Spondylolysis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN029 MIFTS: 39	Spondylolysis Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Spondylolysis

MalaCards integrated aliases for Spondylolysis:

Name: Spondylolysis ¹² ²⁹ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the musculoskeletal system and connective tissue

Deforming dorsopathies

Other deforming dorsopathies

Spondylolysis

External Ids:

Disease Ontology ¹² DOID:2300

ICD10 ³³ M43.0 M43.00

MeSH ⁴⁴ D013169

NCIt ⁵⁰ C35034

UMLS ⁷³ C0038018

Sources

Summaries for Spondylolysis

Disease Ontology : ¹² A bone structure disease that involves a defect located in lumbar vertebral column.

MalaCards based summary : Spondylolysis is related to spondylolisthesis and scoliosis, and has symptoms including back pain An important gene associated with Spondylolysis is SLC26A2 (Solute Carrier Family 26 Member 2), and among its related pathways/superpathways are Glucose / Energy Metabolism and TGF-beta signaling pathway (KEGG). The drugs Teriparatide and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lumbar vertebral column.

Wikipedia : ⁷⁶ Spondylolysis (spon-dee-low-lye-sis) is defined as a defect or stress fracture in the pars... more...

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Related Diseases for Spondylolysis

Diseases related to Spondylolysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)

#	Related Disease	Score	Top Affiliating Genes
1	spondylolisthesis	32.2	BMP7 FTH1 GDF5
2	scoliosis	10.4
3	neural tube defects	10.2
4	spina bifida occulta	10.2
5	brittle bone disorder	10.1
6	osteopetrosis	10.1
7	radiculopathy	10.1
8	osteoid osteoma	10.0
9	idiopathic scoliosis	10.0
10	syringomyelia	10.0
11	chiari malformation	10.0
12	proximal symphalangism	9.9	BMP7 GDF5
13	spondyloarthropathy 1	9.9
14	scoliosis, isolated 1	9.9
15	down syndrome	9.9
16	chiari malformation type ii	9.9
17	diastematomyelia	9.9
18	diastrophic dysplasia	9.9
19	pycnodysostosis	9.9
20	cerebral palsy	9.9
21	osteoarthritis	9.9
22	pseudoarthrosis	9.9
23	spinal stenosis	9.9
24	myelomeningocele	9.9
25	discitis	9.9
26	epidural abscess	9.9
27	spondylosis	9.9
28	aortic aneurysm	9.9
29	spondylitis	9.9
30	bone development disease	9.8	GDF5 SLC26A2
31	bone deterioration disease	9.8	BMP7 FTH1 GDF5
32	bone structure disease	9.8	BMP7 FTH1 GDF5

Graphical network of the top 20 diseases related to Spondylolysis:

Sources

Symptoms & Phenotypes for Spondylolysis

UMLS symptoms related to Spondylolysis:

back pain

Sources

Drugs & Therapeutics for Spondylolysis

Drugs for Spondylolysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Teriparatide

Approved, Investigational

Phase 4

52232-67-4

16133850

Ketamine

Approved, Vet_approved

Phase 4,Phase 2

6740-88-1

3821

Bupivacaine

Approved, Investigational

Phase 4,Not Applicable

2180-92-9, 38396-39-3

2474

Pregabalin

Approved, Illicit, Investigational

Phase 4,Not Applicable

148553-50-8

5486971

Oxycodone

Approved, Illicit, Investigational

Phase 4

76-42-6

5284603

Central Nervous System Depressants

Phase 4,Phase 2,Phase 3,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 3,Not Applicable

Analgesics

Phase 4,Phase 2,Phase 3,Not Applicable

Anesthetics

Phase 4,Phase 2,Phase 3,Not Applicable

Neurotransmitter Agents

Phase 4,Phase 2,Phase 3

Hormones

Phase 4

Bone Density Conservation Agents

Phase 4

Anesthetics, General

Phase 4,Not Applicable

Anesthetics, Dissociative

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Narcotics

Phase 4,Phase 3,Not Applicable

Anesthetics, Intravenous

Phase 4

Excitatory Amino Acids

Phase 4

Analgesics, Opioid

Phase 4,Phase 3,Not Applicable

Pharmaceutical Solutions

Phase 4

Anesthetics, Local

Phase 4,Phase 3,Phase 2

Psychotropic Drugs

Phase 4

calcium channel blockers

Phase 4

Anti-Anxiety Agents

Phase 4

Tranquilizing Agents

Phase 4

Calcium, Dietary

Phase 4

Anticonvulsants

Phase 4

Dexmedetomidine

Approved, Vet_approved

Phase 2, Phase 3

113775-47-6

68602 5311068

Racepinephrine

Approved

Phase 3,Not Applicable

329-65-7

838

Morphine

Approved, Investigational

Phase 3,Not Applicable

57-27-2

5288826

Epinephrine

Approved, Vet_approved

Phase 3,Not Applicable

51-43-4

5816

Ropivacaine

Approved

Phase 3,Phase 2

84057-95-4

175805 71273

Analgesics, Non-Narcotic

Phase 2, Phase 3

Adrenergic alpha-Agonists

Phase 2, Phase 3,Phase 3

Adrenergic alpha-2 Receptor Agonists

Phase 2, Phase 3

Adrenergic Agonists

Phase 2, Phase 3,Phase 3

Hypnotics and Sedatives

Phase 2, Phase 3

Adrenergic Agents

Phase 2, Phase 3,Phase 3

Epinephryl borate

Phase 3,Not Applicable

Anti-Asthmatic Agents

Phase 3

Mydriatics

Phase 3

Adrenergic beta-Agonists

Phase 3

Bronchodilator Agents

Phase 3

Respiratory System Agents

Phase 3

Vasoconstrictor Agents

Phase 3

Sympathomimetics

Phase 3

Autonomic Agents

Phase 3

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2

1177-87-3

Propofol

Approved, Investigational, Vet_approved

Phase 2

2078-54-8

4943

Cisatracurium

Approved

Phase 2

96946-41-7

Interventional clinical trials:

(show top 50) (show all 135)

#	Name	Status	NCT ID	Phase	Drugs
1	Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion	Completed	NCT01292252	Phase 4
2	Spine Research With Roentgen Stereophotogrammetric Analysis	Completed	NCT00493558	Phase 4
3	Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia	Completed	NCT01325493	Phase 4	Ketamine;Normal Saline
4	Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis	Completed	NCT00000409	Phase 4
5	A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief	Recruiting	NCT03514277	Phase 4	Exparel;Bupivacaine
6	Effect of Pregabalin on Immediate Post-operative and Longterm Pain	Recruiting	NCT02464813	Phase 4	Pregabalin;Sugar pill;Oxycodone
7	Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis	Recruiting	NCT01921530	Phase 4
8	BIO4 Clinical Case Study: Cervical Spine	Active, not recruiting	NCT03077204	Phase 4
9	Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion	Not yet recruiting	NCT03745040	Phase 4	Liposomal bupivacaine
10	Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device	Terminated	NCT00095095	Phase 4
11	Efficacy of Using Solum IV and BMC With GFC in TLIF	Withdrawn	NCT03223701	Phase 4
12	Immune Effect of Dexmedetomidine in Patients Undergoing to Spinal Fusion	Unknown status	NCT02854904	Phase 2, Phase 3	Dexmedetomidine intervention;Placebo
13	Total Facet Arthroplasty System®(TFAS®) Clinical Trial	Unknown status	NCT00418197	Phase 3
14	Neurosurgery Patient Outcomes in Treating Spinal Disorders	Completed	NCT01220921	Phase 3
15	Greenwich Lumbar Stenosis SLIP Study	Completed	NCT00109213	Phase 3
16	Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis	Completed	NCT00405691	Phase 3
17	Peri-Incisional Drug Injection in Lumbar Spine Surgery	Not yet recruiting	NCT03513445	Phase 3	Morphine;Epinephrine;naropin
18	A Clinical Study of the Dynesys(R) Spinal System	Terminated	NCT00759057	Phase 3
19	Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery	Unknown status	NCT00798902	Phase 1, Phase 2
20	Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery	Unknown status	NCT00798239	Phase 1, Phase 2
21	Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion	Completed	NCT01106417	Phase 2
22	Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy	Completed	NCT01097486	Phase 2
23	Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion	Completed	NCT00996073	Phase 2
24	Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF)	Completed	NCT00549913	Phase 1, Phase 2
25	Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis	Recruiting	NCT03100032	Phase 1, Phase 2
26	Transverse Abdominis Plane Block for Anterior Approach Spine Surgery	Recruiting	NCT02884440	Phase 2	TAP block ropivacaine;TAP block placebo;General anesthesia
27	Safety Study of Mesenchymal Stem Cells and Spinal Fusion	Active, not recruiting	NCT01552707	Phase 1, Phase 2
28	CopiOs Posterolateral Fusion Procedure	Terminated	NCT01123850	Phase 2
29	Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion	Withdrawn	NCT00810212	Phase 1, Phase 2
30	Supine vs. Upright Weight Bearing MRI in the Evaluation of Patients With Lumbar Spondylolisthesis	Unknown status	NCT02958241	Not Applicable
31	Comparison of Standard Fusion With "Topping Off"-System in Lumbar Spine	Unknown status	NCT01224379	Not Applicable
32	Post-market Surveillance Study of FLXfit™ TLIF Interbody Fusion Device	Unknown status	NCT02805985	Not Applicable
33	Post-market Study of the TOPS™ System	Unknown status	NCT02234154	Not Applicable
34	Retrospective, Multicenter Clinical Evaluation of Health Economic Drivers and Complications for Two Lumbar Fusion Procedures	Unknown status	NCT02171169
35	Post-market Study of the TOPS™ System	Unknown status	NCT01933607	Not Applicable
36	InterFuse® S and T for the Treatment of Scoliosis, Spondylolisthesis and Degenerative Disc Disease (DDD)	Unknown status	NCT02659722
37	Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain	Unknown status	NCT01918943
38	Spondylolisthesis Treated With an iO-Flex® System Enabled Decompression	Unknown status	NCT01338766	Not Applicable
39	Prospective Study of Minimally Invasive Spine Surgery	Unknown status	NCT01045473
40	Direct Repair Surgery for Spondylolysis of Lumbar in Young Population	Completed	NCT02129374	Not Applicable
41	The Addition of a Pilates Program for Short-Term Improvements in Patients With Spondylolysis or Spondylolisthesis	Completed	NCT01711203	Not Applicable
42	Feasibility of Using Functional Progression to Guide the Treatment of Adolescent Low Back Pain	Completed	NCT02861456	Not Applicable
43	Intra- And Inter-operator Reliability Of Isometric Back And Abdominal Muscle Strength Testing In Healthy Controls And Persons With Nonspecific Chronic Low Back Pain.	Completed	NCT03571880	Not Applicable
44	Retest-reliability and At-home-assessment Feasibility of the 5R-STS	Completed	NCT03321357
45	New Robotic Assistance System for Spinal Fusion Surgery	Completed	NCT02558621	Not Applicable
46	Prospective Clinical Evaluation of the New Aegis Plate for Anterior Interbody Fusions	Completed	NCT00555659
47	Effect of Addition of Dexmedetomidine During Ultrasound Guided Bilateral Single Shot Erector Spinae Plane Block in Patients Undergoing Posterior Lumbar Interbody Fusion Under General Anesthesia	Completed	NCT03746418	Early Phase 1	Ultrasound Guided Bilateral single shot Erector Spinae Plane Block
48	Free Hand Lumbar Pedicular Screw Fixation	Completed	NCT03327298	Not Applicable
49	Valeo OL Interbody Fusion Devices for Posterior Lumbar Interbody Fusion SNAP Trial	Completed	NCT01557829	Not Applicable
50	Multimodal Perioperative Pain Management	Completed	NCT01513564	Not Applicable	Postoperative epidural morphine;Local anaesthesia

Search NIH Clinical Center for Spondylolysis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

baclofen

Cochrane evidence based reviews: spondylolysis

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Genetic Tests for Spondylolysis

Genetic tests related to Spondylolysis:

#	Genetic test	Affiliating Genes
1	Spondylolysis ²⁹

Sources

Anatomical Context for Spondylolysis

MalaCards organs/tissues related to Spondylolysis:

⁴¹

Bone, Testes

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolysis:

¹⁹

Lumbar Vertebral Column

Sources

Publications for Spondylolysis

Articles related to Spondylolysis:

(show top 50) (show all 603)

#	Title	Authors	Year
1	Ultrashort Time-to-Echo Magnetic Resonance Imaging at 3 T for the Detection of Spondylolysis in Cadaveric Spines: Comparison With CT. ( 30157099 )	Finkenstaedt T...Bae WC	2019
2	Osteoid Osteoma Can Occur at the Pars Interarticularis of the Lumbar Spine, Leading to Misdiagnosis of Lumbar Spondylolysis. ( 29479057 )	Ono T....Shimizu A.	2018
3	Efficacy and outcome predictors of fluoroscopy-guided facet joint injection for spondylolysis. ( 29396693 )	Kang W.Y....Kang H.S.	2018
4	Lumbar Hyperextension in Baseball Pitching: A Potential Cause of Spondylolysis. ( 29809066 )	Singh H....Nissen C.	2018
5	Spondylolysis and spondylolisthesis: A review of the literature. ( 29881164 )	Gagnet P....Ebraheim N.	2018
6	Biomechanical analysis of spino-pelvic postural configurations in spondylolysis subjected to various sport-related dynamic loading conditions. ( 29926211 )	Sterba M....Aubin C.A.8.	2018
7	Mild (not severe) disc degeneration is implicated in the progression of bilateral L5 spondylolysis to spondylolisthesis. ( 29609581 )	Ramakrishna V.A.S....Diwan A.D.	2018
8	Multilevel Spondylolysis Repair Using the &quot;Smiley Face&quot; Technique with 3-Dimensional Intraoperative Spinal Navigation. ( 29054782 )	Voisin M.R....Yang V.	2018
9	High defect stage, contralateral defects, and poor flexibility are negative predictive factors of bone union in pediatric and adolescent athletes with spondylolysis. ( 29593182 )	Yamazaki K....Suzuki Y.	2018
10	Predictive Factors for the Outcome of Surgical Treatment of Lumbar Spondylolysis in Young Sporting Individuals. ( 29662741 )	Debnath U.K....McConnell J.R.	2018
11	A New Minimally Invasive Technique for Primary Unstable C2 Spondylolysis in an 8-Year-Old Child: A Case Report and Review of the Literature. ( 29654954 )	Farah K....Fuentes S.	2018
12	Factors Associated with the Symptoms of Young Adults with L5 Spondylolysis. ( 29879775 )	Kim M.W....Lee S.	2018
13	Diagnosis of Spondylolysis and Spondylolisthesis Is Delayed Six Months After Seeing Nonorthopedic Providers. ( 29735135 )		2018
14	A comparison of the techniques of direct pars interarticularis repairs for spondylolysis and low-grade spondylolisthesis: a meta-analysis. ( 29290131 )		2018
15	Return to Play in Adolescent Athletes With Symptomatic Spondylolysis Without Listhesis: A Meta-Analysis. ( 29662750 )		2018
16	Acquired spondylolysis and spinopelvic sagittal alignment. ( 29569131 )		2018
17	Double-level lumbar spondylolysis and spondylolisthesis: A retrospective study. ( 29548343 )		2018
18	Prevalence of curable and pseudoarthrosis stages of adolescent lumbar spondylolysis. ( 30546798 )	Tatsumura M...Hirano A	2018
19	The prevalence of lumbar spondylolysis in young children: a retrospective analysis using CT. ( 29030702 )	Lemoine T...Morel B	2018
20	Increased Lumbar Lordosis and Smaller Vertebral Cross-Sectional Area Are Associated With Spondylolysis. ( 29095410 )	Wren TAL...Gilsanz V	2018
21	Imaging of Spondylolysis: The Evolving Role of Magnetic Resonance Imaging. ( 29428876 )	Mushtaq R...Guzm?n P?rez-Carrillo GJ	2018
22	Radiographic analysis of the listhesis associated with lumbar isthmic spondylolysis. ( 29807187 )	Legaye J	2018
23	Physical features of pediatric patients with lumbar spondylolysis and effectiveness of rehabilitation. ( 30282857 )	Iwaki K...Tsuji S	2018
24	Segmental Lordosis of the Spondylolytic Vertebrae in Adolescent Lumbar Spondylolysis: Differences between Bilateral L5 and L4 Spondylolysis. ( 30322253 )	Sugawara K...Katayose M	2018
25	"Temporary " short segment fixation in treating Adolescent lumbar spondylolysis. ( 30448583 )	Hang Y...Du J	2018
26	Minimum of 10-year follow-up of V-rod technique in lumbar spondylolysis. ( 30478653 )	Linhares D...Neves N	2018
27	Spondylolysis 2019 update. ( 30531225 )	Berger RG...Doyle SM	2018
28	Relationship between individual payload weight and spondylolysis incidence in Turkish land forces. ( 30544316 )		2018
29	Headless compression screw in the neuronavigation-guided and microscope-assisted treatment of spondylolysis. ( 28988667 )	Goncalves-RamA-rez F.J....Manuel-Rimbau J.	2017
30	Spondylolysis in the past: A case study of hunter-gatherers from Southern Patagonia. ( 29198391 )	D'Angelo Del Campo M.D....GuichA^n R.A.	2017
31	Different fusion approaches for single-level lumbar spondylolysis have similar perioperative outcomes. ( 28591074 )	Gala R.J....Grauer J.N.	2017
32	Vertebral body bone mineral density in patients with lumbar spondylolysis: a quantitative CT study. ( 28765098 )	Gezer N.S....Ur K.	2017
33	Active stretching for lower extremity muscle tightness in pediatric patients with lumbar spondylolysis. ( 28373610 )	Sato M....Sairyo K.	2017
34	Adolescent Spondylolysis: Management and Return to Play. ( 28594517 )	Warner W.C....de MendonAsa R.G.M.	2017
35	Congenital double-level cervical spondylolysis: a case report and review of the literature. ( 28247078 )	Yamamoto N....Ozaki T.	2017
36	Pediatric spondylolysis/spinal stenosis and disc herniation: national trends in decompression and discectomy surgery evaluated through the Kids' Inpatient Database. ( 28643037 )	Huynh T.R....Drazin D.	2017
37	Contralateral Spondylolysis and Fracture of the Lumbar Pedicle in a Young Athlete. ( 28542108 )	Kessous E....d'Hemecourt P.A.	2017
38	Spondylolisthesis with spondylolysis in a 17-month-old: a case report. ( 29354748 )	O'Donnell M....Sun M.H.	2017
39	Minimally-Invasive versus Conventional Repair of Spondylolysis in Athletes: A Review of Outcomes and Return to Play. ( 29093794 )	Kolcun J.P.G....Wang M.Y.	2017
40	Lumbar Back Pain Secondary to Spondylolysis. ( 28471908 )	Rothenberg Maddocks A.B....Pollock A.N.	2017
41	Current Evidence Regarding Diagnostic Imaging Methods for Pediatric Lumbar Spondylolysis: A Report From the Scoliosis Research Society Evidence-Based Medicine Committee. ( 28259272 )	Ledonio C.G....Sanders J.O.	2017
42	Does the Prevalence of Spondylolysis and Spina Bifida Occulta Observed in Pediatric Patients Remain Stable in Adults? ( 28937467 )	Urrutia J....Cuellar J.	2017
43	Benign Natural History of Spondylolysis in Adolescence With Midterm Follow-Up. ( 28259265 )	Sousa T....Andras L.M.	2017
44	Lumbar Spondylolysis And Spondylolisthesis ( 28846329 )	Donnally III C.J....Dulebohn S.C.	2017
45	Low-Intensity Pulsed Ultrasound for Early-Stage Lumbar Spondylolysis in Young Athletes. ( 29035987 )	Tsukada M....Watanabe K.	2017
46	Lumbar spondylolysis: A report of four cases from two generations of a family. ( 28617180 )		2017
47	Indirect pars repair for pediatric isthmic spondylolysis: a case series. ( 29057347 )		2017
48	The Relationship Between Sacral Slope and Symptomatic IsthmicA Spondylolysis in a Cohort of High School Athletes: A Retrospective Analysis. ( 28993288 )		2017
49	Prevalence of Spondylolysis in Symptomatic Adolescent Athletes: An Assessment of Sport Risk in Nonelite Athletes. ( 29140811 )		2017
50	Properties of Paraspinal Muscles in Japanese High School Baseball Players With Terminal-Stage Lumbar Spondylolysis. ( 28673735 )		2017

Sources

Genes for Spondylolysis

Genes related to Spondylolysis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SLC26A2	Solute Carrier Family 26 Member 2	Protein Coding	21.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	BMP7	Bone Morphogenetic Protein 7	Protein Coding	18.65	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	17669279
3	FTH1	Ferritin Heavy Chain 1	Protein Coding	16.06	DISEASES inferred ¹⁵
4	GDF5	Growth Differentiation Factor 5	Protein Coding	15.39	DISEASES inferred ¹⁵
5	FUS	FUS RNA Binding Protein	Protein Coding	15.28	DISEASES inferred ¹⁵
6	SLC7A11	Solute Carrier Family 7 Member 11	Protein Coding	15.05	DISEASES inferred ¹⁵
7	PGRMC1	Progesterone Receptor Membrane Component 1	Protein Coding	14.97	DISEASES inferred ¹⁵

Sources

Variations for Spondylolysis

Sources

Expression for Spondylolysis

Search GEO for disease gene expression data for Spondylolysis.

Sources

Pathways for Spondylolysis

Pathways related to Spondylolysis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glucose / Energy Metabolism ⁴	11.62	FTH1 PGRMC1 SLC7A11
2	TGF-beta signaling pathway (KEGG) ³⁷	11.18	BMP7 GDF5
3	Elastic fibre formation ⁶⁶ Show member pathways Molecules associated with elastic fibres ⁶⁶	11.02	BMP7 GDF5
4	Ferroptosis ³⁷	10.23	FTH1 SLC7A11

Sources

GO Terms for Spondylolysis

Biological processes related to Spondylolysis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ossification	GO:0001503	9.46	BMP7 SLC26A2
2	positive regulation of neuron differentiation	GO:0045666	9.43	BMP7 GDF5
3	BMP signaling pathway	GO:0030509	9.4	BMP7 GDF5
4	cartilage development	GO:0051216	9.37	BMP7 GDF5
5	cell development	GO:0048468	9.32	BMP7 GDF5
6	regulation of MAPK cascade	GO:0043408	9.26	BMP7 GDF5
7	SMAD protein signal transduction	GO:0060395	9.16	BMP7 GDF5
8	embryonic limb morphogenesis	GO:0030326	8.96	BMP7 GDF5
9	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:0010862	8.62	BMP7 GDF5

Molecular functions related to Spondylolysis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transforming growth factor beta receptor binding	GO:0005160	8.62	BMP7 GDF5

Sources

Sources for Spondylolysis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Spondylolysis

Aliases & Classifications for Spondylolysis

MalaCards integrated aliases for Spondylolysis:

Classifications:

External Ids:

Summaries for Spondylolysis

Related Diseases for Spondylolysis

Diseases related to Spondylolysis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Spondylolysis:

Symptoms & Phenotypes for Spondylolysis

UMLS symptoms related to Spondylolysis:

Drugs & Therapeutics for Spondylolysis

Drugs for Spondylolysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: spondylolysis

Genetic Tests for Spondylolysis

Genetic tests related to Spondylolysis:

Anatomical Context for Spondylolysis

MalaCards organs/tissues related to Spondylolysis:

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylolysis:

Publications for Spondylolysis

Articles related to Spondylolysis:

Genes for Spondylolysis

Genes related to Spondylolysis (0 elite genes):

Variations for Spondylolysis

Expression for Spondylolysis

Pathways for Spondylolysis

Pathways related to Spondylolysis according to GeneCards Suite gene sharing:

GO Terms for Spondylolysis

Biological processes related to Spondylolysis according to GeneCards Suite gene sharing:

Molecular functions related to Spondylolysis according to GeneCards Suite gene sharing:

Sources for Spondylolysis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :