MCID: SPN020
MIFTS: 46

Spondylosis

Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Spondylosis

MalaCards integrated aliases for Spondylosis:

Name: Spondylosis 12 43 15 71 32
Spondylogenic Compression of Thoracic Spinal Cord 12
Spondylogenic Compression of Lumbar Spinal Cord 12
Thoracic or Lumbar Spondylosis with Myelopathy 12
Lumbosacral Spondylosis Without Myelopathy 12
Lumbar Spondylosis with Myelopathy 12
Spondylosis with Myelopathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2247
ICD9CM 34 721.9
MeSH 43 D055009
SNOMED-CT 67 8847002
ICD10 32 M47 M47.9
UMLS 71 C0038019

Summaries for Spondylosis

Disease Ontology : 12 An bone structure disease that involves degeneration between vertebra located in vertebral column.

MalaCards based summary : Spondylosis, also known as spondylogenic compression of thoracic spinal cord, is related to radiculopathy and degenerative disc disease. An important gene associated with Spondylosis is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Parathyroid hormone synthesis, secretion and action and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Pregabalin and Teriparatide have been mentioned in the context of this disorder. Affiliated tissues include vertebral column, spinal cord and bone, and related phenotypes are growth/size/body region and craniofacial

Wikipedia : 74 Spondylosis is the degeneration of the vertebral column from any cause. In the more narrow sense it... more...

Related Diseases for Spondylosis

Diseases related to Spondylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 253)
# Related Disease Score Top Affiliating Genes
1 radiculopathy 31.0 RPL34 BMP2 AVPR2
2 degenerative disc disease 30.6 VDR RPL34 BMP2
3 cerebral palsy 30.6 S100B PTH IL1B
4 head injury 30.4 S100B ENO2
5 ossification of the posterior longitudinal ligament of spine 30.4 TMTC1 BMP2 ADAMTS1
6 brown-sequard syndrome 30.3 TMTC1 ADAMTS1
7 encephalomalacia 30.1 S100B IL1B AVPR2
8 spondylolysis 30.1 RPL34 BMP2
9 arachnoiditis 30.0 TMTC1 RPL34
10 spinal disease 30.0 TMTC1 RPL34 BMP2
11 cauda equina syndrome 29.9 RPL34 KLK8
12 spondylolisthesis 29.7 RPL34 RPL24 KLK8 ESR1 BMP2
13 bone disease 29.3 VDR PTH IL1B ESR1 BMP2
14 osteoporosis 29.2 WRN VDR PTH KL IL1B HMGCR
15 spondylosis, cervical 12.5
16 central cord syndrome 11.6
17 barre-lieou syndrome 11.5
18 cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 11.5
19 spastic paraplegia 25 11.2
20 dysphagia 10.6
21 pediatric ovarian germ cell tumor 10.5 PTH ENO2
22 intracranial cysts 10.5 S100B ENO2
23 pediatric ovarian dysgerminoma 10.5 PTH ENO2
24 bednar tumor 10.5 S100B ENO2
25 exostosis 10.5
26 back pain 10.5
27 protrusio acetabuli 10.5 VDR ESR1
28 meningeal melanocytoma 10.5 S100B ENO2
29 papillary ependymoma 10.5 S100B ENO2
30 pineocytoma 10.5 S100B ENO2
31 spinal stenosis 10.5
32 vulvar vestibulitis syndrome 10.4 IL1B ESR1
33 hyperostosis 10.4
34 hypercalcemia, infantile, 1 10.4 VDR PTH
35 vaginal endometrial stromal sarcoma 10.4 ESR1 ENO2
36 osteoarthritis 10.4
37 post-cardiac arrest syndrome 10.4 S100B ENO2
38 akinetic mutism 10.4 S100B ENO2
39 campylobacteriosis 10.4 VDR IL1B HTRA1
40 spinal cord injury 10.4
41 dental abscess 10.4 PTH KL
42 hypervitaminosis d 10.4 VDR PTH KL
43 phosphorus metabolism disease 10.3 VDR PTH KL
44 parathyroid gland disease 10.3 VDR PTH KL
45 cauda equina neoplasm 10.3 RPL24 ENO2
46 vagina sarcoma 10.3 ESR1 ENO2
47 ossifying fibromyxoid tumor 10.3 S100B ENO2
48 mineral metabolism disease 10.3 VDR PTH KL
49 common peroneal nerve lesion 10.3 RPL34 AVPR2
50 hyperphosphatemia 10.3 VDR PTH KL

Comorbidity relations with Spondylosis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Spondylosis:



Diseases related to Spondylosis

Symptoms & Phenotypes for Spondylosis

MGI Mouse Phenotypes related to Spondylosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ADAMTS1 AVPR2 BMP2 ENO2 ESR1 HELLS
2 craniofacial MP:0005382 9.91 BMP2 ENO2 IL1B KL PTH VDR
3 integument MP:0010771 9.91 AVPR2 ESR1 HELLS IL1B KL RPL24
4 mortality/aging MP:0010768 9.8 ADAMTS1 AVPR2 BMP2 ESR1 HELLS HMGCR
5 limbs/digits/tail MP:0005371 9.76 BMP2 ESR1 HELLS KL PTH RPL24
6 skeleton MP:0005390 9.32 BMP2 ESR1 HELLS HTRA1 IL1B KL

Drugs & Therapeutics for Spondylosis

Drugs for Spondylosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
2
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
3
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
6
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
7 Hormone Antagonists Phase 4
8 glucocorticoids Phase 4
9 Hormones Phase 4
10 Pharmaceutical Solutions Phase 4
11 Anti-Anxiety Agents Phase 4
12 Tranquilizing Agents Phase 4
13 Psychotropic Drugs Phase 4
14 Anticonvulsants Phase 4
15 Calcium, Dietary Phase 4
16 calcium channel blockers Phase 4
17 Anesthetics, Local Phase 4
18 Anti-Arrhythmia Agents Phase 4
19 Sodium Channel Blockers Phase 4
20 Diuretics, Potassium Sparing Phase 4
21 Immunologic Factors Phase 4
22 HIV Protease Inhibitors Phase 4
23
protease inhibitors Phase 4
24 Triamcinolone diacetate Phase 4
25 triamcinolone acetonide Phase 4
26 Immunosuppressive Agents Phase 4
27 Triamcinolone hexacetonide Phase 4
28
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
29
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
30
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
31
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
32 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
33
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
34 Methylprednisolone Acetate Phase 3
35 Neuroprotective Agents Phase 3
36 Protective Agents Phase 3
37
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
38
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
39
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
40
Betamethasone Approved, Vet_approved Phase 2 378-44-9 9782
41
Ibuprofen Approved Phase 2 15687-27-1 3672
42 Anti-Inflammatory Agents Phase 2
43 Antiemetics Phase 2
44 Gastrointestinal Agents Phase 2
45 Autonomic Agents Phase 2
46 BB 1101 Phase 2
47 Antineoplastic Agents, Hormonal Phase 2
48 Anesthetics Phase 2
49 Respiratory System Agents Phase 2
50 Anti-Asthmatic Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 106)
# Name Status NCT ID Phase Drugs
1 Open Labelled Study of Pregabalin in the Treatment of Neuropathic Pain in Cervical Myeloradiculopathy (Pregabalin and Radicular Pain Study (PARPS)) Completed NCT01061697 Phase 4 Pregabalin
2 Assessment of the Efficacy of Forteo (Teriparatide) in Patients Undergoing Posterolateral Lumbar Spinal Fusion Completed NCT01292252 Phase 4
3 A Prospective Randomized Controlled Trial of Standardized C7-T1 Epidural Steroid Injections Versus Targeted Injection Via Cervical Epidural Catheter for the Treatment of Cervical Radicular Pain Completed NCT02095197 Phase 4 Triamcinolone 80mg
4 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
5 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
6 Randomized Prospective Study of Particulate Corticosteroid Versus Non-particulate Corticosteroid for Sacroiliac Joint Steroid Injection Enrolling by invitation NCT03166761 Phase 4 Dexamethasone;Triamcinolone Acetonide
7 A Prospective, Randomized, Multi-Center, Post-Approval Clinical Trial Evaluating the Long-Term (7 Year) Safety and Effectiveness of the PCM® Cervical Disc Completed NCT01905930 Phase 3
8 The CSM Trial: A Multicenter Study Comparing Ventral to Dorsal Surgery for Cervical Spondylotic Myelopathy Completed NCT00506558 Phase 3
9 A Prospective, Randomized, Controlled Clinical Investigation Comparing PCM® Cervical Disc Arthroplasty to Anterior Cervical Discectomy and Fusion: 2 Year Results From the US IDE Clinical Trial Completed NCT00578812 Phase 3
10 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Recruiting NCT03327272 Phase 3 Methylprednisolone;Saline
11 ASIA Motor, Functional and Health Related Quality of Life Outcome in Traumatic Central Cord Syndrome, a Prospective Randomized Study Unknown status NCT00475748 Phase 2
12 A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain: Evaluate Route Versus Pharmacology of Intervention, and Feasibility in Public Hospital and Community Practice Settings. Unknown status NCT03240783 Phase 2 Betamethasone OR Dexamethasone Injectable;Normal Saline Flush, 0.9% Injectable Solution;Dexamethasone Oral Tablet
13 Effect of Conservative Treatment With Cervical Collar in Patients With Cervical Radiculopathy and Radicular Pain. A Randomized Controlled Study Completed NCT00395798 Phase 2
14 NGHIÊN CỨU NGẪU NHIÊN, MÙ ĐÔI, CÓ ĐỐI CHỨNG TRONG ĐIỀU TRỊ HỘI CHỨNG CỔ VAI CÁNH TAY CỦA VIÊN NANG CỨNG TD 0019 (A Randomized, Double Blind, Placebo Controlled, Parallel Group, Phase 3 Trial to Evaluate the Satety and Efficacy of Therapy With Hard Capsule TD0019 in Cervical Scapulohumeral Syndrome) Completed NCT03845959 Phase 2 TD0019 oral capsule;Placebo oral capsule
15 Proposal to Evaluate the Efficacy of the InterX 5000 in the Treatment of Chronic Neck and Shoulder Pain Completed NCT00587626 Phase 2
16 Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery Terminated NCT02276911 Phase 2 Ibuprofen
17 A Muti-Center Study Comparing 3 Procedures for Bi-level Cervical Spondylosis Unknown status NCT03358225
18 Study on the Early Warning and Treatment of Cervical Spondylosis of Cervical Type on Young People Based on the " Move Generate Yang " Theory Unknown status NCT02199405
19 Evaluation on Efficacy of Total Artificial Disc Replacement (TDR) of Cervical Spondylosis: a Cohort Prospective Follow-up for 5 Years Unknown status NCT03364816
20 Physical Therapy Management in Degenerative Lumbar Diseases and Osteoporosis Unknown status NCT01703403
21 Recovery Profiles After c Spine Surgery: With or Without Dexmedetomidine as an Anesthetic Adjuvant Unknown status NCT02819089 Dexmedetomidine
22 Pilot Study of Efficacy and Safety of Acupuncture on Patient With Spinal Pain Due to Spondylolithesis Unknown status NCT01909284
23 The Effects of Diabetes and Glycosylation Profile on Outcomes in the Surgical Treatment of Cervical Spondylosis Unknown status NCT02758899
24 Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study Unknown status NCT02873182
25 Evaluation of Aspen Spinous Process Fixation System and PLIF Technique for the Treatment of Low Back Pain in the Presence of Lumbar Instability and Degenerative Disk Disease Unknown status NCT01918943
26 Decompressive Cervical Surgery for Antihypertensive Effect in Patients With Cervical Spondylosis and Hypertension-A Cohort Study Unknown status NCT02016768
27 Balance Chiropractic Therapy for Cervical Spondylotic Radiculopathy: a Randomized Parallel-controlled Trial Unknown status NCT02705131
28 A Prospective Study Using Actifuse SHAPE Versus Autograft With Demineralized Bone Matrix to Achieve Bone Fusion in Anterior Cervical Corpectomy (ACC) Unknown status NCT02005081
29 Diffusion Tensor Imaging of the Brain and Cervical Spine: Evaluation of Reproducibility in Normal Subjects and Diagnostic Utility in Patients With Cervical Spondylotic Myelopathy Completed NCT01868958
30 Effectiveness of Yoga Therapy for Neck Pain Relief in Patients With Cervical Spondylosis Completed NCT04113473
31 Structural Spinal Cord Integrity in Patients With Cervical Spondylosis in Relation to Clinical Status Completed NCT01243684
32 Yoga Chikitsa for Neck Pain Caused by Cervical Spondylosis: a Randomized Controlled Pilot Trial Completed NCT03526965 Usual care
33 Efficacy and Safety of OsteoStrux™ Collagen Ceramic Scaffold in Instrumented Lumbar Spine Fusion Completed NCT01873586
34 Efficacy and Safety of Integra Accell Evo3™ Demineralized Bone Matrix in Instrumented Lumbar Spine Fusion Completed NCT02018445
35 Comparison Between Segmental Mobilization And Entire Spine Mobilization In Lumbar Spondylosis Completed NCT04158115
36 A Prospective Study Comparison of Clinical Outcome After Different Rate Infusion in Caudal Epidural Steroid Injection Completed NCT02939482 Triamcinolone Acetonide and normal saline solution
37 Prospective Clinical Evaluation of the New Aegis Plate for Anterior Interbody Completed NCT00555659
38 Evaluation and Physical Therapy for Patients With Degenerated Cervical Spine Completed NCT00162890
39 The Effect of Nuchal Ligament Calcification on Cervical Function in Patients With Neck Pain Completed NCT02362555
40 Treatment of Cervical Radiculopathy With Arthroplasty Compared With Discectomy With Fusion and Cage (ACDF. Clinical, Radiological and Biomechanical Aspects. A Randomized Multicenter Study. Completed NCT00735176
41 A Randomized Controlled Trial of Conservative Therapy in Cervical Radiculopathy Completed NCT00129714
42 Efficacy and Safety of Integra Accell Evo3 Demineralized Bone Matrix Instrumented Posterolateral Lumbar Spine Fusion Completed NCT01430299
43 Efficacy and Safety of Integra Accell Evo3 Demineralized Bone Matrix in Instrumented Lumbar Spine Fusion Completed NCT01714804
44 Allograft Alone Versus Allograft With Bone Marrow Concentrate for the Healing of the Instrumented Posterolateral Lumbar Fusion Completed NCT01603836
45 White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord - Pilot Study Completed NCT00280306
46 Does Inhalational Anesthesia Accelerate Postoperative Cognitive Decline? Completed NCT00788008 inhalation anesthesia with isoflurane vs. TIVA with propofol
47 Effectiveness of Balance Training With Kinesthetic Ability Trainer-KAT2000 in Patients With Peripheral Neuropathic Pain: a Randomized Controlled Study Completed NCT03359772
48 The Efficacy/Safety Profile Of Pulsed Shortwave Therapy in Cervical Osteoarthritis: A Comparison Study Against Etoricoxib Completed NCT03542955 Etoricoxib 60 mg
49 The Characteristics of Regional Bone Quality in the Cervical Vertebrae Considering BMD Completed NCT02995798
50 Clinical Trial on Performance and Acceptance of a New Robotic Assistance System During Spinal Fusion Surgery Completed NCT02558621

Search NIH Clinical Center for Spondylosis

Cochrane evidence based reviews: spondylosis

Genetic Tests for Spondylosis

Anatomical Context for Spondylosis

The Foundational Model of Anatomy Ontology organs/tissues related to Spondylosis:

19
Vertebral Column

MalaCards organs/tissues related to Spondylosis:

40
Spinal Cord, Bone, Testes, Heart, Brain, Bone Marrow, Cortex

Publications for Spondylosis

Articles related to Spondylosis:

(show top 50) (show all 3158)
# Title Authors PMID Year
1
Reoperation for Late Neurological Deterioration After Laminoplasty in Individuals with Degenerative Cervical Myelopathy: Comparison of Cases of Cervical Spondylosis and Ossification of the Posterior Longitudinal Ligament. 61
32032323 2020
2
The value of dynamic MRI in the treatment of cervical spondylotic myelopathy: a protocol for a prospective randomized clinical trial. 61
32033548 2020
3
Analysis of pathological parameters of cervical spondylotic myelopathy using magnetic resonance imaging. 61
31846844 2020
4
Influence of extending expansive open-door laminoplasty to C1 and C2 on cervical sagittal parameters. 61
32024507 2020
5
The Influence of Depression on Health Care Expenditures Among Adults with Spondylosis, Intervertebral Disc Disorders, and Other Back Problems in the United States. 61
30445578 2020
6
MRI evidence of brain atrophy, white matter damage, and functional adaptive changes in patients with cervical spondylosis and prolonged spinal cord compression. 61
31350584 2020
7
Meta-analysis of the therapeutic effect of acupuncture and chiropractic on cervical spondylosis radiculopathy: A systematic review and meta-analysis protocol. 61
32000386 2020
8
The Magnetic Resonance Imaging Research of Thoracic Inlet Parameters at Cervical and Cervicothoracic Spine in Degenerative Cervical Spondylosis. 61
31958587 2020
9
Nondrug therapies for hypertensive patients complicated with cervical spondylosis: A systematic review and meta-analysis. 61
32000442 2020
10
Epidemiological survey and risk factor analysis of dialysis-related amyloidosis including destructive spondyloarthropathy, dialysis amyloid arthropathy, and carpal tunnel syndrome. 61
31414282 2020
11
Spectrum of musculoskeletal disorders in Nigerians with types 2 diabetes mellitus: prevalence and predictors. 61
31995960 2020
12
Application of a modified surgical position in anterior approach for total cervical artificial disc replacement. 61
31970168 2020
13
Comprehensive Analysis of Hybrid Surgery and Anterior Cervical Discectomy and Fusion in Cervical Diseases: A Meta-Analysis. 61
32000453 2020
14
Cervical spondylotic internal jugular venous compression syndrome. 61
31119898 2020
15
The role of cervical collar in functional restoration and fusion after anterior cervical discectomy and fusion without plating on single or double levels: a systematic review and meta-analysis. 61
31894403 2020
16
Kinetic magnetic resonance imaging analysis of thoracolumbar segmental mobility in patients without significant spondylosis. 61
31914013 2020
17
The precarious use of charm needles susuk in treatment of low back pain by traditional medicine practitioners and its possible risk to patient safety. 61
32008027 2020
18
Non-iatrogenic spontaneous acute spinal subdural haematoma after transforaminal lumbar interbody fusion. 61
31918576 2020
19
The Effectiveness of Fluoroscopically Guided Cervical Transforaminal Epidural Steroid Injection for the Treatment of Radicular Pain; a Systematic Review and Meta-analysis. 61
31181148 2020
20
Surgical Back Risk Syndrome and Spinal Cord Stimulation: Better Safe Than Sorry. 61
31574335 2020
21
Reperfusion "White Cord'' Syndrome in Cervical Spondylotic Myelopathy: Does Mean Arterial Pressure Goal Make a Difference? Additional Case and Literature Review. 61
31954909 2020
22
Association Between Diaphragmatic Paralysis and Ipsilateral Cervical Spondylosis on MRI. 61
31535202 2019
23
Anterior Spinal Artery Syndrome in a Patient with Cervical Spondylosis Demonstrated by CT Angiography. 61
31680448 2019
24
[Acupuncture combined with Jingtong granule for nerve-root type cervical spondylosis and its effects on IL-6、TNF-α、IL-1β and hemorheological indexes]. 61
31820601 2019
25
The effect of renin-angiotensin system blockers on spinal cord dysfunction and imaging features of spinal cord compression in patients with symptomatic cervical spondylosis. 61
31821888 2019
26
TNF-α induces apoptosis of human nucleus pulposus cells via activating the TRIM14/NF-κB signalling pathway. 61
31322007 2019
27
Cost-Effectiveness of Jingshu Granules Compared to Placebo for the Treatment of Patients with Cervical Radiculopathy in China: A Decision-Tree Model Based on Randomized Controlled Trial. 61
31634001 2019
28
Indian Morinda species: A review. 61
31840355 2019
29
Reoperation rate after anterior cervical discectomy and fusion using standalone cages in degenerative disease: a study of 2,078 cases. 61
31404654 2019
30
MicroRNA-204 silencing relieves pain of cervical spondylotic radiculopathy by targeting GDNF. 61
31819204 2019
31
Pillow preferences of people with neck pain and known spinal degeneration: a pilot randomized controlled trial. 61
31489809 2019
32
Cervical Myelopathy without Symptoms in the Upper Extremities: Incidence and Presenting Characteristics. 61
31513953 2019
33
Lumbar 3-Lumbar 5 Robotic-Assisted Endoscopic Transforaminal Lumbar Interbody Fusion: 2-Dimensional Operative Video. 61
31811291 2019
34
Preoperative SPECT imaging as a tool for surgical planning in patients with axial neck and back pain. 61
31786563 2019
35
[Influence of different courses of electroacupuncture treatment on compliance and therapeutic outcome of patients with cervical type cervical spondylosis: a small-sample randomized controlled trial]. 61
31777235 2019
36
Assessment of the efficacy of acupuncture and chiropractic on treating Cervical spondylosis radiculopathy: A systematic review and meta-analysis. 61
31770206 2019
37
Neck disability in patients with cervical spondylosis is associated with altered brain functional connectivity. 61
31420276 2019
38
Multilevel instrumented posterolateral lumbar spine fusion with an allogeneic cellular bone graft. 61
31730007 2019
39
Demographics of Patients Undergoing Carpal Tunnel Release in an Urban Tertiary Hospital in Malaysia. 61
31890111 2019
40
Dissociated lower limb muscle involvement in amyotrophic lateral sclerosis and its differential diagnosis value. 61
31780761 2019
41
Multivariate analysis of factors related to the absence of musculoskeletal degenerative disease in middle-aged and older people. 61
31746530 2019
42
A Case of Leukoencephalopathy and Small Vessels Disease Caused by a Novel HTRA1 Homozygous Mutation. 61
31494012 2019
43
Lumbar thoracolumbar interfascial plane block provides effective analgesia for spondylosis. 61
30851502 2019
44
Prevalence of Spondylosis Deformans in Tailed Versus Tail-Docked Rottweilers. 61
31525089 2019
45
A Novel Hybrid Endoscopic Approach for Anterior Cervical Discectomy and Fusion and a Meta-Analysis of the Literature. 61
31349080 2019
46
Biomechanical Comparison of Optimal Shapes for the Cervical Intervertebral Fusion Cage for C5-C6 Cervical Fusion Using the Anterior Cervical Plate and Cage (ACPC) Fixation System: A Finite Element Analysis. 61
31697650 2019
47
Is there a difference in the grade of degeneration at the cervical spine following anterior cervical fusion with respect to clinical outcome, diagnosis, and repeat procedure? An MRI study of 102 patients with a mean follow-up of 25 years. 61
31783354 2019
48
Biomechanical Analysis of Stand-alone Lateral Lumbar Interbody Fusion for Lumbar Adjacent Segment Disease. 61
31890409 2019
49
Radiological and clinical outcomes of 3-level cervical disc arthroplasty. 61
31675702 2019
50
Evaluation criteria for the assessment of occupational diseases of the lumbar spine - how reliable are they? 61
31656177 2019

Variations for Spondylosis

Expression for Spondylosis

Search GEO for disease gene expression data for Spondylosis.

Pathways for Spondylosis

Pathways related to Spondylosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 VDR PTH KL
2 10.79 VDR PTH IL1B
3 10.65 VDR PTH KL ESR1
4 10.16 VDR PTH

GO Terms for Spondylosis

Cellular components related to Spondylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 SPX S100B PTH KLK8 KL IL1B
2 extracellular space GO:0005615 9.28 SPX S100B PTH KLK8 KL IL1B

Biological processes related to Spondylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of ossification GO:0045778 9.32 PTH BMP2
2 positive regulation of systemic arterial blood pressure GO:0003084 9.26 SPX AVPR2
3 negative regulation of renal sodium excretion GO:0035814 9.16 SPX AVPR2
4 positive regulation of bone mineralization GO:0030501 9.13 PTH KL BMP2
5 mammary gland branching involved in pregnancy GO:0060745 8.62 VDR ESR1

Molecular functions related to Spondylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 SPX PTH KL
2 vitamin D binding GO:0005499 8.62 VDR KL

Sources for Spondylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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