Aliases & Classifications for Spondylosis, Cervical

MalaCards integrated aliases for Spondylosis, Cervical:

Name: Spondylosis, Cervical 56
Cervical Spondylosis 17

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
spondylosis, cervical:
Inheritance autosomal dominant inheritance


Summaries for Spondylosis, Cervical

MalaCards based summary : Spondylosis, Cervical, also known as cervical spondylosis, is related to central cord syndrome and barre-lieou syndrome. The drugs Pregabalin and Calcium have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and heart, and related phenotypes are osteoarthritis and spondylolisthesis

More information from OMIM: 184300

Related Diseases for Spondylosis, Cervical

Diseases related to Spondylosis, Cervical via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 central cord syndrome 11.7
2 barre-lieou syndrome 11.7
3 spondylosis 10.9
4 ossification of the posterior longitudinal ligament of spine 10.5
5 syringomyelia, noncommunicating isolated 10.4
6 syringomyelia 10.4
7 vertebrobasilar insufficiency 10.4
8 amyotrophic lateral sclerosis 1 10.4
9 lateral sclerosis 10.4
10 spinal stenosis 10.4
11 vertebral artery insufficiency 10.3
12 quadriplegia 10.3
13 radiculopathy 10.3
14 headache 10.3
15 locked-in syndrome 10.2
16 candidiasis, familial, 1 10.2
17 multiple sclerosis 10.2
18 osteoporosis 10.2
19 sarcoidosis 1 10.2
20 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
21 bone mineral density quantitative trait locus 8 10.2
22 bone mineral density quantitative trait locus 15 10.2
23 angina pectoris 10.2
24 spinal disease 10.2
25 hyperostosis 10.2
26 motor neuron disease 10.2
27 myelitis 10.2
28 ischemia 10.2
29 anterior spinal artery syndrome 10.2
30 carpal tunnel syndrome 10.1
31 rheumatoid arthritis 10.1
32 torticollis 10.1
33 cervical dystonia 10.1
34 respiratory failure 10.1
35 heart disease 10.1
36 pica disease 10.1
37 neurosarcoidosis 10.1
38 basilar artery insufficiency 10.1
39 periarthritis 10.1
40 spinal cord disease 10.1
41 peripheral nervous system disease 10.1
42 brown-sequard syndrome 10.1
43 muscular atrophy 10.1
44 neuropathy 10.1
45 chronic pain 10.1
46 myoclonus 10.1
47 whiplash 10.1
48 rare surgical neurologic disease 10.1
49 gastroesophageal reflux 9.9
50 ige responsiveness, atopic 9.9

Graphical network of the top 20 diseases related to Spondylosis, Cervical:



Diseases related to Spondylosis, Cervical

Symptoms & Phenotypes for Spondylosis, Cervical

Human phenotypes related to Spondylosis, Cervical:

31
# Description HPO Frequency HPO Source Accession
1 osteoarthritis 31 HP:0002758
2 spondylolisthesis 31 HP:0003302
3 spina bifida occulta 31 HP:0003298
4 cervical spondylosis 31 HP:0008480
5 spondylolysis 31 HP:0003304

Symptoms via clinical synopsis from OMIM:

56
Joints:
osteoarthritis

Spine:
spondylolisthesis
spina bifida occulta
cervical spondylosis
spondylolysis
transitional lumbar-sacral vertebra

Clinical features from OMIM:

184300

Drugs & Therapeutics for Spondylosis, Cervical

Drugs for Spondylosis, Cervical (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Anti-Anxiety Agents Phase 4
4 Central Nervous System Depressants Phase 4
5 Hormones Phase 4
6 Tranquilizing Agents Phase 4
7 Psychotropic Drugs Phase 4
8 Anticonvulsants Phase 4
9 Calcium, Dietary Phase 4
10 calcium channel blockers Phase 4
11
Ibuprofen Approved Phase 2 15687-27-1 3672
12 Analgesics Phase 2
13 Narcotics Phase 2
14 Anti-Inflammatory Agents Phase 2
15 Anti-Inflammatory Agents, Non-Steroidal Phase 2
16 Analgesics, Opioid Phase 2
17 Analgesics, Non-Narcotic Phase 2
18 Cyclooxygenase Inhibitors Phase 2
19 Antirheumatic Agents Phase 2
20
Meloxicam Approved, Vet_approved 71125-38-7 5281106 54677470
21
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
22
alemtuzumab Approved, Investigational 216503-57-0
23 Neurotransmitter Agents
24 Anesthetics
25 Adrenergic Agonists
26 Adrenergic alpha-2 Receptor Agonists
27 Adjuvants, Anesthesia
28 Hypnotics and Sedatives
29 Adrenergic Agents
30 Antihypertensive Agents
31 Antineoplastic Agents, Immunological

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Open Labelled Study of Pregabalin in the Treatment of Neuropathic Pain in Cervical Myeloradiculopathy (Pregabalin and Radicular Pain Study (PARPS)) Completed NCT01061697 Phase 4 Pregabalin
2 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
3 The CSM Trial: A Multicenter Study Comparing Ventral to Dorsal Surgery for Cervical Spondylotic Myelopathy Completed NCT00506558 Phase 3
4 ASIA Motor, Functional and Health Related Quality of Life Outcome in Traumatic Central Cord Syndrome, a Prospective Randomized Study Unknown status NCT00475748 Phase 2
5 Effect of Conservative Treatment With Cervical Collar in Patients With Cervical Radiculopathy and Radicular Pain. A Randomized Controlled Study Completed NCT00395798 Phase 2
6 NGHIÊN CỨU NGẪU NHIÊN, MÙ ĐÔI, CÓ ĐỐI CHỨNG TRONG ĐIỀU TRỊ HỘI CHỨNG CỔ VAI CÁNH TAY CỦA VIÊN NANG CỨNG TD 0019 (A Randomized, Double Blind, Placebo Controlled, Parallel Group, Phase 3 Trial to Evaluate the Satety and Efficacy of Therapy With Hard Capsule TD0019 in Cervical Scapulohumeral Syndrome) Completed NCT03845959 Phase 2 TD0019 oral capsule;Placebo oral capsule
7 Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery Terminated NCT02276911 Phase 2 Ibuprofen
8 Evaluation on Efficacy of Total Artificial Disc Replacement (TDR) of Cervical Spondylosis: a Cohort Prospective Follow-up for 5 Years Unknown status NCT03364816
9 A Muti-Center Study Comparing 3 Procedures for Bi-level Cervical Spondylosis Unknown status NCT03358225
10 Study on the Early Warning and Treatment of Cervical Spondylosis of Cervical Type on Young People Based on the " Move Generate Yang " Theory Unknown status NCT02199405
11 Recovery Profiles After c Spine Surgery: With or Without Dexmedetomidine as an Anesthetic Adjuvant Unknown status NCT02819089 Dexmedetomidine
12 The Effects of Diabetes and Glycosylation Profile on Outcomes in the Surgical Treatment of Cervical Spondylosis Unknown status NCT02758899
13 Decompressive Cervical Surgery for Antihypertensive Effect in Patients With Cervical Spondylosis and Hypertension-A Cohort Study Unknown status NCT02016768
14 Balance Chiropractic Therapy for Cervical Spondylotic Radiculopathy: a Randomized Parallel-controlled Trial Unknown status NCT02705131
15 Effectiveness of Yoga Therapy for Neck Pain Relief in Patients With Cervical Spondylosis Completed NCT04113473
16 Structural Spinal Cord Integrity in Patients With Cervical Spondylosis in Relation to Clinical Status Completed NCT01243684
17 Yoga Chikitsa for Neck Pain Caused by Cervical Spondylosis: a Randomized Controlled Pilot Trial Completed NCT03526965 Usual care
18 Evaluation and Physical Therapy for Patients With Degenerated Cervical Spine Completed NCT00162890
19 The Effect of Nuchal Ligament Calcification on Cervical Function in Patients With Neck Pain Completed NCT02362555
20 White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord - Pilot Study Completed NCT00280306
21 The CX-DZ-Ⅱ Intelligent Electroacupuncture Instrument for Neck Pain Completed NCT03005301
22 Diffusion Tensor Imaging of the Brain and Cervical Spine: Evaluation of Reproducibility in Normal Subjects and Diagnostic Utility in Patients With Cervical Spondylotic Myelopathy Completed NCT01868958
23 PATIENT-REPORTED-OUTCOMES IN CHRONIC CERVICAL PAIN PATIENTS WITH ACCOMPANYING UPPER LIMB RADIATING PAIN (NEUROPATHIC COMPONENT) TREATED WITH PREGABALIN IN PRIMARY CARE SETTINGS Completed NCT02868359
24 Establishing the Pathophysiology of Primary Spinal Syringomyelia Completed NCT00011245
25 An Assessment of Surgical Techniques for Treating Cervical Spondylotic Myelopathy Completed NCT00285337
26 The Effect of Noxipoint™ Therapy Versus Physical Therapy With Transcutaneous Electrical Never Stimulation on Chronic Cervical Pain Completed NCT01844167
27 Predictive Value of Diffusion MRI in Cervical Spondylotic Myelopathy Recruiting NCT03296592
28 Predictors of Outcome and Natural History in Patients With Cervical Spondylotic Myelopathy Recruiting NCT02936245
29 A Comparison of Anterior and Posterior Procedures for the Surgical Management of Cervical Spondylotic Myelopathy: Prospective Randomized Clinical Trial Recruiting NCT00876603
30 Clinical and Radiological Outcomes of Posterior Cervical Fusion Supplemented With Interfacet Spacers Recruiting NCT04041583
31 FUSION EVALUATION AFTER ANTERIOR CERVICAL DISCECTOMY AND FUSION WITH STAND ALONE LOCKING CAGE WITH BLADE HRCC® Recruiting NCT03950349
32 A Multi-Center, Prospective, Single-Arm Study of Patients Undergoing a Two or Three Level ACDF Using ViviGen Cellular Bone Matrix in Conjunction With Cervical Allograft Spacers and DePuy Synthes Spine Anterior Cervical Plate Systems Active, not recruiting NCT02814825
33 Cervical Spondylotic Myelopathy Surgical Trial Active, not recruiting NCT02076113
34 Motor Evoked Potentials as a Biomarker in Alemtuzumab Treated Multiple Sclerosis Patients Active, not recruiting NCT02623946
35 Collar Immobilization Following a Posterior Cervical Laminectomy and Fusion: A Randomized Controlled Trial Terminated NCT01383876
36 Evaluation of DTRAX Graft in Patients With Cervical Degenerative Disc Disease Withdrawn NCT01616719
37 Comparison of Outcomes After ACDF Using Allograft Fusion Versus PEEK Fusion: a Prospective Clinical Trial Withdrawn NCT03187171
38 Magnetic Resonance Imaging of the Spine Withdrawn NCT01382290

Search NIH Clinical Center for Spondylosis, Cervical

Genetic Tests for Spondylosis, Cervical

Anatomical Context for Spondylosis, Cervical

MalaCards organs/tissues related to Spondylosis, Cervical:

40
Spinal Cord, Bone, Heart, Brain, Cortex, Testes, Skin

Publications for Spondylosis, Cervical

Articles related to Spondylosis, Cervical:

(show top 50) (show all 1722)
# Title Authors PMID Year
1
A possible genetic factor in cervical spondylosis. 61 56
5782795 1969
2
Familial occurrence of lumbar spondylolysis and spondylolisthesis. 56
668183 1978
3
Reoperation for Late Neurological Deterioration After Laminoplasty in Individuals with Degenerative Cervical Myelopathy: Comparison of Cases of Cervical Spondylosis and Ossification of the Posterior Longitudinal Ligament. 61
32032323 2020
4
The value of dynamic MRI in the treatment of cervical spondylotic myelopathy: a protocol for a prospective randomized clinical trial. 61
32033548 2020
5
Analysis of pathological parameters of cervical spondylotic myelopathy using magnetic resonance imaging. 61
31846844 2020
6
Influence of extending expansive open-door laminoplasty to C1 and C2 on cervical sagittal parameters. 61
32024507 2020
7
MRI evidence of brain atrophy, white matter damage, and functional adaptive changes in patients with cervical spondylosis and prolonged spinal cord compression. 61
31350584 2020
8
Meta-analysis of the therapeutic effect of acupuncture and chiropractic on cervical spondylosis radiculopathy: A systematic review and meta-analysis protocol. 61
32000386 2020
9
The Magnetic Resonance Imaging Research of Thoracic Inlet Parameters at Cervical and Cervicothoracic Spine in Degenerative Cervical Spondylosis. 61
31958587 2020
10
The role of cervical collar in functional restoration and fusion after anterior cervical discectomy and fusion without plating on single or double levels: a systematic review and meta-analysis. 61
31894403 2020
11
Nondrug therapies for hypertensive patients complicated with cervical spondylosis: A systematic review and meta-analysis. 61
32000442 2020
12
Application of a modified surgical position in anterior approach for total cervical artificial disc replacement. 61
31970168 2020
13
Comprehensive Analysis of Hybrid Surgery and Anterior Cervical Discectomy and Fusion in Cervical Diseases: A Meta-Analysis. 61
32000453 2020
14
Cervical spondylotic internal jugular venous compression syndrome. 61
31119898 2020
15
Anterior Spinal Artery Syndrome in a Patient with Cervical Spondylosis Demonstrated by CT Angiography. 61
31680448 2019
16
Association Between Diaphragmatic Paralysis and Ipsilateral Cervical Spondylosis on MRI. 61
31535202 2019
17
TNF-α induces apoptosis of human nucleus pulposus cells via activating the TRIM14/NF-κB signalling pathway. 61
31322007 2019
18
[Acupuncture combined with Jingtong granule for nerve-root type cervical spondylosis and its effects on IL-6、TNF-α、IL-1β and hemorheological indexes]. 61
31820601 2019
19
The effect of renin-angiotensin system blockers on spinal cord dysfunction and imaging features of spinal cord compression in patients with symptomatic cervical spondylosis. 61
31821888 2019
20
Cost-Effectiveness of Jingshu Granules Compared to Placebo for the Treatment of Patients with Cervical Radiculopathy in China: A Decision-Tree Model Based on Randomized Controlled Trial. 61
31634001 2019
21
MicroRNA-204 silencing relieves pain of cervical spondylotic radiculopathy by targeting GDNF. 61
31819204 2019
22
Indian Morinda species: A review. 61
31840355 2019
23
Reoperation rate after anterior cervical discectomy and fusion using standalone cages in degenerative disease: a study of 2,078 cases. 61
31404654 2019
24
Pillow preferences of people with neck pain and known spinal degeneration: a pilot randomized controlled trial. 61
31489809 2019
25
Assessment of the efficacy of acupuncture and chiropractic on treating Cervical spondylosis radiculopathy: A systematic review and meta-analysis. 61
31770206 2019
26
[Influence of different courses of electroacupuncture treatment on compliance and therapeutic outcome of patients with cervical type cervical spondylosis: a small-sample randomized controlled trial]. 61
31777235 2019
27
Neck disability in patients with cervical spondylosis is associated with altered brain functional connectivity. 61
31420276 2019
28
Demographics of Patients Undergoing Carpal Tunnel Release in an Urban Tertiary Hospital in Malaysia. 61
31890111 2019
29
A Novel Hybrid Endoscopic Approach for Anterior Cervical Discectomy and Fusion and a Meta-Analysis of the Literature. 61
31349080 2019
30
Biomechanical Comparison of Optimal Shapes for the Cervical Intervertebral Fusion Cage for C5-C6 Cervical Fusion Using the Anterior Cervical Plate and Cage (ACPC) Fixation System: A Finite Element Analysis. 61
31697650 2019
31
Esophagus type cervical spondylosis. 61
30981870 2019
32
Changes in reaching skill in patients with cervical spondylosis after cervical decompression surgery. 61
31645802 2019
33
Cervical proprioception and its relationship with neck pain intensity in subjects with cervical spondylosis. 61
31615495 2019
34
Distinguishing scrub typhus-related deltoid paralysis from cervical spondylosis in an elderly patient: a case report. 61
31154558 2019
35
Preoperative imaging differences of patients with cervical spondylosis with cervical vertigo indicate the prognosis after cervical total disc replacement. 61
31640443 2019
36
Comparison of Anterior Cervical Decompression and Fusion versus Laminoplasty in the Treatment of Multilevel Cervical Spondylotic Myelopathy: A Meta-Analysis of Clinical and Radiological Outcomes. 61
31254693 2019
37
[Study on the use of CT three-dimensional reconstruction technique for guiding tracheal intubation with rigid fiber bronchoscope in difficult airway]. 61
31624391 2019
38
Adjacent segment motion following multi-level ACDF: a kinematic and clinical study in patients with zero-profile anchored spacer or plate. 61
31428860 2019
39
Surgical outcomes for distal-type cervical spondylotic amyotrophy: a multicenter retrospective analysis of 43 cases. 61
31290024 2019
40
[Advances in research of cervical spondylotic amyotrophy]. 61
31474064 2019
41
Clinical effectiveness and safety of acupotomy: An overview of systematic reviews. 61
31383431 2019
42
Spinal Cord Perfusion MR Imaging Implicates Both Ischemia and Hypoxia in the Pathogenesis of Cervical Spondylosis. 61
31077900 2019
43
Chronic myelitis associated with zoster sine herpete: A case report. 61
31393366 2019
44
Acupotomy versus acupuncture for cervical spondylotic radiculopathy: protocol of a systematic review and meta-analysis. 61
31399459 2019
45
Effect and Safety of CX-DZ-II Intelligent Electroacupuncture Therapeutic Instrument for Neck Pain Caused by Cervical Spondylos: Study Protocol for A Randomized Controlled Trial. 61
31372917 2019
46
Comparison of radiographic parameters after anterior cervical discectomy and fusion with semiconstrained translational versus rotational plate systems. 61
31176235 2019
47
Comparison of the Biomechanical Changes After Percutaneous Full-Endoscopic Anterior Cervical Discectomy versus Posterior Cervical Foraminotomy at C5-C6: A Finite Element-Based Study. 61
31096026 2019
48
[In vivo measurement of three-dimensional motion of the upper cervical spine using CT three-dimensional reconstruction]. 61
31382726 2019
49
Cervical spondylosis in patients presenting with "severe" myelopathy: Analysis of treatment by multisegmental spinal fixation - A case series. 61
31772426 2019
50
Ergonomic Latex Pillows as a Part of a Multimodal Intervention or as an Adjunct to Rehabilitation Programs in Cervical Spondylosis: Are They Useful?: A Randomized Controlled Trial. 61
30741761 2019

Variations for Spondylosis, Cervical

Expression for Spondylosis, Cervical

Search GEO for disease gene expression data for Spondylosis, Cervical.

Pathways for Spondylosis, Cervical

GO Terms for Spondylosis, Cervical

Sources for Spondylosis, Cervical

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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