Aliases & Classifications for Spondylosis, Cervical

MalaCards integrated aliases for Spondylosis, Cervical:

Name: Spondylosis, Cervical 57
Cervical Spondylosis 17

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
spondylosis, cervical:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 57 184300
MedGen 42 C1384641

Summaries for Spondylosis, Cervical

MalaCards based summary : Spondylosis, Cervical, also known as cervical spondylosis, is related to central cord syndrome and barre-lieou syndrome. The drugs Pregabalin and Calcium have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related phenotypes are osteoarthritis and spondylolisthesis

More information from OMIM: 184300

Related Diseases for Spondylosis, Cervical

Diseases related to Spondylosis, Cervical via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 central cord syndrome 11.7
2 barre-lieou syndrome 11.7
3 spondylosis 10.9
4 ossification of the posterior longitudinal ligament of spine 10.5
5 exostosis 10.5
6 syringomyelia, noncommunicating isolated 10.4
7 syringomyelia 10.4
8 vertebrobasilar insufficiency 10.4
9 amyotrophic lateral sclerosis 1 10.4
10 lateral sclerosis 10.4
11 spinal stenosis 10.4
12 vertebral artery insufficiency 10.3
13 radiculopathy 10.3
14 quadriplegia 10.3
15 headache 10.3
16 multiple sclerosis 10.2
17 locked-in syndrome 10.2
18 candidiasis, familial, 1 10.2
19 osteoporosis 10.2
20 rheumatoid arthritis 10.2
21 sarcoidosis 1 10.2
22 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
23 bone mineral density quantitative trait locus 8 10.2
24 bone mineral density quantitative trait locus 15 10.2
25 angina pectoris 10.2
26 spinal disease 10.2
27 hyperostosis 10.2
28 motor neuron disease 10.2
29 myelitis 10.2
30 ischemia 10.2
31 spasticity 10.2
32 spinal cord infarction 10.2
33 carpal tunnel syndrome 10.1
34 torticollis 10.1
35 cervical dystonia 10.1
36 respiratory failure 10.1
37 heart disease 10.1
38 pica disease 10.1
39 neurosarcoidosis 10.1
40 basilar artery insufficiency 10.1
41 periarthritis 10.1
42 spinal cord disease 10.1
43 peripheral nervous system disease 10.1
44 brown-sequard syndrome 10.1
45 anterior spinal artery syndrome 10.1
46 muscular atrophy 10.1
47 neuropathy 10.1
48 chronic pain 10.1
49 myoclonus 10.1
50 spinal cord injury 10.1

Graphical network of the top 20 diseases related to Spondylosis, Cervical:



Diseases related to Spondylosis, Cervical

Symptoms & Phenotypes for Spondylosis, Cervical

Human phenotypes related to Spondylosis, Cervical:

32
# Description HPO Frequency HPO Source Accession
1 osteoarthritis 32 HP:0002758
2 spondylolisthesis 32 HP:0003302
3 spina bifida occulta 32 HP:0003298
4 cervical spondylosis 32 HP:0008480
5 spondylolysis 32 HP:0003304

Symptoms via clinical synopsis from OMIM:

57
Joints:
osteoarthritis

Spine:
spondylolisthesis
spina bifida occulta
cervical spondylosis
spondylolysis
transitional lumbar-sacral vertebra

Clinical features from OMIM:

184300

Drugs & Therapeutics for Spondylosis, Cervical

Drugs for Spondylosis, Cervical (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Hormones Phase 4
4 Tranquilizing Agents Phase 4
5 Central Nervous System Depressants Phase 4
6 Anti-Anxiety Agents Phase 4
7 Psychotropic Drugs Phase 4
8 Anticonvulsants Phase 4
9 calcium channel blockers Phase 4
10 Calcium, Dietary Phase 4
11
Ibuprofen Approved Phase 2 15687-27-1 3672
12 Analgesics Phase 2
13 Peripheral Nervous System Agents Phase 2
14 Analgesics, Non-Narcotic Phase 2
15 Cyclooxygenase Inhibitors Phase 2
16 Narcotics Phase 2
17 Anti-Inflammatory Agents, Non-Steroidal Phase 2
18 Analgesics, Opioid Phase 2
19 Anti-Inflammatory Agents Phase 2
20 Antirheumatic Agents Phase 2
21
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
22
alemtuzumab Approved, Investigational 216503-57-0
23
Meloxicam Approved, Vet_approved 71125-38-7 5281106 54677470
24 Neurotransmitter Agents
25 Adrenergic alpha-2 Receptor Agonists
26 Adrenergic Agonists
27 Adrenergic alpha-Agonists
28 Adjuvants, Anesthesia
29 Anesthetics
30 Hypnotics and Sedatives
31 Adrenergic Agents
32 Antihypertensive Agents
33 Antineoplastic Agents, Immunological

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Open Labelled Study of Pregabalin in the Treatment of Neuropathic Pain in Cervical Myeloradiculopathy (Pregabalin and Radicular Pain Study (PARPS)) Completed NCT01061697 Phase 4 Pregabalin
2 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
3 The CSM Trial: A Multicenter Study Comparing Ventral to Dorsal Surgery for Cervical Spondylotic Myelopathy Completed NCT00506558 Phase 3
4 ASIA Motor, Functional and Health Related Quality of Life Outcome in Traumatic Central Cord Syndrome, a Prospective Randomized Study Unknown status NCT00475748 Phase 2
5 Effect of Conservative Treatment With Cervical Collar in Patients With Cervical Radiculopathy and Radicular Pain. A Randomized Controlled Study Completed NCT00395798 Phase 2
6 NGHIÊN CỨU NGẪU NHIÊN, MÙ ĐÔI, CÓ ĐỐI CHỨNG TRONG ĐIỀU TRỊ HỘI CHỨNG CỔ VAI CÁNH TAY CỦA VIÊN NANG CỨNG TD 0019 (A Randomized, Double Blind, Placebo Controlled, Parallel Group, Phase 3 Trial to Evaluate the Satety and Efficacy of Therapy With Hard Capsule TD0019 in Cervical Scapulohumeral Syndrome) Completed NCT03845959 Phase 2 TD0019 oral capsule;Placebo oral capsule
7 Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery Terminated NCT02276911 Phase 2 Ibuprofen
8 Study on the Early Warning and Treatment of Cervical Spondylosis of Cervical Type on Young People Based on the " Move Generate Yang " Theory Unknown status NCT02199405
9 Recovery Profiles After c Spine Surgery: With or Without Dexmedetomidine as an Anesthetic Adjuvant Unknown status NCT02819089 Dexmedetomidine
10 The Effects of Diabetes and Glycosylation Profile on Outcomes in the Surgical Treatment of Cervical Spondylosis Unknown status NCT02758899
11 Decompressive Cervical Surgery for Antihypertensive Effect in Patients With Cervical Spondylosis and Hypertension-A Cohort Study Unknown status NCT02016768
12 Balance Chiropractic Therapy for Cervical Spondylotic Radiculopathy: a Randomized Parallel-controlled Trial Unknown status NCT02705131
13 Structural Spinal Cord Integrity in Patients With Cervical Spondylosis in Relation to Clinical Status Completed NCT01243684
14 Yoga Chikitsa for Neck Pain Caused by Cervical Spondylosis: a Randomized Controlled Pilot Trial Completed NCT03526965 Usual care
15 The Effect of Nuchal Ligament Calcification on Cervical Function in Patients With Neck Pain Completed NCT02362555
16 Evaluation and Physical Therapy for Patients With Degenerated Cervical Spine Completed NCT00162890
17 White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord - Pilot Study Completed NCT00280306
18 The CX-DZ-Ⅱ Intelligent Electroacupuncture Instrument for Neck Pain Completed NCT03005301
19 Diffusion Tensor Imaging of the Brain and Cervical Spine: Evaluation of Reproducibility in Normal Subjects and Diagnostic Utility in Patients With Cervical Spondylotic Myelopathy Completed NCT01868958
20 PATIENT-REPORTED-OUTCOMES IN CHRONIC CERVICAL PAIN PATIENTS WITH ACCOMPANYING UPPER LIMB RADIATING PAIN (NEUROPATHIC COMPONENT) TREATED WITH PREGABALIN IN PRIMARY CARE SETTINGS Completed NCT02868359
21 Establishing the Pathophysiology of Primary Spinal Syringomyelia Completed NCT00011245
22 An Assessment of Surgical Techniques for Treating Cervical Spondylotic Myelopathy Completed NCT00285337
23 The Effect of Noxipoint™ Therapy Versus Physical Therapy With Transcutaneous Electrical Never Stimulation on Chronic Cervical Pain Completed NCT01844167
24 Predictive Value of Diffusion MRI in Cervical Spondylotic Myelopathy Recruiting NCT03296592
25 Predictors of Outcome and Natural History in Patients With Cervical Spondylotic Myelopathy Recruiting NCT02936245
26 A Comparison of Anterior and Posterior Procedures for the Surgical Management of Cervical Spondylotic Myelopathy: Prospective Randomized Clinical Trial Recruiting NCT00876603
27 FUSION EVALUATION AFTER ANTERIOR CERVICAL DISCECTOMY AND FUSION WITH STAND ALONE LOCKING CAGE WITH BLADE HRCC® Recruiting NCT03950349
28 A Multi-Center, Prospective, Single-Arm Study of Patients Undergoing a Two or Three Level ACDF Using ViviGen Cellular Bone Matrix in Conjunction With Cervical Allograft Spacers and DePuy Synthes Spine Anterior Cervical Plate Systems Active, not recruiting NCT02814825
29 Cervical Spondylotic Myelopathy Surgical Trial Active, not recruiting NCT02076113
30 Motor Evoked Potentials as a Biomarker in Alemtuzumab Treated Multiple Sclerosis Patients Active, not recruiting NCT02623946
31 Evaluation on Efficacy of Total Artificial Disc Replacement (TDR) of Cervical Spondylosis: a Cohort Prospective Follow-up for 5 Years Not yet recruiting NCT03364816
32 A Muti-Center Study Comparing 3 Procedures for Bi-level Cervical Spondylosis Not yet recruiting NCT03358225
33 Clinical and Radiological Outcomes of Posterior Cervical Fusion Supplemented With Interfacet Spacers Not yet recruiting NCT04041583
34 Collar Immobilization Following a Posterior Cervical Laminectomy and Fusion: A Randomized Controlled Trial Terminated NCT01383876
35 Evaluation of DTRAX Graft in Patients With Cervical Degenerative Disc Disease Withdrawn NCT01616719
36 Comparison of Outcomes After ACDF Using Allograft Fusion Versus PEEK Fusion: a Prospective Clinical Trial Withdrawn NCT03187171
37 Magnetic Resonance Imaging of the Spine Withdrawn NCT01382290

Search NIH Clinical Center for Spondylosis, Cervical

Genetic Tests for Spondylosis, Cervical

Anatomical Context for Spondylosis, Cervical

MalaCards organs/tissues related to Spondylosis, Cervical:

41
Spinal Cord, Bone, Brain, Cortex, Testes, Heart, Skin

Publications for Spondylosis, Cervical

Articles related to Spondylosis, Cervical:

(show top 50) (show all 1690)
# Title Authors PMID Year
1
A possible genetic factor in cervical spondylosis. 38 8
5782795 1969
2
Familial occurrence of lumbar spondylolysis and spondylolisthesis. 8
668183 1978
3
TNF-α induces apoptosis of human nucleus pulposus cells via activating the TRIM14/NF-κB signalling pathway. 38
31322007 2019
4
Clinical effectiveness and safety of acupotomy: An overview of systematic reviews. 38
31383431 2019
5
Chronic myelitis associated with zoster sine herpete: A case report. 38
31393366 2019
6
Neck disability in patients with cervical spondylosis is associated with altered brain functional connectivity. 38
31420276 2019
7
Acupotomy versus acupuncture for cervical spondylotic radiculopathy: protocol of a systematic review and meta-analysis. 38
31399459 2019
8
Effect and Safety of CX-DZ-II Intelligent Electroacupuncture Therapeutic Instrument for Neck Pain Caused by Cervical Spondylos: Study Protocol for A Randomized Controlled Trial. 38
31372917 2019
9
Adjacent segment motion following multi-level ACDF: a kinematic and clinical study in patients with zero-profile anchored spacer or plate. 38
31428860 2019
10
Reoperation rate after anterior cervical discectomy and fusion using standalone cages in degenerative disease: a study of 2078 cases. 38
31404654 2019
11
Comparison of radiographic parameters after anterior cervical discectomy and fusion with semiconstrained translational versus rotational plate systems. 38
31176235 2019
12
[In vivo measurement of three-dimensional motion of the upper cervical spine using CT three-dimensional reconstruction]. 38
31382726 2019
13
A novel hybrid endoscopic approach for anterior cervical discectomy and fusion, and a meta-analysis of the literature. 38
31349080 2019
14
MRI evidence of brain atrophy, white matter damage, and functional adaptive changes in patients with cervical spondylosis and prolonged spinal cord compression. 38
31350584 2019
15
Comparison of high-intensity laser therapy and combination of ultrasound treatment and transcutaneous nerve stimulation in patients with cervical spondylosis: a randomized controlled trial. 38
30443883 2019
16
Ergonomic Latex Pillows as a Part of a Multimodal Intervention or as an Adjunct to Rehabilitation Programs in Cervical Spondylosis: Are They Useful?: A Randomized Controlled Trial. 38
30741761 2019
17
[Correlation analysis between C 7 slope and cervical sagittal parameters in short segment anterior cervical discectomy with fusion]. 38
31298007 2019
18
Surgical outcomes for distal-type cervical spondylotic amyotrophy: a multicenter retrospective analysis of 43 cases. 38
31290024 2019
19
Radiological and Clinical Outcomes of Anterior Cervical Discectomy and Fusion in Elderly Patients: A Comparative Analysis of Young-Old Patients (Ages 65-74 Years) and Middle-Old Patients (Over 75 Years). 38
31284342 2019
20
Rate of Return to Military Active Duty After Single and 2-Level Anterior Cervical Discectomy and Fusion: A 4-Year Retrospective Review. 38
29889242 2019
21
The operative treatment of shoulder pain in patients with a concurrent diagnosis of cervical spondylosis and shoulder dysfunction. 38
31380474 2019
22
Spinal cord swelling in patients with cervical compression myelopathy. 38
31200693 2019
23
Carbon-fibre cage reconstruction in anterior cervical corpectomy for multilevel cervical spondylosis: mid-term outcomes. 38
31380479 2019
24
Distinguishing scrub typhus-related deltoid paralysis from cervical spondylosis in an elderly patient: a case report. 38
31154558 2019
25
Comparison of Anterior Cervical Decompression and Fusion versus Laminoplasty in the Treatment of Multilevel Cervical Spondylotic Myelopathy: A Meta-Analysis of Clinical and Radiological Outcomes. 38
31254693 2019
26
Cervical spondylotic myelopathy mimicking transverse myelitis. 38
30986646 2019
27
Pathological changes of cervical spinal canal in cervical spondylotic myelopathy: A retrospective study on 39 cases. 38
31039495 2019
28
Spinal Cord Perfusion MR Imaging Implicates Both Ischemia and Hypoxia in the Pathogenesis of Cervical Spondylosis. 38
31077900 2019
29
Quantifying cervical spondylosis: reliability testing of a coherent CT-based scoring system. 38
31146696 2019
30
Clinical effect observation of intravenous application of zoledronic acid in patients with cervical spondylosis and osteoporosis after anterior cervical discectomy and fusion: A randomized controlled study. 38
31079567 2019
31
Anterior neck soft tissue thickness for airway evaluation measured by MRI in patients with cervical spondylosis: prospective cohort study. 38
31147371 2019
32
Cervical spondylotic internal jugular venous compression syndrome. 38
31119898 2019
33
Comparison of the Biomechanical Changes After Percutaneous Full-Endoscopic Anterior Cervical Discectomy versus Posterior Cervical Foraminotomy at C5-C6: A Finite Element-Based Study. 38
31096026 2019
34
Esophagus type cervical spondylosis. 38
30981870 2019
35
Hemidiaphragmatic Paralysis Due to Cervical Spondylosis: A Case Report. 38
31435573 2019
36
Treatment experience for full-thickness wound dehiscence with cerebrospinal fluid leakage following posterior primary spine surgery: Three case reports. 38
30985675 2019
37
[Neuromuscular Anatomy Update: A Useful Tool for Differential Diagnosis between Cervical Spondylosis and Related Disorders]. 38
30827955 2019
38
[Preliminary analysis on X-ray in youth neck type of cervical spondylosis with upper crossed syndrome]. 38
30922003 2019
39
Spinal sagittal alignment and trapezoidal deformity in patients with degenerative cervical spondylolisthesis. 38
30899028 2019
40
Thoracic outlet syndrome in a postoperative cervical spondylotic myelopathy patient: A case report. 38
30882659 2019
41
[Management of Cervical Spondylosis by Neurologists]. 38
30827957 2019
42
Alterations in Cortical Thickness and Subcortical Volume are Associated With Neurological Symptoms and Neck Pain in Patients With Cervical Spondylosis. 38
29548020 2019
43
[Case control study on Zero-profile intervertebral fusion system and conventional cage-plate intervertebral fusion system for the treatment of multi-segment cervical spondylosis]. 38
30922001 2019
44
Difference of Dynamic Morphometric Changes Between in Patients with Ossification of Posterior Longitudinal Ligament and Patients with Cervical Spondylosis: Assessment by Cervical Dynamic Magnetic Resonance Imaging. 38
30528528 2019
45
Myelopathy due to human T-cell leukemia virus type-1 from the donor after ABO-incompatible liver transplantation. 38
31029562 2019
46
The prevalence and impact of cervical spine pathologies in patients with nasopharyngeal carcinoma. 38
30846176 2019
47
Biomechanical comparison of percutaneous posterior endoscopic cervical discectomy and anterior cervical decompression and fusion on the treatment of cervical spondylotic radiculopathy. 38
30832736 2019
48
Risk Factors for Cerebrospinal Fluid Leak Following Anterior Cervical Discectomy and Fusion. 38
30379657 2019
49
Expert's comment concerning Grand Rounds case entitled "Double crush syndrome caused by cervical spondylosis and vertebral artery loop" by Young Joon Rho et al. (Eur Spine J; 2017: doi:10.1007/s00586-017-5064-0). 38
30382425 2019
50
Flap Reconstruction for Esophageal Perforation Following Anterior Cervical Plate Fixation. 38
30820058 2019

Variations for Spondylosis, Cervical

Expression for Spondylosis, Cervical

Search GEO for disease gene expression data for Spondylosis, Cervical.

Pathways for Spondylosis, Cervical

GO Terms for Spondylosis, Cervical

Sources for Spondylosis, Cervical

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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