Aliases & Classifications for Spondylosis, Cervical

MalaCards integrated aliases for Spondylosis, Cervical:

Name: Spondylosis, Cervical 58
Cervical Spondylosis 17

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
spondylosis, cervical:
Inheritance autosomal dominant inheritance


Summaries for Spondylosis, Cervical

MalaCards based summary : Spondylosis, Cervical, also known as cervical spondylosis, is related to central cord syndrome and barre-lieou syndrome. The drugs Pregabalin and Calcium have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related phenotypes are osteoarthritis and spondylolisthesis

Description from OMIM: 184300

Related Diseases for Spondylosis, Cervical

Diseases related to Spondylosis, Cervical via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 central cord syndrome 11.6
2 barre-lieou syndrome 11.3
3 spondylosis 10.8
4 radiculopathy 10.3
5 vertebrobasilar insufficiency 10.2
6 vertebral artery insufficiency 10.2
7 multiple sclerosis 10.2
8 quadriplegia 10.2
9 ischemia 10.2
10 osteoporosis 10.1
11 bone mineral density quantitative trait locus 8 10.1
12 bone mineral density quantitative trait locus 15 10.1
13 arteriovenous fistula 10.1
14 osteoarthritis 10.1
15 exostosis 10.1
16 periarthritis 10.1
17 brown-sequard syndrome 10.1
18 myoclonus 10.1
19 spinal cord infarction 10.1
20 amyotrophic lateral sclerosis 1 9.9
21 carpal tunnel syndrome 9.9
22 lipomatosis, multiple 9.9
23 migraine with or without aura 1 9.9
24 rheumatoid arthritis 9.9
25 trigeminal neuralgia 9.9
26 hypervitaminosis a 9.9
27 aging 9.9
28 ossification of the posterior longitudinal ligament of spine 9.9
29 coronary heart disease 1 9.9
30 cavitary optic disc anomalies 9.9
31 mononeuropathy of the median nerve, mild 9.9
32 angina pectoris 9.9
33 arthritis 9.9
34 cerebral palsy 9.9
35 motor neuron disease 9.9
36 neuromyelitis optica 9.9
37 spinal cord injury 9.9
38 thrombosis 9.9
39 pleomorphic lipoma 9.9
40 heart disease 9.9
41 lateral sclerosis 9.9
42 myelitis 9.9
43 syringomyelia 9.9
44 intracranial embolism 9.9
45 copper deficiency myelopathy 9.9
46 peripheral nervous system disease 9.9
47 muscular atrophy 9.9
48 carotid artery occlusion 9.9
49 neuropathy 9.9
50 pathologic nystagmus 9.9

Graphical network of the top 20 diseases related to Spondylosis, Cervical:



Diseases related to Spondylosis, Cervical

Symptoms & Phenotypes for Spondylosis, Cervical

Human phenotypes related to Spondylosis, Cervical:

33
# Description HPO Frequency HPO Source Accession
1 osteoarthritis 33 HP:0002758
2 spondylolisthesis 33 HP:0003302
3 spina bifida occulta 33 HP:0003298
4 cervical spondylosis 33 HP:0008480
5 spondylolysis 33 HP:0003304

Symptoms via clinical synopsis from OMIM:

58
Joints:
osteoarthritis

Spine:
spondylolisthesis
spina bifida occulta
cervical spondylosis
spondylolysis
transitional lumbar-sacral vertebra

Clinical features from OMIM:

184300

Drugs & Therapeutics for Spondylosis, Cervical

Drugs for Spondylosis, Cervical (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Analgesics Phase 4,Phase 2,Not Applicable
4 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
5 Central Nervous System Depressants Phase 4,Not Applicable
6 Psychotropic Drugs Phase 4
7 Calcium, Dietary Phase 4
8 Tranquilizing Agents Phase 4
9 Anti-Anxiety Agents Phase 4
10 Hormones Phase 4
11 Anticonvulsants Phase 4
12 calcium channel blockers Phase 4
13
Ibuprofen Approved Phase 2 15687-27-1 3672
14 Analgesics, Non-Narcotic Phase 2,Not Applicable
15 Analgesics, Opioid Phase 2
16 Antirheumatic Agents Phase 2
17 Anti-Inflammatory Agents, Non-Steroidal Phase 2
18 Cyclooxygenase Inhibitors Phase 2
19 Narcotics Phase 2
20 Anti-Inflammatory Agents Phase 2
21
Dexmedetomidine Approved, Vet_approved Not Applicable 113775-47-6 5311068 68602
22
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
23
Isoflurane Approved, Vet_approved Not Applicable 26675-46-7 3763
24
Meloxicam Approved, Vet_approved 71125-38-7 54677470 5281106
25 Adrenergic alpha-Agonists Not Applicable
26 Adrenergic Agents Not Applicable
27 Neurotransmitter Agents Not Applicable
28 Hypnotics and Sedatives Not Applicable
29 Adrenergic Agonists Not Applicable
30 Adrenergic alpha-2 Receptor Agonists Not Applicable
31 Anesthetics Not Applicable
32 Adjuvants, Anesthesia Not Applicable
33 Antihypertensive Agents
34 Anesthetics, Intravenous Not Applicable
35 Anesthetics, General Not Applicable
36 Anesthetics, Inhalation Not Applicable

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Pregabalin and Radicular Pain Study (PARPS) Completed NCT01061697 Phase 4 Pregabalin
2 The CSM Trial: A Multicenter Study Comparing Ventral to Dorsal Surgery for Cervical Spondylotic Myelopathy Completed NCT00506558 Phase 3
3 Effect of Cervical Collar in Cervical Radicular Pain. Completed NCT00395798 Phase 2
4 Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery Terminated NCT02276911 Phase 2 Ibuprofen
5 Study on the Early Warning and Treatment of Cervical Spondylosis of Cervical Type on Young People Based on the " Move Generate Yang " Theory Unknown status NCT02199405 Not Applicable
6 Diabetes and Glycosylation in Cervical Spondylosis Unknown status NCT02758899
7 Recovery Profiles After c Spine Surgery: With or Without Dexmedetomidine as an Anesthetic Adjuvant Unknown status NCT02819089 Not Applicable Dexmedetomidine
8 Decompressive Cervical Surgery and Hypertension Unknown status NCT02016768
9 Baxter: Actifuse SHAPE vs DBX in ACC Unknown status NCT02005081 Not Applicable
10 Balance Chiropractic Therapy for Cervical Spondylotic Radiculopathy Unknown status NCT02705131 Not Applicable
11 A Magnetic Resonance Imaging Study of Patients With Cervical Spondylosis Completed NCT01243684 Not Applicable
12 Yoga Chikitsa for Neck Pain Caused by Cervical Spondylosis Completed NCT03526965 Not Applicable Usual care
13 DTI of the Brain and Cervical Spine: Evaluation in Normal Subjects and Patients With Cervical Spondylotic Myelopathy Completed NCT01868958
14 High-Resolution Diffusion Tensor Imaging (DTI) of the Cervical Spinal Cord in the Setting of Spinal Cord Injury (SCI) Completed NCT01407705
15 The CX-DZ-Ⅱ Intelligent Electroacupuncture Instrument for Neck Pain Completed NCT03005301 Not Applicable
16 The Effect of Nuchal Ligament Calcification on Cervical Function in Patients With Neck Pain Completed NCT02362555
17 Evaluation and Physical Therapy for Patients With Degenerated Cervical Spine Completed NCT00162890
18 Study and Surgical Treatment of Syringomyelia Completed NCT00011245
19 Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly Completed NCT00788008 Not Applicable inhalation anesthesia with isoflurane vs. TIVA with propofol
20 Assessment of Surgical Techniques for Treating Cervical Spondylotic Myelopathy Completed NCT00285337
21 Predictors of Outcome and Natural History in Patients With Cervical Spondylotic Myelopathy Recruiting NCT02936245
22 FUSION EVALUATION AFTER ANTERIOR CERVICAL DISCECTOMY AND FUSION WITH STAND ALONE LOCKING CAGE WITH BLADE HRCC® Recruiting NCT03950349
23 ViBone in Cervical and Lumbar Spine Fusion Recruiting NCT03425682
24 Cervical Spondylotic Myelopathy Surgical Trial Active, not recruiting NCT02076113 Not Applicable
25 An ACDF Multi-Center Study Using ViviGen Cellular Bone Matrix Active, not recruiting NCT02814825
26 A Muti-Center Study Comparing 3 Procedures for Bi-level Cervical Spondylosis Not yet recruiting NCT03358225
27 Evaluation on Efficacy of Total Artificial Disc Replacement (TDR) of Cervical Spondylosis Not yet recruiting NCT03364816
28 Enhancing Recovery in Non-Traumatic Spinal Cord Injury Not yet recruiting NCT03320759 Not Applicable
29 Collar Immobilization Following a Posterior Cervical Laminectomy and Fusion Terminated NCT01383876 Not Applicable
30 Evaluation of DTRAX Graft in Patients With Cervical Degenerative Disc Disease Withdrawn NCT01616719 Not Applicable
31 ACDF Comparison Trial Withdrawn NCT03187171 Not Applicable

Search NIH Clinical Center for Spondylosis, Cervical

Genetic Tests for Spondylosis, Cervical

Anatomical Context for Spondylosis, Cervical

MalaCards organs/tissues related to Spondylosis, Cervical:

42
Spinal Cord, Bone, Brain, Heart, Cortex, Testes

Publications for Spondylosis, Cervical

Articles related to Spondylosis, Cervical:

(show top 50) (show all 546)
# Title Authors Year
1
Spinal cord perfusion MR imaging implicates both ischemia and hypoxia in the pathogenesis of cervical spondylosis. ( 31077900 )
2019
2
Clinical effect observation of intravenous application of zoledronic acid in patients with cervical spondylosis and osteoporosis after anterior cervical discectomy and fusion: A randomized controlled study. ( 31079567 )
2019
3
Double crush syndrome caused by cervical spondylosis and vertebral artery loop. ( 28508239 )
2019
4
Alterations in Cortical Thickness and Subcortical Volume are Associated With Neurological Symptoms and Neck Pain in Patients With Cervical Spondylosis. ( 29548020 )
2019
5
Expert's comment concerning Grand Rounds case entitled "Double crush syndrome caused by cervical spondylosis and vertebral artery loop" by Young Joon Rho et al. (Eur Spine J; 2017: doi:10.1007/s00586-017-5064-0). ( 30382425 )
2019
6
Ergonomic latex pillows as a part of a multimodal intervention or as an adjunct to rehabilitation programs in cervical spondylosis: Is it useful? A randomized controlled trial. ( 30741761 )
2019
7
Correlation of cervical and thoracic inlet sagittal parameters by MRI and radiography in patients with cervical spondylosis. ( 30762740 )
2019
8
Esophagus type cervical spondylosis. ( 30981870 )
2019
9
Laminoplasty for Cervical Spinal Cord Stimulator Implantation in Patients With Cervical Spondylosis and Fusion: A Technical Note. ( 30983900 )
2019
10
Clinical effects of the bridge-type ROI-C interbody fusion cage system in the treatment of cervical spondylosis with osteoporosis. ( 30587947 )
2018
11
Apparent C8-T1 radiculopathy with hand weakness due to mid-cervical spondylosis. ( 29097135 )
2018
12
Comparison between zero-profile spacer and plate with cage in the treatment of single level cervical spondylosis. ( 29171978 )
2018
13
Exploration about changes of IL-10, NF-κB and MMP-3 in a rat model of cervical spondylosis. ( 29197741 )
2018
14
The effectiveness of anterior cervical decompression and fusion for the relief of dizziness in patients with cervical spondylosis: a multicentre prospective cohort study. ( 29305455 )
2018
15
Wet Cupping Therapy Improves Local Blood Perfusion and Analgesic Effects in Patients with Nerve-Root Type Cervical Spondylosis. ( 29340888 )
2018
16
Changes and significance of inflammatory cytokines in a rat model of cervical spondylosis. ( 29387194 )
2018
17
Radiologic indicators for prediction of difficult laryngoscopy in patients with cervical spondylosis. ( 29388207 )
2018
18
Risk factors for non-fusion segment disease after anterior cervical spondylosis surgery: a retrospective study with long-term follow-up of 171 patients. ( 29394936 )
2018
19
Prevalence of and risk factors for Modic change in patients with symptomatic cervical spondylosis: an observational study. ( 29491718 )
2018
20
Risk of acute coronary syndrome in patients with cervical spondylosis. ( 29518745 )
2018
21
Comparison of sagittal parameters for anterior cervical discectomy and fusion, hybrid surgery, and total disc replacement for three levels of cervical spondylosis. ( 29550690 )
2018
22
Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study. ( 29587400 )
2018
23
What is the superior surgical strategy for bi-level cervical spondylosis-anterior cervical disc replacement or anterior cervical decompression and fusion?: A meta-analysis from 11 studies. ( 29595628 )
2018
24
Modified Laminoplasty for Degenerative Cervical Spondylosis: The Technique of Floating Laminoplasty. ( 29643725 )
2018
25
Reply to "Use of radiologic indicators to predict difficult laryngoscopy in patients with cervical spondylosis". ( 29675834 )
2018
26
Use of radiological indicators to predict difficult laryngoscopy in patients with cervical spondylosis. ( 29708587 )
2018
27
Ossification of posterior longitudinal ligament and cervical spondylosis: Same cause - Same treatment. ( 29755229 )
2018
28
Atypical symptoms in patients with cervical spondylosis: Comparison of the treatment effect of different surgical approaches. ( 29768345 )
2018
29
Effectiveness of percutaneous neuromuscular electrical stimulation for neck pain relief in patients with cervical spondylosis. ( 29952946 )
2018
30
Resting-State Functional Magnetic Resonance Imaging Connectivity of the Brain Is Associated with Altered Sensorimotor Function in Patients with Cervical Spondylosis. ( 30092474 )
2018
31
Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study. ( 30142924 )
2018
32
Risk of posterior circulation stroke in patients with cervical spondylosis: A nationwide, population-based study. ( 30172083 )
2018
33
Clinical efficacy of glucosamine hydrochloride tablets in the treatment of cervical spondylosis. ( 30203748 )
2018
34
Clinical effect of cervical paravertebral nerve block combined with Mailuoning and Angelica sinensis in treatment of nerve-root type cervical spondylosis. ( 30203752 )
2018
35
The prevalence and associated factors of symptomatic cervical Spondylosis in Chinese adults: a community-based cross-sectional study. ( 30205836 )
2018
36
Cervical instability in cervical spondylosis patients : Significance of the radiographic index method for evaluation. ( 30255359 )
2018
37
Motor neurone disease-associated neck pain misdiagnosed as cervical spondylosis: A case report and literature review. ( 30257805 )
2018
38
Association of Depression and Cervical Spondylosis: A Nationwide Retrospective Propensity Score-Matched Cohort Study. ( 30366474 )
2018
39
Comparison of high-intensity laser therapy and combination of ultrasound treatment and transcutaneous nerve stimulation in patients with cervical spondylosis: a randomized controlled trial. ( 30443883 )
2018
40
A Convenient Non-harm Cervical Spondylosis Intelligent Identity method based on Machine Learning. ( 30479349 )
2018
41
Difference of Dynamic Morphometric Changes Between in Patients with Ossification of Posterior Longitudinal Ligament and Patients with Cervical Spondylosis: Assessment by Cervical Dynamic Magnetic Resonance Imaging. ( 30528528 )
2018
42
The Option of Motion Preservation in Cervical Spondylosis: Cervical Disc Arthroplasty Update. ( 30545210 )
2018
43
Role of hybrid construct in cervical spondylosis. ( 30545645 )
2018
44
Regional Homogeneity and Multivariate Pattern Analysis of Cervical Spondylosis Neck Pain and the Modulation Effect of Treatment. ( 30574062 )
2018
45
A preliminary study: The effect of ergonomic latex pillow on pain and disability in patients with cervical spondylosis. ( 30643756 )
2018
46
Patients' beliefs about diagnosis and treatment of cervical spondylosis with radiculopathy. ( 29063271 )
2017
47
Neck circumference to inter-incisor gap ratio: a new predictor of difficult laryngoscopy in cervical spondylosis patients. ( 28376741 )
2017
48
Abnormal central motor conduction at the upper but not lower limbs correlates with severe cervical spondylosis: discussion of an unexpected observation. ( 28382220 )
2017
49
Complications and Mortality Following One to Two-Level Anterior Cervical Fusion for Cervical Spondylosis in Patients Above 80 Years of Age. ( 28441681 )
2017
50
Safety and Efficacy Study of an Ozone Laser Combined Therapy Using Puncture Needle in the Treatment of Patients With Cervical Spondylosis. ( 28525469 )
2017

Variations for Spondylosis, Cervical

Expression for Spondylosis, Cervical

Search GEO for disease gene expression data for Spondylosis, Cervical.

Pathways for Spondylosis, Cervical

GO Terms for Spondylosis, Cervical

Sources for Spondylosis, Cervical

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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