Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Spondylosis

MalaCards integrated aliases for Spondylosis:

Name: Spondylosis 12 44 15 70 32
Spondylogenic Compression of Thoracic Spinal Cord 12
Spondylogenic Compression of Lumbar Spinal Cord 12
Thoracic or Lumbar Spondylosis with Myelopathy 12
Lumbosacral Spondylosis Without Myelopathy 12
Lumbar Spondylosis with Myelopathy 12
Spondylosis with Myelopathy 12


External Ids:

Disease Ontology 12 DOID:2247
ICD9CM 34 721.9
MeSH 44 D055009
SNOMED-CT 67 8847002
ICD10 32 M47 M47.9
UMLS 70 C0038019

Summaries for Spondylosis

Disease Ontology : 12 An bone structure disease that involves degeneration between vertebra located in vertebral column.

MalaCards based summary : Spondylosis, also known as spondylogenic compression of thoracic spinal cord, is related to radiculopathy and degenerative disc disease. An important gene associated with Spondylosis is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Pregabalin and Teriparatide have been mentioned in the context of this disorder. Affiliated tissues include vertebral column, spinal cord and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 Spondylosis is the degeneration of the vertebral column from any cause. In the more narrow sense it... more...

Related Diseases for Spondylosis

Diseases related to Spondylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)
# Related Disease Score Top Affiliating Genes
1 radiculopathy 31.0 LAPTM4A BMP2 ACAN
2 degenerative disc disease 30.7 VDR BMP2 ACAN
3 spondylolysis 30.4 BMP2 ACAN
4 spondylolisthesis 30.2 PTH ESR1 CRP BMP2 ACAN
5 head injury 30.0 S100B ENO2
6 cauda equina syndrome 30.0 CRP BMP2
7 arachnoiditis 29.7 IL1B CRP
8 bone cancer 29.7 VDR PTH ESR1 BMP2
9 discitis 29.6 CRP ACAN
10 chondromalacia 29.6 CRP ACAN
11 lymphadenitis 29.6 VDR IL1B CRP
12 dysentery 29.6 IL1B ENO2 CRP
13 encephalomalacia 29.6 S100B IL1B CRP
14 lyme disease 29.6 IL1B ENO2 CRP
15 arthropathy 29.5 IL1B CRP ACAN
16 osteomyelitis 29.5 IL1B CRP BMP2
17 synovitis 29.3 IL1B CRP ACAN
18 enthesopathy 29.3 PTH LAPTM4A KL CRP ACAN
19 bone disease 29.2 VDR PTH IL1B ESR1 BMP2 ACAN
20 nerve compression syndrome 29.2 PTH LIPN CRP
21 osteoporosis 29.1 WRN VDR PTH KL IL1B HMGCR
22 migraine with or without aura 1 28.3 S100B LIPN LAPTM4A IL1B ESR1 CRP
23 spondylosis, cervical 11.5
24 cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 11.2
25 central cord syndrome 11.0
26 barre-lieou syndrome 10.9
27 spastic paraplegia 25 10.9
28 dysphagia 10.5
29 exostosis 10.4
30 protrusio acetabuli 10.4 VDR ESR1
31 back pain 10.4
32 vulvar vestibulitis syndrome 10.4 IL1B ESR1
33 pediatric ovarian germ cell tumor 10.4 PTH ENO2
34 ossification of the posterior longitudinal ligament of spine 10.4
35 pediatric ovarian dysgerminoma 10.4 PTH ENO2
36 spinal stenosis 10.4
37 intracranial cysts 10.3 S100B ENO2
38 tracheal calcification 10.3 PTH KL
39 bednar tumor 10.3 S100B ENO2
40 meningeal melanocytoma 10.3 S100B ENO2
41 nephrolithiasis/osteoporosis, hypophosphatemic, 1 10.3 PTH KL
42 hyperostosis 10.3
43 pineocytoma 10.3 S100B ENO2
44 campylobacteriosis 10.3 VDR IL1B HTRA1
45 osteoarthritis 10.3
46 hypervitaminosis d 10.3 VDR PTH KL
47 phosphorus metabolism disease 10.3 VDR PTH KL
48 parathyroid gland disease 10.3 VDR PTH KL
49 hypercalcemia, infantile, 1 10.3 VDR PTH
50 inflammatory spondylopathy 10.3

Comorbidity relations with Spondylosis via Phenotypic Disease Network (PDN):

Acute Cystitis

Graphical network of the top 20 diseases related to Spondylosis:

Diseases related to Spondylosis

Symptoms & Phenotypes for Spondylosis

MGI Mouse Phenotypes related to Spondylosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 BMP2 CRP ESR1 HTRA1 IL1B KL
2 homeostasis/metabolism MP:0005376 9.97 BMP2 CRP ESR1 HELLS HMGCR IL1B
3 craniofacial MP:0005382 9.8 BMP2 ENO2 IL1B KL PTH VDR
4 limbs/digits/tail MP:0005371 9.61 BMP2 ESR1 HELLS KL LAPTM4A MKX
5 skeleton MP:0005390 9.36 BMP2 ESR1 HELLS HTRA1 IL1B KL

Drugs & Therapeutics for Spondylosis

Drugs for Spondylosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4 445354
9 Anticonvulsants Phase 4
10 Calcium, Dietary Phase 4
11 calcium channel blockers Phase 4
12 retinol Phase 4
13 Retinol palmitate Phase 4
14 Dexamethasone 21-phosphate Phase 4
protease inhibitors Phase 4
16 HIV Protease Inhibitors Phase 4
17 Triamcinolone diacetate Phase 4
18 Triamcinolone hexacetonide Phase 4
19 Immunosuppressive Agents Phase 4
20 Immunologic Factors Phase 4
21 triamcinolone acetonide Phase 4
22 BB 1101 Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Ibuprofen Approved Phase 2 15687-27-1 3672
25 Analgesics Phase 2
26 Analgesics, Non-Narcotic Phase 2
27 Narcotics Phase 2
28 Analgesics, Opioid Phase 2
29 Antirheumatic Agents Phase 2
30 Cyclooxygenase Inhibitors Phase 2
31 Anti-Inflammatory Agents, Non-Steroidal Phase 2
Meloxicam Approved, Vet_approved 71125-38-7 5281106 54677470
Dexmedetomidine Approved, Vet_approved 113775-47-6 5311068 68602
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
Isoflurane Approved, Vet_approved 26675-46-7 3763
Etoricoxib Approved, Investigational 202409-33-4 123619
tannic acid Approved 1401-55-4
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
Peppermint Approved
Midazolam Approved, Illicit 59467-70-8 4192
Acetaminophen Approved 103-90-2 1983
Ketorolac Approved 74103-06-3, 66635-83-4 3826
43 Adrenergic alpha-Agonists
44 Adrenergic Agents
45 Adrenergic Agonists
46 Antihypertensive Agents
47 Anesthetics, Local
48 Anesthetics, Inhalation
49 Cyclooxygenase 2 Inhibitors
50 Psychotropic Drugs

Interventional clinical trials:

(show top 50) (show all 78)
# Name Status NCT ID Phase Drugs
1 Open Labelled Study of Pregabalin in the Treatment of Neuropathic Pain in Cervical Myeloradiculopathy (Pregabalin and Radicular Pain Study (PARPS)) Completed NCT01061697 Phase 4 Pregabalin
2 Assessment of the Efficacy of Forteo (Teriparatide) in Patients Undergoing Posterolateral Lumbar Spinal Fusion Completed NCT01292252 Phase 4
3 The Effectiveness of Cervical Transforaminal Epidural Steroid Injection for the Treatment of Cervical Radicular Pain: A Prospective Cohort Study. Recruiting NCT04544683 Phase 4 Cervical Transforaminal Epidural Injection with dexamethasone sodium phosphate
4 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
5 Randomized Prospective Study of Particulate Corticosteroid Versus Non-particulate Corticosteroid for Sacroiliac Joint Steroid Injection Enrolling by invitation NCT03166761 Phase 4 Dexamethasone;Triamcinolone Acetonide
6 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Withdrawn NCT03327272 Phase 3 Methylprednisolone;Saline
7 Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery Terminated NCT02276911 Phase 2 Ibuprofen
8 Predictors of Outcome and Natural History in Patients With Cervical Spondylotic Myelopathy Unknown status NCT02936245
9 Balance Chiropractic Therapy for Cervical Spondylotic Radiculopathy: a Randomized Parallel-controlled Trial Unknown status NCT02705131
10 Evaluation on Efficacy of Total Artificial Disc Replacement (TDR) of Cervical Spondylosis: a Cohort Prospective Follow-up for 5 Years Unknown status NCT03364816
11 A Muti-Center Study Comparing 3 Procedures for Bi-level Cervical Spondylosis Unknown status NCT03358225
12 Study on the Early Warning and Treatment of Cervical Spondylosis of Cervical Type on Young People Based on the " Move Generate Yang " Theory Unknown status NCT02199405
13 Recovery Profiles After c Spine Surgery: With or Without Dexmedetomidine as an Anesthetic Adjuvant Unknown status NCT02819089 Dexmedetomidine
14 Evaluation of Safety and Efficency of Custom-made Corpectomy Implants: UNiD 3D VBR Unknown status NCT02926391
15 Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain in the Presence of Lumbar Instability and Degenerative Disk Disease Unknown status NCT01918943
16 A Prospective Study Using Actifuse SHAPE Versus Autograft With Demineralized Bone Matrix to Achieve Bone Fusion in Anterior Cervical Corpectomy (ACC) Unknown status NCT02005081
17 Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study Unknown status NCT02873182
18 Diffusion Tensor Imaging of the Brain and Cervical Spine: Evaluation of Reproducibility in Normal Subjects and Diagnostic Utility in Patients With Cervical Spondylotic Myelopathy Completed NCT01868958
19 Yoga Chikitsa for Neck Pain Caused by Cervical Spondylosis: a Randomized Controlled Pilot Trial Completed NCT03526965 Usual care
20 Structural Spinal Cord Integrity in Patients With Cervical Spondylosis in Relation to Clinical Status Completed NCT01243684
21 Decompressive Cervical Surgery for Antihypertensive Effect in Patients With Cervical Spondylosis and Hypertension-A Cohort Study Completed NCT02016768
22 Comparison Between the Segmental Mobilization and Entire Segmental Spine Mobilization in Cervical Spondylosis Completed NCT04287634
23 Comparison Between Segmental Mobilization And Entire Spine Mobilization In Lumbar Spondylosis Completed NCT04158115
24 Effectiveness of Yoga Therapy for Neck Pain Relief in Patients With Cervical Spondylosis Completed NCT04113473
25 Change of Lumbar Symptom After Surgical Treatment for Patients With Cervical Stenosis Completed NCT03089931
26 The Effect of Medial Branch Radiofrequency Ablation on Functional Spinal Stability and Lumbar Multifidi Muscle Architecture Assessed by Magnetic Resonance Imaging and Ultrasound Imaging Completed NCT03744260
27 Ultrasound Versus Fluoroscopic Guided Sacroiliac Joint Injection In Patients With Chronic Sacroiliac Joint Pain Completed NCT04446988
28 Allograft Alone Versus Allograft With Bone Marrow Concentrate for the Healing of the Instrumented Posterolateral Lumbar Fusion Completed NCT01603836
29 Does Inhalational Anesthesia Accelerate Postoperative Cognitive Decline? Completed NCT00788008 inhalation anesthesia with isoflurane vs. TIVA with propofol
30 Prospective, Multi-center, Cohort Study of the Cost Effectiveness of Osteopathic Manipulative Treatment for Chronic Low Back Pain Completed NCT03532230
31 Efficacy and Safety of OsteoStrux™ Collagen Ceramic Scaffold in Instrumented Lumbar Spine Fusion Completed NCT01873586
32 Efficacy and Safety of Integra Accell Evo3 Demineralized Bone Matrix Instrumented Posterolateral Lumbar Spine Fusion Completed NCT01430299
33 The Efficacy/Safety Profile Of Pulsed Shortwave Therapy in Cervical Osteoarthritis: A Comparison Study Against Etoricoxib Completed NCT03542955 Etoricoxib 60 mg
34 Prospective Clinical Evaluation of the New Aegis Plate for Anterior Interbody Completed NCT00555659
35 Clinical Trial on Performance and Acceptance of a New Robotic Assistance System During Spinal Fusion Surgery Completed NCT02558621
36 Efficacy and Safety of Integra Accell Evo3 Demineralized Bone Matrix in Instrumented Lumbar Spine Fusion Completed NCT01714804
37 Accell Evo3™ Demineralized Bone Matrix in Instrumented Lumbar Spine Fusion Completed NCT02018445
38 Prospective Follow-up Study of the Aesculap Quintex® Anterior Cervical Plating System After a Minimum of One Year Completed NCT04489394
39 High-Resolution Diffusion Tensor Imaging (DTI) of the Cervical Spinal Cord in the Setting of Spinal Cord Injury (SCI) Completed NCT01407705
40 A Prospective Study Comparison of Clinical Outcome After Different Rate Infusion in Caudal Epidural Steroid Injection Completed NCT02939482 Triamcinolone Acetonide and normal saline solution
41 Test-retest-reliability and At-home-assessment Feasibility of the Five-repetition Sit-to-stand Test (5R-STS) Completed NCT03321357
42 Back in the Game: A Pilot Study Assessing an Immediate Functional Progression Program in Athletes With a Spondylolysis. Completed NCT03237104
43 NuTech NuCel®: A Prospective, Efficacy Study of NuCel® in Patients Undergoing Fusion for One, Two or Three Level Degenerative Disease of the Lumbar Spine. Completed NCT02023372
44 Short-Term Effects of Kinesio Taping® on Pain and Functionality in Patients With Cervical Spine Surgery Completed NCT04039581
45 Predictive Value of Diffusion MRI in Cervical Spondylotic Myelopathy Recruiting NCT03296592
46 A Randomised Controlled Trial Comparing the Effectiveness of Surgical and Nonsurgical Treatment for Cervical Radiculopathy Recruiting NCT03674619
47 Effects of Extension Oriented Treatment Approach (EOTA) With Or Without Mechanical Traction For Patients With Lumbar Spondylosis Recruiting NCT04747483
48 Comparison of the Effects of Muscle Energy Technique and Mobilization Techniques on Cervical Proprioception and Motor Control in Patients With Cervical Spondylosis: A Randomized Controlled Study Recruiting NCT04777318
49 Return of Bowel Function After One or Two Level Anterior Lumbar Interbody Fusion With Chewing Gum Recruiting NCT03945461
50 A Prospective Study Investigating the Effect of Midazolam Sedation on Diagnostic Lumbar Medial Branch Blocks Recruiting NCT04453449 Midazolam

Search NIH Clinical Center for Spondylosis

Cochrane evidence based reviews: spondylosis

Genetic Tests for Spondylosis

Anatomical Context for Spondylosis

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylosis:

Vertebral Column

MalaCards organs/tissues related to Spondylosis:

Spinal Cord, Bone, Bone Marrow, Brain, Cortex, Skin, Heart

Publications for Spondylosis

Articles related to Spondylosis:

(show top 50) (show all 3371)
# Title Authors PMID Year
"Hand as foot" teaching method in neurogenic cervical spondylosis and lumbar disc herniation. 61
33579608 2021
Impact of Preoperative Opioid Use on Postoperative Patient-reported Outcomes in Lumbar Spine Surgery Patients. 61
32960822 2021
Detection of cerebral reorganization associated with degenerative cervical myelopathy using diffusion spectral imaging (DSI). 61
33775321 2021
Impact of Sarcopenia on Degenerative Lumbar Spondylosis. 61
33633055 2021
Lumbar Bracing for Chronic Low Back Pain: A Randomized Controlled Trial. 61
33789322 2021
Fusion and Subsidence Rates of Vertebral Body Sliding Osteotomy: Comparison of 3 Reconstructive Techniques for Multilevel Cervical Myelopathy. 61
33774212 2021
Sagittal Alignment in Patients with Thoracic Myelopathy Caused by the Ossification of the Ligamentum Flavum: A Retrospective Matched Case-Control Study. 61
33534440 2021
Anterior Cervical Discectomy and Fusion: A Surgical Intervention for Treating Cervical Disc Disease. 61
33646576 2021
Four-level Anterior Cervical Discectomy and Fusions: Results Following Multilevel Cervical Fusion With a Minimum 1-Year Follow-up. 61
33769972 2021
Results of Four-Level Anterior Cervical Discectomy and Fusion Using Stand-Alone Interbody Titanium Cages. 61
33687861 2021
Effect of Baduanjin exercise on cervical spondylosis: A protocol for the systematic review of randomized controlled trials. 61
33761641 2021
A population-based case-control study of the association between cervical spondylosis and tinnitus. 61
32930015 2021
Comparison of the surgeries for the ossification of the posterior longitudinal ligament-related cervical spondylosis: A PRISMA-compliant network meta-analysis and literature review. 61
33655951 2021
Effect of selected group of asana when used as an adjunct in management of cervical spondylosis of mild to moderate severity: An observational study. 61
33707125 2021
Optimized acupuncture treatment (acupuncture and intradermal needling) for cervical spondylosis-related neck pain: a multicenter randomized controlled trial. 61
32947547 2021
Laryngeal Mask Use Was Effective for Protecting Against Further Cervical Spine Cord Injury in Patients With Cervical Spondylosis During Electroconvulsive Therapy: Two Case Reports. 61
33661181 2021
Occult Disco-Ligamentous Lesions of the Subaxial c-Spine-A Comparison of Preoperative Imaging Findings and Intraoperative Site Inspection. 61
33807826 2021
Rhizoma drynariae total flavonoids inhibit the inflammatory response and matrix degeneration via MAPK pathway in a rat degenerative cervical intervertebral disc model. 61
33740525 2021
A novel segmentation method for cervical vertebrae based on PointNet++ and converge segmentation. 61
33545639 2021
Public interest in musculoskeletal symptoms and disorders during the COVID-19 pandemic : Infodemiology study. 61
33779835 2021
Effect of Patient Characteristics on Reported Outcomes Over 12 Months Following Lumbar Radiofrequency Ablation: A Retrospective Review of 500 Patients. 61
32654319 2021
Young adults undergoing ACDF surgery exhibit decreased health-related quality of life in the long term in comparison to the general population. 61
33545372 2021
Influence of dynamic neck motion on the clinical usefulness of multi-positional MRI in cervical degenerative spondylosis. 61
33591439 2021
Outcome of Osteophytes After Only-Fixation as Treatment for Multilevel Cervical Spondylosis-A Minimum of 12 Months Follow-Up. 61
33197636 2021
Association of Cervical Spondylosis With Peripheral Vertigo: A Case-Control Study. 61
32396217 2021
Flexion Dysfunction of Atlanto-Occipital Joint Associated with Cervical Spondylosis. 61
33448689 2021
Using internet search data to explore the global public concerns in ankylosing spondylitis. 61
32094142 2021
Radiographic lumbosacral vertebral abnormalities and constipation in cats. 61
33776316 2021
Can Dislocation Rates Be Decreased Using the Anterior Approach in Patients With Lumbar Spondylosis or Lumbar Instrumented Fusion? 61
32919847 2021
A New Classification for Cervical Ossification of the Posterior Longitudinal Ligament Based on the Coexistence of Segmental Disc Degeneration. 61
33105534 2021
Neck Vertebral Level-specific Forces and Moments Under G-x Accelerative Loading. 61
33499473 2021
Anatomy of the posterolateral spinal epidural ligaments. 61
33598349 2021
Gender differences and site-specific incident risks of musculoskeletal disorders among 224 506 workers in the food and beverage service industry in Taiwan: A 15-year Nationwide Population-Based Cohort Study. 61
33728746 2021
Comparative Finite Element Modeling Study of Anterior Cervical Arthrodesis Versus Cervical Arthroplasty With Bryan Disc or Prodisc C. 61
33499493 2021
Retroperitoneal ganglioneuroma causing chronic lower back and leg pain in an 80-year-old man: A case report. 61
33437470 2021
Flat foot and spinal degeneration: Evidence from nationwide population-based cohort study. 61
33423898 2021
Asymptomatic Degenerative Changes in the Lumbar Spine Among Professional Soccer Players. 61
33347092 2021
[Zero profile anchored spacer(ROI-C) for the treatment of cervical spondylosis with osteoporosis]. 61
33666023 2021
Surgical treatment of concomitant atlantoaxial instability and subaxial spondylotic stenosis in rheumatoid arthritis-a case report. 61
33469001 2021
Effects of Percutaneous Neuromuscular Electrical Stimulation for Neck Pain in Patients With Cervical Spondylosis. 61
32088665 2021
Narrative review of intrathecal drug delivery (IDD): indications, devices and potential complications. 61
33569488 2021
A Retrospective Pilot Study for Preoperative Screening to Prevent Iatrogenic Cervical Spinal Cord Injury. 61
33564543 2021
Cervical sagittal alignment in patients with dropped head syndrome. 61
33586511 2021
Association between excessive smartphone use and cervical disc degeneration in young patients suffering from chronic neck pain. 61
32205018 2021
The effect of pestle acupuncture for patients with lactation insufficiency after cesarean section: Study protocol for a randomized controlled trial. 61
33545945 2021
[Exploration on lateral needling technique]. 61
33559441 2021
Analysis of Cervical Spine Alignment Change after Modified Kurokawa Cervical Laminoplasty in the Patients with Cervical Myelopathy and Straight Cervical Spine. 61
33542923 2021
Clinical control study of traditional Chinese medicine hot compress combined with traction in the treatment of cervical spondylotic radiculopathy: Study protocol. 61
33530182 2021
Diagnostic agreement between 3.0-T MRI sequences of nerve root and surgery in patients with cervical radiculopathy: A retrospective study. 61
33530213 2021
Respiratory Compromise After Anterior Cervical Spine Surgery: Incidence, Subsequent Complications, and Independent Predictors. 61
33406919 2021

Variations for Spondylosis

Expression for Spondylosis

Search GEO for disease gene expression data for Spondylosis.

Pathways for Spondylosis

GO Terms for Spondylosis

Cellular components related to Spondylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 S100B PTH KL IL1B HTRA1 ENO2
2 extracellular region GO:0005576 9.28 S100B PTH LIPN KL IL1B HTRA1

Biological processes related to Spondylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.67 VDR PTH ESR1 BMP2
2 positive regulation of ossification GO:0045778 9.32 PTH BMP2
3 bile acid signaling pathway GO:0038183 9.26 VDR HMGCR
4 skeletal system development GO:0001501 9.26 VDR PTH BMP2 ACAN
5 mammary gland branching involved in pregnancy GO:0060745 9.16 VDR ESR1
6 positive regulation of bone mineralization GO:0030501 8.8 PTH KL BMP2

Sources for Spondylosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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