MCID: SPN340
MIFTS: 32

Spontaneous Intracranial Hypotension

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Spontaneous Intracranial Hypotension

MalaCards integrated aliases for Spontaneous Intracranial Hypotension:

Name: Spontaneous Intracranial Hypotension 59
Cerebrospinal Fluid Leak, Spontaneous 73
Spontaneous Cerebrospinal Fluid Leak 59
Intracranial Hypotension, Essential 73

Characteristics:

Orphanet epidemiological data:

59
spontaneous intracranial hypotension
Inheritance: Not applicable;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA443180
UMLS via Orphanet 74 C3544264 C3850067 C0751731
ICD10 via Orphanet 34 G96.0

Summaries for Spontaneous Intracranial Hypotension

MalaCards based summary : Spontaneous Intracranial Hypotension, also known as cerebrospinal fluid leak, spontaneous, is related to intracranial hypotension and headache. An important gene associated with Spontaneous Intracranial Hypotension is TF (Transferrin). The drugs Hemostatics and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pituitary.

Wikipedia : 76 A spontaneous cerebrospinal fluid leak (SCSFL) is a medical condition in which the cerebrospinal fluid... more...

Related Diseases for Spontaneous Intracranial Hypotension

Diseases related to Spontaneous Intracranial Hypotension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 intracranial hypotension 31.5 PTGDS TF
2 headache 10.7
3 thrombosis 10.5
4 cerebrospinal fluid leak 10.4
5 thrombophilia due to thrombin defect 10.4
6 frontotemporal dementia 10.2
7 dementia 10.2
8 frontotemporal dementia with parkinsonism-17 10.2
9 siderosis 10.2
10 intracranial hypertension 10.2
11 superficial siderosis 10.2
12 marfan syndrome 10.1
13 stroke, ischemic 10.1
14 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
15 patulous eustachian tube 10.1
16 optic nerve disease 10.1
17 neuropathy 10.1
18 thunderclap headache 10.1
19 tremor 10.1
20 sagittal sinus thrombosis 10.0
21 cranial nerve palsy 10.0
22 movement disease 10.0
23 allergic rhinitis 10.0
24 rhinitis 10.0
25 abducens palsy 9.9
26 aortic valve disease 1 9.9
27 multiple sclerosis 9.9
28 systemic lupus erythematosus 9.9
29 scleroderma, familial progressive 9.9
30 strabismus 9.9
31 trigeminal neuralgia 9.9
32 vertigo, benign recurrent 9.9
33 chiari malformation type ii 9.9
34 anorexia nervosa 9.9
35 granulomatosis with polyangiitis 9.9
36 hyperprolactinemia 9.9
37 bipolar disorder 9.9
38 hydrocephalus 9.9
39 osteoarthritis 9.9
40 polycystic kidney disease 9.9
41 sensorineural hearing loss 9.9
42 abducens nerve disease 9.9
43 disseminated intravascular coagulation 9.9
44 aseptic meningitis 9.9
45 quadriplegia 9.9
46 ehlers-danlos syndrome 9.9
47 benign paroxysmal positional nystagmus 9.9
48 exostosis 9.9
49 syringomyelia 9.9
50 pituitary adenoma 9.9

Graphical network of the top 20 diseases related to Spontaneous Intracranial Hypotension:



Diseases related to Spontaneous Intracranial Hypotension

Symptoms & Phenotypes for Spontaneous Intracranial Hypotension

Drugs & Therapeutics for Spontaneous Intracranial Hypotension

Drugs for Spontaneous Intracranial Hypotension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hemostatics Phase 2
2 Coagulants Phase 2
3 Fibrin Tissue Adhesive Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment Recruiting NCT03276975 Phase 2 TISSEEL
2 Spontaneous Intracranial Hypotension Treatment "SIHT" Unknown status NCT02261792 Not Applicable
3 Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension Recruiting NCT03041441 Not Applicable
4 Pituitary Function and Spontaneous Intracranial Hypotension Active, not recruiting NCT02603549

Search NIH Clinical Center for Spontaneous Intracranial Hypotension

Genetic Tests for Spontaneous Intracranial Hypotension

Anatomical Context for Spontaneous Intracranial Hypotension

MalaCards organs/tissues related to Spontaneous Intracranial Hypotension:

41
Brain, Spinal Cord, Pituitary, Bone, Kidney

Publications for Spontaneous Intracranial Hypotension

Articles related to Spontaneous Intracranial Hypotension:

(show top 50) (show all 556)
# Title Authors Year
1
Spontaneous intracranial hypotension complicated by cerebral venous thrombosis. ( 29955241 )
2018
2
Prevalence of hyperdense paraspinal vein sign in patients with spontaneous intracranial hypotension without dural CSF leak on standard CT myelography. ( 29217497 )
2018
3
Spontaneous intracranial hypotension with chronic brain sagging causing foramen magnum CSF circulation disorder reversible after lumbar epidural blood patch. ( 29441482 )
2018
4
New-onset headaches secondary to spontaneous intracranial hypotension. ( 29866680 )
2018
5
Distribution Patterns of Spinal Epidural Fluid in Patients with Spontaneous Intracranial Hypotension Syndrome. ( 29710056 )
2018
6
Acquired Chiari I Malformation Secondary to Spontaneous Intracranial Hypotension Syndrome and Persistent Hypoglycemia: A Case Report. ( 29513222 )
2018
7
Spontaneous Intracranial Hypotension as a Cause of Exacerbation in Huntington's Disease. ( 29756587 )
2018
8
Low tension of the dural sac as a cause of unsuccessful myelography in spontaneous intracranial hypotension: Evidence from computed tomographic-guided myelography. ( 29547178 )
2018
9
Targeted Epidural Blood Patch Treatment for Refractory Spontaneous Intracranial Hypotension in China. ( 29765818 )
2018
10
Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid. ( 29621631 )
2018
11
Spontaneous Intracranial Hypotension Induced Headaches and Onabotulinum Toxin A: A Case Report. ( 29103382 )
2018
12
Iatrogenic Development of Cerebrospinal Fluid Leakage in Diagnosing Spontaneous Intracranial Hypotension. ( 29629045 )
2018
13
Behavioral Variant Frontotemporal Dementia as a Serious Complication of Spontaneous Intracranial Hypotension. ( 29534203 )
2018
14
Spontaneous Intracranial Hypotension: 10 Myths and Misperceptions. ( 29797515 )
2018
15
Ossified ligamentum flavum of the thoracic spine presenting as spontaneous intracranial hypotension: case report. ( 29372863 )
2018
16
"Sinking into a coma" from spontaneous intracranial hypotension. ( 29653984 )
2018
17
Coma: A serious complication of spontaneous intracranial hypotension. ( 29653986 )
2018
18
Noninvasive assessment of intracranial elastance and pressure in spontaneous intracranial hypotension by MRI. ( 29437266 )
2018
19
The Effect of lumbar drains on spontaneous cerebrospinal fluid leak repair. ( 30351284 )
2018
20
Spontaneous Intracranial Hypotension Presenting With Frontotemporal Dementia: A Case Report. ( 30174645 )
2018
21
Epidural blood patch treatment of diplopia that developed after headache resolution in a patient with spontaneous intracranial hypotension. ( 30186972 )
2018
22
Benign paroxysmal positional vertigo in spontaneous intracranial hypotension. ( 30052143 )
2018
23
Management of Presumed Spontaneous Intracranial Hypotension: A Case Report. ( 30052533 )
2018
24
Posterior Approach and Spinal Cord Release for 360° Repair of Dural Defects in Spontaneous Intracranial Hypotension. ( 30053151 )
2018
25
Percutaneous Epidural Hydrogel Sealant for the Treatment of Spontaneous Intracranial Hypotension: A Case Report of Chronic Thoracic Neuralgia and Technical Lessons Learned. ( 30057825 )
2018
26
Spontaneous intracranial hypotension due to sacral diverticula: Two-case history and a pocket-sized review. ( 30072229 )
2018
27
Sonography of the optic nerve sheath diameter before and after microsurgical closure of a dural CSF fistula in patients with spontaneous intracranial hypotension - a consecutive cohort study. ( 30099952 )
2018
28
Challenges in the Diagnosis and Treatment of Spontaneous Intracranial Hypotension. ( 30226451 )
2018
29
Cryptogenic Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension: Role of Dynamic CT Myelography. ( 30226459 )
2018
30
Spontaneous intracranial hypotension and its complications. ( 30231122 )
2018
31
Cerebral Venous Thrombosis in Spontaneous Intracranial Hypotension: A Report on 4 Cases and a Review of the Literature. ( 30238694 )
2018
32
Clinical effect of the proximity of epidural blood patch injection to the leakage site in spontaneous intracranial hypotension. ( 30282491 )
2018
33
Study of lamina cribrosa depth and optic nerve in patients with spontaneous intracranial hypotension. ( 30295059 )
2018
34
Correlations among brain and spinal MRI findings in spontaneous intracranial hypotension. ( 30301380 )
2018
35
Superior sagittal sinus thrombosis as a rare complication of spontaneous intracranial hypotension syndrome: a case report and review of the literature. ( 30345841 )
2018
36
Secondary Endolymphatic Hydrops Associated With Spontaneous Intracranial Hypotension. ( 30476972 )
2018
37
Letter to the Editor. Epidural blood patch in superficial siderosis caused by spontaneous intracranial hypotension. ( 30485219 )
2018
38
Two-site blind epidural blood patch versus targeted epidural blood patch in spontaneous intracranial hypotension. ( 30497854 )
2018
39
Reversible cerebellar herniation after epidural blood patch in a patient with spontaneous intracranial hypotension. ( 30522910 )
2018
40
Spontaneous Intracranial Hypotension Presenting as a "Pseudo-Chiari 1. ( 28357166 )
2017
41
Multilevel, ultra-large-volume epidural blood patch for the treatment of neurocognitive decline associated with spontaneous intracranial hypotension: case report. ( 28984516 )
2017
42
Factors predicting response to the first epidural blood patch in spontaneous intracranial hypotension. ( 28043956 )
2017
43
Spontaneous Intracranial Hypotension: A Review and Introduction of an Algorithm For Management. ( 28192268 )
2017
44
Spontaneous cerebrospinal fluid leak from the optic canal. ( 29276604 )
2017
45
Spinal meningeal diverticula, spontaneous intracranial hypotension, and superficial siderosis. ( 28130464 )
2017
46
Intracranial structural alteration predicts treatment outcome in patients with spontaneous intracranial hypotension. ( 28110544 )
2017
47
Quantitative Measurement of CSF in Patients with Spontaneous Intracranial Hypotension. ( 28385881 )
2017
48
Spontaneous Intracranial Hypotension With Site of Leak Detected Only After 111In-DTPA Cisternogram. ( 28079571 )
2017
49
Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? ( 28679427 )
2017
50
Reversible Holmes' tremor due to spontaneous intracranial hypotension. ( 28754752 )
2017

Variations for Spontaneous Intracranial Hypotension

Expression for Spontaneous Intracranial Hypotension

Search GEO for disease gene expression data for Spontaneous Intracranial Hypotension.

Pathways for Spontaneous Intracranial Hypotension

GO Terms for Spontaneous Intracranial Hypotension

Cellular components related to Spontaneous Intracranial Hypotension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.62 PTGDS TF

Sources for Spontaneous Intracranial Hypotension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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