MCID: SPR009
MIFTS: 50

Sporadic Breast Cancer

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Immune diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Sporadic Breast Cancer

MalaCards integrated aliases for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 12 15
Sporadic Breast Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8029
NCIt 50 C7566
UMLS 73 C1336076

Summaries for Sporadic Breast Cancer

Disease Ontology : 12 A breast carcinoma that occurs in people who do not have a family history of that cancer or an inherited change in their DNA that would increase their risk for that cancer.

MalaCards based summary : Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to cowden disease and peutz-jeghers syndrome. An important gene associated with Sporadic Breast Cancer is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are ERK Signaling and Gene Expression. Affiliated tissues include breast, lung and skin, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Sporadic Breast Cancer

Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
Sporadic Breast Cancer Breast Carcinoma in Situ

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 cowden disease 30.1 BRCA1 BRCA2 PTEN
2 peutz-jeghers syndrome 29.9 BRCA2 PTEN TP53
3 mutagen sensitivity 29.8 BRCA1 BRCA2 TP53 XRCC1
4 xeroderma pigmentosum, variant type 29.6 ATM RAD51 TP53 XRCC1
5 breast cancer 29.3 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
6 breast disease 29.1 BRCA1 BRCA2 ERBB2 ESR1 ESR2 PGR
7 bilateral breast cancer 29.1 ATM BRCA1 BRCA2 CHEK2 ERBB2 FHIT
8 ovarian cancer 28.2 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
9 hereditary site-specific ovarian cancer syndrome 10.3 BRCA1 BRCA2
10 breast reconstruction 10.3 BRCA1 BRCA2
11 vestibular gland benign neoplasm 10.3 ESR1 PGR
12 bartholin's gland adenoma 10.3 ESR1 PGR
13 vulvar syringoma 10.3 ESR1 PGR
14 lung leiomyoma 10.3 ESR1 PGR
15 vulvar benign neoplasm 10.2 ESR1 PGR
16 endometrium carcinoma in situ 10.2 PGR TP53
17 trigonitis 10.2 ESR1 PGR
18 vulvar leiomyoma 10.2 ESR1 PGR
19 predominantly cortical thymoma 10.2 ESR1 PGR
20 nosophobia 10.2 BRCA1 BRCA2 PGR
21 cancerophobia 10.2 BRCA1 BRCA2 PGR
22 breast-ovarian cancer, familial 1 10.2 BRCA1 BRCA2
23 bartholin's gland benign neoplasm 10.2 ESR1 PGR
24 oncocytic breast carcinoma 10.2 ESR1 PGR
25 scirrhous adenocarcinoma 10.2 ERBB2 PGR
26 breast apocrine carcinoma 10.2 ERBB2 PGR
27 postmenopausal atrophic vaginitis 10.2 ESR1 ESR2
28 gastric papillary adenocarcinoma 10.2 ERBB2 TP53
29 dysgerminoma of ovary 10.2 BRCA1 BRCA2 PGR
30 comedo carcinoma 10.2 ERBB2 ESR1
31 papillary serous adenocarcinoma 10.2 BRCA1 PGR TP53
32 tuberculous salpingitis 10.2 BRCA1 BRCA2 ERBB2
33 intracystic papillary adenoma 10.2 ERBB2 PGR
34 fallopian tube adenocarcinoma 10.2 BRCA1 BRCA2 ERBB2
35 breast metaplastic carcinoma 10.2 ERBB2 PGR
36 cervical carcinosarcoma 10.2 ESR1 PGR TP53
37 progesterone resistance 10.2 ESR1 ESR2 PGR
38 breast duct papilloma 10.2 PGR PTEN
39 adenosarcoma 10.2 ESR1 PGR TP53
40 gender identity disorder 10.2 ESR1 ESR2 PGR
41 li-fraumeni syndrome 2 10.2 CHEK2 TP53
42 estrogen excess 10.2 ESR1 ESR2 PGR
43 breast malignant phyllodes tumor 10.2 PGR TP53
44 endometriosis of ovary 10.2 ESR1 ESR2 PGR
45 progesterone-receptor negative breast cancer 10.2 ERBB2 PGR
46 uterine corpus serous adenocarcinoma 10.2 BRCA1 ERBB2 TP53
47 endometrial squamous cell carcinoma 10.2 ESR1 PGR
48 glassy cell carcinoma of the cervix 10.2 ERBB2 ESR1 PGR
49 pleomorphic adenoma carcinoma 10.2 ERBB2 TP53
50 cribriform carcinoma 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to Sporadic Breast Cancer

Symptoms & Phenotypes for Sporadic Breast Cancer

GenomeRNAi Phenotypes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.72 BARD1 BRCA1 RAD51
2 Decreased homologous recombination repair frequency GR00151-A-2 10.72 BRCA1 RAD51
3 Decreased homologous recombination repair frequency GR00236-A-1 10.72 BARD1 BRCA1 BRCA2 PGR RAD51
4 Decreased homologous recombination repair frequency GR00236-A-2 10.72 ATM BARD1 BRCA1 BRCA2 PGR RAD51
5 Decreased homologous recombination repair frequency GR00236-A-3 10.72 BARD1 BRCA1 BRCA2 RAD51
6 Decreased viability GR00221-A-2 10.28 BRCA1 CHEK2
7 Decreased viability GR00221-A-3 10.28 ATM BRCA1 CHEK2 ERBB2
8 Decreased viability GR00221-A-4 10.28 ATM CHEK2 ERBB2
9 Decreased viability GR00301-A 10.28 BRCA1
10 Decreased viability GR00342-S-2 10.28 CHEK2
11 Decreased viability GR00402-S-2 10.28 ATM BRCA1 CHEK2 ERBB2
12 Decreased ionizing radiation sensitivity GR00232-A-1 10.03 ATM BARD1 BRCA1 BRCA2 ESR2 FANCD2
13 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
14 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
15 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.81 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
16 Increased cell death HMECs cells GR00103-A-0 9.73 BRCA1 PGR PTEN RAD51 TP53 TTC4
17 Decreased viability with cisplatin GR00101-A-4 9.62 BARD1 BRCA1 BRCA2 RAD51
18 Decreased viability after ionizing radiation GR00232-A-2 9.54 ATM BRCA1 BRCA2
19 Synthetic lethal with cisplatin GR00101-A-1 9.26 BARD1 BRCA1 BRCA2 RAD51

MGI Mouse Phenotypes related to Sporadic Breast Cancer:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
2 behavior/neurological MP:0005386 10.32 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
3 homeostasis/metabolism MP:0005376 10.31 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
4 growth/size/body region MP:0005378 10.3 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1
5 embryo MP:0005380 10.29 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1
6 endocrine/exocrine gland MP:0005379 10.28 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
7 mortality/aging MP:0010768 10.28 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
8 hematopoietic system MP:0005397 10.25 ATM BRCA1 BRCA2 CHEK2 ESR1 ESR2
9 immune system MP:0005387 10.22 ATM BRCA1 BRCA2 CHEK2 ESR1 ESR2
10 neoplasm MP:0002006 10.17 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
11 digestive/alimentary MP:0005381 10.16 BRCA1 BRCA2 ERBB2 ESR1 ESR2 FHIT
12 integument MP:0010771 10.16 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
13 limbs/digits/tail MP:0005371 10.09 BRCA1 BRCA2 ERBB2 ESR1 ESR2 FANCD2
14 adipose tissue MP:0005375 10.06 ATM BRCA1 ESR1 ESR2 PTEN TP53
15 nervous system MP:0003631 10.03 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
16 muscle MP:0005369 9.91 BRCA1 ERBB2 ESR1 ESR2 PGR PTEN
17 normal MP:0002873 9.85 BARD1 BRCA1 BRCA2 ERBB2 ESR1 ESR2
18 reproductive system MP:0005389 9.65 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
19 skeleton MP:0005390 9.23 BRCA1 BRCA2 ERBB2 ESR1 ESR2 PGR

Drugs & Therapeutics for Sporadic Breast Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Syndrome as Modifiable Risk Factor for Breast Cancer Unknown status NCT01172886
2 Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers Active, not recruiting NCT02087592 Not Applicable

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

Anatomical Context for Sporadic Breast Cancer

MalaCards organs/tissues related to Sporadic Breast Cancer:

41
Breast, Lung, Skin, Brain, Bone, Pancreas, Thyroid

Publications for Sporadic Breast Cancer

Articles related to Sporadic Breast Cancer:

(show top 50) (show all 270)
# Title Authors Year
1
Genetic determinants of sporadic breast cancer in Sri Lankan women. ( 29433565 )
2018
2
Association analysis of interleukin-18 gene promoter region polymorphisms and susceptibility to sporadic breast cancer in Chinese Han women. ( 29926984 )
2018
3
Distinct role of endothelial nitric oxide synthase gene polymorphisms from menopausal status in the patients with sporadic breast cancer in Taiwan. ( 29102546 )
2018
4
Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features. ( 29453630 )
2018
5
Genetic Variants Associated with Clinicopathological Profiles in Sporadic Breast Cancer in Sri Lankan Women. ( 29963112 )
2018
6
CHEK2 Germ Line Mutations are Lacking among Familial and Sporadic Breast Cancer Patients in Rwanda ( 29479983 )
2018
7
EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer. ( 29661238 )
2018
8
ERCC5 rs751402 polymorphism is the risk factor for sporadic breast cancer in Thailand. ( 30245779 )
2018
9
BRCA1 Promoter Methylation and Clinicopathological Characteristics in Sporadic Breast Cancer Patients in Indonesia ( 30256562 )
2018
10
Simultaneous ATM/BRCA1/RAD51 expression variations associated with prognostic factors in Iranian sporadic breast cancer patients. ( 28058614 )
2017
11
Corrigendum to "Variants of estrogen receptor alpha and beta genes modify the severity of sporadic breast cancer" [Gene 608C (2017) 73-78]. ( 28363082 )
2017
12
Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53. ( 28630214 )
2017
13
Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. ( 28190851 )
2017
14
Can MTHFR C677T and A1298C Polymorphisms Alter the Risk and Severity of Sporadic Breast Cancer in Brazilian Women? ( 28330681 )
2017
15
Variants of estrogen receptor alpha and beta genes modify the severity of sporadic breast cancer. ( 28109853 )
2017
16
Computational Investigation of Homologous Recombination DNA Repair Deficiency in Sporadic Breast Cancer. ( 29146938 )
2017
17
TGFbeta and miRNA regulation in familial and sporadic breast cancer. ( 28881597 )
2017
18
Cost-effectiveness Analysis of Contralateral Prophylactic Mastectomy Compared to Unilateral Mastectomy with Routine Surveillance for Unilateral, Sporadic Breast Cancer. ( 29039025 )
2017
19
Contralateral risk reducing mastectomy in patients with sporadic breast cancer. Benefits and hazards. ( 27189832 )
2016
20
A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility. ( 27668787 )
2016
21
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility. ( 26650628 )
2016
22
Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer. ( 26723934 )
2016
23
A study on promoter methylation of PTEN in sporadic breast cancer patients from North India. ( 26754093 )
2016
24
Association between genetic variants of EGF-containing fibulin-like extracellular matrix protein1 gene and sporadic breast cancer in a Chinese Han population. ( 27048115 )
2016
25
Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients. ( 26205471 )
2016
26
Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients. ( 27413552 )
2016
27
Differential Cytotoxicity, Cellular Uptake, Apoptosis and Inhibition of BRCA1 Expression of BRCA1-Defective and Sporadic Breast Cancer Cells Induced by an Anticancer Ruthenium(II)-Arene Compound, RAPTA-EA1. ( 27039925 )
2016
28
Promoter methylation and expression changes of BRCA1 in cancerous tissues of patients with sporadic breast cancer. ( 25789047 )
2015
29
Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China. ( 26535628 )
2015
30
A novel BRCA2 in frame deletion in a Tunisian woman with early onset sporadic breast cancer. ( 26320393 )
2015
31
Development and validation of molecular methodologies to assess PALB2 expression in sporadic breast cancer. ( 26526077 )
2015
32
Assessing Heavy Metal and PCB Exposure from Tap Water by Measuring Levels in Plasma from Sporadic Breast Cancer Patients, a Pilot Study. ( 26690196 )
2015
33
Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer. ( 26430163 )
2015
34
Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study. ( 26476291 )
2015
35
Decreased Expression of BRCA2 Accelerates Sporadic Breast Cancer Progression. ( 27065665 )
2015
36
First description of a sporadic breast cancer in a woman with BRCA1 germline mutation. ( 26426992 )
2015
37
Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women. ( 26598080 )
2015
38
DNA repair genes XRCC1 and ERCC1 polymorphisms and the risk of sporadic breast cancer in Han women in the Gansu Province of China. ( 25961110 )
2015
39
Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer. ( 26456802 )
2015
40
ATM gene mutations in sporadic breast cancer patients from Brazil. ( 25625042 )
2015
41
The CHEK2 1100delC allelic variant is not present in familial and sporadic breast cancer cases from Moroccan population. ( 25674498 )
2015
42
Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. ( 24556691 )
2014
43
Association of TNF-I+, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of sporadic breast cancer in northeast Chinese Han women. ( 25010932 )
2014
44
A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival. ( 25067956 )
2014
45
The promoter methylation status and mRNA expression levels of CTCF and SIRT6 in sporadic breast cancer. ( 24842653 )
2014
46
Association of +405C>G and +936C>T polymorphisms of the vascular endothelial growth factor gene with sporadic breast cancer in North Indians. ( 24528036 )
2014
47
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis. ( 24464625 )
2014
48
Association of promoter methylation of ERI+ and ERI^ with sporadic breast cancer--a study from North India. ( 24833090 )
2014
49
The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients. ( 24850984 )
2014
50
BRCA1 gene exon 11 mutations in Uighur and Han women with early-onset sporadic breast cancer in the northwest region of China. ( 24969878 )
2014

Variations for Sporadic Breast Cancer

Expression for Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for Sporadic Breast Cancer

Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 ATM BRCA1 CHEK2 ERBB2 ESR1 ESR2
2
Show member pathways
13.79 ATM BARD1 BRCA1 CHEK2 ERBB2 ESR1
3
Show member pathways
13.4 ATM BARD1 BRCA1 BRCA2 CHEK2 RAD51
4
Show member pathways
13.2 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
5
Show member pathways
12.96 ATM BARD1 BRCA1 CHEK2 FANCD2 PTEN
6
Show member pathways
12.92 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
7
Show member pathways
12.84 BRCA2 ERBB2 PTEN RAD51 TP53
8 12.83 BRCA2 ERBB2 ESR1 ESR2 PTEN RAD51
9
Show member pathways
12.81 BARD1 BRCA1 ESR1 PTEN TP53
10
Show member pathways
12.79 BRCA1 BRCA2 ERBB2 ESR1 ESR2 PGR
11
Show member pathways
12.78 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
12
Show member pathways
12.63 ATM BARD1 BRCA1 CHEK2 TP53
13 12.55 ATM BRCA1 BRCA2 CHEK2 FANCD2 RAD51
14 12.52 ATM BRCA1 ERBB2 PTEN TP53
15
Show member pathways
12.5 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
16
Show member pathways
12.47 ATM BRCA1 BRCA2 RAD51
17
Show member pathways
12.46 ERBB2 ESR1 ESR2 PTEN
18
Show member pathways
12.42 ATM CHEK2 ERBB2 TP53
19
Show member pathways
12.42 ATM BRCA1 CHEK2 FANCD2 PTEN RAD51
20
Show member pathways
12.38 ATM BARD1 BRCA1 CHEK2 TP53
21
Show member pathways
12.3 ATM BARD1 BRCA1 BRCA2 RAD51
22
Show member pathways
12.26 ATM BRCA1 CHEK2 PTEN TP53
23
Show member pathways
12.22 BRCA1 CHEK2 ESR1 PGR
24 12.16 ATM CHEK2 PTEN TP53
25
Show member pathways
12.16 ATM BARD1 BRCA1 BRCA2 RAD51
26 11.99 ATM ERBB2 PTEN TP53
27
Show member pathways
11.92 ERBB2 ESR1 PGR
28
Show member pathways
11.91 ATM BRCA1 CHEK2 FANCD2 RAD51 TP53
29 11.9 BRCA1 BRCA2 FANCD2 RAD51
30 11.85 FHIT PTEN TP53
31
Show member pathways
11.83 ESR1 ESR2 PGR
32 11.8 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
33 11.76 ATM BRCA1 ERBB2 TP53
34 11.73 ATM BRCA1 XRCC1
35 11.73 ATM BRCA1 CHEK2 ERBB2 PTEN TP53
36
Show member pathways
11.72 ATM CHEK2 TP53
37 11.67 ERBB2 PTEN TP53
38 11.63 ATM CHEK2 TP53
39 11.54 ATM BARD1 BRCA1 CHEK2 PTEN TP53
40 11.53 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
41
Show member pathways
11.49 ATM CHEK2 TP53
42 11.49 ATM BARD1 BRCA1 CHEK2 FANCD2 TP53
43 11.43 BRCA2 CHEK2 ESR1 XRCC1
44 11.39 ESR1 PTEN TP53
45 11.32 ATM BRCA1 TP53
46 11.32 ATM ESR2 PGR
47 11.2 ATM BARD1 BRCA1 FANCD2 RAD51 TP53
48
Show member pathways
11.14 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
49 11.07 ATM BRCA1 TP53
50 10.37 CHEK2 TP53

GO Terms for Sporadic Breast Cancer

Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.86 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
2 nuclear chromatin GO:0000790 9.76 ESR1 RAD51 TP53 XRCC1
3 nuclear chromosome, telomeric region GO:0000784 9.67 ATM BRCA2 RAD51 XRCC1
4 condensed chromosome GO:0000793 9.58 BRCA1 FANCD2 RAD51
5 PML body GO:0016605 9.56 CHEK2 PTEN RAD51 TP53
6 nucleoplasm GO:0005654 9.47 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
7 BRCA1-A complex GO:0070531 9.43 BARD1 BRCA1
8 lateral element GO:0000800 9.33 BRCA1 BRCA2 RAD51
9 BRCA1-BARD1 complex GO:0031436 9.32 BARD1 BRCA1
10 cytoplasm GO:0005737 10.29 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.98 ATM BRCA1 ERBB2 PTEN TP53
2 regulation of apoptotic process GO:0042981 9.93 ATM BRCA1 ESR1 TP53
3 protein deubiquitination GO:0016579 9.88 BARD1 BRCA1 ESR1 PTEN TP53
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.82 ESR1 ESR2 PTEN
5 DNA recombination GO:0006310 9.81 BRCA1 BRCA2 RAD51
6 response to estradiol GO:0032355 9.81 BRCA2 ESR1 PTEN
7 regulation of signal transduction by p53 class mediator GO:1901796 9.79 ATM CHEK2 TP53
8 double-strand break repair GO:0006302 9.77 BRCA1 BRCA2 CHEK2
9 double-strand break repair via homologous recombination GO:0000724 9.76 BRCA1 BRCA2 RAD51 XRCC1
10 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.75 ATM CHEK2 TP53
11 double-strand break repair via nonhomologous end joining GO:0006303 9.71 ATM BARD1 BRCA1 XRCC1
12 cellular response to gamma radiation GO:0071480 9.7 ATM CHEK2 TP53
13 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.69 BRCA2 CHEK2 TP53
14 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.62 ESR1 TP53
15 telomere maintenance via recombination GO:0000722 9.62 BRCA2 RAD51
16 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.62 ATM BRCA1 BRCA2 CHEK2
17 DNA damage induced protein phosphorylation GO:0006975 9.61 ATM CHEK2
18 DNA double-strand break processing GO:0000729 9.61 ATM BARD1 BRCA1
19 DNA repair GO:0006281 9.61 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
20 protein K6-linked ubiquitination GO:0085020 9.6 BARD1 BRCA1
21 chordate embryonic development GO:0043009 9.56 BRCA1 BRCA2
22 response to gamma radiation GO:0010332 9.56 BRCA2 CHEK2 FANCD2 TP53
23 replicative senescence GO:0090399 9.54 ATM CHEK2 TP53
24 mitotic recombination-dependent replication fork processing GO:1990426 9.49 BRCA2 RAD51
25 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.46 BRCA1 BRCA2 CHEK2 TP53
26 cellular response to DNA damage stimulus GO:0006974 9.32 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
27 apoptotic process GO:0006915 10.04 ATM BRCA1 CHEK2 FHIT PTEN TP53
28 cell cycle GO:0007049 10.02 ATM BRCA1 BRCA2 CHEK2 FANCD2 TP53
29 positive regulation of transcription, DNA-templated GO:0045893 10.01 BRCA1 BRCA2 CHEK2 ESR1 ESR2 TP53

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.89 CHEK2 ESR1 PTEN RHOBTB2 TP53
2 nucleotide binding GO:0000166 9.88 ATM CHEK2 ERBB2 FHIT RAD51
3 lipid binding GO:0008289 9.83 ESR1 ESR2 PGR PTEN
4 ubiquitin protein ligase binding GO:0031625 9.81 BRCA1 CHEK2 FHIT TP53
5 steroid hormone receptor activity GO:0003707 9.63 ESR1 ESR2 PGR
6 nuclear receptor activity GO:0004879 9.58 ESR1 ESR2 PGR
7 enzyme binding GO:0019899 9.56 BRCA1 ESR1 ESR2 PGR PTEN RAD51
8 steroid binding GO:0005496 9.5 ESR1 ESR2 PGR
9 estrogen receptor activity GO:0030284 9.43 ESR1 ESR2
10 estrogen response element binding GO:0034056 9.37 ESR1 ESR2
11 identical protein binding GO:0042802 9.36 BRCA1 BRCA2 CHEK2 ERBB2 ESR1 ESR2
12 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 9.26 ESR1 ESR2
13 DNA binding GO:0003677 10.14 ATM BRCA1 BRCA2 ESR1 ESR2 PGR
14 protein binding GO:0005515 10.11 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY

Sources for Sporadic Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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