Spontaneous Ocular Nystagmus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN033 MIFTS: 33	Spontaneous Ocular Nystagmus Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Spontaneous Ocular Nystagmus

MalaCards integrated aliases for Spontaneous Ocular Nystagmus:

Name: Spontaneous Ocular Nystagmus ¹² ¹⁵ ⁷³

Visual Deprivation Nystagmus ¹²

Searching Eye Movements ¹²

Nystagmus, Pathologic ⁴⁴

Ocular Nystagmus ¹²

Classifications:

MalaCards categories:
Anatomical: Eye diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:11771

ICD10 ³³ H55.03

ICD9CM ³⁵ 379.53

MeSH ⁴⁴ D009759

SNOMED-CT ⁶⁸ 39771000 45339001

UMLS ⁷³ C0271384

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Summaries for Spontaneous Ocular Nystagmus

MalaCards based summary : Spontaneous Ocular Nystagmus, also known as visual deprivation nystagmus, is related to pathologic nystagmus and long qt syndrome, and has symptoms including deficiencies of smooth pursuit movements An important gene associated with Spontaneous Ocular Nystagmus is FRMD7 (FERM Domain Containing 7), and among its related pathways/superpathways are Metabolism and DAG and IP3 signaling. Affiliated tissues include eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Spontaneous Ocular Nystagmus

Diseases related to Spontaneous Ocular Nystagmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)

#	Related Disease	Score	Top Affiliating Genes
1	pathologic nystagmus	10.0
2	long qt syndrome	9.9	CALM1 CALM2 CALM3
3	long qt syndrome 1	9.9	CALM1 CALM2 CALM3
4	long qt syndrome 15	9.9	CALM1 CALM2 CALM3
5	vestibular nystagmus	9.9	FUT2 MED12
6	otomycosis	9.9	CALM1 CALM2 CALM3
7	external ear disease	9.9	CALM1 CALM2 CALM3
8	emery-dreifuss muscular dystrophy 5, autosomal dominant	9.9	CALM1 CALM2 CALM3
9	sporotrichosis	9.9	CALM1 CALM2 CALM3
10	otitis externa	9.9	CALM1 CALM2 CALM3
11	deafness, autosomal recessive 44	9.9	CALM1 CALM2 CALM3
12	acute dacryocystitis	9.9	CALM1 CALM2 CALM3
13	dystonia 24	9.9	CALM1 CALM2 CALM3
14	gestational choriocarcinoma	9.9	CALM1 CALM2 CALM3
15	triosephosphate isomerase deficiency	9.9	CALM1 CALM2 CALM3
16	leber congenital amaurosis 2	9.9	CALM1 CALM2 CALM3
17	tinea unguium	9.9	CALM1 CALM2 CALM3
18	primary systemic mycosis	9.9	CALM1 CALM2 CALM3
19	clear cell acanthoma	9.9	CALM1 CALM2 CALM3
20	cardiomyopathy, dilated, 1a	9.9	CALM1 CALM2 CALM3
21	cardiomyopathy, dilated, 1p	9.9	CALM1 CALM2 CALM3
22	phaeohyphomycosis	9.8	CALM1 CALM2 CALM3
23	deafness, autosomal dominant 2a	9.8	CALM1 CALM2 CALM3
24	microcephaly 2, primary, autosomal recessive, with or without cortical malformations	9.8	CALM1 CALM2 CALM3
25	ceroid lipofuscinosis, neuronal, 11	9.8	CALM1 CALM2 CALM3
26	papillon-lefevre syndrome	9.8
27	lateral medullary syndrome	9.8
28	primary cutaneous amyloidosis	9.8	CALM1 CALM2 CALM3
29	catecholaminergic polymorphic ventricular tachycardia	9.8	CALM1 CALM2 CALM3
30	cardiac arrest	9.7	CALM1 CALM2 CALM3

Graphical network of the top 20 diseases related to Spontaneous Ocular Nystagmus:

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Symptoms & Phenotypes for Spontaneous Ocular Nystagmus

UMLS symptoms related to Spontaneous Ocular Nystagmus:

deficiencies of smooth pursuit movements

GenomeRNAi Phenotypes related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-101	9.5	CALB1 CALM2 POMC
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	9.5	POMC
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	9.5	POMC
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	9.5	CALM2
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	9.5	CALB1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.5	CALB1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	9.5	POMC
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.5	POMC
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.5	CALB1 CALM2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-88	9.5	POMC
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	9.5	POMC
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	9.5	CALB1

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Drugs & Therapeutics for Spontaneous Ocular Nystagmus

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Safety and Feasibility of Using Epicall for Monitoring Pre-seizure Biomarkers	Unknown status	NCT01436695

Search NIH Clinical Center for Spontaneous Ocular Nystagmus

Cochrane evidence based reviews: nystagmus, pathologic

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Genetic Tests for Spontaneous Ocular Nystagmus

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Anatomical Context for Spontaneous Ocular Nystagmus

MalaCards organs/tissues related to Spontaneous Ocular Nystagmus:

⁴¹

Eye

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Publications for Spontaneous Ocular Nystagmus

Articles related to Spontaneous Ocular Nystagmus:

#	Title	Authors	Year
1	Ginkgolide B accelerates vestibular compensation of spontaneous ocular nystagmus in guinea pig following unilateral labyrinthectomy. ( 7895826 )	MacLennan K....Darlington C.L.	1995
2	Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs. ( 8491266 )		1993

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Genes for Spontaneous Ocular Nystagmus

Genes related to Spontaneous Ocular Nystagmus (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FRMD7	FERM Domain Containing 7	Protein Coding	16.16	DISEASES inferred ¹⁵
2	MED12	Mediator Complex Subunit 12	Protein Coding	15.45	DISEASES inferred ¹⁵
3	FUT2	Fucosyltransferase 2	Protein Coding	15.13	DISEASES inferred ¹⁵
4	CALM3	Calmodulin 3	Protein Coding	14.24	DISEASES inferred ¹⁵
5	CALM1	Calmodulin 1	Protein Coding	14.23	DISEASES inferred ¹⁵
6	CALM2	Calmodulin 2	Protein Coding	14.23	DISEASES inferred ¹⁵
7	POMC	Proopiomelanocortin	Protein Coding	14	DISEASES inferred ¹⁵
8	CSPG5	Chondroitin Sulfate Proteoglycan 5	Protein Coding	5.97	DISEASES inferred ¹⁵
9	CALB1	Calbindin 1	Protein Coding	4.81	DISEASES inferred ¹⁵

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Variations for Spontaneous Ocular Nystagmus

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Expression for Spontaneous Ocular Nystagmus

Search GEO for disease gene expression data for Spontaneous Ocular Nystagmus.

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Pathways for Spontaneous Ocular Nystagmus

Pathways related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

(show top 50) (show all 85)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolic pathways ³⁷ Metabolism of lipids and lipoproteins ⁶⁶	13.93	CALM1 CALM2 CALM3 CSPG5 FUT2 MED12
2	DAG and IP3 signaling ⁶⁶ Show member pathways Beta-2 adrenergic-dependent CFTR expression ²² Ca-dependent events ⁶⁶ Calmodulin induced events ⁶⁶ CaM pathway ⁶⁶ Cam-PDE 1 activation ⁶⁶ CREB phosphorylation through the activation of Adenylate Cyclase ⁶⁶ Development Beta-adrenergic receptors signaling via cAMP ²² Development Role of Activin A in cell differentiation and proliferation ²² EGFR interacts with phospholipase C-gamma ⁶⁶ G Protein Signaling Pathways ¹ G-protein mediated events ⁶⁶ Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling ²² Neurophysiological process PGE2-induced pain processing ²² Opioid Signalling ⁶⁶ PKA activation ⁶⁶ PKA activation in glucagon signalling ⁶⁶ PKA-mediated phosphorylation of CREB ⁶⁶ PLC beta mediated events ⁶⁶ PLC-gamma1 signalling ⁶⁶ Signal transduction Calcium signaling ²²	12.97	CALM1 CALM2 CALM3 POMC
3	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴ Hedgehog Signaling in Mammals ⁶⁴ Relaxin Pathway ⁶⁴ Signaling in Gap Junctions ⁶⁴	12.91	CALM1 CALM2 CALM3 POMC
4	Glycosaminoglycan metabolism ⁶⁶ Show member pathways chondroitin sulfate biosynthesis ¹ chondroitin sulfate biosynthesis (late stages) ¹ Heparan sulfate/heparin (HS-GAG) metabolism ⁶⁶ HS-GAG biosynthesis ⁶⁶ Hyaluronan biosynthesis and export ⁶⁶ Hyaluronan metabolism ⁶⁶ Hyaluronan uptake and degradation ⁶⁶ Metabolism of carbohydrates ⁶⁶	12.76	CALM1 CALM2 CALM3 CSPG5
5	Aldosterone synthesis and secretion ³⁷ Show member pathways Adrenergic signaling in cardiomyocytes ³⁷ Ca2+ activated K+ channels ⁶⁶ Cortisol synthesis and secretion ³⁷ Insulin secretion ³⁷ Thyroid hormone synthesis ³⁷	12.66	CALM1 CALM2 CALM3 POMC
6	Development Dopamine D2 receptor transactivation of EGFR ²² Show member pathways Apoptosis and survival BAD phosphorylation ²² BAD Phosphorylation ⁶⁴ Chemotaxis CXCR4 signaling pathway ²² Development Alpha-2 adrenergic receptor activation of ERK ²²	12.46	CALM1 CALM2 CALM3
7	Ion channel transport ⁶⁶ Show member pathways Stimuli-sensing channels ⁶⁶	12.43	CALM1 CALM2 CALM3
8	Myometrial Relaxation and Contraction Pathways ¹ Show member pathways Calcium Regulation in the Cardiac Cell ¹	12.43	CALM1 CALM2 CALM3
9	ADP signalling through P2Y purinoceptor 12 ⁶⁶ Show member pathways Adrenaline,noradrenaline inhibits insulin secretion ⁶⁶ Beta-agonist/Beta-blocker Pathway, Pharmacodynamics ⁶¹ Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding ⁶⁶ G alpha (z) signalling events ⁶⁶ G-protein activation ⁶⁶ Signal transduction cAMP signaling ²²	12.42	CALM1 CALM2 CALM3 POMC
10	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁷	12.41	CALM1 CALM2 CALM3
11	DREAM Repression and Dynorphin Expression ⁶⁴ Show member pathways BMP Pathway ⁶⁴ Caspase Cascade ⁶⁴ Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels ⁶⁶ nNOS Signaling in Skeletal Muscle ⁶⁴ TOB in Osteoblast Signaling ⁶⁴	12.39	CALM1 CALM2 CALM3
12	Aquaporin-mediated transport ⁶⁶ Show member pathways Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation ²² Glucagon signaling in metabolic regulation ⁶⁶ Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ⁶⁶ Passive transport by Aquaporins ⁶⁶ Transport of glycerol from adipocytes to the liver by Aquaporins ⁶⁶ Vasopressin regulates renal water homeostasis via Aquaporins ⁶⁶	12.34	CALM1 CALM2 CALM3
13	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	12.34	CALM1 CALM2 CALM3
14	Presynaptic function of Kainate receptors ⁶⁶ Show member pathways Activation of Ca-permeable Kainate Receptor ⁶⁶ Activation of Kainate Receptors upon glutamate binding ⁶⁶ Activation of Na-permeable Kainate Receptors ⁶⁶ Calcitonin-like ligand receptors ⁶⁶ Class B/2 (Secretin family receptors) ⁶⁶ G beta-gamma signalling through PLC beta ⁶⁶ Glucagon-type ligand receptors ⁶⁶ G-Protein Signaling through Tubby Protein ⁶⁴ Ionotropic activity of Kainate Receptors ⁶⁶	12.32	CALM1 CALM2 CALM3
15	Semaphorin interactions ⁶⁶ Show member pathways CRMPs in Sema3A signaling ⁶⁶ Inhibition of Ribosome Biogenesis by p19(ARF) ⁶⁴ Other semaphorin interactions ⁶⁶ RHO GTPases activate CIT ⁶⁶ RHO GTPases activate PAKs ⁶⁶ RHO GTPases Activate ROCKs ⁶⁶ Sema3A PAK dependent Axon repulsion ⁶⁶ SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion ⁶⁶ Sema4D in semaphorin signaling ⁶⁶ Sema4D induced cell migration and growth-cone collapse ⁶⁶ Sema4D mediated inhibition of cell attachment and migration ⁶⁶	12.32	CALM1 CALM2 CALM3
16	RhoGDI Pathway ⁶⁴ Show member pathways Fc-GammaR-Mediated Phagocytosis in Macrophages ⁶⁴	12.31	CALM1 CALM2 CALM3
17	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	12.3	CALM1 CALM2 CALM3
18	B cell receptor signaling pathway (KEGG) ³⁷ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.29	CALM1 CALM2 CALM3
19	Dopamine-DARPP32 Feedback onto cAMP Pathway ⁶⁴	12.27	CALM1 CALM2 CALM3
20	Cushing syndrome ³⁷ Show member pathways Melanogenesis ³⁷	12.27	CALM1 CALM2 CALM3 POMC
21	Oocyte meiosis ³⁷ Show member pathways Progesterone-mediated oocyte maturation ³⁷	12.26	CALM1 CALM2 CALM3
22	Immune response CCR3 signaling in eosinophils ²² Show member pathways Inhibitory action of Lipoxins on neutrophil migration ²²	12.25	CALM1 CALM2 CALM3
23	Metabolism of fat-soluble vitamins ⁶⁶ Show member pathways Metabolism of vitamin K ⁶⁶ Retinoid metabolism and transport ⁶⁶ The retinoid cycle in cones (daylight vision) ⁶⁶ Visual phototransduction ⁶⁶ Vitamin D (calciferol) metabolism ⁶⁶	12.24	CALM1 CALM2 CALM3
24	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.23	CALM1 CALM2 CALM3
25	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways T Cell Receptor Signaling Pathway ⁶⁷	12.23	CALM1 CALM2 CALM3
26	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.22	CALM1 CALM2 CALM3
27	cAMP signaling pathway ³⁷ Show member pathways Hydroxycarboxylic acid-binding receptors ⁶⁶	12.2	CALM1 CALM2 CALM3
28	Platelet homeostasis ⁶⁶ Show member pathways Elevation of cytosolic Ca2+ levels ⁶⁶ Platelet calcium homeostasis ⁶⁶ Platelet sensitization by LDL ⁶⁶ Prostacyclin signalling through prostacyclin receptor ⁶⁶ Reduction of cytosolic Ca++ levels ⁶⁶	12.17	CALM1 CALM2 CALM3
29	Calcium signaling pathway ³⁷ Show member pathways Oxytocin signaling ¹	12.16	CALM1 CALM2 CALM3
30	Post NMDA receptor activation events ⁶⁶ Show member pathways Activation of CaMK IV ⁶⁶ Activation of NMDA receptor upon glutamate binding and postsynaptic events ⁶⁶ CaMK IV-mediated phosphorylation of CREB ⁶⁶ CREB phosphorylation through the activation of CaMKII ⁶⁶ CREB phosphorylation through the activation of CaMKK ⁶⁶ CREB phosphorylation through the activation of Ras ⁶⁶ Ras activation uopn Ca2+ infux through NMDA receptor ⁶⁶ RSK activation ⁶⁶ Unblocking of NMDA receptor, glutamate binding and activation ⁶⁶	12.15	CALM1 CALM2 CALM3
31	Tuberculosis ³⁷	12.14	CALM1 CALM2 CALM3
32	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ VEGFR2 mediated vascular permeability ⁶⁶	12.12	CALM1 CALM2 CALM3
33	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.11	CALM1 CALM2 CALM3
34	Long-term potentiation ³⁷ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁵	12.09	CALM1 CALM2 CALM3
35	Salivary secretion ³⁷ Show member pathways Gastric acid secretion ³⁷	12.09	CALM1 CALM2 CALM3
36	ADP signalling through P2Y purinoceptor 1 ⁶⁶ Show member pathways Development Angiotensin signaling via beta-Arrestin ²² Signal amplification ⁶⁶ Thrombin signalling through proteinase activated receptors (PARs) ⁶⁶ Thromboxane signalling through TP receptor ⁶⁶	12.07	CALM1 CALM2 CALM3
37	Cellular senescence (KEGG) ³⁷	12.07	CALM1 CALM2 CALM3
38	Phototransduction ³⁷ Show member pathways Activation of the phototransduction cascade ⁶⁶ Inactivation, recovery and regulation of the phototransduction cascade ⁶⁶ The phototransduction cascade ⁶⁶ Visual signal transduction- Cones ¹ Visual signal transduction- Rods ¹	12.06	CALM1 CALM2 CALM3
39	Immune response Function of MEF2 in T lymphocytes ²² Show member pathways Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis ²²	12.03	CALM1 CALM2 CALM3
40	Fluid shear stress and atherosclerosis ³⁷	12	CALM1 CALM2 CALM3
41	Apelin signaling pathway ³⁷	11.99	CALM1 CALM2 CALM3
42	Translation Translation regulation by Alpha-1 adrenergic receptors ²² Show member pathways Development Activation of ERK by Alpha-1 adrenergic receptors ²²	11.93	CALM1 CALM2 CALM3
43	Amphetamine addiction ³⁷ Show member pathways Cocaine addiction ³⁷	11.91	CALM1 CALM2 CALM3
44	Inositol phosphate metabolism ⁶⁶ Show member pathways D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis ¹ inositol pyrophosphates biosynthesis ¹ myo-inositol de novo biosynthesis ¹ Synthesis of IP2, IP, and Ins in the cytosol ⁶⁶ Synthesis of IP3 and IP4 in the cytosol ⁶⁶ Synthesis of IPs in the nucleus ⁶⁶ Synthesis of pyrophosphates in the cytosol ⁶⁶	11.88	CALM1 CALM2 CALM3
45	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers ⁶⁶ Show member pathways B-Cell Receptor Complex ⁶⁴ CD22 mediated BCR regulation ⁶⁶ CLEC7A (Dectin-1) induces NFAT activation ⁶⁶ FCERI mediated Ca+2 mobilization ⁶⁶	11.85	CALM1 CALM2 CALM3
46	Glucagon signaling pathway ³⁷	11.84	CALM1 CALM2 CALM3
47	ErbB1 downstream signaling ¹	11.83	CALM1 CALM2 CALM3
48	Visual Cycle in Retinal Rods ⁶⁴	11.81	CALM1 CALM2 CALM3
49	Development EPO-induced Jak-STAT pathway ²² Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.8	CALM1 CALM2 CALM3
50	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.77	CALM1 CALM2 CALM3

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GO Terms for Spontaneous Ocular Nystagmus

Cellular components related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	spindle	GO:0005819	9.65	CALM1 CALM2 CALM3
2	vesicle	GO:0031982	9.63	CALM1 CALM2 CALM3
3	neuron projection	GO:0043005	9.62	CALB1 CALM1 CALM3 FRMD7
4	myelin sheath	GO:0043209	9.61	CALM1 CALM2 CALM3
5	growth cone	GO:0030426	9.58	CALM1 CALM3 FRMD7
6	spindle pole	GO:0000922	9.54	CALM1 CALM2 CALM3
7	sarcomere	GO:0030017	9.43	CALM1 CALM2 CALM3
8	spindle microtubule	GO:0005876	9.33	CALM1 CALM2 CALM3
9	calcium channel complex	GO:0034704	9.13	CALM1 CALM2 CALM3
10	catalytic complex	GO:1902494	8.8	CALM1 CALM2 CALM3

Biological processes related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

(show all 31)

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium-mediated signaling	GO:0019722	9.79	CALM1 CALM2 CALM3
2	response to calcium ion	GO:0051592	9.77	CALM1 CALM2 CALM3
3	regulation of synaptic vesicle exocytosis	GO:2000300	9.77	CALM1 CALM3 CSPG5
4	positive regulation of protein serine/threonine kinase activity	GO:0071902	9.76	CALM1 CALM2 CALM3
5	substantia nigra development	GO:0021762	9.75	CALM1 CALM2 CALM3
6	regulation of cytokinesis	GO:0032465	9.74	CALM1 CALM2 CALM3
7	regulation of heart rate	GO:0002027	9.72	CALM1 CALM2 CALM3
8	positive regulation of peptidyl-threonine phosphorylation	GO:0010800	9.71	CALM1 CALM2 CALM3
9	positive regulation of protein dephosphorylation	GO:0035307	9.7	CALM1 CALM2 CALM3
10	positive regulation of protein autophosphorylation	GO:0031954	9.69	CALM1 CALM2 CALM3
11	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	GO:0010881	9.67	CALM1 CALM2 CALM3
12	response to amphetamine	GO:0001975	9.65	CALM1 CALM3
13	activation of adenylate cyclase activity	GO:0007190	9.65	CALM1 CALM3
14	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO:0010880	9.65	CALM1 CALM2 CALM3
15	positive regulation of DNA binding	GO:0043388	9.64	CALM2 CALM3
16	positive regulation of nitric-oxide synthase activity	GO:0051000	9.64	CALM1 CALM3
17	response to corticosterone	GO:0051412	9.63	CALM1 CALM3
18	regulation of ryanodine-sensitive calcium-release channel activity	GO:0060314	9.63	CALM1 CALM3
19	regulation of cardiac muscle contraction	GO:0055117	9.63	CALM1 CALM2 CALM3
20	regulation of synaptic vesicle endocytosis	GO:1900242	9.62	CALM1 CALM3
21	establishment of protein localization to membrane	GO:0090150	9.62	CALM1 CALM3
22	regulation of high voltage-gated calcium channel activity	GO:1901841	9.61	CALM1 CALM3
23	negative regulation of peptidyl-threonine phosphorylation	GO:0010801	9.61	CALM1 CALM2 CALM3
24	positive regulation of phosphoprotein phosphatase activity	GO:0032516	9.58	CALM1 CALM2 CALM3
25	establishment of protein localization to mitochondrial membrane	GO:0090151	9.56	CALM1 CALM3
26	detection of calcium ion	GO:0005513	9.54	CALM1 CALM2 CALM3
27	negative regulation of ryanodine-sensitive calcium-release channel activity	GO:0060315	9.5	CALM1 CALM2 CALM3
28	positive regulation of ryanodine-sensitive calcium-release channel activity	GO:0060316	9.43	CALM1 CALM2 CALM3
29	regulation of cell communication by electrical coupling involved in cardiac conduction	GO:1901844	9.33	CALM1 CALM2 CALM3
30	positive regulation of cyclic-nucleotide phosphodiesterase activity	GO:0051343	9.13	CALM1 CALM2 CALM3
31	positive regulation by host of symbiont cAMP-mediated signal transduction	GO:0075206	8.8	CALM1 CALM2 CALM3

Molecular functions related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium ion binding	GO:0005509	9.86	CALB1 CALM1 CALM2 CALM3
2	protein domain specific binding	GO:0019904	9.76	CALM1 CALM2 CALM3 MED12
3	ion channel binding	GO:0044325	9.69	CALM1 CALM2 CALM3
4	disordered domain specific binding	GO:0097718	9.61	CALM1 CALM2 CALM3
5	enzyme regulator activity	GO:0030234	9.55	CALM1 CALM3
6	phosphatidylinositol 3-kinase binding	GO:0043548	9.54	CALM1 CALM3
7	protein serine/threonine kinase activator activity	GO:0043539	9.54	CALM1 CALM2 CALM3
8	nitric-oxide synthase binding	GO:0050998	9.52	CALM1 CALM3
9	titin binding	GO:0031432	9.5	CALM1 CALM2 CALM3
10	calcium channel inhibitor activity	GO:0019855	9.49	CALM1 CALM2
11	nitric-oxide synthase regulator activity	GO:0030235	9.48	CALM1 CALM3
12	adenylate cyclase binding	GO:0008179	9.43	CALM1 CALM2 CALM3
13	type 3 metabotropic glutamate receptor binding	GO:0031800	9.4	CALM1 CALM3
14	protein phosphatase activator activity	GO:0072542	9.33	CALM1 CALM2 CALM3
15	adenylate cyclase activator activity	GO:0010856	9.13	CALM1 CALM2 CALM3
16	N-terminal myristoylation domain binding	GO:0031997	8.8	CALM1 CALM2 CALM3

Sources

Sources for Spontaneous Ocular Nystagmus

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia