MCID: SPN011
MIFTS: 30

Spongiotic Dermatitis

Categories: Skin diseases
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Aliases & Classifications for Spongiotic Dermatitis

MalaCards integrated aliases for Spongiotic Dermatitis:

Name: Spongiotic Dermatitis 11 14 16 71

Classifications:



External Ids:

Disease Ontology 11 DOID:4406
NCIt 49 C27037
SNOMED-CT 68 23615008
UMLS 71 C0262984

Summaries for Spongiotic Dermatitis

MalaCards based summary: Spongiotic Dermatitis is related to fungal infectious disease and pityriasis rosea. An important gene associated with Spongiotic Dermatitis is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include skin, t cells and breast.

Related Diseases for Spongiotic Dermatitis

Diseases related to Spongiotic Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 447)
# Related Disease Score Top Affiliating Genes
1 fungal infectious disease 30.7 CD8A CD4 CCR6
2 pityriasis rosea 30.5 CD8A CD4 CD1E
3 contact dermatitis 30.2 CD8A CD4 CCR6
4 allergic disease 30.2 CD8A CD4 CCR6
5 dermatitis, atopic 29.8 TNFRSF8 FLG2 CD8A CD4 CCR6
6 mycosis fungoides 29.7 TNFRSF8 CD7 CD1C CD1B CD1A CCR6
7 leukemia, acute lymphoblastic 29.4 CD8A CD7 CD5 CD4 CCR6
8 primary cutaneous t-cell non-hodgkin lymphoma 29.3 TNFRSF8 CD7 CD5 CD4 CCR6
9 t-cell acute lymphoblastic leukemia 29.0 TNFRSF8 CD8A CD7 CD5 CD4 CCR6
10 seborrheic dermatitis 28.6 DSG1 CD4 CD1E CD1D CD1C CD1B
11 skin disease 27.7 TNFRSF8 DSG1 CD8A CD7 CD4 CD1E
12 dermatitis 10.6
13 duodenitis 10.3 CD8A CD4
14 tenosynovitis 10.3 CD8A CD4
15 hilar lung neoplasm 10.3 CD8A CD4
16 chancroid 10.3 CD4 CCR6
17 lobomycosis 10.3 CD4 CD1E
18 anti-basement membrane glomerulonephritis 10.3 CD4 CCR6
19 mikulicz disease 10.3 CD4 CCR6
20 oral tuberculosis 10.3 CD8A CD4
21 early yaws 10.3 CD8A CD4
22 b-lymphoblastic leukemia/lymphoma with hypodiploidy 10.3 CD7 CD1E
23 ventilation pneumonitis 10.3 CD8A CD4
24 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
25 wissler-fanconi syndrome 10.3 CD8A CD4
26 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
27 encephalitozoonosis 10.3 CD8A CD4
28 type 1 diabetes mellitus 23 10.3 CD8A CD4
29 cork-handlers' disease 10.3 CD8A CD4
30 subcutaneous mycosis 10.3 CD4 CCR6
31 superficial mycosis 10.3 CD4 CCR6
32 suppurative lymphadenitis 10.3 CD8A CD4
33 bird fancier's lung 10.3 CD8A CD4
34 primary syphilis 10.3 CD8A CD4
35 granulomatous angiitis 10.3 CD8A CD4
36 thymic dysplasia 10.3 CD8A CD4
37 tinea pedis 10.3 CD4 CCR6
38 splenic abscess 10.3 CD8A CD4
39 mooren's ulcer 10.3 CD8A CD4
40 herpes simplex virus keratitis 10.3 CD8A CD4
41 acute retinal necrosis syndrome 10.3 CD8A CD4
42 granulomatous hepatitis 10.3 CD8A CD4
43 norwegian scabies 10.3 CD8A CD4
44 orbital cellulitis 10.3 CD8A CD4
45 acute orbital inflammation 10.3 CD8A CD4
46 aortitis 10.3 CD4 CCR6
47 blastomycosis 10.3 CD4 CCR6
48 inflamed seborrheic keratosis 10.3 CD1E CD1A
49 viral exanthem 10.3 CD8A CD4
50 sympathetic ophthalmia 10.3 CD4 CCR6

Graphical network of the top 20 diseases related to Spongiotic Dermatitis:



Diseases related to Spongiotic Dermatitis

Symptoms & Phenotypes for Spongiotic Dermatitis

Drugs & Therapeutics for Spongiotic Dermatitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Molecular and Cellular Characterization of Spongiotic Dermatitis Completed NCT00371163

Search NIH Clinical Center for Spongiotic Dermatitis

Genetic Tests for Spongiotic Dermatitis

Anatomical Context for Spongiotic Dermatitis

Organs/tissues related to Spongiotic Dermatitis:

MalaCards : Skin, T Cells, Breast, Endothelial

Publications for Spongiotic Dermatitis

Articles related to Spongiotic Dermatitis:

(show top 50) (show all 194)
# Title Authors PMID Year
1
MUM1/IRF4 is Highly Expressed in Dermatopathic Lymphadenopathy: Potential Utility in Diagnosis and Differential Diagnosis. 62
35877199 2022
2
Maculopapular Drug Eruption Caused by Apalutamide: Case Report and Review of the Literature. 62
34526471 2022
3
Tofacitinib in the treatment of refractory eczemas - a case series. 62
35642323 2022
4
A single dose of benzathine penicillin G as an effective treatment for malignant syphilis in an HIV-positive patient: a case report. 62
36149278 2022
5
Dipeptidyl peptidase-4 inhibitor-associated cutaneous eruptions: a retrospective observational study. 62
35187695 2022
6
Nivolumab Immunotherapy-Related Skin Reactions Detected on 18F-FDG PET/CT in Renal Cell Cancer. 62
35439194 2022
7
Erythema Multiforme: A Presentation of COVID-19 Pneumonia. 62
35974861 2022
8
Immunological Pathomechanisms of Spongiotic Dermatitis in Skin Lesions of Atopic Dermatitis. 62
35743125 2022
9
Cutaneous Adverse Reactions Associated with Monoclonal Antibodies Treatment in Multiple Sclerosis: Case Reports and Short Literature Review. 62
35806991 2022
10
Spongiotic Pattern in Pemphigus: A Retrospective Observational Single-Center Study. 62
35645233 2022
11
Eczematous drug eruption in patients with psoriasis under anti-interleukin-17A: does interleukin-22 play a key role? 62
34862807 2022
12
Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review. 62
34423852 2022
13
Real-Time Reflectance Confocal Microscopy of Cutaneous Graft-versus-Host Disease Correlates with Histopathology. 62
34571213 2022
14
Clinical and pathologic correlation of cutaneous COVID-19 vaccine reactions including V-REPP: A registry-based study. 62
34517079 2022
15
Clinical and histopathological spectrum of delayed adverse cutaneous reactions following COVID-19 vaccination. 62
34292611 2022
16
Spongiotic reaction patterns in autoimmune bullous dermatoses (Review). 62
34630688 2021
17
Apalutamide-induced exanthematous drug eruption displaying spongiotic dermatitis successfully treated with dose reduction. 62
33559145 2021
18
Histopathological evaluation of cutaneous reactions to tattoos: Study at a tertiary care center. 62
33527478 2021
19
Radiation Recall Dermatitis in Patients Treated With Immune Checkpoint Inhibitors: A Case Report and Literature Review. 62
34277173 2021
20
Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation. 62
34045476 2021
21
Increased MxA protein expression and dendritic cells in spongiotic dermatitis differentiates dermatomyositis from eczema in a single-center case-control study. 62
32954523 2021
22
[Report of the first case of tinea corporis bullosa by Trichophyton tonsurans]. 62
32820362 2021
23
Comparison of p53 immunohistochemical staining in differentiated vulvar intraepithelial neoplasia (dVIN) with that in inflammatory dermatoses and benign squamous lesions in the vulva. 62
32799363 2021
24
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema. 62
32618703 2021
25
Clinical Patterns and Clinicopathologic Correlation of 100 Patients with Erythroderma in a Tertiary Care Institute in India. 62
35022116 2021
26
Eczematous graft-vs-host disease: A report of three cases and review of the literature. 62
32767402 2020
27
Widespread pustular eruption following probiotic use. 62
33342179 2020
28
Blaschkolinear Acquired Inflammatory Skin Eruption (BLAISE): Case Report of a Young Man Whose Dermatosis had Features of Lichen Striatus and Blaschkitis. 62
33154852 2020
29
Tinea Corporis Masquerading as a Diffuse Gyrate Erythema: Case Report and a Review of Annular Lesions Mimicking a Dermatophyte Skin Infection. 62
32760635 2020
30
Histopathological Study of Skin Lesions in a Tertiary Care Hospital: A Descriptive Cross-sectional Study. 62
32417857 2020
31
Diagnoses of hospitalized patients with skin abnormalities prompting biopsy by consulting dermatologists: A 3-year review from a tertiary care center. 62
31845375 2020
32
Spongiform pemphigoid: A case series of an uncommon histopathologic pattern. 62
31837162 2020
33
A Rare Case of Lichen Planus-Like Atopic Dermatitis Involving the Hands. 62
31855583 2020
34
Clinicopathologic overlap of psoriasis, eczema, and psoriasiform dermatoses: A retrospective study of T helper type 2 and 17 subsets, interleukin 36, and β-defensin 2 in spongiotic psoriasiform dermatitis, sebopsoriasis, and tumor necrosis factor α inhibitor-associated dermatitis. 62
31859047 2020
35
Necrotic Keratinocytes Are Common in Psoriasis and Have a Predilection to the Upper Epidermis: A Quantitative and Comparative Analysis. 62
31094719 2020
36
Nummular dermatitis on guselkumab for palmoplantar psoriasis. 62
31070862 2019
37
Case series of unique adverse events related to the use of ibrutinib in patients with B-cell malignancies-A single institution experience and a review of literature. 62
30045682 2019
38
Cutaneous T-Cell Acute Lymphoblastic Leukemia and the Expression Pattern of Terminal Deoxynucleotidyl Transferase Immunostaining in Mycosis Fungoides and Spongiotic Dermatitis. 62
31616658 2019
39
A Case of Dermatitis Herpetiformis With Fibrillar Immunoglobulin A Deposition: A Rare Pattern Not to Be Missed. 62
30839342 2019
40
How useful is periodic acid-Schiff stain to detect fungi in biopsies from dermatoses of the palms and soles? 62
30843246 2019
41
Dendritic cell distribution in mycosis fungoides vs. inflammatory dermatosis and other T-cell skin lymphoma. 62
30944598 2019
42
Diagnosing Pemphigus Foliaceus: A Rare Blistering Disease Masquerading as a Common Dermatologic Disorder. 62
30215775 2019
43
Psoriasiform spongiotic dermatitis. 62
30850572 2019
44
Summer-Associated Dermatitis: A Cross-Sectional Study of a Unique Eczematous Dermatosis in South India. 62
30983610 2019
45
Pustular DRESS Syndrome Secondary to Hydroxychloroquine With EBV Reactivation 62
30811149 2019
46
Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis. 62
30510068 2019
47
Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: A retrospective case-control study. 62
29857011 2018
48
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy. 62
29256113 2018
49
Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics. 62
29143979 2018
50
A diagnostic checklist for generalized dermatitis. 62
30464569 2018

Variations for Spongiotic Dermatitis

Expression for Spongiotic Dermatitis

Search GEO for disease gene expression data for Spongiotic Dermatitis.

Pathways for Spongiotic Dermatitis

GO Terms for Spongiotic Dermatitis

Cellular components related to Spongiotic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005887 10.59 CCR6 CD1A CD1C CD1D CD1E CD4
2 plasma membrane GO:0005886 10.59 CCR6 CD1A CD1B CD1C CD1D CD1E
3 membrane GO:0016021 10.07 CCR6 CD1A CD1B CD1C CD1D CD1E
4 membrane GO:0016020 10.07 CCR6 CD1A CD1B CD1C CD1D CD1E
5 endosome GO:0005768 9.65 CD1E CD1D CD1C CD1B CD1A
6 external side of plasma membrane GO:0009897 9.58 CD8A CD5 CD4 CD1E CD1D CD1C

Biological processes related to Spongiotic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.21 CD8A CD7 CD4 CD1E CD1C CD1B
2 immune response GO:0006955 10.03 CD8A CD7 CD4 CD1E CD1D CD1C
3 positive regulation of T cell mediated cytotoxicity GO:0001916 9.96 CD1A CD1B CD1C CD1D CD1E
4 immune system process GO:0002376 9.92 CD8A CD7 CD4 CD1E CD1D CD1C
5 T cell activation GO:0042110 9.91 CD8A CD7 CD4
6 T cell selection GO:0045058 9.71 CD4 CD1D
7 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.65 CD1E CD1D CD1C CD1B CD1A
8 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.32 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Spongiotic Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.86 CD7 CD5 CD4 CCR6
2 lipopeptide binding GO:0071723 9.85 CD1E CD1D CD1C CD1B CD1A
3 exogenous lipid antigen binding GO:0030884 9.65 CD1E CD1D CD1C CD1B CD1A
4 endogenous lipid antigen binding GO:0030883 9.32 CD1E CD1D CD1C CD1B CD1A

Sources for Spongiotic Dermatitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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