MCID: SPR009
MIFTS: 42

Sporadic Breast Cancer

Categories: Cancer diseases, Genetic diseases, Immune diseases, Rare diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Sporadic Breast Cancer

MalaCards integrated aliases for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 11 14
Sporadic Breast Carcinoma 71

Classifications:



External Ids:

Disease Ontology 11 DOID:8029
NCIt 49 C7566
UMLS 71 C1336076

Summaries for Sporadic Breast Cancer

Disease Ontology: 11 A breast carcinoma that occurs in people who do not have a family history of that cancer or an inherited change in their DNA that would increase their risk for that cancer.

MalaCards based summary: Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to hereditary breast cancer and breast-ovarian cancer, familial 1. An important gene associated with Sporadic Breast Cancer is EMSY (EMSY Transcriptional Repressor, BRCA2 Interacting), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. Affiliated tissues include breast, prostate and endothelial, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Sporadic Breast Cancer

Diseases in the Breast Cancer family:

Inflammatory Breast Carcinoma Sporadic Breast Cancer
Breast Carcinoma in Situ Hereditary Breast Cancer

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 hereditary breast cancer 31.3 PALB2 CHEK2 BRCA2 BRCA1
2 breast-ovarian cancer, familial 1 30.6 PALB2 BRCA2 BRCA1
3 ovarian cancer 1 30.6 PALB2 BRCA2 BRCA1
4 telangiectasis 30.6 TP53 H2AC18 CHEK2 ATM
5 familial ovarian cancer 30.5 TP53 CHEK2 ATM
6 female breast cancer 30.4 TP53 PGR ESR1 ERBB2 BRCA2 BRCA1
7 fanconi anemia, complementation group d2 30.4 RAD51 H2AC18 BRCA2 BRCA1 ATM
8 breast-ovarian cancer, familial 2 30.4 BRCA2 BRCA1
9 papilloma 30.3 TP53 PTEN ESR1 ERBB2
10 ataxia-telangiectasia 30.3 TP53 RAD51 CHEK2 BRCA2 BRCA1 ATM
11 in situ carcinoma 30.2 TP53 PTEN PGR ESR1 ERBB2 BRCA2
12 breast fibroadenoma 30.2 TP53 PGR ESR1 ERBB2 BRCA2 BRCA1
13 peutz-jeghers syndrome 30.1 TP53 PTEN BRCA2
14 breast ductal carcinoma 30.1 TP53 PTEN PGR ESR1 ERBB2 BRCA2
15 inherited cancer-predisposing syndrome 30.0 TP53 PTEN PALB2 CHEK2 BRCA2 BRCA1
16 bap1 tumor predisposition syndrome 30.0 TP53 PTEN PALB2 CHEK2 BRCA2 BRCA1
17 ductal carcinoma in situ 30.0 TP53 PTEN PGR ESR1 ERBB2 BRCA2
18 deficiency anemia 29.9 TP53 RAD51 PALB2 H2AC18 BRCA2 BRCA1
19 breast disease 29.9 TP53 PGR MIR146A MIR10B H2AC18 FHIT
20 nijmegen breakage syndrome 29.7 TP53 RAD51 H2AC18 CHEK2 BRCA2 BRCA1
21 xeroderma pigmentosum, variant type 29.7 TP53 RAD51 H2AC18 CHEK2 BRCA2 BRCA1
22 breast cancer 29.7 TP53 RAD51 PTEN PGR PALB2 MIR146A
23 breast lobular carcinoma 29.6 TP53 PTEN PGR PALB2 ESR1 ERBB2
24 fanconi anemia, complementation group a 29.5 TP53 RAD51 PTEN PALB2 H2AC18 EMSY
25 bladder cancer 29.5 TP53 PTEN MIR10B H2AC18 FHIT ESR1
26 colonic benign neoplasm 29.5 TP53 PTEN PALB2 H2AC18 ESR1 ERBB2
27 cowden syndrome 1 29.5 TP53 PTEN PALB2 CHEK2 BRCA2 BRCA1
28 endometrial cancer 29.4 TP53 RAD51 PTEN PGR H2AC18 FHIT
29 hereditary breast ovarian cancer syndrome 29.4 TP53 RAD51 PTEN PGR PALB2 H2AC18
30 bilateral breast cancer 29.2 TP53 RAD51 PTEN PGR PALB2 FHIT
31 ovarian cancer 28.9 TP53 RAD51 PTEN PGR PALB2 MIR146A
32 cowden syndrome 28.9 TP53 RAD51 PTEN PGR PALB2 ESR1
33 prostate cancer 28.6 TP53 RAD51 PTEN PGR MIR146A MIR10B
34 colorectal cancer 28.4 TP53 RAD51 PTEN PGR PALB2 MIR146A
35 hereditary site-specific ovarian cancer syndrome 10.4 BRCA2 BRCA1
36 ovary transitional cell carcinoma 10.4 BRCA2 BRCA1
37 uterine corpus adenosarcoma 10.4 PGR ESR1
38 cancerophobia 10.4 BRCA2 BRCA1
39 nosophobia 10.4 BRCA2 BRCA1
40 adult cystic nephroma 10.4 PGR ESR1
41 scirrhous adenocarcinoma 10.4 PGR ERBB2
42 vagina leiomyosarcoma 10.4 PGR ESR1
43 vulvar benign neoplasm 10.4 PGR ESR1
44 adenosquamous breast carcinoma 10.4 TP53 PGR
45 lipid-rich breast carcinoma 10.4 PGR ERBB2
46 her2-receptor negative breast cancer 10.4 PGR ERBB2
47 tetraploidy 10.4 TP53 BRCA2
48 diffuse peritoneal leiomyomatosis 10.4 PGR ESR1
49 peritoneal benign neoplasm 10.4 PGR ESR1
50 ovarian cyst 10.4 PGR ESR1 BRCA1

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to Sporadic Breast Cancer

Symptoms & Phenotypes for Sporadic Breast Cancer

GenomeRNAi Phenotypes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

25 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.32 BARD1 BRCA1 RAD51
2 Decreased homologous recombination repair frequency GR00151-A-2 10.32 BRCA1 RAD51
3 Decreased homologous recombination repair frequency GR00236-A-1 10.32 BARD1 BRCA1 BRCA2 PALB2 RAD51
4 Decreased homologous recombination repair frequency GR00236-A-2 10.32 BARD1 BRCA1 BRCA2 PALB2 RAD51
5 Decreased homologous recombination repair frequency GR00236-A-3 10.32 BARD1 BRCA1 BRCA2 PALB2 RAD51
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.01 BARD1 BRCA1 BRCA2 PALB2 PTEN
7 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.01 ATM BRCA1 BRCA2 PALB2 PTEN TP53
8 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 10.01 ATM BARD1 BRCA1 BRCA2 CHEK2 TP53
9 Synthetic lethal with cisplatin GR00101-A-1 9.73 BARD1 BRCA1 BRCA2 RAD51
10 Decreased viability with cisplatin GR00101-A-4 9.71 BARD1 BRCA1 BRCA2 RAD51
11 Decreased viability after ionizing radiation GR00232-A-2 9.43 ATM BRCA1 BRCA2
12 Decreased viability in pancreas lineage GR00235-A 9.33 CHEK2 PGR TP53
13 Increased homologous recombination repair frequency GR00236-A-1 9.26 PGR
14 Increased homologous recombination repair frequency GR00236-A-2 9.26 PGR
15 Increased cell death in HCT116 cells GR00103-A-0 9.07 RAD51

MGI Mouse Phenotypes related to Sporadic Breast Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10.27 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
2 homeostasis/metabolism MP:0005376 10.25 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
3 endocrine/exocrine gland MP:0005379 10.11 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
4 embryo MP:0005380 10.1 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1
5 cellular MP:0005384 10.07 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
6 limbs/digits/tail MP:0005371 10.03 BRCA1 BRCA2 ERBB2 ESR1 PALB2 PGR
7 reproductive system MP:0005389 9.9 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
8 mortality/aging MP:0010768 9.86 ATM BARD1 BRCA1 BRCA2 CHEK2 ERBB2
9 integument MP:0010771 9.36 ATM BRCA1 BRCA2 ERBB2 ESR1 FHIT

Drugs & Therapeutics for Sporadic Breast Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Decision Making Tool for Contralateral Prophylactic Mastectomy Recruiting NCT02918474

Search NIH Clinical Center for Sporadic Breast Cancer

Genetic Tests for Sporadic Breast Cancer

Anatomical Context for Sporadic Breast Cancer

Organs/tissues related to Sporadic Breast Cancer:

MalaCards : Breast, Prostate, Endothelial, Lymph Node, Thyroid, Brain, Lung

Publications for Sporadic Breast Cancer

Articles related to Sporadic Breast Cancer:

(show top 50) (show all 884)
# Title Authors PMID Year
1
Comparison of Outcomes Between BRCA Pathogenic Variant Carriers Undergoing Breast-Conserving Surgery Versus Mastectomy. 62
35585432 2022
2
Dietary phytochemicals/nutrients as promising protector of breast cancer development: a comprehensive analysis. 62
35661126 2022
3
Genome-wide investigations on regulatory functions of RECQ1 helicase. 62
35231585 2022
4
A pilot study on DNA hypermethylation status in promoter region of P16 gene in patients with sporadic breast cancer. 62
35855710 2022
5
High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing. 62
35768433 2022
6
Does breast-conserving surgery with radiotherapy in BRCA-mutation carriers significantly increase ipsilateral breast tumor recurrence? A systematic review and meta-analysis. 62
35212965 2022
7
Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1). 62
35190584 2022
8
Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic Breast Cancer in Mexican Women. 62
35200585 2022
9
MicroRNAs miR-142-5p, miR-150-5p, miR-320a-3p, and miR-4433b-5p in Serum and Tissue: Potential Biomarkers in Sporadic Breast Cancer. 62
35846122 2022
10
Germline Mutation Analysis in Sporadic Breast Cancer Cases With Clinical Correlations. 62
35356428 2022
11
CBCRisk model to determine the risk of contralateral breast cancer in sporadic breast cancer. 62
34764058 2021
12
OncotypeDX© Recurrence Score in BRCA mutation carriers: a systematic review and meta-analysis. 62
34284256 2021
13
A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients. 62
34285278 2021
14
Pterostilbene Changes Epigenetic Marks at Enhancer Regions of Oncogenes in Breast Cancer Cells. 62
34439480 2021
15
Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy. 62
33247475 2021
16
Four novel BRCA variants found in Chinese hereditary breast cancer patients by next-generation sequencing. 62
33476590 2021
17
Combined breast conservation therapy versus mastectomy for BRCA mutation carriers - A systematic review and meta-analysis. 62
33582622 2021
18
Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study. 62
33417321 2021
19
The Clinical and Pathological Profile of BRCA1 Gene Methylated Breast Cancer Women: A Meta-Analysis. 62
33808555 2021
20
Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells. 62
33468559 2021
21
Inflammation Mediates the Development of Aggressive Breast Cancer Following Radiotherapy. 62
33402361 2021
22
Frequency of high-risk hormone receptor-positive breast cancer patients was much higher in Japanese breast cancer patients with germline BRCA1/2 mutations than in sporadic breast cancer patients. 62
33378795 2021
23
[Systematic and quality-assured early diagnosis of sporadic breast cancer : Update on screening effects and scientific studies]. 62
33492420 2021
24
Discovery of novel DNA methylation biomarkers for non-invasive sporadic breast cancer detection in the Latino population. 62
33145876 2021
25
Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications. 62
33271295 2021
26
CBCRisk model to determine the risk of contralateral breast cancer in sporadic breast cancer. 62
33358405 2020
27
Characteristics of Breast Ducts in Normal-Risk and High-risk Women and Their Relationship to Ductal Cytologic Atypia. 62
32753377 2020
28
Preneoplasia of the Breast and Molecular Landscape. 62
32972772 2020
29
Predictive and prognostic value of LSP1 rs3817198 in sporadic breast cancer in northeastern population of Iran. 62
32738313 2020
30
Genomic Diversity in Sporadic Breast Cancer in a Latin American Population. 62
33126731 2020
31
DNA Methylation and Breast Cancer Risk: An Epigenome-Wide Study of Normal Breast Tissue and Blood. 62
33113958 2020
32
Frequency of the TP53 R337H variant in sporadic breast cancer and its impact on genomic instability. 62
33024147 2020
33
Comparison of clinical features and oncologic outcomes between familial non-hereditary and hereditary breast cancer in Korean female patients. 62
31924417 2020
34
Promoter Hypermethylation and Expression Changes of BRCA1 Gene in a Cohort of Sporadic Breast Cancer Cases among Pakistani Population. 62
32856871 2020
35
Clinicopathological characteristics of BRCA-associated breast cancer in Asian patients. 62
32397691 2020
36
Study of DOK4 gene expression and promoter methylation in sporadic breast cancer. 62
32386480 2020
37
Breast Conserving Surgery for BRCA Mutation Carriers-A Systematic Review. 62
32144082 2020
38
Evaluation of non-coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity. 62
32346478 2020
39
EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases. 62
32580276 2020
40
Discussions about contralateral prophylactic mastectomy among surgical oncology providers and women with sporadic breast cancer: a content analysis. 62
30561744 2020
41
What surgical oncology providers and women with sporadic breast cancer should not forget in the decision-making about contralateral prophylactic mastectomy! 62
30698813 2020
42
The Relationship between KIT Copy Number Variation, Protein Expression, and Angiogenesis in Sporadic Breast Cancer. 62
32821750 2020
43
BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer. 62
32235500 2020
44
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies. 62
31650727 2020
45
MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia. 62
32192442 2020
46
Prognosis of BRCA1/2-negative breast cancer patients with HBOC risk factors compared with sporadic breast cancer patients without HBOC risk factors. 62
31926487 2020
47
miRNA expression profiling of hereditary breast tumors from BRCA1- and BRCA2-germline mutation carriers in Brazil. 62
32087690 2020
48
How Computational Experiments Can Improve Our Understanding of the Genetic Architecture of Common Human Diseases. 62
32027528 2020
49
A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population. 62
32142098 2020
50
Interplay between BRCA1 and GADD45A and Its Potential for Nucleotide Excision Repair in Breast Cancer Pathogenesis. 62
32013256 2020

Variations for Sporadic Breast Cancer

Expression for Sporadic Breast Cancer

Search GEO for disease gene expression data for Sporadic Breast Cancer.

Pathways for Sporadic Breast Cancer

Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 TP53 RAD51 PTEN PGR H2AC18 ESR1
2
Show member pathways
13.82 TP53 RAP2A RAD51 PTEN ESR1 ERBB2
3
Show member pathways
13.79 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1
4
Show member pathways
13.51 ATM BARD1 BRCA1 BRCA2 CHEK2 H2AC18
5
Show member pathways
13.19 TP53 RAD51 PALB2 H2AC18 CHEK2 BRCA2
6
Show member pathways
12.95 TP53 PTEN CHEK2 BRCA1 BARD1 ATM
7
Show member pathways
12.91 TP53 RAD51 CHEK2 BRCA2 BRCA1 BARD1
8
Show member pathways
12.83 TP53 PTEN H2AC18 ESR1 BRCA1 BARD1
9
Show member pathways
12.76 RAD51 PALB2 BRCA2 BRCA1 BARD1 ATM
10
Show member pathways
12.75 TP53 CHEK2 BRCA1 BARD1 ATM
11
Show member pathways
12.71 RAD51 H2AC18 BRCA2 BRCA1 ATM
12
Show member pathways
12.7 TP53 RAD51 PTEN FHIT ERBB2 BRCA2
13 12.69 TP53 PTEN BRCA1 BARD1 ATM
14
Show member pathways
12.63 RAD51 PALB2 BRCA2 BRCA1 ATM
15
Show member pathways
12.57 TP53 RAD51 ESR1 CHEK2 BRCA2 BRCA1
16 12.51 TP53 RAD51 CHEK2 BRCA2 BRCA1 ATM
17
Show member pathways
12.44 TP53 PTEN ESR1 ERBB2
18
Show member pathways
12.42 TP53 ERBB2 CHEK2 ATM
19
Show member pathways
12.38 TP53 CHEK2 BRCA1 BARD1 ATM
20
Show member pathways
12.36 BRCA1 CHEK2 ESR1 PGR
21
Show member pathways
12.33 RAD51 PALB2 BRCA2 BRCA1 BARD1 ATM
22
Show member pathways
12.24 TP53 RAD51 PTEN PGR ESR1 ERBB2
23
Show member pathways
12.2 TP53 PTEN CHEK2 BRCA1 ATM
24
Show member pathways
12.11 ATM BRCA1 CHEK2 RAD51 TP53
25 11.94 TP53 PTEN ERBB2 ATM
26 11.87 TP53 PTEN FHIT
27
Show member pathways
11.87 TP53 RAD51 CHEK2 BRCA2 BRCA1 ATM
28
Show member pathways
11.81 ATM BRCA1 CHEK2 RAD51 TP53
29 11.77 TP53 PTEN PAGR1 ESR1
30
Show member pathways
11.75 TP53 CHEK2 ATM
31 11.74 TP53 PTEN ERBB2
32
Show member pathways
11.72 TP53 RAD51 CHEK2 BRCA2 BRCA1 BARD1
33 11.71 TP53 PTEN ESR1
34 11.68 PGR ESR1 BRCA1
35 11.67 TP53 PTEN ERBB2 BRCA1 ATM
36 11.55 TP53 CHEK2 ATM
37
Show member pathways
11.5 TP53 CHEK2 ATM
38 11.5 TP53 CHEK2 BRCA1 BARD1 ATM
39 11.47 TP53 RAD51 PALB2 CHEK2 BRCA2 BRCA1
40 11.46 TP53 RAD51 PTEN ESR1 CHEK2 BRCA2
41 11.43 TP53 PTEN ESR1
42 11.4 H2AC18 BRCA1 BARD1
43 11.38 BRCA2 CHEK2 ESR1
44 11.38 ATM BARD1 BRCA1 CHEK2 PTEN TP53
45 11.33 PGR ESR1 ERBB2
46 11.33 TP53 PTEN CHEK2 ATM
47 11.32 TP53 BRCA1 ATM
48 11.23 TP53 RAD51 BRCA1 BARD1 ATM
49 11.07 TP53 BRCA1 ATM
50 10.87 PGR ESR1 ERBB2

GO Terms for Sporadic Breast Cancer

Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 9.86 TP53 RAD51 PTEN CHEK2
2 BRCA1-C complex GO:0070533 9.71 BRCA1 BARD1
3 BRCA1-B complex GO:0070532 9.67 BRCA1 BARD1
4 lateral element GO:0000800 9.63 BRCA1 BRCA2 RAD51
5 BRCA1-BARD1 complex GO:0031436 9.62 BRCA1 BARD1
6 DNA repair complex GO:1990391 9.56 PALB2 BRCA2 BRCA1 ATM
7 nuclear ubiquitin ligase complex GO:0000152 9.23 RAD51 BRCA2 BRCA1 BARD1

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.32 TP53 PGR MIR146A ERBB2 BRCA1 ATM
2 regulation of cell cycle GO:0051726 10.25 TP53 PTEN BRCA1 BARD1 ATM
3 double-strand break repair via homologous recombination GO:0000724 10.16 RAD51 PALB2 BRCA2 BRCA1 ATM
4 protein autoubiquitination GO:0051865 10.15 RAD51 BRCA2 BRCA1 BARD1
5 somitogenesis GO:0001756 10.09 TP53 PALB2 ATM
6 double-strand break repair GO:0006302 10.07 TP53 CHEK2 BRCA2 BRCA1 ATM
7 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 10.05 BRCA2 CHEK2 TP53
8 cellular response to gamma radiation GO:0071480 10.03 TP53 RAD51 CHEK2 ATM
9 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 10.02 ATM BRCA1 BRCA2 CHEK2
10 response to X-ray GO:0010165 10.01 BRCA2 RAD51 TP53
11 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 10 TP53 CHEK2 ATM
12 replicative senescence GO:0090399 9.99 TP53 CHEK2 ATM
13 signal transduction in response to DNA damage GO:0006975 9.98 CHEK2 ATM
14 signal transduction in response to DNA damage GO:0042770 9.98 CHEK2 ATM
15 response to gamma radiation GO:0010332 9.97 TP53 CHEK2 BRCA2
16 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.97 TP53 CHEK2 BRCA2
17 DNA recombination GO:0006310 9.95 BRCA1 BRCA2 PAGR1 PALB2 RAD51
18 DNA strand resection involved in replication fork processing GO:0110025 9.93 BRCA1 BARD1
19 histone H2A monoubiquitination GO:0035518 9.92 RAD51 BRCA2 BRCA1 BARD1
20 positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 9.89 TP53 ESR1
21 mitotic recombination-dependent replication fork processing GO:1990426 9.86 RAD51 BRCA2
22 regulation of DNA damage checkpoint GO:2000001 9.86 BARD1 BRCA1 BRCA2 RAD51
23 cellular response to ionizing radiation GO:0071479 9.85 TP53 RAD51 BRCA2 BRCA1 BARD1
24 DNA repair GO:0006281 9.8 ATM BARD1 BRCA1 BRCA2 CHEK2 EMSY
25 chromosome organization involved in meiotic cell cycle GO:0070192 9.79 RAD51 ATM
26 chordate embryonic development GO:0043009 9.78 BRCA1 BRCA2
27 cellular response to DNA damage stimulus GO:0006974 9.53 TP53 RAD51 PALB2 PAGR1 EMSY CHEK2

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.73 TP53 RAD51 PTEN PGR ESR1 BRCA1
2 identical protein binding GO:0042802 9.68 TP53 RAD51 PTEN PGR FHIT ESR1

Sources for Sporadic Breast Cancer

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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