MCID: SPN011
MIFTS: 31

Spongiotic Dermatitis

Categories: Skin diseases

Aliases & Classifications for Spongiotic Dermatitis

MalaCards integrated aliases for Spongiotic Dermatitis:

Name: Spongiotic Dermatitis 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4406
NCIt 50 C27037
SNOMED-CT 67 23615008
UMLS 70 C0262984

Summaries for Spongiotic Dermatitis

MalaCards based summary : Spongiotic Dermatitis is related to pityriasis rosea and variola major. An important gene associated with Spongiotic Dermatitis is ITGB7 (Integrin Subunit Beta 7), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include t cells, skin and endothelial.

Related Diseases for Spongiotic Dermatitis

Diseases related to Spongiotic Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 pityriasis rosea 30.7 CD1E CD1A
2 variola major 30.3 CD8A CD4
3 seborrheic dermatitis 29.7 CD4 CD1E CD1C CD1B CD1A
4 dermatitis 10.5
5 predominantly cortical thymoma 10.3 CD1E CD1A
6 tolosa-hunt syndrome 10.3 CD1E CD1A
7 multifocal motor neuropathy 10.3 CD1E CD1A
8 kimura disease 10.3 CD1E CD1A
9 mycosis fungoides 10.3
10 juvenile xanthogranuloma 10.3 CD1E CD1A
11 tuberculoid leprosy 10.2 CD4 CD1B
12 cork-handlers' disease 10.2 CD8A CD4
13 necrotic uveal melanoma 10.2 CD8A CD4
14 early yaws 10.2 CD8A CD4
15 ventilation pneumonitis 10.2 CD8A CD4
16 diffuse infiltrative lymphocytosis syndrome 10.2 CD8A CD4
17 latent syphilis 10.2 CD8A CD4
18 type 1 diabetes mellitus 23 10.2 CD8A CD4
19 autoimmune lymphoproliferative syndrome, type iia 10.2 CD8A CD4
20 gastroduodenitis 10.2 CD8A CD4
21 duodenitis 10.2 CD8A CD4
22 primary syphilis 10.2 CD8A CD4
23 norwegian scabies 10.2 CD8A CD4
24 bird fancier's lung 10.2 CD8A CD4
25 metal allergy 10.2 CD8A CD4
26 tertiary syphilis 10.2 CD8A CD4
27 acute retinal necrosis syndrome 10.2 CD8A CD4
28 cerebral lymphoma 10.2 CD8A CD4
29 oral tuberculosis 10.2 CD8A CD4
30 cerebritis 10.2 CD8A CD4
31 invasive malignant thymoma 10.2 CD8A CD4
32 west nile encephalitis 10.2 CD8A CD4
33 granulomatous hepatitis 10.2 CD8A CD4
34 exanthema subitum 10.2 CD8A CD4
35 immunodeficiency 36 10.2 CD8A CD4
36 viral exanthem 10.2 CD8A CD4
37 secondary syphilis 10.2 CD8A CD4
38 glanders 10.2 CD8A CD4
39 superficial basal cell carcinoma 10.2 CD8A CD4
40 esophageal candidiasis 10.2 CD8A CD4
41 parotid disease 10.2 CD8A CD4
42 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.2 CD8A CD4
43 ulcerative stomatitis 10.2 CD8A CD4
44 west nile fever 10.2 CD8A CD4
45 neurosarcoidosis 10.2 CD8A CD4
46 retinitis pigmentosa 46 10.2 CD8A CD4
47 pneumonic tularemia 10.2 CD8A CD4
48 tularemia 10.2 CD8A CD4
49 farmer's lung 10.2 CD8A CD4
50 uveoparotid fever 10.2 CD8A CD4

Graphical network of the top 20 diseases related to Spongiotic Dermatitis:



Diseases related to Spongiotic Dermatitis

Symptoms & Phenotypes for Spongiotic Dermatitis

Drugs & Therapeutics for Spongiotic Dermatitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Molecular and Cellular Characterization of Spongiotic Dermatitis Completed NCT00371163

Search NIH Clinical Center for Spongiotic Dermatitis

Genetic Tests for Spongiotic Dermatitis

Anatomical Context for Spongiotic Dermatitis

MalaCards organs/tissues related to Spongiotic Dermatitis:

40
T Cells, Skin, Endothelial

Publications for Spongiotic Dermatitis

Articles related to Spongiotic Dermatitis:

(show top 50) (show all 175)
# Title Authors PMID Year
1
Increased MxA protein expression and dendritic cells in spongiotic dermatitis differentiates dermatomyositis from eczema in a single-center case-control study. 61
32954523 2021
2
[Report of the first case of tinea corporis bullosa by Trichophyton tonsurans]. 61
32820362 2021
3
Apalutamide-induced exanthematous drug eruption displaying spongiotic dermatitis successfully treated with dose reduction. 61
33559145 2021
4
Comparison of p53 immunohistochemical staining in differentiated vulvar intraepithelial neoplasia (dVIN) with that in inflammatory dermatoses and benign squamous lesions in the vulva. 61
32799363 2021
5
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema. 61
32618703 2021
6
Histopathological evaluation of cutaneous reactions to tattoos: Study at a tertiary care center. 61
33527478 2021
7
Eczematous graft-vs-host disease: A report of three cases and review of the literature. 61
32767402 2020
8
Widespread pustular eruption following probiotic use. 61
33342179 2020
9
Blaschkolinear Acquired Inflammatory Skin Eruption (BLAISE): Case Report of a Young Man Whose Dermatosis had Features of Lichen Striatus and Blaschkitis. 61
33154852 2020
10
Tinea Corporis Masquerading as a Diffuse Gyrate Erythema: Case Report and a Review of Annular Lesions Mimicking a Dermatophyte Skin Infection. 61
32760635 2020
11
Spongiform pemphigoid: A case series of an uncommon histopathologic pattern. 61
31837162 2020
12
Histopathological Study of Skin Lesions in a Tertiary Care Hospital: A Descriptive Cross-sectional Study. 61
32417857 2020
13
Diagnoses of hospitalized patients with skin abnormalities prompting biopsy by consulting dermatologists: A 3-year review from a tertiary care center. 61
31845375 2020
14
A Rare Case of Lichen Planus-Like Atopic Dermatitis Involving the Hands. 61
31855583 2020
15
Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor-associated dermatitis. 61
31859047 2020
16
Necrotic Keratinocytes Are Common in Psoriasis and Have a Predilection to the Upper Epidermis: A Quantitative and Comparative Analysis. 61
31094719 2020
17
Nummular dermatitis on guselkumab for palmoplantar psoriasis. 61
31070862 2019
18
Cutaneous T-Cell Acute Lymphoblastic Leukemia and the Expression Pattern of Terminal Deoxynucleotidyl Transferase Immunostaining in Mycosis Fungoides and Spongiotic Dermatitis. 61
31616658 2019
19
Case series of unique adverse events related to the use of ibrutinib in patients with B-cell malignancies-A single institution experience and a review of literature. 61
30045682 2019
20
A Case of Dermatitis Herpetiformis With Fibrillar Immunoglobulin A Deposition: A Rare Pattern Not to Be Missed. 61
30839342 2019
21
How useful is periodic acid-Schiff stain to detect fungi in biopsies from dermatoses of the palms and soles? 61
30843246 2019
22
Dendritic cell distribution in mycosis fungoides vs. inflammatory dermatosis and other T-cell skin lymphoma. 61
30944598 2019
23
Diagnosing Pemphigus Foliaceus: A Rare Blistering Disease Masquerading as a Common Dermatologic Disorder. 61
30215775 2019
24
Psoriasiform spongiotic dermatitis. 61
30850572 2019
25
Summer-Associated Dermatitis: A Cross-Sectional Study of a Unique Eczematous Dermatosis in South India. 61
30983610 2019
26
Pustular DRESS Syndrome Secondary to Hydroxychloroquine With EBV Reactivation 61
30811149 2019
27
Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis. 61
30510068 2019
28
Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: A retrospective case-control study. 61
29857011 2018
29
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy. 61
29256113 2018
30
Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics. 61
29143979 2018
31
Efficacy of Triaging Direct Immunofluorescence in Intraepidermal Bullous Dermatoses. 61
28368874 2018
32
A diagnostic checklist for generalized dermatitis. 61
30464569 2018
33
Recurrence of cutaneous coccidioidomycosis 6 years after valley fever: A case presentation and literature review. 61
28811115 2017
34
Feasibility study in teledermatopathology: An examination of the histopathologic features of mycosis fungoides and spongiotic dermatitis. 61
28796294 2017
35
Diagnostic Utility and Pitfalls of Tzanck Smear Cytology in Diagnosis of Various Cutaneous Lesions. 61
29118470 2017
36
The role of histological presentation in erythroderma. 61
28191631 2017
37
Idelalisib-induced colitis and skin eruption mimicking graft-versus-host disease. 61
28025783 2017
38
Chemical Tattoo Treatment Leading to Systemic Cobalt Hypersensitivity. 61
28705288 2017
39
Cutaneous metastasis of inflammatory breast carcinoma mimicking an erythema annulare centrifugum: a sign of locally recurrent cancer. 61
27766674 2016
40
Histopathologic spectrum of hypersensitivity reactions associated with anti-CD52 therapy (alemtuzumab). 61
27531597 2016
41
Cutaneous manifestations in inflammatory bowel disease: a single institutional study of non-neoplastic biopsies over 13 years. 61
27494987 2016
42
Reflectance Confocal Microscopy for Inflammatory Skin Diseases. 61
26996333 2016
43
Langerhans cell collections, but not eosinophils, are clues to a diagnosis of allergic contact dermatitis in appropriate skin biopsies. 61
26990596 2016
44
A Case of Blaschkitis with Features of Both Lichenoid and Spongiotic Dermatitis. 61
27293278 2016
45
Expression of T-bet and GATA-3 in early mycosis fungoides and spongiotic dermatitis. 61
27085233 2016
46
Meyerson Phenomenon as a Component of Melanoma in situ. 61
27149137 2016
47
Spongiotic dermatitis with Langerhans cell microvesicles. 61
26469341 2016
48
High Frequency of Severe Telaprevir-associated Skin Eruptions in Clinical Practice. 61
26073421 2016
49
Diagnostic value of Tzanck smear in various erosive, vesicular, and bullous skin lesions. 61
26751561 2015
50
Mycosis fungoides with epidermal mucinosis: a variant of mycosis fungoides with a spongiosis-like pattern. 61
26009972 2015

Variations for Spongiotic Dermatitis

Expression for Spongiotic Dermatitis

Search GEO for disease gene expression data for Spongiotic Dermatitis.

Pathways for Spongiotic Dermatitis

GO Terms for Spongiotic Dermatitis

Cellular components related to Spongiotic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.73 CD8A CD4 CD1E CD1D CD1C CD1A
2 lysosome GO:0005764 9.62 CD1E CD1D CD1C CD1B
3 endosome GO:0005768 9.55 CD1E CD1D CD1C CD1B CD1A
4 endosome membrane GO:0010008 9.26 CD1D CD1C CD1B CD1A
5 external side of plasma membrane GO:0009897 9.17 CD8A CD4 CD1E CD1D CD1C CD1B

Biological processes related to Spongiotic Dermatitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 CD8A CD7 CD4 CD1E CD1D CD1C
2 adaptive immune response GO:0002250 9.95 CD8A CD7 CD4 CD1E CD1C CD1B
3 immune response GO:0006955 9.86 CD8A CD7 CD4 CD1E CD1D CD1C
4 regulation of immune response GO:0050776 9.8 ITGB7 CD8A CD1D CD1C CD1B CD1A
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.65 CD8A CD7 CD4
6 T cell activation GO:0042110 9.63 CD8A CD7 CD4
7 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
8 heterotypic cell-cell adhesion GO:0034113 9.49 ITGB7 CD1D
9 T cell selection GO:0045058 9.43 CD4 CD1D
10 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
11 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Spongiotic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Spongiotic Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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