MCID: SPR009
MIFTS: 42

Sporadic Breast Cancer

Categories: Cancer diseases, Genetic diseases, Immune diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Sporadic Breast Cancer

MalaCards integrated aliases for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 12 15
Sporadic Breast Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:8029
NCIt 50 C7566
UMLS 70 C1336076

Summaries for Sporadic Breast Cancer

Disease Ontology : 12 A breast carcinoma that occurs in people who do not have a family history of that cancer or an inherited change in their DNA that would increase their risk for that cancer.

MalaCards based summary : Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to familial ovarian cancer and fanconi anemia, complementation group d2. An important gene associated with Sporadic Breast Cancer is BRCA1 (BRCA1 DNA Repair Associated), and among its related pathways/superpathways are ERK Signaling and Gene Expression. Affiliated tissues include breast, prostate and endothelial, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Sporadic Breast Cancer

Diseases in the Breast Cancer family:

Inflammatory Breast Carcinoma Sporadic Breast Cancer
Breast Carcinoma in Situ

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 274)
# Related Disease Score Top Affiliating Genes
1 familial ovarian cancer 30.7 ESR1 BRCA2 BRCA1
2 fanconi anemia, complementation group d2 30.6 RAD51 FANCD2 BRCA2
3 mutagen sensitivity 30.6 XRCC1 TP53 BRCA2 BRCA1
4 breast-ovarian cancer, familial 2 30.5 BRCA2 BRCA1
5 breast fibroadenoma 30.4 TP53 PGR ESR1 ERBB2 BRCA1
6 in situ carcinoma 30.3 TP53 PTEN PGR ESR1 ERBB2 BRCA2
7 breast ductal carcinoma 30.3 TP53 PGR ESR2 ESR1 ERBB2 BRCA2
8 cowden syndrome 1 30.3 TP53 PTEN BRCA2 BRCA1
9 peutz-jeghers syndrome 30.2 TP53 PTEN BRCA2
10 ataxia-telangiectasia 30.1 XRCC1 TP53 PARP1 FANCD2 CHEK2 BRCA2
11 breast-ovarian cancer, familial 1 30.1 PALB2 BRCA2 BRCA1
12 ductal carcinoma in situ 30.0 TP53 PTEN PGR ESR2 ESR1 ERBB2
13 breast disease 29.9 XRCC1 TP53 PGR PARP1 FHIT ESR2
14 nijmegen breakage syndrome 29.8 TP53 RAD51 PTEN FANCD2 CHEK2 BRCA1
15 female breast cancer 29.7 XRCC1 TP53 PGR PALB2 ESR1 ERBB2
16 hereditary breast ovarian cancer syndrome 29.6 TP53 RAD51 PTEN PALB2 ERBB2 CHEK2
17 bladder cancer 29.6 XRCC1 TP53 PTEN MIR146A FHIT ERBB2
18 xeroderma pigmentosum, variant type 29.5 XRCC1 TP53 RAD51 PARP1 FANCD2 CHEK2
19 bilateral breast cancer 29.2 TP53 RAD51 PTEN PGR PALB2 FHIT
20 lynch syndrome 29.2 XRCC1 TP53 PTEN PALB2 CHEK2 BRCA2
21 cowden syndrome 29.1 TP53 PTEN PALB2 ERBB2 CHEK2 BRCA2
22 fanconi anemia, complementation group a 28.8 XRCC1 TP53 RAD51 PTEN PARP1 PALB2
23 breast cancer 28.7 XRCC1 TP53 RAD51 PTEN PGR PARP1
24 ovarian cancer 27.8 TP53 RAD51 PTEN PGR PARP1 PALB2
25 fallopian tube clear cell adenocarcinoma 10.5 BRCA2 BRCA1
26 ovary transitional cell carcinoma 10.5 BRCA2 BRCA1
27 cancerophobia 10.5 BRCA2 BRCA1
28 nosophobia 10.5 BRCA2 BRCA1
29 tetraploidy 10.4 BRCA2 BRCA1
30 bartholin's gland adenoid cystic carcinoma 10.4 PGR ESR1
31 uterine corpus adenosarcoma 10.4 PGR ESR1
32 nonmucinous bronchioloalveolar adenocarcinoma 10.4 ESR2 ESR1
33 chronic tympanitis 10.4 PGR ESR1
34 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 10.4 BRCA2 BRCA1
35 granulomatous endometritis 10.4 PGR ESR1
36 vulvar syringoma 10.4 PGR ESR1
37 hereditary site-specific ovarian cancer syndrome 10.4 BRCA2 BRCA1
38 breast duct papilloma 10.4 PTEN PGR
39 endosalpingiosis 10.4 PGR BRCA2 BRCA1
40 lung leiomyoma 10.4 PGR ESR1
41 bartholin's gland adenoma 10.4 TP53 PGR ESR1
42 bartholin's gland benign neoplasm 10.4 TP53 PGR ESR1
43 vestibular gland benign neoplasm 10.4 TP53 PGR ESR1
44 ruvalcaba syndrome 10.4 PTEN BRCA2 BRCA1
45 adult type testicular granulosa cell tumor 10.4 PGR ESR1
46 ovarian seromucinous carcinoma 10.4 TP53 PGR ESR1
47 human papillomavirus infectious disease 10.4 TP53 FHIT
48 cervical clear cell adenocarcinoma 10.4 PGR ESR1
49 postmenopausal atrophic vaginitis 10.4 ESR2 ESR1
50 bizarre leiomyoma 10.4 TP53 PGR ESR1

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to Sporadic Breast Cancer

Symptoms & Phenotypes for Sporadic Breast Cancer

GenomeRNAi Phenotypes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.4 BARD1 BRCA1 RAD51
2 Decreased homologous recombination repair frequency GR00151-A-2 10.4 BRCA1 RAD51
3 Decreased homologous recombination repair frequency GR00236-A-1 10.4 BARD1 BRCA1 BRCA2 PALB2 RAD51
4 Decreased homologous recombination repair frequency GR00236-A-2 10.4 BARD1 BRCA1 BRCA2 PALB2 RAD51
5 Decreased homologous recombination repair frequency GR00236-A-3 10.4 BARD1 BRCA1 BRCA2 PALB2 RAD51
6 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 10.18 ATM BARD1 CHEK2 TP53
7 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 10.18 ATM BARD1 BRCA1 CHEK2 FANCD2 PALB2
8 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 10.18 ATM BARD1 BRCA1 BRCA2 PALB2 RAD51
9 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.98 BARD1 BRCA1 BRCA2 FANCD2 PALB2 PTEN
10 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.98 ATM BRCA1 BRCA2 FANCD2 PALB2 PTEN
11 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.98 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
12 Decreased viability with cisplatin GR00101-A-4 9.67 BARD1 BRCA1 BRCA2 RAD51
13 Increased ionizing radiation sensitivity GR00232-A-1 9.56 ATM BARD1 BRCA1 BRCA2
14 Increased homologous recombination repair frequency GR00236-A-1 9.32 PGR
15 Increased homologous recombination repair frequency GR00236-A-2 9.32 PGR
16 Synthetic lethal with cisplatin GR00101-A-1 9.26 BARD1 BRCA1 BRCA2 RAD51

MGI Mouse Phenotypes related to Sporadic Breast Cancer:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.45 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
2 behavior/neurological MP:0005386 10.37 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
3 embryo MP:0005380 10.34 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1
4 growth/size/body region MP:0005378 10.34 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1
5 homeostasis/metabolism MP:0005376 10.33 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
6 endocrine/exocrine gland MP:0005379 10.29 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
7 hematopoietic system MP:0005397 10.26 ATM BRCA1 BRCA2 CHEK2 ESR1 ESR2
8 mortality/aging MP:0010768 10.25 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
9 immune system MP:0005387 10.21 ATM BRCA1 BRCA2 CHEK2 ESR1 ESR2
10 integument MP:0010771 10.18 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
11 digestive/alimentary MP:0005381 10.14 BRCA1 BRCA2 ERBB2 ESR1 ESR2 FHIT
12 neoplasm MP:0002006 10.13 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
13 limbs/digits/tail MP:0005371 10.07 BRCA1 BRCA2 ERBB2 ESR1 ESR2 FANCD2
14 nervous system MP:0003631 10 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
15 normal MP:0002873 9.65 BARD1 BRCA1 BRCA2 ERBB2 ESR1 ESR2
16 reproductive system MP:0005389 9.44 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2

Drugs & Therapeutics for Sporadic Breast Cancer

Search Clinical Trials , NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

Anatomical Context for Sporadic Breast Cancer

MalaCards organs/tissues related to Sporadic Breast Cancer:

40
Breast, Prostate, Endothelial, Thyroid, Lymph Node

Publications for Sporadic Breast Cancer

Articles related to Sporadic Breast Cancer:

(show top 50) (show all 903)
# Title Authors PMID Year
1
Four novel BRCA variants found in Chinese hereditary breast cancer patients by next-generation sequencing. 61
33476590 2021
2
Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy. 61
33247475 2021
3
Combined breast conservation therapy versus mastectomy for BRCA mutation carriers - A systematic review and meta-analysis. 61
33582622 2021
4
The Clinical and Pathological Profile of BRCA1 Gene Methylated Breast Cancer Women: A Meta-Analysis. 61
33808555 2021
5
Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells. 61
33468559 2021
6
Inflammation Mediates the Development of Aggressive Breast Cancer Following Radiotherapy. 61
33402361 2021
7
Discovery of novel DNA methylation biomarkers for non-invasive sporadic breast cancer detection in the Latino population. 61
33145876 2021
8
[Systematic and quality-assured early diagnosis of sporadic breast cancer : Update on screening effects and scientific studies]. 61
33492420 2021
9
Frequency of high-risk hormone receptor-positive breast cancer patients was much higher in Japanese breast cancer patients with germline BRCA1/2 mutations than in sporadic breast cancer patients. 61
33378795 2021
10
Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications. 61
33271295 2021
11
Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study. 61
33417321 2021
12
CBCRisk model to determine the risk of contralateral breast cancer in sporadic breast cancer. 61
33358405 2020
13
Characteristics of Breast Ducts in Normal-Risk and High-risk Women and Their Relationship to Ductal Cytologic Atypia. 61
32753377 2020
14
Preneoplasia of the Breast and Molecular Landscape. 61
32972772 2020
15
Predictive and prognostic value of LSP1 rs3817198 in sporadic breast cancer in northeastern population of Iran. 61
32738313 2020
16
Comparison of clinical features and oncologic outcomes between familial non-hereditary and hereditary breast cancer in Korean female patients. 61
31924417 2020
17
Genomic Diversity in Sporadic Breast Cancer in a Latin American Population. 61
33126731 2020
18
Frequency of the TP53 R337H variant in sporadic breast cancer and its impact on genomic instability. 61
33024147 2020
19
DNA Methylation and Breast Cancer Risk: An Epigenome-Wide Study of Normal Breast Tissue and Blood. 61
33113958 2020
20
Promoter Hypermethylation and Expression Changes of BRCA1 Gene in a Cohort of Sporadic Breast Cancer Cases among Pakistani Population. 61
32856871 2020
21
Clinicopathological characteristics of BRCA-associated breast cancer in Asian patients. 61
32397691 2020
22
Study of DOK4 gene expression and promoter methylation in sporadic breast cancer. 61
32386480 2020
23
Evaluation of non-coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity. 61
32346478 2020
24
EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases. 61
32580276 2020
25
Breast Conserving Surgery for BRCA Mutation Carriers-A Systematic Review. 61
32144082 2020
26
What surgical oncology providers and women with sporadic breast cancer should not forget in the decision-making about contralateral prophylactic mastectomy! 61
30698813 2020
27
Discussions about contralateral prophylactic mastectomy among surgical oncology providers and women with sporadic breast cancer: a content analysis. 61
30561744 2020
28
The Relationship between KIT Copy Number Variation, Protein Expression, and Angiogenesis in Sporadic Breast Cancer. 61
32821750 2020
29
MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia. 61
32192442 2020
30
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies. 61
31650727 2020
31
BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer. 61
32235500 2020
32
miRNA expression profiling of hereditary breast tumors from BRCA1- and BRCA2-germline mutation carriers in Brazil. 61
32087690 2020
33
Prognosis of BRCA1/2-negative breast cancer patients with HBOC risk factors compared with sporadic breast cancer patients without HBOC risk factors. 61
31926487 2020
34
Human Mammary Tumor Virus, Human Papilloma Virus, and Epstein-Barr Virus Infection Are Associated With Sporadic Breast Cancer Metastasis. 61
33281452 2020
35
Epstein-Barr Virus Infection and Increased Sporadic Breast Carcinoma Risk: A Meta-Analysis. 61
31311020 2020
36
Identification of Recurrent Variants in BRCA1 and BRCA2 across Multiple Cancers in the Chinese Population. 61
32879886 2020
37
How Computational Experiments Can Improve Our Understanding of the Genetic Architecture of Common Human Diseases. 61
32027528 2020
38
Interplay between BRCA1 and GADD45A and Its Potential for Nucleotide Excision Repair in Breast Cancer Pathogenesis. 61
32013256 2020
39
A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population. 61
32142098 2020
40
Population prevalence of individuals meeting criteria for hereditary breast and ovarian cancer testing. 61
31531966 2019
41
Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) variants and breast cancer risk in Burkina Faso. 61
31707358 2019
42
Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain). 61
31771539 2019
43
Mouse mammary tumor virus (MMTV) - like exogenous sequences are associated with sporadic but not hereditary human breast carcinoma. 61
31518337 2019
44
Association of MIR146A rs2910164 variation with a predisposition to sporadic breast cancer in a Pakistani cohort. 61
30963551 2019
45
Impact of germinal center-associated nuclear protein polymorphisms on breast cancer risk and prognosis in a Japanese population. 61
30810967 2019
46
Electrophoretic mobility shift assays implicate XRCC2:rs3218550C>T as a potential low-penetrant susceptibility allele for sporadic breast cancer. 61
31370865 2019
47
A Multi-Center Study of BRCA1 and BRCA2 Germline Mutations in Mexican-Mestizo Breast Cancer Families Reveals Mutations Unreported in Latin American Population. 61
31454914 2019
48
Genotype data for single nucleotide polymorphism markers in sporadic breast cancer related genes in a Sri Lankan case-control cohort of postmenopausal women. 61
31324265 2019
49
Analysis of the pathogenic variants of BRCA1 and BRCA2 using next-generation sequencing in women with familial breast cancer: a case-control study. 61
31331294 2019
50
Novel BRCA2 pathogenic variant c.5219 T > G; p.(Leu1740Ter) in a consanguineous Senegalese family with hereditary breast cancer. 61
31060517 2019

Variations for Sporadic Breast Cancer

Expression for Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for Sporadic Breast Cancer

Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 TP53 RAD51 PTEN FANCD2 ESR2 ESR1
2
Show member pathways
13.8 TP53 PTEN PGR PARP1 FANCD2 ESR2
3
Show member pathways
13.22 XRCC1 TP53 RAD51 PARP1 PALB2 FANCD2
4
Show member pathways
12.98 TP53 PTEN FANCD2 CHEK2 BRCA1 BARD1
5
Show member pathways
12.95 TP53 RAD51 FANCD2 CHEK2 BRCA2 BRCA1
6 12.86 TP53 RAD51 PTEN ESR2 ESR1 ERBB2
7
Show member pathways
12.85 TP53 RAD51 PTEN ERBB2 BRCA2
8
Show member pathways
12.81 TP53 PTEN ESR1 BRCA1 BARD1
9
Show member pathways
12.79 TP53 PTEN PGR ESR2 ESR1 ERBB2
10
Show member pathways
12.66 TP53 PTEN FHIT ESR2 ESR1 ERBB2
11
Show member pathways
12.64 TP53 CHEK2 BRCA1 BARD1 ATM
12 12.57 TP53 PTEN MIR146A ERBB2 BRCA1 ATM
13 12.53 XRCC1 TP53 RAD51 FANCD2 CHEK2 BRCA2
14
Show member pathways
12.43 TP53 RAD51 PTEN FANCD2 CHEK2 BRCA1
15
Show member pathways
12.42 TP53 ERBB2 CHEK2 ATM
16
Show member pathways
12.39 TP53 CHEK2 BRCA1 BARD1 ATM
17 12.32 TP53 PTEN CHEK2 ATM
18
Show member pathways
12.32 RAD51 PALB2 BRCA2 BRCA1 BARD1 ATM
19
Show member pathways
12.27 TP53 PTEN CHEK2 BRCA1 ATM
20
Show member pathways
12.22 PGR ESR1 CHEK2 BRCA1
21
Show member pathways
12.19 RAD51 PALB2 BRCA2 BRCA1 BARD1 ATM
22 12.16 TP53 PTEN CHEK2 ATM
23
Show member pathways
12.01 XRCC1 TP53 RAD51 PARP1 FANCD2 ESR2
24 12 TP53 PTEN ERBB2 ATM
25 12 TP53 RAD51 PTEN ESR1 CHEK2 BRCA2
26 11.92 RAD51 PALB2 FANCD2 BRCA2 BRCA1
27
Show member pathways
11.91 TP53 RAD51 FANCD2 CHEK2 BRCA1 ATM
28 11.84 TP53 PTEN FHIT
29
Show member pathways
11.83 PGR ESR2 ESR1
30 11.78 TP53 ERBB2 BRCA1 ATM
31
Show member pathways
11.73 TP53 CHEK2 ATM
32 11.73 XRCC1 BRCA1 ATM
33 11.73 TP53 PTEN ERBB2 CHEK2 BRCA1 ATM
34 11.71 TP53 PTEN ERBB2
35 11.63 TP53 CHEK2 ATM
36 11.51 TP53 PTEN CHEK2 BRCA1 BARD1 ATM
37
Show member pathways
11.5 TP53 CHEK2 ATM
38
Show member pathways
11.48 TP53 RAD51 FANCD2 CHEK2 BRCA2 BRCA1
39 11.45 XRCC1 ESR1 CHEK2 BRCA2
40 11.44 TP53 FANCD2 CHEK2 BRCA1 BARD1 ATM
41 11.4 TP53 PTEN ESR1
42 11.33 PGR ESR2 ATM
43 11.32 TP53 BRCA1 ATM
44 11.2 TP53 RAD51 FANCD2 BRCA1 BARD1 ATM
45 11.17 PARP1 CHEK2 ATM
46 11.08 TP53 BRCA1 ATM
47 10.37 TP53 CHEK2
48 10.26 ESR2 ESR1

GO Terms for Sporadic Breast Cancer

Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.93 XRCC1 TTC4 TP53 RAD51 PTEN PGR
2 protein-containing complex GO:0032991 9.91 TP53 RAD51 PARP1 ESR1 BRCA2 BRCA1
3 site of double-strand break GO:0035861 9.65 TP53 RAD51 PARP1
4 chromosome, telomeric region GO:0000781 9.63 XRCC1 RAD51 PARP1 CHEK2 BRCA2 ATM
5 PML body GO:0016605 9.62 TP53 RAD51 PTEN CHEK2
6 nucleoplasm GO:0005654 9.55 XRCC1 TTC4 TP53 RAD51 PTEN PGR
7 condensed chromosome GO:0000793 9.54 RAD51 FANCD2 BRCA1
8 BRCA1-A complex GO:0070531 9.46 BRCA1 BARD1
9 lateral element GO:0000800 9.43 RAD51 BRCA2 BRCA1
10 BRCA1-BARD1 complex GO:0031436 9.4 BRCA1 BARD1

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.19 TP53 PGR PARP1 ESR2 ESR1 BRCA1
2 positive regulation of transcription, DNA-templated GO:0045893 10.12 TP53 ESR2 ESR1 CHEK2 BRCA2 BRCA1
3 cell cycle GO:0007049 10.09 TP53 FANCD2 CHEK2 BRCA2 BRCA1 ATM
4 apoptotic process GO:0006915 10.09 TP53 PTEN PARP1 FHIT CHEK2 BRCA1
5 positive regulation of gene expression GO:0010628 10.07 TP53 PTEN MIR146A ERBB2 BRCA1 ATM
6 positive regulation of apoptotic process GO:0043065 10.02 TP53 PTEN MIR146A BARD1 ATM
7 protein deubiquitination GO:0016579 10 TP53 PTEN ESR1 BRCA1 BARD1
8 regulation of apoptotic process GO:0042981 9.99 TP53 ESR1 BRCA1 ATM
9 heart development GO:0007507 9.98 TP53 PTEN ERBB2 ATM
10 transcription initiation from RNA polymerase II promoter GO:0006367 9.93 PTEN PGR ESR2 ESR1
11 DNA recombination GO:0006310 9.88 RAD51 PALB2 BRCA2 BRCA1
12 multicellular organism growth GO:0035264 9.85 TP53 PALB2 ATM
13 regulation of signal transduction by p53 class mediator GO:1901796 9.83 TP53 CHEK2 BRCA1 BARD1 ATM
14 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.82 TP53 CHEK2 ATM
15 double-strand break repair via nonhomologous end joining GO:0006303 9.81 XRCC1 BRCA1 BARD1 ATM
16 response to ionizing radiation GO:0010212 9.8 RAD51 BRCA1 ATM
17 somitogenesis GO:0001756 9.78 TP53 PALB2 ATM
18 double-strand break repair GO:0006302 9.77 TP53 PARP1 CHEK2 BRCA2 BRCA1
19 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.76 TP53 CHEK2 BRCA2
20 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.76 CHEK2 BRCA2 BRCA1 ATM
21 response to X-ray GO:0010165 9.71 TP53 RAD51 BRCA2
22 cellular response to gamma radiation GO:0071480 9.71 TP53 RAD51 CHEK2 ATM
23 replicative senescence GO:0090399 9.7 TP53 CHEK2 ATM
24 double-strand break repair via homologous recombination GO:0000724 9.7 XRCC1 RAD51 PARP1 PALB2 BRCA2 BRCA1
25 DNA repair GO:0006281 9.7 XRCC1 RAD51 PARP1 PALB2 FANCD2 EMSY
26 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.68 TP53 ESR1
27 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.68 TP53 ESR1
28 telomere maintenance via recombination GO:0000722 9.68 RAD51 BRCA2
29 protein K6-linked ubiquitination GO:0085020 9.67 BRCA1 BARD1
30 regulation of toll-like receptor signaling pathway GO:0034121 9.67 MIR146A ESR1
31 DNA double-strand break processing GO:0000729 9.67 BRCA1 BARD1 ATM
32 replication-born double-strand break repair via sister chromatid exchange GO:1990414 9.66 XRCC1 RAD51
33 chromosome organization involved in meiotic cell cycle GO:0070192 9.66 RAD51 ATM
34 DNA damage induced protein phosphorylation GO:0006975 9.65 CHEK2 ATM
35 intracellular steroid hormone receptor signaling pathway GO:0030518 9.65 PGR ESR2 ESR1
36 response to gamma radiation GO:0010332 9.65 TP53 PARP1 FANCD2 CHEK2 BRCA2
37 mitochondrial DNA repair GO:0043504 9.64 TP53 PARP1
38 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.62 TP53 CHEK2 BRCA2 BRCA1
39 chordate embryonic development GO:0043009 9.61 BRCA2 BRCA1
40 mitotic recombination-dependent replication fork processing GO:1990426 9.57 RAD51 BRCA2
41 positive regulation of single strand break repair GO:1903518 9.56 XRCC1 PARP1
42 cellular response to DNA damage stimulus GO:0006974 9.4 XRCC1 TP53 RAD51 PARP1 PALB2 FANCD2

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.47 XRCC1 TTC4 TP53 RAD51 PTEN PGR
2 DNA binding GO:0003677 10.02 TP53 RAD51 PGR PARP1 PALB2 ESR2
3 zinc ion binding GO:0008270 9.95 TP53 PGR PARP1 ESR2 ESR1 BRCA1
4 protein kinase binding GO:0019901 9.85 TP53 PTEN PARP1 ESR1 CHEK2
5 nuclear receptor activity GO:0004879 9.61 PGR ESR2 ESR1
6 enzyme binding GO:0019899 9.61 XRCC1 TP53 RAD51 PTEN PGR PARP1
7 identical protein binding GO:0042802 9.47 TP53 RAD51 PTEN PGR PARP1 FHIT
8 steroid binding GO:0005496 9.43 PGR ESR2 ESR1
9 estrogen receptor activity GO:0030284 9.4 ESR2 ESR1
10 estrogen response element binding GO:0034056 9.37 ESR2 ESR1
11 steroid hormone receptor activity GO:0003707 9.33 PGR ESR2 ESR1

Sources for Sporadic Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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