MCID: SPN340
MIFTS: 28

Spontaneous Intracranial Hypotension

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Spontaneous Intracranial Hypotension

MalaCards integrated aliases for Spontaneous Intracranial Hypotension:

Name: Spontaneous Intracranial Hypotension 59
Cerebrospinal Fluid Leak, Spontaneous 73
Spontaneous Cerebrospinal Fluid Leak 59
Intracranial Hypotension, Essential 73

Characteristics:

Orphanet epidemiological data:

59
spontaneous intracranial hypotension
Inheritance: Not applicable;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA443180
UMLS via Orphanet 74 C3544264 C3850067 C0751731
ICD10 via Orphanet 34 G96.0

Summaries for Spontaneous Intracranial Hypotension

MalaCards based summary : Spontaneous Intracranial Hypotension, also known as cerebrospinal fluid leak, spontaneous, is related to intracranial hypotension and headache. The drugs Fibrin Tissue Adhesive and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pituitary.

Wikipedia : 76 A spontaneous cerebrospinal fluid leak (SCSFL) is a medical condition in which the cerebrospinal fluid... more...

Related Diseases for Spontaneous Intracranial Hypotension

Diseases related to Spontaneous Intracranial Hypotension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 intracranial hypotension 11.1
2 headache 10.6
3 thrombosis 10.4
4 cerebritis 10.4
5 cerebrospinal fluid leak 10.3
6 cervicitis 10.2
7 thrombophilia due to thrombin defect 10.2
8 neuropathy 10.0
9 dementia 10.0
10 intracranial hypertension 10.0
11 meningitis 10.0
12 frontotemporal dementia with parkinsonism-17 10.0
13 aneurysm 10.0
14 frontotemporal dementia 10.0
15 tremor 10.0
16 stroke, ischemic 10.0
17 patulous eustachian tube 10.0
18 superficial siderosis 10.0
19 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
20 optic nerve disease 10.0
21 cranial nerve palsy 10.0
22 siderosis 10.0
23 thunderclap headache 10.0
24 marfan syndrome 9.9
25 movement disease 9.9
26 lupus erythematosus 9.7
27 anorexia nervosa 9.7
28 quadriplegia 9.7
29 autosomal dominant polycystic kidney disease 9.7
30 wegener granulomatosis 9.7
31 hyperprolactinemia 9.7
32 ehlers-danlos syndrome 9.7
33 hypoglycemia 9.7
34 bipolar disorder 9.7
35 polycystic kidney disease 9.7
36 abducens palsy 9.7
37 hydrocephalus 9.7
38 syringomyelia 9.7
39 multiple sclerosis 9.7
40 osteoarthritis 9.7
41 cough headache 9.7
42 systemic lupus erythematosus 9.7
43 sagittal sinus thrombosis 9.7
44 ependymoma 9.7
45 sensorineural hearing loss 9.7
46 tarlov cysts 9.7
47 scleroderma, familial progressive 9.7
48 pituitary adenoma 9.7
49 strabismus 9.7
50 acute cervicitis 9.7

Graphical network of the top 20 diseases related to Spontaneous Intracranial Hypotension:



Diseases related to Spontaneous Intracranial Hypotension

Symptoms & Phenotypes for Spontaneous Intracranial Hypotension

Drugs & Therapeutics for Spontaneous Intracranial Hypotension

Drugs for Spontaneous Intracranial Hypotension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrin Tissue Adhesive Phase 2
2 Coagulants Phase 2
3 Hemostatics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment Recruiting NCT03276975 Phase 2 TISSEEL
2 Spontaneous Intracranial Hypotension Treatment "SIHT" Recruiting NCT02261792 Not Applicable
3 Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension Recruiting NCT03041441 Not Applicable
4 Pituitary Function and Spontaneous Intracranial Hypotension Active, not recruiting NCT02603549

Search NIH Clinical Center for Spontaneous Intracranial Hypotension

Genetic Tests for Spontaneous Intracranial Hypotension

Anatomical Context for Spontaneous Intracranial Hypotension

MalaCards organs/tissues related to Spontaneous Intracranial Hypotension:

41
Brain, Spinal Cord, Pituitary, Kidney

Publications for Spontaneous Intracranial Hypotension

Articles related to Spontaneous Intracranial Hypotension:

(show top 50) (show all 453)
# Title Authors Year
1
Spontaneous intracranial hypotension complicated by cerebral venous thrombosis. ( 29955241 )
2018
2
Prevalence of hyperdense paraspinal vein sign in patients with spontaneous intracranial hypotension without dural CSF leak on standard CT myelography. ( 29217497 )
2018
3
Spontaneous intracranial hypotension with chronic brain sagging causing foramen magnum CSF circulation disorder reversible after lumbar epidural blood patch. ( 29441482 )
2018
4
New-onset headaches secondary to spontaneous intracranial hypotension. ( 29866680 )
2018
5
Distribution Patterns of Spinal Epidural Fluid in Patients with Spontaneous Intracranial Hypotension Syndrome. ( 29710056 )
2018
6
Acquired Chiari I Malformation Secondary to Spontaneous Intracranial Hypotension Syndrome and Persistent Hypoglycemia: A Case Report. ( 29513222 )
2018
7
Spontaneous Intracranial Hypotension as a Cause of Exacerbation in Huntington's Disease. ( 29756587 )
2018
8
Low tension of the dural sac as a cause of unsuccessful myelography in spontaneous intracranial hypotension: Evidence from computed tomographic-guided myelography. ( 29547178 )
2018
9
Targeted Epidural Blood Patch Treatment for Refractory Spontaneous Intracranial Hypotension in China. ( 29765818 )
2018
10
Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid. ( 29621631 )
2018
11
Spontaneous Intracranial Hypotension Induced Headaches and Onabotulinum Toxin A: A Case Report. ( 29103382 )
2018
12
Iatrogenic Development of Cerebrospinal Fluid Leakage in Diagnosing Spontaneous Intracranial Hypotension. ( 29629045 )
2018
13
Behavioral Variant Frontotemporal Dementia as a Serious Complication of Spontaneous Intracranial Hypotension. ( 29534203 )
2018
14
Spontaneous Intracranial Hypotension: 10 Myths and Misperceptions. ( 29797515 )
2018
15
Ossified ligamentum flavum of the thoracic spine presenting as spontaneous intracranial hypotension: case report. ( 29372863 )
2018
16
"Sinking into a coma" from spontaneous intracranial hypotension. ( 29653984 )
2018
17
Coma: A serious complication of spontaneous intracranial hypotension. ( 29653986 )
2018
18
Noninvasive assessment of intracranial elastance and pressure in spontaneous intracranial hypotension by MRI. ( 29437266 )
2018
19
Spontaneous Intracranial Hypotension Presenting as a "Pseudo-Chiari 1. ( 28357166 )
2017
20
Multilevel, ultra-large-volume epidural blood patch for the treatment of neurocognitive decline associated with spontaneous intracranial hypotension: case report. ( 28984516 )
2017
21
Factors predicting response to the first epidural blood patch in spontaneous intracranial hypotension. ( 28043956 )
2017
22
Spontaneous Intracranial Hypotension: A Review and Introduction of an Algorithm For Management. ( 28192268 )
2017
23
Spinal meningeal diverticula, spontaneous intracranial hypotension, and superficial siderosis. ( 28130464 )
2017
24
Intracranial structural alteration predicts treatment outcome in patients with spontaneous intracranial hypotension. ( 28110544 )
2017
25
Quantitative Measurement of CSF in Patients with Spontaneous Intracranial Hypotension. ( 28385881 )
2017
26
Spontaneous Intracranial Hypotension With Site of Leak Detected Only After 111In-DTPA Cisternogram. ( 28079571 )
2017
27
Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? ( 28679427 )
2017
28
Reversible Holmes' tremor due to spontaneous intracranial hypotension. ( 28754752 )
2017
29
Spontaneous intracranial hypotension diagnosed as Chiari I malformation. ( 28348118 )
2017
30
Spontaneous Intracranial Hypotension after Vestibular Schwannoma Resection Due to an Unexpected Pathology: Tarlov Cysts. ( 28652945 )
2017
31
Misdiagnosis of Spontaneous Intracranial Hypotension as a Risk Factor for Subdural Hematoma. ( 28653430 )
2017
32
Greater Occipital Nerve Treatment in the Management of Spontaneous Intracranial Hypotension Headache: A Case Report. ( 28466552 )
2017
33
Update on the Diagnosis and Treatment of Spontaneous Intracranial Hypotension. ( 28755201 )
2017
34
Simultaneous Surgical Decompression of Bilateral Subdural Hematoma and an Administration of Epidural Blood Patch for Spontaneous Intracranial Hypotension. ( 28538330 )
2017
35
Value of Targeted Epidural Blood Patch and Management of Subdural Hematoma in Spontaneous Intracranial Hypotension: Case Report and Review of the Literature. ( 27693247 )
2017
36
Treatment and outcome of subdural hematoma in patients with spontaneous intracranial hypotension: a report of 35 cases. ( 29052799 )
2017
37
CSF Venous Fistulas in Spontaneous Intracranial Hypotension: Imaging Characteristics on Dynamic and CT Myelography. ( 29023155 )
2017
38
Chiari-like displacement due to spontaneous intracranial hypotension in an adolescent: Successful treatment by epidural blood patch. ( 28283371 )
2017
39
Factors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension. ( 28681582 )
2017
40
Spontaneous Intracranial Hypotension. ( 28969244 )
2017
41
Successful Treatment of Spontaneous Intracranial Hypotension by Plugging the CSF Leak with Percutaneous Cyanoacrylate Injection: A Report of Two Cases. ( 27113404 )
2016
42
Patterns of cerebrospinal fluid (CSF) distribution in patients with spontaneous intracranial hypotension: Assessed with magnetic resonance myelography. ( 27743810 )
2016
43
Spontaneous Intracranial Hypotension Associated with Kinetic Tremor and Ataxia. ( 27351232 )
2016
44
Noncontrast Brain Computed Tomography Findings of Spontaneous Intracranial Hypotension in the Emergency Department Setting. ( 26763857 )
2016
45
Spontaneous intracranial hypotension syndrome: contribution of radioisotope cisternography. ( 27337940 )
2016
46
Spontaneous Intracranial Hypotension and its Association with Movement Disorders? ( 27897276 )
2016
47
Oculomotor Palsy in Spontaneous Intracranial Hypotension: Case Report and Review of the Literature. ( 27670216 )
2016
48
Iterative epidural blood patch for recurrent spontaneous intracranial hypotension during pregnancy. ( 27687382 )
2016
49
Time-Dependent Changes in Dural Enhancement Associated With Spontaneous Intracranial Hypotension. ( 27557149 )
2016
50
Application of time-spatial labeling inversion pulse magnetic resonance imaging in the diagnosis of spontaneous intracranial hypotension due to high-flow cerebrospinal fluid leakage at C1-2. ( 28144490 )
2016

Variations for Spontaneous Intracranial Hypotension

Expression for Spontaneous Intracranial Hypotension

Search GEO for disease gene expression data for Spontaneous Intracranial Hypotension.

Pathways for Spontaneous Intracranial Hypotension

GO Terms for Spontaneous Intracranial Hypotension

Sources for Spontaneous Intracranial Hypotension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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