MCID: SPN340
MIFTS: 28

Spontaneous Intracranial Hypotension

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Spontaneous Intracranial Hypotension

MalaCards integrated aliases for Spontaneous Intracranial Hypotension:

Name: Spontaneous Intracranial Hypotension 60
Cerebrospinal Fluid Leak, Spontaneous 74
Spontaneous Cerebrospinal Fluid Leak 60
Intracranial Hypotension, Essential 74

Characteristics:

Orphanet epidemiological data:

60
spontaneous intracranial hypotension
Inheritance: Not applicable;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 G96.0
UMLS via Orphanet 75 C0751731 C3544264 C3850067
Orphanet 60 ORPHA443180

Summaries for Spontaneous Intracranial Hypotension

MalaCards based summary : Spontaneous Intracranial Hypotension, also known as cerebrospinal fluid leak, spontaneous, is related to intracranial hypotension and headache. An important gene associated with Spontaneous Intracranial Hypotension is PTGDS (Prostaglandin D2 Synthase). Affiliated tissues include brain, spinal cord and pituitary.

Wikipedia : 77 A spontaneous cerebrospinal fluid leak (SCSFL) is a medical condition in which the cerebrospinal fluid... more...

Related Diseases for Spontaneous Intracranial Hypotension

Diseases related to Spontaneous Intracranial Hypotension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 intracranial hypotension 31.3 PTGDS TF
2 headache 10.7
3 thrombosis 10.5
4 cerebrospinal fluid leak 10.4
5 thrombophilia due to thrombin defect 10.4
6 frontotemporal dementia 10.2
7 dementia 10.2
8 siderosis 10.2
9 intracranial hypertension 10.2
10 superficial siderosis 10.2
11 marfan syndrome 10.1
12 stroke, ischemic 10.1
13 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
14 patulous eustachian tube 10.1
15 optic nerve disease 10.1
16 neuropathy 10.1
17 thunderclap headache 10.1
18 tremor 10.1
19 systemic lupus erythematosus 10.0
20 sagittal sinus thrombosis 10.0
21 cranial nerve palsy 10.0
22 movement disease 10.0
23 lupus erythematosus 10.0
24 body mass index quantitative trait locus 1 10.0
25 allergic rhinitis 10.0
26 rhinitis 10.0
27 abducens palsy 9.9
28 multiple sclerosis 9.9
29 scleroderma, familial progressive 9.9
30 strabismus 9.9
31 trigeminal neuralgia 9.9
32 vertigo, benign recurrent 9.9
33 chiari malformation type ii 9.9
34 ocular motor apraxia 9.9
35 anorexia nervosa 9.9
36 granulomatosis with polyangiitis 9.9
37 hyperprolactinemia 9.9
38 bipolar disorder 9.9
39 hydrocephalus 9.9
40 osteoarthritis 9.9
41 polycystic kidney disease 9.9
42 sensorineural hearing loss 9.9
43 abducens nerve disease 9.9
44 disseminated intravascular coagulation 9.9
45 aseptic meningitis 9.9
46 quadriplegia 9.9
47 ehlers-danlos syndrome 9.9
48 benign paroxysmal positional nystagmus 9.9
49 exostosis 9.9
50 syringomyelia 9.9

Graphical network of the top 20 diseases related to Spontaneous Intracranial Hypotension:



Diseases related to Spontaneous Intracranial Hypotension

Symptoms & Phenotypes for Spontaneous Intracranial Hypotension

Drugs & Therapeutics for Spontaneous Intracranial Hypotension

Search Clinical Trials , NIH Clinical Center for Spontaneous Intracranial Hypotension

Genetic Tests for Spontaneous Intracranial Hypotension

Anatomical Context for Spontaneous Intracranial Hypotension

MalaCards organs/tissues related to Spontaneous Intracranial Hypotension:

42
Brain, Spinal Cord, Pituitary, Bone, Kidney

Publications for Spontaneous Intracranial Hypotension

Articles related to Spontaneous Intracranial Hypotension:

(show top 50) (show all 570)
# Title Authors Year
1
Do Most Patients With a Spontaneous Cerebrospinal Fluid Leak Have Idiopathic Intracranial Hypertension? ( 30747786 )
2019
2
Lumbar epidural blood patch: effectiveness on orthostatic headache and MRI predictive factors in 101 consecutive patients affected by spontaneous intracranial hypotension. ( 30738382 )
2019
3
Reversible cerebellar herniation after epidural blood patch in a patient with spontaneous intracranial hypotension. ( 30522910 )
2019
4
Procedural predictors of epidural blood patch efficacy in spontaneous intracranial hypotension. ( 30636714 )
2019
5
Renal Contrast on CT Myelography: Diagnostic Value in Patients with Spontaneous Intracranial Hypotension. ( 30655256 )
2019
6
Spontaneous Intracranial Hypotension: Imaging in Diagnosis and Treatment. ( 30709479 )
2019
7
Intrathecal saline infusion as an effective temporizing measure in the management of spontaneous intracranial hypotension. ( 30716492 )
2019
8
Spontaneous intracranial hypotension associated with pachymeningeal enhancement in a patient with systemic lupus erythematosus (SLE): an extremely rare presenting feature. ( 30737326 )
2019
9
Assessing Spinal Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension With a Scoring System Based on Brain Magnetic Resonance Imaging Findings. ( 30776059 )
2019
10
MRI Findings of Spontaneous Intracranial Hypotension: Usefulness of Straight Sinus Distention. ( 30807225 )
2019
11
Decubitus CT Myelography for Detecting Subtle CSF Leaks in Spontaneous Intracranial Hypotension. ( 30819772 )
2019
12
A clinical analysis on 40 cases of spontaneous intracranial hypotension syndrome. ( 30870079 )
2019
13
A Review of Spontaneous Intracranial Hypotension. ( 30888542 )
2019
14
Neuraxial Anesthesia in a Patient With a History of Spontaneous Intracranial Hypotension: A Case Report. ( 30893062 )
2019
15
Spontaneous intracranial hypotension complicated by cerebral venous thrombosis. ( 29955241 )
2018
16
Prevalence of hyperdense paraspinal vein sign in patients with spontaneous intracranial hypotension without dural CSF leak on standard CT myelography. ( 29217497 )
2018
17
Spontaneous intracranial hypotension with chronic brain sagging causing foramen magnum CSF circulation disorder reversible after lumbar epidural blood patch. ( 29441482 )
2018
18
New-onset headaches secondary to spontaneous intracranial hypotension. ( 29866680 )
2018
19
Distribution Patterns of Spinal Epidural Fluid in Patients with Spontaneous Intracranial Hypotension Syndrome. ( 29710056 )
2018
20
Acquired Chiari I Malformation Secondary to Spontaneous Intracranial Hypotension Syndrome and Persistent Hypoglycemia: A Case Report. ( 29513222 )
2018
21
Spontaneous Intracranial Hypotension as a Cause of Exacerbation in Huntington's Disease. ( 29756587 )
2018
22
Low tension of the dural sac as a cause of unsuccessful myelography in spontaneous intracranial hypotension: Evidence from computed tomographic-guided myelography. ( 29547178 )
2018
23
Targeted Epidural Blood Patch Treatment for Refractory Spontaneous Intracranial Hypotension in China. ( 29765818 )
2018
24
Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid. ( 29621631 )
2018
25
Spontaneous Intracranial Hypotension Induced Headaches and Onabotulinum Toxin A: A Case Report. ( 29103382 )
2018
26
Iatrogenic Development of Cerebrospinal Fluid Leakage in Diagnosing Spontaneous Intracranial Hypotension. ( 29629045 )
2018
27
Behavioral Variant Frontotemporal Dementia as a Serious Complication of Spontaneous Intracranial Hypotension. ( 29534203 )
2018
28
Spontaneous Intracranial Hypotension: 10 Myths and Misperceptions. ( 29797515 )
2018
29
Ossified ligamentum flavum of the thoracic spine presenting as spontaneous intracranial hypotension: case report. ( 29372863 )
2018
30
"Sinking into a coma" from spontaneous intracranial hypotension. ( 29653984 )
2018
31
Coma: A serious complication of spontaneous intracranial hypotension. ( 29653986 )
2018
32
Noninvasive assessment of intracranial elastance and pressure in spontaneous intracranial hypotension by MRI. ( 29437266 )
2018
33
The Effect of lumbar drains on spontaneous cerebrospinal fluid leak repair. ( 30351284 )
2018
34
Spontaneous Intracranial Hypotension Presenting With Frontotemporal Dementia: A Case Report. ( 30174645 )
2018
35
Epidural blood patch treatment of diplopia that developed after headache resolution in a patient with spontaneous intracranial hypotension. ( 30186972 )
2018
36
Benign paroxysmal positional vertigo in spontaneous intracranial hypotension. ( 30052143 )
2018
37
Management of Presumed Spontaneous Intracranial Hypotension: A Case Report. ( 30052533 )
2018
38
Posterior Approach and Spinal Cord Release for 360° Repair of Dural Defects in Spontaneous Intracranial Hypotension. ( 30053151 )
2018
39
Percutaneous Epidural Hydrogel Sealant for the Treatment of Spontaneous Intracranial Hypotension: A Case Report of Chronic Thoracic Neuralgia and Technical Lessons Learned. ( 30057825 )
2018
40
Spontaneous intracranial hypotension due to sacral diverticula: Two-case history and a pocket-sized review. ( 30072229 )
2018
41
Sonography of the optic nerve sheath diameter before and after microsurgical closure of a dural CSF fistula in patients with spontaneous intracranial hypotension - a consecutive cohort study. ( 30099952 )
2018
42
Challenges in the Diagnosis and Treatment of Spontaneous Intracranial Hypotension. ( 30226451 )
2018
43
Cryptogenic Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension: Role of Dynamic CT Myelography. ( 30226459 )
2018
44
Spontaneous intracranial hypotension and its complications. ( 30231122 )
2018
45
Cerebral Venous Thrombosis in Spontaneous Intracranial Hypotension: A Report on 4 Cases and a Review of the Literature. ( 30238694 )
2018
46
Clinical effect of the proximity of epidural blood patch injection to the leakage site in spontaneous intracranial hypotension. ( 30282491 )
2018
47
Study of lamina cribrosa depth and optic nerve in patients with spontaneous intracranial hypotension. ( 30295059 )
2018
48
Correlations among brain and spinal MRI findings in spontaneous intracranial hypotension. ( 30301380 )
2018
49
Superior sagittal sinus thrombosis as a rare complication of spontaneous intracranial hypotension syndrome: a case report and review of the literature. ( 30345841 )
2018
50
Secondary Endolymphatic Hydrops Associated With Spontaneous Intracranial Hypotension. ( 30476972 )
2018

Variations for Spontaneous Intracranial Hypotension

Expression for Spontaneous Intracranial Hypotension

Search GEO for disease gene expression data for Spontaneous Intracranial Hypotension.

Pathways for Spontaneous Intracranial Hypotension

GO Terms for Spontaneous Intracranial Hypotension

Cellular components related to Spontaneous Intracranial Hypotension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.62 PTGDS TF

Sources for Spontaneous Intracranial Hypotension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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