MCID: SPN033
MIFTS: 25

Spontaneous Ocular Nystagmus

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Spontaneous Ocular Nystagmus

MalaCards integrated aliases for Spontaneous Ocular Nystagmus:

Name: Spontaneous Ocular Nystagmus 12 15 71
Visual Deprivation Nystagmus 12
Searching Eye Movements 12
Nystagmus, Pathologic 43
Ocular Nystagmus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11771
ICD9CM 34 379.53
MeSH 43 D009759
SNOMED-CT 67 39771000 45339001
ICD10 32 H55.03
UMLS 71 C0271384

Summaries for Spontaneous Ocular Nystagmus

MalaCards based summary : Spontaneous Ocular Nystagmus, also known as visual deprivation nystagmus, is related to pathologic nystagmus and ataxia and polyneuropathy, adult-onset, and has symptoms including deficiencies of smooth pursuit movements An important gene associated with Spontaneous Ocular Nystagmus is FRMD7 (FERM Domain Containing 7). The drugs Dopamine and Memantine have been mentioned in the context of this disorder. Affiliated tissues include eye.

Related Diseases for Spontaneous Ocular Nystagmus

Diseases related to Spontaneous Ocular Nystagmus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 pathologic nystagmus 30.0 MED12 FRMD7
2 ataxia and polyneuropathy, adult-onset 9.9
3 schizophrenia 9.9
4 mood disorder 9.9
5 neurotic disorder 9.9
6 papillon-lefevre syndrome 9.8
7 vestibular nystagmus 9.8
8 lateral medullary syndrome 9.8
9 congenital nystagmus 9.7
10 vestibular neuronitis 9.7 RTEL1 CMTR2
11 vestibulocochlear nerve disease 9.7 RTEL1 CMTR2
12 benign paroxysmal positional nystagmus 9.6 RTEL1 CMTR2
13 inner ear disease 9.4 RTEL1 CMTR2

Graphical network of the top 20 diseases related to Spontaneous Ocular Nystagmus:



Diseases related to Spontaneous Ocular Nystagmus

Symptoms & Phenotypes for Spontaneous Ocular Nystagmus

UMLS symptoms related to Spontaneous Ocular Nystagmus:


deficiencies of smooth pursuit movements

Drugs & Therapeutics for Spontaneous Ocular Nystagmus

Drugs for Spontaneous Ocular Nystagmus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Memantine Approved, Investigational Phase 4 19982-08-2 4054
3
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5 Anti-Anxiety Agents Phase 4
6 Analgesics Phase 4
7 Neurotransmitter Agents Phase 4
8 Tranquilizing Agents Phase 4
9 Dopamine Agents Phase 4
10 Psychotropic Drugs Phase 4
11 Anticonvulsants Phase 4
12 Antiparkinson Agents Phase 4
13 Antimanic Agents Phase 4
14 Central Nervous System Depressants Phase 4
15 Excitatory Amino Acid Antagonists Phase 4
16 Excitatory Amino Acids Phase 4
17 Pharmaceutical Solutions Phase 4
18 Ophthalmic Solutions Phase 4
19 Carbonic Anhydrase Inhibitors Phase 4
20
4-Aminopyridine Approved Phase 1, Phase 2 504-24-5 1727
21 Potassium Channel Blockers Phase 1, Phase 2
22 Kava Approved, Investigational, Nutraceutical 9000-38-8

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Oculopalatal Tremor: a Controled Open-label Study Completed NCT02466191 Phase 4 Memantine;Gabapentin
2 Topical Brinzolamide Ophthalmic Suspension Versus Placebo in the Treatment of Infantile Nystagmus Syndrome Completed NCT01312402 Phase 4 topical brinzolamide 1% in 5mL ophthalmic medication;Placebo in 5 mL dispenser
3 Phase 2 Study of 4-Aminopyridine for the Treatment of Episodic Ataxia Type 2 Unknown status NCT01543750 Phase 2 4-Aminopyridine;Placebo
4 Efficacy and Safety of Neramexane Mesylate in Congenital Idiopathic Nystagmus and Acquired Nystagmus: a Randomized, Double-blind, Placebo-controlled, Single Center, Proof of Concept Study Using a Two-period Cross-over Design Completed NCT00661440 Phase 2 Neramexane mesylate
5 Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Multiple Sclerosis Completed NCT01744444 Phase 2 Memantine;Gabapentin
6 Horizontal Rectus Tenotomy in the Treatment of Congenital Nystagmus Completed NCT00001866 Phase 2
7 A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma Not yet recruiting NCT04026568 Phase 1, Phase 2 4-Aminopyridine;Placebo oral tablet
8 Long-term Open-label Extension Study to Assess the Safety, Tolerability, and Efficacy of Neramexane Mesylate in Congenital Idiopathic Nystagmus and Acquired Nystagmus Terminated NCT00799942 Phase 2 Neramexane mesylate
9 Effects of Vestibular Rehabilitation in the Treatment of Patients With Acute Vestibular Loss. - A Randomized Controlled Trial Completed NCT00702832
10 Investigation and Treatment of Ocular Motor Disorders: Cross-over Comparison of Gabapentin and Memantine as Treatment for Nystagmus Completed NCT00928954 gabapentin;memantine
11 Screening Study for the Evaluation and Diagnosis of Potential Research Subjects With Nystagmus or Strabismus Completed NCT00001861
12 Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Healthy Volunteer Trial Completed NCT03661762
13 Coordination of Rare Diseases at Sanford Recruiting NCT01793168
14 Biofeedback in Idiopathic Infantile Nystagmus Syndrome Recruiting NCT04142307

Search NIH Clinical Center for Spontaneous Ocular Nystagmus

Cochrane evidence based reviews: nystagmus, pathologic

Genetic Tests for Spontaneous Ocular Nystagmus

Anatomical Context for Spontaneous Ocular Nystagmus

MalaCards organs/tissues related to Spontaneous Ocular Nystagmus:

40
Eye

Publications for Spontaneous Ocular Nystagmus

Articles related to Spontaneous Ocular Nystagmus:

(show all 12)
# Title Authors PMID Year
1
Temporal changes of calbindin expression in the nodulus following unilateral labyrinthectomy in rats. 61
24055607 2013
2
The role of tonic vestibular input for postural control in rats. 61
9177127 1997
3
Evidence that short ACTH fragments enhance vestibular compensation via direct action on the ipsilateral vestibular nucleus. 61
8856704 1996
4
Early diazepam treatment following unilateral labyrinthectomy does not impair vestibular compensation of spontaneous nystagmus in guinea pig. 61
8925116 1996
5
Methylprednisolone reduces spontaneous nystagmus following unilateral labyrinthectomy in guinea pig. 61
7768297 1995
6
Ginkgolide B accelerates vestibular compensation of spontaneous ocular nystagmus in guinea pig following unilateral labyrinthectomy. 61
7895826 1995
7
A dose-response analysis of the beneficial effects of the ACTH-(4-9) analogue, Org 2766, on behavioural recovery following unilateral labyrinthectomy in guinea-pig. 61
8012719 1994
8
Evidence that L-type calcium channels do not contribute to static vestibular function in the guinea pig vestibular nucleus. 61
7509710 1993
9
Middle ear procaine injection before surgical labyrinthectomy reduces nystagmus. 61
8260619 1993
10
Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs. 61
8491266 1993
11
Pretreatment with MK-801 reduces spontaneous nystagmus following unilateral labyrinthectomy. 61
1330616 1992
12
Pre-treatment with a Ca2+ channel antagonist facilitates vestibular compensation. 61
1623162 1992

Variations for Spontaneous Ocular Nystagmus

Expression for Spontaneous Ocular Nystagmus

Search GEO for disease gene expression data for Spontaneous Ocular Nystagmus.

Pathways for Spontaneous Ocular Nystagmus

GO Terms for Spontaneous Ocular Nystagmus

Cellular components related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 8.8 GRIN2A FRMD7 CALB1

Biological processes related to Spontaneous Ocular Nystagmus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 learning or memory GO:0007611 8.96 GRIN2A CALB1
2 regulation of synaptic plasticity GO:0048167 8.62 GRIN2A CALB1

Sources for Spontaneous Ocular Nystagmus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....