MCID: SPN033
MIFTS: 27

Spontaneous Ocular Nystagmus

Categories: Eye diseases, Neuronal diseases
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Aliases & Classifications for Spontaneous Ocular Nystagmus

MalaCards integrated aliases for Spontaneous Ocular Nystagmus:

Name: Spontaneous Ocular Nystagmus 11 14 71
Visual Deprivation Nystagmus 11 33
Searching Eye Movements 11
Nystagmus, Pathologic 43
Ocular Nystagmus 11

Classifications:



External Ids:

Disease Ontology 11 DOID:11771
ICD9CM 34 379.53
MeSH 43 D009759
SNOMED-CT 68 39771000
ICD11 33 1897263039
UMLS 71 C0271384

Summaries for Spontaneous Ocular Nystagmus

MalaCards based summary: Spontaneous Ocular Nystagmus, also known as visual deprivation nystagmus, is related to pathologic nystagmus and papillon-lefevre syndrome, and has symptoms including deficiencies of smooth pursuit movements An important gene associated with Spontaneous Ocular Nystagmus is FRMD7 (FERM Domain Containing 7). The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, caudate nucleus and cortex.

Related Diseases for Spontaneous Ocular Nystagmus

Diseases related to Spontaneous Ocular Nystagmus via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pathologic nystagmus 10.1
2 papillon-lefevre syndrome 9.8
3 vestibular nystagmus 9.8
4 lateral medullary syndrome 9.8
5 temporal lobe neoplasm 9.8 GRIN2A CALB1
6 speech disorder 9.7 GRIN2A CALB1

Graphical network of the top 20 diseases related to Spontaneous Ocular Nystagmus:



Diseases related to Spontaneous Ocular Nystagmus

Symptoms & Phenotypes for Spontaneous Ocular Nystagmus

UMLS symptoms related to Spontaneous Ocular Nystagmus:


deficiencies of smooth pursuit movements

Drugs & Therapeutics for Spontaneous Ocular Nystagmus

Drugs for Spontaneous Ocular Nystagmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Memantine Approved, Investigational Phase 4 41100-52-1, 19982-08-2 4054
2
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
3
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5 Neurotransmitter Agents Phase 4
6 Dopamine Agents Phase 4
7 Anti-Anxiety Agents Phase 4
8 Antiparkinson Agents Phase 4
9 Excitatory Amino Acid Antagonists Phase 4
10 Psychotropic Drugs Phase 4
11 Anticonvulsants Phase 4
12 Analgesics Phase 4
13 Carbonic Anhydrase Inhibitors Phase 4
14 Ophthalmic Solutions Phase 4
15 Pharmaceutical Solutions Phase 4
16 Kava Approved, Investigational, Nutraceutical 9000-38-8

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Oculopalatal Tremor: a Controled Open-label Study Completed NCT02466191 Phase 4 Memantine;Gabapentin
2 Topical Brinzolamide Ophthalmic Suspension Versus Placebo in the Treatment of Infantile Nystagmus Syndrome Completed NCT01312402 Phase 4 topical brinzolamide 1% in 5mL ophthalmic medication;Placebo in 5 mL dispenser
3 Efficacy and Safety of Neramexane Mesylate in Congenital Idiopathic Nystagmus and Acquired Nystagmus: a Randomized, Double-blind, Placebo-controlled, Single Center, Proof of Concept Study Using a Two-period Cross-over Design Completed NCT00661440 Phase 2 Neramexane mesylate
4 Horizontal Rectus Tenotomy in the Treatment of Congenital Nystagmus Completed NCT00001866 Phase 2
5 Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Multiple Sclerosis Completed NCT01744444 Phase 2 Memantine;Gabapentin
6 Long-term Open-label Extension Study to Assess the Safety, Tolerability, and Efficacy of Neramexane Mesylate in Congenital Idiopathic Nystagmus and Acquired Nystagmus Terminated NCT00799942 Phase 2 Neramexane mesylate
7 Phase 2 Study of 4-Aminopyridine for the Treatment of Episodic Ataxia Type 2 Withdrawn NCT01543750 Phase 2 4-Aminopyridine;Placebo
8 Effects of Vestibular Rehabilitation in the Treatment of Patients With Acute Vestibular Loss. - A Randomized Controlled Trial Completed NCT00702832
9 Clinical Application of Objective Visual Acuity Measurement Using Suppression Method to Inhibit Optokinetic Nystagmus (OKN). Completed NCT04642495
10 Screening Study for the Evaluation and Diagnosis of Potential Research Subjects With Nystagmus or Strabismus Completed NCT00001861
11 Investigation and Treatment of Ocular Motor Disorders: Cross-over Comparison of Gabapentin and Memantine as Treatment for Nystagmus Completed NCT00928954 gabapentin;memantine
12 Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Healthy Volunteer Trial Completed NCT03661762
13 Prevalence of Positional Nystagmus in a Population of Healthy Adults Recruiting NCT05554770
14 Biofeedback in Idiopathic Infantile Nystagmus Syndrome Recruiting NCT04142307
15 Randomized Controlled Trial on Nystagmus Assessment for Patients Consulting for Acute Vertigo in the Emergency Department With/Without Frenzel Lens With/Without Form: A Pilot Study Recruiting NCT05176015
16 Coordination of Rare Diseases at Sanford Recruiting NCT01793168
17 Normative Data for Post-rotatory Nystagmus Test at Spanish Adolescent and Adult Population: a Transversal Study Not yet recruiting NCT04788134

Search NIH Clinical Center for Spontaneous Ocular Nystagmus

Cochrane evidence based reviews: nystagmus, pathologic

Genetic Tests for Spontaneous Ocular Nystagmus

Anatomical Context for Spontaneous Ocular Nystagmus

Organs/tissues related to Spontaneous Ocular Nystagmus:

MalaCards : Eye, Caudate Nucleus, Cortex, Cerebellum, Brain

Publications for Spontaneous Ocular Nystagmus

Articles related to Spontaneous Ocular Nystagmus:

(show top 50) (show all 107)
# Title Authors PMID Year
1
Reduced Gain and Shortened Time Constant of Vestibular Velocity Storage as a Source of Balance and Movement Sensitivities in Gravitational Insecurity. 62
35600904 2022
2
MIF versus SIF Motoneurons, What Are Their Respective Contribution in the Oculomotor Medial Rectus Pool? 62
34675089 2021
3
Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model of acute peripheral vestibulopathy. 62
34419105 2021
4
Sparse classification of discriminant nystagmus features using combined video-oculography tests and pupil tracking for common vestibular disorder recognition. 62
33043702 2021
5
Altered visual population receptive fields in human albinism. 62
32334151 2020
6
Vestibular, locomotor, and vestibulo-autonomic research: 50 years of collaboration with Bernard Cohen. 62
31747361 2020
7
The Eight Years' War: Court Sides With TMA in Long-Running Chiropractic Case on Vestibular Testing. 62
30817842 2019
8
Absence of Rotation Perception during Warm Water Caloric Irrigation in Some Seniors with Postural Instability. 62
26834699 2016
9
Temporal changes of calbindin expression in the nodulus following unilateral labyrinthectomy in rats. 62
24055607 2013
10
Wernicke's encephalopathy and central pontine myelinolysis in hyperemesis gravidarum. 62
23546346 2013
11
On the vertigo due to static magnetic fields. 62
24205304 2013
12
Infantile and acquired nystagmus in childhood. 62
22459007 2012
13
Head and eye movements in rats with pontine reticular lesions in comparison with primates: a scientific memoir and a fresh look at some old and 'new' data. 62
22044476 2012
14
Nystagmus and oscillopsia. 62
21906211 2012
15
Absence of spatial updating when the visuomotor system is unsure about stimulus motion. 62
21775600 2011
16
Modeling the nonlinear context dependency of the neural integrator in the vestibuloocular reflex. 62
18632357 2008
17
Impulsive head rotation resets oculopalatal tremor: examination of a model. 62
18718306 2008
18
Biomechanics of horizontal canal benign paroxysmal positional vertigo. 62
16286702 2005
19
Foveation period and waveforms of congenital ocular nystagmus. 62
16193687 2005
20
[Influence of periodic light effects on the parameters of the ocular nystagmus]. 62
15529545 2004
21
Improved algorithm for classification of ocular nystagmus. 62
17271731 2004
22
Influence of gravity on the spatial orientation of eye nystagmus induced by unilateral lesion of horizontal semicircular canal. 62
11603766 2000
23
Principles underlying real-time nystagmus analysis of horizontal and vertical eye movements recorded with electro-, infra-red-, or video-oculographic techniques. 62
9842515 1998
24
The role of tonic vestibular input for postural control in rats. 62
9177127 1997
25
Dissociations between behavioural recovery and restoration of vestibular activity in the unilabyrinthectomized guinea-pig. 62
9147334 1997
26
Nitric oxide production by brain stem neurons is required for normal performance of eye movements in alert animals. 62
8893030 1996
27
Evidence that short ACTH fragments enhance vestibular compensation via direct action on the ipsilateral vestibular nucleus. 62
8856704 1996
28
Early diazepam treatment following unilateral labyrinthectomy does not impair vestibular compensation of spontaneous nystagmus in guinea pig. 62
8925116 1996
29
Effect of location and orientation uncertainty on r.m.s. contrast sensitivity with and without spatial noise in peripheral and foveal vision. 62
7566901 1995
30
Comparison of surgeries for removal of primary vestibular inputs: a combined anatomical and behavioral study in rats. 62
7715388 1995
31
Methylprednisolone reduces spontaneous nystagmus following unilateral labyrinthectomy in guinea pig. 62
7768297 1995
32
Ginkgolide B accelerates vestibular compensation of spontaneous ocular nystagmus in guinea pig following unilateral labyrinthectomy. 62
7895826 1995
33
Update on strabismus and amblyopia. 62
8574880 1995
34
Evidence suggesting individual ocular motor control of each eye (muscle). 62
7994479 1994
35
[The interaction of vestibular inputs with differing orientations of the otoliths in a gravitational field]. 62
7534567 1994
36
Limited visual search on the WAIS Picture Completion test in patients with schizophrenia. 62
8018587 1994
37
A dose-response analysis of the beneficial effects of the ACTH-(4-9) analogue, Org 2766, on behavioural recovery following unilateral labyrinthectomy in guinea-pig. 62
8012719 1994
38
Unilateral ablation of the frontal eye field of the rat affects the beating field of ocular nystagmus. 62
8056062 1994
39
Evidence that L-type calcium channels do not contribute to static vestibular function in the guinea pig vestibular nucleus. 62
7509710 1993
40
Evidence for separate eye and head position command signals in unrestrained rats. 62
8121615 1993
41
Middle ear procaine injection before surgical labyrinthectomy reduces nystagmus. 62
8260619 1993
42
Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs. 62
8491266 1993
43
Angular velocity detection by head movements orthogonal to the plane of rotation. 62
8405254 1993
44
Role of irregular otolith afferents in the steady-state nystagmus during off-vertical axis rotation. 62
1479452 1992
45
Role of NMDA receptors in the compensation of ocular nystagmus induced by hemilabyrinthectomy in the guinea pig. 62
1362639 1992
46
Pretreatment with MK-801 reduces spontaneous nystagmus following unilateral labyrinthectomy. 62
1330616 1992
47
Behavioural and neural correlates of vestibular compensation. 62
1344074 1992
48
Pre-treatment with a Ca2+ channel antagonist facilitates vestibular compensation. 62
1623162 1992
49
Characteristics of nystagmus evoked by electrical stimulation of the uvular/nodular lobules of the cerebellum in monkey. 62
1342399 1992
50
Parametric classification of segments in ocular nystagmus. 62
2066123 1991

Variations for Spontaneous Ocular Nystagmus

Expression for Spontaneous Ocular Nystagmus

Search GEO for disease gene expression data for Spontaneous Ocular Nystagmus.

Pathways for Spontaneous Ocular Nystagmus

GO Terms for Spontaneous Ocular Nystagmus

Biological processes related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual learning GO:0008542 9.46 HRH1 GRIN2A
2 vesicle fusion with Golgi apparatus GO:0048280 9.26 YIPF7 YIPF5
3 regulation of synaptic plasticity GO:0048167 9.02 HRH1 GRIN2A CALB1

Sources for Spontaneous Ocular Nystagmus

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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