Spontaneous Ocular Nystagmus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Spontaneous Ocular Nystagmus, also known as visual deprivation nystagmus, is related to pathologic nystagmus and papillon-lefevre syndrome, and has symptoms including deficiencies of smooth pursuit movements An important gene associated with Spontaneous Ocular Nystagmus is FRMD7 (FERM Domain Containing 7). The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, caudate nucleus and cortex.

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Related Diseases for Spontaneous Ocular Nystagmus

Diseases related to Spontaneous Ocular Nystagmus via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	pathologic nystagmus	10.1
2	papillon-lefevre syndrome	9.8
3	vestibular nystagmus	9.8
4	lateral medullary syndrome	9.8
5	temporal lobe neoplasm	9.8	GRIN2A CALB1
6	speech disorder	9.7	GRIN2A CALB1

Graphical network of the top 20 diseases related to Spontaneous Ocular Nystagmus:

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Symptoms & Phenotypes for Spontaneous Ocular Nystagmus

UMLS symptoms related to Spontaneous Ocular Nystagmus:

deficiencies of smooth pursuit movements

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Drugs & Therapeutics for Spontaneous Ocular Nystagmus

Drugs for Spontaneous Ocular Nystagmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Memantine

Approved, Investigational

Phase 4

41100-52-1, 19982-08-2

4054

2

Dopamine

Approved

Phase 4

62-31-7, 51-61-6

681

3

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

4

Brinzolamide

Approved

Phase 4

138890-62-7

68844

5

Neurotransmitter Agents

Phase 4

6

Dopamine Agents

Phase 4

7

Anti-Anxiety Agents

Phase 4

8

Antiparkinson Agents

Phase 4

9

Excitatory Amino Acid Antagonists

Phase 4

10

Psychotropic Drugs

Phase 4

11

Anticonvulsants

Phase 4

12

Analgesics

Phase 4

13

Carbonic Anhydrase Inhibitors

Phase 4

14

Ophthalmic Solutions

Phase 4

15

Pharmaceutical Solutions

Phase 4

16

Kava

Approved, Investigational, Nutraceutical

9000-38-8

Interventional clinical trials:

(show all 17)

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Oculopalatal Tremor: a Controled Open-label Study	Completed	NCT02466191	Phase 4	Memantine;Gabapentin
2	Topical Brinzolamide Ophthalmic Suspension Versus Placebo in the Treatment of Infantile Nystagmus Syndrome	Completed	NCT01312402	Phase 4	topical brinzolamide 1% in 5mL ophthalmic medication;Placebo in 5 mL dispenser
3	Efficacy and Safety of Neramexane Mesylate in Congenital Idiopathic Nystagmus and Acquired Nystagmus: a Randomized, Double-blind, Placebo-controlled, Single Center, Proof of Concept Study Using a Two-period Cross-over Design	Completed	NCT00661440	Phase 2	Neramexane mesylate
4	Horizontal Rectus Tenotomy in the Treatment of Congenital Nystagmus	Completed	NCT00001866	Phase 2
5	Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Multiple Sclerosis	Completed	NCT01744444	Phase 2	Memantine;Gabapentin
6	Long-term Open-label Extension Study to Assess the Safety, Tolerability, and Efficacy of Neramexane Mesylate in Congenital Idiopathic Nystagmus and Acquired Nystagmus	Terminated	NCT00799942	Phase 2	Neramexane mesylate
7	Phase 2 Study of 4-Aminopyridine for the Treatment of Episodic Ataxia Type 2	Withdrawn	NCT01543750	Phase 2	4-Aminopyridine;Placebo
8	Effects of Vestibular Rehabilitation in the Treatment of Patients With Acute Vestibular Loss. - A Randomized Controlled Trial	Completed	NCT00702832
9	Clinical Application of Objective Visual Acuity Measurement Using Suppression Method to Inhibit Optokinetic Nystagmus (OKN).	Completed	NCT04642495
10	Screening Study for the Evaluation and Diagnosis of Potential Research Subjects With Nystagmus or Strabismus	Completed	NCT00001861
11	Investigation and Treatment of Ocular Motor Disorders: Cross-over Comparison of Gabapentin and Memantine as Treatment for Nystagmus	Completed	NCT00928954		gabapentin;memantine
12	Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Healthy Volunteer Trial	Completed	NCT03661762
13	Prevalence of Positional Nystagmus in a Population of Healthy Adults	Recruiting	NCT05554770
14	Biofeedback in Idiopathic Infantile Nystagmus Syndrome	Recruiting	NCT04142307
15	Randomized Controlled Trial on Nystagmus Assessment for Patients Consulting for Acute Vertigo in the Emergency Department With/Without Frenzel Lens With/Without Form: A Pilot Study	Recruiting	NCT05176015
16	Coordination of Rare Diseases at Sanford	Recruiting	NCT01793168
17	Normative Data for Post-rotatory Nystagmus Test at Spanish Adolescent and Adult Population: a Transversal Study	Not yet recruiting	NCT04788134

Search NIH Clinical Center for Spontaneous Ocular Nystagmus

Cochrane evidence based reviews: nystagmus, pathologic

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Genetic Tests for Spontaneous Ocular Nystagmus

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Anatomical Context for Spontaneous Ocular Nystagmus

Organs/tissues related to Spontaneous Ocular Nystagmus:

MalaCards : Eye, Caudate Nucleus, Cortex, Cerebellum, Brain

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Publications for Spontaneous Ocular Nystagmus

Articles related to Spontaneous Ocular Nystagmus:

(show top 50) (show all 107)

#	Title	Authors	PMID	Year
1	Reduced Gain and Shortened Time Constant of Vestibular Velocity Storage as a Source of Balance and Movement Sensitivities in Gravitational Insecurity. ⁶²	Potegal M...McKnight S	35600904	2022
2	MIF versus SIF Motoneurons, What Are Their Respective Contribution in the Oculomotor Medial Rectus Pool? ⁶²	Carrero-Rojas G...Pastor AM	34675089	2021
3	Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model of acute peripheral vestibulopathy. ⁶²	El Mahmoudi N...Tighilet B	34419105	2021
4	Sparse classification of discriminant nystagmus features using combined video-oculography tests and pupil tracking for common vestibular disorder recognition. ⁶²	Mouelhi A...Labidi S	33043702	2021
5	Altered visual population receptive fields in human albinism. ⁶²	Alvarez I...Clark CA	32334151	2020
6	Vestibular, locomotor, and vestibulo-autonomic research: 50 years of collaboration with Bernard Cohen. ⁶²	Raphan T	31747361	2020
7	The Eight Years' War: Court Sides With TMA in Long-Running Chiropractic Case on Vestibular Testing. ⁶²	Berlin J	30817842	2019
8	Absence of Rotation Perception during Warm Water Caloric Irrigation in Some Seniors with Postural Instability. ⁶²	Chiarovano E...de Waele C	26834699	2016
9	Temporal changes of calbindin expression in the nodulus following unilateral labyrinthectomy in rats. ⁶²	Park BR...Hong SM	24055607	2013
10	Wernicke's encephalopathy and central pontine myelinolysis in hyperemesis gravidarum. ⁶²	Sutamnartpong P...Kulkantrakorn K	23546346	2013
11	On the vertigo due to static magnetic fields. ⁶²	Mian OS...Day BL	24205304	2013
12	Infantile and acquired nystagmus in childhood. ⁶²	Ehrt O	22459007	2012
13	Head and eye movements in rats with pontine reticular lesions in comparison with primates: a scientific memoir and a fresh look at some old and 'new' data. ⁶²	Sirkin DW	22044476	2012
14	Nystagmus and oscillopsia. ⁶²	Straube A...European Federation of Neurologic Societies	21906211	2012
15	Absence of spatial updating when the visuomotor system is unsure about stimulus motion. ⁶²	Van Barneveld DC...Van Opstal AJ	21775600	2011
16	Modeling the nonlinear context dependency of the neural integrator in the vestibuloocular reflex. ⁶²	Chan WW...Galiana HL	18632357	2008
17	Impulsive head rotation resets oculopalatal tremor: examination of a model. ⁶²	Liao K...Leigh RJ	18718306	2008
18	Biomechanics of horizontal canal benign paroxysmal positional vertigo. ⁶²	Rajguru SM...Rabbitt RD	16286702	2005
19	Foveation period and waveforms of congenital ocular nystagmus. ⁶²	Dorn L...Dorn V	16193687	2005
20	[Influence of periodic light effects on the parameters of the ocular nystagmus]. ⁶²	Usanov DA...Gubkina GL	15529545	2004
21	Improved algorithm for classification of ocular nystagmus. ⁶²	Radinsky I...Galiana HL	17271731	2004
22	Influence of gravity on the spatial orientation of eye nystagmus induced by unilateral lesion of horizontal semicircular canal. ⁶²	Pettorossi VE...Silvarosa G	11603766	2000
23	Principles underlying real-time nystagmus analysis of horizontal and vertical eye movements recorded with electro-, infra-red-, or video-oculographic techniques. ⁶²	Allum JH...Troescher M	9842515	1998
24	The role of tonic vestibular input for postural control in rats. ⁶²	Deliagina TG...Grant G	9177127	1997
25	Dissociations between behavioural recovery and restoration of vestibular activity in the unilabyrinthectomized guinea-pig. ⁶²	Ris L...Godaux E	9147334	1997
26	Nitric oxide production by brain stem neurons is required for normal performance of eye movements in alert animals. ⁶²	Moreno-Lopez B...Estrada C	8893030	1996
27	Evidence that short ACTH fragments enhance vestibular compensation via direct action on the ipsilateral vestibular nucleus. ⁶²	Gilchrist DP...Smith PF	8856704	1996
28	Early diazepam treatment following unilateral labyrinthectomy does not impair vestibular compensation of spontaneous nystagmus in guinea pig. ⁶²	Martin J...Darlington CL	8925116	1996
29	Effect of location and orientation uncertainty on r.m.s. contrast sensitivity with and without spatial noise in peripheral and foveal vision. ⁶²	Ukkonen O...Nasanen R	7566901	1995
30	Comparison of surgeries for removal of primary vestibular inputs: a combined anatomical and behavioral study in rats. ⁶²	Li H...Rubin AM	7715388	1995
31	Methylprednisolone reduces spontaneous nystagmus following unilateral labyrinthectomy in guinea pig. ⁶²	Jerram AH...Smith PF	7768297	1995
32	Ginkgolide B accelerates vestibular compensation of spontaneous ocular nystagmus in guinea pig following unilateral labyrinthectomy. ⁶²	Maclennan K...Darlington CL	7895826	1995
33	Update on strabismus and amblyopia. ⁶²	Campos EC	8574880	1995
34	Evidence suggesting individual ocular motor control of each eye (muscle). ⁶²	Dell'Osso LF	7994479	1994
35	[The interaction of vestibular inputs with differing orientations of the otoliths in a gravitational field]. ⁶²	Stolbkov IuK...Sabanov VS	7534567	1994
36	Limited visual search on the WAIS Picture Completion test in patients with schizophrenia. ⁶²	Kurachi M...Yamaguchi N	8018587	1994
37	A dose-response analysis of the beneficial effects of the ACTH-(4-9) analogue, Org 2766, on behavioural recovery following unilateral labyrinthectomy in guinea-pig. ⁶²	Gilchrist DP...Smith PF	8012719	1994
38	Unilateral ablation of the frontal eye field of the rat affects the beating field of ocular nystagmus. ⁶²	Bahring R...Dieringer N	8056062	1994
39	Evidence that L-type calcium channels do not contribute to static vestibular function in the guinea pig vestibular nucleus. ⁶²	Sansom AJ...Darlington CL	7509710	1993
40	Evidence for separate eye and head position command signals in unrestrained rats. ⁶²	Dieringer N...Meier RK	8121615	1993
41	Middle ear procaine injection before surgical labyrinthectomy reduces nystagmus. ⁶²	Darlington CL...Smith PF	8260619	1993
42	Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs. ⁶²	Sansom AJ...Kenyon R	8491266	1993
43	Angular velocity detection by head movements orthogonal to the plane of rotation. ⁶²	Hess BJ...Angelaki DE	8405254	1993
44	Role of irregular otolith afferents in the steady-state nystagmus during off-vertical axis rotation. ⁶²	Angelaki DE...Strunk CL	1479452	1992
45	Role of NMDA receptors in the compensation of ocular nystagmus induced by hemilabyrinthectomy in the guinea pig. ⁶²	Pettorossi VE...Errico P	1362639	1992
46	Pretreatment with MK-801 reduces spontaneous nystagmus following unilateral labyrinthectomy. ⁶²	Sansom AJ...Smith PF	1330616	1992
47	Behavioural and neural correlates of vestibular compensation. ⁶²	Curthoys IS...Halmagyi GM	1344074	1992
48	Pre-treatment with a Ca2+ channel antagonist facilitates vestibular compensation. ⁶²	Darlington CL...Smith PF	1623162	1992
49	Characteristics of nystagmus evoked by electrical stimulation of the uvular/nodular lobules of the cerebellum in monkey. ⁶²	Heinen SJ...Keller EL	1342399	1992
50	Parametric classification of segments in ocular nystagmus. ⁶²	Rey CG...Galiana HL	2066123	1991

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Genes for Spontaneous Ocular Nystagmus

Genes related to Spontaneous Ocular Nystagmus (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FRMD7	FERM Domain Containing 7	Protein Coding	5.64	DISEASES inferred ¹⁴
2	YIPF5	Yip1 Domain Family Member 5	Protein Coding	4.93	DISEASES inferred ¹⁴
3	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	4.91	DISEASES inferred ¹⁴
4	LYST	Lysosomal Trafficking Regulator	Protein Coding	4.88	DISEASES inferred ¹⁴
5	ARL13A	ADP Ribosylation Factor Like GTPase 13A	Protein Coding	4.77	DISEASES inferred ¹⁴
6	YIPF7	Yip1 Domain Family Member 7	Protein Coding	4.62	DISEASES inferred ¹⁴
7	CALB1	Calbindin 1	Protein Coding	4.58	DISEASES inferred ¹⁴
8	RBPJL	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region Like	Protein Coding	4.47	DISEASES inferred ¹⁴
9	HRH1	Histamine Receptor H1	Protein Coding	4.46	DISEASES inferred ¹⁴
10	FUT2	Fucosyltransferase 2	Protein Coding	4.46	DISEASES inferred ¹⁴

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Variations for Spontaneous Ocular Nystagmus

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Expression for Spontaneous Ocular Nystagmus

Search GEO for disease gene expression data for Spontaneous Ocular Nystagmus.

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Pathways for Spontaneous Ocular Nystagmus

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GO Terms for Spontaneous Ocular Nystagmus

Biological processes related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	visual learning	GO:0008542	9.46	HRH1 GRIN2A
2	vesicle fusion with Golgi apparatus	GO:0048280	9.26	YIPF7 YIPF5
3	regulation of synaptic plasticity	GO:0048167	9.02	HRH1 GRIN2A CALB1

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Sources for Spontaneous Ocular Nystagmus

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SPN033 MIFTS: 27	Spontaneous Ocular Nystagmus Categories: Eye diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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