MCID: SPR009
MIFTS: 46

Sporadic Breast Cancer

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Sporadic Breast Cancer

MalaCards integrated aliases for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 12 15
Sporadic Breast Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8029
NCIt 50 C7566
UMLS 73 C1336076

Summaries for Sporadic Breast Cancer

MalaCards based summary : Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to cowden disease and mutagen sensitivity. An important gene associated with Sporadic Breast Cancer is BRCA1 (BRCA1, DNA Repair Associated), and among its related pathways/superpathways are ERK Signaling and Gene Expression. Affiliated tissues include breast and endothelial, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Sporadic Breast Cancer

Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
Sporadic Breast Cancer Breast Carcinoma in Situ

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 cowden disease 30.4 BRCA1 BRCA2 PTEN
2 mutagen sensitivity 29.8 BRCA1 BRCA2 TP53 XRCC1
3 xeroderma pigmentosum, variant type 29.3 ATM RAD51 TP53 XRCC1
4 breast disease 29.3 ERBB2 ESR1 ESR2 PGR TP53
5 bilateral breast cancer 27.0 ATM BRCA1 BRCA2 CHEK2 ERBB2 ESR1
6 ovarian cancer 24.9 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
7 breast cancer 24.3 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
8 hereditary site-specific ovarian cancer syndrome 11.0 BRCA1 BRCA2
9 breast reconstruction 11.0 BRCA1 BRCA2
10 endometrial clear cell adenocarcinoma 10.9 ESR1 TP53
11 vulvar syringoma 10.9 ESR1 PGR
12 lung leiomyoma 10.9 ESR1 PGR
13 vulvar benign neoplasm 10.8 ESR1 PGR
14 endometrium carcinoma in situ 10.8 PGR TP53
15 trigonitis 10.8 ESR1 PGR
16 vulvar leiomyoma 10.8 ESR1 PGR
17 predominantly cortical thymoma 10.8 ESR1 PGR
18 tetraploidy 10.8 BRCA2 TP53
19 nosophobia 10.7 BRCA1 BRCA2 PGR
20 cancerophobia 10.7 BRCA1 BRCA2 PGR
21 postmenopausal atrophic vaginitis 10.7 ESR1 ESR2
22 scirrhous adenocarcinoma 10.7 ERBB2 PGR
23 breast apocrine carcinoma 10.7 ERBB2 PGR
24 dysgerminoma of ovary 10.7 BRCA1 BRCA2 PGR
25 gallbladder squamous cell carcinoma 10.7 ERBB2 TP53
26 breast duct papilloma 10.7 PGR PTEN
27 gastric papillary adenocarcinoma 10.7 ERBB2 TP53
28 breast mucoepidermoid carcinoma 10.6 ERBB2 PGR
29 papillary serous adenocarcinoma 10.6 BRCA1 PGR TP53
30 comedo carcinoma 10.6 ERBB2 ESR1
31 vestibular gland benign neoplasm 10.6 ESR1 PGR TP53
32 bartholin's gland adenoma 10.6 ESR1 PGR TP53
33 tuberculous salpingitis 10.6 BRCA1 BRCA2 ERBB2
34 breast malignant phyllodes tumor 10.6 PGR TP53
35 olfactory groove meningioma 10.6 PGR TP53
36 breast metaplastic carcinoma 10.6 ERBB2 PGR
37 bartholin's gland benign neoplasm 10.6 ESR1 PGR TP53
38 intracystic papillary adenoma 10.6 ERBB2 PGR
39 cervical carcinosarcoma 10.6 ESR1 PGR TP53
40 progesterone resistance 10.6 ESR1 ESR2 PGR
41 adenosarcoma 10.6 ESR1 PGR TP53
42 myxosarcoma 10.6 ATM BRCA1 TP53
43 gender identity disorder 10.6 ESR1 ESR2 PGR
44 estrogen excess 10.6 ESR1 ESR2 PGR
45 endometriosis of ovary 10.6 ESR1 ESR2 PGR
46 progesterone-receptor negative breast cancer 10.6 ERBB2 PGR
47 cribriform carcinoma 10.5 ESR1 PGR
48 pelvic organ prolapse 10.5 ESR1 ESR2 PGR
49 sister chromatid exchange, frequency of 10.5 BRCA1 XRCC1
50 female reproductive system disease 10.5 ESR1 ESR2 PGR

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to Sporadic Breast Cancer

Symptoms & Phenotypes for Sporadic Breast Cancer

GenomeRNAi Phenotypes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.72 RAD51 BRCA1 BARD1
2 Decreased homologous recombination repair frequency GR00151-A-2 10.72 RAD51 BRCA1
3 Decreased homologous recombination repair frequency GR00236-A-1 10.72 RAD51 BRCA1 PGR BRCA2 BARD1
4 Decreased homologous recombination repair frequency GR00236-A-2 10.72 ATM RAD51 BRCA1 PGR BRCA2 BARD1
5 Decreased homologous recombination repair frequency GR00236-A-3 10.72 RAD51 BRCA1 BRCA2 BARD1
6 Decreased viability GR00221-A-2 10.28 BRCA1 CHEK2
7 Decreased viability GR00221-A-3 10.28 ERBB2 ATM BRCA1 CHEK2
8 Decreased viability GR00221-A-4 10.28 CHEK2 ERBB2 ATM
9 Decreased viability GR00301-A 10.28 BRCA1
10 Decreased viability GR00342-S-2 10.28 CHEK2
11 Decreased viability GR00402-S-2 10.28 ERBB2 ATM BRCA1 CHEK2
12 Decreased ionizing radiation sensitivity GR00232-A-1 10.03 TTC4 ATM ESR2 FANCD2 BRCA1 PGR
13 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 TP53 XRCC1 BRCA1 ATM FANCD2 BARD1
14 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 TP53 XRCC1 BRCA1 ATM FANCD2 BRCA2
15 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.81 XRCC1 FANCD2 TP53 BARD1 CHEK2 BRCA2
16 Increased cell death HMECs cells GR00103-A-0 9.73 TP53 TTC4 BRCA1 PGR PTEN RAD51
17 Decreased viability with cisplatin GR00101-A-4 9.62 BRCA1 BRCA2 BARD1 RAD51
18 Decreased viability after ionizing radiation GR00232-A-2 9.54 ATM BRCA1 BRCA2
19 Synthetic lethal with cisplatin GR00101-A-1 9.26 BARD1 RAD51 BRCA2 BRCA1

MGI Mouse Phenotypes related to Sporadic Breast Cancer:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 ERBB2 ESR2 ESR1 CHEK2 BRCA2 BARD1
2 behavior/neurological MP:0005386 10.32 ESR1 ERBB2 BRCA1 ATM BRCA2 FANCD2
3 homeostasis/metabolism MP:0005376 10.31 ERBB2 ESR2 CHEK2 ESR1 BRCA1 ATM
4 growth/size/body region MP:0005378 10.3 ERBB2 ESR1 BRCA1 ATM BARD1 BRCA2
5 embryo MP:0005380 10.29 ERBB2 ESR1 BRCA2 BARD1 BRCA1 ATM
6 endocrine/exocrine gland MP:0005379 10.28 ERBB2 ESR2 ESR1 CHEK2 ATM BRCA2
7 mortality/aging MP:0010768 10.28 ERBB2 ESR2 ESR1 CHEK2 ATM BRCA2
8 hematopoietic system MP:0005397 10.25 ESR2 CHEK2 ESR1 BRCA1 ATM BRCA2
9 immune system MP:0005387 10.22 ESR1 CHEK2 BRCA1 ATM BRCA2 FANCD2
10 neoplasm MP:0002006 10.17 ESR2 ESR1 CHEK2 ERBB2 BRCA2 BARD1
11 digestive/alimentary MP:0005381 10.16 ERBB2 ESR2 ESR1 BRCA1 BRCA2 FHIT
12 integument MP:0010771 10.16 ERBB2 ESR2 ESR1 ATM BRCA2 BRCA1
13 limbs/digits/tail MP:0005371 10.09 ERBB2 ESR2 ESR1 BRCA2 BRCA1 PTEN
14 adipose tissue MP:0005375 10.06 ESR1 BRCA1 ATM ESR2 TP53 PTEN
15 nervous system MP:0003631 10.03 ERBB2 ESR2 ESR1 CHEK2 ATM BARD1
16 muscle MP:0005369 9.91 ESR1 ERBB2 BRCA1 ESR2 PGR TP53
17 normal MP:0002873 9.85 ERBB2 ESR2 ESR1 BARD1 BRCA2 BRCA1
18 reproductive system MP:0005389 9.65 ERBB2 ESR2 ESR1 ATM BRCA2 BRCA1
19 skeleton MP:0005390 9.23 ESR1 ERBB2 BRCA2 BRCA1 PGR ESR2

Drugs & Therapeutics for Sporadic Breast Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Syndrome as Modifiable Risk Factor for Breast Cancer Unknown status NCT01172886
2 Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers Active, not recruiting NCT02087592 Not Applicable

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

Anatomical Context for Sporadic Breast Cancer

MalaCards organs/tissues related to Sporadic Breast Cancer:

41
Breast, Endothelial

Publications for Sporadic Breast Cancer

Articles related to Sporadic Breast Cancer:

(show top 50) (show all 290)
# Title Authors Year
1
Genetic determinants of sporadic breast cancer in Sri Lankan women. ( 29433565 )
2018
2
Association analysis of interleukin-18 gene promoter region polymorphisms and susceptibility to sporadic breast cancer in Chinese Han women. ( 29926984 )
2018
3
Distinct role of endothelial nitric oxide synthase gene polymorphisms from menopausal status in the patients with sporadic breast cancer in Taiwan. ( 29102546 )
2018
4
Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features. ( 29453630 )
2018
5
Genetic Variants Associated with Clinicopathological Profiles in Sporadic Breast Cancer in Sri Lankan Women. ( 29963112 )
2018
6
CHEK2 Germ Line Mutations are Lacking among Familial and Sporadic Breast Cancer Patients in Rwanda ( 29479983 )
2018
7
EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer. ( 29661238 )
2018
8
Simultaneous ATM/BRCA1/RAD51 expression variations associated with prognostic factors in Iranian sporadic breast cancer patients. ( 28058614 )
2017
9
Patient-derived Interstitial Fluids and Predisposition to Aggressive Sporadic Breast Cancer through Collagen Remodeling and Inactivation of p53. ( 28630214 )
2017
10
Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. ( 28190851 )
2017
11
Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers. ( 27837030 )
2017
12
Can MTHFR C677T and A1298C Polymorphisms Alter the Risk and Severity of Sporadic Breast Cancer in Brazilian Women? ( 28330681 )
2017
13
Variants of estrogen receptor alpha and beta genes modify the severity of sporadic breast cancer. ( 28109853 )
2017
14
Computational Investigation of Homologous Recombination DNA Repair Deficiency in Sporadic Breast Cancer. ( 29146938 )
2017
15
TGFbeta and miRNA regulation in familial and sporadic breast cancer. ( 28881597 )
2017
16
Cost-effectiveness Analysis of Contralateral Prophylactic Mastectomy Compared to Unilateral Mastectomy with Routine Surveillance for Unilateral, Sporadic Breast Cancer. ( 29039025 )
2017
17
Contralateral risk reducing mastectomy in patients with sporadic breast cancer. Benefits and hazards. ( 27189832 )
2016
18
A Genome-Wide Association Study to Identify Potential Germline Copy Number Variants for Sporadic Breast Cancer Susceptibility. ( 27668787 )
2016
19
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility. ( 26650628 )
2016
20
Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer. ( 26723934 )
2016
21
Twenty-one-gene recurrence score assay in BRCA-associated versus sporadic breast cancers: Differences based on germline mutation status. ( 26859126 )
2016
22
A study on promoter methylation of PTEN in sporadic breast cancer patients from North India. ( 26754093 )
2016
23
RECQL4 helicase has oncogenic potential in sporadic breast cancers. ( 26690729 )
2016
24
Association between genetic variants of EGF-containing fibulin-like extracellular matrix protein1 gene and sporadic breast cancer in a Chinese Han population. ( 27048115 )
2016
25
Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients. ( 26205471 )
2016
26
Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients. ( 27413552 )
2016
27
Differential Cytotoxicity, Cellular Uptake, Apoptosis and Inhibition of BRCA1 Expression of BRCA1-Defective and Sporadic Breast Cancer Cells Induced by an Anticancer Ruthenium(II)-Arene Compound, RAPTA-EA1. ( 27039925 )
2016
28
Promoter methylation and expression changes of BRCA1 in cancerous tissues of patients with sporadic breast cancer. ( 25789047 )
2015
29
Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China. ( 26535628 )
2015
30
A novel BRCA2 in frame deletion in a Tunisian woman with early onset sporadic breast cancer. ( 26320393 )
2015
31
Development and validation of molecular methodologies to assess PALB2 expression in sporadic breast cancer. ( 26526077 )
2015
32
Assessing Heavy Metal and PCB Exposure from Tap Water by Measuring Levels in Plasma from Sporadic Breast Cancer Patients, a Pilot Study. ( 26690196 )
2015
33
Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer. ( 26430163 )
2015
34
Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study. ( 26476291 )
2015
35
Decreased Expression of BRCA2 Accelerates Sporadic Breast Cancer Progression. ( 27065665 )
2015
36
First description of a sporadic breast cancer in a woman with BRCA1 germline mutation. ( 26426992 )
2015
37
Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women. ( 26598080 )
2015
38
DNA repair genes XRCC1 and ERCC1 polymorphisms and the risk of sporadic breast cancer in Han women in the Gansu Province of China. ( 25961110 )
2015
39
Association of BRCA1 promoter methylation with sporadic breast cancers: Evidence from 40 studies. ( 26643130 )
2015
40
Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer. ( 26456802 )
2015
41
ATM gene mutations in sporadic breast cancer patients from Brazil. ( 25625042 )
2015
42
The CHEK2 1100delC allelic variant is not present in familial and sporadic breast cancer cases from Moroccan population. ( 25674498 )
2015
43
Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. ( 24556691 )
2014
44
Association of TNF-I+, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of sporadic breast cancer in northeast Chinese Han women. ( 25010932 )
2014
45
A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival. ( 25067956 )
2014
46
The promoter methylation status and mRNA expression levels of CTCF and SIRT6 in sporadic breast cancer. ( 24842653 )
2014
47
Association of +405C>G and +936C>T polymorphisms of the vascular endothelial growth factor gene with sporadic breast cancer in North Indians. ( 24528036 )
2014
48
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis. ( 24464625 )
2014
49
Association of promoter methylation of ERI+ and ERI^ with sporadic breast cancer--a study from North India. ( 24833090 )
2014
50
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts. ( 25425972 )
2014

Variations for Sporadic Breast Cancer

Expression for Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for Sporadic Breast Cancer

Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 ATM BRCA1 CHEK2 ERBB2 ESR1 ESR2
2
Show member pathways
13.79 ATM BARD1 BRCA1 CHEK2 ERBB2 ESR1
3
Show member pathways
13.4 ATM BARD1 BRCA1 BRCA2 CHEK2 RAD51
4
Show member pathways
13.19 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
5
Show member pathways
12.96 ATM BARD1 BRCA1 CHEK2 FANCD2 PTEN
6
Show member pathways
12.9 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
7
Show member pathways
12.84 BRCA2 ERBB2 PTEN RAD51 TP53
8 12.82 BRCA2 ERBB2 ESR1 ESR2 PTEN RAD51
9
Show member pathways
12.8 BARD1 BRCA1 ESR1 PTEN TP53
10
Show member pathways
12.78 BRCA1 BRCA2 ERBB2 ESR1 ESR2 PGR
11
Show member pathways
12.76 ATM BRCA1 BRCA2 ERBB2 ESR1 ESR2
12
Show member pathways
12.63 ATM BARD1 BRCA1 CHEK2 TP53
13 12.53 ATM BRCA1 BRCA2 CHEK2 FANCD2 RAD51
14 12.52 ATM BRCA1 ERBB2 PTEN TP53
15
Show member pathways
12.5 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
16
Show member pathways
12.47 ATM BRCA1 BRCA2 RAD51
17
Show member pathways
12.46 ERBB2 ESR1 ESR2 PTEN
18
Show member pathways
12.41 ATM CHEK2 ERBB2 TP53
19
Show member pathways
12.41 ATM BRCA1 CHEK2 FANCD2 PTEN RAD51
20
Show member pathways
12.37 ATM BARD1 BRCA1 CHEK2 TP53
21
Show member pathways
12.3 ATM BARD1 BRCA1 BRCA2 RAD51
22
Show member pathways
12.25 ATM BRCA1 CHEK2 PTEN TP53
23
Show member pathways
12.22 BRCA1 CHEK2 ESR1 PGR
24 12.16 ATM CHEK2 PTEN TP53
25
Show member pathways
12.15 ATM BARD1 BRCA1 BRCA2 RAD51
26 11.99 ATM ERBB2 PTEN TP53
27
Show member pathways
11.92 ERBB2 ESR1 PGR
28 11.9 BRCA1 BRCA2 FANCD2 RAD51
29
Show member pathways
11.89 ATM BRCA1 CHEK2 FANCD2 RAD51 TP53
30 11.84 FHIT PTEN TP53
31
Show member pathways
11.83 ESR1 ESR2 PGR
32 11.75 ATM BRCA1 ERBB2 TP53
33 11.72 ATM BRCA1 XRCC1
34
Show member pathways
11.72 ATM CHEK2 TP53
35 11.7 ATM BRCA1 CHEK2 ERBB2 PTEN TP53
36 11.67 ERBB2 PTEN TP53
37 11.62 ATM CHEK2 TP53
38 11.51 ATM BARD1 BRCA1 CHEK2 PTEN TP53
39
Show member pathways
11.48 ATM CHEK2 TP53
40
Show member pathways
11.48 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
41 11.46 ATM BARD1 BRCA1 BRCA2 CHEK2 ESR1
42 11.44 ATM BARD1 BRCA1 CHEK2 FANCD2 TP53
43 11.42 BRCA2 CHEK2 ESR1 XRCC1
44 11.39 ESR1 PTEN TP53
45 11.32 ATM BRCA1 TP53
46 11.31 ATM ESR2 PGR
47 11.2 ATM BARD1 BRCA1 FANCD2 RAD51 TP53
48 11.06 ATM BRCA1 TP53
49 10.36 CHEK2 TP53
50 10.25 ESR1 ESR2

GO Terms for Sporadic Breast Cancer

Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.88 BRCA1 BRCA2 ESR1 RAD51 TP53
2 nucleus GO:0005634 9.86 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
3 nuclear chromatin GO:0000790 9.76 ESR1 RAD51 TP53 XRCC1
4 nuclear chromosome, telomeric region GO:0000784 9.71 ATM BRCA2 RAD51 XRCC1
5 PML body GO:0016605 9.56 CHEK2 PTEN RAD51 TP53
6 condensed chromosome GO:0000793 9.54 BRCA1 FANCD2 RAD51
7 nucleoplasm GO:0005654 9.47 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
8 BRCA1-A complex GO:0070531 9.43 BARD1 BRCA1
9 lateral element GO:0000800 9.33 BRCA1 BRCA2 RAD51
10 BRCA1-BARD1 complex GO:0031436 9.32 BARD1 BRCA1
11 cytoplasm GO:0005737 10.31 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.97 ATM BRCA1 CHEK2 ESR1 TP53
2 protein deubiquitination GO:0016579 9.96 BARD1 BRCA1 ESR1 PTEN TP53
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.84 ESR1 ESR2 PTEN
4 DNA recombination GO:0006310 9.84 BRCA1 BRCA2 RAD51
5 regulation of signal transduction by p53 class mediator GO:1901796 9.83 ATM BARD1 BRCA1 CHEK2 TP53
6 double-strand break repair GO:0006302 9.8 BRCA1 BRCA2 CHEK2
7 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.8 ATM CHEK2 TP53
8 double-strand break repair via nonhomologous end joining GO:0006303 9.8 ATM BARD1 BRCA1 XRCC1
9 steroid hormone mediated signaling pathway GO:0043401 9.79 ESR1 ESR2 PGR
10 response to ionizing radiation GO:0010212 9.79 ATM BRCA1 RAD51
11 double-strand break repair via homologous recombination GO:0000724 9.77 ATM BRCA1 BRCA2 RAD51 XRCC1
12 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.76 ATM BRCA1 BRCA2 CHEK2
13 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.72 BRCA2 CHEK2 TP53
14 cellular response to gamma radiation GO:0071480 9.71 ATM CHEK2 TP53
15 response to gamma radiation GO:0010332 9.71 BRCA2 CHEK2 FANCD2 TP53
16 DNA double-strand break processing GO:0000729 9.69 ATM BARD1 BRCA1
17 determination of adult lifespan GO:0008340 9.66 ATM TP53
18 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.65 ESR1 TP53
19 telomere maintenance via recombination GO:0000722 9.65 BRCA2 RAD51
20 chromosome organization involved in meiotic cell cycle GO:0070192 9.65 ATM RAD51
21 replicative senescence GO:0090399 9.65 ATM CHEK2 TP53
22 DNA synthesis involved in DNA repair GO:0000731 9.65 ATM BARD1 BRCA1 BRCA2 RAD51
23 protein K6-linked ubiquitination GO:0085020 9.64 BARD1 BRCA1
24 DNA damage induced protein phosphorylation GO:0006975 9.63 ATM CHEK2
25 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.62 BRCA1 BRCA2 CHEK2 TP53
26 DNA repair GO:0006281 9.61 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
27 chordate embryonic development GO:0043009 9.59 BRCA1 BRCA2
28 strand displacement GO:0000732 9.55 ATM BARD1 BRCA1 BRCA2 RAD51
29 mitotic recombination-dependent replication fork processing GO:1990426 9.52 BRCA2 RAD51
30 cellular response to DNA damage stimulus GO:0006974 9.32 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
31 transcription, DNA-templated GO:0006351 10.3 BRCA1 CHEK2 EMSY ERBB2 ESR1 ESR2
32 regulation of transcription, DNA-templated GO:0006355 10.27 BRCA1 BRCA2 CHEK2 EMSY ERBB2 ESR1
33 apoptotic process GO:0006915 10.08 ATM BRCA1 CHEK2 FHIT PTEN TP53
34 cell cycle GO:0007049 10.08 ATM BRCA1 BRCA2 CHEK2 FANCD2 TP53
35 positive regulation of transcription, DNA-templated GO:0045893 10.06 BRCA1 BRCA2 CHEK2 ESR1 ESR2 TP53

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.92 CHEK2 ESR1 PTEN RHOBTB2 TP53
2 nucleotide binding GO:0000166 9.88 ATM CHEK2 ERBB2 FHIT RAD51
3 ubiquitin protein ligase binding GO:0031625 9.85 BRCA1 CHEK2 FHIT TP53
4 lipid binding GO:0008289 9.84 ESR1 ESR2 PGR PTEN
5 damaged DNA binding GO:0003684 9.69 BRCA1 TP53 XRCC1
6 steroid hormone receptor activity GO:0003707 9.67 ESR1 ESR2 PGR
7 nuclear receptor activity GO:0004879 9.61 ESR1 ESR2 PGR
8 core promoter sequence-specific DNA binding GO:0001046 9.58 ESR1 ESR2 TP53
9 enzyme binding GO:0019899 9.5 BRCA1 ESR1 ESR2 PGR PTEN TP53
10 estrogen receptor activity GO:0030284 9.46 ESR1 ESR2
11 steroid binding GO:0005496 9.43 ESR1 ESR2 PGR
12 estrogen response element binding GO:0034056 9.37 ESR1 ESR2
13 identical protein binding GO:0042802 9.32 BRCA2 CHEK2 ERBB2 ESR1 ESR2 FHIT
14 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 9.16 ESR1 ESR2
15 protein binding GO:0005515 10.25 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY

Sources for Sporadic Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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