracture in the pars... more...

Related Diseases for Spondylolysis

Diseases related to Spondylolysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 spondylolisthesis 32.2 BMP7 FTH1 GDF5
2 scoliosis 10.4
3 neural tube defects 10.2
4 spina bifida occulta 10.2
5 brittle bone disorder 10.1
6 osteopetrosis 10.1
7 radiculopathy 10.1
8 osteoid osteoma 10.0
9 idiopathic scoliosis 10.0
10 syringomyelia 10.0
11 chiari malformation 10.0
12 proximal symphalangism 9.9 BMP7 GDF5
13 spondyloarthropathy 1 9.9
14 scoliosis, isolated 1 9.9
15 down syndrome 9.9
16 chiari malformation type ii 9.9
17 diastematomyelia 9.9
18 diastrophic dysplasia 9.9
19 pycnodysostosis 9.9
20 cerebral palsy 9.9
21 osteoarthritis 9.9
22 pseudoarthrosis 9.9
23 spinal stenosis 9.9
24 myelomeningocele 9.9
25 discitis 9.9
26 epidural abscess 9.9
27 spondylosis 9.9
28 aortic aneurysm 9.9
29 spondylitis 9.9
30 bone development disease 9.8 GDF5 SLC26A2
31 bone deterioration disease 9.8 BMP7 FTH1 GDF5
32 bone structure disease 9.8 BMP7 FTH1 GDF5

Graphical network of the top 20 diseases related to Spondylolysis:



Diseases related to Spondylolysis

Symptoms & Phenotypes for Spondylolysis

UMLS symptoms related to Spondylolysis:


back pain

Drugs & Therapeutics for Spondylolysis

Drugs for Spondylolysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
2
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
3
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
4
Pregabalin Approved, Illicit, Investigational Phase 4,Not Applicable 148553-50-8 5486971
5
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
6 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
7 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
8 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
9 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
10 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
11 Hormones Phase 4
12 Bone Density Conservation Agents Phase 4
13 Anesthetics, General Phase 4,Not Applicable
14 Anesthetics, Dissociative Phase 4
15 Excitatory Amino Acid Antagonists Phase 4
16 Narcotics Phase 4,Phase 3,Not Applicable
17 Anesthetics, Intravenous Phase 4
18 Excitatory Amino Acids Phase 4
19 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
20 Pharmaceutical Solutions Phase 4
21 Anesthetics, Local Phase 4,Phase 3,Phase 2
22 Psychotropic Drugs Phase 4
23 calcium channel blockers Phase 4
24 Anti-Anxiety Agents Phase 4
25 Tranquilizing Agents Phase 4
26 Calcium, Dietary Phase 4
27 Anticonvulsants Phase 4
28
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 113775-47-6 68602 5311068
29
Racepinephrine Approved Phase 3,Not Applicable 329-65-7 838
30
Morphine Approved, Investigational Phase 3,Not Applicable 57-27-2 5288826
31
Epinephrine Approved, Vet_approved Phase 3,Not Applicable 51-43-4 5816
32
Ropivacaine Approved Phase 3,Phase 2 84057-95-4 175805 71273
33 Analgesics, Non-Narcotic Phase 2, Phase 3
34 Adrenergic alpha-Agonists Phase 2, Phase 3,Phase 3
35 Adrenergic alpha-2 Receptor Agonists Phase 2, Phase 3
36 Adrenergic Agonists Phase 2, Phase 3,Phase 3
37 Hypnotics and Sedatives Phase 2, Phase 3
38 Adrenergic Agents Phase 2, Phase 3,Phase 3
39 Epinephryl borate Phase 3,Not Applicable
40 Anti-Asthmatic Agents Phase 3
41 Mydriatics Phase 3
42 Adrenergic beta-Agonists Phase 3
43 Bronchodilator Agents Phase 3
44 Respiratory System Agents Phase 3
45 Vasoconstrictor Agents Phase 3
46 Sympathomimetics Phase 3
47 Autonomic Agents Phase 3
48
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
49
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
50
Cisatracurium Approved Phase 2 96946-41-7

Interventional clinical trials:

(show top 50) (show all 135)
# Name Status NCT ID Phase Drugs
1 Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion Completed NCT01292252 Phase 4
2 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
3 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed NCT01325493 Phase 4 Ketamine;Normal Saline
4 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
5 A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
6 Effect of Pregabalin on Immediate Post-operative and Longterm Pain Recruiting NCT02464813 Phase 4 Pregabalin;Sugar pill;Oxycodone
7 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
8 BIO4 Clinical Case Study: Cervical Spine Active, not recruiting NCT03077204 Phase 4
9 Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion Not yet recruiting NCT03745040 Phase 4 Liposomal bupivacaine
10 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
11 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
12 Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion Unknown status NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo
13 Total Facet Arthroplasty System®(TFAS®) Clinical Trial Unknown status NCT00418197 Phase 3
14 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
15 Greenwich Lumbar Stenosis SLIP Study Completed NCT00109213 Phase 3
16 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
17 Peri-Incisional Drug Injection in Lumbar Spine Surgery Not yet recruiting NCT03513445 Phase 3 Morphine;Epinephrine;naropin
18 A Clinical Study of the Dynesys(R) Spinal System Terminated NCT00759057 Phase 3
19 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
20 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
21 Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion Completed NCT01106417 Phase 2
22 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy Completed NCT01097486 Phase 2
23 Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion Completed NCT00996073 Phase 2
24 Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF) Completed NCT00549913 Phase 1, Phase 2
25 Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis Recruiting NCT03100032 Phase 1, Phase 2
26 Transverse Abdominis Plane Block for Anterior Approach Spine Surgery Recruiting NCT02884440 Phase 2 TAP block ropivacaine;TAP block placebo;General anesthesia
27 Safety Study of Mesenchymal Stem Cells and Spinal Fusion Active, not recruiting NCT01552707 Phase 1, Phase 2
28 CopiOs Posterolateral Fusion Procedure Terminated NCT01123850 Phase 2
29 Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion Withdrawn NCT00810212 Phase 1, Phase 2
30 Supine vs. Upright Weight Bearing MRI in the Evaluation of Patients With Lumbar Spondylolisthesis Unknown status NCT02958241 Not Applicable
31 Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine Unknown status NCT01224379 Not Applicable
32 Post-market Surveillance Study of FLXfit™ TLIF Interbody Fusion Device Unknown status NCT02805985 Not Applicable
33 Post-market Study of the TOPS™ System Unknown status NCT02234154 Not Applicable
34 Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures Unknown status NCT02171169
35 Post-market Study of the TOPS™ System Unknown status NCT01933607 Not Applicable
36 InterFuse® S and T for the Treatment of Scoliosis, Spondylolisthesis and Degenerative Disc Disease (DDD) Unknown status NCT02659722
37 Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain Unknown status NCT01918943
38 Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression Unknown status NCT01338766 Not Applicable
39 Prospective Study of Minimally Invasive Spine Surgery Unknown status NCT01045473
40 Direct Repair Surgery for Spondylolysis of Lumbar in Young Population Completed NCT02129374 Not Applicable
41 The Addition of a Pilates Program for Short-Term Improvements in Patients With Spondylolysis or Spondylolisthesis Completed NCT01711203 Not Applicable
42 Feasibility of Using Functional Progression to Guide the Treatment of Adolescent Low Back Pain Completed NCT02861456 Not Applicable
43 Intra- And Inter-operator Reliability Of Isometric Back And Abdominal Muscle Strength Testing In Healthy Controls And Persons With Nonspecific Chronic Low Back Pain. Completed NCT03571880 Not Applicable
44 Retest-reliability and At-home-assessment Feasibility of the 5R-STS Completed NCT03321357
45 New Robotic Assistance System for Spinal Fusion Surgery Completed NCT02558621 Not Applicable
46 Prospective Clinical Evaluation of the New Aegis Plate for Anterior Interbody Fusions Completed NCT00555659
47 Effect of Addition of Dexmedetomidine During Ultrasound Guided Bilateral Single Shot Erector Spinae Plane Block in Patients Undergoing Posterior Lumbar Interbody Fusion Under General Anesthesia Completed NCT03746418 Early Phase 1 Ultrasound Guided Bilateral single shot Erector Spinae Plane Block
48 Free Hand Lumbar Pedicular Screw Fixation Completed NCT03327298 Not Applicable
49 Valeo OL Interbody Fusion Devices for Posterior Lumbar Interbody Fusion SNAP Trial Completed NCT01557829 Not Applicable
50 Multimodal Perioperative Pain Management Completed NCT01513564 Not Applicable Postoperative epidural morphine;Local anaesthesia

Search NIH Clinical Center for Spondylolysis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: spondylolysis

Genetic Tests for Spondylolysis

Genetic tests related to Spondylolysis:

# Genetic test Affiliating Genes
1 Spondylolysis 29

Anatomical Context for Spondylolysis

MalaCards organs/tissues related to Spondylolysis:

41
Bone, Testes

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolysis:

19
Lumbar Vertebral Column

Publications for Spondylolysis

Articles related to Spondylolysis:

(show top 50) (show all 603)
# Title Authors Year
1
Ultrashort Time-to-Echo Magnetic Resonance Imaging at 3 T for the Detection of Spondylolysis in Cadaveric Spines: Comparison With CT. ( 30157099 )
2019
2
Osteoid Osteoma Can Occur at the Pars Interarticularis of the Lumbar Spine, Leading to Misdiagnosis of Lumbar Spondylolysis. ( 29479057 )
2018
3
Efficacy and outcome predictors of fluoroscopy-guided facet joint injection for spondylolysis. ( 29396693 )
2018
4
Lumbar Hyperextension in Baseball Pitching: A Potential Cause of Spondylolysis. ( 29809066 )
2018
5
Spondylolysis and spondylolisthesis: A review of the literature. ( 29881164 )
2018
6
Biomechanical analysis of spino-pelvic postural configurations in spondylolysis subjected to various sport-related dynamic loading conditions. ( 29926211 )
2018
7
Mild (not severe) disc degeneration is implicated in the progression of bilateral L5 spondylolysis to spondylolisthesis. ( 29609581 )
2018
8
Multilevel Spondylolysis Repair Using the "Smiley Face" Technique with 3-Dimensional Intraoperative Spinal Navigation. ( 29054782 )
2018
9
High defect stage, contralateral defects, and poor flexibility are negative predictive factors of bone union in pediatric and adolescent athletes with spondylolysis. ( 29593182 )
2018
10
Predictive Factors for the Outcome of Surgical Treatment of Lumbar Spondylolysis in Young Sporting Individuals. ( 29662741 )
2018
11
A New Minimally Invasive Technique for Primary Unstable C2 Spondylolysis in an 8-Year-Old Child: A Case Report and Review of the Literature. ( 29654954 )
2018
12
Factors Associated with the Symptoms of Young Adults with L5 Spondylolysis. ( 29879775 )
2018
13
Diagnosis of Spondylolysis and Spondylolisthesis Is Delayed Six Months After Seeing Nonorthopedic Providers. ( 29735135 )
2018
14
A comparison of the techniques of direct pars interarticularis repairs for spondylolysis and low-grade spondylolisthesis: a meta-analysis. ( 29290131 )
2018
15
Return to Play in Adolescent Athletes With Symptomatic Spondylolysis Without Listhesis: A Meta-Analysis. ( 29662750 )
2018
16
Acquired spondylolysis and spinopelvic sagittal alignment. ( 29569131 )
2018
17
Double-level lumbar spondylolysis and spondylolisthesis: A retrospective study. ( 29548343 )
2018
18
Prevalence of curable and pseudoarthrosis stages of adolescent lumbar spondylolysis. ( 30546798 )
2018
19
The prevalence of lumbar spondylolysis in young children: a retrospective analysis using CT. ( 29030702 )
2018
20
Increased Lumbar Lordosis and Smaller Vertebral Cross-Sectional Area Are Associated With Spondylolysis. ( 29095410 )
2018
21
Imaging of Spondylolysis: The Evolving Role of Magnetic Resonance Imaging. ( 29428876 )
2018
22
Radiographic analysis of the listhesis associated with lumbar isthmic spondylolysis. ( 29807187 )
2018
23
Physical features of pediatric patients with lumbar spondylolysis and effectiveness of rehabilitation. ( 30282857 )
2018
24
Segmental Lordosis of the Spondylolytic Vertebrae in Adolescent Lumbar Spondylolysis: Differences between Bilateral L5 and L4 Spondylolysis. ( 30322253 )
2018
25
"Temporary " short segment fixation in treating Adolescent lumbar spondylolysis. ( 30448583 )
2018
26
Minimum of 10-year follow-up of V-rod technique in lumbar spondylolysis. ( 30478653 )
2018
27
Spondylolysis 2019 update. ( 30531225 )
2018
28
Relationship between individual payload weight and spondylolysis incidence in Turkish land forces. ( 30544316 )
2018
29
Headless compression screw in the neuronavigation-guided and microscope-assisted treatment of spondylolysis. ( 28988667 )
2017
30
Spondylolysis in the past: A case study of hunter-gatherers from Southern Patagonia. ( 29198391 )
2017
31
Different fusion approaches for single-level lumbar spondylolysis have similar perioperative outcomes. ( 28591074 )
2017
32
Vertebral body bone mineral density in patients with lumbar spondylolysis: a quantitative CT study. ( 28765098 )
2017
33
Active stretching for lower extremity muscle tightness in pediatric patients with lumbar spondylolysis. ( 28373610 )
2017
34
Adolescent Spondylolysis: Management and Return to Play. ( 28594517 )
2017
35
Congenital double-level cervical spondylolysis: a case report and review of the literature. ( 28247078 )
2017
36
Pediatric spondylolysis/spinal stenosis and disc herniation: national trends in decompression and discectomy surgery evaluated through the Kids' Inpatient Database. ( 28643037 )
2017
37
Contralateral Spondylolysis and Fracture of the Lumbar Pedicle in a Young Athlete. ( 28542108 )
2017
38
Spondylolisthesis with spondylolysis in a 17-month-old: a case report. ( 29354748 )
2017
39
Minimally-Invasive versus Conventional Repair of Spondylolysis in Athletes: A Review of Outcomes and Return to Play. ( 29093794 )
2017
40
Lumbar Back Pain Secondary to Spondylolysis. ( 28471908 )
2017
41
Current Evidence Regarding Diagnostic Imaging Methods for Pediatric Lumbar Spondylolysis: A Report From the Scoliosis Research Society Evidence-Based Medicine Committee. ( 28259272 )
2017
42
Does the Prevalence of Spondylolysis and Spina Bifida Occulta Observed in Pediatric Patients Remain Stable in Adults? ( 28937467 )
2017
43
Benign Natural History of Spondylolysis in Adolescence With Midterm Follow-Up. ( 28259265 )
2017
44
Lumbar Spondylolysis And Spondylolisthesis ( 28846329 )
2017
45
Low-Intensity Pulsed Ultrasound for Early-Stage Lumbar Spondylolysis in Young Athletes. ( 29035987 )
2017
46
Lumbar spondylolysis: A report of four cases from two generations of a family. ( 28617180 )
2017
47
Indirect pars repair for pediatric isthmic spondylolysis: a case series. ( 29057347 )
2017
48
The Relationship Between Sacral Slope and Symptomatic IsthmicA Spondylolysis in a Cohort of High School Athletes: A Retrospective Analysis. ( 28993288 )
2017
49
Prevalence of Spondylolysis in Symptomatic Adolescent Athletes: An Assessment of Sport Risk in Nonelite Athletes. ( 29140811 )
2017
50
Properties of Paraspinal Muscles in Japanese High School Baseball Players With Terminal-Stage Lumbar Spondylolysis. ( 28673735 )
2017

Variations for Spondylolysis

Expression for Spondylolysis

Search GEO for disease gene expression data for Spondylolysis.

Pathways for Spondylolysis

Pathways related to Spondylolysis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 FTH1 PGRMC1 SLC7A11
2 11.18 BMP7 GDF5
3
Show member pathways
11.02 BMP7 GDF5
4 10.23 FTH1 SLC7A11

GO Terms for Spondylolysis

Biological processes related to Spondylolysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.46 BMP7 SLC26A2
2 positive regulation of neuron differentiation GO:0045666 9.43 BMP7 GDF5
3 BMP signaling pathway GO:0030509 9.4 BMP7 GDF5
4 cartilage development GO:0051216 9.37 BMP7 GDF5
5 cell development GO:0048468 9.32 BMP7 GDF5
6 regulation of MAPK cascade GO:0043408 9.26 BMP7 GDF5
7 SMAD protein signal transduction GO:0060395 9.16 BMP7 GDF5
8 embryonic limb morphogenesis GO:0030326 8.96 BMP7 GDF5
9 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 8.62 BMP7 GDF5

Molecular functions related to Spondylolysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 8.62 BMP7 GDF5

Sources for Spondylolysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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